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glycine cleavage system protein GcvH [Nakamurella flavida]

Protein Classification

glycine cleavage system protein H( domain architecture ID 10785558)

glycine cleavage system protein H plays a role in the degradation of glycine by shuttling the methylamine group of glycine from P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase).

EC:  1.4.1.27
Gene Ontology:  GO:0019464|GO:0009249|GO:0005960
PubMed:  20375021|18941301

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 2-130 2.15e-70

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440275  Cd Length: 128  Bit Score: 206.90  E-value: 2.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:COG0509     3 IPDDLKYTEDHEWVRVEGDG----TATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1994461056  82 ARNEVLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQVAGE 130
Cdd:COG0509    79 EVNEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLEE 127
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 2-130 2.15e-70

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 206.90  E-value: 2.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:COG0509     3 IPDDLKYTEDHEWVRVEGDG----TATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1994461056  82 ARNEVLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQVAGE 130
Cdd:COG0509    79 EVNEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLEE 127
PRK01202 PRK01202
glycine cleavage system protein GcvH;
2-130 1.20e-66

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 197.30  E-value: 1.20e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYSSDHEWVRTTGDeadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:PRK01202    4 IPADLKYTKSHEWVRVEGD-----TATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1994461056  82 ARNEVLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQVAGE 130
Cdd:PRK01202   79 EVNEALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEALIEE 127
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 8-107 3.40e-47

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 147.29  E-value: 3.40e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   8 YSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVARNEVL 87
Cdd:cd06848     1 YTKDHEWVKVEGDG----IATVGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEAL 76

                          90       100
                  ....*....|....*....|
gi 1994461056  88 DSTPELVNSDPYGDGWMIEV 107
Cdd:cd06848    77 LDNPELINSDPYGEGWLVKI 96
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 2-124 3.57e-46

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 145.75  E-value: 3.57e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:TIGR00527   2 GPQDLRYSSEHEWVRVEGDK----TATVGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1994461056  82 ARNEVLDSTPELVNSDPYGDGWMIEVQLTDP-SALDDLLDAAGY 124
Cdd:TIGR00527  78 EVNTALEDSPELVNEDPYGDGWLIKVKLSDGeSEVEGLMSAEQY 121
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 6-126 3.13e-45

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 143.24  E-value: 3.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   6 LRYSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVARNE 85
Cdd:pfam01597   1 LYYTKEHEWVKVEGDG----TATVGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNE 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1994461056  86 VLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQ 126
Cdd:pfam01597  77 KLEDNPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEK 117
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 2-130 2.15e-70

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 206.90  E-value: 2.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:COG0509     3 IPDDLKYTEDHEWVRVEGDG----TATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1994461056  82 ARNEVLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQVAGE 130
Cdd:COG0509    79 EVNEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLEE 127
PRK01202 PRK01202
glycine cleavage system protein GcvH;
2-130 1.20e-66

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 197.30  E-value: 1.20e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYSSDHEWVRTTGDeadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:PRK01202    4 IPADLKYTKSHEWVRVEGD-----TATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1994461056  82 ARNEVLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQVAGE 130
Cdd:PRK01202   79 EVNEALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEALIEE 127
PRK13380 PRK13380
glycine cleavage system protein H; Provisional
 2-126 8.23e-49

glycine cleavage system protein H; Provisional


Pssm-ID: 237370  Cd Length: 144  Bit Score: 152.85  E-value: 8.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYS-SDHEWVRTTGDeaDTVTVriGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTV 80
Cdd:PRK13380    9 IPSELRYTiKNHEWLRLEGD--GTVTV--GITDYAQTMAGDVVFVRLKELGKKVEKGKPVATLESGKWAGPVPAPLTGEV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1994461056  81 VARNEVLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQ 126
Cdd:PRK13380   85 VEVNEALEDSPELVNEDPYGEGWFFRFKPANPEELKQLLDGDAADR 130
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 8-107 3.40e-47

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 147.29  E-value: 3.40e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   8 YSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVARNEVL 87
Cdd:cd06848     1 YTKDHEWVKVEGDG----IATVGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEAL 76

                          90       100
                  ....*....|....*....|
gi 1994461056  88 DSTPELVNSDPYGDGWMIEV 107
Cdd:cd06848    77 LDNPELINSDPYGEGWLVKI 96
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 2-124 3.57e-46

