NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2021943934|ref|WP_209043584|]
View 

DNA-directed RNA polymerase subunit beta [Prochlorococcus marinus]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11478603)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
15-1067 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


:

Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2031.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFL-------EKGLIEELQNFSPISDYTGKLELHFIgeDYRLKRPRHDVEEAKRRDATFASQMYVTC 87
Cdd:PRK00405    24 LPNLLEIQLDSFDWFLqldvppeDEGLEEVFRSIFPIEDFNGNLSLEFV--SYELGEPKYDVEECKERGLTYSAPLRVKL 101
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   88 RLINKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDK--NGRRTYNASVIPNRGAWLKFET 165
Cdd:PRK00405   102 RLINKETGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHDKDKtsSGKLLYSARIIPYRGSWLEFEF 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  166 DKNNLLYVRVDKTRKINAHVLMRAMGLSDNDVVDKLRHPEFYQSSIDSAND----------------------------- 216
Cdd:PRK00405   182 DPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFGKEIEVPVEyllgkvlaedivdeetgevlaeandeite 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  217 -------------EGINSEDQALLELYKKLRPGEPPSVSGGQQLLHSRFFDPKRYDLGRVGRYKINKKLRLTVPDEVRTL 283
Cdd:PRK00405   262 eldgpyirntlekDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVL 341
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  284 THEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPL 363
Cdd:PRK00405   342 TKEDIIATIKYLINLRNGKG--EVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPV 419
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  364 VAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATH 443
Cdd:PRK00405   420 VAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATY 499
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  444 ARVNEYGFIETPFWEVNNGRVNKEgnPVYLSADLEDECRVAPGDVATDKDGNILANLIPVRYRQDFEKVPPHQVDYVQLS 523
Cdd:PRK00405   500 ARVNEYGFIETPYRKVVDGKVTDE--IVYLTADEEDNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVS 577
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  524 PVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLESQVARDSGMVPITKVNGIVSYVDANEIVVK- 602
Cdd:PRK00405   578 PKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRv 657
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  603 -----DTEGNEHFHyLQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAIL 677
Cdd:PRK00405   658 eeldpGEDGVDIYN-LIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAIL 736
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  678 VSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPP 757
Cdd:PRK00405   737 ISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTP 816
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  758 EEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTR-EQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGII 836
Cdd:PRK00405   817 EEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTRiEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVV 896
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  837 SRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDemyGAekSHQTVQAFLEEAskq 916
Cdd:PRK00405   897 SRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKFATPVFD---GA--KEEEIKELLEEA--- 968
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  917 pgkawvyNPDDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEV 996
Cdd:PRK00405   969 -------GLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEV 1041
                         1050      1060      1070      1080      1090      1100      1110
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2021943934  997 WALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIGVYTDEGKE 1067
Cdd:PRK00405  1042 WALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDEDGNE 1112
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
15-1067 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2031.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFL-------EKGLIEELQNFSPISDYTGKLELHFIgeDYRLKRPRHDVEEAKRRDATFASQMYVTC 87
Cdd:PRK00405    24 LPNLLEIQLDSFDWFLqldvppeDEGLEEVFRSIFPIEDFNGNLSLEFV--SYELGEPKYDVEECKERGLTYSAPLRVKL 101
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   88 RLINKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDK--NGRRTYNASVIPNRGAWLKFET 165
Cdd:PRK00405   102 RLINKETGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHDKDKtsSGKLLYSARIIPYRGSWLEFEF 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  166 DKNNLLYVRVDKTRKINAHVLMRAMGLSDNDVVDKLRHPEFYQSSIDSAND----------------------------- 216
Cdd:PRK00405   182 DPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFGKEIEVPVEyllgkvlaedivdeetgevlaeandeite 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  217 -------------EGINSEDQALLELYKKLRPGEPPSVSGGQQLLHSRFFDPKRYDLGRVGRYKINKKLRLTVPDEVRTL 283
Cdd:PRK00405   262 eldgpyirntlekDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVL 341
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  284 THEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPL 363
Cdd:PRK00405   342 TKEDIIATIKYLINLRNGKG--EVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPV 419
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  364 VAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATH 443
Cdd:PRK00405   420 VAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATY 499
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  444 ARVNEYGFIETPFWEVNNGRVNKEgnPVYLSADLEDECRVAPGDVATDKDGNILANLIPVRYRQDFEKVPPHQVDYVQLS 523
Cdd:PRK00405   500 ARVNEYGFIETPYRKVVDGKVTDE--IVYLTADEEDNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVS 577
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  524 PVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLESQVARDSGMVPITKVNGIVSYVDANEIVVK- 602
Cdd:PRK00405   578 PKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRv 657
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  603 -----DTEGNEHFHyLQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAIL 677
Cdd:PRK00405   658 eeldpGEDGVDIYN-LIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAIL 736
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  678 VSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPP 757
Cdd:PRK00405   737 ISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTP 816
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  758 EEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTR-EQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGII 836
Cdd:PRK00405   817 EEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTRiEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVV 896
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  837 SRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDemyGAekSHQTVQAFLEEAskq 916
Cdd:PRK00405   897 SRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKFATPVFD---GA--KEEEIKELLEEA--- 968
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  917 pgkawvyNPDDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEV 996
Cdd:PRK00405   969 -------GLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEV 1041
                         1050      1060      1070      1080      1090      1100      1110
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2021943934  997 WALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIGVYTDEGKE 1067
Cdd:PRK00405  1042 WALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDEDGNE 1112
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
15-1065 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1849.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFigEDYRLKRPRHDVEEAKRRDATFASQMYVTCRLINKET 94
Cdd:COG0085     13 LPNLLEIQLDSFNWFLEEGLQEIFDEISPIEDFTGNLSLEF--GDYRLGEPKYTPEECKERDLTYAAPLYVKVRLVNKET 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   95 GEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDKNGRRTYNASVIPNRGAWLKFETDKNNLLYVR 174
Cdd:COG0085     91 GEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDKSGKDLYSAKVIPSRGAWLEFETDKDGTIYVR 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  175 VDKTRKINAHVLMRAMGL-SDNDVVDKLRHPEFYQSSIDSANDEGINSEDQALLELYKKLRPGEPPSVSGGQQLLHSRFF 253
Cdd:COG0085    171 IDRKRKIPVTVLLRALGLeTDEEILEAFGDDPIQEYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFF 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  254 DPKRYDLGRVGRYKINKKLRLTVPDEVRTLTHEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGL 333
Cdd:COG0085    251 DPKRYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGER--EPDDIDHLGNRRVRLVGELLQNQFRVGL 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  334 NRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVR 413
Cdd:COG0085    329 SRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVR 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  414 DIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWEVNNGRVNKEGnpVYLSADLEDECRVAPGDVATDKD 493
Cdd:COG0085    409 DVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEI--EYLTADEEENYYIAQANAPLDED 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  494 GNILANLIPVRYRQDFEKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVgtgles 573
Cdd:COG0085    487 GNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPLL------ 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  574 qvardsgmvpitkvngivsyvdaneivvkdtegnehfHY-LQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGG 652
Cdd:COG0085    561 -------------------------------------HYpLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNG 603
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  653 EIALGQNVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIR 732
Cdd:COG0085    604 ELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIR 683
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  733 IGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREQGDELPPGANMVVRV 812
Cdd:COG0085    684 IGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREEGDELPPGVNKLVRV 763
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  813 YVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVP 892
Cdd:COG0085    764 YVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPV 843
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  893 FDEMYGAEkshqtVQAFLEEAskqpgkawvyNPDDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPY 972
Cdd:COG0085    844 FDGAPEEE-----IRELLEKA----------GLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPY 908
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  973 SLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQ 1052
Cdd:COG0085    909 SLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQ 988
                         1050
                   ....*....|...
gi 2021943934 1053 SLGLDIGVYTDEG 1065
Cdd:COG0085    989 SLGLDVEVLSEDG 1001
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
10-1058 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1816.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   10 KTATYLPDLVEVQRASFKWFL----------EKGLIEELQNFSPISDYTGKLELHFIgeDYRLKRPRHDVEEAKRRDATF 79
Cdd:TIGR02013   12 PEVLEVPNLLEIQLDSYDWFLqqdtppekrkEEGLEEVFKSIFPIEDYTGNIELEYL--SYRLGEPKYSVEECKERGLTY 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   80 ASQMYVTCRLINKE---TGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQD--KNGRRTYNASVI 154
Cdd:TIGR02013   90 SAPLKVKLRLINKEedgTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKDttKSGKVLFSARII 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  155 PNRGAWLKFETDKNNLLYVRVDKTRKINAHVLMRAMGLSDNDV-VDKLRHPEFYQSSIDSandEGINSEDQALLELYKKL 233
Cdd:TIGR02013  170 PYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLiLNRLGSGEYIRNTLRK---DPTNSEEEALVEIYRKL 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  234 RPGEPPSVSGGQQLLHSRFFDPKRYDLGRVGRYKINKKLRLTVPDEVRTLTHEDVLSTIDYLInlELDIGGASLDDIDHL 313
Cdd:TIGR02013  247 RPGEPPTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLI--KLRNGKGEIDDIDHL 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  314 GNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKR 393
Cdd:TIGR02013  325 GNRRIRSVGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKR 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  394 RISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWEVNNGRVNKEGNPVYL 473
Cdd:TIGR02013  405 RLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVVVTDEIDYL 484
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  474 SADLEDECRVAPGDVATDKDGNILANLIPVRYRQDFEKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQ 553
Cdd:TIGR02013  485 TADEEDNYVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQ 564
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  554 RQAVPLLRPERPLVGTGLESQVARDSGMVPITKVNGIVSYVDANEIVVKDTE------GNEHFHYLQKYQRSNQDTCLNQ 627
Cdd:TIGR02013  565 RQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYDEdeeepdGGIDIYRLLKYQRSNQDTCINQ 644
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  628 RPIVQIGDQVISGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGP 707
Cdd:TIGR02013  645 RPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGP 724
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  708 EEITREIPNISEESLNNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGR 787
Cdd:TIGR02013  725 EEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGT 804
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  788 VLDVRIYTREQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRM 867
Cdd:TIGR02013  805 VIDVKVFSREQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSRM 884
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  868 NVGQVFELLMGWAASNLNcrvkvvpfdeMYGAEKSHQTVQAFLEEASKQPGKAWVYNPDdpGKLLLKDGRTGEPFDQPVA 947
Cdd:TIGR02013  885 NIGQILETHLGWAGKRLG----------RKGVPIATPVFDGASEEEIKEYLEKAGLPRD--GKVRLYDGRTGEQFDRPVT 952
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  948 VGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALN 1027
Cdd:TIGR02013  953 VGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYE 1032
                         1050      1060      1070
                   ....*....|....*....|....*....|.
gi 2021943934 1028 AIVKGKPIPRPGTPESFKVLMRELQSLGLDI 1058
Cdd:TIGR02013 1033 AIVKGENVPEPGIPESFNVLIKELQSLGLDI 1063
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
18-1058 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 1002.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   18 LVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFIGEDYRLKRPRH---------DVEEAKRRDATFASQMYVTCR 88
Cdd:cd00653      1 LVKQQIDSFNYFLNVGLQEIVKSIPPITDTDDDGRLKLKFGDIYLGKPKVeeggvtrklTPNECRLRDLTYSAPLYVDIR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   89 LINKETGEIKEQEVFIGELPLMTE------------------------RGTFIINGAERVIVNQIVRSPGVYFKDeqDKN 144
Cdd:cd00653     81 LTVNDKGKIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQEQRSPNVIIVE--DSK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  145 GRRTY----NASVIPNRGAWLKFETD-KNNLLYVRVDKTRKinahvlmramglsdndvvdklrhpefyqssidsandegi 219
Cdd:cd00653    159 GKRIYtktsIPSYSPYRGSWLEVKSDkKKDRIYVRIDLKRQ--------------------------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  220 nseDQALLELYKKLrpgeppsvsggqqllhsrffdpkrydlgrvgrykinkklrltvpdevrtlthEDVLSTIDYLINLE 299
Cdd:cd00653    200 ---EEALKYIGKRF----------------------------------------------------EDLIYMIRKLILLV 224
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  300 LDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDS--LTPAQLVNPKPLVAAIKEFFGSSQ-- 375
Cdd:cd00653    225 LGKG--KLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKkdLTPQLLINSKPITSGIKEFLATGNwg 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  376 ----------LSQFMDQTNPLAELTHKRRISAlgpGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHAR 445
Cdd:cd00653    303 skrflmqrsgLSQVLDRLNPLSELSHKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMAR 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  446 VNeyGFIETPFWEVNNgrvnkegnpvylsadledecrvapgdvatdkdgnilanlipvryrqdfekvpphQVDYVQLSPV 525
Cdd:cd00653    380 IS--GRIERPYRIVEK------------------------------------------------------EVTHIEISPS 403
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  526 QVISVATSLIPFLEHDDANRALMGSNMQRQAVP----------------LLRPERPLVGTGLESQVARdsgmvpitkvng 589
Cdd:cd00653    404 QILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGtpalnqqyrmdtklylLLYPQKPLVGTGIEEYIAF------------ 471
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  590 ivsyvdaneivvkdtegnehfhylqkyqrsnqdtclnqrpivqigdqvisgqvladgsacegGEIALGQNVLIAYMPWEG 669
Cdd:cd00653    472 --------------------------------------------------------------GELPLGQNAIVAVMSYSG 489
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  670 YNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITR-EIPNISEESLNNLDEMGIIRIGAFVESGDILVGKVT 748
Cdd:cd00653    490 YNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKIT 569
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  749 PKGESDQPPeekllraIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREqgdeLPPGANMVVRVYVAQRRKIQVGDKMAG 828
Cdd:cd00653    570 PKGETESTP-------IFGEKARDVRDTSLKYPGGEKGIVDDVKIFSRE----LNDGGNKLVKVYIRQKRKPQIGDKFAS 638
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  829 RHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDEMYGAEKSHqtvqa 908
Cdd:cd00653    639 RHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISE----- 713
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  909 FLEEASKQPgkawvynpddPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGG 988
Cdd:cd00653    714 LLGEAGLNY----------YGKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGG 783
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  989 QRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIV----------KGKPIPRPGTPESFKVLMRELQSLGLDI 1058
Cdd:cd00653    784 QRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDP 863
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
584-985 2.23e-168

