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Conserved domains on  [gi|2023955780|ref|WP_209793528|]
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MULTISPECIES: carboxy-S-adenosyl-L-methionine synthase CmoA [Aeromonas]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 3-240 4.56e-142

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member TIGR00740:

Pssm-ID: 473071  Cd Length: 239  Bit Score: 397.46  E-value: 4.56e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780   3 DQIFAAPIARLGDFCFDEQVVDVFPDMIQRSVPGYSNIISAIGMMAARYAQPQSRLYDLGCSLGAATQAMRRHVNQPGCR 82
Cdd:TIGR00740   2 DTLFSAPIAKLGDFIFDENVAEVFPDMIQRSVPGYSNIISAIGMLAERFVQADSNVYDLGCSLGAATLSARRNIHHDNCK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  83 ITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENASVVVLNFTLQFVAPEKRAALIQRIFDGLRPGGILILSE 162
Cdd:TIGR00740  82 IIAIDNSPAMIERCRQHIAAYHAEIPVDIICGDIRDIAIENASMVILNFTLQFLEPEDRIALLDKIYEGLNPGGALVLSE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023955780 163 KFRFDDEQVNELLIDLHLDFKRANGYSELEISQKRTALENVMRTDTLAVHQARLRDAGFTHQDLWFQCFNFGSMIAIK 240
Cdd:TIGR00740 162 KFRFEDAKIGELLFDLHHDFKRANGYSELEISQKRSALENVMLTDSIETHKARLHNAGFEHSELWFQCFNFGSLIALK 239
 
Name Accession Description Interval E-value
TIGR00740 TIGR00740
tRNA (cmo5U34)-methyltransferase; This tRNA methyltransferase is involved, together with cmoB, ...
 3-240 4.56e-142

tRNA (cmo5U34)-methyltransferase; This tRNA methyltransferase is involved, together with cmoB, in preparing the uridine-5-oxyacetic acid (cmo5U) at position 34. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273244  Cd Length: 239  Bit Score: 397.46  E-value: 4.56e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780   3 DQIFAAPIARLGDFCFDEQVVDVFPDMIQRSVPGYSNIISAIGMMAARYAQPQSRLYDLGCSLGAATQAMRRHVNQPGCR 82
Cdd:TIGR00740   2 DTLFSAPIAKLGDFIFDENVAEVFPDMIQRSVPGYSNIISAIGMLAERFVQADSNVYDLGCSLGAATLSARRNIHHDNCK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  83 ITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENASVVVLNFTLQFVAPEKRAALIQRIFDGLRPGGILILSE 162
Cdd:TIGR00740  82 IIAIDNSPAMIERCRQHIAAYHAEIPVDIICGDIRDIAIENASMVILNFTLQFLEPEDRIALLDKIYEGLNPGGALVLSE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023955780 163 KFRFDDEQVNELLIDLHLDFKRANGYSELEISQKRTALENVMRTDTLAVHQARLRDAGFTHQDLWFQCFNFGSMIAIK 240
Cdd:TIGR00740 162 KFRFEDAKIGELLFDLHHDFKRANGYSELEISQKRSALENVMLTDSIETHKARLHNAGFEHSELWFQCFNFGSLIALK 239
PRK15451 PRK15451
carboxy-S-adenosyl-L-methionine synthase CmoA;
3-244 1.52e-117

carboxy-S-adenosyl-L-methionine synthase CmoA;


Pssm-ID: 185348  Cd Length: 247  Bit Score: 335.84  E-value: 1.52e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780   3 DQIFAAPIARLGDFCFDEQVVDVFPDMIQRSVPGYSNIISAIGMMAARYAQPQSRLYDLGCSLGAATQAMRRHVNQPGCR 82
Cdd:PRK15451    5 DTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  83 ITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENASVVVLNFTLQFVAPEKRAALIQRIFDGLRPGGILILSE 162
Cdd:PRK15451   85 IIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780 163 KFRFDDEQVNELLIDLHLDFKRANGYSELEISQKRTALENVMRTDTLAVHQARLRDAGFTHQDLWFQCFNFGSMIAIKAS 242
Cdd:PRK15451  165 KFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAE 244


