|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
20-427 |
1.29e-149 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 431.01 E-value: 1.29e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 20 VFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILM 99
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 100 ACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIM 179
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 180 YALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRnnldespayestleeqeeleysykdifkkywRDIIVCFTGVAFLNVAN 259
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR-------------------------------RPLLICIGLVLVFNVTN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 260 YMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMII 339
Cdd:cd17366 210 YMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIF 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 340 IGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGLLV 419
Cdd:cd17366 290 IGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVGLVA 369
|
....*...
gi 2026912915 420 FVFMFKTT 427
Cdd:cd17366 370 VLFLTETA 377
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
6-454 |
9.33e-129 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 382.14 E-value: 9.33e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 6 DNVNVVDASKTKKTVFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSHIGDK 85
Cdd:PRK10642 4 RDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 86 HGRKVVLSSTIILMACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGT 165
Cdd:PRK10642 84 YGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 166 LSGNILAAALVGIMYALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYESTLEEQEELE---------YSYKD 236
Cdd:PRK10642 164 IAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDreglqdgpkVSFKE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 237 IFKKYWRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGL 316
Cdd:PRK10642 244 IATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGS 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 317 IGFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIgAAVFGGLTPFILTTLV 396
Cdd:PRK10642 324 VALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLV 402
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 2026912915 397 ETTGQKIAPSYYLTVINVIGLLVFVFMfKTTSNKSLRGSYPNVDNKKDLHEVFENPKD 454
Cdd:PRK10642 403 ESTQNLMMPAYYLMVVAVIGLITGVTM-KETANRPLKGATPAASDIQEAKEILVEHYD 459
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
17-422 |
2.44e-107 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 324.09 E-value: 2.44e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 17 KKTVFATGIGNAIEWFDFGLYAQLAVIISSN-FFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSST 95
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKlFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 96 IILMACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAAL 175
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 176 VGIMYALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYESTLEEQEELEYSYKDIFKKYWRDIIVcFTGVAFL 255
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLL-AIGLRLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 256 -NVANYMVLSYMPSFlnGTIDLGGTMSSVLSTVTMAA--MIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFMSI 332
Cdd:cd17369 240 eNVLFYLFTTFALSY--ATQTLGVDRSTVLLAVLIASvvAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 333 PSIPMIIIG-LFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVFGGLTPFILTTLVETTGQKIAPSYYLTV 411
Cdd:cd17369 318 GSTWLIVLAaVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLAA 397
|
410
....*....|.
gi 2026912915 412 INVIGLLVFVF 422
Cdd:cd17369 398 LAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
26-417 |
1.97e-105 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 318.83 E-value: 1.97e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 26 GNAIEWFDFGLYAQLAVIISSNFFGNMPKE-IQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTL 104
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPlVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 105 VLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYALLS 184
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 185 DEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYESTLEEQEELEYSYKDIFKKYWRDIIVCFTGVAFLNVANYMVLS 264
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 265 YMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNT-ILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLF 343
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVlIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2026912915 344 IIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGL 417
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
20-427 |
1.07e-90 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 281.49 E-value: 1.07e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 20 VFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILM 99
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 100 ACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIM 179
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 180 YALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYESTLEEQEELEYSYKDiFKKYWRDIIVCFTGVAFLNVAN 259
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRE-LRRHPRELLLVVGLTAGGTLAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 260 YMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMII 339
Cdd:cd17367 240 YTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 340 IGLFIIAL-FMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVFGGLTPFILTTLVeTTGQKIAPSYYLTVINVIGLL 418
Cdd:cd17367 320 FALVLVGLvFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLK-SIGHEWVFFWYVAGLIAISLV 398
|
....*....
gi 2026912915 419 VFVFMFKTT 427
Cdd:cd17367 399 VYLRMPETR 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
20-426 |
5.37e-77 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 246.13 E-value: 5.37e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 20 VFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILM 99
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 100 ACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGleigTLSGNILAAALVGIM 179
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSW----QSASQQVAIVAGALV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 180 YALLS----DEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYestLEEQEELEY-SYKDIFKKYWRDIIVCFTGVAF 254
Cdd:cd17368 157 GYLLSltltAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAF---LERKARPTRrELFALLANNRRIILLGMLLVAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 255 LNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAF-WFMSIP 333
Cdd:cd17368 234 STVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFaWLTAAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 334 SIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVFGGLTPFILTTLVETTGQKIAPSYYLTVIN 413
Cdd:cd17368 314 SFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAA 393
|
410
....*....|...
gi 2026912915 414 VIGLLVFVFMFKT 426
Cdd:cd17368 394 LLGLLATLMLRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-419 |
1.41e-69 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 225.17 E-value: 1.41e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 20 VFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPkeiqLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILM 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLS----LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 100 ACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIM 179
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 180 YALLSDEqmaaWGWRIPFIIAAPLGIVGVYLRnnldespayestleeqeeleysykdifkkywRDIIVCFTGVAFLNVAN 259
Cdd:cd17316 149 IPLLSGD----WGWRILFLIGALPALLALLLR-------------------------------RRTLLLILLWFFISFGY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 260 YMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFsVVAFWFMSIPSIPMII 339
Cdd:cd17316 194 YGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL-ALPLFYLLSGSPTLLL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 340 IGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVFGGlTPFILTTLVETTGQKIAPSYYLTVINVIGLLV 419
Cdd:cd17316 273 LLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGG-APPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
5-419 |
1.30e-58 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 198.88 E-value: 1.30e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 5 KDNVNVVDASKTKKTVFA---TGIGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSH 81
Cdd:PRK10406 6 VTADSKLTSSDTRRRIWAivgASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 82 IGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGL 161
Cdd:PRK10406 86 IADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 162 EIGTLSGNILAAALVGIMYALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESpayestlEEQEELEYSYKDIFKKY 241
Cdd:PRK10406 166 YVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET-------SQQETRALKEAGSLKGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 242 WRD-----IIVCFTGVAFLNVanYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTIL-FG 315
Cdd:PRK10406 239 WRNrrafiMVLGFTAAGSLCF--YTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLcFG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 316 LIGfSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPS-IFHTKVRLRTLSLVYNIGAAVFGGLTPFILTT 394
Cdd:PRK10406 317 SLA-ALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVRALGVGLSYAVANALFGGSAEYVALS 395
|
410 420
....*....|....*....|....*
gi 2026912915 395 LvETTGQKIAPSYYLTVINVIGLLV 419
Cdd:PRK10406 396 L-KSIGMETAFFWYVTLMAVVAFLV 419
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
18-426 |
5.62e-55 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 189.38 E-value: 5.62e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 18 KTVFATGIGNAIEWFDFGLYAQLAVIISSNFFgnmPKEIQLAS---TFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSS 94
Cdd:PRK15075 15 RAILRVTSGNFLEMFDFFLFGFYATAIAKTFF---PAGNEFASlmlTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 95 TIILMACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSgLEIGTLSGNILAAA 174
Cdd:PRK15075 92 TLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTS-WQSASQQVAVVFAA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 175 LVG-IMYALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYestleEQEELEYSYKDIFK---KYWRDIIVCFT 250
Cdd:PRK15075 171 LLGyLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEF-----LARKHRPSMREIFRslaANWRIVLAGML 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 251 GVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVlstVTMAAMIPAVFF---FGWYSDKVGNKNTilfgLIGFSLFSV--- 324
Cdd:PRK15075 246 MVAMTTVSFYLITVYTPTFGKTVLHLSAADSLL---VTLCVGVSNFIWlpiGGALSDRIGRRPV----LIAFTVLAIlta 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 325 --VAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVFGGLTPFILTTLVETTGQK 402
Cdd:PRK15075 319 ypALSWLVAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDK 398
|
410 420
....*....|....*....|....
gi 2026912915 403 IAPSYYLTVINVIGLLVFVFMFKT 426
Cdd:PRK15075 399 AAPGYWLSFAAVCGLIATLVLYRR 422
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
14-423 |
9.82e-49 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 172.61 E-value: 9.82e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 14 SKTKKTVFATGIGNAIEWFDFGLYAQLAVII-SSNFFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVL 92
Cdd:PRK09952 18 SRARRAALGSFAGAVVDWYDFLLYGITAALVfNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRML 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 93 SSTIILMACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILA 172
Cdd:PRK09952 98 MLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 173 AALVGIMYALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYEstlEEQEELEYSYKDI---------FKKYWR 243
Cdd:PRK09952 178 TGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFE---QQQHEQAAAKKRIpvieallrhPGAFLK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 244 DIIVCFTGVAFLNVANYMVLSY------MPS--FLNGTIDLGGtmssvLSTVTmaamIPavfFFGWYSDKVGNKNTILFG 315
Cdd:PRK09952 255 IIALRLCELLTMYIVTAFALNYstqnlgLPRelFLNIGLLVGG-----LSCLT----IP---CFAWLADRFGRRRVYITG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 316 -LIGfsLFSVVAFwFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLP---SIFHTKVRLRTLSLVYNIGAAVFGGLTPFI 391
Cdd:PRK09952 323 aLIG--TLSAFPF-FMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPmftEMFGASYRYSGAGVGYQVASVVGGGFTPFI 399
|
410 420 430
....*....|....*....|....*....|...
