|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
17-384 |
9.77e-59 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 195.88 E-value: 9.77e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 17 LKLFNFFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTLL-LVQFV 95
Cdd:cd17335 2 LKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLfFLSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 96 FQANTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGR----ISIVF 171
Cdd:cd17335 82 FVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKnytiAFYVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 172 SIMLLVAALFMFTLPsIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGGTKQMVGLAIF 251
Cdd:cd17335 162 AVLMLLALLLALKFP-FRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 252 FSSIFEVVIFILFDRFLKRKinVLVGCLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTP 331
Cdd:cd17335 241 VGVVSEIPFFFFSSRLIQRF--GHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPG 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2014777257 332 YRASGQAIYTLSWSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFG 384
Cdd:cd17335 319 LRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
14-369 |
1.48e-46 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 163.57 E-value: 1.48e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 14 LTSLKLFNFFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTLLL-- 91
Cdd:pfam12832 1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLfl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 92 -VQFVFQANTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIV 170
Cdd:pfam12832 81 sVLFIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLLPSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 171 FSIMLLVAAL--FMFTLPSIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGGTKQMVGL 248
Cdd:pfam12832 161 LFYLFAALMLlsLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 249 AIFFSSIFEVVIFILFDRFLKR--KINVLVGCLtivsLLFALRWLLMAEANSALEVAF-IQLLHCVTFGGYFYVGVQLTM 325
Cdd:pfam12832 241 LWALGVVAEIPLFFYAHRLLRRfgHRNLLIIAL----LLTALRWLLYAFFVENPWLVLpIQFLHAISFGLTHAAAIEYVR 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2014777257 326 LFVPTPYRASGQAIYTLSWSGISGVIGGLAGGWMFQNFGAQIMY 369
Cdd:pfam12832 317 RIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTF 360
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
14-383 |
3.62e-16 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 79.60 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 14 LTSLKLFNFFIYGT-MVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFanpFWGFWGDRAANIKRVLLIMMTGTLLLV 92
Cdd:cd06177 2 LSVMMFLQFFIWGAwLVTLGGYMGSTLGFTGAQIGAVYSTTGIAAIIMPF---FLGIIADRFFAAEKVLAVLHLIGAAAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 93 QFVFQANTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQKFGSFRLWGSLGWaltaIAAGPVIDRLG---SGRISI 169
Cdd:cd06177 79 FYAATVTDFSVFFWVMLLYSLCYMPTLALTNSIAFSNLEDPVKDFPPIRVWGTIGW----IAAGWPVGFLGweaSNLQFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 170 VFSIMLLVAALFMFTLPSIQKTTASASVNLKGLSR-----LFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGGTKQ 244
Cdd:cd06177 155 IAAGASLLLGLYSLTLPHTPPKKAGKGVSKRSLLGldafvLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDFGMIVK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 245 MVGLAIFFSSIFEVVIFILFDRFLKR---KINVLVGCLTivsllFALRWLLMAEANSALEVAFI---QLLHCVTFGGYFY 318
Cdd:cd06177 235 NPAGIMSLGQISEILFMLAIPFFLKRlgiKKVMLIGMLA-----WVLRFGLFAYGDPSPGVWMLvlsIILHGVCYDFFFV 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2014777257 319 VGVQLTMLFVPTPYRASGQAIYTLSWSGISGVIGGLAGGWMFQNFGA-------QIMYWTGTMLAIVGAIGF 383
Cdd:cd06177 310 TGYIYVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTvegtkdwQTIWLVPAIYALVLAILF 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-386 |
1.31e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.53 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 22 FFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAAniKRVLLIMMTGTLLLVQFVFqanTY 101
Cdd:cd17325 6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG--RKRLLLLGLLLLAVSTLLF---AF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 102 AMIYMTMIFFYFFQTPMFSQTNSLILTYI------EGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIML 175
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIadiappEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 176 LVAALFMFTL-----PSIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGG-TKQMVGLA 249
Cdd:cd17325 161 LLALVLALLLlpeprPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 250 IFFSSIFEVVIFILF----DRFLKRKinVLVGCLTIVSLLFalrwLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTM 325
Cdd:cd17325 241 FGAQGLASALSQPPAgklsDRIGRKP--LILIGLLLSAVAL----LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2014777257 326 LFVPTPYRASGQAIYTLSWSgISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFGWM 386
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFS-LGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
18-383 |
5.79e-14 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 72.73 E-value: 5.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 18 KLFNFFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAAniKRVLLIMMTGTLLLVQFVFQ 97
Cdd:cd17479 2 SLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYR--KRRFVILFSLLISLGTYLLY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 98 ANTYAMIYMTMIFFYFFQTPM-FSQTNSL--ILTYIEGTqQKFGSFRLWGSLGWALTAIAAGPVIDRL------GSGRIS 168
Cdd:cd17479 80 HQIFLLVLLVIIIWELLSAPLeKVADDSLyeYLDFVDAT-ERYGKLKVWSALGAAFGPCGITLLVDNLdcflppKISRIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 169 I------VFSIMLLVAALFmFTLPSIQKTTASASVNlKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGGT 242
Cdd:cd17479 159 LhfytygGFMILTFLLSFF-YPIPVPKKEEHSSKVV-KGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 243 KQMVGLAIFFSSIFEVVIFILFDRFLKRKINvlVGCLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGG-YFYVGV 321
Cdd:cd17479 237 ELHMGLSIALALLSEILMSFFGNWLLRKLGH--AGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGAlWWAVNS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2014777257 322 QLTMLFVPTPYRASGQAIYTLSWsGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGF 383
Cdd:cd17479 315 QVEFLASPGMERSLQLVLRALYY-GIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIF 375
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
17-311 |
1.45e-13 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 71.49 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 17 LKLFNFFIYGTMVIFTGFFQLYL-QDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAAnIKRVLLIMMTGTLLLV--- 92
Cdd:cd06172 4 FSLFFFLFFFIWSASFSFFPIWLtQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLG-LKKHLLWFISGLLVLFgpf 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 93 -QFVF----QANTYAMIYMTMIFFYFfqtpMFSQTNSLILTYIEGTQQK----FGSFRLWGSLGWALTAIAAGpvidRLG 163
Cdd:cd06172 83 fIFVYgpllQSNILLGAIVGGIYLGF----AFLAGCGAIESYIERVSRRfnfeYGRARMWGSLGWALAAFFAG----ILF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 164 SGRISIVFSIMLLVAALFMFTLPSIQKTT---------ASASVNLKGLSRLFLNSYFVWFILLGIMVS-IPNTAN----N 229
Cdd:cd06172 155 NINPNINFWLGSGFALILLLLLLFAKPEDsdtaaaagaNASSVSLKDVLELFRMPKFWFFILFVIGVScFYDVFDqqfpP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 230 TFMSLYILELGGTkQMVGLAIFFSSIFEVVIFILFDrFLKRKINVLVGcLTIVSLLFALRWLLMAEANSALEVAFIQLLH 309
Cdd:cd06172 235 YFTSLFATPEQGN-RVFGYLNSAQVFLEAGMMFLAP-LIVNRIGAKNG-LLLAGTIMAVRIIGSGLATSPLEISILKLLH 311
|
..
gi 2014777257 310 CV 311
Cdd:cd06172 312 AF 313
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-383 |
2.89e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.53 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 17 LKLFNFFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAaNIKRVLLIMMTGTLLLVQFVF 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 97 QANTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQK--FGSFRLWGSLGWALTAIAAGPVIDRLGSGR------IS 168
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGraLGLLQAFGSVGGILGPLLGGILASSLGFGWravfliAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 169 IVFSIMLLVAALFMFTLP---SIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGG-TKQ 244
Cdd:cd06174 160 ALALLAAILLLLVVPDPPesaRAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 245 MVGLAIFFSSIFEVVIFILFDRFLKRKINVLVgCLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLT 324
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP-LLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2014777257 325 MLFVPTPYRASGQAIYTLSWSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGF 383
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| PRK11128 |
PRK11128 |
3-phenylpropionate MFS transporter; |
22-314 |
1.26e-12 |
|
3-phenylpropionate MFS transporter;
Pssm-ID: 236856 [Multi-domain] Cd Length: 382 Bit Score: 68.77 E-value: 1.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 22 FFIYGtmvIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTLLLVQFVF--QAN 99
Cdd:PRK11128 17 FFAYG---VFLPFWSVWLKGQGYTPETIGLLLGAGLVARFLGSLLIAPRVKDPSQLIPALRLLALLTLLFAVAFWfgAHS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 100 TYAMIYMTMIFFYFFqTPMFSQTNSLILTYIEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIMLLVAA 179
Cdd:PRK11128 94 FWLLFVAIGLFNLFF-SPLVPLTDALANTWQKQIGLDYGKVRLWGSIAFVIGSALTGKLVSWFGEQAILWILTAGVASML 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 180 LFMFTLPSIQKTTAS---ASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGGTKQMVGLAIFFSSIF 256
Cdd:PRK11128 173 LGQLLRPTIMPQGESrqqESAGWPAWKALLKEPTVWRFLLCVSLLQGSHAAYYGFSAIYWQAAGYSASTIGYLWSLGVVA 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2014777257 257 EVVIFILFDRFLKR-KINVLvgcLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFG 314
