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Conserved domains on  [gi|2025822344|ref|WP_210421865|]
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helix-turn-helix domain-containing protein [Rhizobium anhuiense]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 14398448)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 42-123 3.43e-22

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 88.01  E-value: 3.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  42 ELPLHEHANGQLILALSGAVMCHVPGSIWIVPTGCAVWVPAGLRHRSPASPHSRICILFVKQDAAC-LPDYCCTLEITPL 120
Cdd:cd06124    13 RTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAgLPAEPCVLAVSPL 92


                  ...
gi 2025822344 121 VRE 123
Cdd:cd06124    93 LRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
190-268 2.97e-21

Helix-turn-helix domain;


:

Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.95  E-value: 2.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 190 WSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSD--GVPVQQVSEALGYESATSFITMFRKALGTTPSRYFD 267
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 2025822344 268 R 268
Cdd:pfam12833  81 R 81
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 42-123 3.43e-22

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 88.01  E-value: 3.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  42 ELPLHEHANGQLILALSGAVMCHVPGSIWIVPTGCAVWVPAGLRHRSPASPHSRICILFVKQDAAC-LPDYCCTLEITPL 120
Cdd:cd06124    13 RTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAgLPAEPCVLAVSPL 92


                  ...
gi 2025822344 121 VRE 123
Cdd:cd06124    93 LRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
190-268 2.97e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.95  E-value: 2.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 190 WSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSD--GVPVQQVSEALGYESATSFITMFRKALGTTPSRYFD 267
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 2025822344 268 R 268
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
5-273 5.02e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 84.06  E-value: 5.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344   5 IENLPITPVRAPTAAAWDVEFATPAMALLIGYDEDWVELPLHEHANGQLILALSGAVMCHVPGSIWIVPTGCAVWVPAGL 84
Cdd:COG2207     1 LRLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  85 RHRSPASPHSRICILFVKQDAACLPDYCCTLEITPLVREMVLRLVGTTVGSDADEHELRLMKVLLKELEgmptgglrlpv 164
Cdd:COG2207    81 LLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLL----------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 165 sSHPRMVAIQEALMAHPGDRTTLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQVSEALG 243
Cdd:COG2207   150 -LLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELG 228

                         250       260       270
                  ....*....|....*....|....*....|
gi 2025822344 244 YESATSFITMFRKALGTTPSRYFDRSDAKP 273
Cdd:COG2207   229 FSSQSHFSRAFKKRFGVTPSEYRKRLRARA 258
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
186-265 2.84e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 77.21  E-value: 2.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  186 TLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQVSEALGYESATSFITMFRKALGTTPSR 264
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   .
gi 2025822344  265 Y 265
Cdd:smart00342  83 Y 83
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 160-265 1.03e-17

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 81.36  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 160 LRLPVSSHPRMVAIQEALMAHPGDRTTLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQV 238
Cdd:COG4977   202 LVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLSIEEI 281

                          90       100
                  ....*....|....*....|....*..
gi 2025822344 239 SEALGYESATSFITMFRKALGTTPSRY 265
Cdd:COG4977   282 AAACGFGSASHFRRAFRRRFGVSPSAY 308
ftrA PRK09393
transcriptional activator FtrA; Provisional
 163-271 4.73e-12

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 64.99  E-value: 4.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 163 PVSSHP--RMVAIQEALMAHPGDRTTLAEWSGRTATSERTLARLvFRE-TGMTFGRWRQQLHLLVALSKL-SDGVPVQQV 238
Cdd:PRK09393  211 PVASREsdRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRR-FEAaTGMTPAEWLLRERLARARDLLeSSALSIDQI 289

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2025822344 239 SEALGYESATSFITMFRKALGTTPSRYFDRSDA 271
Cdd:PRK09393  290 AERAGFGSEESLRHHFRRRAATSPAAYRKRFGR 322
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 42-123 3.43e-22

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 88.01  E-value: 3.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  42 ELPLHEHANGQLILALSGAVMCHVPGSIWIVPTGCAVWVPAGLRHRSPASPHSRICILFVKQDAAC-LPDYCCTLEITPL 120
Cdd:cd06124    13 RTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAgLPAEPCVLAVSPL 92


                  ...
gi 2025822344 121 VRE 123
Cdd:cd06124    93 LRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
190-268 2.97e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.95  E-value: 2.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 190 WSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSD--GVPVQQVSEALGYESATSFITMFRKALGTTPSRYFD 267
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 2025822344 268 R 268
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
5-273 5.02e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 84.06  E-value: 5.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344   5 IENLPITPVRAPTAAAWDVEFATPAMALLIGYDEDWVELPLHEHANGQLILALSGAVMCHVPGSIWIVPTGCAVWVPAGL 84
Cdd:COG2207     1 LRLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  85 RHRSPASPHSRICILFVKQDAACLPDYCCTLEITPLVREMVLRLVGTTVGSDADEHELRLMKVLLKELEgmptgglrlpv 164
Cdd:COG2207    81 LLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLL----------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 165 sSHPRMVAIQEALMAHPGDRTTLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQVSEALG 243
Cdd:COG2207   150 -LLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELG 228

                         250       260       270
                  ....*....|....*....|....*....|
gi 2025822344 244 YESATSFITMFRKALGTTPSRYFDRSDAKP 273
Cdd:COG2207   229 FSSQSHFSRAFKKRFGVTPSEYRKRLRARA 258
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
186-265 2.84e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 77.21  E-value: 2.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  186 TLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQVSEALGYESATSFITMFRKALGTTPSR 264
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   .
gi 2025822344  265 Y 265
Cdd:smart00342  83 Y 83
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 160-265 1.03e-17

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 81.36  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 160 LRLPVSSHPRMVAIQEALMAHPGDRTTLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQV 238
Cdd:COG4977   202 LVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLSIEEI 281

                          90       100
                  ....*....|....*....|....*..
gi 2025822344 239 SEALGYESATSFITMFRKALGTTPSRY 265
Cdd:COG4977   282 AAACGFGSASHFRRAFRRRFGVSPSAY 308
ftrA PRK09393
transcriptional activator FtrA; Provisional
 163-271 4.73e-12

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 64.99  E-value: 4.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 163 PVSSHP--RMVAIQEALMAHPGDRTTLAEWSGRTATSERTLARLvFRE-TGMTFGRWRQQLHLLVALSKL-SDGVPVQQV 238
Cdd:PRK09393  211 PVASREsdRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRR-FEAaTGMTPAEWLLRERLARARDLLeSSALSIDQI 289

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2025822344 239 SEALGYESATSFITMFRKALGTTPSRYFDRSDA 271
Cdd:PRK09393  290 AERAGFGSEESLRHHFRRRAATSPAAYRKRFGR 322
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 175-276 2.23e-10

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 60.45  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 175 EALMAHPGDRTTLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDGVPVQQVSEALGYESATSFITMF 254
Cdd:COG2169    91 RLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLSRFYEAF 170

                          90       100
                  ....*....|....*....|..
gi 2025822344 255 RKALGTTPSRYfdRSDAKPRRL 276
Cdd:COG2169   171 KKLLGMTPSAY--RRGGAGAAI 190
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
42-106 1.36e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 46.00  E-value: 1.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2025822344  42 ELPLHEHANGQLILALSGAVMCHVPGSIWIVPTGCAVWVPAGLRHRSPASPHSRICILFVKQDAA 106
Cdd:COG1917    35 RTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVFSPGL 99
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 189-269 1.74e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 45.30  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 189 EWSGRTATSE----RTLARLVFRETGMTFG------RWRQQLHLLVAlsklsDGVPVQQVSEALGYESATSFITMFRKAL 258
Cdd:PRK09978  158 EWTLARIASEllmsPSLLKKKLREEETSYSqlltecRMQRALQLIVI-----HGFSIKRVAVSCGYHSVSYFIYVFRNYY 232

                          90
                  ....*....|.
gi 2025822344 259 GTTPSRYFDRS 269
Cdd:PRK09978  233 GMTPTEYQERS 243
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
173-268 8.54e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 43.35  E-value: 8.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 173 IQEALMAHPGDRTTLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVA--LSKLSDGVpVQQVSEALGYESATSF 250
Cdd:PRK13501  181 IMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAkcLLRGSEHR-ISDIAARCGFEDSNYF 259

                          90
                  ....*....|....*...
gi 2025822344 251 ITMFRKALGTTPSRYFDR 268
Cdd:PRK13501  260 SAVFTREAGMTPRDYRQR 277
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
163-265 4.67e-04

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 40.73  E-value: 4.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 163 PVSSHPRMVA-IQEA---LMAHPGDRTTLAEWSGRTATSERTLARLvFRE-TGMTFGRWR------QQLHLLValsklSD 231
Cdd:PRK10572  174 PESLHPPMDPrVREAcqyISDHLASEFDIESVAQHVCLSPSRLAHL-FRQqLGISVLRWRedqrisRAKLLLQ-----TT 247

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2025822344 232 GVPVQQVSEALGYESATSFITMFRKALGTTPSRY 265
Cdd:PRK10572  248 RMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEF 281
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
42-87 5.82e-04

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 38.58  E-value: 5.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2025822344  42 ELPLHEHANG-QLILALSGAVMCHVPGSIWIVPTGCAVWVPAGLRHR 87
Cdd:COG0662    39 ELSLHVHPHRdEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHR 85
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
122-272 7.52e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 40.42  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 122 REMVLRLVGTTVGSDADEHELR--LMKVLLKELEGMPTGGLRLPVSSHPRMVAIQEALMAHPGDRT-TLAEWSGRTATSE 198
Cdd:PRK13502  127 RQVINQLEHESNGRDPLANEMAelLFGQLVMTLKRHRYATDDLPATSRETLLDKLITALANSLECPfALDAFCQQEQCSE 206

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2025822344 199 RTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQVSEALGYESATSFITMFRKALGTTPSRYFDRSDAK 272
Cdd:PRK13502  207 RVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSpLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRHLSNQS 281
cupin_DAD_ChrR cd02237
2,4'-Dihydroxyacetophenone dioxygenase (DAD) and anti-sigma factor ChrR, and similar proteins; ...
 43-102 9.47e-04

2,4'-Dihydroxyacetophenone dioxygenase (DAD) and anti-sigma factor ChrR, and similar proteins; cupin domain; This family includes the proteins 2,4'-Dihydroxyacetophenone dioxygenase (DAD) and anti-sigma factor ChrR. DAD catalyzes the oxidation of 2,4'-dihydroxyacetophenone to 4-hydroxybenzoate and formate as part of the 4-hydroxyacetophenone catabolic pathway. The enzyme is a homotetramer containing one iron per molecule of enzyme. Anti-sigma factor ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the Rsp extra cytoplasmic function (ECF) sigma factor E (sigmaE). Some ChrR members contain tandem repeats of two distinct homologous functional domains. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380365 [Multi-domain]  Cd Length: 82  Bit Score: 37.37  E-value: 9.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344  43 LPLHEHANGQLILALSGAVMChvpgSIWIVPTGCAVWVPAGLRHrSPASPhSRICILFVK 102
Cdd:cd02237    27 LPDHEHVGGEEFYVLDGALTD----EDGTAGAGDFVREPPGSRH-SAVAP-REGCLILVI 80
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 226-265 1.27e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.98  E-value: 1.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2025822344 226 LSKLSDGVPVQQVSEALGYeSATSFITMFRKALGTTPSRY 265
Cdd:pfam00165   2 RENLSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQY 40
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
163-265 3.31e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 38.54  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025822344 163 PVSSHPRMVAIQEALMAHPGDRTTLAEWSGRTATSERTLARLVFRETGMTFGRWRQQLHLLVALSKLSDG-VPVQQVSEA 241
Cdd:PRK13500  201 PTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSrLLISDISTE 280

                          90       100
                  ....*....|....*....|....
gi 2025822344 242 LGYESATSFITMFRKALGTTPSRY 265
Cdd:PRK13500  281 CGFEDSNYFSVVFTRETGMTPSQW 304
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
186-262 8.01e-03

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 36.96  E-value: 8.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2025822344 186 TLAEwsgRTATSERTLARLVFRETGMTFGRWRQQLHLLVA--LSKLSDGvPVQQVSEALGYESATSFITMFRKALGTTP 262
Cdd:PRK13503  192 ALAD---QFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKArhLLRHSDA-SVTDIAYRCGFGDSNHFSTLFRREFSWSP 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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