gi 2026912915 392 LTTLVETTGQKIAP-SYYLTVINVIGLLVFVFM 423
Cdd:PRK09952 400 AAALVTYFGGSWHSvAIYLLAGCLISAMTALLM 432
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-383 |
3.94e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 130.86 E-value: 3.94e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 12 DASKTKKTVFATGIGNAIEWFDFGLYAQLAVIISSNFFGNmPKEIQLASTFAVFAFAfivrpIGGIFFSHIGDKHGRKVV 91
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAA-----LGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 92 LSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNIL 171
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPS--------LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 172 AAALVGIMyallsdeqMAAWGWRIPFIIAAPLGIVG-VYLRNNLDESPAyestlEEQEELEYSYKDIFKkyWRDIIVCFT 250
Cdd:COG2814 150 GPLLGGLL--------ADLFGWRWVFLVNAVLALLAlLLLLRLLPESRP-----AARARLRGSLRELLR--RPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 251 GVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIgfsLFSVVAFWFM 330
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL---LLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2026912915 331 SIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSL---VYNIGAAV 383
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLynsAFFLGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-427 |
1.68e-32 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 126.91 E-value: 1.68e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 18 KTVFATGIGNAIEWFDFGLYAQLAVIISSNFFgnmpkeIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTII 97
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLG------LSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 98 LMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVG 177
Cdd:COG2271 84 LWGLATLLFGFATS--------FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 178 IMyallsdeqMAAWGWRIPFIIAAPLGIVGVYLRnnldespayestleeqeeleysykdifkkywrdIIVCFTGVAFLNV 257
Cdd:COG2271 156 WL--------LAAFGWRAAFLILGLPGLLLALLR---------------------------------FWLLALAYFLVYF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 258 ANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFgLIGFSLFSVVAFWFMSIPSIPM 337
Cdd:COG2271 195 ALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 338 IIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVyNIGAAVFGGLTPFILTTLVETTGQKIAPsYYLTVINVIGL 417
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV-NTFGFLGGALGPLLVGYLLDATGYQAAF-LLLAALALLAA 351
|
410
....*....|
gi 2026912915 418 LVFVFMFKTT 427
Cdd:COG2271 352 LLALLLLRET 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-431 |
4.66e-32 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 126.15 E-value: 4.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 19 TVFATGIGNAIEWFDFGLYAQLAVIISSNFfgnmpkEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIIL 98
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 99 MACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGkLGSGLEIGtlSGNiLAAALVGI 178
Cdd:COG2223 80 LGIGLLLLALAVS--------YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG-LALGLAAG--GGN-LGAAVAAF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 179 MYALLsdeqMAAWGWRIPFIIAAP-LGIVGVYLRNNLDESPAYESTLEEQEELEYsyKDIFKKywRDIIVCFTGVAFLNV 257
Cdd:COG2223 148 LAPLL----IAAFGWRNAFLILGIlLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ--LEALRD--PRFWLLSLLYFGTFG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 258 ANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFmsIPSIPM 337
Cdd:COG2223 220 SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA--LGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 338 IIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGaAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGL 417
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAG-GLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVAL 376
|
410
....*....|....
gi 2026912915 418 LVFVFMFKTTSNKS 431
Cdd:COG2223 377 VLTLLLYRRPRRAA 390
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-404 |
1.18e-31 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 125.11 E-value: 1.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 21 FATGIGNAIEWFDFGLYAQLAVIISSNFfgnmpkEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMA 100
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEF------GLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 101 CSTLVLGLLPTQHQigiwapilLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMY 180
Cdd:cd17371 76 VFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 181 ALLSDEqmaaWGWRIPFIIAAPLGIVGVYLRNNLDESPAYESTLEEQEELEYSYK--DIF-KKYWRDIIVCFTGVAFLNV 257
Cdd:cd17371 148 PLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSlrELFsPPLLRTTLLASLLATGALG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 258 ANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFmsIPSIPM 337
Cdd:cd17371 224 GYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFL--PLSPTL 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2026912915 338 IIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVfGGLTPFILTTLVETTGQKIA 404
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSLGTA 367
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-220 |
6.06e-31 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 121.07 E-value: 6.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 12 DASKTKKTVFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPkEIQLastfaVFAFAFIVRPIGGIFFSHIGDKHGRKVV 91
Cdd:COG0477 8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSA-QLGW-----IVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 92 LSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNIL 171
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2026912915 172 AAALVGIMyallsdeqMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAY 220
Cdd:COG0477 154 GPLLGGLL--------VAALGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-384 |
3.74e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 105.96 E-value: 3.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 25 IGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQLASTFAVFAFAfivrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTL 104
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYA-----LAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 105 VLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYALls 184
Cdd:pfam07690 78 LLLFASS--------LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 185 deqmaaWGWRIPFIIAAPLGIVGVYLRNnLDESPAYESTLEEQEELEYSYKDIFKKYWRD-IIVCFTGVAFLNVANYMVL 263
Cdd:pfam07690 148 ------FGWRAAFLILAILSLLAAVLLL-LPRPPPESKRPKPAEEARLSLIVAWKALLRDpVLWLLLALLLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 264 SYMPSFLNgTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLF 343
Cdd:pfam07690 221 TYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2026912915 344 IIALFMSTFEGVMPSVLPSIFHTKVRLRTLSL---VYNIGAAVF 384
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLyntAGSLGGALG 343
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
20-432 |
1.12e-24 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 106.20 E-value: 1.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 20 VFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQ-----LASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSS 94
Cdd:pfam00083 2 ALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSslaalSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 95 TIILMACSTLVLGLLPtqhqiGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGtlsgnILAAA 174
Cdd:pfam00083 82 ANVLFVIGAVLQGAAK-----GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLA-----ITFGI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 175 LVGIMYALLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAY------------------------ESTLEEQEEL 230
Cdd:pfam00083 152 LLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrleearevlaklrgvpdvdRELDEIKDSL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 231 EYS---YKDIFKKYWRD------IIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTM--SSVLSTVTMAAMIPAVFFf 299
Cdd:pfam00083 232 EAGqeaEKASWKELFSTktrrqrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFlvTIIVGVVNFVFTFIAIFL- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 300 gwySDKVGNKNTILFGLIGFSLFSVV----AFWFMSIPSIPMIIIGLFI---IALFMSTFEGVMPSVLPSIFHTKVRLRT 372
Cdd:pfam00083 311 ---VDRFGRRPLLLLGAAGMAICFVIlgivALLGVSKSDWAGIVAIVFIalfIAFFAMGWGPVPWVIVSELFPLSVRSKA 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2026912915 373 LSL---VYNIGAAVFGGLTPFILTTLvettgqKIAPSYYL-TVINVIGLLVFVFMFKTTSNKSL 432
Cdd:pfam00083 388 MALataANWLANFLIGFLFPIITDAI------GLGYTFFIfAGLLVLFIIFVFFFVPETKGRTL 445
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-425 |
4.67e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.57 E-value: 4.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 62 FAVFAFA-FIVRPIGGIffshIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAG 140
Cdd:cd17325 37 VAAYALAqLLFSPPAGR----LSDRFGRKRLLLLGLLLLAVSTLLFAFATS--------YWQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 141 AMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYAllsdeqmaAWGWRIPFIIAAPLGIVGVYLRNNL--DESP 218
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPFLVCAALALLALVLALLLlpEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 219 AYESTLEEQEELEYSYKDIFKKywRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFF 298
Cdd:cd17325 177 PPNKRAVSAARLRSGLRLLLRD--RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 299 FGWYSDKVGNKNTILFGLIgfsLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSL--- 375
Cdd:cd17325 255 AGKLSDRIGRKPLILIGLL---LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLfnt 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2026912915 376 VYNIGAAVfgglTPFILTTLVETTGqkIAPSYYLTVINVIGLLVFVFMFK 425
Cdd:cd17325 332 AFSLGMVL----GPLLGGFLYDAFG--FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-424 |
7.63e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 94.58 E-value: 7.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 16 TKKTVFATGIGNAIEWFDFGLYAQLAVIISSNFFGNMPKEIQLASTFAVFaFAFIVRPIGGIFFSHIGDKHG-RKVVLSS 94
Cdd:COG2211 8 SLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARL-WDAITDPLIGALSDRTRTRWGrRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 95 TIILMACSTLVLGLLPTQHQIG--IWAPILLLIVRMVQSFSTggeyAGAMTYIAETSPD-KTRGKLGSGLEIGTLSGNIL 171
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLAYTLVN----IPYSALGAELTPDyEERTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 172 AAALVGIMYALLSDEQmaAWGWRIPFIIAAPLGIVGVYL-RNNLDESPAYEstlEEQEELEYSYKDIFK-KYWRDIIVCF 249
Cdd:COG2211 163 ASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLLtFFGTKERPVPE---EEKVSLKESLKALLKnRPFLLLLLAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 250 tgvAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSvVAFWF 329
Cdd:COG2211 238 ---LLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL-LLLFF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 330 MSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSI-----FHTKVRLR-----TLSLVYNIGAAVFGGLTPFILTTLVETT 399
Cdd:COG2211 314 LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydeWKTGRRREglyfgIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
410 420
....*....|....*....|....*
gi 2026912915 400 GQKIAPSYYLTVINVIGLLVFVFMF 424
Cdd:COG2211 394 GAAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
17-399 |
1.34e-20 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 93.84 E-value: 1.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 17 KKTVFATGIGNAIEWFDFGLYAQLAVIISSNFfGNMPKEIQLASTFAvfafaFIVRPIGGIFFSHIGDKHGRKVVLSSTI 96
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADL-GLTDMEGAFLATAA-----FIGRPFGGALFGLLADKFGRKPLMMWSI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 97 ILMACSTLVLGLLPTQhqigiwapILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALV 176
Cdd:PRK12307 91 VAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 177 gimyallsdEQMA-AWGWRIPFIIAAPLGIVGVYLRNNLDESPAYE---------STLEEQEELEYSYKDIFKKYWRDII 246
Cdd:PRK12307 163 ---------PSFAeAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEeaklsgkgkHSQSAWSVFSLSMKGLFNRAQFPLT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 247 VCFTGVAF-LNVANYMVLSYMPSFLNGTidlgGTMSSVLSTVTMAAMIPAV---FFFGWYSDKVGNKNTILFGLIGFSLF 322
Cdd:PRK12307 234 LCVFIVLFsIFGANWPIFGLLPTYLAGE----GFDTGVVSNLMTAAAFGTVlgnIVWGLCADRIGLKKTFSIGLLMSFLF 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2026912915 323 sVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAvfGGLTPFILTTLVETT 399
Cdd:PRK12307 310 -IFPLFRIPQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAAT--SGTFNSMAATWLGIT 383
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
18-400 |
5.16e-20 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 92.45 E-value: 5.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 18 KTVFATGIGNAIEWFDFGLYAQLAVIISSNFfgnmpkEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTII 97
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLITLVLTEVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 98 LMACSTLVLGLLPtqhqiGIWApilLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLeigtLSGNILAAALVG 177
Cdd:PRK03893 94 LFSVGTLACGFAP-----GYWT---LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL----ISGFSIGAVVAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 178 IMYALLsdeqMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYESTLEEQEELEYSYKDIFKKYWRDI------------ 245
Cdd:PRK03893 162 QVYSLV----VPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIInilltlaaaaal 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 246 IVCFTG-------VAFLNVA------NYMV---------------------------LSYMPSFLNgtIDLGGTMSSVLS 285
Cdd:PRK03893 238 WFCFAGnlqnaaiVAVLGLLcaaifiSFMVqssgkrwptgvmlmvvvlfaflyswpiQALLPTYLK--TDLGYDPHTVAN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 286 TVTMAAMIPAV--FFFGWYSDKVGNKNTILFGLIgFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSI 363
Cdd:PRK03893 316 VLFFSGFGAAVgcCVGGFLGDWLGTRKAYVCSLL-ISQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGGY 394
|
410 420 430
....*....|....*....|....*....|....*..