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 500.13  E-value: 2.23e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  584 ITKVNGIVSYVDANEIVVKDTEGNE--HFHYLQKYQRSNQDT---CLNQRPIVQIGDQVISGQvladgsacegGEIALGQ 658
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAMGKQamGIYTLNKFYRSDQNTyvlCYPQKPLVKTGAVEAGGF----------GELPLGQ 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  659 NVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEkyEIEARQTKLGP-EEITREIPNISEESLNNLDEMGIIRIGAFV 737
Cdd:pfam00562   71 NAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIK--EIEARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRVGAEV 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  738 ESGDILVGKVTPkgesdqPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTreqgdeLPPGANMVVRVYVAQR 817
Cdd:pfam00562  149 KPGDILVGKVGP------TELTKLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE------LPPGGIKMVKVYIRQK 216
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  818 RKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDemy 897
Cdd:pfam00562  217 RKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFD--- 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  898 GAEKSHQTVQAFLEEAskqpgkawVYNPDdpGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQ 977
Cdd:pfam00562  294 GASTEVEDIGELLEKA--------GYNYY--GKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTR 363

                   ....*...
gi 2021943934  978 QPLGGKAQ 985
Cdd:pfam00562  364 QPLGGRAR 371
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
15-1067 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2031.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFL-------EKGLIEELQNFSPISDYTGKLELHFIgeDYRLKRPRHDVEEAKRRDATFASQMYVTC 87
Cdd:PRK00405    24 LPNLLEIQLDSFDWFLqldvppeDEGLEEVFRSIFPIEDFNGNLSLEFV--SYELGEPKYDVEECKERGLTYSAPLRVKL 101
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   88 RLINKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDK--NGRRTYNASVIPNRGAWLKFET 165
Cdd:PRK00405   102 RLINKETGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHDKDKtsSGKLLYSARIIPYRGSWLEFEF 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  166 DKNNLLYVRVDKTRKINAHVLMRAMGLSDNDVVDKLRHPEFYQSSIDSAND----------------------------- 216
Cdd:PRK00405   182 DPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFGKEIEVPVEyllgkvlaedivdeetgevlaeandeite 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  217 -------------EGINSEDQALLELYKKLRPGEPPSVSGGQQLLHSRFFDPKRYDLGRVGRYKINKKLRLTVPDEVRTL 283
Cdd:PRK00405   262 eldgpyirntlekDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVL 341
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  284 THEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPL 363
Cdd:PRK00405   342 TKEDIIATIKYLINLRNGKG--EVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPV 419
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  364 VAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATH 443
Cdd:PRK00405   420 VAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATY 499
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  444 ARVNEYGFIETPFWEVNNGRVNKEgnPVYLSADLEDECRVAPGDVATDKDGNILANLIPVRYRQDFEKVPPHQVDYVQLS 523
Cdd:PRK00405   500 ARVNEYGFIETPYRKVVDGKVTDE--IVYLTADEEDNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVS 577
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  524 PVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLESQVARDSGMVPITKVNGIVSYVDANEIVVK- 602
Cdd:PRK00405   578 PKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRv 657
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  603 -----DTEGNEHFHyLQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAIL 677
Cdd:PRK00405   658 eeldpGEDGVDIYN-LIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAIL 736
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  678 VSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPP 757
Cdd:PRK00405   737 ISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTP 816
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  758 EEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTR-EQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGII 836
Cdd:PRK00405   817 EEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTRiEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVV 896
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  837 SRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDemyGAekSHQTVQAFLEEAskq 916
Cdd:PRK00405   897 SRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKFATPVFD---GA--KEEEIKELLEEA--- 968
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  917 pgkawvyNPDDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEV 996
Cdd:PRK00405   969 -------GLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEV 1041
                         1050      1060      1070      1080      1090      1100      1110
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2021943934  997 WALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIGVYTDEGKE 1067
Cdd:PRK00405  1042 WALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDEDGNE 1112
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
15-1065 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1849.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFigEDYRLKRPRHDVEEAKRRDATFASQMYVTCRLINKET 94
Cdd:COG0085     13 LPNLLEIQLDSFNWFLEEGLQEIFDEISPIEDFTGNLSLEF--GDYRLGEPKYTPEECKERDLTYAAPLYVKVRLVNKET 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   95 GEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDKNGRRTYNASVIPNRGAWLKFETDKNNLLYVR 174
Cdd:COG0085     91 GEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDKSGKDLYSAKVIPSRGAWLEFETDKDGTIYVR 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  175 VDKTRKINAHVLMRAMGL-SDNDVVDKLRHPEFYQSSIDSANDEGINSEDQALLELYKKLRPGEPPSVSGGQQLLHSRFF 253
Cdd:COG0085    171 IDRKRKIPVTVLLRALGLeTDEEILEAFGDDPIQEYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFF 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  254 DPKRYDLGRVGRYKINKKLRLTVPDEVRTLTHEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGL 333
Cdd:COG0085    251 DPKRYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGER--EPDDIDHLGNRRVRLVGELLQNQFRVGL 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  334 NRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVR 413
Cdd:COG0085    329 SRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVR 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  414 DIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWEVNNGRVNKEGnpVYLSADLEDECRVAPGDVATDKD 493
Cdd:COG0085    409 DVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEI--EYLTADEEENYYIAQANAPLDED 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  494 GNILANLIPVRYRQDFEKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVgtgles 573
Cdd:COG0085    487 GNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPLL------ 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  574 qvardsgmvpitkvngivsyvdaneivvkdtegnehfHY-LQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGG 652
Cdd:COG0085    561 -------------------------------------HYpLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNG 603
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  653 EIALGQNVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIR 732
Cdd:COG0085    604 ELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIR 683
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  733 IGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREQGDELPPGANMVVRV 812
Cdd:COG0085    684 IGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREEGDELPPGVNKLVRV 763
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  813 YVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVP 892
Cdd:COG0085    764 YVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPV 843
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  893 FDEMYGAEkshqtVQAFLEEAskqpgkawvyNPDDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPY 972
Cdd:COG0085    844 FDGAPEEE-----IRELLEKA----------GLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPY 908
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  973 SLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQ 1052
Cdd:COG0085    909 SLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQ 988
                         1050
                   ....*....|...
gi 2021943934 1053 SLGLDIGVYTDEG 1065
Cdd:COG0085    989 SLGLDVEVLSEDG 1001
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
10-1058 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1816.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   10 KTATYLPDLVEVQRASFKWFL----------EKGLIEELQNFSPISDYTGKLELHFIgeDYRLKRPRHDVEEAKRRDATF 79
Cdd:TIGR02013   12 PEVLEVPNLLEIQLDSYDWFLqqdtppekrkEEGLEEVFKSIFPIEDYTGNIELEYL--SYRLGEPKYSVEECKERGLTY 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   80 ASQMYVTCRLINKE---TGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQD--KNGRRTYNASVI 154
Cdd:TIGR02013   90 SAPLKVKLRLINKEedgTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKDttKSGKVLFSARII 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  155 PNRGAWLKFETDKNNLLYVRVDKTRKINAHVLMRAMGLSDNDV-VDKLRHPEFYQSSIDSandEGINSEDQALLELYKKL 233
Cdd:TIGR02013  170 PYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLiLNRLGSGEYIRNTLRK---DPTNSEEEALVEIYRKL 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  234 RPGEPPSVSGGQQLLHSRFFDPKRYDLGRVGRYKINKKLRLTVPDEVRTLTHEDVLSTIDYLInlELDIGGASLDDIDHL 313
Cdd:TIGR02013  247 RPGEPPTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLI--KLRNGKGEIDDIDHL 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  314 GNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKR 393
Cdd:TIGR02013  325 GNRRIRSVGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKR 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  394 RISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWEVNNGRVNKEGNPVYL 473
Cdd:TIGR02013  405 RLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVVVTDEIDYL 484
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  474 SADLEDECRVAPGDVATDKDGNILANLIPVRYRQDFEKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQ 553
Cdd:TIGR02013  485 TADEEDNYVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQ 564
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  554 RQAVPLLRPERPLVGTGLESQVARDSGMVPITKVNGIVSYVDANEIVVKDTE------GNEHFHYLQKYQRSNQDTCLNQ 627
Cdd:TIGR02013  565 RQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYDEdeeepdGGIDIYRLLKYQRSNQDTCINQ 644
