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Conserved domains on  [gi|2028476629|ref|WP_211079413|]
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2OG-Fe(II) oxygenase [Priestia megaterium]

Protein Classification

2OG-Fe(II) oxygenase( domain architecture ID 10008049)

2OG-Fe(II) oxygenase belonging to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily that share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of the target substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3826 COG3826
Uncharacterized conserved protein [Function unknown];
1-237 1.44e-139

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443038  Cd Length: 237  Bit Score: 390.73  E-value: 1.44e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629   1 MSKSLEERIASLNWASLHQSLDEVGYVKLSTLLDRNECEKIINMYDQSPYFRSTTNMKRYCFGKGEYKYFQAPLPHVLHE 80
Cdd:COG3826     1 MMTAIAARIAALDWAAIAAELDEQGCALLPGLLTPEECRALAALYDDDALFRSRVVMARHGFGRGEYKYFAYPLPELVAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629  81 LRTHFYPQLATAANRWLNHLGKDTIYPADHKEFLNQCHQKEQVRSTPLILKYEEGGYNCLHQDLYGEIYFPFQVLFALNQ 160
Cdd:COG3826    81 LRTALYPRLAPIANRWNEALGIDARYPATLAEFLARCHAAGQTRPTPLLLRYGAGDYNCLHQDLYGEHVFPLQVVILLSE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2028476629 161 REKDYTGRQSVLVEQRPRAQSRGHVITLEQGEALIFPTNHRPVLGTRGYYKTTLRHGVSTITSGTRYGLGIIFHDAQ 237
Cdd:COG3826   161 PGRDFTGGEFVLTEQRPRMQSRAEVVPLRQGDAVIFATNHRPVRGTRGYYRVNMRHGVSRVRSGERHTLGIIFHDAA 237
 
Name Accession Description Interval E-value
COG3826 COG3826
Uncharacterized conserved protein [Function unknown];
1-237 1.44e-139

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443038  Cd Length: 237  Bit Score: 390.73  E-value: 1.44e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629   1 MSKSLEERIASLNWASLHQSLDEVGYVKLSTLLDRNECEKIINMYDQSPYFRSTTNMKRYCFGKGEYKYFQAPLPHVLHE 80
Cdd:COG3826     1 MMTAIAARIAALDWAAIAAELDEQGCALLPGLLTPEECRALAALYDDDALFRSRVVMARHGFGRGEYKYFAYPLPELVAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629  81 LRTHFYPQLATAANRWLNHLGKDTIYPADHKEFLNQCHQKEQVRSTPLILKYEEGGYNCLHQDLYGEIYFPFQVLFALNQ 160
Cdd:COG3826    81 LRTALYPRLAPIANRWNEALGIDARYPATLAEFLARCHAAGQTRPTPLLLRYGAGDYNCLHQDLYGEHVFPLQVVILLSE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2028476629 161 REKDYTGRQSVLVEQRPRAQSRGHVITLEQGEALIFPTNHRPVLGTRGYYKTTLRHGVSTITSGTRYGLGIIFHDAQ 237
Cdd:COG3826   161 PGRDFTGGEFVLTEQRPRMQSRAEVVPLRQGDAVIFATNHRPVRGTRGYYRVNMRHGVSRVRSGERHTLGIIFHDAA 237
Oxygenase-NA pfam09859
Oxygenase, catalysing oxidative methylation of damaged DNA; This family of bacterial sequences ...
 65-236 3.43e-107

Oxygenase, catalysing oxidative methylation of damaged DNA; This family of bacterial sequences is predicted to catalyze oxidative de-methylation of damaged bases in DNA.


Pssm-ID: 430885  Cd Length: 172  Bit Score: 306.02  E-value: 3.43e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629  65 GEYKYFQAPLPHVLHELRTHFYPQLATAANRWLNHLGKDTIYPADHKEFLNQCHQKEQVRSTPLILKYEEGGYNCLHQDL 144
Cdd:pfam09859   1 GEYKYFAYPLPPLVAALREALYPRLAPIANRWNERLGIDARYPDTLAEFLARCHAAGQTRPTPLLLRYGPGDYNCLHQDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629 145 YGEIYFPFQVLFALNQREKDYTGRQSVLVEQRPRAQSRGHVITLEQGEALIFPTNHRPVLGTRGYYKTTLRHGVSTITSG 224
Cdd:pfam09859  81 YGELVFPLQVVILLSEPGRDFTGGEFVLTEQRPRAQSRAEVVPLRQGDALIFTTRDRPVQGTRGYYRVNMRHGVSRVRSG 160

                         170
                  ....*....|..
gi 2028476629 225 TRYGLGIIFHDA 236
Cdd:pfam09859 161 RRHTLGIIFHDA 172
 
Name Accession Description Interval E-value
COG3826 COG3826
Uncharacterized conserved protein [Function unknown];
1-237 1.44e-139

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443038  Cd Length: 237  Bit Score: 390.73  E-value: 1.44e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629   1 MSKSLEERIASLNWASLHQSLDEVGYVKLSTLLDRNECEKIINMYDQSPYFRSTTNMKRYCFGKGEYKYFQAPLPHVLHE 80
Cdd:COG3826     1 MMTAIAARIAALDWAAIAAELDEQGCALLPGLLTPEECRALAALYDDDALFRSRVVMARHGFGRGEYKYFAYPLPELVAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629  81 LRTHFYPQLATAANRWLNHLGKDTIYPADHKEFLNQCHQKEQVRSTPLILKYEEGGYNCLHQDLYGEIYFPFQVLFALNQ 160
Cdd:COG3826    81 LRTALYPRLAPIANRWNEALGIDARYPATLAEFLARCHAAGQTRPTPLLLRYGAGDYNCLHQDLYGEHVFPLQVVILLSE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2028476629 161 REKDYTGRQSVLVEQRPRAQSRGHVITLEQGEALIFPTNHRPVLGTRGYYKTTLRHGVSTITSGTRYGLGIIFHDAQ 237
Cdd:COG3826   161 PGRDFTGGEFVLTEQRPRMQSRAEVVPLRQGDAVIFATNHRPVRGTRGYYRVNMRHGVSRVRSGERHTLGIIFHDAA 237
Oxygenase-NA pfam09859
Oxygenase, catalysing oxidative methylation of damaged DNA; This family of bacterial sequences ...
 65-236 3.43e-107

Oxygenase, catalysing oxidative methylation of damaged DNA; This family of bacterial sequences is predicted to catalyze oxidative de-methylation of damaged bases in DNA.


Pssm-ID: 430885  Cd Length: 172  Bit Score: 306.02  E-value: 3.43e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629  65 GEYKYFQAPLPHVLHELRTHFYPQLATAANRWLNHLGKDTIYPADHKEFLNQCHQKEQVRSTPLILKYEEGGYNCLHQDL 144
Cdd:pfam09859   1 GEYKYFAYPLPPLVAALREALYPRLAPIANRWNERLGIDARYPDTLAEFLARCHAAGQTRPTPLLLRYGPGDYNCLHQDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028476629 145 YGEIYFPFQVLFALNQREKDYTGRQSVLVEQRPRAQSRGHVITLEQGEALIFPTNHRPVLGTRGYYKTTLRHGVSTITSG 224
Cdd:pfam09859  81 YGELVFPLQVVILLSEPGRDFTGGEFVLTEQRPRAQSRAEVVPLRQGDALIFTTRDRPVQGTRGYYRVNMRHGVSRVRSG 160

                         170
                  ....*....|..
gi 2028476629 225 TRYGLGIIFHDA 236
Cdd:pfam09859 161 RRHTLGIIFHDA 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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