|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
115-480 |
3.59e-92 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 285.68 E-value: 3.59e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 115 MLVEVSALRNMTEETVRFARHDPDDGQQFFLAALYRPSANLIVQVGQPPPPLYSLAQRSQVVLVLGMILALVLALIGSFI 194
Cdd:COG5002 20 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 195 AAYQVTTPLTRISETARRVADGKLTGKIQVESRAAEFQDLAESLNRASDTFREK-IEELERMTRLQSEFIGNVSHEVRNP 273
Cdd:COG5002 100 ALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERdITELERLEQMRREFVANVSHELRTP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 274 IFSISGYLEAL-GTPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEE 352
Cdd:COG5002 180 LTSIRGYLELLlDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEE 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 353 KGLDLEADVSR--FFVHADRSRVRQVLTNLIENGIAYTG-GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYR 429
Cdd:COG5002 260 KGIELELDLPEdpLLVLGDPDRLEQVLTNLLDNAIKYTPeGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYR 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1995275685 430 VDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELPYEPE 480
Cdd:COG5002 340 VDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
246-480 |
6.19e-79 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 245.97 E-value: 6.19e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 246 REKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALG-TPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYK 324
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLdEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 325 EDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADV--SRFFVHADRSRVRQVLTNLIENGIAYTG-GGSVRCRVQRRL 401
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLppELPLVYADPELLEQVLANLLDNAIKYSPpGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1995275685 402 DKVRVEVVDTGQGIDEDHLDRIFERFYRVDpdRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELPYEPE 480
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
153-476 |
2.65e-76 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 242.51 E-value: 2.65e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 153 ANLIVQVGQPPPPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKIQVESRAAEFQ 232
Cdd:COG0642 4 LLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 233 DLAESLNRASDTFREKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTpGLDDEQRKmYSEKALTNLNRLQNLF 312
Cdd:COG0642 84 LLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLE-ELDEEQRE-YLETILRSADRLLRLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 313 NDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSR--FFVHADRSRVRQVLTNLIENGIAYTG- 389
Cdd:COG0642 162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDdlPTVRGDPDRLRQVLLNLLSNAIKYTPe 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 390 GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGT 469
Cdd:COG0642 242 GGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*..
gi 1995275685 470 RFWFELP 476
Cdd:COG0642 320 TFTVTLP 326
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
249-473 |
2.43e-61 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 203.59 E-value: 2.43e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 249 IEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEAL-GTPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYKEDL 327
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLaDGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 328 INRSVFDLKDLVDEVAEMLRPKAEEKG----LDLEADVSrffVHADRSRVRQVLTNLIENGIAYTG-GGSVRCRVQRRLD 402
Cdd:TIGR02966 184 LEDEPVDMPALLDHLRDEAEALSQGKNhqitFEIDGGVD---VLGDEDELRSAFSNLVSNAIKYTPeGGTITVRWRRDGG 260
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1995275685 403 KVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWF 473
Cdd:TIGR02966 261 GAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSF 331
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
175-482 |
5.46e-52 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 181.70 E-value: 5.46e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 175 VVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKIQVESRAaEFQDLAESLNRASDTFREKIEELER 254
Cdd:COG5000 9 LLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDD-EIGELARAFNRMTDQLKEQREELEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 --------------------------------------------------------------------------------
Cdd:COG5000 88 rrryletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgr 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 255 ---------------------MTRLQS--------EFIGNVSHEVRNPIFSISGYLEAL-----GTPGLDDEQRKMYSEK 300
Cdd:COG5000 168 rtllvrasplrddgyvivfddITELLRaerlaawgELARRIAHEIKNPLTPIQLSAERLrrklaDKLEEDREDLERALDT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 301 ALTNLNRLQNLFNDLIDIARLEykedLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADV--SRFFVHADRSRVRQVLT 378
Cdd:COG5000 248 IIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLdpDLPEVLADRDQLEQVLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 379 NLIENGI-AYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGE 457
Cdd:COG5000 324 NLLKNAIeAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGG 397
|
410 420
....*....|....*....|....*
gi 1995275685 458 DIHVESTKGRGTRFWFELPYEPEPE 482
Cdd:COG5000 398 TIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
51-476 |
8.36e-51 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 179.12 E-value: 8.36e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 51 TAMQETLHDQADriavqaEQEPDPVRRGRIVDNLTELQDLHVSLVTPDTTYRPS----PQTAPPFPAD--MLVEVSALRN 124
Cdd:TIGR01386 48 EQVRRFLRDPAD------LDEDIKRLQEKIDDLLVGHSDLALSILNPDGRLLFEraqgAALVPAVAANdaLLELDQADAK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 125 MTEETVRFARHDPDDGQQfflaalyrPSANLIVQVGQPPPPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLT 204
Cdd:TIGR01386 122 MTHYRSILRSVAALPGGK--------GRKPVQITVALDINAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 205 RISETARRVADGKLTGKIQVESRAAEFQDLAESLNRAsdtfrekIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLE-A 283
Cdd:TIGR01386 194 RLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAM-------LGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQvA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 284 LGTPGLDDEQRKMYsEKALTNLNRLQNLFNDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSR 363
Cdd:TIGR01386 267 LSQPRTGEEYREVL-ESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGEG 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 364 FfVHADRSRVRQVLTNLIENGIAYTG-GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTG 442
Cdd:TIGR01386 346 L-VRGDPQMFRRAISNLLSNALRHTPdGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTG 424
|
410 420 430
....*....|....*....|....*....|....
gi 1995275685 443 LGLSIVKQILQAHGEDIHVESTKGRgTRFWFELP 476
Cdd:TIGR01386 425 LGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
244-476 |
7.63e-49 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 171.51 E-value: 7.63e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 244 TFREKIEEL----ERMTrLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEqRKMYSEKALTNLNRLQNLFNDLIDIA 319
Cdd:COG5807 129 TKRKEAEDKllrsEKLS-VAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSE-REEYFNIIISEIDRINTIITELLVLS 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 320 rleyKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVS--RFFVHADRSRVRQVLTNLIENGI-AYTGGGSVRCR 396
Cdd:COG5807 207 ----KPKKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLAddEPVINGDKNQLKQVFINLIKNAIeAMETGGNITIK 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 397 VQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:COG5807 283 TYVEGDFVVISVKDEGIGIPEEVLEKIGEPFF------TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
143-476 |
2.92e-48 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 169.98 E-value: 2.92e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 143 FFLAALYRPSANLIVQVGQPPPPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKI 222
Cdd:COG4191 18 LALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 223 QVESRAAEFQDLaESLNRASDTFREKIEELERM-------TRLQS--EFIGNVSHEVRNPIFSISGYLEALG---TPGLD 290
Cdd:COG4191 98 LAALDAEENAEL-EELERDITELERAEEELRELqeqlvqsEKLAAlgELAAGIAHEINNPLAAILGNAELLRrrlEDEPD 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 291 DEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYKEdlinRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSR--FFVHA 368
Cdd:COG4191 177 PEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALELLRPRLKARGIEVELDLPPdlPPVLG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 369 DRSRVRQVLTNLIENGI-AYTGG--GSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFY--RvdpdrsRESGGTGL 443
Cdd:COG4191 253 DPGQLEQVLLNLLINAIdAMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttK------PVGKGTGL 326
|
330 340 350
....*....|....*....|....*....|...
gi 1995275685 444 GLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:COG4191 327 GLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
4-480 |
3.28e-48 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 173.43 E-value: 3.28e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 4 VRSIRDALLPRRASTQTWMVLTFALFVGTAVVGVGLYVMLVLRGEMRTAMQETLHDQADRIAVQAEQEPDPVRRGRIVDN 83
Cdd:COG4251 27 VLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLAL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 84 LTELQDLHVSLVTPDTTYRPSPQTAPPFPADMLVEVSALRNMTEETVRFARHDPDDGQQFFLAALYRPSANLIVQVGQPP 163
Cdd:COG4251 107 LLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 164 PPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKIQVESRAAEFQDLAESLNRASD 243
Cdd:COG4251 187 VLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEE 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 244 TFREKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGT---PGLDDEQRKmYSEKALTNLNRLQNLFNDLIDIAR 320
Cdd:COG4251 267 ELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEdygDKLDEEGRE-YLERIRDAAERMQALIDDLLAYSR 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 321 LEYKEdlINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFfVHADRSRVRQVLTNLIENGIAYTGGGS---VRCRV 397
Cdd:COG4251 346 VGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT-VRGDPTLLRQVFQNLISNAIKYSRPGEpprIEIGA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 398 QRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSREsgGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELPY 477
Cdd:COG4251 423 EREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
...
gi 1995275685 478 EPE 480
Cdd:COG4251 501 APA 503
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
246-477 |
3.59e-43 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 157.72 E-value: 3.59e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 246 REKIEELERMtRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYKe 325
Cdd:COG5806 189 RKELQRAEKL-EVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPE- 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 326 dliNRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSR-FFVHADRSRVRQVLTNLIENGI-AYTGGGSVRCRVQRRLDK 403
Cdd:COG5806 267 ---KLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPgLYIEGDRQKLQQCLINIIKNGIeAMPNGGTLTIDVSIDKNK 343
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995275685 404 VRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELPY 477
Cdd:COG5806 344 VIISIKDTGVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
246-483 |
4.54e-43 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 158.98 E-value: 4.54e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 246 REKIEELERMTRLQ--SEFIGNVSHEVRNPIFSISGYLEALgtPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIAR--- 320
Cdd:COG5809 255 KKLEELLRKSEKLSvvGELAAGIAHEIRNPLTSLKGFIQLL--KDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKpqa 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 321 LEYKEdlinrsvFDLKDLVDEVAEMLRPKAEEKG----LDLEADVSrfFVHADRSRVRQVLTNLIENGI-AYTGGGSVRC 395
Cdd:COG5809 333 IKYEP-------KDLNTLIEEVIPLLQPQALLKNvqieLELEDDIP--DILGDENQLKQVFINLLKNAIeAMPEGGNITI 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 396 RVQRRL-DKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFE 474
Cdd:COG5809 404 ETKAEDdDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSIT 477
|
....*....
gi 1995275685 475 LPYEPEPEA 483
Cdd:COG5809 478 LPIKLSEQV 486
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
229-483 |
1.22e-42 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 155.00 E-value: 1.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 229 AEFQDLAEslnrasdtfREKIE-ELERMTRLQS--EFIGNVSHEVRNPIFSISGYLEALGTpGLDDEQRKMYSEKALTNL 305
Cdd:COG3852 111 LVLRDITE---------RKRLErELRRAEKLAAvgELAAGLAHEIRNPLTGIRGAAQLLER-ELPDDELREYTQLIIEEA 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 306 NRLQNLFNDLIDIARleykEDLINRSVFDLKDLVDEVAEMLRPKAEEK-GLDLEADVSRFFVHADRSRVRQVLTNLIENG 384
Cdd:COG3852 181 DRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLELLRAEAPKNiRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNA 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 385 I-AYTGGG--SVRCRVQRRL--------DKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQ 453
Cdd:COG3852 257 AeAMPEGGtiTIRTRVERQVtlgglrprLYVRIEVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVE 330
|
250 260 270
....*....|....*....|....*....|
gi 1995275685 454 AHGEDIHVESTKGRGTRFWFELPYEPEPEA 483
Cdd:COG3852 331 QHGGTIEVESEPGKGTTFRIYLPLEQAEEE 360
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
368-478 |
1.18e-39 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 138.94 E-value: 1.18e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 368 ADRSRVRQVLTNLIENGIAYTG-GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDpDRSRESGGTGLGLS 446
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 1995275685 447 IVKQILQAHGEDIHVESTKGRGTRFWFELPYE 478
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
176-476 |
2.50e-39 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 148.45 E-value: 2.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 176 VLVLGMILALVLALIGSFIAaYQVTTPLTRISETARRVADGKltgKIQV-ESRAAEFQDLAeslnRASDTFREKIE---E 251
Cdd:PRK11100 184 ILWAGALLLGIALLIGAGVV-WWLNRSIRRLTRYADAVTEGK---PVPLpKLGSSELRELA----QALESMRVKLEgkaY 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 252 LERmtrlqseFIGNVSHEVRNPIFSISGYLEALgTPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYKEDLINRS 331
Cdd:PRK11100 256 VEQ-------YVQTLTHELKSPLAAIRGAAELL-QEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLE 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 332 VFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSRVRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVRVEVVD 410
Cdd:PRK11100 328 PVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSAEVDGEQVALSVED 407
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1995275685 411 TGQGIDEDHLDRIFERFY---RvdPDRSRESggTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:PRK11100 408 QGPGIPDYALPRIFERFYslpR--PANGRKS--TGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
248-476 |
6.10e-38 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 143.61 E-value: 6.10e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 248 KIEELERMTRlqsEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRkmysEKAL----TNLNRLQNLFNDLIDIARLEY 323
Cdd:PRK11006 196 QMHQLEGARR---NFFANVSHELRTPLTVLQGYLEMMQDQPLEGALR----EKALhtmrEQTQRMEGLVKQLLTLSKIEA 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 324 KEDLinrsvfDLKDLVDeVAEMLRpkaeekGLDLEA------------DVSRFF-VHADRSRVRQVLTNLIENGIAYT-G 389
Cdd:PRK11006 269 APTI------DLNEKVD-VPMMLR------VLEREAqtlsqgkhtitfEVDNSLkVFGNEDQLRSAISNLVYNAVNHTpE 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 390 GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGT 469
Cdd:PRK11006 336 GTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGT 415
|
....*..
gi 1995275685 470 RFWFELP 476
Cdd:PRK11006 416 RFSFVLP 422
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
373-476 |
1.42e-37 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 133.39 E-value: 1.42e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYTGGGSVRCRVQRRLD-----KVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSI 447
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1995275685 448 VKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
373-475 |
6.05e-37 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 131.19 E-value: 6.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPdrSRESGGTGLGLSIVKQI 451
Cdd:cd00075 1 LEQVLSNLLDNALKYSpPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1995275685 452 LQAHGEDIHVESTKGRGTRFWFEL 475
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
175-484 |
2.76e-36 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 143.07 E-value: 2.76e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 175 VVLVLGMILALVLAligsFIAAYQVTTPLT-------RISETAR--RVaDGKLTG-----KIQVESRA---AEFQD-LAE 236
Cdd:PRK11107 182 LMLLLGIGLALLFA----FRLMRDVTGPIRnmvntvdRIRRGQLdsRV-EGNMLGeldmlKNGINAMAmslSAYHEeMQQ 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 237 SLNRASDTFREKIEELE--------------RMTRLQSEFIGNVSHEVRNPIFSISGYL-EALGTPgLDDEQRKMYS--E 299
Cdd:PRK11107 257 NIDQATSDLRETLEQMEiqnveldlakkraqEAARIKSEFLANMSHELRTPLNGVIGFTrQTLKTP-LTPTQRDYLQtiE 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 300 KALTNLnrlQNLFNDLIDIARLEyKEDLINRSV-FDLKDLVDEVAEMLRPKAEEKGLDL----EADVSRFFVhADRSRVR 374
Cdd:PRK11107 336 RSANNL---LAIINDILDFSKLE-AGKLVLENIpFSLRETLDEVVTLLAHSAHEKGLELtlniDPDVPDNVI-GDPLRLQ 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 375 QVLTNLIENGIAYTGGGSVRCRVQRRL---DKV--RVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVK 449
Cdd:PRK11107 411 QIITNLVGNAIKFTESGNIDILVELRAlsnTKVqlEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQ 490
|
330 340 350
....*....|....*....|....*....|....*
gi 1995275685 450 QILQAHGEDIHVESTKGRGTRFWFELPYEPEPEAV 484
Cdd:PRK11107 491 KLVNEMGGDISFHSQPNRGSTFWFHLPLDLNPNPI 525
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
250-476 |
3.10e-36 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 142.77 E-value: 3.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 250 EELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMYSE---KALTnlnrLQNLFNDLIDIARLEY-KE 325
Cdd:PRK11091 274 DALEKASRDKTTFISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTihvSAIT----LGNIFNDIIDMDKMERrKL 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 326 DLINRSVfDLKDLVDEVAEMLRPKAEEKGL--DLEADVS-RFFVHADRSRVRQVLTNLIENGIAYTGGGSVRCRVQRRL- 401
Cdd:PRK11091 350 QLDNQPI-DFTDFLADLENLSGLQAEQKGLrfDLEPLLPlPHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEg 428
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1995275685 402 DKVRVEVVDTGQGIDEDHLDRIFERFYRV-DPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:PRK11091 429 DMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
181-476 |
9.02e-36 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 138.75 E-value: 9.02e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 181 MILALVLALIGSFI---AAYQVTTPLTRISETARRVADGKLTGKIQVESRAAEFQDLAESLNRasdtFREKIEELerMTR 257
Cdd:PRK09835 188 IMTASVISLLIVFIvllAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNH----MIERIEDV--FTR 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 258 lQSEFIGNVSHEVRNPIFSISGYLE-ALGTPGLDDE-QRKMYSEkaLTNLNRLQNLFNDLIDIARLEYKEDLINRSVFDL 335
Cdd:PRK09835 262 -QSNFSADIAHEIRTPITNLITQTEiALSQSRSQKElEDVLYSN--LEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDL 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 336 KDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSRVRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVRVEVVDTGQG 414
Cdd:PRK09835 339 ADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTpAGEAITVRCQEVDHQVQLVVENPGTP 418
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995275685 415 IDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAHGEDIHVEStKGRGTRFWFELP 476
Cdd:PRK09835 419 IAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
181-482 |
9.31e-36 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 138.23 E-value: 9.31e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 181 MILAL--VLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKIQVESRAaEFQDLAESLNRASDTFrEKIEELERmtrl 258
Cdd:PRK10549 168 LIVALstLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRD-ELGRLAQDFNQLASTL-EKNEQMRR---- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 259 qsEFIGNVSHEVRNPIFSISGYLEALgtpglDDEQRKMYSEkALTNLN----RLQNLFNDL-----IDIARLEYKEDLIn 329
Cdd:PRK10549 242 --DFMADISHELRTPLAVLRGELEAI-----QDGVRKFTPE-SVASLQaevgTLTKLVDDLhqlslSDEGALAYRKTPV- 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 330 rsvfDLKDLVDEVAEMLRPKAEEKGLDLEADV---SRFFvhADRSRVRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVR 405
Cdd:PRK10549 313 ----DLVPLLEVAGGAFRERFASRGLTLQLSLpdsATVF--GDPDRLMQLFNNLLENSLRYTdSGGSLHISAEQRDKTLR 386
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1995275685 406 VEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELPYEPEPE 482
Cdd:PRK10549 387 LTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
182-481 |
3.27e-35 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 139.78 E-value: 3.27e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 182 ILALV-LALIGSFIAAYQVTTPL----TRISETARRVADGKLtgkiqVESRAAEFQDLAESLNRASDTFREKIEELE--- 253
Cdd:PRK15347 303 LLILVlLTSVLFLLLRRYLAKPLwrfvDIINKTGPAALEPRL-----PENRLDELGSIAKAYNQLLDTLNEQYDTLEnkv 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 254 ---------------RMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMySEKALTNLNRLQNLFNDLIDI 318
Cdd:PRK15347 378 aertqalaeakqraeQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDL-ADTARQCTLSLLAIINNLLDF 456
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 319 ARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFF---VHADRSRVRQVLTNLIENGIAYTGGGSVRC 395
Cdd:PRK15347 457 SRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVplyLHLDSLRLRQILVNLLGNAVKFTETGGIRL 536
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 396 RVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDpdrsRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFEL 475
Cdd:PRK15347 537 RVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD----THSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612
|
330
....*....|
gi 1995275685 476 PYE----PEP 481
Cdd:PRK15347 613 PLNeyapPEP 622
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
231-480 |
1.06e-34 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 137.02 E-value: 1.06e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 231 FQDLAESlnrasDTFREKIEELERMTRLqSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKmYSEKALTNLNRLQN 310
Cdd:PRK11360 368 FSDLTER-----KRLQRRVARQERLAAL-GELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQE-YLSVVLREVDRLNK 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 311 LFNDLIDIARleykedlINRSVF---DLKDLVDEVAEMLRPKAEEKGLDLEADVSRFF--VHADRSRVRQVLTNLIENGI 385
Cdd:PRK11360 441 VIDQLLEFSR-------PRESQWqpvSLNALVEEVLQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNILINAV 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 386 -AYTGGGSVRCRVQRRLD-KVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVES 463
Cdd:PRK11360 514 qAISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVES 587
|
250
....*....|....*..
gi 1995275685 464 TKGRGTRFWFELPYEPE 480
Cdd:PRK11360 588 EPGVGTTFTLYLPINPQ 604
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
238-476 |
9.57e-34 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 130.84 E-value: 9.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 238 LNRASDTFREKIEELERMTRLqsefignVSHEVRNPIFSISGYLEALgtpglDDEQRKMYSEKALTNLNRLQN------- 310
Cdd:PRK09303 137 LRQENETLLEQLKFKDRVLAM-------LAHDLRTPLTAASLALETL-----ELGQIDEDTELKPALIEQLQDqarrqle 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 311 ----LFNDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFF--VHADRSRVRQVLTNLIENG 384
Cdd:PRK09303 205 eierLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpsVYADQERIRQVLLNLLDNA 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 385 IAYTG-GGSVRCRV-QRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSREsgGTGLGLSIVKQILQAHGEDIHVE 462
Cdd:PRK09303 285 IKYTPeGGTITLSMlHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTE--GYGIGLSVCRRIVRVHYGQIWVD 362
|
250
....*....|....
gi 1995275685 463 STKGRGTRFWFELP 476
Cdd:PRK09303 363 SEPGQGSCFHFTLP 376
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
368-479 |
1.25e-32 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 120.17 E-value: 1.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 368 ADRSRVRQVLTNLIENGI-AYTGGGSVRCRVQRRlDKVRVEVVDTGQGIDEDHLDRIFERFYRVDpdrSRESGGTGLGLS 446
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALkHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 1995275685 447 IVKQILQAHGEDIHVESTKGRGTRFWFELPYEP 479
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
244-476 |
2.26e-32 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 129.08 E-value: 2.26e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 244 TFREKIEEL----ERMtRLQSEFIGNVSHEVRNPIFSISGYLEALGtPGLDDeqRKMYSEKALTNLNRLQNLFNDLIDIA 319
Cdd:COG5805 269 TEKKEAEELmarsEKL-SIAGQLAAGIAHEIRNPLTSIKGFLQLLQ-PGIED--KEEYFDIMLSELDRIESIISEFLALA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 320 rleyKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSR--FFVHADRSRVRQVLTNLIENGI-AYTGGGSVRCR 396
Cdd:COG5805 345 ----KPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDedPFIYCDENQIKQVFINLIKNAIeAMPNGGTITIH 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 397 VQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:COG5805 421 TEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-476 |
7.59e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 115.25 E-value: 7.59e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 369 DRSRVRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSI 447
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTdTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1995275685 448 VKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
139-476 |
6.66e-30 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 121.25 E-value: 6.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 139 DGQQFFLAALyrPSANLIVQVGqPPPPLYSLAQRSQVVLVLGMILALVLALiGSFIAAYQVTTPLTRISETARRVADGKL 218
Cdd:PRK10604 104 DDQYTFLQRI--PRSHYVLAVG-PVPYLYYLHQMRLLDIALLALIGLSLAF-PVFLWMRPHWQDMLKLEAAAQRLGDGHL 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 219 TGKIQVESraaefqdlAESLNRASDTFREKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQrkmys 298
Cdd:PRK10604 180 AERIHFDE--------GSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQ----- 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 299 ekaltNLNR----LQNLFNDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSRVR 374
Cdd:PRK10604 247 -----ALNRdigqLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLME 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 375 QVLTNLIENGIAYTGGgSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQA 454
Cdd:PRK10604 322 RVLDNLLNNALRYAHS-RVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALA 400
|
330 340
....*....|....*....|..
gi 1995275685 455 HGEDIHVESTKGRGTRFWFELP 476
Cdd:PRK10604 401 MGGSVNCDESELGGARFSFSWP 422
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
155-455 |
5.94e-27 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 113.10 E-value: 5.94e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 155 LIVQVGQPPPPLYSLAQRSQVVLVLGMILA---LVLALigsfiaAYQVTTPLTRISETARRVADGKLTGKIQVESRAAEF 231
Cdd:PRK09470 149 LIRPANSPQSDFINLLFDRPLLLLLVTMLVstpLLLWL------AWSLAKPARKLKNAADEVAQGNLRQHPELETGPQEF 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 232 QDLAESLNRAsdtfrekIEELERMTRLQSEFIGNVSHEVRNPIFSISgyleaLGTPGLddeQRKMYSEKALTNLN----R 307
Cdd:PRK09470 223 RQAGASFNQM-------VTALERMMTSQQRLLSDISHELRTPLTRLQ-----LATALL---RRRQGESKELERIEteaqR 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 308 LQNLFNDLIDIARLEYKEDLiNRSVFDLKDLVDEVAEMLRPKAEEKGLDLE--ADVSRFFVHADRSRVRQVLTNLIENGI 385
Cdd:PRK09470 288 LDSMINDLLVLSRNQQKNHL-ERETFKANSLWSEVLEDAKFEAEQMGKSLTvsAPPGPWPINGNPNALASALENIVRNAL 366
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995275685 386 AYtggGSVRCRVQRRLDK--VRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAH 455
Cdd:PRK09470 367 RY---SHTKIEVAFSVDKdgLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
6.75e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 104.21 E-value: 6.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQI 451
Cdd:cd16952 1 LRSAFSNLVSNAVKYTpPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1995275685 452 LQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
223-484 |
2.98e-25 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 109.61 E-value: 2.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 223 QVESRAAEFQDLAESlnrasdtFREKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKmYSEKAL 302
Cdd:PRK11466 415 QVKARTAELQELVIE-------HRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRD-DLRAIT 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 303 TNLNRLQNLFNDLIDIARLEY--KEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFF---VHADRSRVRQVL 377
Cdd:PRK11466 487 DSGESLLTILNDILDYSAIEAggKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLptaLMGDPRRIRQVI 566
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 378 TNLIENGIAYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRsresGGTGLGLSIVKQILQAHGE 457
Cdd:PRK11466 567 TNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGG 642
|
250 260 270
....*....|....*....|....*....|.
gi 1995275685 458 DIHVESTKGRGTRFWFELPYE----PEPEAV 484
Cdd:PRK11466 643 ELSATSTPEVGSCFCLRLPLRvataPVPKTV 673
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
240-476 |
2.71e-24 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 105.25 E-value: 2.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 240 RASDTFREKIEELERMTRLQSefIGN----VSHEVRNPIFSISGYLEALGT---PGLDDEQ--RKMYSEkaltnLNRLQN 310
Cdd:PRK10364 216 RYLRSRQLLQDEMKRKEKLVA--LGHlaagVAHEIRNPLSSIKGLAKYFAErapAGGEAHQlaQVMAKE-----ADRLNR 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 311 LFNDLIDIARleyKEDLINRSVfDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFF--VHADRSRVRQVLTNLIENGI-AY 387
Cdd:PRK10364 289 VVSELLELVK---PTHLALQAV-DLNDLINHSLQLVSQDANSREIQLRFTANDTLpeIQADPDRLTQVLLNLYLNAIqAI 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 388 TGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFerfyrvDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGR 467
Cdd:PRK10364 365 GQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIF------TPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGK 438
|
....*....
gi 1995275685 468 GTRFWFELP 476
Cdd:PRK10364 439 GATFTLWLP 447
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
231-486 |
5.55e-24 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 105.97 E-value: 5.55e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 231 FQDLAESlnrasdtfREKIEELE-------RMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMYSEKALT 303
Cdd:PRK09959 685 WQDITET--------RDLIHALEvernkaiNATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYA 756
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 304 NLNRLQNLFNDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVS---RFFVHADRSRVRQVLTNL 380
Cdd:PRK09959 757 TGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfpdHYLVKIDPQAFKQVLSNL 836
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 381 IENGIAYTGGGSVR-----CRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPdrSRESGGTGLGLSIVKQILQAH 455
Cdd:PRK09959 837 LSNALKFTTEGAVKittslGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSA--GRQQTGSGLGLMICKELIKNM 914
|
250 260 270
....*....|....*....|....*....|...
gi 1995275685 456 GEDIHVESTKGRGTRFWFELPYE--PEPEAVEA 486
Cdd:PRK09959 915 QGDLSLESHPGIGTTFTITIPVEisQQVATVEA 947
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-476 |
7.28e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 95.95 E-value: 7.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 370 RSRVRQVLTNLIENGI-AYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSresgGTGLGLSIV 448
Cdd:cd16943 1 PSQLNQVLLNLLVNAAqAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 1995275685 449 KQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
3.77e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 93.93 E-value: 3.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYTGGG-----SVRCRvqRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRsrESGGTGLGLSI 447
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrppriEVGAE--DVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSRE--EYEGTGVGLAI 76
|
90 100
....*....|....*....|....*....
gi 1995275685 448 VKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16921 77 VRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
369-476 |
7.23e-23 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 93.33 E-value: 7.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 369 DRSRVRQVLTNLIENGIAYT-GGGSVRCRVQR-RLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLS 446
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTpDGGRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 1995275685 447 IVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
252-483 |
1.28e-22 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 101.68 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 252 LERMTRLQS--EFIGNVSHEVRNPIFSISGYLEAlgtpGLDDEQRKMYSEKALTNLNRLQNLFNDLID-IARLEYKEDLi 328
Cdd:PRK13837 441 LEHARRLEAvgTLASGIAHNFNNILGAILGYAEM----ALNKLARHSRAARYIDEIISAGARARLIIDqILAFGRKGER- 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 329 NRSVFDLKDLVDEVAEMLR----PKAEekgLDLEADVSRFFVHADRSRVRQVLTNLIENGI-AYTGGGSVRCRVQRRL-- 401
Cdd:PRK13837 516 NTKPFDLSELVTEIAPLLRvslpPGVE---LDFDQDQEPAVVEGNPAELQQVLMNLCSNAAqAMDGAGRVDISLSRAKlr 592
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 402 -------------DKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRG 468
Cdd:PRK13837 593 apkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRG 666
|
250
....*....|....*
gi 1995275685 469 TRFWFELPYEPEPEA 483
Cdd:PRK13837 667 TRFDVYLPPSSKVPV 681
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
246-476 |
2.13e-22 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 100.82 E-value: 2.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 246 REKIEE-LERM-------TRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEqrkmySEKALTNLNR----LQNLFN 313
Cdd:PRK10841 426 RVKMEEsLQEMaqaaeqaSQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKG-----VDRLVTAMNNssslLLKIIS 500
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 314 DLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDL----EADVSRFfVHADRSRVRQVLTNLIENGIAYTG 389
Cdd:PRK10841 501 DILDFSKIESEQLKIEPREFSPREVINHITANYLPLVVKKRLGLycfiEPDVPVA-LNGDPMRLQQVISNLLSNAIKFTD 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 390 GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGT 469
Cdd:PRK10841 580 TGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGS 659
|
....*..
gi 1995275685 470 RFWFELP 476
Cdd:PRK10841 660 QFTIRIP 666
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
252-482 |
3.71e-22 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 100.11 E-value: 3.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 252 LERMT--------RLQSE-------FIGNVSHEVRNPIFSISGYLEALgTPGLDDEQRKmYSEKAltNLNRLQ-----NL 311
Cdd:PRK10490 642 LERLTltaseeqaRLASEreqlrnaLLAALSHDLRTPLTVLFGQAEIL-TLDLASEGSP-HARQA--SEIRQQvlnttRL 717
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 312 FNDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRP--KAEEKGLDLEADVSrfFVHADRSRVRQVLTNLIENGIAYTG 389
Cdd:PRK10490 718 VNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPglSGHPINLSLPEPLT--LIHVDGPLFERVLINLLENAVKYAG 795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 390 GGS---VRCRVQRrlDKVRVEVVDTGQGIDEDHLDRIFERFYRVDpdrsRESG--GTGLGLSIVKQILQAHGEDIHVEST 464
Cdd:PRK10490 796 AQAeigIDAHVEG--ERLQLDVWDNGPGIPPGQEQLIFDKFARGN----KESAipGVGLGLAICRAIVEVHGGTIWAENR 869
|
250
....*....|....*...
gi 1995275685 465 KGRGTRFWFELPYEPEPE 482
Cdd:PRK10490 870 PEGGACFRVTLPLETPPE 887
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-472 |
4.54e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 90.93 E-value: 4.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 366 VHADRSRVRQVLTNLIENGIAYTG-GGSVRCRVQ-RRLDKVRVEvvDTGQGIDEDHLDRIFERFYRVDPdrsRESGGTGL 443
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPqGSRVEIKLSaDDGAVIRVE--DNGPGIDEEELEALFERFYRSDG---QNYGGSGL 81
|
90 100
....*....|....*....|....*....
gi 1995275685 444 GLSIVKQILQAHGEDIHVESTKGRGTRFW 472
Cdd:cd16940 82 GLSIVKRIVELHGGQIFLGNAQGGGLEAW 110
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
244-480 |
1.28e-21 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 96.46 E-value: 1.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 244 TFREKIEELERMTRLQS--EFIGNV---SHEVRNPIFSISGYLEAlgtpGLDDEQRKMysekaltnlnrLQNLFNDLidi 318
Cdd:COG3290 169 TFRDRTELERLEEELEGvkELAEALraqRHDFRNHLHTISGLLQL----GEYDEALEY-----------IDEISEEL--- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 319 arleykEDLINRSVFDLKDLVdeVAEMLRPK---AEEKGLDLEADVSRFFVHADRSR--VRQVLTNLIENGIAYTGGGS- 392
Cdd:COG3290 231 ------QELIDSLLSRIGNPV--LAALLLGKaarARERGIDLTIDIDSDLPDLPLSDtdLVTILGNLLDNAIEAVEKLPe 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 393 ----VRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRG 468
Cdd:COG3290 303 eerrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEG 377
|
250
....*....|..
gi 1995275685 469 TRFWFELPYEPE 480
Cdd:COG3290 378 TVFTVRLPKEGE 389
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
9.46e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 86.73 E-value: 9.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYtGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVdpDRSRESGGTGLGLSIVKQIL 452
Cdd:cd16950 1 LKRVLSNLVDNALRY-GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRG--DNARGTSGTGLGLAIVQRIS 77
|
90 100
....*....|....*....|....
gi 1995275685 453 QAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16950 78 DAHGGSLTLANRAGGGLCARIELP 101
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
138-480 |
1.11e-19 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 91.23 E-value: 1.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 138 DDGQQFFLAALYRPSANLIVQVGQPPPPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGK 217
Cdd:COG2972 120 LILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGD 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 218 LTgKIQVESRAaEFQDLAESLNRASDTFREKIEELERMTRLQSEFignvshEVR------NP--IFSIsgyLEALgtpgl 289
Cdd:COG2972 200 LV-RLEVSGND-EIGILARSFNEMVERIKELIEEVYELELEKKEA------ELKalqaqiNPhfLFNT---LNSI----- 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 290 ddeqrKMYSEKAltNLNRLQNLFNDLIDIAR--LEYKEDLINrsvfdLKDLVDEV-----AEMLRpkAEEKgLDLEADVS 362
Cdd:COG2972 264 -----RWLAELE--DPEEAEEMLEALSKLLRysLSKGDELVT-----LEEELELIksyleIQKLR--FGDR-LEVEIEID 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 363 rffVHADRSRV-RQVLTNLIENGI-----AYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFyrvdpdrSR 436
Cdd:COG2972 329 ---EELLDLLIpKLILQPLVENAIehgiePKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SS 398
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1995275685 437 ESGGTGLGLSIVKQILQAH-GED--IHVESTKGRGTRFWFELPYEPE 480
Cdd:COG2972 399 KGEGRGIGLRNVRERLKLYyGEEygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
179-456 |
2.78e-19 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 90.09 E-value: 2.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 179 LGMILALVLALIGSFIAayqvttPLTRISETAR-RVADGklTGKIQVESRAAEFQDLAESLNrasdTFREKIEELerMTR 257
Cdd:PRK10337 171 LPIMLIILMVLLGRELA------PLKKLALALRmRDPDS--ETPLNATGVPSEVRPLVEALN----QLFARTHAM--MVR 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 258 lQSEFIGNVSHEVRNPifsisgyLEALGTP------GLDDEQRKmysEKALTNL----NRLQNLFNDLIDIARLEYKEDL 327
Cdd:PRK10337 237 -ERRFTSDAAHELRSP-------LAALKVQtevaqlSDDDPQAR---KKALLQLhagiDRATRLVDQLLTLSRLDSLDNL 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 328 INRSVFDLKDLV-DEVAEMLRPkAEEKGLDLEADVSrffvhaDRSRVRQ--------VLTNLIENGIAYTGGGSVrcrVQ 398
Cdd:PRK10337 306 QDVAEIPLEDLLqSAVMDIYHT-AQQAGIDVRLTLN------AHPVIRTgqplllslLVRNLLDNAIRYSPQGSV---VD 375
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1995275685 399 RRLDKVRVEVVDTGQGIDEDHLDRIFERFYRvDPdrSRESGGTGLGLSIVKQILQAHG 456
Cdd:PRK10337 376 VTLNARNFTVRDNGPGVTPEALARIGERFYR-PP--GQEATGSGLGLSIVRRIAKLHG 430
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
375-476 |
3.89e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 82.37 E-value: 3.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 375 QVLTNLIENGIAYTGGgSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQA 454
Cdd:cd16949 3 RALENVLRNALRYSPS-KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQ 81
|
90 100
....*....|....*....|..
gi 1995275685 455 HGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16949 82 HGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
1.24e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 80.90 E-value: 1.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYTGGGSVRCR------VQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDrsresgGTGLGLS 446
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERReltirtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 1995275685 447 IVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
177-476 |
1.28e-18 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 86.95 E-value: 1.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 177 LVLGMILALVLALIGSFIAAYQVTTPLTRISET-ARRVADgKLTgKIQVESRAAEFQDLAESLN----RASDTFREkiee 251
Cdd:PRK10755 63 LLVPSLVMVSLTLLICFQAVRWITRPLAELQKElEARTAD-NLT-PIAIHSSTLEIEAVTSALNqlvsRLTSTLDQ---- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 252 lERMtrlqseFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQrkmyseKALTNLNRLQNLFNDLIDIARLE-------YK 324
Cdd:PRK10755 137 -ERL------FTADVAHELRTPLAGIRLHLELLEKQHHIDVA------PLIARLDQMMHTVEQLLQLARAGqsfssghYQ 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 325 E-DLINRSVFDLKDlvdEVAEMLRPKAEEkgLDLEADVSRFFVHADRSRVRQVLTNLIENGIAYT-GGGSVRCRVQRRLD 402
Cdd:PRK10755 204 TvKLLEDVILPSQD---ELSEMLEQRQQT--LLLPESAADITVQGDATLLRLLLRNLVENAHRYSpEGSTITIKLSQEDG 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1995275685 403 KVRVEVVDTGQGIDEDHLDRIFERFYRVDpdrsRESGGTGLGLSIVKQILQAHGEDIHVESTKGR-GTRFWFELP 476
Cdd:PRK10755 279 GAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNRQERsGTRAWVWLP 349
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
1.05e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 78.24 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYTGGgSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQIL 452
Cdd:cd16939 1 MARALDNLLRNALRYAHR-TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....
gi 1995275685 453 QAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWP 103
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
11-476 |
4.11e-17 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 83.42 E-value: 4.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 11 LLPRRASTQTWMVLTFALFVGTAV--VGVGLYVML--------VLRGEMRTAMQETLHDQAdriavqaEQEPDPVRRGRI 80
Cdd:PRK09467 3 FSPRSSFARTLLLIVTLLFISQVVsyLVVLNYAILpslqqfnkVLAYEVRLLFTDQLEDGT-------QLVVPPAFRREI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 81 VdnltelQDLHVSLVTPDTTYRPSPQTAPPFpaDMLVEvsalrNMTEE-----TVRFARhdpddGQQFFLAALYRPSA-N 154
Cdd:PRK09467 76 Y------RELGISLYSNEAAEEAGLRWAQHY--EFLSE-----QMSQQlggptEVRVEV-----GKESPIVWIKTPLApN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 155 LIVQVgqpppPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKIQvESRAAEFQDL 234
Cdd:PRK09467 138 IWVRV-----PLTEIHQGDFSPLFRYTLAIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLR-EYGASEVRSV 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 235 AESLNRASdtfrEKIEELERMTRLqseFIGNVSHEVRNPIFSISgyleaLGTPGLDDEQRKMySEKALTNLNRLQNLFND 314
Cdd:PRK09467 212 TRAFNQMA----AGIKQLEDDRTL---LMAGVSHDLRTPLTRIR-----LATEMMSEEDGYL-AESINKDIEECNAIIEQ 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 315 LIDIARLEYKEDlinRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRffVHADRSRVRQVLTNLIENGIAYtGGGSVR 394
Cdd:PRK09467 279 FIDYLRTGQEMP---MEMADLNALLGEVIAAESGYEREIETALQPGPIE--VPMNPIAIKRALANLVVNAARY-GNGWIK 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 395 CRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRvdPDRSRESGGTGLGLSIVKQILQAHGEDIHVeSTKGRG---TRF 471
Cdd:PRK09467 353 VSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTR--GDSARGSSGTGLGLAIVKRIVDQHNGKVEL-GNSEEGglsARA 429
|
....*
gi 1995275685 472 WFELP 476
Cdd:PRK09467 430 WLPLT 434
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
365-471 |
6.18e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 76.78 E-value: 6.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 365 FVHADRSRVRQVLTNLIENGIAYTGGGSVRCRVQRRLDK-VRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGL 443
Cdd:cd16947 13 YANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKhVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGL 92
|
90 100
....*....|....*....|....*...
gi 1995275685 444 GLSIVKQILQAHGEDIHVESTKGRGTRF 471
Cdd:cd16947 93 GLTITKRLAESMGGSIYVNSKPYEKTVF 120
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
375-476 |
7.89e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 76.07 E-value: 7.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 375 QVLTNLIENGIAYTGGGSVRCRVQR--RLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQIL 452
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGRITVSAmpTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 1995275685 453 QAHGEDIHVES----TKGRGTRFWFELP 476
Cdd:cd16953 83 EAHGGISVAENhnqpGQVIGARFTVQLP 110
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
374-476 |
8.54e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 75.89 E-value: 8.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 374 RQVLTNLIENGIAYTGGGSvRCRVQRRL--DKVRVEVVDTGQGIDEDHLDRIFERFYRVdpDRSRESGGTGLGLSIVKQI 451
Cdd:cd16923 2 QRVFSNLLSNAIKYSPENT-RIYITSFLtdDVVNIMFKNPSSHPLDFKLEKLFERFYRG--DNSRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 1995275685 452 LQAHGEDIHVEStKGRGTRFWFELP 476
Cdd:cd16923 79 IELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-466 |
3.47e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 74.03 E-value: 3.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVD-PDRSRESggTGLGLSIVKQ 450
Cdd:cd16945 5 LRQAINNLLDNAIDFSpEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPrPHSGQKS--TGLGLAFVQE 82
|
90
....*....|....*.
gi 1995275685 451 ILQAHGEDIHVESTKG 466
Cdd:cd16945 83 VAQLHGGRITLRNRPD 98
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
244-480 |
1.67e-15 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 78.80 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 244 TFREKIE---ELERMT--RLQSEFIGNVSHEVRNPIFSISGylealgtpglddeqrkmysekaLTNLNRLQNLFNDLIDI 318
Cdd:PRK11086 319 TFRDKTEvrqLAQRLDgmVNYADALRAQSHEFMNKLHVILG----------------------LLHLKSYDQLEDYILKT 376
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 319 ARlEYKEDlINRSVFDLKDLVdeVAEMLRPK---AEEKGLDLEADVSRFFVHADRSRVRQVLT----NLIENG---IAYT 388
Cdd:PRK11086 377 AN-NYQEE-IGSLLGKIKSPV--IAGFLLGKisrARELGITLIISEDSQLPDSGDEDQVHELItilgNLIENAleaVGGE 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 389 GGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRG 468
Cdd:PRK11086 453 EGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVG 526
|
250
....*....|..
gi 1995275685 469 TRFWFELPYEPE 480
Cdd:PRK11086 527 TQFFVQIPWDGE 538
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
171-468 |
1.12e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 76.65 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 171 QRSQVVLVLGMILALVLALigsFIAAYQV----TTPLTRISETARRVADGKLTGKIQVESRAaEFQDLAESLNRASDTFR 246
Cdd:COG4192 322 QQSGILLLAIALLSLLLAV---LINYFYVrrrlVKRLNALSDAMAAIAAGDLDVPIPVDGND-EIGRIARLLRVFRDQAI 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 247 EKIEELE-----RMTRL------QSEFI------------GNVSHEVRNPIFSISGYLEALGTPGlddEQRKMysEKALT 303
Cdd:COG4192 398 EKTQELEteieeRKRIEknlrqtQDELIqaakmavvgqtmTSLAHELNQPLNAMSMYLFSAKKAL---EQENY--AQLPT 472
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 304 NLNRLQNLFN--DLIdIARLEY---KEDLINRSVfDLKDLVDEVAEML--RPKAEEKGLDLEADVsrfFVHADRSRVRQV 376
Cdd:COG4192 473 SLDKIEGLIErmDKI-IKSLRQfsrKSDTPLQPV-DLRQVIEQAWELVesRAKPQQITLHIPDDL---MVQGDQVLLEQV 547
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 377 LTNLIENGI-AYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEdhLDRIFERFYrvdpdrSRESGGTGLGLSIVKQILQAH 455
Cdd:COG4192 548 LVNLLVNALdAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFT------TTKEVGLGLGLSICRSIMQQF 619
|
330
....*....|...
gi 1995275685 456 GEDIHVESTKGRG 468
Cdd:COG4192 620 GGDLYLASTLERG 632
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-475 |
1.97e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 69.02 E-value: 1.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYTGG---GSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRvdpdrSRESG-GTGLGLSIV 448
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKvenPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 1995275685 449 KQILQAHGEDIHVESTKGRGTRFWFEL 475
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-476 |
4.57e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 68.08 E-value: 4.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 376 VLTNLIENGI-----AYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRvdpdrSRESGGTGLGLSIVKQ 450
Cdd:cd16915 4 IVGNLIDNALdalaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 1995275685 451 ILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-476 |
6.72e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 67.70 E-value: 6.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 376 VLTNLIENGIAYTG-GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDR-SRESggTGLGLSIVKQILQ 453
Cdd:cd16948 9 IIGQIVSNALKYSKqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRnFQES--TGMGLYLVKKLCD 86
|
90 100
....*....|....*....|...
gi 1995275685 454 AHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16948 87 KLGHKIDVESEVGEGTTFTITFP 109
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
259-322 |
7.16e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 66.08 E-value: 7.16e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995275685 259 QSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKmYSEKALTNLNRLQNLFNDLIDIARLE 322
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQRE-YLETILRSAERLLRLINDLLDLSRIE 64
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
259-322 |
3.19e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 64.51 E-value: 3.19e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995275685 259 QSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKmYSEKALTNLNRLQNLFNDLIDIARLE 322
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQRE-YLETILREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
375-476 |
3.24e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 65.88 E-value: 3.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 375 QVLTNLIENG---IAYTGGG-SVRCRVQR--RLDKVR------VEVVDTGQGIDEDHLDRIFERFYRvdpdrSREsGGTG 442
Cdd:cd16918 3 QVFLNLVRNAaqaLAGSGGEiILRTRTQRqvTLGHPRhrlalrVSVIDNGPGIPPDLQDTIFYPMVS-----GRE-NGTG 76
|
90 100 110
....*....|....*....|....*....|....
gi 1995275685 443 LGLSIVKQILQAHGEDIHVESTKGRgTRFWFELP 476
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-471 |
9.86e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 65.35 E-value: 9.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 337 DLVDEVAEMLRPKAEEKGLDLEADVS---RFFVhaDRSRVRQVLTNLIENGIAYtGGGSVRCRVQRRLDKVRVEVVDTGQ 413
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDISpelRFPG--ERNDLMELLGNLLDNACKW-CLEFVEVTARQTDGGLHLIVDDDGP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1995275685 414 GIDEDHLDRIFERFYRVDPDRSresgGTGLGLSIVKQILQAHGEDIHVESTKGRGTRF 471
Cdd:cd16954 78 GVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARF 131
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
257-320 |
1.12e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 63.00 E-value: 1.12e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995275685 257 RLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIAR 320
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-476 |
3.78e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 62.94 E-value: 3.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 369 DRSRVRQVLTNLIENGI-----AYTGGGSVRCRVQR-RLDKVRVEVVDTGQGIDEDHLDRIFErfyrvdPDRSRESGGTG 442
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATE------PYVTTRPKGTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 1995275685 443 LGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-473 |
5.75e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.40 E-value: 5.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 369 DRSRVRQVLTNLIENGIAYT-GGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRvdPDRSRESGG-TGLGLS 446
Cdd:cd16975 1 DTLLLSRALINIISNACQYApEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYR--DDTSRRSGGhYGMGLY 78
|
90 100
....*....|....*....|....*....
gi 1995275685 447 IVKQILQAHGEDIHVESTKGRGT--RFWF 473
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGAevTVKI 107
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
251-485 |
6.23e-11 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 64.95 E-value: 6.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 251 ELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMySEKALTNLNRLQNLFNDLIDIARLEYKEDLINR 330
Cdd:PRK10618 442 EYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPE-LDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQ 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 331 SVFDLKDLVDEVAEMLRPKAEEKGLDL----EADVSRFFvHADRSRVRQVLTNLIENGIAYTGGGSVRCRV---QRRLDK 403
Cdd:PRK10618 521 ELFSLQDLIDEVLPEVLPAIKRKGLQLlihnHLKAEQLR-IGDRDALRKILLLLLNYAITTTAYGKITLEVdqdESSPDR 599
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 404 VRVEVVDTGQGIDEDHLDRIfeRF-YRVDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELPYEPEPE 482
Cdd:PRK10618 600 LTIRILDTGAGVSIKELDNL--HFpFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKMLAADP 677
|
...
gi 1995275685 483 AVE 485
Cdd:PRK10618 678 EVE 680
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
402-476 |
9.33e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 58.93 E-value: 9.33e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1995275685 402 DKVRVEVVDTGQGIDEDHLDRIFERFYRVDPdrsrESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE----VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
339-476 |
4.82e-09 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 54.53 E-value: 4.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 339 VDEVAEMLRPKAEEKGLDLEadvsrffvhaDRSRVRQVL----TNLIENGIAYTGGGSVRCRVQRRLDKVRVEVVDTGQG 414
Cdd:COG2172 11 LGLARRAVRALLRELGLDED----------DADDLVLAVseavTNAVRHAYGGDPDGPVEVELELDPDGLEIEVRDEGPG 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995275685 415 IDEDHLdriferfyrvdPDRSRESGGTGLGLSIVKQILqahgEDIHVESTKGrGTRFWFELP 476
Cdd:COG2172 81 FDPEDL-----------PDPYSTLAEGGRGLFLIRRLM----DEVEYESDPG-GTTVRLVKR 126
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
233-473 |
2.76e-08 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 56.22 E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 233 DLAESLNRAsdtfrEKIEELERMTrlqsefiGNVSHEVRNPIFSISGYLEALGT----PGLDDEQRKMYSEKALTNLNRL 308
Cdd:PRK13557 149 DAEDALRQA-----QKMEALGQLT-------GGIAHDFNNLLQVMSGYLDVIQAalshPDADRGRMARSVENIRAAAERA 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 309 QNLFNDLIDIARleyKEDLINRsVFDLKDLVDEVAEML-RPKAEEKGLDLEADVSRFFVHADRSRVRQVLTNLIENGI-A 386
Cdd:PRK13557 217 ATLTQQLLAFAR---KQRLEGR-VLNLNGLVSGMGELAeRTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARdA 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 387 YTGGGSVRCRVQ----RRLDK-----------VRVEVVDTGQGIDEDHLDRIFERFYRvdpdrSRESG-GTGLGLSIVKQ 450
Cdd:PRK13557 293 MPEGGRVTIRTRnveiEDEDLamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYG 367
|
250 260
....*....|....*....|....*
gi 1995275685 451 ILQAHGEDIHVESTKGRGT--RFWF 473
Cdd:PRK13557 368 FAKQSGGAVRIYSEVGEGTtvRLYF 392
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
6-475 |
1.74e-07 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 53.96 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 6 SIRDALLPRRASTQTWMVLTFALFVGTAVVGVGLYVMLVLRGEMRTAMQETLHDQADRIAVQAEQEPDPVRRGRIVDNLT 85
Cdd:COG2770 43 LLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 86 ELQDLHVSLVTPDTTYRPSPQTAPPFPADMLVEVSALRNMTEETVRFARHDPDDGQQFFLAALYRPSANLIVQVGQPPPP 165
Cdd:COG2770 123 LLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVV 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 166 LYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKIQVESRaAEFQDLAESLNRASDTF 245
Cdd:COG2770 203 LLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRK-DEIGELARAFNRMADSL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 246 REKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYKE 325
Cdd:COG2770 282 RESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLL 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 326 DLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSRVRQVLTNLIENGIAYTGGGSVRCRVQRRLDKVR 405
Cdd:COG2770 362 LLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELA 441
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 406 VEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFEL 475
Cdd:COG2770 442 AAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLL 511
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-476 |
2.06e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 48.98 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 376 VLTNLIENGIAY-----TGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIferfyrvdpdRSRESGGTGLGLSIVKQ 450
Cdd:cd16924 5 TLQPLVENAIQHglsplTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNIL----------GKKPKEGNGIGLYNVHQ 74
|
90 100
....*....|....*....|....*....
gi 1995275685 451 -ILQAHGED--IHVESTKGRGTRFWFELP 476
Cdd:cd16924 75 rLILLFGEDygIHIASEPDKGTRITFTIP 103
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
59-471 |
6.52e-07 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 51.81 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 59 DQADRIAVQAEQEPDPVRRGRIVDNLTELQDLHVSLVTPDTTYRPSPQTAPPFPADMLVEVSALRNMTEETVRFARHDPD 138
Cdd:COG3850 2 RELLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 139 DGQQFFLAALYRPSANLIVQVGQPPPPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKL 218
Cdd:COG3850 82 LLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 219 TGKIQVESRaAEFQDLAESLNRASDTFREKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLEALGTPGLDDEQRKMYS 298
Cdd:COG3850 162 DARVPVSGR-DELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 299 EKALTNLNRLQNLFNDLIDIARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSRVRQVLT 378
Cdd:COG3850 241 LLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 379 NLIENGIAYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSRESGGTGLGLSIVKQILQAHGED 458
Cdd:COG3850 321 QAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQG 400
|
410
....*....|...
gi 1995275685 459 IHVESTKGRGTRF 471
Cdd:COG3850 401 AGLVDVEGGVAGE 413
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
267-476 |
2.36e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 49.69 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 267 SHEVRNPIFSISGYLEALGTpGLDDEQRKMYSEKALTNLNRLQNLFNDLIDIARLEYKedlINRSVFDLKDLVDEVAEML 346
Cdd:PRK11073 138 AHEIKNPLGGLRGAAQLLSK-ALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTH---VTESIHKVAERVVQLVSLE 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 347 RPKAEEKGLDLEADVSRFFVHADRsrVRQVLTNLIENGIAYTG--GGSVRCRV----------QRRLDKVRVEVVDTGQG 414
Cdd:PRK11073 214 LPDNVRLIRDYDPSLPELAHDPDQ--IEQVLLNIVRNALQALGpeGGTITLRTrtafqltlhgERYRLAARIDIEDNGPG 291
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995275685 415 IDEDHLDRIFerfYrvdPDRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRgTRFWFELP 476
Cdd:PRK11073 292 IPPHLQDTLF---Y---PMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
169-252 |
2.48e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 50.02 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 169 LAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGKLTGKIQVESRaAEFQDLAESLNRASDTFREK 248
Cdd:COG0840 176 AAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSK-DEIGQLADAFNRMIENLREL 254
|
....
gi 1995275685 249 IEEL 252
Cdd:COG0840 255 VGQV 258
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
2-476 |
3.16e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.52 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 2 SFVRSIRDALLPRRASTQTWMVLTFALFVGTAVVGVGLYVMLVLRGEMRTAMQETLHDQADRIAVQAEQEPDPVRRGRIV 81
Cdd:COG3920 43 LLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 82 DNLTELQDLHVSLVTPDTTYRPSPQTAPPFPADMLVEVSALRNMTEETVRFARHDPDDGQQFFLAALYRPSANLIVQVGQ 161
Cdd:COG3920 123 ALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLAL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 162 PPPPLYSLAQRSQVVLVLGMILALVLALIGSFIAAYQVTTPLTRISETARRVADGkltgkIQVESRAAEFQDLAESLNRA 241
Cdd:COG3920 203 LLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLL-----LLLLLLLRALLLLAAGIRLV 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 242 SDTFREKIEELERMTRLQSEFIGNVSHEVRNPIFSISGYLeALGTPGLDDEQRKMYSEKALtnlNRLQnlfndliDIARL 321
Cdd:COG3920 278 ITERKRAEEELEASLEEKELLLRELHHRVKNNLQVVSSLL-RLQARRADDPEAREALEESQ---NRIQ-------ALALV 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 322 E---YKEDliNRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSR-----VRQVLTNLIENGIAYTGGGSV 393
Cdd:COG3920 347 HellYQSE--DWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAAVplgliLNELVTNALKHAFLSGEGGRI 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 394 RCRVQRRLDKVRVEVVDTGQGIDEDhldriferfyrVDPDRSResggtGLGLSIVKQILQAHGEDIHVESTKgrGTRFWF 473
Cdd:COG3920 425 RVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTLELDRPE--GTRVRI 486
|
...
gi 1995275685 474 ELP 476
Cdd:COG3920 487 TFP 489
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-476 |
5.36e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 45.14 E-value: 5.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 376 VLTNLIENGIAY-----TGGGSVRCRVQRRLD-KVRVEVVDTGQGIDEDHLDRIferfyrvdpdRSRESGGTGLGLSIVK 449
Cdd:cd16955 5 MIQPLVENAIVHgiqekKGKGVVKISVKKQLKnRLHIAVEDNGIGISPKVIERV----------EQDEMPGNKIGLLNVH 74
|
90 100
....*....|....*....|....*...
gi 1995275685 450 QILQ-AHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16955 75 QRLKlGYGEGLHIRSRPDPGTLIAFYIP 102
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-476 |
8.61e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 44.72 E-value: 8.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 376 VLTNLIENGI--AYTG---GGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYrvdpdrsRESGGTGLGLSIVKQ 450
Cdd:cd16957 5 ALQVLVENAIrhAFPKrkeNNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTV-------TSEKGTGTALENLNR 77
|
90 100
....*....|....*....|....*....
gi 1995275685 451 ILQA-HGED--IHVESTKGRGTRFWFELP 476
Cdd:cd16957 78 RLIGlFGSEacLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
1.01e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 43.70 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIEngiaYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDhldriferfyrvdpdrsRESGGTGLGLSIVKQIL 452
Cdd:cd16917 5 VQEALTNALK----HAGASRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERA 63
|
90 100
....*....|....*....|....
gi 1995275685 453 QAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16917 64 ELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
171-470 |
1.34e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 47.32 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 171 QRSQVV-----LVLGMILALVLALIgsFIAAYQVTTPLTRISETARRVADG---KLTgkiqvESRAAEFQDLAESLNRAS 242
Cdd:PRK10815 184 QRSYMVwswfsYVLLANLLLVIPLL--WLAAWWSLRPIEALAKQVRELEEGereQLD-----PNPPRELTSLVRNLNRLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 243 DTfrekieELERMTRLQSEfIGNVSHEVRNPIFSISGYLEALGTPglddeqRKMYSEKA----LTNLNRLQNLFNDLIDI 318
Cdd:PRK10815 257 KN------ERERYTKYRTT-LTDLTHSLKTPLAVLQSTLRSLRSG------KQMSVEQAepimLEQISRISQQIGYYLHR 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 319 ARLEYKEDLINRSVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSR--FFVhADRSRVRQVLTNLIENGIAYTGGgSVRCR 396
Cdd:PRK10815 324 ASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPeiTFV-GEKNDFMEVMGNVLDNACKYCLE-FVEIS 401
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995275685 397 VQRRLDKVRVEVVDTGQGIDEDHLDRIFERFYRVDPDRSresgGTGLGLSIVKQILQAHGEDIHVESTKGRGTR 470
Cdd:PRK10815 402 ARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGAR 471
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
198-250 |
2.48e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 41.85 E-value: 2.48e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1995275685 198 QVTTPLTRISETARRVADGKLTGKIQVESRaAEFQDLAESLNRASDTFREKIE 250
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGR-DEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
335-476 |
2.88e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 43.56 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 335 LKDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSR-----VRQVLTNLIENGIAYTGGGSVRCRVQRRLDKVRVEVV 409
Cdd:cd16951 1 LGEYINRIASAINAIHAVGDIRINITGDTGPVSSEVATaiglvVNELLQNALKHAFSDREGGTITIRSVVDGDYLRITVI 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1995275685 410 DTGQGIDEDHldriferfyrvdpDRSRESggtGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16951 81 DDGVGLPQDE-------------DWPNKG---SLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
200-240 |
4.70e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 40.51 E-value: 4.70e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1995275685 200 TTPLTRISETARRVADGKLTGKIQVESRaAEFQDLAESLNR 240
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSK-DEIGELARAFNQ 40
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
331-480 |
6.45e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 44.61 E-value: 6.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 331 SVFDLKDLVDEVAEMLRPKAEEKGLDLEADVSRFFVHADRSRVRQ---VLTNLIENGIAYTGGGSVRCRVQRRLDKVRVE 407
Cdd:COG4585 118 PALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELAlyrIVQEALTNALKHAGATRVTVTLEVDDGELTLT 197
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1995275685 408 VVDTGQGIDEDhldriferfyrvdpdrsrESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELPYEPE 480
Cdd:COG4585 198 VRDDGVGFDPE------------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
377-475 |
1.29e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 40.71 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 377 LTNLIENGIAYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLdriferfyrVDPDRSRESGgtGLGLSIVKQILqahg 456
Cdd:cd16936 9 VTNAVRHAYRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRP---------ADPDAGLREG--GRGLALIRALM---- 73
|
90
....*....|....*....
gi 1995275685 457 EDIHVESTkGRGTRFWFEL 475
Cdd:cd16936 74 DEVGYRRT-PGGKTVWLEL 91
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
349-476 |
3.53e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 42.90 E-value: 3.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 349 KAEEKGLDLE----ADVSRFFVHADRSRVRQVLTNLIENGIAYT-----GGGSVRCRVQRRLDKVRVEVVDTGQGIDEDH 419
Cdd:PRK15053 405 RARELGLKMVivpgSQLSQLPPGLDSTEFAAIVGNLLDNAFEASlrsdeGNKIVELFLSDEGDDVVIEVADQGCGVPESL 484
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1995275685 420 LDRIFERFYRVdpdRSRESGGTGLGLSIVKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:PRK15053 485 RDKIFEQGVST---RADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HAMP |
pfam00672 |
HAMP domain; |
194-247 |
3.59e-04 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 38.37 E-value: 3.59e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1995275685 194 IAAYQVTTPLTRISETARRVADGKLTGKIQVESRaAEFQDLAESLNRASDTFRE 247
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGR-DEIGELARAFNQMAERLRE 53
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
380-476 |
3.98e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 39.73 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 380 LIENGIAY-----TGGGSVRCRVQRRLDKVRVEVVDTGQGIDEDHLDRIFerfyrvdpdrSRESGGTGLGLsIVKQILQA 454
Cdd:cd16956 9 IVENAVKHglsglLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARIL----------IRSSNGLGLNL-VDKRLRQA 77
|
90 100
....*....|....*....|....
gi 1995275685 455 HGED--IHVESTKGRGTRFWFELP 476
Cdd:cd16956 78 FGNDygLDIECAPGEGTRITIRLP 101
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
368-470 |
8.82e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 39.28 E-value: 8.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 368 ADRSRVRQVLTNLIENGIAYTGGGSVRCRVQRRLDKVRVEV--VDTGQGIdeDHLDRIFErfyrvdpDRSRESGGTGLGL 445
Cdd:cd16934 21 VRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEIlaVDQGPGI--ADVDEALR-------DGFSTGGGLGLGL 91
|
90 100
....*....|....*....|....*
gi 1995275685 446 SIVKQIlqAHGEDIHveSTKGRGTR 470
Cdd:cd16934 92 GGVRRL--ADEFDLH--SAPGRGTV 112
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
391-476 |
2.14e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 39.10 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 391 GSVRCRVQRRLDKVRVEVVDTGQGIDEDH-LDRIFERFYRVDPDRSR-----------ESG-----------GTGLGLSI 447
Cdd:cd16916 70 GTITLRAEHQGNQVVIEVSDDGRGIDREKiREKAIERGLITADEAATlsddevlnlifAPGfstaeqvtdvsGRGVGMDV 149
|
90 100
....*....|....*....|....*....
gi 1995275685 448 VKQILQAHGEDIHVESTKGRGTRFWFELP 476
Cdd:cd16916 150 VKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
364-471 |
4.39e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 37.44 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 364 FFVHADRSRVRQVLTNLIENGIAYT-GGGSVRCRV------QRRLDK---------------VRVEVVDTgqGIDEDHLD 421
Cdd:cd16938 3 DVVVGDERRVFQVLLHMLGNLLKMRnGGGNITFRVfleggsEDRSDRdwgpwrpsmsdesveIRFEVEIN--DSGSPSIE 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1995275685 422 RIFERFYRvdPDRSRESG-GTGLGLSIVKQILQAHGEDIHVESTKGRGTRF 471
Cdd:cd16938 81 SASMRNSL--NRRYNLSElGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTM 129
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
373-473 |
5.18e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 37.13 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995275685 373 VRQVLTNLIENGIAYTGGGSVRCRVQRRLDKVRVEVVDTGQGIDEdhLDRIFERFYRVDPDRSResggTGLGLSIVKQIL 452
Cdd:cd16942 43 VSEAVTNAIIHGYNNDPNGIVSISVIIEDGVVHLTVRDEGVGIPD--IEEARQPLFTTKPELER----SGMGFTIMENFM 116
|
90 100
....*....|....*....|.
gi 1995275685 453 qahgEDIHVESTKGRGTRFWF 473
Cdd:cd16942 117 ----DEVIVESEVNKGTTVYL 133
|
|
| |
