View
Concise Results
Standard Results
Full Results
CocE/NonD family hydrolase [Mycobacterium gordonae]
Protein Classification
CocE/NonD family hydrolase ( domain architecture ID 11459260 )
CocE/NonD family hydrolase similar to Rhodococcus sp. cocaine esterase that hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth
List of domain hits
Name
Accession
Description
Interval
E-value
COG2936
COG2936 Predicted acyl esterase [General function prediction only];
21-532
2.40e-127
Predicted acyl esterase [General function prediction only];
Pssm-ID: 442179 [Multi-domain]
Cd Length: 555
Bit Score: 384.66
E-value: 2.40e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 21 PQYGCRRDNN V PVA MRDGV T L L AD VH RP - D SQ G RF P AL L AAS PY PR qmqdf GAPAGFIEA G VTDFWVP RGYA H V IANL RG 99
Cdd:COG2936 5 APADVYVKED V WIP MRDGV R L A AD IY RP k D AE G PV P VI L ERT PY GK ----- RDGTAGRDL G PHPYFAE RGYA V V VQDV RG 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 100 T C GS G G T F GFLDAQ E RQ D M YD LVE W V A A QPW CD G N VGMIGISY FAMS QL E AA VE RPP H LKAI F P V A V T A D L Y EAASH H - G 178
Cdd:COG2936 80 T G GS E G E F DPYRVD E QT D G YD TID W L A K QPW SN G K VGMIGISY GGFT QL A AA AD RPP A LKAI V P Q A P T S D R Y DDDHY H g G 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 179 L F SSS F VTPFL A MT G LTS ER ---- S D KL WR S L - P VSLIR R VL H T P rlhkk FATMN gesavtmlrqlik LPHNPH P WD E L W 253
Cdd:COG2936 160 A F LLG F NLGWA A TM G AYK ER ppdp A D AR WR E L l P DDYAD R LE H L P ----- LSDAD ------------- ALGEQL P FW E D W 221
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 254 L D tavn HP TR D EW W D ER N LL PL L KE I DI PV YLGCD W EN V pl H L PS T FAAWKG L SDN A C V R mgmld KFGLTW PW ------- 326
Cdd:COG2936 222 L A ---- HP DY D AF W Q ER S LL ED L DR I KV PV LAVGG W YD V -- F L NG T LRLYEA L RAP A G V P ----- RKLVIG PW thgpwar 290
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 327 ----------- ESMHT EAL A W Y DHWLKG R D T GI TEG PPVR YFLP GA DE WRT AES WPPP E A TYREFA L RAD G T LS ED -- EG 393
Cdd:COG2936 291 gqlgplfgata IDFLQ EAL R W F DHWLKG I D N GI EDE PPVR VYVM GA GR WRT EDD WPPP G A RPTRLY L GPG G G LS TE ap AA 370
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 394 TP G ACE Y L --------- VL G AG LG RVK P S ---- A IDP P AL L TW T S APLT G DL DLV G DFEL RL VA S AT A M D TAWM V T L Q DV 460
Cdd:COG2936 371 AA G PDT Y V ydpadpvpt TG G EL LG PEG P A dqrf A EAR P DV L VF T T APLT E DL EIA G PPTA RL FV S SD A P D ADFV V R L I DV 450
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1997081558 461 APDG HV T D VT A G W LR ASL R E vdqaa S R pgapvlpc RN P QAVPI GE DV E YR I P L VAN A RRLRP GHRIR LVLA S 532
Cdd:COG2936 451 APDG RS T N VT D G I LR LRY R D ----- S F -------- EK P EPLVP GE VY E VT I E L WPT A HVFKA GHRIR VQVS S 509
Name
Accession
Description
Interval
E-value
COG2936
COG2936 Predicted acyl esterase [General function prediction only];
21-532
2.40e-127
Predicted acyl esterase [General function prediction only];
Pssm-ID: 442179 [Multi-domain]
Cd Length: 555
Bit Score: 384.66