gi 2026912915 364 FHTKVRLRTLSLVYNIGaAVFGGLTPFILTTLVETTG 400
Cdd:PRK03893 395 FDTEQRAAGLGFTYNVG-ALGGALAPILGALIAQRLD 430
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-421 |
5.71e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.25 E-value: 5.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 24 GIGNAIEWFDFGLYAQLAVIISSNFFGNmpkEIQLASTFAVFAFAFIvrpIGGIFFSHIGDKHGRKVVLSSTIILMACST 103
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLS---ASQLGLLFALFSLGYA---LLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 104 LVLGLLPtqhqigiwAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYALL 183
Cdd:cd06174 76 LLFAFAP--------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 184 SdeqmaaWGWRIPFIIAAPLGIVGVYLRNNLDESPAYESTLEEQEELEYSYKDIFKKYWRDIIVCFTGVA--FLNVANYM 261
Cdd:cd06174 148 G------FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAifLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 262 VLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILfgLIGFSLFSVVAFWFMSIPSIPMIIIG 341
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL--LIGLLLMALGLALLLLAPSLLLLLLL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 342 LFIIALFMSTFEGVMpSVLPSIFHTKVRLRTLSLVYNIGAAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGLLVFV 421
Cdd:cd06174 300 LLLLGFGLGGLLPLS-FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
64-396 |
1.12e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 84.72 E-value: 1.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 64 VFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQigiwapilLLIVRMVQSFSTGGEYAGAMT 143
Cdd:TIGR00895 57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 144 YIAETSPDKTRGKL----GSGLEIGTLSGNILAAALVgimyallsdeqmAAWGWRIPFIIA--APLgIVGVYLRNNLDES 217
Cdd:TIGR00895 129 LVSEYAPKRFRGTAvglmFCGYPIGAAVGGFLAGWLI------------PVFGWRSLFYVGgiAPL-LLLLLLMRFLPES 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 218 PAY------------------------ESTLEEQEELEYSYKDIFK-----KYWRDIIVCFTGVAFLNVANYMVLSYMPS 268
Cdd:TIGR00895 196 IDFlvskrpetvrrivnaiapqmqaeaQSALPEQKSTQGTKRSVFKalfqgKTARITVLLWLLYFMLLVGVYFLTNWLPK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 269 FlngTIDLGG--TMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMIiigLFIIA 346
Cdd:TIGR00895 276 L---MVELGFslSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLL---GAIAG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2026912915 347 LFMSTFEGVMPSVLPSIFHTKVRLRTLSLVYNIGAAVfGGLTPFILTTLV 396
Cdd:TIGR00895 350 FFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLG-AIIGPILAGYLL 398
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-387 |
5.13e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 5.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKT 153
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS--------FALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 154 RGKLGSGLEIGTLSGNILAAALVGIMyallsdeqMAAWGWRIPFIIAAPLG-IVGVYLRNNLDESPAYESTleeQEELEY 232
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGGLL--------GQLLGWRAAFLAIAVLAlLAALLLWRLLPSLPPKKPG---SLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 233 SYKDIFKKywRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTI 312
Cdd:cd17324 190 SLLLLLRN--PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 313 LFGLigFSLFSVVAFWFmsipsIPMIIIGLFIIALFMSTFEGVMPSVLPSIF---HTKVRLRTLSL---VYNIGAAVFGG 386
Cdd:cd17324 268 IALL--LLAAALLLLTL-----LGPSPLLLLVGLVLWGLGFFAAHSALQTRVlrlAPEARGLASSLylaAYNLGGALGAA 340
|
.
gi 2026912915 387 L 387
Cdd:cd17324 341 L 341
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
51-423 |
1.83e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 68.37 E-value: 1.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 51 NMPKEIQLAST---FAVFAFaFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLlptqhqigIWAPILLLIVR 127
Cdd:cd17319 28 TIMKDLGLSPTqygLIASAF-FLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF--------ATSLTSLYVLR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 128 MVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMyallsdeqMAAWGWRIPFIIAAPLGIV- 206
Cdd:cd17319 99 FLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL--------LLLFGWRWAFIIEGLLGLLl 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 207 GVylrnnldespayestleeqeeleysykdIFKKYWRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLST 286
Cdd:cd17319 171 AV----------------------------LWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 287 VTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHT 366
Cdd:cd17319 223 IPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2026912915 367 KVRLRTLSLVyNIGAAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGLLVFVFM 423
Cdd:cd17319 303 EAAATAGGLI-NSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
74-425 |
2.04e-11 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 65.29 E-value: 2.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQigiwapilLLIVRMVQSFSTGGEYAGAMTYIAETSPDKT 153
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 154 RGKLGSGLEIGTlSGNILAAALVGIMYALlsdeqMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAyestleeqeeleys 233
Cdd:cd17315 121 RGALGTLNQLMI-TFGILLAYLLGLALSL-----SPPGWWRLMFALAAVPALLQLLLMFFLPESRA-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 234 ykdifkkywrdIIVCFTGVAFLNVA--NyMVLSYMPSFLNgtiDLGGTMSSVLST-VTMAAMIPAVFFFGWYSDKVGNKN 310
Cdd:cd17315 181 -----------LLVGVGLQLLQQLTgiN-AVMYYAPTIFK---SAGGGTASILASiIVGVVNLLATLVAIRLVDKVGRRP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 311 TILFGLIG--FSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFE---GVMPSVLPS-IFHTKVRlrtlslvyNIGAAVF 384
Cdd:cd17315 246 LLLIGFAGmaASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAmgaGPVPWLLLSeIFPLRIR--------GKGMAIA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2026912915 385 GG---LTPFILTTLVETTGQKIAPSYYLTVINVIGLLVFVFMFK 425
Cdd:cd17315 318 TLvnwIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFF 361
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
63-424 |
2.96e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.94 E-value: 2.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 63 AVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQIGIWAPILLLIVRMVQS-FSTGGEYAga 141
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaFFGPARQA-- 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 142 mtYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYALLsdeqmaawGWRIPFIIAAPLGIVGVY----LRNNLDES 217
Cdd:cd06173 116 --LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALL--------GPGGAFAINALSFLLSALlllfIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 218 PAYESTLEEQEELEYSYkdiFKKYWRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVF 297
Cdd:cd06173 186 PGESSSLLLRDLREGLR---YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 298 FFGWYSDKVGNKNTILFGLIGFSLFSVVAFWfmsIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSlVY 377
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFS-VY 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2026912915 378 NIGAAVFGGLTPFILTTLVETTGqkIAPSYYLTVINVIGLLVFVFMF 424
Cdd:cd06173 339 NALNSGAMPLGALLAGLLADALG--LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
61-422 |
2.99e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.92 E-value: 2.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 61 TFAVFAFAFIVRPIGGIffshIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAG 140
Cdd:cd17489 37 VGLFTLAALLARPFAGR----LLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 141 AMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYAllsdeqmaAWGWRIPFIIAAPLGIVGVYLRNNLdesPAY 220
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--------HLGFAVLFIVAAVLALLALLLVFLV---KDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 221 ESTLEEQEELEYSYKDIFKkyWRDIIVCFTGVAFLNVANYMVLSYMPSFLngtIDLGGTMSSVLSTVTMAAMIPAVFFFG 300
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLV--EKKVLPPALILFLASIAYGAISTFLPLYA---AERGISNAGLFFTVYAIALLLSRPFSG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 301 WYSDKVGNKNTILFGLIGFSLfSVVAFWFMSIPSIPMIIIGLFII--ALFMSTFEGVMPSVLPsifhtKVRLRTLSLVYN 378
Cdd:cd17489 249 KLSDRKGPKTVIIPGLLLLAL-GLLLLSFAGSPWMLLLAAVLYGLgfGLLFPALQALAVDLVP-----PHRRGAANGTFF 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2026912915 379 IGAAVFGGLTPFILTTLVETTGQKIApsYYLT-VINVIGLLVFVF 422
Cdd:cd17489 323 IFFDLGIGLGGLLLGLVAELFGYRAM--FLLAaVVVLLALVLYIF 365
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
74-432 |
2.61e-10 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 61.88 E-value: 2.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLSSTIILMACSTLVlgllptqhQIGIWAPILLLIV-RMVQSFSTGGEYAGAMTYIAETSPDK 152
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVIYIIGAII--------QVAAIGKWYQLIVgRIIAGLGVGFASVLVPVYQSEVAPKH 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 153 TRGKLGSGLEIGTLSGNILAAALVGIMYALLSDEQmaawgWRIPF---IIAAPLGIVGVYLrnnLDESPAYestleeqee 229
Cdd:cd17356 132 IRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLglqIVWGLLLLIGMFF---LPESPRW--------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 230 leysykdifkkYWRDIIVC-------FTGVaflNVANYmvlsYMPSFLNGTIDLGG---TMSSVLSTVTMAAMIPAVFFF 299
Cdd:cd17356 195 -----------LYRTILGImlqlfqqLTGI---NYFFY----YGTTIFQSTGLTGSsplLTSIILYIVNFVSTIPGLFFV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 300 gwysDKVGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMIIIG----------LFIIALFMSTFE---GVMPSVLPS-IFH 365
Cdd:cd17356 257 ----DKFGRRTCLLIGAAGMSICLFIYAAVGVRYLIPNPQSGtsnksagngmIVFICLFIFSFAttwGPIAWVYVAeVFP 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2026912915 366 TKVRLRTLSLvynigAAVFGGLTPFILTTLVETTGQKIAPSYYL--TVINVIGLLVFVFMFKTTSNKSL 432
Cdd:cd17356 333 LRVRSKGMAL-----ATAFNWLWNFLISFFTPFIIGSIGFKYYYifAGCNLLAFIVVFFFVPETKGLTL 396
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-423 |
3.97e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.43 E-value: 3.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 57 QLASTFAVFAFAFIV-RPIGGIffshIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigIWapiLLLIVRMVQSFSTG 135
Cdd:cd17474 35 QVGLLITAFTLPAAVlMPVAGV----LADRFGRKKVLLPGLLLFGIGGLLCGLSDS-----FA---LLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 136 GEYAGAMTYIAETSPDKTRGK----LGSGLEIGTLSGNILAAALvgimyallsdeqmAAWGWRIPFIIAAPLGIVGVYLR 211
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKamglYEAALGLGIAVGPLLGGLL-------------AAISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 212 NNLDESPayestLEEQEELEYSYKDIFKKY--WRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTM 289
Cdd:cd17474 170 LFLLPEP-----KEKAKSSSATKLRDLKKAlrGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 290 AAMIPAVFFFGWYSDK-VGNKNTILFGLIGFSLFSVVAFWFMSIPSipmiiigLFIIALFMSTFEGVMPSVLPSI----F 364
Cdd:cd17474 245 VLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLAL-------LLIAIVLFGLGLGLNLPLLTTLvtelA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2026912915 365 HTKVRLRTLSLvYNIGAAVFGGLTPFILTTLVETTGQKiAPSYYLTVINVIGLLVFVFM 423
Cdd:cd17474 318 PEEERGTASSL-YNFVRFLGQAVGPLLFGLLLEIFGLS-APFLVGAAIALAAAVLLALL 374
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
44-424 |
6.92e-10 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 60.75 E-value: 6.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 44 ISSNFFGNMPKEIQLASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPtqHQIGIWAPILL 123
Cdd:cd17364 24 ILGRLYYGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSP--GSTPLGVMGWL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 124 LIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKL----GSGLEIGTLSGNILAAALVGIMYALLSDEQM--AAWGWRIPF 197
Cdd:cd17364 102 IFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavFAMQGFGILAGAIVTLILSAIFEHPLPAGTYhhADLVWRIVL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 198 IIAAPLGIVGVYLRNNLDESPAYESTLeeqeELEYSYKDIFKKywrdiiVCFTGVAFLNVANYMVLSYMPSFLNGTIDLG 277
Cdd:cd17364 182 GLGAIPALSVLYFRKHLLGTAGTWFLL----DIAFYGQNLFQS------TIISAIGFSKTMNAYQELFNIAVGQLIIALA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 278 GTmssvlstvtmaamIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVV-AFWFMSIPSIPMIIIGLFIIALFMSTF-EGV 355
Cdd:cd17364 252 GT-------------VPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLIlAGPYDHWKISTIGFFVLYGLTFFFSNFgPNT 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 356 MPSVLPS-IFHTKVRlrtlSLVYNIGAAVfGGLTPFILTTLVETTGQKIAPSYYLTVINVIGLLVFVFMF 424
Cdd:cd17364 319 TTFIVPAeVFPARVR----STCHGISAAS-GKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTL 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
57-431 |
2.53e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 2.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 57 QLASTFAVFAFAFIvrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGG 136
Cdd:COG0738 44 QAGLLLFAFFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--------YPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 137 EYAGAMTYIAETSPDKTRGKLgSGLE----IGTLSGNILAAALVGIMYALlsdeqmaawGWRIPFIIAA--PLGIVGVYL 210
Cdd:COG0738 113 LDVAANPYVAALGPETAASRL-NLLHaffsLGALLGPLLGGLLILLGLSL---------SWHLPYLILAvlLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 211 RNNLdesPAYESTLEEQEELEYSYKDIFKKywRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMA 290
Cdd:COG0738 183 RSKL---PEIEEEEEEAAGSAASLKSLLKN--PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 291 AMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFmsiPSIPMIIIGLFIIALFMSTfegvmpsVLPSIFH----- 365
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLSL-------MFPTIFSlaldg 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2026912915 366 -TKVRLRTLSLVynIGAAVFGGLT-PFILTTLVETTGqkIAPSYYLTVINVIGLLVFVFMFKTTSNKS 431
Cdd:COG0738 328 lGKRTAAAVSAV--LIMGIVGGAIgPPLIGFLADAFG--LRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
74-432 |
2.74e-09 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 59.28 E-value: 2.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLsstiiLMACSTLVLGLLPTQHQIGIWAPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKT 153
Cdd:TIGR00879 86 IGALFAGWLSDRFGRKKSL-----LIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKAL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 154 RGKLGSGLEIGTLSGnILAAALVGIMYALLSDEQmaawGWRIPF---IIAAPLGIVGVYLrnnLDESPAY---------- 220
Cdd:TIGR00879 161 RGALTSLYQLAITFG-ILVAYGFGSGKVSLNNTL----GWRIPLglqLIPAGLLFLGLFF---LPESPRWlvgkgrveea 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 221 --------ESTLEEQEELEY--------------------SYKDIFKKY-WRDIIVCFTGVAFLNVANYMVLSYMPSFLN 271
Cdd:TIGR00879 233 rkslarlrGTSGEDKELLDElelidikrsiekrsvqpswgSLFSSTRRIrRRLFLGVVLQWFQQFTGINAIMYYSPTIFE 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 272 G---TIDLGGTMSSVLSTVTMAAMIPAVFFfgwySDKVGNKNTILFGLIGFSLFSVV---AFWFMSIPSIPMIIIG-LFI 344
Cdd:TIGR00879 313 NagvSTDHAFLVSIIVGAVNFAFTFVAIFL----VDRFGRRPLLLIGAAGMAICLFVlgiLGASFVTGSSKSSGNVaIVF 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 345 IALFMSTFE---GVMPSVLPS-IFHTKVRLRTLSL---VYNIGAAVFGGLTPFILTTLvettgqKIAPSYYL-TVINVIG 416
Cdd:TIGR00879 389 ILLFIAFFAmgwGPVPWVIVSeIFPLSLRPKGISIavaANWLANFIVGFLFPTMLESI------GVGGVFIFfGGLNVLG 462
|
410
....*....|....*.
gi 2026912915 417 LLVFVFMFKTTSNKSL 432
Cdd:TIGR00879 463 LIFVYFFLPETKGRTL 478
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-424 |
3.62e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 3.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 44 ISSNFFGNMPKEIQLASTFAVFAFAfivrpIGGIFFSHIGDKHGRKVVLSSTIILMAcstlVLGLLPtqhqigIWAP--I 121
Cdd:cd17473 25 IAQHFVPNSELLVPLLLTLPALFIA-----LFAPLAGWLADRFGRKRLLIAGLLLYG----IGGVAG------LFLDslY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 122 LLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLgSGLEIGTLS-GNILAAALVGIMyallsdeqmAAWGWRIPF--- 197
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKM-LGLQSAAMSlGGVVFLLLGGAL---------AEIGWRAPFlvy 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 198 ---IIAAPLGIVGVYLRNNLDESPAYESTLEEQEELeysykdifkkyWRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTI 274
Cdd:cd17473 160 llaLPVLILVLLFLPEPARKSKSAASPGAATAAALP-----------WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 275 DLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTIlfgLIGFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTfeg 354
Cdd:cd17473 229 GGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL---AIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL--- 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2026912915 355 VMPSVLP---SIFHTKVRLRTLSLVyniGAAVFGG--LTPFILTTLVETTGQkiaPSYYLTVINVIGLLVFVFMF 424
Cdd:cd17473 303 LLPTLNSwamSLVPPELRGRAMGIV---TSAFFLGqfLSPLVLGPLVNLTGG---LSGAFLILGVLALVLAIVLL 371
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
63-233 |
7.42e-09 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 57.82 E-value: 7.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 63 AVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQIGIWApiLLLIVRMVQSFSTGGEYAGAM 142
Cdd:TIGR00887 60 AVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 143 TYIAETSPDKTRGKLGSGL----EIGTLSGNILAAALVGIMYALL----------SDEQMAA-WGWRIPFIIAAPLGIVG 207
Cdd:TIGR00887 138 IITSEFATKKWRGAMMAAVfamqGFGILAGAIVALIVLAGFKHSLeaaadeasctGSCVPAVdYMWRILIGFGAVPALLA 217
|
170 180
....*....|....*....|....*.
gi 2026912915 208 VYLRNNLDESPAYESTLEEQEELEYS 233
Cdd:TIGR00887 218 LYFRLTIPETPRYTADVAKDVEQAAS 243
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
77-424 |
1.41e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.41 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 77 IFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGK 156
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 157 ----LGSGLEIGTLSGNILAAALVgimyallsdeqmAAWGWRIPFIIAAPLGIVGVYLrnnldespayestleeqeeley 232
Cdd:cd17321 121 alglWGAVVGIGAALGPLLGGLLL------------ELFGWRWIFLINVPIGLVALLL---------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 233 sykdiFKKYWRDIIVcftgVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTI 312
Cdd:cd17321 167 -----ARTFSGAVLA----AFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 313 LFGLIGFSLFSVVAFWFMSIPSIPMIIIGLFII----ALFMSTFEGVMPSVLPSIfHTKVRLRTLSLVYNIGAAVFGGLT 388
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLglglGLFATPLTNAALSSVPKE-KAGAASGILNTARQLGGALGVALL 316
|
330 340 350
....*....|....*....|....*....|....*.
gi 2026912915 389 PFILTTLVETTGQKIAPSYYLTVINVIGLLVFVFMF 424
Cdd:cd17321 317 GALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAF 352
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
82-433 |
1.74e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 56.21 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 82 IGDKHGRKVVLSSTIILMACSTLVLGLLPTQHqigiwapiLLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSgL 161
Cdd:cd17362 62 LIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVS-L 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 162 EIGTLSGNILAAALVGimYALLSdeqmAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYEstleeqeeleysykdifKKY 241
Cdd:cd17362 133 KELFIVLGILLGYVSG--YAFAD----VVGGWRYMYGLAAPPALLLGIGMWFLPPSPRWQ-----------------GNY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 242 WRDIIVCFTGVAFLNVANY-MVLSYMPSFLNGTIDLGG---TMSSVLSTVTMAAM-IPAVFFFgwysDKVGNKNTILFG- 315
Cdd:cd17362 190 RKPLIIGLGLVLFQQITGQpSVLYYAATIFKSAGFSAAsdaTLVSVGLGVFKLLMtIVAVLLV----DKLGRRPLLLGGv 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 316 -LIGFSLFSV-VAFWFMSIPSIPMIIIGLFIIALFMSTFE---GVMPSVLPS-IFHTKVRLRTLSL--VYNIGAAVFGGL 387
Cdd:cd17362 266 sGMVVSLFLLaAYNLFVQMGPAGLAWLSLVALLLYVGAYQisfGPISWLMVSeIFPLRVRGRAIALavLVNFGSNALVSL 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2026912915 388 TpfiLTTLVETTGqkiAPSYYL--TVINVIGLLVFVFMFKTTSNKSLR 433
Cdd:cd17362 346 A---FLPLQELIG---LPGTFLgfGVIGVLALLFIYFTVPETKGLSLE 387
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
73-393 |
2.17e-08 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 56.16 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 73 PIGGIFFSHIGDKHGRK--VVLSSTIILMacstLVLGLLPTQHQIG-----IWAPILLLIVRMVQSFSTGGEYAgamtYI 145
Cdd:pfam13347 51 PIVGHIIDRTRTRWGRRrpWLLLSAIILA----VSFILLFTPPELGraplfIWLLATYILLRIAYTFFEIPYWS----LG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 146 AETSPD-KTRGKLGSGLEIGTLSGNILAAALVGIMYALLSDEQMAAWGWRIPFIIAAPLGIVGVYL-----RNNLDESPA 219
Cdd:pfam13347 123 PELTRDyDERTSLTSYRSFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIItaagtKERVSMRSK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 220 YESTLEEQEELEYSYKDIFK-KYWRDIIVCFTGVAF-LNVANYMVLSYMPSFLNGtidlgGTMSSVLSTVTMAAMIPAVF 297
Cdd:pfam13347 203 EDTGQKEAGSLLDMLKEVFRnRAFLILLASFLLAALaMGVLNGLLLYYFRYVLGN-----GFAASAFPLVFTIGALLGIP 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 298 FFGWYSDKVGNKNTILFG-LIGFSLFsvVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLP-----SIFHTKVRLR 371
Cdd:pfam13347 278 LWPPLAKRIGKKNTYILGaLITIAGF--ALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLAdvvdyGELRTGKRRE 355
|
330 340
....*....|....*....|....*..
gi 2026912915 372 TL-----SLVYNIGAAVFGGLTPFILT 393
Cdd:pfam13347 356 GTffamwSFISKLATGVGLGVSGLLLS 382
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
55-322 |
1.96e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.04 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 55 EIQLASTFAV---FAFAFIVRPIGGIFfshiGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQigiwapilLLIVRMVQS 131
Cdd:cd17391 33 LVELWSGLAFsstFLVSAIFSPIWGRL----ADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 132 FSTgGEYAGAMTYIAETSPdktrgKLGSGLEIGTLSGNILAAALVG-IMYALLSDeqmaAWGWRIPFIIAAPLGIVGVYL 210
Cdd:cd17391 101 VFS-GYVPNATALIASQTP-----KEKSGWALGTLSTGVVAGTLIGpLLGGFLAD----LFGIRNVFFITGGLLFLAFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 211 RNNLdespAYESTLEEQEELEYSYKDIFK--KYWRDIIVCFTGVAFLNVANYMVLSYMPSFLNgtiDLGGTMSS------ 282
Cdd:cd17391 171 TLFF----VKEDFKPVEKKKMVSTKEVWNsvPNPSLLISLFVTTFIIQLANQSIEPILTLYIR---QLMGDASNlafisg 243
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2026912915 283 -VLSTVTMAAMIPAVfFFGWYSDKVGNKNTILFGLIGFSLF 322
Cdd:cd17391 244 lVFSATGVSSLLSAP-RLGKLGDRIGHHRILLGALLASALL 283
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
74-423 |
4.43e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 51.80 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQhqigiwapILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKT 153
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 154 RGKLGSGLEIGTLSGnILAAALVGIMYA-LLSDEQMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAYestleeqeeley 232
Cdd:cd17359 123 RGRLVSLNQLMIVFG-QLLAYIVNYLIAnAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------ 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 233 sykdIFKKYwRDIIVCFTGVAFL------NVANYmvlsYMPSFLngtIDLG-GTMSSVLSTVTMA-----AMIPAVFFFg 300
Cdd:cd17359 190 ----LVSKG-KPILIIGIGLAIFqqfvgiNVIFY----YGPEIF---QNAGfSENAALLQTIGIGvvnviFTIIAILLV- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 301 wysDKVGNKNTILFGLIGFSLFSVV---AFWFMSIPSIPMIIIGLFI---IALFMSTFEGVMPSVLPSIFHTKVRLRTLS 374
Cdd:cd17359 257 ---DKVGRKPLLLIGSIGMAISLLLigtAFYFAPGSQASGIVALVLIllfVAFFAMSWGPVTWVLLSEIFPNRIRGLAMG 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2026912915 375 L---VYNIGAAVFGGLTPFILTTLvettgqKIAPSYYL-TVINVIGLLVFVFM 423
Cdd:cd17359 334 IavfFLWIANFLVSLTFPILLAAF------GLAFTFLIfAVICVLAFLFVWKF 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
249-393 |
4.89e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 249 FTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFW 328
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2026912915 329 FmsiPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLV---YNIGAAVFGGLTPFILT 393
Cdd:pfam07690 82 A---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVsagFGLGAALGPLLGGLLAS 146
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-369 |
4.92e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.43 E-value: 4.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 33 DFGLY-AQLAVIISSNFFGNMpkeiqlastfavfafafivrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPT 111
Cdd:cd17365 28 DWGLSpAQLGPVGSAALFGMA---------------------IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 112 QHQIGIWapilllivRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGS----GLEIGTLSGNILAAALVGimyallsdeq 187
Cdd:cd17365 87 VLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTlmfcGYPLGAALGGFLAAALIP---------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 188 maAWGWRIPFIIAAPLGIVGVylrnnldesPAYESTLeeqeeleysykdifkKYWRDIIVCFTGVaflnvanYMVLSYMP 267
Cdd:cd17365 149 --AFGWRSVFLLGGVPPLILL---------PLLRGTL---------------LLWVTFFMGLLLV-------YLLNSWLP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 268 SFLNGTIDLGGTMSSVLSTVTMAAMIPAVfFFGWYSDKVGNKNTIL--FGLIGFSLFSVVAFWFMSIPSIPMiiigLFII 345
Cdd:cd17365 196 KLMVEAGYSLSQALTITLLLNIGGVIGSL-LLGWLADRFGPKRVLAlfFALGAVSLALLGVSPASLVLLYVL----VFLA 270
|
330 340
....*....|....*....|....
gi 2026912915 346 ALFMSTFEGVMPSVLPSIFHTKVR 369
Cdd:cd17365 271 GACVNGAQVGLYALAARFYPTEVR 294
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
74-329 |
8.27e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.09 E-value: 8.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLP-TQHQIGIWApILLLIVRMVQSFstgGEYAGAMTyIAETSPDK 152
Cdd:cd17345 53 LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPsATSSVGLMF-ILLFLNGWFQGM---GWPPSGRT-MVHWFSKK 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 153 TRGKLGSGLEIGTLSGNILAAALVGIMYALLSDEQMAAWGWrIPFIIAAPLGIVGVYLRNNLDES-----------PAYE 221
Cdd:cd17345 128 ERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFI-FPAIIAIIVAVIVLFLGKDTPESeglppieeykgDYPE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 222 STLEEQEELEYSYKDIFKKY-------WrdiIVCFTGVaFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIP 294
Cdd:cd17345 207 EADGEEEEQELSAWEIFVKYvlknkllW---YIAIANV-FVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIP 282
|
250 260 270
....*....|....*....|....*....|....*..
gi 2026912915 295 AVFFFGWYSDKVGNKNTILFGLIGFSL--FSVVAFWF 329
Cdd:cd17345 283 GTLLAGWLSDKLFKGRRAPTGIIFMILviVALIVYWL 319
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
55-347 |
4.61e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.73 E-value: 4.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 55 EIQLASTFAVFAFAFIvrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQigiwapilLLIVRMVQSFST 134
Cdd:cd17320 33 ASAVQLTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 135 GGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMyallsdeqMAAWGWRIPFIIAAPLGIV---GVYLR 211
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLL--------LLFFGWRAIFVFLALLGLLlllLVLLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 212 nnLDESPAYESTLEEQEELEYSYKDIFK--KYWRDIIVCftgvAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTM 289
Cdd:cd17320 174 --LPETLPEEKRKPLLSSLLRAYKRVLKnrRFLGYALAL----GLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNA 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 290 AAMIPAVFFFGWYSDKVGNKNTILFGLIGF--SLFSVVAFWFMSIPSIPMIIIGLFIIAL 347
Cdd:cd17320 248 IALILGSLLNGRLVRRFGPRRLLRLGLLLLlaAALVLLLAALLGGLSLWPLVAPLFLIFF 307
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
58-423 |
4.81e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.72 E-value: 4.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 58 LASTFAVFAFAfivrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGE 137
Cdd:COG2807 57 LLTTLPLLAFG-----LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS--------VALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 138 YAGAMTYIAETSPDKTrgklgsGLEIG--TLSGNILAAALVGIMYALlsdeqMAAWGWRIPFIIAAPLGIVG------VY 209
Cdd:COG2807 124 NVLLPGLIKRWFPDRV------GLMTGlyTAAMGLGAALAAGLTVPL-----AAALGWRGALAVWALLALLAlllwlpLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 210 LRNNLDESPAYESTleeqeeleysykdIFKKYWRD----IIVCFTGVAflNVANYMVLSYMPSFLngtIDLG--GTMSSV 283
Cdd:COG2807 193 RRRPAAAAAAPAAA-------------SLRSLWRSplawLLTLFFGLQ--SLLYYAVVAWLPPIL---RDAGlsAATAGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 284 LSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFmsiPSIPMIIIGLFIIALFMSTFEGVMPSVLPSI 363
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL---APGSLPWLWAVLLGLGQGGLFPLALTLIGLR 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2026912915 364 FHTKVRLRTLS-LVYNIGaAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGLLVFVFM 423
Cdd:COG2807 332 ARTPAEAAALSgMAQSVG-YLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
235-424 |
7.07e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.94 E-value: 7.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 235 KDIFKKYWRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILF 314
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 315 GLIGFSLFSvvaFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLvYNIGAAVFGGLTPFILTT 394
Cdd:COG2271 81 GLLLWGLAT---LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI-FNAGGPLGGALAPPLLGW 156
|
170 180 190
....*....|....*....|....*....|
gi 2026912915 395 LVETTGQKIApsyyLTVINVIGLLVFVFMF 424
Cdd:COG2271 157 LLAAFGWRAA----FLILGLPGLLLALLRF 182
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
73-432 |
8.87e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.96 E-value: 8.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 73 PIGGIFFSHIGDKHGRKVVLSSTIILMACSTLvlgLLPTQHQIgiwapILLLIVRMVQSFSTGGEYAGAMTYIAETSPDK 152
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWL---LIAFAKDV-----WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 153 TRGKLGSGLEIGTLSGnILAAALVGIMYAllsdeqmaawgWR-IPFIIAAPLGIVGV----------------------- 208
Cdd:cd17358 127 VRGALGSLNQLLVNIG-ILLGYVLGSFLP-----------WRtLALIGAIPPVVFLIllffipesprwlakkgreeeaek 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 209 ---YLRN----NLDESPAYESTLEEQEEL--EYSYKDIF-KKYWRDIIVCFtGVAFLN--VANYMVLSYMPSFLNgtiDL 276
Cdd:cd17358 195 slqFLRGkdadISKEAAEIQEELAELEKEakESSFSDLFqRKYLKPLVIGL-GLMLFQqlSGINAVIFYASSIFD---EA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 277 GGTMSSVLSTVTMAA-MIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVV-----AFWFMSIPSIPMIIIGLFIIALFMS 350
Cdd:cd17358 271 GSGLDPNTATIIIGVvQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLAlglyfYLQEHGALLSSVSWLPLVGLVIYII 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 351 TFE---GVMPSVLPS-IFHTKVRLRTLSLVynigaAVFGGLTPFILTTL--VETTGQKIAPSYYL-TVINVIGLLVFVFM 423
Cdd:cd17358 351 SFSiglGPLPWVIMSeIFPAKIKGLAGSLV-----TLVNWLFAFIVTKTfpFLTLAWGASGTFWIfAGICGLALVFVLLF 425
|
....*....
gi 2026912915 424 FKTTSNKSL 432
Cdd:cd17358 426 VPETKGKSL 434
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
74-327 |
9.90e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 47.70 E-value: 9.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQhqigiwapILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKT 153
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 154 RGKLGSGLEIGTLSGNILaaaLVGIMYALLSdeqmaawgWR-IPFIIAAPLGIVGVY------------LRNNLDES--- 217
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVL---LPLVAYFIPD--------WRwLQLAVSLPTFLFFLLswfvpesprwliSQGRIEEAlki 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 218 ------------PAYESTLEEQEEL-----EYSYKDIFKKYW-RDIIVCFTGVAFLNVANYMVLSYmpsflngtiDLGGT 279
Cdd:TIGR00898 283 lqriakingkklPAEVLSLSLEKDLssskkQYSFLDLFRTPNlRKTTLCLMMLWFTTAFSYYGLVL---------DLGNL 353
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2026912915 280 MSSV-LSTVTMAAM-IPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAF 327
Cdd:TIGR00898 354 GGNIyLDLFISGLVeLPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLL 403
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
154-422 |
4.83e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.67 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 154 RGKLGSGLEIGTLSGNILAAALVGIMYALLSDEQmAAWGWRIPFIIAAPLGIVGVYL-------RNNLDESPAYESTLEE 226
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGN-ASRGYFLTALIIGIIGIILLLIcffgtreRVVPPEEEKSKLPLLK 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 227 QeeleysYKDIFK-KYWRDIIVCFTgvaFLNVANYMVLSYMPSFLngTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDK 305
Cdd:cd17332 213 S------LKALLKnRPFLILLLAYL---LYFLAFNIVNTVLVYYF--KYVLGGRAELVLLLLLILSGALLALLPWPPLKK 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 306 VGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSI---FHTKVRLRTLSLVY----- 377
Cdd:cd17332 282 RFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVidyGELKTGKRREGIFYsvmtf 361
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2026912915 378 --NIGAAVFGGLTPFILTTLVETTGQKIAPSyylTVINVIGLLVFVF 422
Cdd:cd17332 362 frKLGLALAGALVGLILSLAGYVANAAAQSA---SALNGIRLLIAVL 405
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
74-400 |
5.49e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.44 E-value: 5.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPtqhqiGIWApilLLIVRMVQSFSTGGEYAGAMTYIAETSPDKT 153
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST-----SLWV---MAALWALNGIFQGMGWPPCGRTVTKWFSRSE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 154 RGKLGSGLEIGTLSGNILAAALVGIMYALLsdeqmaaWGWRIPFIIAAPLGIVG-----VYLRN--------NLDESPAY 220
Cdd:TIGR00881 117 RGTWVSFWNCSHNVGGGLLPPLVLFGIAEL-------YSWHWVFIVPGIIAIIVslicfLLLRDspqscglpPAEEMPNE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 221 ESTLE-EQEELEYSYKDIFKKYW---RDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAV 296
Cdd:TIGR00881 190 EPDGDaEKKEEELTKKQIFLQYVllnKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 297 FFFGWYSDKVGNKNTILFGLIGFSL--FSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVrLRTLS 374
Cdd:TIGR00881 270 LLAGWLSDKLFNGRRGPLAVFFMALiiVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKA-AGTAA 348
|
330 340
....*....|....*....|....*.
gi 2026912915 375 LVYNIGAAVFGGLTPFILTTLVETTG 400
Cdd:TIGR00881 349 GFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
55-220 |
5.52e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 45.33 E-value: 5.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 55 EIQLASTFAVFAFAFIvrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLlptqhQIGIWAPILLLIVRMVQSFST 134
Cdd:cd17357 48 DLLWSLIVSIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIAC 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 135 GGEYAGAMTYIAETSPDKTRGKLGSGLEIGtLSGNILAAALVGIMYALLSDEQmaawgWRIPFIIAAPLGIVGVYLRNNL 214
Cdd:cd17357 120 GLSTGFVPMYLQEISPSELRGALGSLTQIG-VTLGILLGQVFGLPSVLGTETL-----WPYLLFFPGIPALLQLAALPFF 193
|
....*.
gi 2026912915 215 DESPAY 220
Cdd:cd17357 194 PESPKF 199
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
61-422 |
9.46e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 9.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 61 TFAVFAFAFIVRPiggiFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPtqhqiGIWapiLLLIVRMVQSFSTGGEYAG 140
Cdd:cd17478 37 VSVFSITSSLLQP----LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP-----NYW---LLLLLVALAGIGSAAFHPE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 141 AMTYIAETSPdktrGKLGSGLEIGTLSGNiLAAALVGIMYALLsdeqMAAWGWRIPFIIAAPLGIVGVYLRNNLDESPAY 220
Cdd:cd17478 105 GARLASQAAG----GRRGLAMSIFSVGGN-LGFALGPLIAAAL----VALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 221 ESTLEEQEEleySYKDIFKKYWRDIIVCFTGVAFLNVANYMVLSYMPSFL---NGTIDLGGTMssvLSTVTMAAMIpAVF 297
Cdd:cd17478 176 EAKKAAAKS---SARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLvqrGYSLVFAGLL---LSLFLFAGAI-GTL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 298 FFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFmsipSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTlSLVY 377
Cdd:cd17478 249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT----PGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLAS-GLMM 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2026912915 378 NIgAAVFGGLTPFILTTLVETTGqkIAPSYYLTVINVIGLLVFVF 422
Cdd:cd17478 324 GL-SFGLGGIGAPVLGALADAFG--LESVLLILALLPLLGALLAF 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
88-352 |
9.96e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 9.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 88 RKVVLSSTIILMAcSTLVLGLLPTqhqigIWapiLLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSGLEIGTLS 167
Cdd:cd17503 61 RRLFLTALALFTL-GSLLCGLAPN-----LA---SLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 168 GNILAAALVGImyalLSDeqmaAWGWRIPFIIAAPLGIVGVYLRNNLDESpayestleeqeeleysykdIFKKywRDIIV 247
Cdd:cd17503 132 APAIGPTLGGW----LTD----NLSWRWIFYINLPIGILALLLAPLLDLR-------------------LFKD--RNFTL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 248 CFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAF 327
Cdd:cd17503 183 GLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLA 262
|
250 260
....*....|....*....|....*
gi 2026912915 328 WFMSIPSIPMIIIGLFIIALFMSTF 352
Cdd:cd17503 263 FLTPDTSLWLIILPLFIRGLGMGLV 287
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
243-322 |
1.15e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.08 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 243 RDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLF 322
Cdd:cd17471 199 RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLF 278
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
239-424 |
1.26e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 239 KKYWRDIIVCFTGVAFLNVANYMVLSYMPSFLNgTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIg 318
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKD-AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 319 fsLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIF--HTKVRLRTLSLVYNIGAAVFggltPFILTTLV 396
Cdd:COG0738 82 --LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGpeTAASRLNLLHAFFSLGALLG----PLLGGLLI 155
|
170 180
....*....|....*....|....*...
gi 2026912915 397 ETTGQKIAPSYYLTVINVIGLLVFVFMF 424
Cdd:COG0738 156 LLGLSLSWHLPYLILAVLLLLLALLFLR 183
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
276-395 |
1.26e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.09 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 276 LGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFmsipsipMIIIGLFIIALFMSTFEGV 355
Cdd:COG2807 50 LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA-------PSVALLLAGTALIGAGIAV 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2026912915 356 MPSVLPSI----FHTKVRLRT--LSLVYNIGAAVFGGLTPFILTTL 395
Cdd:COG2807 123 GNVLLPGLikrwFPDRVGLMTglYTAAMGLGAALAAGLTVPLAAAL 168
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
55-400 |
1.91e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 55 EIQLASTFAVFAFAFivrPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQIGIwapiLLLIVRMVQSfsT 134
Cdd:cd17312 37 KDDLGIIGSAFLIAY---AVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAV----LWGLNGLFQS--M 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 135 GgeYAGAMTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMyallsdeqMAAWGWRIPFIIAAPLGIVG-VYLRNN 213
Cdd:cd17312 108 G--WPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASL--------ASYYGWRAAFLVPGIVGLVVaIILFFF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 214 LDESPAYestleeqeeleysykdifkkywrdIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMI 293
Cdd:cd17312 178 LRDSPPY------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 294 PAVFFFGWYSDKVGNKNTILFGLIGFSL--FSVVAFWFMSIPSIPMIIIgLFIIALFMSTFEGVMPSVLPSIFHTKVRLR 371
Cdd:cd17312 234 AGTILAGLLSDKLFGGRRAPIAVIYMLLmtLSLALFWFFPHNKLLSIVL-LFLIGFFVGGPINLIGGAAAQDIGRKEAAG 312
|
330 340
....*....|....*....|....*....
gi 2026912915 372 TLSLVYNIGAAVFGGLTPFILTTLVETTG 400
Cdd:cd17312 313 TATGFVGLFGYLGASLAGLPLGYIIDHYG 341
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
245-383 |
2.65e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 245 IIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIgfsLFSV 324
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLL---LRAL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2026912915 325 VAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVY---NIGAAV 383
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYwaiNLGVAI 139
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
57-203 |
3.33e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.62 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 57 QLASTFAVFAFA-----FIVRPIGGIFfshiGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigIWapiLLLIVRMVQS 131
Cdd:cd17388 35 DAATHYGVLLALyalmqFIFAPILGAL----SDRFGRRPVLLLSLAGAALDYLLMAFAPT-----LW---WLYLGRIIAG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2026912915 132 FsTGGEYAGAMTYIAETSPDKTR----GKLGSGLEIGTLSGNILAAALVGImyallsdeqmaawGWRIPFIIAAPL 203
Cdd:cd17388 103 I-TGATGAVAAAYIADVTPPEQRarnfGLLGAAFGLGFIAGPALGGLLGEI-------------SPRAPFLVAAGL 164
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
58-329 |
3.46e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.64 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 58 LASTFAVFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTQHQigiwapiLLLIVRMVQSFSTGGE 137
Cdd:cd17355 37 RAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------LYLLWGLLGGGGAGTL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 138 YAGAMTYIAETSPDKTRgklgsGLEIGTLSgniLAAALVGIMYALLSDEQMAAWGWRIPFIIAAPLG-----IVGVYLRN 212
Cdd:cd17355 110 AAVAFATVAAWWFERRR-----GLALGILT---AGGGLGSLVFLPLGAALIEAFGWRTALLVLALLAllvlvPVLLLLRR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 213 NLDESPAYESTLEEQEELEYSYKDIF--KKYWRdiivCFTGVAFLNVANYMVLSYMPSFLngtIDLGGTMSSVLSTVTM- 289
Cdd:cd17355 182 RPADLALRAYDDASPASPGSTLKEALrsASFWL----LALAFFLCGFAVVGLIVHLVPYL---ADRGISPAAAAVALALi 254
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2026912915 290 -AAMIPAVFFFGWYSDKVGNKnTILFGLIGFSLFSVVAFWF 329
Cdd:cd17355 255 gLFNIVGRLLSGWLGDRYSPR-RLLAASYALRALGLALLLL 294
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-391 |
3.87e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.57 E-value: 3.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 54 KEIQLASTFAVFAFAFIvrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigIWapiLLLIVRMVQSFS 133
Cdd:cd17317 23 RDWLVALVQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS-----YE---LFLVLRFLVGVT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 134 TGGEYAGAMTYIAETSPDKTRGKLGSgleIGTLSGNIlAAALVGIMYALLSDEQMAAWGWRIPFIIAAPLgivgvylrnn 213
Cdd:cd17317 92 SAGIFTVGFVLGMEIVGPKYRSFVGI---LFGLFWAL-GYMLLALLAYLIRDWRWLQLAISLPGLLFLLL---------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 214 ldespayestleeqeeleysykdIFKKYWRDIIVCFTGvaFLNVANYMVLSYMPSFLNGTIdlggtmssVLSTVTMAAM- 292
Cdd:cd17317 158 -----------------------LWWLPRRTIIVGLIW--FVTSLVYYGLSLNSSNLGGNL--------YLNFFLSGLVe 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 293 IPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFeGVMPSVLPSIFHTKVRLRT 372
Cdd:cd17317 205 IPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAF-SVIYLYTAELYPTVVRNTG 283
|
330
....*....|....*....
gi 2026912915 373 LSLVyNIGAAVFGGLTPFI 391
Cdd:cd17317 284 VGLC-STVARVGAILAPFI 301
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
58-208 |
4.50e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 58 LASTFAVFAFafivrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFsTGGE 137
Cdd:cd17330 39 LQSSYSLGQF------LASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRN--------LWLLFLARFLDGL-TGGN 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2026912915 138 YAGAMTYIAETSPDKTRGK----LGSGLEIGTLSGNILAAALVgimyallsdeqmAAWGWRIPFIIAAPLGIVGV 208
Cdd:cd17330 104 VSVAQAYIADITDEEERAKafgiISAAFGLGFILGPALGGFLS------------TPYGYALPFLVAAALALLNL 166
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
78-424 |
4.92e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 78 FFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigIWApilLLIVRMVQSFstggeyAGAMTYIA------ETSPD 151
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN-----LPV---LIAGRALQGI------GGAVFPLAfalvreEFPPE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 152 KTRGKLG---SGLEIGTLSGNILAAALVGImyallsdeqmaaWGWRIPFIIAAPLGIVGVYLRNNLDespayestleeqe 228
Cdd:cd17504 116 RVPVAQGilsATFGIGAGIGLPLGGWIVQH------------LGWRWIFWTAAPVAVLLAALVPLID------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 229 eleysyKDIFKKywRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTM----AAMIPAVFFFGWYSD 304
Cdd:cd17504 171 ------LRLLRR--RNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLlpgaLVMLIAGPLAGRLIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 305 KVGNKNTILFGLIgFSLFSVVAFWFMSIPSIPMIIIGLFI---IALFMSTFEGVMPSVLPsIFHTKVRLRTLSLVYNIGA 381
Cdd:cd17504 243 RVGPRRVLLIGLV-ISAVGLLLLALLHSSLWALVVALLLIgigLGLAFASLPNIVVESVP-PDRTGIATGMNTVLRTIGS 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2026912915 382 AVFGGLTPFILTTLVETTGQKIAPSYY-LTVINVIGLLVFVFMF 424
Cdd:cd17504 321 AIGPAIAGAILTTYTVSITSGGVPTEGaYVLAFLIGAALALAAL 364
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
76-362 |
5.24e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.22 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 76 GIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigIWapiLLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRG 155
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPN-----FW---QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 156 K----------LGSGLeiGTLSGNILAAALVgimyallsdeqmaawGWRIPFIIAAPLGIVGVYL---------RNNLDE 216
Cdd:cd17328 123 RalgvfyfaipLGSGL--GYVVGGLVAQATG---------------GWRWAFRVTGVLGVLLAILlllfvreppRGAAEG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 217 SPAYESTLEEQEEleySYKDIFKK--YWRdIIVCFTGVAFLNVAnymvLSY-MPSFLNGTIDLGGTMSSVLST----VTM 289
Cdd:cd17328 186 GVMAKSTATSFLA---DLKALAKNpsFIL-STLGFTAVSFVTGA----LAFwAPTFFLRAFGVGDLSSADVGLifgaITC 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 290 AAMIPAVFFFGWYSDKVGNKN------TILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMS----TFEGVMPSV 359
Cdd:cd17328 258 IAGVLGVLLGGILADRLRRKTpradplVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLnwapVFAILLYVV 337
|
...