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 145.75  E-value: 3.57e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   2 IPEDLRYSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:TIGR00527   2 GPQDLRYSSEHEWVRVEGDK----TATVGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1994461056  82 ARNEVLDSTPELVNSDPYGDGWMIEVQLTDP-SALDDLLDAAGY 124
Cdd:TIGR00527  78 EVNTALEDSPELVNEDPYGDGWLIKVKLSDGeSEVEGLMSAEQY 121
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 6-126 3.13e-45

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 143.24  E-value: 3.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   6 LRYSSDHEWVRTTGDEadtvTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVARNE 85
Cdd:pfam01597   1 LYYTKEHEWVKVEGDG----TATVGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNE 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1994461056  86 VLDSTPELVNSDPYGDGWMIEVQLTDPSALDDLLDAAGYAQ 126
Cdd:pfam01597  77 KLEDNPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEK 117
PRK00624 PRK00624
glycine cleavage system protein H; Provisional
 8-111 3.29e-16

glycine cleavage system protein H; Provisional


Pssm-ID: 167014  Cd Length: 114  Bit Score: 69.09  E-value: 3.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056   8 YSSDHEWVrttgDEADTVTVRIGITDYAQNSLGDIVFVQVPEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVARNEVL 87
Cdd:PRK00624    4 YSDYHVWI----EPIHSRIVRLGLTSKMQENLGNILHIDLPSVGSFCKEGEVLVILESSKSAIEVLSPVSGEVIEVNTAL 79

                          90       100
                  ....*....|....*....|....
gi 1994461056  88 DSTPELVNSDPYGDGWMIEVQLTD 111
Cdd:PRK00624   80 EDDIQPINNAPESEGWFVVVQLDE 103
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 29-107 4.63e-09

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 49.36  E-value: 4.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994461056  29 IGITDYAQnSLGDIVFVQV-PEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVARNEVLDSTPElvnsdpyGDGWMIEV 107
Cdd:cd06663     2 ILIPDLAQ-HLGDGTVVKWlKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVE-------GDTPLVKI 73
PRK11856 PRK11856
branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed
 40-82 2.00e-04

branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed


Pssm-ID: 237001 [Multi-domain]  Cd Length: 411  Bit Score: 39.39  E-value: 2.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1994461056  40 GDIV--FVQvpePGTTVEPGESIGEVESTKSVSDLFSPVSGTVVA 82
Cdd:PRK11856   17 GEIVewLVK---VGDTVKEGQPLAEVETDKATVEIPSPVAGTVAK 58
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 40-81 5.96e-04

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 36.23  E-value: 5.96e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1994461056  40 GDIVFVQVpEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:cd06849    15 GTIVEWLV-KEGDSVEEGDVLAEVETDKATVEVEAPAAGVLA 55
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 39-80 1.10e-03

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 37.49  E-value: 1.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1994461056  39 LGDIVFVQVPE----PGTTVEPGESIGEVESTKSVSDLFSPVSGTV 80
Cdd:PRK11855   10 IGEVVEVEVIEwlvkEGDTVEEDQPLVTVETDKATMEIPSPAAGVV 55
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 39-81 1.84e-03

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 36.72  E-value: 1.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1994461056  39 LGDIVFVQVPE----PGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:PRK11855  127 IGEITEVEVIEwlvkVGDTVEEDQSLITVETDKATMEIPSPVAGVVK 173
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 29-92 4.85e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 35.62  E-value: 4.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1994461056  29 IGITDYAQNSLGDIVFVQVpEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVARN-EVLDSTPE 92
Cdd:TIGR01348   3 IKVPDIGDNEEGEVIEVLV-KPGDKVEAGQSLITLESDKASMEVPSSAAGIIKEIKvKVGDTLPV 66
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 49-81 6.42e-03

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 33.50  E-value: 6.42e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1994461056  49 EPGTTVEPGESIGEVESTKSVSDLFSPVSGTVV 81
Cdd:COG0508    25 KEGDTVKEGDPLAEVETDKATMEVPAPAAGVLL 57
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 34-82 8.17e-03

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 34.10  E-value: 8.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1994461056  34 YAQNSLGDIVFVQVpepGTTVEPGESIGEVESTKSVSDLFSPVSGTVVA 82
Cdd:COG0511    72 YRAPSPGAKPFVKV---GDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVE 117
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 40-82 8.70e-03

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 32.77  E-value: 8.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1994461056  40 GDIVFVQVpEPGTTVEPGESIGEVESTKSVSDLFSPVSGTVVA 82
Cdd:cd06850     8 GTVVKVLV-KEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKE 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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