                  ..
gi 2023955780 243 DP 244
Cdd:PRK15451  245 DA 246
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
54-162 1.12e-28

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 104.13  E-value: 1.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  54 PQSRLYDLGCSLGAATQAMRRHVnqPGCRITAVDLSHPMIERARAHLSGfksevpVELIEADICDIAI-ENASVVVLNFT 132
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERF--PGARVTGVDLSPEMLARARARLPN------VRFVVADLRDLDPpEPFDLVVSNAA 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 2023955780 133 LQFVapEKRAALIQRIFDGLRPGGILILSE 162
Cdd:COG4106    73 LHWL--PDHAALLARLAAALAPGGVLAVQV 100
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 60-156 6.99e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 83.77  E-value: 6.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  60 DLGCSLGAATQAMRRHVnqpGCRITAVDLSHPMIERARAHLSgfKSEVPVELIEADICDIAIENAS--VVVLNFTLQFVA 137
Cdd:pfam13649   3 DLGCGTGRLTLALARRG---GARVTGVDLSPEMLERARERAA--EAGLNVEFVQGDAEDLPFPDGSfdLVVSSGVLHHLP 77

                          90
                  ....*....|....*....
gi 2023955780 138 PEKRAALIQRIFDGLRPGG 156
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-161 4.65e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.00  E-value: 4.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  57 RLYDLGCSLGAATQAMRRHvnqPGCRITAVDLSHPMIERARAHLSGFKSEvPVELIEADICDI---AIENASVVVLNFTL 133
Cdd:cd02440     1 RVLDLGCGTGALALALASG---PGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELppeADESFDVIISDPPL 76

                          90       100
                  ....*....|....*....|....*...
gi 2023955780 134 QFVaPEKRAALIQRIFDGLRPGGILILS 161
Cdd:cd02440    77 HHL-VEDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
TIGR00740 TIGR00740
tRNA (cmo5U34)-methyltransferase; This tRNA methyltransferase is involved, together with cmoB, ...
 3-240 4.56e-142

tRNA (cmo5U34)-methyltransferase; This tRNA methyltransferase is involved, together with cmoB, in preparing the uridine-5-oxyacetic acid (cmo5U) at position 34. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273244  Cd Length: 239  Bit Score: 397.46  E-value: 4.56e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780   3 DQIFAAPIARLGDFCFDEQVVDVFPDMIQRSVPGYSNIISAIGMMAARYAQPQSRLYDLGCSLGAATQAMRRHVNQPGCR 82
Cdd:TIGR00740   2 DTLFSAPIAKLGDFIFDENVAEVFPDMIQRSVPGYSNIISAIGMLAERFVQADSNVYDLGCSLGAATLSARRNIHHDNCK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  83 ITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENASVVVLNFTLQFVAPEKRAALIQRIFDGLRPGGILILSE 162
Cdd:TIGR00740  82 IIAIDNSPAMIERCRQHIAAYHAEIPVDIICGDIRDIAIENASMVILNFTLQFLEPEDRIALLDKIYEGLNPGGALVLSE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023955780 163 KFRFDDEQVNELLIDLHLDFKRANGYSELEISQKRTALENVMRTDTLAVHQARLRDAGFTHQDLWFQCFNFGSMIAIK 240
Cdd:TIGR00740 162 KFRFEDAKIGELLFDLHHDFKRANGYSELEISQKRSALENVMLTDSIETHKARLHNAGFEHSELWFQCFNFGSLIALK 239
PRK15451 PRK15451
carboxy-S-adenosyl-L-methionine synthase CmoA;
3-244 1.52e-117

carboxy-S-adenosyl-L-methionine synthase CmoA;


Pssm-ID: 185348  Cd Length: 247  Bit Score: 335.84  E-value: 1.52e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780   3 DQIFAAPIARLGDFCFDEQVVDVFPDMIQRSVPGYSNIISAIGMMAARYAQPQSRLYDLGCSLGAATQAMRRHVNQPGCR 82
Cdd:PRK15451    5 DTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  83 ITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENASVVVLNFTLQFVAPEKRAALIQRIFDGLRPGGILILSE 162
Cdd:PRK15451   85 IIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780 163 KFRFDDEQVNELLIDLHLDFKRANGYSELEISQKRTALENVMRTDTLAVHQARLRDAGFTHQDLWFQCFNFGSMIAIKAS 242
Cdd:PRK15451  165 KFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAE 244


                  ..
gi 2023955780 243 DP 244
Cdd:PRK15451  245 DA 246
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
54-162 1.12e-28

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 104.13  E-value: 1.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  54 PQSRLYDLGCSLGAATQAMRRHVnqPGCRITAVDLSHPMIERARAHLSGfksevpVELIEADICDIAI-ENASVVVLNFT 132
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERF--PGARVTGVDLSPEMLARARARLPN------VRFVVADLRDLDPpEPFDLVVSNAA 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 2023955780 133 LQFVapEKRAALIQRIFDGLRPGGILILSE 162
Cdd:COG4106    73 LHWL--PDHAALLARLAAALAPGGVLAVQV 100
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 46-175 4.67e-22

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 88.51  E-value: 4.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  46 MMAARYAQPQSRLYDLGCSLGAATQAMRRHvnqpGCRITAVDLSHPMIERARAHLSgfKSEVPVELIEADICDIAIENAS 125
Cdd:COG2226    14 LLAALGLRPGARVLDLGCGTGRLALALAER----GARVTGVDISPEMLELARERAA--EAGLNVEFVVGDAEDLPFPDGS 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2023955780 126 --VVVLNFTLQFVaPEKRAALiQRIFDGLRPGGILILSEKFRFDDEQVNELL 175
Cdd:COG2226    88 fdLVISSFVLHHL-PDPERAL-AEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 60-156 6.99e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 83.77  E-value: 6.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  60 DLGCSLGAATQAMRRHVnqpGCRITAVDLSHPMIERARAHLSgfKSEVPVELIEADICDIAIENAS--VVVLNFTLQFVA 137
Cdd:pfam13649   3 DLGCGTGRLTLALARRG---GARVTGVDLSPEMLERARERAA--EAGLNVEFVQGDAEDLPFPDGSfdLVVSSGVLHHLP 77

                          90
                  ....*....|....*....
gi 2023955780 138 PEKRAALIQRIFDGLRPGG 156
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-161 4.15e-19

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 80.06  E-value: 4.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  49 ARYAQPQSRLYDLGCSLGAATQAMRRHvnqpGCRITAVDLSHPMIERARAHLsgfkSEVPVELIEADICDIAIENAS--V 126
Cdd:COG2227    19 ARLLPAGGRVLDVGCGTGRLALALARR----GADVTGVDISPEALEIARERA----AELNVDFVQGDLEDLPLEDGSfdL 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2023955780 127 VVLNFTLQFVapEKRAALIQRIFDGLRPGGILILS 161
Cdd:COG2227    91 VICSEVLEHL--PDPAALLRELARLLKPGGLLLLS 123
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 60-160 2.68e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 69.23  E-value: 2.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  60 DLGCSLGAATQAMRRHvnqpGCRITAVDLSHPMIERARAHLsgfkSEVPVELIEADICDIAIENAS--VVVLNFTLQFVa 137
Cdd:pfam08241   2 DVGCGTGLLTELLARL----GARVTGVDISPEMLELAREKA----PREGLTFVVGDAEDLPFPDNSfdLVLSSEVLHHV- 72

                          90       100
                  ....*....|....*....|...
gi 2023955780 138 pEKRAALIQRIFDGLRPGGILIL 160
Cdd:pfam08241  73 -EDPERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-161 4.65e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.00  E-value: 4.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  57 RLYDLGCSLGAATQAMRRHvnqPGCRITAVDLSHPMIERARAHLSGFKSEvPVELIEADICDI---AIENASVVVLNFTL 133
Cdd:cd02440     1 RVLDLGCGTGALALALASG---PGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELppeADESFDVIISDPPL 76

                          90       100
                  ....*....|....*....|....*...
gi 2023955780 134 QFVaPEKRAALIQRIFDGLRPGGILILS 161
Cdd:cd02440    77 HHL-VEDLARFLEEARRLLKPGGVLVLT 103
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 53-160 6.89e-15

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 69.96  E-value: 6.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  53 QPQSRLYDLGCSLGAATQAMRRHVnqpGCRITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENA-SVVVLNF 131
Cdd:COG2230    50 KPGMRVLDIGCGWGGLALYLARRY---GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQfDAIVSIG 126

                          90       100
                  ....*....|....*....|....*....
gi 2023955780 132 TLQFVAPEKRAALIQRIFDGLRPGGILIL 160
Cdd:COG2230   127 MFEHVGPENYPAYFAKVARLLKPGGRLLL 155
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-161 8.33e-15

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 70.72  E-value: 8.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  47 MAARYAQPQSRLYDLGCSLGAATQAMRRHVNQpgcRITAVDLSHPMIERARAHLSGFKSEvPVELIEADICDIAIENAS- 125
Cdd:COG0500    19 ALLERLPKGGRVLDLGCGTGRNLLALAARFGG---RVIGIDLSPEAIALARARAAKAGLG-NVEFLVADLAELDPLPAEs 94

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2023955780 126 --VVVLNFTLQFVAPEKRAALIQRIFDGLRPGGILILS 161
Cdd:COG0500    95 fdLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLS 132
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
46-161 1.16e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 69.64  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  46 MMAARYAQPQSRLYDLGCSLGAATQAMRRHvnqpGCRITAVDLSHPMIERARAHlsgfksEVPVELIEADICDIAIENAS 125
Cdd:COG4976    38 LLARLPPGPFGRVLDLGCGTGLLGEALRPR----GYRLTGVDLSEEMLAKAREK------GVYDRLLVADLADLAEPDGR 107

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2023955780 126 --VVVLNFTLQFVapEKRAALIQRIFDGLRPGGILILS 161
Cdd:COG4976   108 fdLIVAADVLTYL--GDLAAVFAGVARALKPGGLFIFS 143
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 60-158 7.81e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 60.07  E-value: 7.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  60 DLGCSLGAATQAMRRHvnQPGCRITAVDLSHPMIERARAHLS--GFKSEVPVELIEADICDIAIENASVVVLNFTLQFVA 137
Cdd:pfam08242   2 EIGCGTGTLLRALLEA--LPGLEYTGLDISPAALEAARERLAalGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLA 79

                          90       100
                  ....*....|....*....|.
gi 2023955780 138 peKRAALIQRIFDGLRPGGIL 158
Cdd:pfam08242  80 --DPRAVLRNIRRLLKPGGVL 98
Methyltransf_2 pfam00891
O-methyltransferase domain; This family includes a range of O-methyltransferases. These ...
 53-162 2.70e-10

O-methyltransferase domain; This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.


Pssm-ID: 395719 [Multi-domain]  Cd Length: 208  Bit Score: 58.19  E-value: 2.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  53 QPQSRLYDLGCSLGAATQAMRRHVnqPGCRITAVDLSHpMIERARAHLSgFKSEVPVELIEADICDIAIENASVVVLNFT 132
Cdd:pfam00891  59 SGFRSLVDVGGGTGALAQAIVSLY--PGCKGIVFDLPH-VVEAAPTHFS-AGEEPRVTFHGGDFFKDSLPEADAYILKRV 134

                          90       100       110
                  ....*....|....*....|....*....|
gi 2023955780 133 LQFVAPEKRAALIQRIFDGLRPGGILILSE 162
Cdd:pfam00891 135 LHDWSDEKCVKLLKRCYKACPAGGKVILVE 164
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 53-158 1.77e-09

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 56.49  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  53 QPQSRLYDLGCSLGAATQAMRRHVnqPGCRITAVDLSHPMIERARAHLSGfksevpVELIEADICDIA-IENASVVVLNF 131
Cdd:PRK01683   30 ENPRYVVDLGCGPGNSTELLVERW--PAARITGIDSSPAMLAEARSRLPD------CQFVEADIASWQpPQALDLIFANA 101

                          90       100
                  ....*....|....*....|....*..
gi 2023955780 132 TLQFVApeKRAALIQRIFDGLRPGGIL 158
Cdd:PRK01683  102 SLQWLP--DHLELFPRLVSLLAPGGVL 126
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 57-162 2.46e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.95  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  57 RLYDLGCSLGAATQAMRRHVNqPGCRITAVDLSHPMIERARAHLSGFKSEVpVELIEADI----CDIAIENASVVVLNFT 132
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELG-PNAEVVGIDISEEAIEKARENAQKLGFDN-VEFEQGDIeelpELLEDDKFDVVISNCV 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 2023955780 133 LQFVaPEKRAALiQRIFDGLRPGGILILSE 162
Cdd:pfam13847  84 LNHI-PDPDKVL-QEILRVLKPGGRLIISD 111
PRK08317 PRK08317
hypothetical protein; Provisional
 53-162 3.47e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.55  E-value: 3.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  53 QPQSRLYDLGCSLGAATQAMRRHVNqPGCRITAVDLSHPMIERARAHLSGfkSEVPVELIEADICDIAIENAS--VVVLN 130
Cdd:PRK08317   18 QPGDRVLDVGCGPGNDARELARRVG-PEGRVVGIDRSEAMLALAKERAAG--LGPNVEFVRGDADGLPFPDGSfdAVRSD 94

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2023955780 131 FTLQFVA-PEKRAALIQRIfdgLRPGGILILSE 162
Cdd:PRK08317   95 RVLQHLEdPARALAEIARV---LRPGGRVVVLD 124
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 56-162 1.92e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 43.57  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  56 SRLYDLGCSLGAATQAMRRHvnqpGCRITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDiaienasVVVLNFTLQF 135
Cdd:pfam13489  24 GRVLDFGCGTGIFLRLLRAQ----GFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPAGKFD-------VIVAREVLEH 92

                          90       100
                  ....*....|....*....|....*..
gi 2023955780 136 VAPEkrAALIQRIFDGLRPGGILILSE 162
Cdd:pfam13489  93 VPDP--PALLRQIAALLKPGGLLLLST 117
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 46-160 1.21e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.06  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  46 MMAARYAQPQSRLYDLGCSLGAATQAMRRHVNQPGcRITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENAS 125
Cdd:PRK00216   43 TIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTG-EVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNS 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2023955780 126 --VVVLNFTLQFVaPEKRAAL--IQRIfdgLRPGGIL-IL 160
Cdd:PRK00216  122 fdAVTIAFGLRNV-PDIDKALreMYRV---LKPGGRLvIL 157
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 42-99 5.44e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 40.13  E-value: 5.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2023955780  42 SAIGMMAARYAQPQSRLYDLGCSLGAatqaMRRHVNQPGCRITAVDLSHPMIERARAH 99
Cdd:PRK10258   30 SADALLAMLPQRKFTHVLDAGCGPGW----MSRYWRERGSQVTALDLSPPMLAQARQK 83
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 53-178 1.77e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 38.85  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023955780  53 QPQSRLYDLGCSLGAAtqaMRRHVNQPGCRITAVDLSHPMIERARAHLSGFKSEVPVELIEADICDIAIENASVVVLNFT 132
Cdd:pfam02353  60 KPGMTLLDIGCGWGGL---MRRAAERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMF 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2023955780 133 lQFVAPEKRAALIQRIFDGLRPGGILILSEKFRFDDEQVNELLIDL 178
Cdd:pfam02353 137 -EHVGHENYDTFFKKLYNLLPPGGLMLLHTITGLHPDETSERGLPL 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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