NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2034439061|ref|WP_211385670|]
View 

autotransporter outer membrane beta-barrel domain-containing protein, partial [Agrobacterium tumefaciens]

Protein Classification

AidA family protein( domain architecture ID 11465954)

AidA family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 3-869 2.20e-89

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 301.87  E-value: 2.20e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061   3 NSGTISGGRGGTTSPASEGLATGNGGAGGHGINGSDVTILNSGTVAGAQGGLGGILNWNIAGQGGDGIHGDRLSVTNAGI 82
Cdd:COG3468    15 GGTGGGGGLGGTGGGNAGLGIGNGGGGGAASGSGAGGVAGNGGGGGGGAGGGGGGAGSGGGLAGAGSGGTGGNSTGGGGG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  83 ISGGVGGDGSVYFSGSGPAGTGGAGIAGNDLMIVNTGmIAGGKTGAGEPGNYHIQGGPGIRGDRLTISNEAGGTISGGAG 162
Cdd:COG3468    95 NSGTGGTGGGGGGGGSGNGGGGGGGGGGGGTGGGGGG-GTGSAGGGGGGGGGGTGVGGTGAAAAGGGTGSGGGGSGGGGG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 163 KDIPDGWYPIGDGEGISGSDVTIFNAGGITGPKQAITFRGGTNRLELHSGWSILGTVEGYGESNTLALGGVANGTFDSSR 242
Cdd:COG3468   174 AGGGGGGGAGGSGGAGSTGSGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 243 LSGYNHPAGGFYAFGRFEKTGSSTWSLTESTRSYTPWRILEGTLRISSNEALGFENGSLTLANGATLetaasmrmdrevf 322
Cdd:COG3468   254 TGGGAAGTGGGGGGTGTGSGGGGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGS------------- 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 323 leAGGGTFQVASSTTLELAGAVGGVGGLVKAGEGALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSAHSVAANTTLDLN 402
Cdd:COG3468   321 --NAGGGSGGGGGGGGGGGGGGTTLNGAGSAGGGTGAALAGTGGSGSGGGGGGGSGGGGGAGGGGANTGSDGVGTGLTTG 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 403 GFSQTLGSLDNRGRVAFGSNPGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRD 482
Cdd:COG3468   399 GTGNNGGGGVGGGGGGGLTLTGGTLTVNGNYTGNNGTLVLNTVLGDDNSPTDRLVVNGNTSGTTGVRVNNAGGLGAQTVN 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 483 GIKVIDVAGASNGKFTLVGdyslrgqpTIAAGAYGYQLHKGNAT-NAGDWYLRSQRLaelpvnddmpepgsdqdpvsnsN 561
Cdd:COG3468   479 GIEVVEVNGASDGAFTLGG--------RVVAGAYEYTLYQGGSGgDDGNWYLRSTLT----------------------P 528

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 562 PAPAKPLYQAGVPLYETYARTLLGMNGLPTLQQRVGTRSWNTGSDSAPPkGIWSRtnVSNTSFDQRTSVSGASYSLSTSN 641
Cdd:COG3468   529 PDPPTPVYRPEVPSYLANPAAANGLFELGTLHDRLGERRYTDTGESDNS-GAWLR--VEGGHNRSRDSSGQLDYDSNRYG 605

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 642 FQAGLDGEMASNSAGSLVAGISVHYGRSSADIISIY-GDGDINTDGYGFGSAVTWYGENGLYVDGQAQATWFDSDLSSRT 720
Cdd:COG3468   606 LQLGGDLLQWEDGGGRLHVGVMAGYGNGDSDVRSRAtGTGKGDVDGYSLGLYGTWYGNNGFYVDGVLQYSWFDNDVSSDD 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 721 ASRnMASNNRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLTGRLGISLDYRSSWSD 800
Cdd:COG3468   686 LGG-VTGSYDGNGYSASLEAGYPFKLGEGWSLEPQAQLIYQGVDFDDFTDSNGTRVSGDDGDSLQGRLGLRLGYEFHWDD 764

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2034439061 801 DsgriSSTRIYGITNLFYEFLDGTQTTVSGTPFASVHDRLWADVGFGGSFDWDDgKYSLYGEASVATDL 869
Cdd:COG3468   765 G----RALQPYLEANWLHEFLGDNSVTVNGVSFSQDGSGTWGELGLGVTGQLNK-NLSLYGDVGYQTGL 828
 
Name Accession Description Interval E-value
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 3-869 2.20e-89

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 301.87  E-value: 2.20e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061   3 NSGTISGGRGGTTSPASEGLATGNGGAGGHGINGSDVTILNSGTVAGAQGGLGGILNWNIAGQGGDGIHGDRLSVTNAGI 82
Cdd:COG3468    15 GGTGGGGGLGGTGGGNAGLGIGNGGGGGAASGSGAGGVAGNGGGGGGGAGGGGGGAGSGGGLAGAGSGGTGGNSTGGGGG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  83 ISGGVGGDGSVYFSGSGPAGTGGAGIAGNDLMIVNTGmIAGGKTGAGEPGNYHIQGGPGIRGDRLTISNEAGGTISGGAG 162
Cdd:COG3468    95 NSGTGGTGGGGGGGGSGNGGGGGGGGGGGGTGGGGGG-GTGSAGGGGGGGGGGTGVGGTGAAAAGGGTGSGGGGSGGGGG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 163 KDIPDGWYPIGDGEGISGSDVTIFNAGGITGPKQAITFRGGTNRLELHSGWSILGTVEGYGESNTLALGGVANGTFDSSR 242
Cdd:COG3468   174 AGGGGGGGAGGSGGAGSTGSGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 243 LSGYNHPAGGFYAFGRFEKTGSSTWSLTESTRSYTPWRILEGTLRISSNEALGFENGSLTLANGATLetaasmrmdrevf 322
Cdd:COG3468   254 TGGGAAGTGGGGGGTGTGSGGGGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGS------------- 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 323 leAGGGTFQVASSTTLELAGAVGGVGGLVKAGEGALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSAHSVAANTTLDLN 402
Cdd:COG3468   321 --NAGGGSGGGGGGGGGGGGGGTTLNGAGSAGGGTGAALAGTGGSGSGGGGGGGSGGGGGAGGGGANTGSDGVGTGLTTG 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 403 GFSQTLGSLDNRGRVAFGSNPGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRD 482
Cdd:COG3468   399 GTGNNGGGGVGGGGGGGLTLTGGTLTVNGNYTGNNGTLVLNTVLGDDNSPTDRLVVNGNTSGTTGVRVNNAGGLGAQTVN 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 483 GIKVIDVAGASNGKFTLVGdyslrgqpTIAAGAYGYQLHKGNAT-NAGDWYLRSQRLaelpvnddmpepgsdqdpvsnsN 561
Cdd:COG3468   479 GIEVVEVNGASDGAFTLGG--------RVVAGAYEYTLYQGGSGgDDGNWYLRSTLT----------------------P 528