Cdd:PRK11128 253 EVLIFAFSNRLFRRwSARDL---LLLSAICGVVRWGLMGSTTALPWLIVIQILHCGTFT 308
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-364 |
4.14e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 4.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 19 LFNFFIYGTMVIFTGFFqlYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANI--KRVLLIMMTGTLLLVQFVF 96
Cdd:COG2211 20 LGLNLAFGLLSAYLLYF--YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 97 QANT--------YAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQK---FGSFRLWGSLGWALTAIAAGPVIDRLGSG 165
Cdd:COG2211 98 LFTApdlsptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERtrlSSWRFAFAGLGGLLASVLPPPLVAAFGGD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 166 RISIVFSIMLLVAALFM-------FTLPSIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILE 238
Cdd:COG2211 178 AALGYRLTALIFAVLGLlaflltfFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 239 -LGGTKQMVGLAIFFSSIFEVVIFILFDRFLKR--KINVLVGCLTIVSLLFAlrWLLMAEANSALEVAFIQLLHCVTFGG 315
Cdd:COG2211 258 vLGLSAALVGLLLALYFLAALLGAPLWPRLAKRfgKKKAFIIGLLLAALGLL--LLFFLGPGNLWLLLVLAALAGIGLGA 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2014777257 316 YFYVGVQLTMLFVPTPYRASGQ-------AIYTLSwSGISGVIGGLAGGWMFQNFG 364
Cdd:COG2211 336 ILVLPWAMLADVVDYDEWKTGRrreglyfGIFTFA-IKLGQALAGALAGLLLALFG 390
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-386 |
9.45e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 66.10 E-value: 9.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 21 NFFIYGTMVIFTGFFQLYL-QDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTLLLVQFVFQAN 99
Cdd:cd17329 8 SFLNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 100 TY---AMIYMTMIFFYFFQTPMfsqtNSLILTYIEGTQQK--FGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIM 174
Cdd:cd17329 88 PWlfaIALVLTGFGGGLFEPAS----EAMIADVTTPENRTraFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 175 LLVAALFMFTLPSIQKTTASASV--NLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILE-LGGTKQMVGLAIF 251
Cdd:cd17329 164 LLAALVLLFLLPETRPKRRAAEKteILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEiLGLGESLLGLLLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 252 FSSIFEVVIFILFDRFLKRK--INVLVGCLTIVSLLFALRWLLMAEANSALEVAFIqllhcvTFGGYFYVGVQLTMLF-- 327
Cdd:cd17329 244 LNALLIVLLQFPVARLVERFrlRKILMIGILLFAIGFAVLAFANTLAVLILAMIVL------TLGEMLVFPAVQTLVAal 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2014777257 328 VPTPYRASGQAIYTLSWsGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFGWM 386
Cdd:cd17329 318 APPDKRGSYMGFYALAW-GLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
21-381 |
1.40e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 65.26 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 21 NFFIYGTMVIFTGFFQLYL-QDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTLLLVQFVFQAN 99
Cdd:cd17471 5 TLLTGLAGAFVLPYLSLFLtEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 100 TYAMIYMTMIFFYFFQTPMFSQTNSLILTYIE---GTQQKF--GSFRLWGSLGWALTAIAAGPVIDRLG-SGRISIVFSI 173
Cdd:cd17471 85 NYWVLLLVGVVLLSLGAAAFPQLFALAREYADrssGRDATLfnSVLRAAFSLAWVIGPPLAFLLLDVLGfTGLFLLAALL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 174 MLLVAALFMFTLPSIQKTTASASVNLKGLSRLfLNSYFVWFILLGIMVSIPNTANNTFMSLYIL-ELGGTKQMVGLAIFF 252
Cdd:cd17471 165 YLVVALLVLFLLPSVKPPAQKATPASSLVKAP-VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTnELGGSESWVGLLFGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 253 SSIFEVVIFILFDRFLKR--KINVLVGCLTIVSLLFALRWLlmaeANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPT 330
Cdd:cd17471 244 AAALEIPIMLLAGLLAKRfgKRRLLLAGFLAGVLFYLGLAL----ATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPG 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2014777257 331 -PYRASgqAIYTlSWSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAI 381
Cdd:cd17471 320 qPGLAT--TLYS-NASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-352 |
1.75e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 65.13 E-value: 1.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 22 FFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANiKRVLLIMMTGTLLLVQFVFQANTY 101
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR-RRVLLIGLLLFALGLLLLLFASSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 102 AMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQKF--GSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIMLLVAA 179
Cdd:pfam07690 86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRalGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 180 LFMF-----TLPSIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGGTKQMVGLAIFFSS 254
Cdd:pfam07690 166 VLLLlprppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 255 IFEVVIFILFDRFLKR-KINVLVGCLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTPYR 333
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
330
....*....|....*....
