|
Name |
Accession |
Description |
Interval |
E-value |
| mtnA |
PRK05720 |
methylthioribose-1-phosphate isomerase; Reviewed |
5-363 |
0e+00 |
|
methylthioribose-1-phosphate isomerase; Reviewed
Pssm-ID: 235578 Cd Length: 344 Bit Score: 518.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 5 GTPYRSVWRPlddrKSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQNDASDA------ 78
Cdd:PRK05720 1 LQPRPVAWKD----GAVRILDQRKLPHEVEYVELTTAEEVADAIRDMVVRGAPAIGIAAAYGMALAAREDASDDgeeflk 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 79 SLEKSAAALVETRPTAINLRWAIERMVNHLRPLPASQRVEAGYLEADAICDEDVQVNEAIGRHGLELIREiwerkgrqgT 158
Cdd:PRK05720 77 KLEEAAAYLAASRPTAVNLFWALDRMREVLAPLPGAERKAALEEEAIEIHEEDVEINRAIGEHGLTLIRK---------G 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 159 VNLLTHCNAGWIATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVD 238
Cdd:PRK05720 148 QGILTHCNAGWLATAGYGTALAPIYAAKEKGIDIHVYADETRPRLQGARLTAWELYQAGIDVTVITDNMAAHLMQTGKID 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 239 MVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrV 318
Cdd:PRK05720 228 AVIVGADRIAANGDVANKIGTYQLAIAAKYHGVPFYVAAPSSTIDLTLADG-KEIPIEERDPEEVTEVGG---------V 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2035452906 319 RVAPERSPAANPAFDVTPARLVTGLITERGRCDAS-AAGLNRLFPG 363
Cdd:PRK05720 298 RIAPEGVKVYNPAFDVTPAELITGIITEKGIVAPPdTANLAALFPE 343
|
|
| MtnA |
COG0182 |
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ... |
6-362 |
0e+00 |
|
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];
Pssm-ID: 439952 Cd Length: 343 Bit Score: 514.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 6 TPYRSVWRpldDRKSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQNDASD------AS 79
Cdd:COG0182 1 DKVRTIWW---DGGALVLLDQTLLPHEEEYVELTTVEDVAEAIRDMVVRGAPAIGVAAAYGVALAAREAAADdreeflAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 80 LEKSAAALVETRPTAINLRWAIERMVNHLRPLP-ASQRVEAGYLEADAICDEDVQVNEAIGRHGLELIREiwerkgrqgT 158
Cdd:COG0182 78 LEEAAEYLAATRPTAVNLFWALDRMLAALEELPsVEEIREALLAEALAIADEDVAANRAIGEHGAELIPD---------G 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 159 VNLLTHCNAGWIATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVD 238
Cdd:COG0182 149 DTILTHCNAGALATVGYGTALGVIRAAHEAGKLIHVYADETRPLLQGARLTAWELMQDGIPVTLITDNAAGHLMQRGKVD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 239 MVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrV 318
Cdd:COG0182 229 AVIVGADRIAANGDVANKIGTYGLAVLAKHHGIPFYVAAPTSTIDLSLPDG-EDIPIEERDPDEVTHVGG---------R 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2035452906 319 RVAPERSPAANPAFDVTPARLVTGLITERGRCDAS-AAGLNRLFP 362
Cdd:COG0182 299 RIAPEGVPVYNPAFDVTPAELITAIITEKGVIRPPyEENLAKLFP 343
|
|
| salvage_mtnA |
TIGR00512 |
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ... |
18-352 |
4.03e-151 |
|
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 273112 [Multi-domain] Cd Length: 335 Bit Score: 429.36 E-value: 4.03e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 18 RKSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQND------ASDASLEKSAAALVETR 91
Cdd:TIGR00512 7 RGSLEILDQRLLPHESEYIEVTTVEDVADAIRDMRVRGAPAIGIVAAYGLALAAREGetdegeEFKAFLEEKLQYLVSSR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 92 PTAINLRWAIERMVNHLRPLPASQRVEAGYL-EADAICDEDVQVNEAIGRHGLELIREIwerKGRQGTVNLLTHCNAGWI 170
Cdd:TIGR00512 87 PTAVNLSWALDRMRAALREAKTVADIKEALLaEAERILEEDLEDNRAIGENGAALIKKG---VAAKEPVRVLTHCNTGSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 171 ATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVDMVIVGTDRVTAQ 250
Cdd:TIGR00512 164 ATAGYGTALGVIRSAHEKGRLEHVYADETRPYNQGARLTAWELVQEGIPATLITDSMAAHLMKHGEVDAVIVGADRIAAN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 251 GDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrVRVAPERSPAANP 330
Cdd:TIGR00512 244 GDTANKIGTYQLAILAKHHGVPFYVAAPTSTIDLELADG-AEIPIEERPPEEVTHVGG---------VRIAPPGIGVWNP 313
|
330 340
....*....|....*....|..
gi 2035452906 331 AFDVTPARLVTGLITERGRCDA 352
Cdd:TIGR00512 314 AFDVTPAELITGIITEKGVITP 335
|
|
| IF-2B |
pfam01008 |
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ... |
52-348 |
7.58e-80 |
|
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.
Pssm-ID: 395798 [Multi-domain] Cd Length: 281 Bit Score: 246.05 E-value: 7.58e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 52 QVRGAPLIGAVAAYGLVFALQN-DASDA-----SLEKSAAALVETRPTAINLRWAIERMVNHLRPLPASQRVEAG----Y 121
Cdd:pfam01008 1 KVRGSPAIAIAALEGLLLVIQDaRTPTVaelkeQLRSAIEFLISARPTAVSLGNAIDRLLRIVLALHSSSDVEEAkeslI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 122 LEADAICDEDVQVNEAIGRHGLELIREiwerkgrqGTVnLLTHCNAGwiatvdwgTALAPIYMAHDEGIPVHVWVDETRP 201
Cdd:pfam01008 81 EAADEFIDEIEEARRKIGAIAAELIKD--------GDT-ILTHCNSG--------TVLGVLRAAHKEGKRFRVIVTESRP 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 202 RNQGSLlTAWELGSHGVAHTVIADNAGGHYMQagRVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSST 281
Cdd:pfam01008 144 RLQGRL-TAKELVQAGIPVTLITDSAVGYVMQ--EVDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYK 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2035452906 282 IDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrVRVAPERSPAANPAFDVTPARLVTGLITERG 348
Cdd:pfam01008 221 FDPRFPLD-EDIFIEERDPEEVLYRTG---------VRIAPPNLKVRNPAFDYTPPELITLIITEVG 277
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| mtnA |
PRK05720 |
methylthioribose-1-phosphate isomerase; Reviewed |
5-363 |
0e+00 |
|
methylthioribose-1-phosphate isomerase; Reviewed
Pssm-ID: 235578 Cd Length: 344 Bit Score: 518.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 5 GTPYRSVWRPlddrKSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQNDASDA------ 78
Cdd:PRK05720 1 LQPRPVAWKD----GAVRILDQRKLPHEVEYVELTTAEEVADAIRDMVVRGAPAIGIAAAYGMALAAREDASDDgeeflk 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 79 SLEKSAAALVETRPTAINLRWAIERMVNHLRPLPASQRVEAGYLEADAICDEDVQVNEAIGRHGLELIREiwerkgrqgT 158
Cdd:PRK05720 77 KLEEAAAYLAASRPTAVNLFWALDRMREVLAPLPGAERKAALEEEAIEIHEEDVEINRAIGEHGLTLIRK---------G 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 159 VNLLTHCNAGWIATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVD 238
Cdd:PRK05720 148 QGILTHCNAGWLATAGYGTALAPIYAAKEKGIDIHVYADETRPRLQGARLTAWELYQAGIDVTVITDNMAAHLMQTGKID 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 239 MVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrV 318
Cdd:PRK05720 228 AVIVGADRIAANGDVANKIGTYQLAIAAKYHGVPFYVAAPSSTIDLTLADG-KEIPIEERDPEEVTEVGG---------V 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2035452906 319 RVAPERSPAANPAFDVTPARLVTGLITERGRCDAS-AAGLNRLFPG 363
Cdd:PRK05720 298 RIAPEGVKVYNPAFDVTPAELITGIITEKGIVAPPdTANLAALFPE 343
|
|
| MtnA |
COG0182 |
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ... |
6-362 |
0e+00 |
|
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];
Pssm-ID: 439952 Cd Length: 343 Bit Score: 514.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 6 TPYRSVWRpldDRKSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQNDASD------AS 79
Cdd:COG0182 1 DKVRTIWW---DGGALVLLDQTLLPHEEEYVELTTVEDVAEAIRDMVVRGAPAIGVAAAYGVALAAREAAADdreeflAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 80 LEKSAAALVETRPTAINLRWAIERMVNHLRPLP-ASQRVEAGYLEADAICDEDVQVNEAIGRHGLELIREiwerkgrqgT 158
Cdd:COG0182 78 LEEAAEYLAATRPTAVNLFWALDRMLAALEELPsVEEIREALLAEALAIADEDVAANRAIGEHGAELIPD---------G 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 159 VNLLTHCNAGWIATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVD 238
Cdd:COG0182 149 DTILTHCNAGALATVGYGTALGVIRAAHEAGKLIHVYADETRPLLQGARLTAWELMQDGIPVTLITDNAAGHLMQRGKVD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 239 MVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrV 318
Cdd:COG0182 229 AVIVGADRIAANGDVANKIGTYGLAVLAKHHGIPFYVAAPTSTIDLSLPDG-EDIPIEERDPDEVTHVGG---------R 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2035452906 319 RVAPERSPAANPAFDVTPARLVTGLITERGRCDAS-AAGLNRLFP 362
Cdd:COG0182 299 RIAPEGVPVYNPAFDVTPAELITAIITEKGVIRPPyEENLAKLFP 343
|
|
| salvage_mtnA |
TIGR00512 |
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ... |
18-352 |
4.03e-151 |
|
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 273112 [Multi-domain] Cd Length: 335 Bit Score: 429.36 E-value: 4.03e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 18 RKSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQND------ASDASLEKSAAALVETR 91
Cdd:TIGR00512 7 RGSLEILDQRLLPHESEYIEVTTVEDVADAIRDMRVRGAPAIGIVAAYGLALAAREGetdegeEFKAFLEEKLQYLVSSR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 92 PTAINLRWAIERMVNHLRPLPASQRVEAGYL-EADAICDEDVQVNEAIGRHGLELIREIwerKGRQGTVNLLTHCNAGWI 170
Cdd:TIGR00512 87 PTAVNLSWALDRMRAALREAKTVADIKEALLaEAERILEEDLEDNRAIGENGAALIKKG---VAAKEPVRVLTHCNTGSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 171 ATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVDMVIVGTDRVTAQ 250
Cdd:TIGR00512 164 ATAGYGTALGVIRSAHEKGRLEHVYADETRPYNQGARLTAWELVQEGIPATLITDSMAAHLMKHGEVDAVIVGADRIAAN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 251 GDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrVRVAPERSPAANP 330
Cdd:TIGR00512 244 GDTANKIGTYQLAILAKHHGVPFYVAAPTSTIDLELADG-AEIPIEERPPEEVTHVGG---------VRIAPPGIGVWNP 313
|
330 340
....*....|....*....|..
gi 2035452906 331 AFDVTPARLVTGLITERGRCDA 352
Cdd:TIGR00512 314 AFDVTPAELITGIITEKGVITP 335
|
|
| eIF-2B_rel |
TIGR00524 |
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes ... |
43-348 |
5.80e-109 |
|
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF-2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF-2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF-2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins. [Unknown function, General]
Pssm-ID: 273119 [Multi-domain] Cd Length: 303 Bit Score: 321.31 E-value: 5.80e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 43 AVAHAICTMQVRGAPLIGAVAAYGLVFALQN------DASDASLEKSAAALVETRPTAINLRWAIERMvnhLRPLPASQR 116
Cdd:TIGR00524 6 DVAEAIKSMVVRGAPAIGVAAAYGLALAALKishvnvEEFKEDLEKAADFLLSTRPTAVNLFWALDRV---LNSLKSGES 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 117 VEAG----YLEADAICDEDVQVNEAIGRHGLELIREiwerkgrQGTVnlLTHCNAGWIATVDWGTALAPIYMAHDEGIPV 192
Cdd:TIGR00524 83 VEEFkeslLREAIEIINEDLETNRKIGENGAKLIKD-------GDTV--LTHCNAGALATSGYGTALGVIRSAWEDGKRI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 193 HVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVP 272
Cdd:TIGR00524 154 RVIADETRPRNQGSRLTAWELVQDGIPVTLITDSAAAYFMQTGEIDAVIVGADRIARNGDVANKIGTYQLAVLAKEFRIP 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2035452906 273 FWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrVRVAPERSPAANPAFDVTPARLVTGLITERG 348
Cdd:TIGR00524 234 FFVAAPLSTFDPKTSTG-EDIIIEERDPEEVAQVGG---------VRIAPLGVKVYNPAFDITPHDLIDAIITEKG 299
|
|
| PRK06371 |
PRK06371 |
S-methyl-5-thioribose-1-phosphate isomerase; |
9-348 |
3.39e-101 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 180547 Cd Length: 329 Bit Score: 302.20 E-value: 3.39e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 9 RSVWrpLDDRKsIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFA-LQNDASDASLEKsaaaL 87
Cdd:PRK06371 13 KAVW--YEDGE-VKLIDQRKLPDKIEIFEAKNSDDVAYAIKNMVVRGAPAIGVTAAYGLAMAsKNGENMDEAVEK----I 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 88 VETRPTAINLRWAIERMVNHLRPLPASQRVeagyleadaiCDEDVQVNEAIGRHGLELIREiwerkgrqgTVNLLTHCNA 167
Cdd:PRK06371 86 RSTRPTAYDLFKAIRYMNSNEFDMNAARRY----------AMEIIGRSKKIGEYGNELIKN---------GARILTHCNA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 168 GWIATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVDMVIVGTDRV 247
Cdd:PRK06371 147 GALAVVDWGTALAPIRIAHRNGKNIFVFVDETRPRLQGARLTAWELAQEGIDHAIIADNAAGYFMRKKEIDLVIVGADRI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 248 TAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrVRVAPERSPA 327
Cdd:PRK06371 227 ASNGDFANKIGTYEKAVLAKVNGIPFYVAAPGSTFDFSIKSG-DEIPIEERDENEVLEING---------CRIGPQESHA 296
|
330 340
....*....|....*....|.
gi 2035452906 328 ANPAFDVTPARLVTGLITERG 348
Cdd:PRK06371 297 RNPAFDVTPNEYVTGFITEYG 317
|
|
| PRK06036 |
PRK06036 |
S-methyl-5-thioribose-1-phosphate isomerase; |
16-348 |
4.65e-92 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 180362 Cd Length: 339 Bit Score: 279.30 E-value: 4.65e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 16 DDRKSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQN-DASDAS-----LEKSAAALVE 89
Cdd:PRK06036 8 DESNSVKLIDQTLLPEEYKVIECKTLESLCEAIKSLRVRGAPALGAAGGYGIALAARLsKAKDVDellkdLKVAAETLKS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 90 TRPTAINLRWAIERMVNHLRPLPASQRVEAGYL-EADAICDEDVQVNEAIGRHGLELIREiwerkgrQGTVnlLTHCNAG 168
Cdd:PRK06036 88 TRPTAVNLSWGVDRVLKAALDAEDVEEIRDIALrEAERIAEEDVARNKLIGKHGAKLLED-------GDTV--LTHCNAG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 169 WIATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVDMVIVGTDRVT 248
Cdd:PRK06036 159 RLACVDWGTALGVIRSAVEQGKEIKVIACETRPLNQGSRLTTWELMQDNIPVTLITDSMAGIVMRQGMVDKVIVGADRIT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 249 aQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvkEIPIEERSQDEVLFVPGldahgnqsrVRVAPERSPAA 328
Cdd:PRK06036 239 -RDAVFNKIGTYTHSVLAKEHEIPFYVAAPLSTFDFEGWEG--SVKIEERDPDELRYCGK---------TQIAPKDVPVY 306
|
330 340
....*....|....*....|
gi 2035452906 329 NPAFDVTPARLVTGLITERG 348
Cdd:PRK06036 307 NPAFDATPMENVTAIITEKG 326
|
|
| PRK08334 |
PRK08334 |
S-methyl-5-thioribose-1-phosphate isomerase; |
19-348 |
3.75e-88 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 169386 Cd Length: 356 Bit Score: 269.91 E-value: 3.75e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 19 KSIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLvfALQNDASDAS--------LEKSAAALVET 90
Cdd:PRK08334 22 GKVYMIDQRLLPREFKVIELRTVEEVAEAIKTMTVRGAPAIGAAAAFGL--ALYAETSKAKtkdefmdgFYKAYETLKNT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 91 RPTAINLRWA---IERMVNHLRPLPASQRVEAGYLEADAICDEDVQVNEAIGRHGLELIREiwerkgrqgtVNLLTHCNA 167
Cdd:PRK08334 100 RPTAVNLFWAlnrIKKLVEEHLEDPLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPE----------GNVLTHCNA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 168 GWIATVDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRVDMVIVGTDRV 247
Cdd:PRK08334 170 GSLATVHLGTVGAVLRVMHKDGTLKLLWVDETRPVLQGARLSAWEYHYDGIPLKLISDNMAGFVMQQGKVDAIIVGADRI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 248 TAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrVRVAPErSPA 327
Cdd:PRK08334 250 VANGDFANKIGTYTLAVLAKEHGIPFFTVAPLSTIDMSLKSG-KEIPIEERSPEEVLTCGG---------CRIAPD-VDV 318
|
330 340
....*....|....*....|.
gi 2035452906 328 ANPAFDVTPARLVTGLITERG 348
Cdd:PRK08334 319 YNPAFDVTPHKYLTGIITDRG 339
|
|
| IF-2B |
pfam01008 |
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ... |
52-348 |
7.58e-80 |
|
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.
Pssm-ID: 395798 [Multi-domain] Cd Length: 281 Bit Score: 246.05 E-value: 7.58e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 52 QVRGAPLIGAVAAYGLVFALQN-DASDA-----SLEKSAAALVETRPTAINLRWAIERMVNHLRPLPASQRVEAG----Y 121
Cdd:pfam01008 1 KVRGSPAIAIAALEGLLLVIQDaRTPTVaelkeQLRSAIEFLISARPTAVSLGNAIDRLLRIVLALHSSSDVEEAkeslI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 122 LEADAICDEDVQVNEAIGRHGLELIREiwerkgrqGTVnLLTHCNAGwiatvdwgTALAPIYMAHDEGIPVHVWVDETRP 201
Cdd:pfam01008 81 EAADEFIDEIEEARRKIGAIAAELIKD--------GDT-ILTHCNSG--------TVLGVLRAAHKEGKRFRVIVTESRP 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 202 RNQGSLlTAWELGSHGVAHTVIADNAGGHYMQagRVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSST 281
Cdd:pfam01008 144 RLQGRL-TAKELVQAGIPVTLITDSAVGYVMQ--EVDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYK 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2035452906 282 IDWRVQDGvKEIPIEERSQDEVLFVPGldahgnqsrVRVAPERSPAANPAFDVTPARLVTGLITERG 348
Cdd:pfam01008 221 FDPRFPLD-EDIFIEERDPEEVLYRTG---------VRIAPPNLKVRNPAFDYTPPELITLIITEVG 277
|
|
| PRK05772 |
PRK05772 |
S-methyl-5-thioribose-1-phosphate isomerase; |
12-348 |
5.02e-79 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 168237 Cd Length: 363 Bit Score: 246.59 E-value: 5.02e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 12 WRplDDRksIRIFDQTRLPWNLEELELRDEEAVAHAICTMQVRGAPLIGAVAAYGLVFALQN------DASDASLEKSAA 85
Cdd:PRK05772 21 WK--DNT--LTLLDQSLLPFETVYVDLKTVEEVALAIRNMQVRGAPAIGITAGYGMVLALIEnnvktlDDAIRELTRAKT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 86 ALVETRPTAINLRWAIERMVNHLRPLPASQR-------VEAGYLEADAICDEDVQVNEAIGRHGLELIREiwerkgrQGT 158
Cdd:PRK05772 97 ILDSARPTAVNLVWATSRMLNKAKNTVESGNaksvnelIELLKVEAKKIFEEEYDAEIQMGLYGLEKLND-------GDT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 159 VnlLTHCNAGWIAT-VDWGTALAPIYMAHDEGIPVHVWVDETRPRNQGSLLTAWELGSHGVAHTVIADNAGGHYMQAGRV 237
Cdd:PRK05772 170 V--LTQCNAGGLATgTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTAVGLVMYKDMV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 238 DMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQdgVKEIPIEERSQDEVLFVPGldahgnqsr 317
Cdd:PRK05772 248 NNVMVGADRILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSTFDLKSD--VNDVKIEERDPNEVRTIRG--------- 316
|
330 340 350
....*....|....*....|....*....|.
gi 2035452906 318 VRVAPERSPAANPAFDVTPARLVTGLITERG 348
Cdd:PRK05772 317 VPITPEDVNVYNPVFDVTPPKYITGIITEKG 347
|
|
| GCD2 |
COG1184 |
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ... |
45-348 |
8.15e-55 |
|
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family is part of the Pathway/BioSystem: Translation factors
Pssm-ID: 440797 [Multi-domain] Cd Length: 304 Bit Score: 182.36 E-value: 8.15e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 45 AHAICTMQVRGAPLIGAVAAYGL------VFALQNDASDASLEKSAAALVETRPTAINLRWAIERMVNHLRPL----PAS 114
Cdd:COG1184 8 AEEIREMEIHGAARIARAAAEALrdlaerSRAADPEEFRRELEAAARALRRARPSAASLPNAVRRVLARVADGetveEAR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 115 QRVEAgylEADAICDEDVQVNEAIGRHGLELIREiwerkgrqGTVnLLTHCNAGwiatvdwgTALAPIYMAHDEGIPVHV 194
Cdd:COG1184 88 EAVLE---AADEFIERAEEAKERAAEIAAKRIRD--------GDT-ILTHSNSS--------TVLAAIEAAVPQGKDIRV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 195 WVDETRPRNQGsLLTAWELGSHGVAHTVIADNAGGHYMqaGRVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFW 274
Cdd:COG1184 148 YVTESRPRYQG-RITARELAEAGVPVTLIVDSAARHFL--KEVDRVVVGADTITADGAVVNKIGTSPLALAAREAGVPVT 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2035452906 275 VALPSSTIdwrVQDGVKEIPIEERSQDEVLfvpgldahgnqsrvRVAPERSPAANPAFDVTPARLVTGLITERG 348
Cdd:COG1184 225 VAAETYKF---SPETFELVEIEERDPSEVY--------------DEEPEGVTVRNPAFDVTPPDLIDAIITERG 281
|
|
| PRK08535 |
PRK08535 |
ribose 1,5-bisphosphate isomerase; |
45-348 |
2.06e-50 |
|
ribose 1,5-bisphosphate isomerase;
Pssm-ID: 236282 [Multi-domain] Cd Length: 310 Bit Score: 170.85 E-value: 2.06e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 45 AHAICTMQVRGAPLIGAVAAYGLV-FALQNDASD-----ASLEKSAAALVETRPTAINLRWAIeRMVNHLRplpASQRVE 118
Cdd:PRK08535 11 AEKIKTMEIRGAGRIARAAAEALKdQAEKSDAESpeefkAEMRAAANILISTRPTAVSLPNAV-RYVMRYY---SGETVE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 119 AgyLEADAICDEDVQVNEAigRHGLELIREIWERKGRQGTVnLLTHCNAGwiatvdwgTALAPIYMAHDEGIPVHVWVDE 198
Cdd:PRK08535 87 E--ARESVIERAEEFIESS--ENAVEKIGEIGAKRIRDGDV-IMTHCNSS--------AALSVIKTAHEQGKDIEVIATE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 199 TRPRNQGsLLTAWELGSHGVAHTVIADNAGGHYMQagRVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVA-- 276
Cdd:PRK08535 154 TRPRNQG-HITAKELAEYGIPVTLIVDSAVRYFMK--DVDKVVVGADAITANGAVINKIGTSQIALAAHEARVPFMVAae 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2035452906 277 ---LPSSTIdwrvqdgVKE-IPIEERSQDEVLFVPGLDAHGNqsrVRVaperspaANPAFDVTPARLVTGLITERG 348
Cdd:PRK08535 231 tykFSPKTL-------LGElVEIEERDPTEVLPEEILAKLPG---VKV-------RNPAFDVTPPEYIDAIITEIG 289
|
|
| ribulose_e2b2 |
TIGR00511 |
ribose-1,5-bisphosphate isomerase, e2b2 family; The delineation of this family was based ... |
45-348 |
2.04e-49 |
|
ribose-1,5-bisphosphate isomerase, e2b2 family; The delineation of this family was based originally, in part, on a discussion and neighbor-joining phylogenetic study by Kyrpides and Woese of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. Recently, Sato, et al. assigned the function ribulose-1,5 bisphosphate isomerase. [Energy metabolism, Other]
Pssm-ID: 188057 Cd Length: 301 Bit Score: 168.36 E-value: 2.04e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 45 AHAICTMQVRGAPLIGAVAAYGL-VFALQNDASD-----ASLEKSAAALVETRPTAINLRWAIERMVNHLRPLPASQRVE 118
Cdd:TIGR00511 6 AEKIRTMEIRGAGRIARAAAAALrEQAEKSDAASpeefrAEMRAAANILISTRPTAVSLPNALRYVLKYMSGADVETLRQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 119 AGYLEADAICDedvQVNEAIGRHGlelirEIWERKGRQGTVnLLTHCNAGwiatvdwgTALAPIYMAHDEGIPVHVWVDE 198
Cdd:TIGR00511 86 SVIERADEFIN---RSEKAQERIG-----EIGAKRIRDGDV-IMTHCNSE--------AALSVIKTAFEQGKDIEVIVTE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 199 TRPRNQGsLLTAWELGSHGVAHTVIADNAGGHYMQAgrVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVAlp 278
Cdd:TIGR00511 149 TRPRNQG-HITAKELRDYGIPVTLIVDSAARYYMKE--VDHVVVGADAITANGAVINKIGTSQLALAAREARVPFMVA-- 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2035452906 279 SSTIDWRVQDGVKE-IPIEERSQDEVLfvPGlDAHGNQSRVRVAperspaaNPAFDVTPARLVTGLITERG 348
Cdd:TIGR00511 224 AETYKFHPKTITGElVEIEERDPTEVL--DE-EDLKQLGNVKVR-------NPAFDVTPPEYVDAIITERG 284
|
|
| PRK08335 |
PRK08335 |
translation initiation factor IF-2B subunit alpha; Validated |
52-348 |
4.16e-17 |
|
translation initiation factor IF-2B subunit alpha; Validated
Pssm-ID: 169387 Cd Length: 275 Bit Score: 80.59 E-value: 4.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 52 QVRGAPLIGAVAAYGLVfALQNDASDASLEKsaaALVETRPTAINLRWAIERMVNHLRPLPASQRVEAGYLEADAICDED 131
Cdd:PRK08335 17 RIRGASWLAKKGAEAYL-LLAEELDGEELEN---ALKELREEIPEVNPTMASLYNLARFIPITNNPELVKSRAEEFLRLM 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 132 VQVNEAIGRHGLELIReiwerkgrQGTVnLLTHCNAGwiatvdwgTALAPIYMAHDEGIPVHVWVDETRPRNQGsLLTAW 211
Cdd:PRK08335 93 EEAKREIGNIGSELID--------DGDV-IITHSFSS--------AVLEILKTAKRKGKRFKVILTESAPDYEG-LALAN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 212 ELGSHGVAHTVIADNAGGHYmqAGRVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWVALPSSTIDWRVQDGvk 291
Cdd:PRK08335 155 ELEFLGIEFEVITDAQLGLF--AKEATLALVGADNVTRDGYVVNKAGTYLLALACHDNGVPFYVAAETFKFHPELKSE-- 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2035452906 292 EIPIEERsqdevlfvpglDAHGNQSRVRvaperspaaNPAFDVTPARLVTGLITERG 348
Cdd:PRK08335 231 EVELVER-----------PYARQGHRVR---------NVLFDVTPWKYVRGIITELG 267
|
|
| PRK06372 |
PRK06372 |
translation initiation factor IF-2B subunit delta; Provisional |
146-348 |
3.41e-08 |
|
translation initiation factor IF-2B subunit delta; Provisional
Pssm-ID: 235788 [Multi-domain] Cd Length: 253 Bit Score: 53.76 E-value: 3.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 146 IREIWERKGRQGTVNLLTHCNAGWIATVDWGTALAPiYMAHDEGIPvHVWVDETRPRNQGSLLtAWELGSHGVAHTVIAD 225
Cdd:PRK06372 66 LKLGIEKHEKMAIEHAKPLFNDSVIGTISSSQVLKA-FISSSEKIK-SVYILESRPMLEGIDM-AKLLVKSGIDVVLLTD 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035452906 226 naGGHYMQAGRVDMVIVGTDRVTAQGDVANKIGTYLKALAARDNNVPFWvalpSSTIDWRVQDGvkeipIEERSqdevlf 305
Cdd:PRK06372 143 --ASMCEAVLNVDAVIVGSDSVLYDGGLIHKNGTFPLALCARYLKKPFY----SLTISMKIERN-----FLYST------ 205
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2035452906 306 VPGLDAHGNQSrvrvAPERSPAANPAFDVTPARLVTGLITERG 348
Cdd:PRK06372 206 YPNFKNHPCSE----WNIDIPCINRYFDKTPPDLIDYYINENG 244
|
|
| |