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 562 PAPAKPLYQAGVPLYETYARTLLGMNGLPTLQQRVGTRSWNTGSDSAPPkGIWSRtnVSNTSFDQRTSVSGASYSLSTSN 641
Cdd:COG3468   529 PDPPTPVYRPEVPSYLANPAAANGLFELGTLHDRLGERRYTDTGESDNS-GAWLR--VEGGHNRSRDSSGQLDYDSNRYG 605

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 642 FQAGLDGEMASNSAGSLVAGISVHYGRSSADIISIY-GDGDINTDGYGFGSAVTWYGENGLYVDGQAQATWFDSDLSSRT 720
Cdd:COG3468   606 LQLGGDLLQWEDGGGRLHVGVMAGYGNGDSDVRSRAtGTGKGDVDGYSLGLYGTWYGNNGFYVDGVLQYSWFDNDVSSDD 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 721 ASRnMASNNRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLTGRLGISLDYRSSWSD 800
Cdd:COG3468   686 LGG-VTGSYDGNGYSASLEAGYPFKLGEGWSLEPQAQLIYQGVDFDDFTDSNGTRVSGDDGDSLQGRLGLRLGYEFHWDD 764

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2034439061 801 DsgriSSTRIYGITNLFYEFLDGTQTTVSGTPFASVHDRLWADVGFGGSFDWDDgKYSLYGEASVATDL 869
Cdd:COG3468   765 G----RALQPYLEANWLHEFLGDNSVTVNGVSFSQDGSGTWGELGLGVTGQLNK-NLSLYGDVGYQTGL 828
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 420-868 4.06e-80

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 265.40  E-value: 4.06e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 420 GSNPGTVLTVSGNLTGHdGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAGASNGKFTL 499
Cdd:TIGR01414   1 PGGAFNTLTVNGLYTGN-GGFVMNTDLGGDNSQTDRLVVNGNASGTTGVVVNNIGGEGAQTGDGITLVTVNGGSDAAFTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 500 VGDYslrgqptIAAGAYGYQLHKGNATNAGDWYLRSQrlaelpvnddMPEPGSDQDPVSnsnpapakPLYQAGVPLYETY 579
Cdd:TIGR01414  80 ANGK-------VDAGAYTYTLYKNGTEDNNNWYLTSS----------LPDLTPPGQQLS--------PTYRAEAGSYAAN 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 580 ARTLLGMNGLPTLQQRVGTRSWNTGSdsaPPKGIWSRTNVSNTSFDQRTSvsGASYSLSTSNFQAGLDGEMASNSAGSLV 659
Cdd:TIGR01414 135 ANAALFLAELDTLRQRMGDLRSAARD---AGNGVWARIFGGDNHLDGDAG--AAGYDQNTTGVQLGGDILLAGNADGDLH 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 660 AGISVHYGRSSADIISIYGDGDINTDGYGFGSAVTWYGENGLYVDGQAQATWFDSDLSSRTASRNMASNNRGFGYTLGLE 739
Cdd:TIGR01414 210 VGLMAGYAKADIKTRSYKYGGKGKVDGYGLGLYGTWLQDSGAYVDGVLQYSRFRNDVSSTGSNGKVSGKYNSNGFTASLE 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 740 TGARMDIAP-AWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLTGRLGISLDYRSSWSddSGRISstRIYGITNLFY 818
Cdd:TIGR01414 290 AGYRYNLGGnGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGGGDSLQGRLGLRVGYQFDLG--TGRAV--KPYLKANVLH 365

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2034439061 819 EFLDGTQTTVSGTPFASVHDRLWADVGFGGSFDWDDgKYSLYGEASVATD 868
Cdd:TIGR01414 366 EFKGGTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKD-NLSLYADVDYQKG 414
PL2_Passenger_AT cd01344
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of ...
 356-536 1.28e-36

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43, AIDA-1 and IcsA, as well as, the less characterized ShdA, MisL, and BapA autotransporters.


Pssm-ID: 238654 [Multi-domain]  Cd Length: 188  Bit Score: 136.28  E-value: 1.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 356 GALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSAHSVAANTTLDLNgfsqtLGSLDNRGRVAF--GSNPGTVLTVSGNL 433
Cdd:cd01344    13 GDLTLGGGALTLTTSLTLTGTLLTGGAGTLTLDSTSTWNITGTSTLN-----VGNLTNAGTIDLgnGSPAGGTLTITGNY 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 434 TGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAG-ASNGKFTLVGdyslrgqpTIA 512
Cdd:cd01344    88 TGNGGTLRLNTVLGDDDSPTDRLVIDGDASGTTRVAVNNAGGSGATTGNGIEVVEVGGtSSNGAFSLAG--------RVV 159

                         170       180
                  ....*....|....*....|....*
gi 2034439061 513 AGAYGYQLHKGNA-TNAGDWYLRSQ 536
Cdd:cd01344   160 AGAYEYRLYRGGVsGNDGNWYLRSE 184
PRK14849 PRK14849
autotransporter barrel domain-containing lipoprotein;
409-804 2.65e-31

autotransporter barrel domain-containing lipoprotein;


Pssm-ID: 184851 [Multi-domain]  Cd Length: 1806  Bit Score: 132.94  E-value: 2.65e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  409 GSLDNRGRVAF---GSNPGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIK 485
Cdd:PRK14849  1331 GNLENGGTVQMnseGGKPGNVLTVNGNYTGNNGLMTFNATLGGDNSPTDKMNVKGDTQGNTRVRVDNIGGVGAQTVNGIE 1410

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  486 VIDVAGASNGKFTLVgdyslrgQPTIAAGAYGYQLHKGNATNAGDWYLRSQRLAELPvnDDMPEPGSDQDPVSNSNPAPA 565
Cdd:PRK14849  1411 LIEVGGNSAGNFALT-------TGTVEAGAYVYTLAKGKGNDEKNWYLTSKWDGVTP--PDTPDPINNPPVVDPEGPSVY 1481