gi 2014777257 334 ASGQAIYTLSWSgISGVIG 352
Cdd:pfam07690 326 GTASGLYNTAGS-LGGALG 343
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
15-383 |
1.09e-10 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 62.87 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 15 TSLKLF-----NFFIYGTMVIFTGffqLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTL 89
Cdd:pfam03825 3 TKLRLKvmmflQFFIWGAWLVTLG---SYMFVTGFDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 90 LLVQFVFQANTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLG----SG 165
Cdd:pfam03825 80 ITLFMAAQVTTFEAFFLVILVNSLAYMPTLALTNSIAFANLQDPVTDFPPIRVWGTIGWIMASWPFVMWVVSLAgfelSH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 166 RISIVFSIMLLVAALFMFTLPSI-QKTTASASVN-LKGLS--RLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGG 241
Cdd:pfam03825 160 MQLLIAAGLSALLVLFALTLPHTpAKQKANQSWTtLLGLDafALLKNKRMAVFFIFSFLLGAELQIYNVFANTFLTSFDK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 242 TKQMVGLAIFFSSIFEVVIFIL-FDRFLKR---KINVLVGCLTivsllFALRWLLMAEANSALEVAFIQLL-----HCVT 312
Cdd:pfam03825 240 FIVKHASIIMSLGQISEILFMLtLPFFLKRfgiKNVMLIGIVA-----WALRFAFFAYGADPTPFGTALLLlsmivHGVA 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2014777257 313 FGGYFYVGVQLTMLFVPTPYRASGQAIYTLSWSGISGVIGGLAGGWMFQNFGAQ-IMYWTGTMLAIVGAIGF 383
Cdd:pfam03825 315 YDFFNITGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDgITDWQTVWLVFAGMALV 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-350 |
1.72e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.91 E-value: 1.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 19 LFNFFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRaANIKRVLLIMMTGTLLLVQFVFQA 98
Cdd:COG2814 17 LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 99 NTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQK--FGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFS-IML 175
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGraLGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAvLAL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 176 LVAALFMFTLPSIQKTTASASvnLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILE-LGGTKQMVGLAIFFSS 254
Cdd:COG2814 176 LALLLLLRLLPESRPAARARL--RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 255 IFEVVIFILFDRFLKRKINVLVgcLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTPYRA 334
Cdd:COG2814 254 LGGVLGALLAGRLADRFGRRRL--LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARG 331
|
330
....*....|....*.
gi 2014777257 335 SGQAIYTLSWSGISGV 350
Cdd:COG2814 332 RASGLYNSAFFLGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-392 |
7.04e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.27 E-value: 7.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 19 LFNFFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRaANIKRVLLIMMTGTLLLVQFVFQA 98
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR-FGRRRVLAIGLLLWGLATLLFGFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 99 NTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQ--KFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIMLL 176
Cdd:COG2271 96 TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERgrALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 177 VAALFMftlpsiqkttasasvnlkglsrlflnsyFVWFILLGIMVSIPNTANNTFMSLYILELGG-TKQMVGLAIFFSSI 255
Cdd:COG2271 176 LLALLR----------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 256 FEVVIFILF----DRFLKRKINVLVGCLtivsLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTP 331
Cdd:COG2271 228 AGIVGSLLGgwlsDRLGRRRKLVLAIGL----LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2014777257 332 YRASGQAIyTLSWSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFGWMWYNLRK 392
Cdd:COG2271 304 ARGTASGL-VNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-392 |
1.06e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.89 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 23 FIYGTMVIFTGFFQLYL---------QDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRaANIKRVLLIMMTGTLLLVQ 93
Cdd:COG2223 7 LLLATLAFFLAFGVWYLwsvlapplaEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDR-FGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 94 FVFQANTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQKF--GSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVF 171
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLalGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 172 SIMLLVAA----LFMFTLPSIQKTTASASvnLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGGTKQ--- 244
Cdd:COG2223 166 GILLLVVAvlawLFLRDPPAGAAAAAKAS--LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAata 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 245 --MVGLAIFFSSIFEVVIFILFDRFLKRKINVLVGCLTIVSLLFalrwLLMAEANSALEVAFIQLLhCVTFGGYFYVGVQ 322
Cdd:COG2223 244 glLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL----LALALGSLWLFLVLFLLL-GLALGGGNGAVFA 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2014777257 323 LTMLFVPTPYRASGQAIYTLSWsGISGVIGGLAGGWMFQNFGA-QIMYWtgtMLAIVGAIGFGWMWYNLRK 392
Cdd:COG2223 319 LVPDIFPTKNAGAVYGLVGAAG-GLGGFLGPLLFGALLDATGSyTAAFL---VFAVLALVALVLTLLLYRR 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-381 |
3.49e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.95 E-value: 3.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 37 LYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAaNIKRVLLIMMTGTLLLVQFVFQANTYAMIyMTMIFFYFFQT 116
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRK-PRRYLLPLGPLLTGLGLSLLGFAPNYWLL-LLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 117 PMFSQTNSLILTYIEGTQQKFGS--FRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIMLLVAALFMFTLPSIQKTTAS 194
Cdd:cd17478 99 AAFHPEGARLASQAAGGRRGLAMsiFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 195 ASVNLKGLSRLFLNSYFVWFILLGIMV--SIPNTANNTFMSLYILELGGTKQMVGLAIF---FSSIFEVVIF-ILFDRFL 268
Cdd:cd17478 179 KAAAKSSARSTLKGVWRALLLLLIIVFlrSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSlflFAGAIGTLIGgPLSDRFG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 269 KRKinVLVGCLTIVSLLFalrwLLMAEANSALEVAFIQLLhCVTFGGYFYVGVQLTMLFVPTPYRASGQAIYTLSWSGis 348
Cdd:cd17478 259 RRR--VIIASLLLAAPFL----LLFLLTPGIWSYILLVLA-GFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGL-- 329
|
330 340 350
....*....|....*....|....*....|...
gi 2014777257 349 GVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAI 381
Cdd:cd17478 330 GGIGAPVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-385 |
3.81e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 3.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 19 LFNFFIYGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANiKRVLLIMMtgtlllvqFVFQA 98
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGR-KRLLLIGL--------LIFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 99 NTYAMIYMTMIFFYF-------FQTPMFSQTNSLILTYIEGTQQK---FGSFRLWGSLGWALTAIAAGPVIDRLGSGRIS 168
Cdd:cd17489 74 ATLLYLLATSVALLLvlrlihgIGWGAFTTAAATLVADIIPPSRRgegIGYYGLATTLAMALGPALGLFLYQHLGFAVLF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 169 IVFSIMLLVAALFMFTLPsIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMV-SIPNTANNTFMSLYILELGGTKqmvg 247
Cdd:cd17489 154 IVAAVLALLALLLVFLVK-DPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLaSIAYGAISTFLPLYAAERGISN---- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 248 lAIFFSSIFEVVIFI-------LFDRflKRKINVLVGCLtivsLLFALRWLLMAEANSALEVAFIQLLHCVTFgGYFYVG 320
Cdd:cd17489 229 -AGLFFTVYAIALLLsrpfsgkLSDR--KGPKTVIIPGL----LLLALGLLLLSFAGSPWMLLLAAVLYGLGF-GLLFPA 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2014777257 321 VQLTMLFVPTPY-RASGQAIYTLSWSgISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFGW 385
Cdd:cd17489 301 LQALAVDLVPPHrRGAANGTFFIFFD-LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| lacY |
PRK09528 |
galactoside permease; Reviewed |
1-309 |
4.73e-09 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 57.98 E-value: 4.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 1 MTYLRNmdnaqPSLTSLKLFNFFIYGTMVIFTGFFQLYLQD-IGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAAnIKR 79
Cdd:PRK09528 4 MYYLKN-----PNYWIFSLFFFFFFFIWSSWFSFFPIWLHDiNGLSGTDTGIIFSANSLFALLFQPLYGLISDKLG-LKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 80 VLLIMMTGTLLLV----QFVFQANTYAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQQK----FGSFRLWGSLGWALT 151
Cdd:PRK09528 78 HLLWIISGLLVLFgpffIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRsgfeYGRARMWGSLGWALC 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 152 AIAAGPV--IDRLGSGRISIVFSIMLLVaaLFMFTLPSIQKTT--------ASASVNLKGLSRLFLNSYFVWFILLGIMV 221
Cdd:PRK09528 158 AFIAGILfnINPQINFWLGSGSALILLV--LLFFAKPDAPSTAkvanalgaNASAVSLKDALALLKLPKFWFLVLYVIGV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 222 SIPNTA-----NNTFMSLYILELGGTkQMVGLAIFFSSIFEVVIfILFDRFLKRKINVLVGcLTIVSLLFALRWLLMAEA 296
Cdd:PRK09528 236 ACFYDVfdqqfPNFFASFFATPEQGT-RVFGYLNSFQVFLEALI-MFFAPFIINRIGAKNA-LLLAGTIMAVRIIGSGFA 312
|
330
....*....|...
gi 2014777257 297 NSALEVAFIQLLH 309
Cdd:PRK09528 313 TGPLEVSILKLLH 325
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
229-394 |
1.70e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.51 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 229 NTFMSLYILELGGTKQMVGLAIFFSSIFEVVIFILF----DRFLKRKInVLVGcltivSLLFALRWLLMAEANSALEVAF 304
Cdd:cd17489 16 LPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAgrllDRFGRKRL-LLIG-----LLIFALATLLYLLATSVALLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 305 IQLLHCVTFGGYFYVGVQLTMLFVPTPYRASGQAIYTLSwSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFG 384
Cdd:cd17489 90 LRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLA-TTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF 168
|
170
....*....|
gi 2014777257 385 WMWYNLRKHG 394
Cdd:cd17489 169 LVKDPPPVAA 178
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-195 |
3.58e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.72 E-value: 3.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 22 FFIYGTMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTLLLVQFVFQANT 100
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 101 YAMIYMTMIFFYFFQTPMFSQTNSLILTYIEGTQ--QKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRIS-IVFSIMLLV 177
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNagAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALV 374
|
170
....*....|....*...
gi 2014777257 178 AALFMFTLPSIQKTTASA 195
Cdd:COG2223 375 ALVLTLLLYRRPRRAAAA 392
|
|
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
19-185 |
4.03e-06 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 48.61 E-value: 4.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 19 LFNFFIYGTMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAAnIKRVLLIMMTGTLLLVQ---- 93
Cdd:pfam01306 14 LFFFFYFFIMSAYFPFFPIWLHDVnHLSKTDTGIVFSCISLFSILFQPLFGLISDKLG-LRKHLLWCITGLLVLFApffi 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 94 FVF----QANTYAMIYMTMIFFYFfqtpMFSQTNSLILTYIEGTQQ----KFGSFRLWGSLGWALTAIAAGPvidrLGSG 165
Cdd:pfam01306 93 YVFgpllQSNILVGAIVGGVYLGF----VFSAGAGAIEAYIEKVSRrsnfEYGKARMFGCVGWALCASIAGI----LFSI 164
|
170 180
....*....|....*....|
gi 2014777257 166 RISIVFSIMLLVAALFMFTL 185
Cdd:pfam01306 165 DPQIVFWLGSGFALILALLL 184
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-381 |
6.66e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.93 E-value: 6.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 40 QDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAaNIKRVLLIMMTGTLLLVQFVFQANTYAMIYMTMIFFYFFQTPMF 119
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRI-ERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 120 SQTNSLILTYIEGTQQKFGsfrlwgsLGWALTAIAAGPVIDRLGSGRISIVFS----------IMLLVAALFMFTLPSIQ 189
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRA-------IGLVFSGLTLGLVLGRPLGGLLGQLLGwraaflaiavLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 190 KTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILEL-GGTKQMVGLAIFFSSIFEVVIFILFDRFL 268
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 269 KRkinVLVGCLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTPYRASGQAIYTLSWSgIS 348
Cdd:cd17324 259 DR---GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYN-LG 334
|
330 340 350
....*....|....*....|....*....|...
gi 2014777257 349 GVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAI 381
Cdd:cd17324 335 GALGAALGGLVLDHGGWAGVGWVGAALLLLALL 367
|
|
| mfs |
NF037955 |
MFS transporter; |
137-314 |
1.04e-05 |
|
MFS transporter;
Pssm-ID: 411561 [Multi-domain] Cd Length: 366 Bit Score: 47.34 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 137 FGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIML-LVAALFMFTLPsiqKTTASASVNLKGLSRLFLNSYFVWFI 215
Cdd:NF037955 125 YARIRMSGSVAFLAANLAGGALLGALGERVAVPLLLTGLaLVAALVALASR---VRAAAAPPRPREAGRPRLPRVLWLAI 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 216 LLGIMVSIPNTANNTFMSLYILELGGTKQMVGLAIFFSSIFEVVIFILFDRFLKRKiNVLVGCLTIVSLLFALRWLLMAE 295
Cdd:NF037955 202 AAGAAIQASHAAIYAFGSIHWRAHGISTAWIGALWAIGVVAEIVLFALLGRLPARW-RTPFRLLGLGAAAALVRAIGMAL 280
|
170 180
....*....|....*....|
gi 2014777257 296 ANSALE-VAFIQLLHCVTFG 314
Cdd:NF037955 281 LGGTLAaVVPLQALHGLTFG 300
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
27-320 |
2.75e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 46.15 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 27 TMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGF--------WGDRAANIKRVLLIMMTGTLLL--VQFV 95
Cdd:pfam13347 12 KYAGLATYLLYFYTDVlGLSAAAVGLVLLVARLVDAFTDPIVGHiidrtrtrWGRRRPWLLLSAIILAVSFILLftPPEL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 96 FQANTYAMIYMTMI----FFYFFQTPMFSQTNSLILTYIEGTqqKFGSFRLWGS-LGWALTAIAAGPVIDRLGSGRIS-- 168
Cdd:pfam13347 92 GRAPLFIWLLATYIllriAYTFFEIPYWSLGPELTRDYDERT--SLTSYRSFFSvGGGLLAAALAFPLVLILGGTGLErk 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 169 ------IVFSIMLLVAALFMFT-------LPSIQKTTASASVNL-KGLSRLFLNSYFVWFILLGIMVSIPNTANNT---F 231
Cdd:pfam13347 170 gyrifaLIGAVLMLLGVIITAAgtkervsMRSKEDTGQKEAGSLlDMLKEVFRNRAFLILLASFLLAALAMGVLNGlllY 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 232 MSLYILELGGTKQMVGLAIFFSSIFEVVIFILF-DRFLKRKINVLVGCLTIVSLLFAlrwlLMAEANSALEVAFIQLLHC 310
Cdd:pfam13347 250 YFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLaKRIGKKNTYILGALITIAGFALA----LLLGPNNTLLFLVLYIIIG 325
|
330
....*....|
gi 2014777257 311 VTFGGYFYVG 320
Cdd:pfam13347 326 FGYGSSFFLP 335
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
23-305 |
3.79e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.67 E-value: 3.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 23 FIYGTMVIFTGFFqlYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKR-----------------VLLIMM 85
Cdd:cd17332 13 LIFQIVSTYLLFF--YTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGrfrpwllwgaiplallfVLLFTT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 86 TGTLLLVQFVFqantYAMIYMTMIFFY-FFQTPMFSQTNSLILTYIEGTqqKFGSFR-LWGSLGWALTAIAAGPVIDRLG 163
Cdd:cd17332 91 PDGSGTGKLIY----ALITYILLDLLYtLVNIPYTALIPELTDDPEERT--SLTSWRmFFATIGGLLVTVLPPPLVAYFG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 164 SGR-----------ISIVFSIMLLVAALFMFTLPSIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFM 232
Cdd:cd17332 165 GGNasrgyfltaliIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVL 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2014777257 233 SLYILELGGTKQ---MVGLAIFFSSIFEVVIFILFDRFLKRKINVLVGCLtiVSLLFALRWLLMAEANSALEVAFI 305
Cdd:cd17332 245 VYYFKYVLGGRAelvLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLL--LAILGLLLLFFLPPGNLVLILVLA 318
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
211-387 |
1.89e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 211 FVWFILLGIMVSIPNTANNTFMSLYILELGGTKQMVGLAIFFSSIFEVVIFILF----DRFLKRKInvlvgcLTIVSLLF 286
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAgrlaDRFGRRRV------LLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 287 ALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTPYRASGQAIYTLSWsGISGVIGGLAGGWMFQNFGAQ 366
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGL-GLGPALGPLLGGLLADLFGWR 164
|
170 180
....*....|....*....|.
gi 2014777257 367 IMYWTGTMLAIVGAIGFGWMW 387
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLL 185
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-392 |
4.59e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 4.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 22 FFIYGTMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAaNIKRVLLIMMTGTLLLVQFVFQANT 100
Cdd:COG0738 17 FFLWGFATALWGPLIPALKDAfGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF-GYKRGLLLGLLLMALGLLLFALAPS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 101 YAMIYMTMIFFYFFQTPMFSQTNSLILT-YIEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIM----- 174
Cdd:COG0738 96 YPLLLLALFLLGLGLGLLDVAANPYVAAlGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILavlll 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 175 LLVAALFMFTLPSIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILELGG-TKQMVGLAIFFS 253
Cdd:COG0738 176 LLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGlSEATAALGLSLF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 254 SIFEVVIFILFDRFLKR--KINVLVGCLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTmlfvptP 331
Cdd:COG0738 256 WGGMTIGRFLGGFLLKRfgPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL------G 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2014777257 332 YRASGQAIYTLSWSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFGWMWYNLRK 392
Cdd:COG0738 330 KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
152-381 |
5.38e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.78 E-value: 5.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 152 AIAAGPVIDRLGSGR----ISIVFSIMLLVAALFMFTLPSIQKTTASASVNLKGLSRLflnsyfVWFILLGIMVS-IPNT 226
Cdd:cd17477 132 GFALGPLLLALVGTAgalpFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRI------APLALLGAFVAgFLEG 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 227 ANNTFMSLYILELGGTKQMVGLAIFFSS----IFEVVIFILFDRFLKRKinVLVGCLTIVSLLFALRWLLMAEANSALEV 302
Cdd:cd17477 206 AFYSLLPLYGLRLGLSVAQAALLLAAFVlgglLLQWPLGWLADRFDRRR--VLLGCALLGALAALLLPLVPGLPLALLVL 283
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2014777257 303 AFiqlLHCVTFGGYFYVGVQLTMLFVPTPYRASGQAIYTLSWsGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAI 381
Cdd:cd17477 284 LF---LWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLY-GLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
169-383 |
6.85e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 6.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 169 IVFSIMLLVAALFMFTLPSIQKTTASASVNLKGLSRLFLNSYFVWFILLGIMVSIPNtANNTFMSLYILELGGTKQMVGL 248
Cdd:cd17370 160 LLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGN-FSFAFLILRAQELGLSAALIPL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 249 --AIF--FSSIFEVVIFILFDRFLKRKINVL-VGCLTIVSLLFALRWLLMAeansaLEVAFIqllhcvtFGGyFYVGVQL 323
Cdd:cd17370 239 lyALFnlVYALAAYPAGRLSDRIGRKKLLILgYLSLALAYLGFALGSSLWL-----LLLGFI-------LWG-LYMGAQE 305
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2014777257 324 TML------FVPTPYRASGQAIYTLSWsGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGF 383
Cdd:cd17370 306 SIEraavadLVPAELRGTAYGLFNTVV-GIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
37-386 |
8.07e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 37 LYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAaNIKRVLLIMMTG-----TLLLVQFVFQANTYAMIYMTMIFF 111
Cdd:cd06173 24 WLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRF-DRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 112 YFFQTPMFSQTNSLI--LTYIEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIMLLVAALFMFTLPSIQ 189
Cdd:cd06173 103 GIASAFFGPARQALLpeLVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 190 KTTASASVNLK------GLSRLFLNSYFVWFILLGIMVSIPNTANNTFMSLYILE-LGGTKQMVGLAIFFSSIFEVVIFI 262
Cdd:cd06173 183 PAAPGESSSLLlrdlreGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 263 LFDRFLKRKINVLVgcLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTPYRASGQAIYTL 342
Cdd:cd06173 263 LLGRLSKRRRRGRL--LLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2014777257 343 SwSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAIGFGWM 386
Cdd:cd06173 341 L-NSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-127 |
1.21e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 12 PSLTSLKLFNFFIYGTMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGFWGDRaANIKRVLLIMMTGTLL 90
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLLLAL 285
|
90 100 110
....*....|....*....|....*....|....*..
gi 2014777257 91 LVQFVFQANTYAMIYMTMIFFYFFQTPMFSQTNSLIL 127
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
17-114 |
1.88e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.31 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 17 LKLFNFFIYGTMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKR--VLLIMMT-GTLLLV 92
Cdd:cd17341 210 LSLLYGVTFGSFVGFSNVLPTYFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRlwWLFIVMTiGAALLS 289
|
90 100
....*....|....*....|..
gi 2014777257 93 QFVFQANTYAMIYMTMIFFYFF 114
Cdd:cd17341 290 LSLPTSGTNLVLFLALFVALGL 311
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
25-381 |
2.87e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 25 YGTMVIFTGFFQLYLQDIGMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAAnIKRVLLIMMTGTLLLVQFVFQANTYAMI 104
Cdd:cd17330 12 FGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYG-RKPVLLLSLAGSAVSYVLLGLSRNLWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 105 YMTMIFfyffqTPMFSQTNSLILTYI------EGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFSIMLLVA 178
Cdd:cd17330 91 FLARFL-----DGLTGGNVSVAQAYIaditdeEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 179 ALFMFTLpsiqkttasasvnLKGLSRLFLNSYFVWFILLGIMVSIPNTANNTFmslyilelGGTKQMVGLAIFFSSIFEV 258
Cdd:cd17330 166 LVLVLFF-------------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRF--------GFSPSQIGLLLALVGIAGI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 259 VIFILFDRFLKRKINVLVgCLTIVSLLFALRWLLMAEANsalevaFIQLLHCVTFGGYFYVGVQLTMLF------VPTPY 332
Cdd:cd17330 225 LAQLLLIPRLAKRLGERK-LLRLGLLLAIIGLLLLPFAS------SVPLLVLAAAILAFGTGIVFPALSallsksVPSKE 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2014777257 333 RASGQAIYTlSWSGISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIVGAI 381
Cdd:cd17330 298 QGKAQGIIQ-SLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
263-378 |
6.72e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.49 E-value: 6.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 263 LFDRFLKRKinVLVGCLtivsLLFALRWLLMAEANSALEVAFIQLLHCVTFGGYFYVGVQLTMLFVPTPYRASGQAIYTL 342
Cdd:TIGR00895 75 LADRIGRRR--VLLWSI----LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148
|
90 100 110
....*....|....*....|....*....|....*.
gi 2014777257 343 SWSgISGVIGGLAGGWMFQNFGAQIMYWTGTMLAIV 378
Cdd:TIGR00895 149 GYP-IGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL 183
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
166-383 |
6.74e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.28 E-value: 6.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 166 RISIVFSIMLLVAALFM-FTL---PSIQKTTASASVNLKGLSRLFLNSYfvWFILLGIMVSIPNTANNTFMSLYIL---- 237
Cdd:cd17369 179 RIPFLLSAVLVAVGLYIrLRLeetPVFRRAKEAGQVVRAPLVEVLRRHW--RALLLAIGLRLAENVLFYLFTTFALsyat 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 238 -ELGGTKQMVGLAIFFSSIFEVVIFILF----DRFlKRKINVLVGCLTIVSLLFALRWLLMAEANSALEVAFIQLLHCVT 312
Cdd:cd17369 257 qTLGVDRSTVLLAVLIASVVAAITIPLFgwlsDRV-GRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLH 335
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2014777257 313 FGGYFYVGVQLTMLFvPTPYRASGQAI-YTLSwSGISGVIGGLAGGWMFQNFGAqiMYWTGTMLAIVGAIGF 383
Cdd:cd17369 336 GMMYGPQAAFLAELF-PTRVRYTGASLgYQLG-AILGGGFAPLIATALVAATGS--WWPVALYLAALAVISL 403
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
17-185 |
7.60e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.41 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 17 LKLFNFFIYGTMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKR-----VLLIMMTGTLL 90
Cdd:cd17312 188 LSLAYAFVYIVRYACLDWGPLYLYEVkGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRapiavIYMLLMTLSLA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 91 LVQFVFQANTYAMIYMTMI-FFYFFQTPMFSQTNSLILTYIEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISI 169
Cdd:cd17312 268 LFWFFPHNKLLSIVLLFLIgFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFY 347
|
170
....*....|....*.
gi 2014777257 170 VFSIMLLVAALFMFTL 185
Cdd:cd17312 348 FLISAALLSVLLLLSL 363
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-185 |
9.38e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 37.94 E-value: 9.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 19 LFNFFIYGTMVIFTGFFQLYLQDI-GMSKIEIGSLMAIAPFVSIFANPFWGFWGDRAANIKRVLLIMMTGTLLLVQFVFQ 97
Cdd:cd17319 186 LGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLA 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2014777257 98 ANTY----AMIYMTM-IFFYFFQTPMFSQTNSLILTYiEGTQQKFGSFRLWGSLGWALTAIAAGPVIDRLGSGRISIVFS 172
Cdd:cd17319 266 YLTTspvvAVILLSLaGFGIGAASPVFWSLPADLLPG-EAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFL 344
|
170
....*....|....
gi 2014777257 173 -IMLLVAALFMFTL 185
Cdd:cd17319 345 aAVALLAALLVLLL 358
|
|
| |