E-value: 2.40e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 21 PQYGCRRDNN V PVA MRDGV T L L AD VH RP - D SQ G RF P AL L AAS PY PR qmqdf GAPAGFIEA G VTDFWVP RGYA H V IANL RG 99
Cdd:COG2936 5 APADVYVKED V WIP MRDGV R L A AD IY RP k D AE G PV P VI L ERT PY GK ----- RDGTAGRDL G PHPYFAE RGYA V V VQDV RG 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 100 T C GS G G T F GFLDAQ E RQ D M YD LVE W V A A QPW CD G N VGMIGISY FAMS QL E AA VE RPP H LKAI F P V A V T A D L Y EAASH H - G 178
Cdd:COG2936 80 T G GS E G E F DPYRVD E QT D G YD TID W L A K QPW SN G K VGMIGISY GGFT QL A AA AD RPP A LKAI V P Q A P T S D R Y DDDHY H g G 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 179 L F SSS F VTPFL A MT G LTS ER ---- S D KL WR S L - P VSLIR R VL H T P rlhkk FATMN gesavtmlrqlik LPHNPH P WD E L W 253
Cdd:COG2936 160 A F LLG F NLGWA A TM G AYK ER ppdp A D AR WR E L l P DDYAD R LE H L P ----- LSDAD ------------- ALGEQL P FW E D W 221
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 254 L D tavn HP TR D EW W D ER N LL PL L KE I DI PV YLGCD W EN V pl H L PS T FAAWKG L SDN A C V R mgmld KFGLTW PW ------- 326
Cdd:COG2936 222 L A ---- HP DY D AF W Q ER S LL ED L DR I KV PV LAVGG W YD V -- F L NG T LRLYEA L RAP A G V P ----- RKLVIG PW thgpwar 290
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 327 ----------- ESMHT EAL A W Y DHWLKG R D T GI TEG PPVR YFLP GA DE WRT AES WPPP E A TYREFA L RAD G T LS ED -- EG 393
Cdd:COG2936 291 gqlgplfgata IDFLQ EAL R W F DHWLKG I D N GI EDE PPVR VYVM GA GR WRT EDD WPPP G A RPTRLY L GPG G G LS TE ap AA 370
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 394 TP G ACE Y L --------- VL G AG LG RVK P S ---- A IDP P AL L TW T S APLT G DL DLV G DFEL RL VA S AT A M D TAWM V T L Q DV 460
Cdd:COG2936 371 AA G PDT Y V ydpadpvpt TG G EL LG PEG P A dqrf A EAR P DV L VF T T APLT E DL EIA G PPTA RL FV S SD A P D ADFV V R L I DV 450
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1997081558 461 APDG HV T D VT A G W LR ASL R E vdqaa S R pgapvlpc RN P QAVPI GE DV E YR I P L VAN A RRLRP GHRIR LVLA S 532
Cdd:COG2936 451 APDG RS T N VT D G I LR LRY R D ----- S F -------- EK P EPLVP GE VY E VT I E L WPT A HVFKA GHRIR VQVS S 509
/NonD
TIGR00976 putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes ...
33-532
2.49e-84
putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273375 [Multi-domain]
Cd Length: 550
Bit Score: 273.22
E-value: 2.49e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 33 V A MRDG VT L LA DV H RP DSQ G RF P AL L AAS PY PRQMQ dfga PAGFIEAGVTDFW V PR GYA H VI ANL RG TCG S G G T F GF L DA 112
Cdd:TIGR00976 1 V P MRDG TR L AI DV Y RP AGG G PV P VI L SRT PY GKDAG ---- LRWGLDKTEPAWF V AQ GYA V VI QDT RG RGA S E G E F DL L GS 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 113 Q E RQ D M YDLV E W V A A QPWCDGNVGM I G I SY F A MS QL E AAV ER PP H L K AI F P VAVTA DLY EAASHH G LFSSSFVTPFL A MT 192
Cdd:TIGR00976 77 D E AA D G YDLV D W I A K QPWCDGNVGM L G V SY L A VT QL L AAV LQ PP A L R AI A P QEGVW DLY RDIAFP G ALRLDVLLGWW A LL 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 193 GLT S E R SDKLW R SL pvslir R VLHTP RL HKKFATMNGESAV T MLRQLIK L PHNPHP W DE lwldta V NHPTR DE W W DERN L 272
Cdd:TIGR00976 157 ATD S M R PRADD R PP ------ R YAAAA RL AQSYDDCQTALSH T PRSSVLA L DRFIGW W IQ ------ V VDDDY DE S W VSIS L 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 273 LPL L KEI D I P VYLGCD W ENV pl H LPSTFAAWKGLSDNACV R M -- G MLD ----------- KF G LTWPWESMHT E A LA WY D H 339
Cdd:TIGR00976 225 WRD L GGS D V P TLVTGG W YDN -- H SRGSIRLFLAVHRGGAQ R L vv G PWT hsglggrvgdg NY G MAALSWVDEA E Q LA FF D R 302
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 340 W LKG RD TG ITEG P P VR Y F LP G A D E WR TAES WP P P EATYREFA L --------- RAD G T LS EDEG -- T P GA CE YL V ------ 402
Cdd:TIGR00976 303 H LKG GT TG VRSE P K VR L F TM G D D A WR AETT WP L P GTRTTPYY L ggsygtadg ASG G A LS TAPP sp T E GA DP YL Y dpwdpv 382
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 403 --------- L G AGL G RV K PSA I - D PPAL LT W TS A PLT GD L DLV G DFEL RL V A SAT A M D TAWM V T L Q DV A PDG HVTDVTA G 472
Cdd:TIGR00976 383 pslggqlsg A G GPA G PA K QDR I d D RDDV LT Y TS E PLT EP L EVT G TVRV RL F A RSD A P D GDFA V K L T DV D PDG RAIALDE G 462
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 473 WL R A slrevdqaasrpgapvlpc R NPQAVPI GE DV E YR I P L V A N A RRLR PGHR I R LVLA S 532
Cdd:TIGR00976 463 IC R V ------------------- R YRRTSVN GE IY E VD I D L G A T A NLFA PGHR L R VEVG S 503
Peptidase_S15
pfam02129 X-Pro dipeptidyl-peptidase (S15 family);
37-309
3.33e-46
X-Pro dipeptidyl-peptidase (S15 family);
Pssm-ID: 396621 [Multi-domain]
Cd Length: 264
Bit Score: 163.28
E-value: 3.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 37 DGV T L L AD VH RP DSQ G R - F PALL AA SPY p RQMQ D FGAPAGFIEAGVT df WVP RGYA H V IANL RGT C GS G G T F GFLDA QE R 115
Cdd:pfam02129 1 DGV R L A AD IY RP TKT G G p V PALL TR SPY - GARR D GASDLALAHPEWE -- FAA RGYA V V YQDV RGT G GS E G V F TVGGP QE A 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 116 Q D MY D LVE W V A A QPWC D G N VGM I GISY FAMS QL E AA VER PP H LKAI F P VAVTA DLY EAASHH G LFSSSFVTPFLAMTG L T 195
Cdd:pfam02129 78 A D GK D VID W L A G QPWC N G K VGM T GISY LGTT QL A AA ATG PP G LKAI A P ESGIS DLY DYYREG G AVRAPGGLGWEDLDL L A 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 196 SERSDKLWRSLPVSLIRRVLH tprlhkkfatmngesavtmlr QLIKLPHNPHPWDELW L DTAVNHPTR D EW W DE RN L L PL 275
Cdd:pfam02129 158 EALTSRRADDGDAYRAAARYE --------------------- AAGDELLAELDRQLFL L EWLLQTGDY D AF W QD RN Y L ED 216
250 260 270
....*....|....*....|....*....|....
gi 1997081558 276 LKEIDI PV Y L GCD W ENVP l HLPSTFAAWKG L SDN 309
Cdd:pfam02129 217 ADKVKA PV L L VGG W QDWN - VKNGAIKLYEA L RAP 249
PepX_C
smart00939 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; This domain is found at the ...
352-552
8.60e-34
X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; This domain is found at the C-terminus of cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). The domain, which is a beta sandwich, is also found in serine peptidases belonging to MEROPS peptidase family S15: Xaa-Pro dipeptidyl-peptidases. Members of this entry, that are not characterised as peptidases, show extensive low-level similarity to the Xaa-Pro dipeptidyl-peptidases.
Pssm-ID: 214924 [Multi-domain]
Cd Length: 214
Bit Score: 127.90
E-value: 8.60e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 352 PPVR YFLP G -- ADE WR TAES WP P P EA -- TYREFA L RAD G TL ------ SEDEGT P GACEY L V L G AG LGRVKPSAI D PPAL L 421
Cdd:smart00939 1 PPVR LYQR G sr EGR WR SEPA WP S P GP gt RLTRLY L GPG G GG pdlfvs DPADPV P TYGGP L S L A AG DDLPGDQLE D RADV L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 422 TW T S APLT G DL DLV G DFE L R L VA S ATAM D TAWM V T L Q DV A PD -- G HVTD VT A GWLR A S L R EV D Q aasrpgapvlpcr N P Q 499
Cdd:smart00939 81 VF T T APLT E DL EIL G APK L T L TV S SDGP D ADLF V R L S DV D PD gd G RSRN VT K GWLR L S N R KS D D ------------- E P E 147
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1997081558 500 AVPI GE DVEYR I P L VAN A RRLRP GHR I RL VLA S D D Q --- D PSIPAIMNF R H A SVGT 552
Cdd:smart00939 148 PLEP GE VYTVT I E L QPT A YTFPA GHR L RL SIS S S D F plt D RNPGTPEDT R D A THTI 203
PRK05371
PRK05371 x-prolyl-dipeptidyl aminopeptidase; Provisional
36-536
1.12e-23
x-prolyl-dipeptidyl aminopeptidase; Provisional
Pssm-ID: 235435 [Multi-domain]
Cd Length: 767
Bit Score: 105.86
E-value: 1.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 36 R DG VT -- LLADVH RP --- D S QGRF P ALLA ASPY ------------------------- PR Q MQDFGAPAGFIEA G VT --- 82
Cdd:PRK05371 183 Q DG KL dl VKVTIV RP ket A S GLKV P VIMT ASPY yqgtndvandkklhnvdvelyakpp RA Q FTPLKTQPRKLPV G PA ees 262
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 83 ---------- D FWV PRG Y A H V IANLR GT C GS G G -- T F G fl D A QE RQD M YDLVE W ---------------- V A A q P W CD G N 134
Cdd:PRK05371 263 fthinsysln D YFL PRG F A V V YVSGI GT R GS D G cp T T G -- D Y QE IES M KAVID W lngrataytdrtrgke V K A - D W SN G K 339
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 135 V G M I G I SY FAMSQLEA A VERPPH L KA I F P V A VTADL Y EAASHH GL fsssf V T pfl A MT G LTS E RS D K L wrslpvslirrv 214
Cdd:PRK05371 340 V A M T G K SY LGTLPNAV A TTGVEG L ET I I P E A AISSW Y DYYREN GL ----- V R --- A PG G YQG E DL D V L ------------ 399
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 215 lhtprlhkkfatmnge SAV T ML R Q L IKLPHNP H P -- WDE L w L DTAVNHPT R ----- DEW WD E RN L L PLLKE I DIP V YL -- 285
Cdd:PRK05371 400 ---------------- AEL T YS R N L LAGDYLR H N ea CEK L - L AELTAAQD R ktgdy NDF WD D RN Y L KDADK I KAS V LV vh 462
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 286 G C - DW e NV - P LH lps TFAA W KG L SD N ACVR --------- MGMLDKFGLTWP w ES M H teal AW YD H W L K G R D T G ITEGP P V 354
Cdd:PRK05371 463 G L n DW - NV k P KQ --- VYQW W DA L PE N GVPK klflhqggh VYPNNWQSIDFR - DT M N ---- AW FT H K L L G I D N G VENEL P A 533
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 355 RYFL -- PGADE W RTAES WP P PEA --- T YREFALRAD G T L SEDEGTPGAC E YLVLG A GLGRVK - PSAIDPP A L L TWTSA PL 428
Cdd:PRK05371 534 VIWQ dn TTPQT W HKEAD WP A PEA tpv T LLAGGGGQG G G L ILNHYGGETF E RYTDD A RAFKLD l AAGKSGA A R L IFITP PL 613
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 429 T G DL DLV G DFE L R L --- VASATAMDT A WM V ----------------------------- T L QDVA - PDGHVTDV T A GW L - 474
Cdd:PRK05371 614 T K DL RIS G TPK L T L rvk SSTNKGNLS A QL V dygpkkrltdtpailgrrsldngynfgre D L REFP f RETPYRII T R GW A n 693
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1997081558 475 --- R A SL RE V D qaasrpga P VL P crnpqavpi G EDVEYRIP L VANARR L RP GH RIR LVL A S D D QD 536
Cdd:PRK05371 694 lqn R K SL LT V E -------- P IT P --------- G KWYDVTFD L QPTDYV L PA GH QLG LVL Y S T D FE 741
Name
Accession
Description
Interval
E-value
COG2936
COG2936 Predicted acyl esterase [General function prediction only];
21-532
2.40e-127
Predicted acyl esterase [General function prediction only];
Pssm-ID: 442179 [Multi-domain]
Cd Length: 555
Bit Score: 384.66
E-value: 2.40e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 21 PQYGCRRDNN V PVA MRDGV T L L AD VH RP - D SQ G RF P AL L AAS PY PR qmqdf GAPAGFIEA G VTDFWVP RGYA H V IANL RG 99
Cdd:COG2936 5 APADVYVKED V WIP MRDGV R L A AD IY RP k D AE G PV P VI L ERT PY GK ----- RDGTAGRDL G PHPYFAE RGYA V V VQDV RG 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 100 T C GS G G T F GFLDAQ E RQ D M YD LVE W V A A QPW CD G N VGMIGISY FAMS QL E AA VE RPP H LKAI F P V A V T A D L Y EAASH H - G 178
Cdd:COG2936 80 T G GS E G E F DPYRVD E QT D G YD TID W L A K QPW SN G K VGMIGISY GGFT QL A AA AD RPP A LKAI V P Q A P T S D R Y DDDHY H g G 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 179 L F SSS F VTPFL A MT G LTS ER ---- S D KL WR S L - P VSLIR R VL H T P rlhkk FATMN gesavtmlrqlik LPHNPH P WD E L W 253
Cdd:COG2936 160 A F LLG F NLGWA A TM G AYK ER ppdp A D AR WR E L l P DDYAD R LE H L P ----- LSDAD ------------- ALGEQL P FW E D W 221
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 254 L D tavn HP TR D EW W D ER N LL PL L KE I DI PV YLGCD W EN V pl H L PS T FAAWKG L SDN A C V R mgmld KFGLTW PW ------- 326
Cdd:COG2936 222 L A ---- HP DY D AF W Q ER S LL ED L DR I KV PV LAVGG W YD V -- F L NG T LRLYEA L RAP A G V P ----- RKLVIG PW thgpwar 290
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 327 ----------- ESMHT EAL A W Y DHWLKG R D T GI TEG PPVR YFLP GA DE WRT AES WPPP E A TYREFA L RAD G T LS ED -- EG 393
Cdd:COG2936 291 gqlgplfgata IDFLQ EAL R W F DHWLKG I D N GI EDE PPVR VYVM GA GR WRT EDD WPPP G A RPTRLY L GPG G G LS TE ap AA 370
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 394 TP G ACE Y L --------- VL G AG LG RVK P S ---- A IDP P AL L TW T S APLT G DL DLV G DFEL RL VA S AT A M D TAWM V T L Q DV 460
Cdd:COG2936 371 AA G PDT Y V ydpadpvpt TG G EL LG PEG P A dqrf A EAR P DV L VF T T APLT E DL EIA G PPTA RL FV S SD A P D ADFV V R L I DV 450
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1997081558 461 APDG HV T D VT A G W LR ASL R E vdqaa S R pgapvlpc RN P QAVPI GE DV E YR I P L VAN A RRLRP GHRIR LVLA S 532
Cdd:COG2936 451 APDG RS T N VT D G I LR LRY R D ----- S F -------- EK P EPLVP GE VY E VT I E L WPT A HVFKA GHRIR VQVS S 509
/NonD
TIGR00976 putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes ...
33-532
2.49e-84
putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273375 [Multi-domain]
Cd Length: 550
Bit Score: 273.22
E-value: 2.49e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 33 V A MRDG VT L LA DV H RP DSQ G RF P AL L AAS PY PRQMQ dfga PAGFIEAGVTDFW V PR GYA H VI ANL RG TCG S G G T F GF L DA 112
Cdd:TIGR00976 1 V P MRDG TR L AI DV Y RP AGG G PV P VI L SRT PY GKDAG ---- LRWGLDKTEPAWF V AQ GYA V VI QDT RG RGA S E G E F DL L GS 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 113 Q E RQ D M YDLV E W V A A QPWCDGNVGM I G I SY F A MS QL E AAV ER PP H L K AI F P VAVTA DLY EAASHH G LFSSSFVTPFL A MT 192
Cdd:TIGR00976 77 D E AA D G YDLV D W I A K QPWCDGNVGM L G V SY L A VT QL L AAV LQ PP A L R AI A P QEGVW DLY RDIAFP G ALRLDVLLGWW A LL 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 193 GLT S E R SDKLW R SL pvslir R VLHTP RL HKKFATMNGESAV T MLRQLIK L PHNPHP W DE lwldta V NHPTR DE W W DERN L 272
Cdd:TIGR00976 157 ATD S M R PRADD R PP ------ R YAAAA RL AQSYDDCQTALSH T PRSSVLA L DRFIGW W IQ ------ V VDDDY DE S W VSIS L 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 273 LPL L KEI D I P VYLGCD W ENV pl H LPSTFAAWKGLSDNACV R M -- G MLD ----------- KF G LTWPWESMHT E A LA WY D H 339
Cdd:TIGR00976 225 WRD L GGS D V P TLVTGG W YDN -- H SRGSIRLFLAVHRGGAQ R L vv G PWT hsglggrvgdg NY G MAALSWVDEA E Q LA FF D R 302
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 340 W LKG RD TG ITEG P P VR Y F LP G A D E WR TAES WP P P EATYREFA L --------- RAD G T LS EDEG -- T P GA CE YL V ------ 402
Cdd:TIGR00976 303 H LKG GT TG VRSE P K VR L F TM G D D A WR AETT WP L P GTRTTPYY L ggsygtadg ASG G A LS TAPP sp T E GA DP YL Y dpwdpv 382
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 403 --------- L G AGL G RV K PSA I - D PPAL LT W TS A PLT GD L DLV G DFEL RL V A SAT A M D TAWM V T L Q DV A PDG HVTDVTA G 472
Cdd:TIGR00976 383 pslggqlsg A G GPA G PA K QDR I d D RDDV LT Y TS E PLT EP L EVT G TVRV RL F A RSD A P D GDFA V K L T DV D PDG RAIALDE G 462
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 473 WL R A slrevdqaasrpgapvlpc R NPQAVPI GE DV E YR I P L V A N A RRLR PGHR I R LVLA S 532
Cdd:TIGR00976 463 IC R V ------------------- R YRRTSVN GE IY E VD I D L G A T A NLFA PGHR L R VEVG S 503
Peptidase_S15
pfam02129 X-Pro dipeptidyl-peptidase (S15 family);
37-309
3.33e-46
X-Pro dipeptidyl-peptidase (S15 family);
Pssm-ID: 396621 [Multi-domain]
Cd Length: 264
Bit Score: 163.28
E-value: 3.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 37 DGV T L L AD VH RP DSQ G R - F PALL AA SPY p RQMQ D FGAPAGFIEAGVT df WVP RGYA H V IANL RGT C GS G G T F GFLDA QE R 115
Cdd:pfam02129 1 DGV R L A AD IY RP TKT G G p V PALL TR SPY - GARR D GASDLALAHPEWE -- FAA RGYA V V YQDV RGT G GS E G V F TVGGP QE A 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 116 Q D MY D LVE W V A A QPWC D G N VGM I GISY FAMS QL E AA VER PP H LKAI F P VAVTA DLY EAASHH G LFSSSFVTPFLAMTG L T 195
Cdd:pfam02129 78 A D GK D VID W L A G QPWC N G K VGM T GISY LGTT QL A AA ATG PP G LKAI A P ESGIS DLY DYYREG G AVRAPGGLGWEDLDL L A 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 196 SERSDKLWRSLPVSLIRRVLH tprlhkkfatmngesavtmlr QLIKLPHNPHPWDELW L DTAVNHPTR D EW W DE RN L L PL 275
Cdd:pfam02129 158 EALTSRRADDGDAYRAAARYE --------------------- AAGDELLAELDRQLFL L EWLLQTGDY D AF W QD RN Y L ED 216
250 260 270
....*....|....*....|....*....|....
gi 1997081558 276 LKEIDI PV Y L GCD W ENVP l HLPSTFAAWKG L SDN 309
Cdd:pfam02129 217 ADKVKA PV L L VGG W QDWN - VKNGAIKLYEA L RAP 249
PepX_C
smart00939 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; This domain is found at the ...
352-552
8.60e-34
X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; This domain is found at the C-terminus of cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). The domain, which is a beta sandwich, is also found in serine peptidases belonging to MEROPS peptidase family S15: Xaa-Pro dipeptidyl-peptidases. Members of this entry, that are not characterised as peptidases, show extensive low-level similarity to the Xaa-Pro dipeptidyl-peptidases.
Pssm-ID: 214924 [Multi-domain]
Cd Length: 214
Bit Score: 127.90
E-value: 8.60e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 352 PPVR YFLP G -- ADE WR TAES WP P P EA -- TYREFA L RAD G TL ------ SEDEGT P GACEY L V L G AG LGRVKPSAI D PPAL L 421
Cdd:smart00939 1 PPVR LYQR G sr EGR WR SEPA WP S P GP gt RLTRLY L GPG G GG pdlfvs DPADPV P TYGGP L S L A AG DDLPGDQLE D RADV L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 422 TW T S APLT G DL DLV G DFE L R L VA S ATAM D TAWM V T L Q DV A PD -- G HVTD VT A GWLR A S L R EV D Q aasrpgapvlpcr N P Q 499
Cdd:smart00939 81 VF T T APLT E DL EIL G APK L T L TV S SDGP D ADLF V R L S DV D PD gd G RSRN VT K GWLR L S N R KS D D ------------- E P E 147
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1997081558 500 AVPI GE DVEYR I P L VAN A RRLRP GHR I RL VLA S D D Q --- D PSIPAIMNF R H A SVGT 552
Cdd:smart00939 148 PLEP GE VYTVT I E L QPT A YTFPA GHR L RL SIS S S D F plt D RNPGTPEDT R D A THTI 203
PepX_C
pfam08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; This domain contains a beta ...
347-540
3.26e-29
X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; This domain contains a beta sandwich domain.
Pssm-ID: 400714 [Multi-domain]
Cd Length: 216
Bit Score: 115.20
E-value: 3.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 347 G ITEG PPVR YF - L P G A D E WRT AES WPPP EAT Y REFA L RA DG TLSE D EG T PG A CEY L VLGAGLGRV --- K P SAIDPPAL L T 422
Cdd:pfam08530 2 G VEDT PPVR VQ d L D G G D T WRT EPA WPPP NTQ Y TTLY L GP DG LGTT D GL T LS A TAP L SDDFSASER yly D P TNEERDDR L A 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 423 W T S APL TG D LD LVG DFELR L VA S AT A M D TAWM VTL Q DV A PDG HV T DV T A GWLRAS L R EV D QAAS rpga P VL P crnpqavp 502
Cdd:pfam08530 82 F T T APL AE D TE LVG IPKAK L RV S SD A P D ADLF VTL S DV D PDG TE T VI T K GWLRAS N R AS D EESE ---- P LE P -------- 149
170 180 190
....*....|....*....|....*....|....*...
gi 1997081558 503 i GE DVEYR I P L VAN A RRLRP GHR I RLV LA S D D QDPSIP 540
Cdd:pfam08530 150 - GE FYDLE I E L QPT A YVFPK GHR L RLV VS S S D FPGTLR 186
PRK05371
PRK05371 x-prolyl-dipeptidyl aminopeptidase; Provisional
36-536
1.12e-23
x-prolyl-dipeptidyl aminopeptidase; Provisional
Pssm-ID: 235435 [Multi-domain]
Cd Length: 767
Bit Score: 105.86
E-value: 1.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 36 R DG VT -- LLADVH RP --- D S QGRF P ALLA ASPY ------------------------- PR Q MQDFGAPAGFIEA G VT --- 82
Cdd:PRK05371 183 Q DG KL dl VKVTIV RP ket A S GLKV P VIMT ASPY yqgtndvandkklhnvdvelyakpp RA Q FTPLKTQPRKLPV G PA ees 262
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 83 ---------- D FWV PRG Y A H V IANLR GT C GS G G -- T F G fl D A QE RQD M YDLVE W ---------------- V A A q P W CD G N 134
Cdd:PRK05371 263 fthinsysln D YFL PRG F A V V YVSGI GT R GS D G cp T T G -- D Y QE IES M KAVID W lngrataytdrtrgke V K A - D W SN G K 339
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 135 V G M I G I SY FAMSQLEA A VERPPH L KA I F P V A VTADL Y EAASHH GL fsssf V T pfl A MT G LTS E RS D K L wrslpvslirrv 214
Cdd:PRK05371 340 V A M T G K SY LGTLPNAV A TTGVEG L ET I I P E A AISSW Y DYYREN GL ----- V R --- A PG G YQG E DL D V L ------------ 399
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 215 lhtprlhkkfatmnge SAV T ML R Q L IKLPHNP H P -- WDE L w L DTAVNHPT R ----- DEW WD E RN L L PLLKE I DIP V YL -- 285
Cdd:PRK05371 400 ---------------- AEL T YS R N L LAGDYLR H N ea CEK L - L AELTAAQD R ktgdy NDF WD D RN Y L KDADK I KAS V LV vh 462
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 286 G C - DW e NV - P LH lps TFAA W KG L SD N ACVR --------- MGMLDKFGLTWP w ES M H teal AW YD H W L K G R D T G ITEGP P V 354
Cdd:PRK05371 463 G L n DW - NV k P KQ --- VYQW W DA L PE N GVPK klflhqggh VYPNNWQSIDFR - DT M N ---- AW FT H K L L G I D N G VENEL P A 533
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 355 RYFL -- PGADE W RTAES WP P PEA --- T YREFALRAD G T L SEDEGTPGAC E YLVLG A GLGRVK - PSAIDPP A L L TWTSA PL 428
Cdd:PRK05371 534 VIWQ dn TTPQT W HKEAD WP A PEA tpv T LLAGGGGQG G G L ILNHYGGETF E RYTDD A RAFKLD l AAGKSGA A R L IFITP PL 613
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 429 T G DL DLV G DFE L R L --- VASATAMDT A WM V ----------------------------- T L QDVA - PDGHVTDV T A GW L - 474
Cdd:PRK05371 614 T K DL RIS G TPK L T L rvk SSTNKGNLS A QL V dygpkkrltdtpailgrrsldngynfgre D L REFP f RETPYRII T R GW A n 693
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1997081558 475 --- R A SL RE V D qaasrpga P VL P crnpqavpi G EDVEYRIP L VANARR L RP GH RIR LVL A S D D QD 536
Cdd:PRK05371 694 lqn R K SL LT V E -------- P IT P --------- G KWYDVTFD L QPTDYV L PA GH QLG LVL Y S T D FE 741
DAP2
COG1506 Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
36-218
3.57e-11
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
Pssm-ID: 441115 [Multi-domain]
Cd Length: 234
Bit Score: 63.50
E-value: 3.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 36 R DG V TL LADVHR P DSQGRF P ALLAASPY P - RQMQD F GAP A gfieagvt DFWVP RGYA HVIANL RG tcg S G GTF G FLDAQ E 114
Cdd:COG1506 5 A DG T TL PGWLYL P ADGKKY P VVVYVHGG P g SRDDS F LPL A -------- QALAS RGYA VLAPDY RG --- Y G ESA G DWGGD E 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 115 RQ D MYDLVEWV AA Q P WC D GN - V G MI G I SY FAMSQ L E AA VER P PHL KA IFPV A VTA DL YEAASHHGLFSS sfvtpfl AMT G 193
Cdd:COG1506 74 VD D VLAAIDYL AA R P YV D PD r I G IY G H SY GGYMA L L AA ARH P DRF KA AVAL A GVS DL RSYYGTTREYTE ------- RLM G 146
170 180
....*....|....*....|....*
gi 1997081558 194 LTS E RSDKLWRSL P VSLIRR v L H TP 218
Cdd:COG1506 147 GPW E DPEAYAARS P LAYADK - L K TP 170
FrsA
COG1073 Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
36-177
1.89e-05
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];
Pssm-ID: 440691 [Multi-domain]
Cd Length: 253
Bit Score: 46.45
E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 36 RDG VT L LA D VHR P - DSQGRF PA LLA A SPY --- PR Q MQDFGA pagfieagvtd FWVPR G YAHVIANL RG TCG S G G TFGFLD 111
Cdd:COG1073 18 RDG IK L AG D LYL P a GASKKY PA VVV A HGN ggv KE Q RALYAQ ----------- RLAEL G FNVLAFDY RG YGE S E G EPREEG 86
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1997081558 112 AQ ER Q D MYDL V EWVAAQ P WC D GN - V G MI GIS YFAMSQ L E AA VER p P HL KA IFPVAVTAD L YEA A SHH 177
Cdd:COG1073 87 SP ER R D ARAA V DYLRTL P GV D PE r I G LL GIS LGGGYA L N AA ATD - P RV KA VILDSPFTS L EDL A AQR 152
DLH
COG0412 Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
31-163
2.15e-05
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440181 [Multi-domain]
Cd Length: 226
Bit Score: 46.11
E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 31 V PVAMR DGVTL LADVH RP DSQ G RF P ALLAA spyprqm QDFGAPAGF I EA g V TDFWVPR GY AHVIAN L R G TC G S G GTFG -- 108
Cdd:COG0412 6 V TIPTP DGVTL PGYLA RP AGG G PR P GVVVL ------- HEIFGLNPH I RD - V ARRLAAA GY VVLAPD L Y G RG G P G DDPD ea 77
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1997081558 109 ------ FLDAQERQ D MYDLVE W VA AQP WC D - G N VG MI G ISYFAMSQ L E AA VER P P h L K A IFP 163
Cdd:COG0412 78 ralmga LDPELLAA D LRAALD W LK AQP EV D a G R VG VV G FCFGGGLA L L AA ARG P D - L A A AVS 138
Peptidase_S9
pfam00326 Prolyl oligopeptidase family;
84-170
2.40e-04
Prolyl oligopeptidase family;
Pssm-ID: 459761 [Multi-domain]
Cd Length: 213
Bit Score: 42.60
E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997081558 84 FWVP RGY AHV IAN L RG TC G S G gt FG F L DA QERQ ---- DMY D L --- V E WVAA Q PWC D GN - VGMI G I SY FAMSQLE A AVE RP 155
Cdd:pfam00326 9 LLAD RGY VVA IAN G RG SG G Y G -- EA F H DA GKGD lgqn EFD D F iaa A E YLIE Q GYT D PD r LAIW G G SY GGYLTGA A LNQ RP 86
90
....*....|....*
gi 1997081558 156 PHL KA IFPVAVTA D L 170
Cdd:pfam00326 87 DLF KA AVAHVPVV D W 101
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