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  566 KPlyQAGvplyeTYARTLLGMNGLPT--LQQRVGTRSWntgSDSAPPKGIWSRTNVSNTSFDQRTSVSGASYSLSTSNFQ 643
Cdd:PRK14849  1482 RP--EAG-----SYISNIAAANSLFShrLHDRLGEPQY---IDSLHSQGSASSMWMRHVGGHERSRAGDGQLNTQANRYV 1551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  644 AGLDGEMASNSAGS-------LVAGISVHYGRSSADIISIYGDGDINtdGYGFGSAVTWY----GENGLYVDGQAQATWF 712
Cdd:PRK14849  1552 LQLGGDLAQWSSNAqdrwhlgVMAGYANQHSNTQSNRVGYKSDGRIS--GYSAGLYATWYqndaNKTGAYVDSWALYNWF 1629

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  713 DSDLSSRTASRN-------MASNNRGFGYTLGLETGARmDIAPAWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLT 785
Cdd:PRK14849  1630 DNSVSSDNRSADdydsrgvTASVEGGYTFEAGTFSGSE-GTLNTWYVQPQAQITWMGVKDSDHTRKDGTRIETEGDGNVQ 1708

                          410
                   ....*....|....*....
gi 2034439061  786 GRLGISLDYRSSWSDDSGR 804
Cdd:PRK14849  1709 TRLGVKTYLNSHHQRDDGK 1727
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 613-864 6.71e-30

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 119.41  E-value: 6.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 613 IWSRTNVSNTSFDQRTSVSGasYSLSTSNFQAGLDGEMASNsagsLVAGISVHYGRSSADIISiyGDGDINTDGYGFGSA 692
Cdd:pfam03797   1 VWARGFGGRGKQDGDGGAAG--YDADTGGLQVGADYRLGDN----LRLGVAFGYSRSDADVDG--RGGSGDSDSYSLGLY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 693 VTWYGENGLYVDGQAQATWFDSDLSSRTA----SRNMASNNRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSF 768
Cdd:pfam03797  73 GTYYGDGGWYLDGGLGYGWHDNDTRRSVDlggfSETAKGDYDGNGFGASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 769 TD---PFGARVSLDDGDSLTGRLGISLDYRSSWSDdsgriSSTRIYGITNLFYEFLDGTQTTVSGTPFASVH-------- 837
Cdd:pfam03797 153 TEsggAAALSVDSQSYDSLTGRLGLRLSYTFDLGG-----GTLTPYARLGWRHEFGDDDPVTTAAFAGLSGAgsftvaga 227

                         250       260
                  ....*....|....*....|....*....
gi 2034439061 838 --DRLWADVGFGGSFDWDDGkYSLYGEAS 864
Cdd:pfam03797 228 dlARDSLELGAGLSAQLSDN-LSLYANYD 255
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 620-864 1.34e-26

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 109.97  E-value: 1.34e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  620 SNTSFDQRTSVSGASYSLSTSNFQAGLDGEMASNsaGSLVAGISVHYGRSSADIISIYGDGDINTDGYGFGSAVTWYGEN 699
Cdd:smart00869   6 GFLRQDSSGSGGSAGFDYDSYGLQLGADYRLSDN--GNLSLGFAAGYGNSKVDFSGNKGSGKGDVDSYGLGLYAGYSLGN 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  700 GLYVDGQAQATWFDSDLSSRTA---SRNMASNNRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSFT----DPF 772
Cdd:smart00869  84 GLYLDAQLGYGRSDNDTKRKVTlggAGRAKGSYDGTGYGASLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTesggGAF 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  773 GARVSLDDGDSLTGRLGISLDYRSSWSDDsgriSSTRIYGITNLFYEFLDGTQTTV--------SGTPFASVHDRLWADV 844
Cdd:smart00869 164 GLSVDSQSLDSLSLPLGLRLEYRLALGDG----ATLTPYLRLAYVHDFYDDNPVVTasllgsgaSFTTSGTDLDRNAAEL 239

                          250       260
                   ....*....|....*....|
gi 2034439061  845 GFGGSFDWDDGkYSLYGEAS 864
Cdd:smart00869 240 GLGLSAKLSNG-LSLSLNYD 258
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
409-804 5.61e-09

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 60.06  E-value: 5.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  409 GSLDNRGRVAFGSNPGTVLTVSGNL------------------------TGHDGTIL-LNASLGGDDSPADMVNVGGDTA 463
Cdd:NF033176   809 GNITNDADLSFGTAKLLSATVNGSLvnnkniilnptkesagntltvsnyTGTPGSVIsLGGVLEGDNSLTDRLVVKGNTS 888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  464 GSSILKVTNVGGLGDLTRDGIKVIDVAGASNGKFTLvgdyslrgQPTIAAGAYGYQLHKGN--ATNAGDWYLRSQrlaeL 541
Cdd:NF033176   889 GQSDIVYVNEGGSGGQTIEGINIISVEGNSDAEFSL--------KNRVVAGAYDYTLQKGNvsGTDKKGWYLTSH----L 956

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  542 PVNDD---MPEPGSdqdpvSNSNPAPAKPLYqagvplyetyartLLGMNGlptlQQRVGTRSWNTGSDSAppkGIWSRTN 618
Cdd:NF033176   957 PTSDTrqyRPENGS-----YATNMALANSLF-------------LMDLNE----RKQFSAVNDNTQPESA---SVWMKIT 1011

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  619 VSNTSfdqrTSVSGASYSLSTSNFQAGLDGEMASNSA---GSLVAGISVHYGRSSADIISIYGD-GDINT-DGYGFGSAV 693
Cdd:NF033176  1012 GGRTS----GKLSDGQNKTTTNQFINQLGGDIYKYHAeklGDFTLGIMGGYANAKGKTINHTSKkGARNTlDGYSAGLYG 1087

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  694 TWY----GENGLYVDGQAQATWFDS-----DLSSRTASRNMASNNRGFGYTLGLET-GARMDIAPAWSLTPQAQLAYSRA 763
Cdd:NF033176  1088 TWYqngaNATGLFAETWMQYNWFNAsvkgdGLEEEKYNLNGLTASVGGGYNLNVHTwTSPEGIKGEFWLQPHLQAVWMGV 1167

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2034439061  764 SFDSFTDPFGARVSLDDGDSLTGRLGI--SLDYRSSWSDDSGR 804
Cdd:NF033176  1168 TPDTHQEDNGTVVQGTGKNNLQTKAGIraSWKVKSSLDKDTGR 1210
 
Name Accession Description Interval E-value
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 3-869 2.20e-89