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  628 RPIVQIGDQVISGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGP 707
Cdd:TIGR02013  645 RPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGP 724
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  708 EEITREIPNISEESLNNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGR 787
Cdd:TIGR02013  725 EEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGT 804
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  788 VLDVRIYTREQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRM 867
Cdd:TIGR02013  805 VIDVKVFSREQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSRM 884
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  868 NVGQVFELLMGWAASNLNcrvkvvpfdeMYGAEKSHQTVQAFLEEASKQPGKAWVYNPDdpGKLLLKDGRTGEPFDQPVA 947
Cdd:TIGR02013  885 NIGQILETHLGWAGKRLG----------RKGVPIATPVFDGASEEEIKEYLEKAGLPRD--GKVRLYDGRTGEQFDRPVT 952
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  948 VGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALN 1027
Cdd:TIGR02013  953 VGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYE 1032
                         1050      1060      1070
                   ....*....|....*....|....*....|.
gi 2021943934 1028 AIVKGKPIPRPGTPESFKVLMRELQSLGLDI 1058
Cdd:TIGR02013 1033 AIVKGENVPEPGIPESFNVLIKELQSLGLDI 1063
rpoB CHL00207
RNA polymerase beta subunit; Provisional
15-1078 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1658.68  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFIGEDYRLKRPRHDVEEAKRRDATFASQMYVTCRLINKET 94
Cdd:CHL00207     7 LPDFLEIQRTSFCWFLNEGLNEELNIFSKIFDYTGNLELLLFGKNYKLKYPKYNLLSAKSYDSNYSIQIYLPLKFINLKT 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   95 GEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDKNGRRTYNASVIPNRGAWLKFETDKNNLLYVR 174
Cdd:CHL00207    87 NKIKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIKKNSNKIYSATLIPNRGSWIKFELDKNKEIWIR 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  175 VDKTRKINAHVLMRAMGLSDNDVVDKLRHPEFYQSSIDSANDEGINSEDQALLELYKKLRPGEPPSVSGGQQLLHSRFFD 254
Cdd:CHL00207   167 IDKNRKKPLIIFLKALGLTDQDIYSRLTKSEFLKKLKPILLNSNSYTNEEILLEIYKNLSPIEPATVNDANQNLFSRFFD 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  255 PKRYDLGRVGRYKINKKLRLTVPDEVRTLTHEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGLN 334
Cdd:CHL00207   247 PKNYDLGKVGRYKINNKLNLNIPERVRNLTYEDILSIIDKLINLKINKG--NFDDIDHLKNRRVRSVGELLQNQFRIGLK 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  335 RLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRD 414
Cdd:CHL00207   325 RLERILRNRMTICDIDSLSKFNLINPKPLIALIREFFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRISFAVRD 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  415 IHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWEVNNGRVNKEGNPVYLSADLEDECRVAPGDVATDKDG 494
Cdd:CHL00207   405 IHPSHYGRICPIETPEGPNCGLIGSLATNARINKFGFIETPFYKVINGKVKKFGNPIYLTADSEDLYRIAPNDINLNKNN 484
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  495 NILANLIPVRYRQDFEKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLESQ 574
Cdd:CHL00207   485 YFKKNIIPVRYKQEFKTVNPSKVDFIAISPIQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIVGTGYEKQ 564
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  575 VARDSGMVPITKVNGIVSYVDANEIVVKDTEGNEHFHYLQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGGEI 654
Cdd:CHL00207   565 IALDSGMTIISLTEGIVVSVSAYKIIIQDDNNRYIHYYLQKYQRSNQNTCINYRPIVWVGEKINIGQILADGSDIDNSEL 644
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  655 ALGQNVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIRIG 734
Cdd:CHL00207   645 ALGQNVLVAYMPWEGYNFEDAILINKRLVYEDLFTSIHIEKYEIELRQTKLGSEEITRNIPNVSEYSLKNLDENGIISIG 724
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  735 AFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREQGDELPPGANMVVRVYV 814
Cdd:CHL00207   725 SKVLAGDILVGKITPKGESDQLPEGKLLRAIFGEKAKDVKDTSLRMPNGGYGRVIKVEIFSRSKGDELKFGYYLKIRVFI 804
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  815 AQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFD 894
Cdd:CHL00207   805 AQIRKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLGLAGDNLNKRFKILPFD 884
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  895 EMYGAEKSHQTVQAFLEEASKQPGKAWVYNPDDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSL 974
Cdd:CHL00207   885 EMYGSEYSRILINNKLNQASIKNNEYWLFNSYHPGKMVLRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKIHARTTGPYSL 964
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  975 VTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSL 1054
Cdd:CHL00207   965 VTQQPLGGKAQHGGQRFGEMEVWALEAFGAAYTLKELLTIKSDDMQGRNETLNAIVKGQPIPKPGTPESFKVLMRELQSL 1044
                         1050      1060      1070
                   ....*....|....*....|....*....|..
gi 2021943934 1055 GLDIGVY----TDEGK----EVDLMQDINPRR 1078
Cdd:CHL00207  1045 GLDIEAYkienFLEGQrleiEINLMENYKYFR 1076
rpoB CHL00001
RNA polymerase beta subunit
15-1061 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1579.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFIGEDYRLKRPRHDVEEAKRRDATFASQMYVTCRLINKET 94
Cdd:CHL00001    12 IPGFNQIQFEGFCRFIDQGLTEELSKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVPAGLIWKKS 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   95 GEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDKNGRRTYNASVIPNRGAWLKFETDKNNLLYVR 174
Cdd:CHL00001    92 RDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYRSELDHNGISVYTGTIISDWGGRLELEIDRKARIWAR 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  175 VDKTRKINAHVLMRAMGLSDNDVVDKLRHPEFYQSSIDSANDEGINSEDQALLELYKKL-RPGEPPSVSGG-QQLLHSRF 252
Cdd:CHL00001   172 VSRKQKISILVLLSAMGLNLREILDNVCYPEIFLSFLNDKEKKKIGSKENAILEFYQQFaCVGGDPVFSESlCKELQKKF 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  253 FDpKRYDLGRVGRYKINKKLRLTVPDEVRTLTHEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVG 332
Cdd:CHL00001   252 FQ-QRCELGRIGRRNMNRKLNLDIPENNTFLLPQDVLAAADYLIGMKFGMG--TLDDIDHLKNKRIRSVADLLQDQFGLA 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  333 LNRLERIIKERMTVGETDSL--TPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGF 410
Cdd:CHL00001   329 LNRLENAVRGTICGAIRRKLipTPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASF 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  411 AVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWEVNNgrVNKEGNPVYLSADLEDECRVAPGDVAT 490
Cdd:CHL00001   409 RVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHARIGHWGSLESPFYEISE--RSKEERMVYLSPSEDEYYMIAAGNSLA 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  491 DKDGNILANLIPVRYRQDFEKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTG 570
Cdd:CHL00001   487 LNQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTG 566
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  571 LESQVARDSGMVPITKVNGIVSYVDANEIVVKdTEGNEHFHYLQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACE 650
Cdd:CHL00001   567 LERQVALDSGVVAIAEHEGKIIYTDTDKIILS-GNGDTLSIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATV 645
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  651 GGEIALGQNVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGI 730
Cdd:CHL00001   646 GGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEIPHLEAHLLRNLDKNGI 725
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  731 IRIGAFVESGDILVGKVTPK--GESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRiytREQGDELPPGANM 808
Cdd:CHL00001   726 VMLGSWVETGDILVGKLTPQeaEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDVR---WIQKKGGSSYNPE 802
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  809 VVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRV 888
Cdd:CHL00001   803 TIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNRHY 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  889 KVVPFDEMYGAEKSHQTVQAFLEEASKQPGKAWVYNPDDPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARS 968
Cdd:CHL00001   883 RIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARS 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  969 TGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRP-GTPESFKVL 1047
Cdd:CHL00001   963 SGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTIPKPeDAPESFRLL 1042
                         1050
                   ....*....|....
gi 2021943934 1048 MRELQSLGLDIGVY 1061
Cdd:CHL00001  1043 VRELRSLALELNHF 1056
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
15-1067 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 1057.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFL------EKGLIEELQNFSPISDYTGKLELHFIGEDYrlKRPRHDVEEAKRRDATFASQMYVTCR 88
Cdd:PRK09603    24 VPNLLLLQRDSYDSFLyskdgkESGIEKVFKSIFPIQDEHNRITLEYAGCEF--GKSKYTVREAMERGITYSIPLKIKVR 101
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   89 LI----NKETGE------IKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQD--KNGRRTYNASVIPN 156
Cdd:PRK09603   102 LIlwekDTKSGEkngikdIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVIFKEEESstSLNKLIYTGQIIPD 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  157 RGAWLKFETDKNNLLYVRVDKTRKINAHVLMRAMGLSDNDVVdKLRHP-------------EFYQSSIDS---------- 213
Cdd:PRK09603   182 RGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDII-KMFYPlvkvryendkyliPFASLDANQrmefdlkdpq 260
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  214 ---------------------------------------------------------------------------AND-- 216
Cdd:PRK09603   261 gkiillagkkltsrkikelkenhlewveypmdillnrhlaepvmvgkevlldmltqldknklekihdlgvqefviINDla 340
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  217 ------------------------EGINSE-DQALLELYKKLRPGEPPSVSGGQQLLHSRFFDPKRYDLGRVGRYKINKK 271
Cdd:PRK09603   341 lghdasiihsfsadseslkllkqtEKIDDEnALAAIRIHKVMKPGDPVTTEVAKQFVKKLFFDPERYDLTMVGRMKMNHK 420
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  272 LRLTVPDEVRTLTHEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTV--GET 349
Cdd:PRK09603   421 LGLHVPDYITTLTHEDIITTVKYLMKIKNNQG--KIDDRDHLGNRRIRAVGELLANELHSGLVKMQKTIKDKLTTmsGAF 498
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  350 DSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETP 429
Cdd:PRK09603   499 DSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKDRVGFEARDVHPTHYGRICPIETP 578
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  430 EGPNAGLINSLATHARVNEYGFIETPFWEVNNGRVNKEgnPVYLSADLEDECRVAPGDVATDKDGNILANLIPVRYRQDF 509
Cdd:PRK09603   579 EGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGE--TIYLTAIQEDSHIIAPASTPIDEEGNILGDLIETRVEGEI 656
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  510 EKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLESQVARDSGMVPITKVNG 589
Cdd:PRK09603   657 VLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIVGTGIEKIIARDSWGAIKANRAG 736
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  590 IVSYVDANEIVV--KDTEGNEHFHY-LQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGGEIALGQNVLIAYMP 666
Cdd:PRK09603   737 VVEKIDSKNIYIlgEGKEEAYIDAYsLQKNLRTNQNTSFNQVPIVKVGDKVEAGQIIADGPSMDRGELALGKNVRVAFMP 816
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  667 WEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIRIGAFVESGDILVGK 746
Cdd:PRK09603   817 WNGYNFEDAIVVSERITKDDIFTSTHIYEKEVDARELKHGVEEFTADIPDVKEEALAHLDESGIVKVGTYVSAGMILVGK 896
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  747 VTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTR------------------------------ 796
Cdd:PRK09603   897 TSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTKkgyekdarvlsayeeekakldmehfdrltm 976
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934      --------------------------------------------------------------------------------
Cdd:PRK09603   977 lnreellrvssllsqaileepfshngkdykegdqipkeeiasinrftlaslvkkyskevqnhyeitknnfleqkkvlgee 1056
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  797 --------EQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMN 868
Cdd:PRK09603  1057 heeklsilEKDDILPNGVIKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMN 1136
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  869 VGQVFELLMGWAASNLNCRVKvvpfdEMYgaekSHQTVQAFLEEASKQPGKAWVYNPDDP-------------------- 928
Cdd:PRK09603  1137 IGQILEMHLGLVGKEFGKQIA-----SML----EDKTKDFAKELRAKMLEIANAINEKDPltihalencsdeelleyakd 1207
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  929 --------------------------------GKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVT 976
Cdd:PRK09603  1208 wskgvkmaipvfegisqekfyklfelakiamdGKMDLYDGRTGEKMRERVNVGYMYMIKLHHLVDEKVHARSTGPYSLVT 1287
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  977 QQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGL 1056
Cdd:PRK09603  1288 HQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKGEQVGESEIPETFYVLTKELQSLAL 1367
                         1370
                   ....*....|.
gi 2021943934 1057 DIGVYTDEGKE 1067
Cdd:PRK09603  1368 DINIFGDDVDE 1378
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
18-1058 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 1002.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   18 LVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFIGEDYRLKRPRH---------DVEEAKRRDATFASQMYVTCR 88
Cdd:cd00653      1 LVKQQIDSFNYFLNVGLQEIVKSIPPITDTDDDGRLKLKFGDIYLGKPKVeeggvtrklTPNECRLRDLTYSAPLYVDIR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   89 LINKETGEIKEQEVFIGELPLMTE------------------------RGTFIINGAERVIVNQIVRSPGVYFKDeqDKN 144
Cdd:cd00653     81 LTVNDKGKIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQEQRSPNVIIVE--DSK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  145 GRRTY----NASVIPNRGAWLKFETD-KNNLLYVRVDKTRKinahvlmramglsdndvvdklrhpefyqssidsandegi 219
Cdd:cd00653    159 GKRIYtktsIPSYSPYRGSWLEVKSDkKKDRIYVRIDLKRQ--------------------------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  220 nseDQALLELYKKLrpgeppsvsggqqllhsrffdpkrydlgrvgrykinkklrltvpdevrtlthEDVLSTIDYLINLE 299
Cdd:cd00653    200 ---EEALKYIGKRF----------------------------------------------------EDLIYMIRKLILLV 224
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  300 LDIGgaSLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDS--LTPAQLVNPKPLVAAIKEFFGSSQ-- 375
Cdd:cd00653    225 LGKG--KLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKkdLTPQLLINSKPITSGIKEFLATGNwg 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  376 ----------LSQFMDQTNPLAELTHKRRISAlgpGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHAR 445
Cdd:cd00653    303 skrflmqrsgLSQVLDRLNPLSELSHKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMAR 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  446 VNeyGFIETPFWEVNNgrvnkegnpvylsadledecrvapgdvatdkdgnilanlipvryrqdfekvpphQVDYVQLSPV 525
Cdd:cd00653    380 IS--GRIERPYRIVEK------------------------------------------------------EVTHIEISPS 403
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  526 QVISVATSLIPFLEHDDANRALMGSNMQRQAVP----------------LLRPERPLVGTGLESQVARdsgmvpitkvng 589
Cdd:cd00653    404 QILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGtpalnqqyrmdtklylLLYPQKPLVGTGIEEYIAF------------ 471
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  590 ivsyvdaneivvkdtegnehfhylqkyqrsnqdtclnqrpivqigdqvisgqvladgsacegGEIALGQNVLIAYMPWEG 669
Cdd:cd00653    472 --------------------------------------------------------------GELPLGQNAIVAVMSYSG 489
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  670 YNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITR-EIPNISEESLNNLDEMGIIRIGAFVESGDILVGKVT 748
Cdd:cd00653    490 YNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKIT 569
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  749 PKGESDQPPeekllraIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREqgdeLPPGANMVVRVYVAQRRKIQVGDKMAG 828
Cdd:cd00653    570 PKGETESTP-------IFGEKARDVRDTSLKYPGGEKGIVDDVKIFSRE----LNDGGNKLVKVYIRQKRKPQIGDKFAS 638
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  829 RHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDEMYGAEKSHqtvqa 908
Cdd:cd00653    639 RHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISE----- 713
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  909 FLEEASKQPgkawvynpddPGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGG 988
Cdd:cd00653    714 LLGEAGLNY----------YGKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGG 783
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  989 QRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIV----------KGKPIPRPGTPESFKVLMRELQSLGLDI 1058
Cdd:cd00653    784 QRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDP 863
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
15-1058 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 980.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   15 LPDLVEVQRASFKWFLEKGLIEE-----LQNFSPISDYTGKLELHFIgeDYRLKRPRHDVEEAKRRDATFASQMYVTCRL 89
Cdd:PRK14844    29 LLDLVKVQKESYDSFTPKNKGNErleviFHTIFPINDPLHRATIEFI--SCRVDDPKYDESECIKRGITFSAQVIASIRL 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   90 IN-------------KETGE----------IKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDK--- 143
Cdd:PRK14844   107 VImqdgisldeyksiKESGDhsklatviksIEEQEVHFCELPMMTDKGTFIINGVEKVIVSQMHRSPGVFFDSDKGKtyn 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  144 NGRRTYNASVIPNRGAWLKFETDKNNLLYVRVDKTRKINAHVLMRAMGLSDNDVVDK-------LRH---------PEFY 207
Cdd:PRK14844   187 SGKLIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALGLSNNDILDRfyekikyIKHkdgwkvpfvPDKF 266
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  208 QSS-----------------------------------------------------IDSAN------------------- 215
Cdd:PRK14844   267 KGVrlpfdlmdvegnvllkanvritsrlakklydnelkeylvpfdsicglflaedlIDSASstkilsagesikledikkl 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  216 ----------------------------DEGINSEDqALLELYKKLRPGEPPSVSGGQQLLHSRFFDPKRYDLGRVGRYK 267
Cdd:PRK14844   347 ellsideisvlnidnlsvgpyilntlflDENMSYQD-ALYEIYKVLRPGEVPVLEIVEEFFRNLFFSPEYYDLSNIGRLK 425
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  268 INKKLRLTVPDEVRTLTHEDVLSTIDYLINLEldIGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVG 347
Cdd:PRK14844   426 LNSYLGLNYDEDLTVLTHEDIIEIVRKIVLLR--DGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLLKLERAVVDSMSTS 503
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  348 ETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIE 427
Cdd:PRK14844   504 SLDKVSPSDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIE 583
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  428 TPEGPNAGLINSLATHARVNEYGFIETPFWEVNNGRVNKEGNpvYLSADLEDECRVAPGDVATDKDGNILANLIPVRYRQ 507
Cdd:PRK14844   584 TPEGQNIGLINSLAIYARINKYGFIESPYRKVVNRVVTDQIE--YLSAIDEGLYYIADTSAKLDENNCFVDDMLYCRYAG 661
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  508 DFEKVPPHQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLESQVARDSGMVPITKV 587
Cdd:PRK14844   662 SFVMVSSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVASGSGAVVLAKR 741
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  588 NGIVSYVDANEIVVK--DTEGNEHF----HYLQKYQRSNQDTCLNQRPIVQIGDQVISGQVLADGSACEGGEIALGQNVL 661
Cdd:PRK14844   742 DGIVDSSDSNSIVIRafDKERVNYLdvdiYHLRKFQRSNHNTCINQKPLVCVGDYVKEGDVIADGPAINSGELALGQNLL 821
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  662 IAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNISEESLNNLDEMGIIRIGAFVESGD 741
Cdd:PRK14844   822 VAFMSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNEENLYHLDDSGIVKIGTRVGPGY 901
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  742 ILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTR------------------------- 796
Cdd:PRK14844   902 ILVGKVTPKPSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRrgveenerallikqkeindfekerd 981
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  797 ----------------------------------------------------------------------------EQGD 800
Cdd:PRK14844   982 yiinvtseyfydelkkllinsgsqdrekfdsiereqwwgiglknqsiseqvkslkkdfdekvshaiaqfkrkveklHEGY 1061
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  801 ELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWA 880
Cdd:PRK14844  1062 DLPQGVSMSVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQILETHVGWA 1141
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  881 ASNLNCRV-----------------------------KVVPFD---------------------------------EMY- 897
Cdd:PRK14844  1142 CKKLGEKVgnildeinkiksafckgirslnddnftkfAAAYLDnkkienidddeitasvlntpnknalndelnelvENYl 1221
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  898 -GAEKSHQTVQAFL-------------------------EEASKQPGKAWVYNP-------------------DDPGKLL 932
Cdd:PRK14844  1222 nSCKSAYSNLRNFLievyscgsnvsicnnirdisdnnliEFARKLRDGIPVAAPvfegpkdeqiaklfelaglDNSGQAV 1301
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  933 LKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELL 1012
Cdd:PRK14844  1302 LYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEMECWALQAYGAAYTLQEML 1381
                         1370      1380      1390      1400
                   ....*....|....*....|....*....|....*....|....*.
gi 2021943934 1013 TVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDI 1058
Cdd:PRK14844  1382 TVKSDDINGRVKIYESIIKGDSNFECGIPESFNVMIKELRSLCLNV 1427
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
584-985 2.23e-168

