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Conserved domains on  [gi|2026112259|ref|WP_210424293|]
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MarR family transcriptional regulator, partial [Mycobacterium tuberculosis]

Protein Classification

MarR family transcriptional regulator( domain architecture ID 10470737)

MarR family transcriptional regulator is a winged helix-turn-helix domain-containing protein, named for an Escherichia coli regulator of an operon that encodes a drug efflux pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 42-99 3.02e-15

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


:

Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 63.72  E-value: 3.02e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 2026112259 42 LTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRA 99
Cdd:pfam01047  1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
 
Name Accession Description Interval E-value
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 42-99 3.02e-15

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 63.72  E-value: 3.02e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 2026112259 42 LTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRA 99
Cdd:pfam01047  1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-99 4.98e-13

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 60.37  E-value: 4.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026112259   4 SEFTAPEVTQLAEGLHRALSKLISMLRRGdpngAAAGDLTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLE 83
Cdd:COG1846     2 SDEPDPAEERLGLLLRRLARALRRALDRA----LAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLE 77

                          90
                  ....*....|....*.
gi 2026112259  84 KIGLVKRSRDPSDLRA 99
Cdd:COG1846    78 EKGLVEREPDPEDRRA 93
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
41-99 3.71e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 57.22  E-value: 3.71e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2026112259   41 DLTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRA 99
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRS 65
 
Name Accession Description Interval E-value
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 42-99 3.02e-15

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 63.72  E-value: 3.02e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 2026112259 42 LTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRA 99
Cdd:pfam01047  1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-99 4.98e-13

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 60.37  E-value: 4.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026112259   4 SEFTAPEVTQLAEGLHRALSKLISMLRRGdpngAAAGDLTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLE 83
Cdd:COG1846     2 SDEPDPAEERLGLLLRRLARALRRALDRA----LAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLE 77

                          90
                  ....*....|....*.
gi 2026112259  84 KIGLVKRSRDPSDLRA 99
Cdd:COG1846    78 EKGLVEREPDPEDRRA 93
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
41-99 3.71e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 57.22  E-value: 3.71e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2026112259   41 DLTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRA 99
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRS 65
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 4.14e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 45.66  E-value: 4.14e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2026112259 41 DLTLAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRA 99
Cdd:pfam12802  2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
24-93 5.12e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.78  E-value: 5.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026112259  24 KLISMLRRGdpngaaagdltlAQLSILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRD 93
Cdd:COG3398    89 KILAYLRRE------------TPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERD 146
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
49-93 9.00e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.95  E-value: 9.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2026112259  49 ILVTLLDQGPIRMTDLAAHERVRTPTTTVAIRRLEKIGLVKRSRD 93
Cdd:COG1321    15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPY 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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