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 301.87  E-value: 2.20e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061   3 NSGTISGGRGGTTSPASEGLATGNGGAGGHGINGSDVTILNSGTVAGAQGGLGGILNWNIAGQGGDGIHGDRLSVTNAGI 82
Cdd:COG3468    15 GGTGGGGGLGGTGGGNAGLGIGNGGGGGAASGSGAGGVAGNGGGGGGGAGGGGGGAGSGGGLAGAGSGGTGGNSTGGGGG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  83 ISGGVGGDGSVYFSGSGPAGTGGAGIAGNDLMIVNTGmIAGGKTGAGEPGNYHIQGGPGIRGDRLTISNEAGGTISGGAG 162
Cdd:COG3468    95 NSGTGGTGGGGGGGGSGNGGGGGGGGGGGGTGGGGGG-GTGSAGGGGGGGGGGTGVGGTGAAAAGGGTGSGGGGSGGGGG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 163 KDIPDGWYPIGDGEGISGSDVTIFNAGGITGPKQAITFRGGTNRLELHSGWSILGTVEGYGESNTLALGGVANGTFDSSR 242
Cdd:COG3468   174 AGGGGGGGAGGSGGAGSTGSGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 243 LSGYNHPAGGFYAFGRFEKTGSSTWSLTESTRSYTPWRILEGTLRISSNEALGFENGSLTLANGATLetaasmrmdrevf 322
Cdd:COG3468   254 TGGGAAGTGGGGGGTGTGSGGGGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGS------------- 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 323 leAGGGTFQVASSTTLELAGAVGGVGGLVKAGEGALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSAHSVAANTTLDLN 402
Cdd:COG3468   321 --NAGGGSGGGGGGGGGGGGGGTTLNGAGSAGGGTGAALAGTGGSGSGGGGGGGSGGGGGAGGGGANTGSDGVGTGLTTG 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 403 GFSQTLGSLDNRGRVAFGSNPGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRD 482
Cdd:COG3468   399 GTGNNGGGGVGGGGGGGLTLTGGTLTVNGNYTGNNGTLVLNTVLGDDNSPTDRLVVNGNTSGTTGVRVNNAGGLGAQTVN 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 483 GIKVIDVAGASNGKFTLVGdyslrgqpTIAAGAYGYQLHKGNAT-NAGDWYLRSQRLaelpvnddmpepgsdqdpvsnsN 561
Cdd:COG3468   479 GIEVVEVNGASDGAFTLGG--------RVVAGAYEYTLYQGGSGgDDGNWYLRSTLT----------------------P 528

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 562 PAPAKPLYQAGVPLYETYARTLLGMNGLPTLQQRVGTRSWNTGSDSAPPkGIWSRtnVSNTSFDQRTSVSGASYSLSTSN 641
Cdd:COG3468   529 PDPPTPVYRPEVPSYLANPAAANGLFELGTLHDRLGERRYTDTGESDNS-GAWLR--VEGGHNRSRDSSGQLDYDSNRYG 605

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 642 FQAGLDGEMASNSAGSLVAGISVHYGRSSADIISIY-GDGDINTDGYGFGSAVTWYGENGLYVDGQAQATWFDSDLSSRT 720
Cdd:COG3468   606 LQLGGDLLQWEDGGGRLHVGVMAGYGNGDSDVRSRAtGTGKGDVDGYSLGLYGTWYGNNGFYVDGVLQYSWFDNDVSSDD 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 721 ASRnMASNNRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLTGRLGISLDYRSSWSD 800
Cdd:COG3468   686 LGG-VTGSYDGNGYSASLEAGYPFKLGEGWSLEPQAQLIYQGVDFDDFTDSNGTRVSGDDGDSLQGRLGLRLGYEFHWDD 764

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2034439061 801 DsgriSSTRIYGITNLFYEFLDGTQTTVSGTPFASVHDRLWADVGFGGSFDWDDgKYSLYGEASVATDL 869
Cdd:COG3468   765 G----RALQPYLEANWLHEFLGDNSVTVNGVSFSQDGSGTWGELGLGVTGQLNK-NLSLYGDVGYQTGL 828
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 420-868 4.06e-80

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 265.40  E-value: 4.06e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 420 GSNPGTVLTVSGNLTGHdGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAGASNGKFTL 499
Cdd:TIGR01414   1 PGGAFNTLTVNGLYTGN-GGFVMNTDLGGDNSQTDRLVVNGNASGTTGVVVNNIGGEGAQTGDGITLVTVNGGSDAAFTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 500 VGDYslrgqptIAAGAYGYQLHKGNATNAGDWYLRSQrlaelpvnddMPEPGSDQDPVSnsnpapakPLYQAGVPLYETY 579
Cdd:TIGR01414  80 ANGK-------VDAGAYTYTLYKNGTEDNNNWYLTSS----------LPDLTPPGQQLS--------PTYRAEAGSYAAN 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 580 ARTLLGMNGLPTLQQRVGTRSWNTGSdsaPPKGIWSRTNVSNTSFDQRTSvsGASYSLSTSNFQAGLDGEMASNSAGSLV 659
Cdd:TIGR01414 135 ANAALFLAELDTLRQRMGDLRSAARD---AGNGVWARIFGGDNHLDGDAG--AAGYDQNTTGVQLGGDILLAGNADGDLH 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 660 AGISVHYGRSSADIISIYGDGDINTDGYGFGSAVTWYGENGLYVDGQAQATWFDSDLSSRTASRNMASNNRGFGYTLGLE 739
Cdd:TIGR01414 210 VGLMAGYAKADIKTRSYKYGGKGKVDGYGLGLYGTWLQDSGAYVDGVLQYSRFRNDVSSTGSNGKVSGKYNSNGFTASLE 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 740 TGARMDIAP-AWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLTGRLGISLDYRSSWSddSGRISstRIYGITNLFY 818
Cdd:TIGR01414 290 AGYRYNLGGnGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGGGDSLQGRLGLRVGYQFDLG--TGRAV--KPYLKANVLH 365

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2034439061 819 EFLDGTQTTVSGTPFASVHDRLWADVGFGGSFDWDDgKYSLYGEASVATD 868
Cdd:TIGR01414 366 EFKGGTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKD-NLSLYADVDYQKG 414
PL2_Passenger_AT cd01344
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of ...
 356-536 1.28e-36

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43, AIDA-1 and IcsA, as well as, the less characterized ShdA, MisL, and BapA autotransporters.