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 500.13  E-value: 2.23e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  584 ITKVNGIVSYVDANEIVVKDTEGNE--HFHYLQKYQRSNQDT---CLNQRPIVQIGDQVISGQvladgsacegGEIALGQ 658
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAMGKQamGIYTLNKFYRSDQNTyvlCYPQKPLVKTGAVEAGGF----------GELPLGQ 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  659 NVLIAYMPWEGYNYEDAILVSERMVTDDLYTSVHIEkyEIEARQTKLGP-EEITREIPNISEESLNNLDEMGIIRIGAFV 737
Cdd:pfam00562   71 NAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIK--EIEARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRVGAEV 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  738 ESGDILVGKVTPkgesdqPPEEKLLRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTreqgdeLPPGANMVVRVYVAQR 817
Cdd:pfam00562  149 KPGDILVGKVGP------TELTKLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE------LPPGGIKMVKVYIRQK 216
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  818 RKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDemy 897
Cdd:pfam00562  217 RKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFD--- 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  898 GAEKSHQTVQAFLEEAskqpgkawVYNPDdpGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQ 977
Cdd:pfam00562  294 GASTEVEDIGELLEKA--------GYNYY--GKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTR 363

                   ....*...
gi 2021943934  978 QPLGGKAQ 985
Cdd:pfam00562  364 QPLGGRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
18-1057 3.37e-122

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 402.41  E-value: 3.37e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   18 LVEVQRASFKWFLEKGLIEELQNFSPISDYTGKLELHFigEDYRLKRPR----HDVE------EAKRRDATFASQMYVTC 87
Cdd:PRK08565    14 LVRQHLDSYNDFIERGLQEIVDEFGEIKTEIPGLKIVL--GKIRVGEPEikeaDGSErpitpmEARLRNLTYAAPLYLTM 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   88 RLINkETGEIKEQEVFIGELPLMTER------------------------GTFIINGAERVIVNQIVRSPGVYFKDEQDK 143
Cdd:PRK08565    92 IPVE-NGIEYEPEEVKIGDLPIMVKSkicplsglspdelieigedpkdpgGYFIINGSERVIVSQEDLAPNRVLVDKGEA 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  144 NGRRTYNASVIPNRG---AWLKFETDKNNLLYVRVDKTR-KINAHVLMRAMGL-SDNDVVDKLR-HPEFYQ---SSIDSA 214
Cdd:PRK08565   171 GSSITHTAKVISSRAgyrAQVTVERRKDGTIYVSFPAVPgKIPFVILMRALGLeTDRDIVYAVSlDPEIQQellPSLEQA 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  215 NDEGINSEDqALLELYKKLRPGEPPSV--SGGQQLLHSRFF-----DP-----KRYDLGRVGRykinkKLrltvpdevrt 282
Cdd:PRK08565   251 SSIAATVED-ALDYIGKRVAIGQPREYriERAEQILDKYLLphlgtSPedrikKAYFLGQMAS-----KL---------- 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  283 lthedvlstidylinLELDIGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERM--TVGETDSLTPAQLVNP 360
Cdd:PRK08565   315 ---------------LELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLKYQLekSYARGRKLDLRAIVRP 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  361 KPLVAAIKEFF-------GSSQLSQFMDQTNPLAELTHKRRIsaLGPggLTRERAGFAVRDIHPSHYGRLCPIETPEGPN 433
Cdd:PRK08565   380 DIITERIRHALatgnwvgGRTGVSQLLDRTNYLSTLSHLRRV--VSP--LSRGQPHFEARDLHGTQWGRICPFETPEGPN 455
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  434 AGLINSLATHAR----VNEYGFIET-------PFWEVNnGRVNKEGNPVYL-----------------------SADLED 479
Cdd:PRK08565   456 CGLVKNLALMAQisvgVDEEEVEEIlyelgvvPVEEAR-EEEYISWSRVYLngrligyhpdgeelaekirelrrSGKISD 534
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  480 ECRVAPGD--------VATDkDGNILANLIPVRY------RQDFEKVP-------------------------------P 514
Cdd:PRK08565   535 EVNVAYIEtgeinevyVNCD-SGRVRRPLIVVENgkpkltREHVEKLKkgeltfddlvkmgvieyldaeeeenayvaldP 613
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  515 HQV----DYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVpllrperplvgtGLESqvardsgmvpitkvngi 590
Cdd:PRK08565   614 EDLtpehTHLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSL------------GLYA----------------- 664
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  591 vsyvdANEIVVKDTEGneHF-HYlqkyqrsnqdtclNQRPIVQIGDQVISGqvLADGSAceggeialGQNVLIAYMPWEG 669
Cdd:PRK08565   665 -----ANFRIRTDTRG--HLlHY-------------PQRPLVQTRALEIIG--YNDRPA--------GQNAVVAVLSYTG 714
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  670 YNYEDAILVSERMVTDDLYTSVHIEKYEIEARQTkLGPEEITREIP--NIS----EESLNNLDEMGIIRIGAFVESGDIL 743
Cdd:PRK08565   715 YNIEDAIIMNKASIERGLARSTFFRTYETEERKY-PGGQEDKIEIPepNVRgyrgEEYYRKLDEDGIVSPEVEVKGGDVL 793
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  744 VGKVTPkgesdqP---PEEKLLRAIFGEKardvRDNSLRVPKTEKGRVLDVRIYTREQGDELppganmvVRVYVAQRRKI 820
Cdd:PRK08565   794 IGKTSP------PrflEELEELSLGLQER----RDTSVTVRHGEKGIVDTVLITESPEGNKL-------VKVRVRDLRIP 856
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  821 QVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDEmygaE 900
Cdd:PRK08565   857 ELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALEGRFVDATPFYG----E 932
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  901 KSHQTVQAFLEEASKQPGKAWVYnpddpgklllkDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPL 980
Cdd:PRK08565   933 PEEELRKELLKLGYKPDGTEVMY-----------DGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPT 1001
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  981 GGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSD-------DMQGRNEALNAIvKGKPI-PRPG---------TPES 1043
Cdd:PRK08565  1002 EGRAREGGLRFGEMERDCLIGHGAAMLLKERLLDSSDkttiyvcELCGHIAWYDRR-KNKYVcPIHGdkgnispveVSYA 1080
                         1210
                   ....*....|....
gi 2021943934 1044 FKVLMRELQSLGLD 1057
Cdd:PRK08565  1081 FKLLLQELMSMGIS 1094
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
519-1057 6.00e-72

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 251.10  E-value: 6.00e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  519 YVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVpllrperplvgtGLESqvardsgmvpitkvngivsyvdANE 598
Cdd:TIGR03670  118 HLEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSL------------GLYA----------------------ANY 163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  599 IVVKDTEGnehfHYLQkYQrsnqdtclnQRPIVQIGDQVISGqvLADGSAceggeialGQNVLIAYMPWEGYNYEDAILV 678
Cdd:TIGR03670  164 RIRLDTRG----HLLH-YP---------QKPLVKTRVLELIG--YDDRPA--------GQNFVVAVMSYEGYNIEDALIM 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  679 SERMVTDDLYTSVHIEKYEIEARQTKLGpEEITREIPNI------SEESLNNLDEMGIIRIGAFVESGDILVGKVTPkge 752
Cdd:TIGR03670  220 NKASIERGLARSTFFRTYEAEERRYPGG-QEDRFEIPEPdvrgyrGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSP--- 295
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  753 sdqpP---EEkllRAIFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREQGDELppganmvVRVYVAQRRKIQVGDKMAGR 829
Cdd:TIGR03670  296 ----PrflEE---LREFGLVTERRRDTSVTVRHGEKGIVDKVIITETEEGNKL-------VKVRVRDLRIPELGDKFASR 361
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  830 HGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLNCRVKVVPFDEmygaEKSHQTVQAF 909
Cdd:TIGR03670  362 HGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVAALEGRRVDGTPFEG----EPEEELRKEL 437
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  910 LEEASKQPGKAWVYnpddpgklllkDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQ 989
Cdd:TIGR03670  438 LKLGFKPDGKEVMY-----------DGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGL 506
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  990 RLGEMEVWALEAYGAAYTLQELLTVKSD-------DMQGRNEALNAIvKGKPI-PRPG---------TPESFKVLMRELQ 1052
Cdd:TIGR03670  507 RFGEMERDVLIGHGAAMLLKERLLDESDkyvvyvcENCGHIAWEDKR-KGTAYcPVCGetgdispveMSYAFKLLLDELK 585

                   ....*
gi 2021943934 1053 SLGLD 1057
Cdd:TIGR03670  586 SLGIS 590
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
519-1057 4.95e-65

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 231.77  E-value: 4.95e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  519 YVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVpllrperplvgtGLESqvardsgmvpitkvngivsyvdANE 598
Cdd:PRK07225   124 HLEIDPSLILGIGAGMIPYPEHNASPRITMGAGMIKQSL------------GLPA----------------------ANY 169
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  599 IVVKDTEGneHF-HYLQKyqrsnqdtclnqrPIVQIGDQVISGQvladgsacegGEIALGQNVLIAYMPWEGYNYEDAIL 677
Cdd:PRK07225   170 KLRPDTRG--HLlHYPQV-------------PLVKTQTQEIIGF----------DERPAGQNFVVAVMSYEGYNIEDALI 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  678 VSERMVTDDLYTSVHIEKYEIEARQTKLGPEEiTREIPNI------SEESLNNLDEMGIIRIGAFVESGDILVGKVTPKG 751
Cdd:PRK07225   225 MNKASIERGLGRSHFFRTYEGEERRYPGGQED-RFEIPDKdvrgyrGEEAYRHLDEDGLVNPETEVKEGDVLIGKTSPPR 303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  752 ESDQPPEekllraiFGEKARDVRDNSLRVPKTEKGRVLDVRIYTREQGDELppganmvVRVYVAQRRKIQVGDKMAGRHG 831
Cdd:PRK07225   304 FLEEPDD-------FGISPEKRRETSVTMRSGEEGIVDTVILTETEEGSRL-------VKVRVRDLRIPELGDKFASRHG 369
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  832 NKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASnLNC-RVKVVPFdemygaeksHQTVQAFL 910
Cdd:PRK07225   370 QKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEMIGGKVGS-LEGrRVDGTAF---------SGEDEEDL 439
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  911 EEASKQPGkawvYNPDdpGKLLLKDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQR 990
Cdd:PRK07225   440 REALEKLG----FEHT--GKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAREGGLR 513
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  991 LGEMEVWALEAYGAAYTLQELLTVKSDDMQ-------GRNEALNAIVKGKPIPRPGTPES---------FKVLMRELQSL 1054
Cdd:PRK07225   514 FGEMERDVLIGHGAAMLLKERLLDESDKVEiyvcakcGMIAIYDKKRNRKYCPICGEETDiypvemsyaFKLLLDELKSL 593