gi 2026912915 360 LPS 362
Cdd:cd17328 338 IPT 340
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
82-329 |
5.87e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.78 E-value: 5.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 82 IGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLgsgl 161
Cdd:cd17502 53 LSDLFGRKWVLLIAIVIFELGSLLCGLAPN--------MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY---- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 162 eIGTLSGNILAAALVG-IMYALLSDEqmaaWGWRIPFIIAAPLGIVGVYLrnnldespayestleeqeeleysykdifkk 240
Cdd:cd17502 121 -QGYIGAVFGIASVAGpLIGGAFTDH----LSWRWCFYINLPIGGLALAL------------------------------ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 241 yWRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFglIGFS 320
Cdd:cd17502 166 -LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIV--IGTI 242
|
....*....
gi 2026912915 321 LFSVVAFWF 329
Cdd:cd17502 243 LMSVGAGLL 251
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
63-423 |
6.41e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.78 E-value: 6.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 63 AVFAFAFIvrpIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigiwaPILLLIVRMVQSFSTGGEYAGAM 142
Cdd:cd17477 38 SAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 143 TYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYALlsdeqmaawGWRiPFIIAAPL---GIVGVYLrnnldeSPA 219
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA---------GAL-PFLIAAVLlllALVPLLL------TRR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 220 YESTLEEQEELEysykdiFKKYWRDIIVCFTGVAFLNVANYMVLSYMPSFLNGtIDLGGTMSSVLSTVTMAAMIPAVFFF 299
Cdd:cd17477 171 AAPEIEEAESIS------LRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 300 GWYSDKVGNKNTILfgLIGFSLFSVVAFWFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLR---TLSLV 376
Cdd:cd17477 244 GWLADRFDRRRVLL--GCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAanaALLLL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2026912915 377 YNIGAAVfgglTPFILTTLVETTGqkiaPSYYLTVINVIGLLVFVFM 423
Cdd:cd17477 322 YGLGSVI----GPLLAGALMDAFG----PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
192-346 |
1.06e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 192 GWRIPFIIAAPLGIVG-----VYLRNNLDESPAYESTLEEQEELEYSYKDifkkywRDIIVCFTGVAFLNVANYMVLSYM 266
Cdd:cd17475 148 GWRAAFVVAGLVSILAavlfwLFYREPPAASAATESASTLLRSLKEVLRN------RDVWLIAIAGALLVAPQFALLTFL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 267 PSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKV--GNKNTILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLFI 344
Cdd:cd17475 222 LLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLI 301
|
..
gi 2026912915 345 IA 346
Cdd:cd17475 302 LL 303
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
64-201 |
1.46e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.67 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 64 VFAFAFIVRPIGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLLPTqhqigIWApilLLIVRMVQSFsTGGEYAGAMT 143
Cdd:PRK09874 59 VFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQN-----IWQ---FLILRALLGL-LGGFVPNANA 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2026912915 144 YIAETSPdktRGKlgSGLEIGTLSGNILAAALVGIMY-ALLSDEqmaaWGWRIPFIIAA 201
Cdd:PRK09874 130 LIATQVP---RNK--SGWALGTLSTGGVSGALLGPLAgGLLADS----YGLRPVFFITA 179
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
74-424 |
2.07e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 40.17 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 74 IGGIFFSHIG----DKHGRKvvlssTIILMACSTLVLGLLPTQHQIGIWApilLLIVRMVQSFSTGGEYAGAMTYIAETS 149
Cdd:cd17435 47 IGALLASLTGgvliDRYGRR-----TAIILTSCLLVLGSLLLVCSVSYTV---LIVGRIAIGVSISLSSIATCVYIAEIA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 150 PDKTRGKLGSGLEIGTLSGnILAAALVGIMYALLSDeqmaawGWRIPFIIAAPLGIVGVYLRNNLDESPAYEstleeqee 229
Cdd:cd17435 119 PQHRRGLLVSLNELMIVIG-ILLAYISNYAFANVSN------GWKYMFGLVIPLAALQAIAMYFLPPSPRFL-------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 230 leysykdIFKKYWRD-IIVCFTGVAFLNVANY-MVLSYMPSFLNGTIDLGGTMSSVLST----VTMAAMIPAVFFFgwys 303
Cdd:cd17435 184 -------VMKDNMRArLLIGLTLVFFVQITGQpNILFYASTVLKSVGFQSNEAASLASTgvgvVKVVSTIPAIFLV---- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 304 DKVGNKntiLFGLIGFSLFSV----VAFWFMSIPSipmiiigLFIIALFmSTFEGVMPS-VLPSIFHTKVRLRTLSLV-- 376
Cdd:cd17435 253 DKVGSK---TFLCIGSSVMAVslvtMGLWLSLASL-------LVYVAAF-SIGLGPMPWlVLSEIFPGGIRGRAMALTss 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2026912915 377 YNIGAAVFGGLTPFILTTLVettgqKIAPSYYLTVINVIGLLVFVFMF 424
Cdd:cd17435 322 MNWGINLLISLTFLTVTELI-----GLPWVCFIYTAMSLASLVFVIMF 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
63-211 |
2.13e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 63 AVFAFAFIVRPIGGIFFSHIGDKHG---RKVVLSSTIILMACSTLVLGLLPTQHQIGIWAPILLLIvrmvqSFSTGGEYA 139
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILL-----GLFAIGWNG 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2026912915 140 GAMTYIAETSPdktRGKLGSGLEIGtLSGNILAAALVGIMYALLSDeqmAAWGWRIPFI-IAAPLGIVGVYLR 211
Cdd:cd17475 313 LYLTLVAESAG---PEQAGTALGLA-NTINFIGIAIGPPLFGLLVD---ATHSYAPAWLaLALLLVLAALLLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
248-452 |
3.02e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 248 CFTGVAFLNVANYMVLSYMPSFLNgTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVaf 327
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 328 wFMSIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLSLVY------NIGAAVFGGLtpfilttLVETTGQ 401
Cdd:cd17325 78 -FAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSsaiglgFLIGPLLGGL-------LADALGY 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2026912915 402 KiAPSYYLTVINVIGLLVFVFMFKTTSNKSLRGSYPNVDNKKDLHEVFENP 452
Cdd:cd17325 150 R-APFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDR 199
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
297-419 |
4.92e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.13 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 297 FFFGWYSDKVGNKNT--ILFGLIGFSLFSVVAFwfmsIPSIPMIIIGLFIIALFMSTFEGVMPSVLPSIFHTKVRLRTLS 374
Cdd:cd17353 267 PFWGWLSDKIGRKNTlsIAFLIQGVAMFLLPFI----GSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYG 342
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2026912915 375 LVYNigAAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGLLV 419
Cdd:cd17353 343 LLYT--AKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
62-422 |
5.85e-03 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 38.86 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 62 FAVFAFAFIVrpiGGIFFSHIGDKHGRKVVLSSTIILMACSTLVLGLlptqhqigIWAPILLLIVRMVQSFSTGGEYAGA 141
Cdd:TIGR00893 35 FSAFSWGYVV---GQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAF--------AGAYVSLYILRVLLGAAEAPFFPGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 142 MTYIAETSPDKTRGKLGSGLEIGTLSGNILAAALVGIMYALLSdeqmaawgWRIPFIIAAPLGIV-GVYLRNNLDESPAY 220
Cdd:TIGR00893 104 ILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFS--------WQWAFIIEGVLGIIwGVLWLKFIPDPPQK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 221 ESTLEEQEELE-------------------YSYKDIFKKywRDIIVCFTGVAFLNVANYMVLSYMPSFLNGTIDLGGTMS 281
Cdd:TIGR00893 176 AKWLTEEEKYIvvggllaeqqgkgpstpkkYQIKELLKD--RRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 282 SVLSTVTMAAMIPAVFFFGWYSDKVGNKN-----TILFGLIGFSLFSVVAFWFMSIPSIPMIIIGLFiIALFMSTFEGVM 356
Cdd:TIGR00893 254 GFMASLPGIVGFIGMILGGRLSDLLLRRGkslvfARKTAIIAGLVLSLLMFATNYVNIPYAALALVA-LGFFGLGAGAIG 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2026912915 357 PSVLPSIFHTKVRLRTLSLVYNIGaAVFGGLTPFILTTLVETTGQKIAPSYYLTVINVIGLLVFVF 422
Cdd:TIGR00893 333 WALISDNAPGNIAGLTGGLINSLG-NLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLL 397
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
299-327 |
6.00e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 6.00e-03
10 20
....*....|....*....|....*....
gi 2026912915 299 FGWYSDKVGNKNTILFGLIGFSLFSVVAF 327
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
265-326 |
6.35e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.71 E-value: 6.35e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2026912915 265 YMPSFLNGTIDLGGTMSSVLSTVT--MAAMIPAVFFFGWYSDKVGNKNTILFGLIGFSLFSVVA 326
Cdd:cd17320 18 YLPALPAIARDLGASASAVQLTLSayLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
81-324 |
6.94e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 81 HIGDKHGRKVVLSSTIILMACSTLvlgLLPTQHQIGIWApilLLIVRMVQSFSTGGEYAGAMTYIAETSPDKTRGKLGSG 160
Cdd:cd17318 78 YLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSI 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 161 LEIGTLSGNILAAALVGimyaLLSDeqmaAWGWRIPFIIAAPLGIVGVYLrnnldespayestleeqeeleysYKDIFKK 240
Cdd:cd17318 152 AYSGSQFGTVIAMPLSG----FLCE----SLGWPSIFYIFGGLGLLWCLL-----------------------WFFLVLP 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026912915 241 YWRDIIVCFTGvaflNVANYMVLSYMPSFLNGTIDLGGTMSSVLSTVTMAAMIPAVFFFGWYSDKVGNKNTI-------L 313
Cdd:cd17318 201 VWAIVVAHFGH----NWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILstttvrkL 276
|
250
....*....|.
gi 2026912915 314 FGLIGFSLFSV 324
Cdd:cd17318 277 FTSIGFLGPGV 287
|
|
| |