Pssm-ID: 238654 [Multi-domain]  Cd Length: 188  Bit Score: 136.28  E-value: 1.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 356 GALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSAHSVAANTTLDLNgfsqtLGSLDNRGRVAF--GSNPGTVLTVSGNL 433
Cdd:cd01344    13 GDLTLGGGALTLTTSLTLTGTLLTGGAGTLTLDSTSTWNITGTSTLN-----VGNLTNAGTIDLgnGSPAGGTLTITGNY 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 434 TGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAG-ASNGKFTLVGdyslrgqpTIA 512
Cdd:cd01344    88 TGNGGTLRLNTVLGDDDSPTDRLVIDGDASGTTRVAVNNAGGSGATTGNGIEVVEVGGtSSNGAFSLAG--------RVV 159

                         170       180
                  ....*....|....*....|....*
gi 2034439061 513 AGAYGYQLHKGNA-TNAGDWYLRSQ 536
Cdd:cd01344   160 AGAYEYRLYRGGVsGNDGNWYLRSE 184
PL_Passenger_AT cd00253
Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V ...
 361-536 1.55e-31

Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain of autotransporters forms a pore in the outer membrane through which the N-terminal passenger domain is transported. Following transport, the passenger domain is generally cleaved by an outer membrane protease with the passenger domain either remaining in contact with the surface via a noncovalent interaction with the beta domain or cleaved to release a soluble protein. These proteins are highly diverse and perform a variety of functions that promote virulence, including catalyzing proteolysis, serving as an adhesin, mediating actin-promoted motility, or serving as a cytotoxin. Proteins in this family share similarity in the C-terminal region of the passenger domain as seen in the pertactin structure P.69, a Bordetella pertussis agglutinogen responsible for human pertussis. The P.69 protein consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is one of the largest beta-helix known to date.


Pssm-ID: 238156 [Multi-domain]  Cd Length: 186  Bit Score: 121.70  E-value: 1.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 361 SGAATHSGPTTLEAGTLTAGGADVfsavsahSVAANTTLDLNGFSQTLGSLDNR-GRVAFGS--NPGTVLTVSGNLTGHD 437
Cdd:cd00253    19 GGGALTLTGNSVWLGTLQAGGGTV-------SLNSNSLWTLTGDSTVNGNLTNSgGTVDFGSasGAFNTLTVNGNYLGGN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 438 GTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAGASNGKFTLVGdyslrgqpTIAAGAYG 517
Cdd:cd00253    92 GTFVLNTDLGGDNSPTDKLVVTGNASGTTNVAVVNAGGEGASTGDGIELVEVNGGSDAAFSLAG--------RVDAGAYE 163

                         170
                  ....*....|....*....
gi 2034439061 518 YQLHKGNATNAGDWYLRSQ 536
Cdd:cd00253   164 YTLYKGGVGNNGNWYLRST 182
PRK14849 PRK14849
autotransporter barrel domain-containing lipoprotein;
409-804 2.65e-31

autotransporter barrel domain-containing lipoprotein;


Pssm-ID: 184851 [Multi-domain]  Cd Length: 1806  Bit Score: 132.94  E-value: 2.65e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  409 GSLDNRGRVAF---GSNPGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIK 485
Cdd:PRK14849  1331 GNLENGGTVQMnseGGKPGNVLTVNGNYTGNNGLMTFNATLGGDNSPTDKMNVKGDTQGNTRVRVDNIGGVGAQTVNGIE 1410

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  486 VIDVAGASNGKFTLVgdyslrgQPTIAAGAYGYQLHKGNATNAGDWYLRSQRLAELPvnDDMPEPGSDQDPVSNSNPAPA 565
Cdd:PRK14849  1411 LIEVGGNSAGNFALT-------TGTVEAGAYVYTLAKGKGNDEKNWYLTSKWDGVTP--PDTPDPINNPPVVDPEGPSVY 1481

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  566 KPlyQAGvplyeTYARTLLGMNGLPT--LQQRVGTRSWntgSDSAPPKGIWSRTNVSNTSFDQRTSVSGASYSLSTSNFQ 643
Cdd:PRK14849  1482 RP--EAG-----SYISNIAAANSLFShrLHDRLGEPQY---IDSLHSQGSASSMWMRHVGGHERSRAGDGQLNTQANRYV 1551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  644 AGLDGEMASNSAGS-------LVAGISVHYGRSSADIISIYGDGDINtdGYGFGSAVTWY----GENGLYVDGQAQATWF 712
Cdd:PRK14849  1552 LQLGGDLAQWSSNAqdrwhlgVMAGYANQHSNTQSNRVGYKSDGRIS--GYSAGLYATWYqndaNKTGAYVDSWALYNWF 1629

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  713 DSDLSSRTASRN-------MASNNRGFGYTLGLETGARmDIAPAWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLT 785
Cdd:PRK14849  1630 DNSVSSDNRSADdydsrgvTASVEGGYTFEAGTFSGSE-GTLNTWYVQPQAQITWMGVKDSDHTRKDGTRIETEGDGNVQ 1708

                          410
                   ....*....|....*....
gi 2034439061  786 GRLGISLDYRSSWSDDSGR 804
Cdd:PRK14849  1709 TRLGVKTYLNSHHQRDDGK 1727
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 613-864 6.71e-30

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 119.41  E-value: 6.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 613 IWSRTNVSNTSFDQRTSVSGasYSLSTSNFQAGLDGEMASNsagsLVAGISVHYGRSSADIISiyGDGDINTDGYGFGSA 692
Cdd:pfam03797   1 VWARGFGGRGKQDGDGGAAG--YDADTGGLQVGADYRLGDN----LRLGVAFGYSRSDADVDG--RGGSGDSDSYSLGLY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 693 VTWYGENGLYVDGQAQATWFDSDLSSRTA----SRNMASNNRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSF 768
Cdd:pfam03797  73 GTYYGDGGWYLDGGLGYGWHDNDTRRSVDlggfSETAKGDYDGNGFGASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 769 TD---PFGARVSLDDGDSLTGRLGISLDYRSSWSDdsgriSSTRIYGITNLFYEFLDGTQTTVSGTPFASVH-------- 837
Cdd:pfam03797 153 TEsggAAALSVDSQSYDSLTGRLGLRLSYTFDLGG-----GTLTPYARLGWRHEFGDDDPVTTAAFAGLSGAgsftvaga 227

                         250       260
                  ....*....|....*....|....*....
gi 2034439061 838 --DRLWADVGFGGSFDWDDGkYSLYGEAS 864
Cdd:pfam03797 228 dlARDSLELGAGLSAQLSDN-LSLYANYD 255
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
261-797 8.34e-28

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 121.32  E-value: 8.34e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  261 KTGSSTWSLTESTRSYTPWRILEGTLRISSNEALGFENgSLTLANGATLETAASMrmDREVFLEAGGGTFQVASSTTLEL 340
Cdd:PRK09752   665 KTGAGTLELTASGTTQSAVRVEEGTLKGDVADIIPYAS-SLWVGDGATFVTGADQ--DIQSIDATSSGTIDISDGTVLRL 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  341 AGAVGGVGGLvkagegALLLSGAATHSGPTTleaGTLTAGGADVFSAVSAHSVAANTTLDLNgFSQTLGSLDNRGRVAfg 420
Cdd:PRK09752   742 TGQDTSVALN------ASLFNGDGTLVNATD---GVTLTGELNTNLETDSLTYLSDVTVNGN-LTNTSGAVSLQNGVA-- 809