                   ...
gi 2021943934 1055 GLD 1057
Cdd:PRK07225   594 GIA 596
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
18-363 2.47e-44

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 166.02  E-value: 2.47e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   18 LVEVQRASFKWFLE---KGLIEE---LQNFSPISDYTG---KLELHFigEDYRLKRPRHDV----------EEAKRRDAT 78
Cdd:pfam04563    2 LVRQQLDSFNEFVDndlQKIIDEnalIESEFEIQHPGEngdKLSLKF--GQIRLGKPMFDEtdgstreiypQECRLRNLT 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   79 FASQMYVTCRLINKETGEIKEQEVFIGELPLMTE------------------------RGTFIINGAERVIVNQIVRS-- 132
Cdd:pfam04563   80 YSAPLYVDLELSVYNGEDIKPIEVFIGRLPIMLRsnacilsgateselvklgecpldpGGYFIINGSEKVIVAQEHRSrn 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  133 -PGVYFKDEQDK---NGRRTYNA--SVIPNRGAWLKF-ETDKNNLLYVRVDKTRK-INAHVLMRAMG-LSDNDVVDKLRH 203
Cdd:pfam04563  160 hPIVFKKADPKKrgsVASVRSSAeiSVRPDSTSWVNVlEYLSNGTIYFKFPYIKKeIPIVIILRALGfTSDREIFELICY 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  204 PE---FYQS----SIDSANDEGINSEDQALlelykklrpgeppsvsggqQLLHSRFFDPKRYDLGRVGRYKINKKLRLTv 276
Cdd:pfam04563  240 DVndqQLQEellpSLEEGFKIRIQTQEQAL-------------------DYIGGRGRAIFRMGRPREPRIKYAEEILQK- 299
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  277 pdevRTLTHEDVLST--------IDYLIN--LELDIGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERM-- 344
Cdd:pfam04563  300 ----EVLPHLGTYELdetkkayfIGYMIRrlLLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFKKLVRDVRERLqk 375
                          410
                   ....*....|....*....
gi 2021943934  345 TVGETDSLTPAQLVNPKPL 363
Cdd:pfam04563  376 VLGSPDDLMLQLLVNAKPI 394
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
17-448 3.26e-44

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 168.20  E-value: 3.26e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   17 DLVEVQRASFKWFLEKGLIEelqnfspISDYTGKLELHfIGEDYRLKRPRHDVE-----------------EAKRRDATF 79
Cdd:PRK09606    17 RLVRHHIDSYNDFVDNGLQK-------IIDEQGPIETE-IEDGVYVELGKIRVGkpvvkeadgsereiypmEARLRNLTY 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934   80 ASQMYVTCRLInKETGEIKEQEVFIGELPLM-------------TER-----------GTFIINGAERVIVNQIVRSPGV 135
Cdd:PRK09606    89 SAPLYLEMSPV-EGGEEEEPEEVYIGELPVMvgskicnlyglseEELievgedpldpgGYFIVNGSERVLMTLEDLAPNK 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  136 YFKDEQDKNGRRTYNASVIPNRG---AWLKFETDKNNLLYV---RVdkTRKINAHVLMRAMGL-SDNDVVDKL-RHPEFY 207
Cdd:PRK09606   168 ILVEKDERYGDRIEVAKVFSQRRgyrALVTVERNRDGLLEVsfpSV--PGSIPFVILMRALGLeTDEEIVEAVsDDPEIV 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  208 QSSIDSANDEGINSEDQALLELYKKLRPGEPpsvsggqqllhsrffdpKRYDLGRvGRYKINKKL--RLTVPDEVRtlth 285
Cdd:PRK09606   246 KFMLENLEEAEVDTQEEALEYIGKRVAPGQT-----------------KEYRIKR-AEYVIDRYLlpHLGVEPEVR---- 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  286 edvLSTIDYLIN-----LELDIGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIK---ERMTVGETDsLTPAQL 357
Cdd:PRK09606   304 ---RAKAHYLGRmaeacFELALGRREEDDKDHYANKRLKLAGDLMEDLFRVAFNRLARDVKyqlERANMRNRE-LSIKTA 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  358 VNPKPLVAAIKEFF-------GSSQLSQFMDQTNPLAELTHKRRISAlgpgGLTRERAGFAVRDIHPSHYGRLCPIETPE 430
Cdd:PRK09606   380 VRSDVLTERLEHAMatgnwvgGRTGVSQLLDRTDYMATLSHLRRVVS----PLSRSQPHFEARDLHPTQWGRICPSETPE 455
                          490
                   ....*....|....*...
gi 2021943934  431 GPNAGLINSLATHARVNE 448
Cdd:PRK09606   456 GPNCGLVKNFAQMVEIST 473
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
131-319 6.22e-42

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 151.73  E-value: 6.22e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  131 RSPGVYFKDEQDKNGR-RTYNASVIPNRGAWLKFETDKNNLLYVRVDKTRKINAHVLMRAMGL-SDNDVVDKLRHPEFYQ 208
Cdd:pfam04561    1 RSNGIYVEKELDKNGIiATYTSSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGLvSDREILDRLCYDFNDP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  209 SSIDSANDE-----GINSEDQALLELYK--KLRPGEPPSVSGGQQLLHSRFfdpkrydlgrvGRYKINKKLRLTVPDEVR 281
Cdd:pfam04561   81 QMLELLKPEleeaeNIYTQEEALDYIGKgfALRRGEEPRLQRAREILYSRD-----------PKYNLNKHLGLNEPFENE 149
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2021943934  282 TLTHEDVLSTIDYLINLELDIGgaSLDDIDHLGNRRVR 319
Cdd:pfam04561  150 RLKAQDILYMIDRLLNLKLGRR--KPDDIDHLGNKRVR 185
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
378-445 3.84e-36

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 130.72  E-value: 3.84e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2021943934  378 QFMDQTNPLAELTHKRRISAlGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHAR 445
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
987-1063 4.30e-33

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 122.70  E-value: 4.30e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  987 GGQRLGEMEVWALEAYGAAYTLQELLTVKSD----DMQGRNEALNA-----IVKGKPIPRPGT-PESFKVLMRELQSLGL 1056
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGYiPESFKLLFQELQSLGI 80

                   ....*..
gi 2021943934 1057 DIGVYTD 1063
Cdd:pfam04560   81 DPRLLLE 87
RNA_pol_Rpb2_45 pfam10385
RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent ...
459-523 2.45e-19

RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region.


Pssm-ID: 463067 [Multi-domain]  Cd Length: 66  Bit Score: 82.80  E-value: 2.45e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2021943934  459 VNNGRVNKEgnPVYLSADLEDECRVAPGDVATDKDGNILANLIPVRYRQDFEKVPPHQVDYVQLS 523
Cdd:pfam10385    4 VEDGKVTDE--IVYLTADEEDGYVIAQANAPLDEDGRFVDERVSARYRGEFPLVPPEEVDYMDVS 66
PRK00566 PRK00566
DNA-directed RNA polymerase subunit beta'; Provisional
583-648 8.87e-04

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 234794 [Multi-domain]  Cd Length: 1156  Bit Score: 43.52  E-value: 8.87e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021943934  583 PITKVNGIVSYV----DANEIVVKDTEGNEHFHYLQKyqrsnqdtclNQRPIVQIGDQVISGQVLADGSA 648
Cdd:PRK00566   930 IIAEIDGTVSFGketkGKRRIVITPDDGEEREYLIPK----------GKHLLVQEGDHVEAGDKLTDGSI 989
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH