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Conserved domains on  [gi|1994708509|ref|WP_205390617|]
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carboxymuconolactone decarboxylase family protein [Mycolicibacterium hippocampi]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 10001777)

carboxymuconolactone decarboxylase (CMD) family protein similar to alkyl hydroperoxide reductase AhpD, which is required for the reduction of the AhpC active site cysteine residues to regenerate its enzyme activity; carboxymuconolactone d

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4000771

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 40-121 5.81e-32

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


:

Pssm-ID: 440364  Cd Length: 114  Bit Score: 108.88  E-value: 5.81e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994708509  40 GVESVFGRLWGRDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEVIYHSSGYAGFPAANSACKVAREV 119
Cdd:COG0599    28 AFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGFPAALNALRAALEV 107


                  ..
gi 1994708509 120 LQ 121
Cdd:COG0599   108 LE 109
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 40-121 5.81e-32

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 108.88  E-value: 5.81e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994708509  40 GVESVFGRLWGRDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEVIYHSSGYAGFPAANSACKVAREV 119
Cdd:COG0599    28 AFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGFPAALNALRAALEV 107


                  ..
gi 1994708509 120 LQ 121
Cdd:COG0599   108 LE 109
decarb_PcaC TIGR02425
4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone ...
 32-120 8.69e-27

4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other]


Pssm-ID: 131478  Cd Length: 123  Bit Score: 95.97  E-value: 8.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994708509  32 FGDELLEIGVESVFGRLWGRDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEVIYHSSGYAGFPAANS 111
Cdd:TIGR02425  31 FDQPFQELITEYAWGTVWTRPGLTKRERSLVTIALLAALGRDEELAMHVRATANTGVTEDDIKEVLLHVAIYAGVPAANH 110


                  ....*....
gi 1994708509 112 ACKVAREVL 120
Cdd:TIGR02425 111 AFALAKEAL 119
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 45-118 1.22e-20

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 79.28  E-value: 1.22e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1994708509  45 FGRLWGrDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEVIYHSSGYAGFPAANSACKVARE 118
Cdd:pfam02627  12 FGLLWD-GGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALAAAEE 84
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 40-121 5.81e-32

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 108.88  E-value: 5.81e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994708509  40 GVESVFGRLWGRDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEVIYHSSGYAGFPAANSACKVAREV 119
Cdd:COG0599    28 AFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGFPAALNALRAALEV 107


                  ..
gi 1994708509 120 LQ 121
Cdd:COG0599   108 LE 109
decarb_PcaC TIGR02425
4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone ...
 32-120 8.69e-27

4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other]


Pssm-ID: 131478  Cd Length: 123  Bit Score: 95.97  E-value: 8.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994708509  32 FGDELLEIGVESVFGRLWGRDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEVIYHSSGYAGFPAANS 111
Cdd:TIGR02425  31 FDQPFQELITEYAWGTVWTRPGLTKRERSLVTIALLAALGRDEELAMHVRATANTGVTEDDIKEVLLHVAIYAGVPAANH 110


                  ....*....
gi 1994708509 112 ACKVAREVL 120
Cdd:TIGR02425 111 AFALAKEAL 119
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 45-118 1.22e-20

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 79.28  E-value: 1.22e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1994708509  45 FGRLWGrDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEVIYHSSGYAGFPAANSACKVARE 118
Cdd:pfam02627  12 FGLLWD-GGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALAAAEE 84
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 45-96 1.61e-03

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 36.01  E-value: 1.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1994708509  45 FGRLWGRDGLSRRDRSLVTLGILIALRATDELQFHVQIARNNGLTEDEIAEV 96
Cdd:COG2128    13 SGALMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDAL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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