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  421 snpGTVLTVSGNLTGhDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAgASNGKFTLV 500
Cdd:PRK09752   810 ---GDTLTVNGDYTG-GGTLLLDSELNGDDSVSDQLVLNGNTAGNTTVVVNSITGIGEPTSTGIKVVDFA-ADPTQFQNN 884

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  501 GDYSLRGQPTIAAGAYGYQLHKGNatnaGDWYLRSQRLAelPVNDDMPEPGSDQDPVSNSNPAPAKPlyqaGVPLYETYA 580
Cdd:PRK09752   885 AQFSLAGSGYVNMGAYDYTLVEDN----NDWYLRSQEVT--PPSPPDPDPTPDPDPTPDPDPTPDPE----PTPAYQPVL 954

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  581 RTLLG--MNGLPTLQQR-VGTRSWNTGSDSAPPK-----GIWSRTNVSNTSFDQRTSVSGASYSLSTSNFqaGLDGEMAS 652
Cdd:PRK09752   955 NAKVGgyLNNLRAANQAfMMERRDHAGGDGQTLNlrvigGDYHYTAAGQLAQHEDTSTVQLSGDLFSGRW--GDDGEWML 1032

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  653 NSAGslvaGISVHYGRSSADIISIYGDGdiNTDGYGFGSAVTWYG----ENGLYVDGQAQATWFDSDLSSRtasRNMASN 728
Cdd:PRK09752  1033 GIVG----GYSDNQGDSRSNMTGTRADN--QNHGYAVGLTSSWFQhgnqKQGAWLDSWLQYAWFNNDVSEQ---EDGTDH 1103

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2034439061  729 NRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLTGRLGISLDYRSS 797
Cdd:PRK09752  1104 YHSSGIIASLEAGYQWLPGRGVVIEPQAQVIYQGVQQDDFTAANHARVSQSQGDDIQTRLGLHSEWRTA 1172
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 620-864 1.34e-26

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 109.97  E-value: 1.34e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  620 SNTSFDQRTSVSGASYSLSTSNFQAGLDGEMASNsaGSLVAGISVHYGRSSADIISIYGDGDINTDGYGFGSAVTWYGEN 699
Cdd:smart00869   6 GFLRQDSSGSGGSAGFDYDSYGLQLGADYRLSDN--GNLSLGFAAGYGNSKVDFSGNKGSGKGDVDSYGLGLYAGYSLGN 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  700 GLYVDGQAQATWFDSDLSSRTA---SRNMASNNRGFGYTLGLETGARMDIAPAWSLTPQAQLAYSRASFDSFT----DPF 772
Cdd:smart00869  84 GLYLDAQLGYGRSDNDTKRKVTlggAGRAKGSYDGTGYGASLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTesggGAF 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  773 GARVSLDDGDSLTGRLGISLDYRSSWSDDsgriSSTRIYGITNLFYEFLDGTQTTV--------SGTPFASVHDRLWADV 844
Cdd:smart00869 164 GLSVDSQSLDSLSLPLGLRLEYRLALGDG----ATLTPYLRLAYVHDFYDDNPVVTasllgsgaSFTTSGTDLDRNAAEL 239

                          250       260
                   ....*....|....*....|
gi 2034439061  845 GFGGSFDWDDGkYSLYGEAS 864
Cdd:smart00869 240 GLGLSAKLSNG-LSLSLNYD 258
PRK15319 PRK15319
fibronectin-binding autotransporter adhesin ShdA;
311-793 7.77e-25

fibronectin-binding autotransporter adhesin ShdA;


Pssm-ID: 185219 [Multi-domain]  Cd Length: 2039  Bit Score: 112.10  E-value: 7.77e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  311 TAASMRMDREVFLEAGGGTFQVASSTTLELAGAVGGVGGLVKAGEGALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSA 390
Cdd:PRK15319  1421 TATSATPAHGTFTLGAGDSFEVTSVLGDKTGNGDWDGKSLTKLGAGKLTLSGANTYTGDTNVQEGTLWLSGDGSIGEMGS 1500

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  391 H---SVAANTTLDLNGFSQTLGSLDNRGRVAFG---------------------------SNPGTVLTVSGNLTGHDGTI 440
Cdd:PRK15319  1501 QqavNVASGATFGGSNGTTVNGKVTNEGTLVFGdseetgaiftlngdlinmgtmtsgsssSTPGNTLYVDGNYTGNGGSL 1580

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  441 LLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGlGDLTRDGIKVIDVAGASNGKftlvgDYSLRGQptIAAGAYGYQL 520
Cdd:PRK15319  1581 YLNTVLGDDDSATDKLVITGDASGTTDLYINGIGD-GAQTTNGIEVVDVGGVSTSD-----AFELKNE--VNAGLYTYRL 1652

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  521 HKGNATNagDWYL--RSQRLAELPVNDDMPEPGSDQ--------------------------DPVSNSNPAPAKPLYQAG 572
Cdd:PRK15319  1653 YWNESDN--DWYLasKAQSDDDDSGGDDTPSDGGDDggnvtppddggdggnvtppddggdggDVTPPDHGGDVAPQYRAD 1730

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  573 VPLY---ETYARTLlgmnGLPTLQQRVGTRSWNTGSDsappkgIWSRTNVSNTsfdQRTSVSG-ASYSLSTSNFQAGLDG 648
Cdd:PRK15319  1731 IGAYmgnQWMARNL----QMQTLYDREGSQYRNADGS------VWARFKAGKA---ESEAVSGnIDMDSNYSQFQLGGDI 1797

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  649 EMASNSAGSLVAGISVHYGRSSADIISIYG-DG-----DINTDGYGFGSAVTWYGE----NGLYVDGQAQATWFDSDLSS 718
Cdd:PRK15319  1798 LAWGNGQQSVTVGVMASYINADTDSTGNRGaDGsqftsSGNVDGYNLGVYATWFADaqthSGAYVDSWYQYGFYNNSVES 1877

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2034439061  719 RTASRNMASNNRGfgyTLGLETGARMDIAPA----WSLTPQAQLAYSRASFDSFTDPFGARVSLDDGDSLTGRLGISLD 793
Cdd:PRK15319  1878 GDAGSESYDSTAN---AVSLETGYRYDIALSngntVSLTPQAQVVWQNYSADSVKDNYGTRIDGQDGDSWTTRLGLRVD 1953
AC_1 pfam18883
Autochaperone Domain Type 1; This entry represents the autochaperone domain of type 1 (AC-1) ...
 407-520 3.66e-20

Autochaperone Domain Type 1; This entry represents the autochaperone domain of type 1 (AC-1) in the Type Va Secretion System (T5aSS). Autotransporters (ATs) belong to a family of modular proteins secreted by the Type V, subtype a, secretion system (T5aSS) and considered as an important source of virulence factors in lipopolysaccharidic diderm bacteria (archetypical Gram-negative bacteria). The AC of type 1 with beta-fold appears as a prevalent and conserved structural element exclusively associated to beta-helical AT passenger.


Pssm-ID: 465898 [Multi-domain]  Cd Length: 114  Bit Score: 86.51  E-value: 3.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 407 TLGSLDN-RGRVAF---GSNPGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTA-GSSILKVTNVGGLGDLTR 481
Cdd:pfam18883   2 NVTNLTNdNSTINFtapSGASYKTLTVDGDYTGNDGTLALNTYLGGDGSPSDKLVIDGGTAsGTTNLRINNTGGPGALTT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2034439061 482 -DGIKVIDVAGA-SNGKFTLVGdyslrgqpTIAAGAYGYQL 520
Cdd:pfam18883  82 nDGILVVDVGGTtSDGAFRLAG--------RAVAGPYEYLL 114
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
423-790 3.78e-16

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 83.31  E-value: 3.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 423 PGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAGASNGKFtlvgd 502
Cdd:PRK15313  456 PWQTLTINEDYVGNGGKLVFNTVLNDDDSETDRLQVLGNTSGNTFVAVNNIGGAGAQTIEGIEIVNVAGNSNGTF----- 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 503 yslRGQPTIAAGAYGYQLhkgnATNAGDWYLRS-----QRLAELPVNDDMPEP----GSDQDPVSNSNPAPAKP------ 567
Cdd:PRK15313  531 ---EKASRIVAGAYDYNV----VQKGKNWYLTSyiepdEPIIPDPVDPVIPDPvipdPVDPDPVDPVIPDPVIPdpvdpd 603

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 568 ------------------LYQAGVP--------------LYETYARTLLGMNglpTLQQRVG-TRSWNTGSDSAPPKGIW 614
Cdd:PRK15313  604 pvdpepvdpvipdptipdIGQSDTPpitehqfrpevgsyLANNYAANTLFMT---RLHDRLGeTQYTDMLTGEKKVTSLW 680

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 615 SRTNVSNTSFDQrtsvSGASYSLSTSNFQAGLDGEMASNSAGSL-------VAGISVHYGRSSADIISIYGDGDINtdGY 687
Cdd:PRK15313  681 MRNVGAHTRFND----GSGQLKTRINSYVLQLGGDLAQWSTDGLdrwhigaMAGYANSQNRTLSSVSDYHSRGQVT--GY 754

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 688 GFGSAVTWYGEN----GLYVDGQAQATWFDSDLSSRTASrnmASNNRGFGYTLGLETGARMDIAP----AWSLTPQAQLA 759
Cdd:PRK15313  755 SVGLYGTWYANNidrsGAYVDTWMLYNWFDNKVMGQDQA---AEKYKSKGITASVEAGYSFRLGEsahqSYWLQPKAQVV 831

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2034439061 760 YSRASFDSFTDPFGARVSLDDGDSLTGRLGI 790
Cdd:PRK15313  832 WMGVQADDNREANGTLVKDDTAGNLLTRMGV 862
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
409-804 5.61e-09

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 60.06  E-value: 5.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  409 GSLDNRGRVAFGSNPGTVLTVSGNL------------------------TGHDGTIL-LNASLGGDDSPADMVNVGGDTA 463
Cdd:NF033176   809 GNITNDADLSFGTAKLLSATVNGSLvnnkniilnptkesagntltvsnyTGTPGSVIsLGGVLEGDNSLTDRLVVKGNTS 888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  464 GSSILKVTNVGGLGDLTRDGIKVIDVAGASNGKFTLvgdyslrgQPTIAAGAYGYQLHKGN--ATNAGDWYLRSQrlaeL 541
Cdd:NF033176   889 GQSDIVYVNEGGSGGQTIEGINIISVEGNSDAEFSL--------KNRVVAGAYDYTLQKGNvsGTDKKGWYLTSH----L 956

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  542 PVNDD---MPEPGSdqdpvSNSNPAPAKPLYqagvplyetyartLLGMNGlptlQQRVGTRSWNTGSDSAppkGIWSRTN 618
Cdd:NF033176   957 PTSDTrqyRPENGS-----YATNMALANSLF-------------LMDLNE----RKQFSAVNDNTQPESA---SVWMKIT 1011

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  619 VSNTSfdqrTSVSGASYSLSTSNFQAGLDGEMASNSA---GSLVAGISVHYGRSSADIISIYGD-GDINT-DGYGFGSAV 693
Cdd:NF033176  1012 GGRTS----GKLSDGQNKTTTNQFINQLGGDIYKYHAeklGDFTLGIMGGYANAKGKTINHTSKkGARNTlDGYSAGLYG 1087

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  694 TWY----GENGLYVDGQAQATWFDS-----DLSSRTASRNMASNNRGFGYTLGLET-GARMDIAPAWSLTPQAQLAYSRA 763
Cdd:NF033176  1088 TWYqngaNATGLFAETWMQYNWFNAsvkgdGLEEEKYNLNGLTASVGGGYNLNVHTwTSPEGIKGEFWLQPHLQAVWMGV 1167

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2034439061  764 SFDSFTDPFGARVSLDDGDSLTGRLGI--SLDYRSSWSDDSGR 804
Cdd:NF033176  1168 TPDTHQEDNGTVVQGTGKNNLQTKAGIraSWKVKSSLDKDTGR 1210
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 3-802 2.41e-08

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 57.87  E-value: 2.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061   3 NSGTISGGRGGTTSPASEGLATGNGGAGGHGINGSDVTILNSGTVAGAQGGLGGILNWNIAGQGGDGIHGDRLSVTNAGI 82
Cdd:COG4625    17 TGGGGAGGGGGAGGGAGGGGAGGGGGGGGGGGGAGGGGGGGGTGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGTGGVGGG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  83 ISGGVGGDGSVYFSGSGPAGTGGAGIAGNDLMIVNTGMIAGGKTGAGEPGNYHIQGGPGIRGDRLTISNEAGGTISGGAG 162
Cdd:COG4625    97 GGGGGGGGGGGGGGGGGGGGGSAGGGGGGAGGAGGGGGGGAGGGGGGGGGGGAGGGGGGGAGGAGGGGGGGGGGGGGGGG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 163 KDIPDGWYPIGDGEGISGSDVTIFNAGGITGPKQAITFRGGTNRLELHSGWSILGTVEGYGESNTLALGGVANGT---FD 239
Cdd:COG4625   177 GGGGGGGGGGGGGGGGNGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGgggGG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 240 SSRLSGYNHPAGGFYAFGRFEKTGSSTWSLTESTRSYTPWRILEGTLRISSNEALGFENGSLTLANGATLETAASMRMDR 319
Cdd:COG4625   257 GNGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGG 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 320 EVFLEAGGGTFQVASSTTLELAGAVGGVGGLVKAGEGALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSAHSVAANTTL 399
Cdd:COG4625   337 GGGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGGGGGGSGGGGAGGGGGSGGGGGGGAGGGGGGGGAGGTGGGGAGGG 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 400 DLNGFSQTLGSLDNRGRVAFGSNPGTVLTVSGNLTGHDGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDL 479
Cdd:COG4625   417 GGAAGGGGGGTGAGGGGGGGGTGAGGGGATGGGGGGGGGAGGSGGGAGAGGGSGSGAGTLTLTGNNTYTGTTTVNGGGNY 496

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 480 TRD--GIKVIDVAGASNGKFTLVGDYSLRG---QPTIAAGAYGYQLHKGNATNAGDWYLRSQRLAELPVNDDMPEPGSDQ 554
Cdd:COG4625   497 TQSagSTLAVEVDAANSDRLVVTGTATLNGgtvVVLAGGYAPGTTYTILAVAAALDALAGNGDLSALYNALAALDAAAAR 576

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 555 DPVSNSNPAPAKPLYQAGVPLYETYARTLLGmnglptlQQRVGTRSWNTGSDSAPPKGIWSRTNVSNTSFDQRTSVSGas 634
Cdd:COG4625   577 AALDQLSGEIHASAAAALLQASRALRDALSN-------RLRALRGAGAAGDAAAEGWGVWAQGFGSWGDQDGDGGAAG-- 647

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 635 YSLSTSNFQAGLDGEMASNsagsLVAGISVHYGRSSADIISIYGDGDINTDGYGFGSAVTWygeNGLYVDGQAQATWFDS 714
Cdd:COG4625   648 YDSSTGGLLVGADYRLGDN----WRLGVALGYSRSDVDVDDRGSSGDSDSYHLGLYGGYQF---GALYLDGGLGYGWNDY 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061 715 DLSSRTA----SRNMASNNRGFGYTLGLETGARMDIaPAWSLTPQAQLAYSRASFDSFT---DPFGARVSLDDGDSLTGR 787
Cdd:COG4625   721 DTDRTIAfgglSRTATADYDGDTASAFLEAGYRFDL-GGLTLTPFAGLAYVRLRTDGFTetgGAAALSVDSQSTDSLRST 799

                         810
                  ....*....|....*
gi 2034439061 788 LGISLDYRSSWSDDS 802
Cdd:COG4625   800 LGLRASRTFSLGGGV 814
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 37-742 4.58e-03

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 40.91  E-value: 4.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061   37 SDVTILNSGTVAGAQGGLGGILNWNIAGQGGDGIHGDRLSVTNAGIISGGVGGDGSVYFSGSGPAGTGGAGIAGNDLMIV 116
Cdd:COG3210    800 ADGTITAAGTTAINVTGSGGTITINTATTGLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAATAASITV 879

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  117 NTGMIAGGKTGAGEPGNYHIQGGPGIRGDRLTISNEAGGTISGGAGKDIPDGWYPIGDGEGISGSDVTIFNAGGITGPKQ 196
Cdd:COG3210    880 GSGGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAASA 959

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  197 AITFRGGTNRLElhSGWSILGTVEGYGESNTLALGGVANGTFDSSRLSGYNHPAGGFYAFGRFEKTGSSTWSLTESTRSY 276
Cdd:COG3210    960 SDGAGDTGASSA--AGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTA 1037

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  277 TPWRILEGTLRISSNEALGFENGSLTLANGATLETAASMRMDREVFLEAGGGTFQVASSTTLELAGAVGGVGGLVKAGEG 356
Cdd:COG3210   1038 ATAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGGGGTAQASGAGTTHTLGGITNGGATGTSGGTTTSTGGVT 1117

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  357 ALLLSGAATHSGPTTLEAGTLTAGGADVFSAVSAHSVAANTTLDLNGFSQTLGSLDNRGRVAFGSNPGTVLTVSGNLTGH 436
Cdd:COG3210   1118 ASKVGGTTTVGATGTSTASTEAAGAGTLTGLVAVSAVAGGASSASAGDTTAVAAATTTTTGSAINGGADSAATEGTAGTD 1197

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  437 DGTILLNASLGGDDSPADMVNVGGDTAGSSILKVTNVGGLGDLTRDGIKVIDVAGASNGKFTLVGDYSLRGQPTIAAGAY 516
Cdd:COG3210   1198 LKGGDSTGGSTTTIGTTNVTTTTTLTASDTGNTTATGGSSAGQTGSFVAAGSASGTGDATTGATAGAVSNGATSTVAGNA 1277

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  517 GYQLHKGNATNAGDWYLRSQRLAELPVNDDMPEPGSDQDPVSNSNPAPAKPLYQAGVPLYETYARTLLGMNGLPTLQQRV 596
Cdd:COG3210   1278 GATATGSTVDIGSTSATSAGGSLDTTGNTAGANGATVGTGIGGTTATGTAVAAVNSGGVNAGGGTINTTAANTGLNGGNG 1357

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034439061  597 GTRSWNTGSDSAPPKGIWSRTNVSNTSFDQRTSVSGASYSLSTSNFQAGLDGEMASNSAGSLVAGISVHYGRSSADIISI 676
Cdd:COG3210   1358 ATDSAAGAGSGGAAGSLAATAGAGTVLTGAGNNTGAEGTNAGRDGGVTTSGTGVGNNGGVSGTTVAGTTGSSATTGTGGT 1437

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2034439061  677 YGDGDINTDGYGFGSAVTWYGENGLYVDGQAQATWFDSDLSSRTASRNMASNNRGFGYTLGLETGA 742
Cdd:COG3210   1438 GNTTGTSVAGAGGGNADASAINTGNASSLGAGGSTAGNAVGGAVIGGTTTGGNGAGVAGATASNGG 1503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH