|
Name |
Accession |
Description |
Interval |
E-value |
| Peptidase_M30 |
pfam10460 |
Peptidase M30; This family contains the metallopeptidase hyicolysin. Hyicolysin has a zinc ion ... |
498-821 |
1.49e-40 |
|
Peptidase M30; This family contains the metallopeptidase hyicolysin. Hyicolysin has a zinc ion which is liganded by two histidine and one glutamate residue.
Pssm-ID: 431298 Cd Length: 369 Bit Score: 153.55 E-value: 1.49e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 498 FCSNGGAgtagFDALTDIMGDAYGTKSYSNTIGDTNGLLDInVVVPNVPSTTKWG--GYFWGGNNFLKTAfPSTKDSNEA 575
Cdd:pfam10460 47 FANSGGI----YDMLVNVGGPVWGPNSYGTMIPGTGQPIDI-VILNFDHNGQPFGtvGYFWSMNNFKKSA-GQAQNSNES 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 576 LVFFVNGQQVS----QALNYYKSTLMHEAVHMINFYQRAFVLDT--AHDTWLEETTAMMGEDILAKTIFGGsYNEMTQVR 649
Cdd:pfam10460 121 ISLYLDSETLYlggaSGMQSMLTTMAHEGTHMQNFYRRQVSMGAayAFDTWLEEMTAMMMEDFASHDIDPT-YNAIRDLR 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 650 IPQYLRTGGG---VSYVNWTNL--SSDSYAFGGAFGAFINRKYGLSMFKKIVTDCNDGktvngvkvtSYACMDTLIKGV- 723
Cdd:pfam10460 200 FPDYYRYGGGsynCNLTTWTPFgaSCESYSVSGSLGGFLNRQLGLAFYKDLLTRATTG---------SKTVLDQAIRAAq 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 724 GGVGMGDELAKFGISLWGNTPASALPSGLGFPQRTvDGVF--DAIDVATVVKSL--KITAKSPATMVPTSHYFAQETIAA 799
Cdd:pfam10460 271 PGWTFEQALRNFKATTTALLPAASAPAGFGFPGRT-DGVFtlPQIDPSLPAYAAlrKLPASAPATLQAYGTYPVVRSDVS 349
|
330 340
....*....|....*....|..
gi 2037276277 800 GAtnYSKSgVIVPAGATLHIMV 821
Cdd:pfam10460 350 GT--YSET-VRVPAGATLSVVV 368
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
35-301 |
2.20e-18 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 90.91 E-value: 2.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 35 APLPTVSVSISTSglpVMYTGRSVSLSATGTSSANlALTYSWDFGDSTAAGTG--VTSAHTFAKAGTYTVKVTATDTngt 112
Cdd:TIGR00864 1085 AILPRVAIGTEDG---LLLAGKPADFEAHPLPSPG-GIHYEWDFGDGSALLQGrqPAAAHTFAKRGPFHVCLEVNNT--- 1157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 113 kasASGTVTIVDAVLTAPTITPSVASSIA---GNAVTFTGASSdpSGGKLTYSWDFGDGSKDTGT--TVSHSFATAGTYA 187
Cdd:TIGR00864 1158 ---ISGAAACADMFAFEEIEGLSADMSLAtelGAATTVRAALQ--SGDNITWTFDMGDGKSLSGPeaTVEHKYAKAGNCT 1232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 188 VVLTVTNDLGTKATT--TLNYSVSAAAGAPSTPVisANNTTVLPNAAVTFNASAqdslpLTYSWDFGDGTTGT----GAS 261
Cdd:TIGR00864 1233 VNIGAANAAGHGARIihVEVFVFEVAGIEPAACI--GEHADANFRARVSGNAAH-----YLFDWSFGDGSPNEthhgCPG 1305
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2037276277 262 VQKSYTAAGTYSVVVTATNTQNKStkSAATQVTVMQAVSN 301
Cdd:TIGR00864 1306 ISHNFRGNGTFPLALTISSGVNKA--HFFTQICVEPELGK 1343
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
50-376 |
1.89e-15 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 81.24 E-value: 1.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 50 PVMYTGRSVSLSATGTSSAN-LALTYSWdfgdSTAAGTGVT-SAHTFAKAGTYTVKVTATD--------TNGTKASASGT 119
Cdd:NF038112 1196 QTVLERTTVTLNGSGSFDPDgDPLTYAW----TQVSGPAVTlTGADTATPSFTAPEVTADTvltfqlvvSDGTKTSAPDT 1271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 120 VTI-VDAVLTAPTITPSVASSIA-GNAVTFTGASSDPSGGKLTYSWDFGDGSKDT---GTTVSHSFA----TAGTYAVVL 190
Cdd:NF038112 1272 VTVlVRNVNRAPVAVAGAPATVDeRSTVTLDGSGTDADGDALTYAWTQTSGPAVTltgATTATATFTapevTADTQLTFT 1351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 191 TVTNDLGTKATTTLNYSVSAAAGAPStpVISANNTTVLPNAAVTFNASAQD--SLPLTYSWDFGDGT--TGTGA------ 260
Cdd:NF038112 1352 LTVSDGTASATDTVTVTVRNVNRAPV--ANAGADQTVDERSTVTLSGSATDpdGDALTYAWTQTAGPtvTLTGAdtatas 1429
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 261 ------------SVQKSYTAAGTYS----VVVTATNTQNKSTKSAATQVTVMQAVSNALAPSCSGAGcsaSSATTYAGSG 324
Cdd:NF038112 1430 ftapevaadtelTFQLTVSADGQASadvtVTVTVRNVNRAPVAHAGESITVDEGSTVTLDASATDPD---GDTLTYAWTQ 1506
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2037276277 325 VGAWQYKNTGSVPASLNFAISGVKAGqvATLVFTNT-SDTSSLTAPGFGAVPV 376
Cdd:NF038112 1507 VAGPSVTLTGADSAKLTFTAPEVSAD--TTLTFSLTvTDGSGSSGPVVVTVTV 1557
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
129-202 |
2.61e-15 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 71.53 E-value: 2.61e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2037276277 129 APTITPSVASSIA-GNAVTFTG-ASSDPSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATT 202
Cdd:pfam18911 3 APVADAGGDRIVAeGETVTFDAsASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNST 78
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
55-327 |
7.93e-14 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 75.85 E-value: 7.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 55 GRSVSLSATGTSSANLALTYSWdfgdSTAAGTGVTSAHTFAKAGTYTVKVTATDTNGT--------KASASGTVTI-VDA 125
Cdd:NF038112 1296 RSTVTLDGSGTDADGDALTYAW----TQTSGPAVTLTGATTATATFTAPEVTADTQLTftltvsdgTASATDTVTVtVRN 1371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 126 VLTAPTIT-PSVASSIAGNAVTFTGASSDPSGGKLTYSWDFGDGSKDT---GTTVSHSF-----ATAGTYAVVLTVTNDL 196
Cdd:NF038112 1372 VNRAPVANaGADQTVDERSTVTLSGSATDPDGDALTYAWTQTAGPTVTltgADTATASFtapevAADTELTFQLTVSADG 1451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 197 GTKATTTLNYSVSAAAGApstPVISANNT-TVLPNAAVTFNASAQDSL--PLTYSWDFGDGT--TGTGASVQKSYTAAG- 270
Cdd:NF038112 1452 QASADVTVTVTVRNVNRA---PVAHAGESiTVDEGSTVTLDASATDPDgdTLTYAWTQVAGPsvTLTGADSAKLTFTAPe 1528
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2037276277 271 -------TYSVVVTATntqnkSTKSAATQVTVmqAVSNAlAPSCSGAGCSAssattyAGSGVGA 327
Cdd:NF038112 1529 vsadttlTFSLTVTDG-----SGSSGPVVVTV--TVKNV-NRAPDGGGCSS------TGGSPGG 1578
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
130-203 |
5.85e-13 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 64.78 E-value: 5.85e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2037276277 130 PTITPSVASSIAGNAVTFTGASSDpSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATTT 203
Cdd:smart00089 2 ADVSASPTVGVAGESVTFTATSSD-DGSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATV 74
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
42-122 |
1.44e-09 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 55.20 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 42 VSISTSGLPVMYTGRSVSLSATGTSSANlALTYSWDFGDSTAAGTGVTSA-HTFAKAGTYTVKVTATDTNGTKASASGTV 120
Cdd:cd00146 1 PTASVSAPPVAELGASVTFSASDSSGGS-IVSYKWDFGDGEVSSSGEPTVtHTYTKPGTYTVTLTVTNAVGSSSTKTTTV 79
|
..
gi 2037276277 121 TI 122
Cdd:cd00146 80 VV 81
|
|
| COG3291 |
COG3291 |
Uncharacterized conserved protein, PKD repeat domain [Function unknown]; |
132-385 |
4.18e-08 |
|
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
Pssm-ID: 442520 [Multi-domain] Cd Length: 333 Bit Score: 55.83 E-value: 4.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 132 ITPSVASSIAGNAVTFTGASSdpsGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATTTLNYSVSAA 211
Cdd:COG3291 1 FTATPTSGCAPLTVQFTDTSS---GNATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTITVGAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 212 AGAPSTPVISANNTTVLPNAAVTFNASAQDSLPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAAT 291
Cdd:COG3291 78 NPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 292 QVTVMQAVSNALAPSCSGAGCSASSATTYAGSGVGAWQYKNTGSVPASLNFAISGVKAGQVATLVFTNTSDTSSLTAPGF 371
Cdd:COG3291 158 SVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTG 237
|
250
....*....|....
gi 2037276277 372 GAVPVAIPAASTGA 385
Cdd:COG3291 238 ISTGDAGTPGTNTV 251
|
|
| COG3291 |
COG3291 |
Uncharacterized conserved protein, PKD repeat domain [Function unknown]; |
220-549 |
1.53e-05 |
|
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
Pssm-ID: 442520 [Multi-domain] Cd Length: 333 Bit Score: 48.13 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 220 ISANNTTVLPNAAVTFNASAQDSlPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAAT-QVTVMQA 298
Cdd:COG3291 1 FTATPTSGCAPLTVQFTDTSSGN-ATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTiTVGAPNP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 299 VSNALAPSCSGAGCSASSATTYAGSGVGAWQYKNTGSVPASLNFAISGVKAGQVATLVFTNTSDTSSLTAPGFGAVPVAI 378
Cdd:COG3291 80 GVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 379 PAASTGALSLNMQALNRHAQMDTAHQSMHQRNHDLIQQMRAKPATIRAAGVKAANVPPVRAVAVGDTKVWVDTYDSANPV 458
Cdd:COG3291 160 STTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGIS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 459 SYTLKVAQICKLKTGRNAVIWGDPNGGATAADLLALANTFCSNGGAGTAGFDALTDIMGDAYGTKSYSNTIGDTNGLLDI 538
Cdd:COG3291 240 TGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNVSTTADVTGGTATLAVSSTLT 319
|
330
....*....|.
gi 2037276277 539 NVVVPNVPSTT 549
Cdd:COG3291 320 TNDTTGSSSTG 330
|
|
| ser_rich_anae_1 |
NF033849 |
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
39-323 |
1.14e-04 |
|
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.
Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 45.77 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 39 TVSVSISTSgLPVMYTGrsvslsATGTSSANlaltyswDFGDSTAAGTGVTSAHTFAKAGTYTVKV----TATDTNGTKA 114
Cdd:NF033849 218 QKSISFGVS-LPMMYAA------NLGQSAGT-------GYGESVGHSTSQGQSHSVGTSESHSVGTsqsqSHTTGHGSTR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 115 SASGTVTIVDAVLTAPTITPSVASSIaGNAVTFTGASSDPSGG--KLTYSWDFGDGskdTGTTVSHSFATAGTYAVVLTV 192
Cdd:NF033849 284 GWSHTQSTSESESTGQSSSVGTSESQ-SHGTTEGTSTTDSSSHsqSSSYNVSSGTG---VSSSHSDGTSQSTSISHSESS 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 193 TNDLGTKATTTLN--YSVSAAAGAPSTPVISANNTTVLPNAAVTFNASAQdSLPLTYSWDFGDGTTGTGASVQKSYTAAG 270
Cdd:NF033849 360 SESTGTSVGHSTSssVSSSESSSRSSSSGVSGGFSGGIAGGGVTSEGLGA-SQGGSEGWGSGDSVQSVSQSYGSSSSTGT 438
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2037276277 271 TYSVVVT---ATNTQNKSTKSAATQVTVMQAVSNALAPSCS-GAGCSASSATTYAGS 323
Cdd:NF033849 439 SSGHSDSsshSTSSGQADSVSQGTSWSEGTGTSQGQSVGTSeSWSTSQSETDSVGDS 495
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Peptidase_M30 |
pfam10460 |
Peptidase M30; This family contains the metallopeptidase hyicolysin. Hyicolysin has a zinc ion ... |
498-821 |
1.49e-40 |
|
Peptidase M30; This family contains the metallopeptidase hyicolysin. Hyicolysin has a zinc ion which is liganded by two histidine and one glutamate residue.
Pssm-ID: 431298 Cd Length: 369 Bit Score: 153.55 E-value: 1.49e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 498 FCSNGGAgtagFDALTDIMGDAYGTKSYSNTIGDTNGLLDInVVVPNVPSTTKWG--GYFWGGNNFLKTAfPSTKDSNEA 575
Cdd:pfam10460 47 FANSGGI----YDMLVNVGGPVWGPNSYGTMIPGTGQPIDI-VILNFDHNGQPFGtvGYFWSMNNFKKSA-GQAQNSNES 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 576 LVFFVNGQQVS----QALNYYKSTLMHEAVHMINFYQRAFVLDT--AHDTWLEETTAMMGEDILAKTIFGGsYNEMTQVR 649
Cdd:pfam10460 121 ISLYLDSETLYlggaSGMQSMLTTMAHEGTHMQNFYRRQVSMGAayAFDTWLEEMTAMMMEDFASHDIDPT-YNAIRDLR 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 650 IPQYLRTGGG---VSYVNWTNL--SSDSYAFGGAFGAFINRKYGLSMFKKIVTDCNDGktvngvkvtSYACMDTLIKGV- 723
Cdd:pfam10460 200 FPDYYRYGGGsynCNLTTWTPFgaSCESYSVSGSLGGFLNRQLGLAFYKDLLTRATTG---------SKTVLDQAIRAAq 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 724 GGVGMGDELAKFGISLWGNTPASALPSGLGFPQRTvDGVF--DAIDVATVVKSL--KITAKSPATMVPTSHYFAQETIAA 799
Cdd:pfam10460 271 PGWTFEQALRNFKATTTALLPAASAPAGFGFPGRT-DGVFtlPQIDPSLPAYAAlrKLPASAPATLQAYGTYPVVRSDVS 349
|
330 340
....*....|....*....|..
gi 2037276277 800 GAtnYSKSgVIVPAGATLHIMV 821
Cdd:pfam10460 350 GT--YSET-VRVPAGATLSVVV 368
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
35-301 |
2.20e-18 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 90.91 E-value: 2.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 35 APLPTVSVSISTSglpVMYTGRSVSLSATGTSSANlALTYSWDFGDSTAAGTG--VTSAHTFAKAGTYTVKVTATDTngt 112
Cdd:TIGR00864 1085 AILPRVAIGTEDG---LLLAGKPADFEAHPLPSPG-GIHYEWDFGDGSALLQGrqPAAAHTFAKRGPFHVCLEVNNT--- 1157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 113 kasASGTVTIVDAVLTAPTITPSVASSIA---GNAVTFTGASSdpSGGKLTYSWDFGDGSKDTGT--TVSHSFATAGTYA 187
Cdd:TIGR00864 1158 ---ISGAAACADMFAFEEIEGLSADMSLAtelGAATTVRAALQ--SGDNITWTFDMGDGKSLSGPeaTVEHKYAKAGNCT 1232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 188 VVLTVTNDLGTKATT--TLNYSVSAAAGAPSTPVisANNTTVLPNAAVTFNASAqdslpLTYSWDFGDGTTGT----GAS 261
Cdd:TIGR00864 1233 VNIGAANAAGHGARIihVEVFVFEVAGIEPAACI--GEHADANFRARVSGNAAH-----YLFDWSFGDGSPNEthhgCPG 1305
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2037276277 262 VQKSYTAAGTYSVVVTATNTQNKStkSAATQVTVMQAVSN 301
Cdd:TIGR00864 1306 ISHNFRGNGTFPLALTISSGVNKA--HFFTQICVEPELGK 1343
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
73-280 |
4.38e-17 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 86.67 E-value: 4.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 73 TYSWDFGDSTAAGT---GVTSAHTFAKAGTYTVKVTATDtNGTKASASGTVTIvdavltaptITPSVASSIAGNAVTFTG 149
Cdd:TIGR00864 1372 RYEWDFGGEEAAPLpaaGAEVTFIYNDPGCYLVTVAASN-NISAANDSALIEV---------LEPVGATSFKHNGSHGNN 1441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 150 A--------SSDPSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGtKATTTLNYSVSAAAgapSTPVIS 221
Cdd:TIGR00864 1442 LelgqpylfSAFGRARNASYLWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVG-KNEATLNVAVKARV---RGLTIN 1517
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2037276277 222 ANNTTVLPNAAVTFNASAQDSLPLTYSWDFGDGTTGTGASVQKSYT--AAGTYSVVVTATN 280
Cdd:TIGR00864 1518 ASLTNVPLNGSVHFEAHLDAGDDVRFSWILCDHCTPIFGGNTIFYTfrSVGTFNIIVTAEN 1578
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
44-297 |
7.12e-16 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 82.82 E-value: 7.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 44 ISTSGLP-VMYTGRSVSLSATGTSSANLALTYSWDFGD--------------------STAAGTGVTS--AHTFAKAGTY 100
Cdd:TIGR00864 983 LQVKGVPaVLPPGATLALTAGVLIDMAVEAAFLWSFGDgeqalfefkppynesfpcpdPSPAQVLLEHnvMHIYAAPGEY 1062
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 101 TVKVTATdtNGTKASASGTVTIVDAVLTAPTITPSVASSIAGNAVTFTgASSDPSGGKLTYSWDFGDGS---KDTGTTVS 177
Cdd:TIGR00864 1063 LATVLAS--NAFENISQQINMSVRAILPRVAIGTEDGLLLAGKPADFE-AHPLPSPGGIHYEWDFGDGSallQGRQPAAA 1139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 178 HSFATAGTYAVVLTVTNDLGTKATTTLNYSVSAAAGapstpvISANNTT-VLPNAAVTFNASAQDSLPLTYSWDFGDGT- 255
Cdd:TIGR00864 1140 HTFAKRGPFHVCLEVNNTISGAAACADMFAFEEIEG------LSADMSLaTELGAATTVRAALQSGDNITWTFDMGDGKs 1213
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2037276277 256 -TGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAATQVTVMQ 297
Cdd:TIGR00864 1214 lSGPEATVEHKYAKAGNCTVNIGAANAAGHGARIIHVEVFVFE 1256
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
50-376 |
1.89e-15 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 81.24 E-value: 1.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 50 PVMYTGRSVSLSATGTSSAN-LALTYSWdfgdSTAAGTGVT-SAHTFAKAGTYTVKVTATD--------TNGTKASASGT 119
Cdd:NF038112 1196 QTVLERTTVTLNGSGSFDPDgDPLTYAW----TQVSGPAVTlTGADTATPSFTAPEVTADTvltfqlvvSDGTKTSAPDT 1271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 120 VTI-VDAVLTAPTITPSVASSIA-GNAVTFTGASSDPSGGKLTYSWDFGDGSKDT---GTTVSHSFA----TAGTYAVVL 190
Cdd:NF038112 1272 VTVlVRNVNRAPVAVAGAPATVDeRSTVTLDGSGTDADGDALTYAWTQTSGPAVTltgATTATATFTapevTADTQLTFT 1351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 191 TVTNDLGTKATTTLNYSVSAAAGAPStpVISANNTTVLPNAAVTFNASAQD--SLPLTYSWDFGDGT--TGTGA------ 260
Cdd:NF038112 1352 LTVSDGTASATDTVTVTVRNVNRAPV--ANAGADQTVDERSTVTLSGSATDpdGDALTYAWTQTAGPtvTLTGAdtatas 1429
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 261 ------------SVQKSYTAAGTYS----VVVTATNTQNKSTKSAATQVTVMQAVSNALAPSCSGAGcsaSSATTYAGSG 324
Cdd:NF038112 1430 ftapevaadtelTFQLTVSADGQASadvtVTVTVRNVNRAPVAHAGESITVDEGSTVTLDASATDPD---GDTLTYAWTQ 1506
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2037276277 325 VGAWQYKNTGSVPASLNFAISGVKAGqvATLVFTNT-SDTSSLTAPGFGAVPV 376
Cdd:NF038112 1507 VAGPSVTLTGADSAKLTFTAPEVSAD--TTLTFSLTvTDGSGSSGPVVVTVTV 1557
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
129-202 |
2.61e-15 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 71.53 E-value: 2.61e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2037276277 129 APTITPSVASSIA-GNAVTFTG-ASSDPSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATT 202
Cdd:pfam18911 3 APVADAGGDRIVAeGETVTFDAsASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNST 78
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
218-295 |
4.85e-14 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 68.07 E-value: 4.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 218 PVISAN-NTTVLPNAAVTFNASAQ---DSLPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAATQV 293
Cdd:pfam18911 4 PVADAGgDRIVAEGETVTFDASASddpDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTATDTV 83
|
..
gi 2037276277 294 TV 295
Cdd:pfam18911 84 TV 85
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
55-327 |
7.93e-14 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 75.85 E-value: 7.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 55 GRSVSLSATGTSSANLALTYSWdfgdSTAAGTGVTSAHTFAKAGTYTVKVTATDTNGT--------KASASGTVTI-VDA 125
Cdd:NF038112 1296 RSTVTLDGSGTDADGDALTYAW----TQTSGPAVTLTGATTATATFTAPEVTADTQLTftltvsdgTASATDTVTVtVRN 1371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 126 VLTAPTIT-PSVASSIAGNAVTFTGASSDPSGGKLTYSWDFGDGSKDT---GTTVSHSF-----ATAGTYAVVLTVTNDL 196
Cdd:NF038112 1372 VNRAPVANaGADQTVDERSTVTLSGSATDPDGDALTYAWTQTAGPTVTltgADTATASFtapevAADTELTFQLTVSADG 1451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 197 GTKATTTLNYSVSAAAGApstPVISANNT-TVLPNAAVTFNASAQDSL--PLTYSWDFGDGT--TGTGASVQKSYTAAG- 270
Cdd:NF038112 1452 QASADVTVTVTVRNVNRA---PVAHAGESiTVDEGSTVTLDASATDPDgdTLTYAWTQVAGPsvTLTGADSAKLTFTAPe 1528
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2037276277 271 -------TYSVVVTATntqnkSTKSAATQVTVmqAVSNAlAPSCSGAGCSAssattyAGSGVGA 327
Cdd:NF038112 1529 vsadttlTFSLTVTDG-----SGSSGPVVVTV--TVKNV-NRAPDGGGCSS------TGGSPGG 1578
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
63-300 |
1.82e-13 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 74.73 E-value: 1.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 63 TGTSSANLaltYSWDFGDSTAAGT-----GVTsaHTFAKAGTYTVKVTATdtNGTKASASGTVTIVDAVLTAPTITPSVA 137
Cdd:TIGR00864 1279 SGNAAHYL---FDWSFGDGSPNEThhgcpGIS--HNFRGNGTFPLALTIS--SGVNKAHFFTQICVEPELGKISLQAEKQ 1351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 138 SSIAGNAVTFTGASSDPSggKLTYSWDFGdGSKD-----TGTTVSHSFATAGTYAVVLTVTNDLgTKATTTLNYSVSAAA 212
Cdd:TIGR00864 1352 FFALGDEAQFQACAEPEF--NYRYEWDFG-GEEAaplpaAGAEVTFIYNDPGCYLVTVAASNNI-SAANDSALIEVLEPV 1427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 213 GAPSTPVISANNTTVLPNAAVTFNASAQDSlPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKStkSAATQ 292
Cdd:TIGR00864 1428 GATSFKHNGSHGNNLELGQPYLFSAFGRAR-NASYLWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVGKN--EATLN 1504
|
....*...
gi 2037276277 293 VTVMQAVS 300
Cdd:TIGR00864 1505 VAVKARVR 1512
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
130-203 |
5.85e-13 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 64.78 E-value: 5.85e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2037276277 130 PTITPSVASSIAGNAVTFTGASSDpSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATTT 203
Cdd:smart00089 2 ADVSASPTVGVAGESVTFTATSSD-DGSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATV 74
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
218-294 |
1.20e-12 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 64.01 E-value: 1.20e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2037276277 218 PVISANNTTVLPNAAVTFNASAQDSL-PLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAATQVT 294
Cdd:smart00089 2 ADVSASPTVGVAGESVTFTATSSDDGsIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVVVQ 79
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
38-311 |
1.32e-12 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 72.04 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 38 PTVSVSISTSGLPVMyTGRSVSLSATGTSSANLALTYSWDFGDSTAAGTGVTSaHTFAKAGTYTVKVTATDTNGtkaSAS 117
Cdd:TIGR00864 1696 PAGNLMLAASDNPAA-VNALINLSAELAEGSGLQYRWFLEEGDDLETSEPFMS-HSFPSAGLHLVTMKAFNELG---SAN 1770
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 118 GTVTI-VDAVLTAPTITPSVASS----IAGNAVTFTGASSdpSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTV 192
Cdd:TIGR00864 1771 ASEEVdVQEPISGLKIRAADAGEqnffAADSSVCFQGELA--TGTNVSWCWAIDGGSSKMGKHACMTFPDAGTFAIRLNA 1848
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 193 TNDLGTKATTtlnYSVSAAAGAPSTpVISANNTTVLPNAAVTFNASAQDSLPLTYSWDFGDGTT---GTGASVQKSYTAA 269
Cdd:TIGR00864 1849 SNAVSGKSAS---REFFAEEPIFGL-ELKASKKIAAIGEKVEFQILLAAGSAVNFRLQIGGAAPevlQPGPRFSHSFPRV 1924
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2037276277 270 GTYSVVVTATNtqNKSTKSAATQVTVMQAVSNALAPSCSGAG 311
Cdd:TIGR00864 1925 DDHMVNLRAKN--EVSCAQANLHIEVLEAVRGLQIPDCCAAG 1964
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
55-123 |
1.67e-11 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 60.75 E-value: 1.67e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 55 GRSVSLSATGTSSANL-ALTYSWDFGDSTAAgTGVTSAHTFAKAGTYTVKVTATDTNGTkASASGTVTIV 123
Cdd:pfam18911 17 GETVTFDASASDDPDGdILSYRWDFGDGTTA-TGANVSHTYAAPGTYTVTLTVTDDSGA-SNSTATDTVT 84
|
|
| PKD |
pfam00801 |
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ... |
220-281 |
2.10e-10 |
|
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.
Pssm-ID: 395646 [Multi-domain] Cd Length: 70 Bit Score: 57.40 E-value: 2.10e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2037276277 220 ISANNTTVLPNAAVTFNASAQDSLPLTYSWDFGD--GTTGTGASVQKSYTAAGTYSVVVTATNT 281
Cdd:pfam00801 1 VSASGTVVAAGQPVTFTATLADGSNVTYTWDFGDspGTSGSGPTVTHTYLSPGTYTVTLTASNA 64
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
54-299 |
3.84e-10 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 63.95 E-value: 3.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 54 TGRSVSLSATGTSSANLalTYSW------DFGDSTAAGTGVTSAHTFAKAGTYTVKVTATDTNGtKASASGTVTIVDA-- 125
Cdd:TIGR00864 1622 TNHTVQFHAGFKDGTNL--SFSWnaildnEPDGPAFAGSGKGAKLNPLEAGPCDIFLQAANLLG-QATADCTIDFLEPag 1698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 126 -VLTAPTITPSVASSIagnaVTFTGASSDPSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATTTL 204
Cdd:TIGR00864 1699 nLMLAASDNPAAVNAL----INLSAELAEGSGLQYRWFLEEGDDLETSEPFMSHSFPSAGLHLVTMKAFNELGSANASEE 1774
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 205 NYSVSAAAGAPSTPVISANNTTVLPNAAVTFNASAQDSLPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNtqNK 284
Cdd:TIGR00864 1775 VDVQEPISGLKIRAADAGEQNFFAADSSVCFQGELATGTNVSWCWAIDGGSSKMGKHACMTFPDAGTFAIRLNASN--AV 1852
|
250
....*....|....*
gi 2037276277 285 STKSAATQVTVMQAV 299
Cdd:TIGR00864 1853 SGKSASREFFAEEPI 1867
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
36-280 |
5.44e-10 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 63.56 E-value: 5.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 36 PLPTVSVSISTSGLPVMYTGRSVSLSATGTSSAnlaLTYSWDFGDST-AAGTGVTsaHTFAKAGTYTVKVTATDTNGtKA 114
Cdd:TIGR00864 1426 PVGATSFKHNGSHGNNLELGQPYLFSAFGRARN---ASYLWDFGDGGlLEGPEIL--HAFNSPGDFNIRLAAANEVG-KN 1499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 115 SASGTVTIVDAVlTAPTITPSVASSIAGNAVTFTgaSSDPSGGKLTYSWDFGDGSKDT--GTTVSHSFATAGTYAVVLTV 192
Cdd:TIGR00864 1500 EATLNVAVKARV-RGLTINASLTNVPLNGSVHFE--AHLDAGDDVRFSWILCDHCTPIfgGNTIFYTFRSVGTFNIIVTA 1576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 193 TNDLGTKATTTLNYS---------VSAAAGAPSTPVISANNTTVLPNAAVTFNASAQDSLPLTYSWDF-------GDGTT 256
Cdd:TIGR00864 1577 ENDVGAAQASIFLFVlqeieglqiLGETAEGGGGGVQELDGCYFETNHTVQFHAGFKDGTNLSFSWNAildnepdGPAFA 1656
|
250 260
....*....|....*....|....
gi 2037276277 257 GTGASVQKSYTAAGTYSVVVTATN 280
Cdd:TIGR00864 1657 GSGKGAKLNPLEAGPCDIFLQAAN 1680
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
42-122 |
1.44e-09 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 55.20 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 42 VSISTSGLPVMYTGRSVSLSATGTSSANlALTYSWDFGDSTAAGTGVTSA-HTFAKAGTYTVKVTATDTNGTKASASGTV 120
Cdd:cd00146 1 PTASVSAPPVAELGASVTFSASDSSGGS-IVSYKWDFGDGEVSSSGEPTVtHTYTKPGTYTVTLTVTNAVGSSSTKTTTV 79
|
..
gi 2037276277 121 TI 122
Cdd:cd00146 80 VV 81
|
|
| PKD |
pfam00801 |
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ... |
132-197 |
2.78e-09 |
|
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.
Pssm-ID: 395646 [Multi-domain] Cd Length: 70 Bit Score: 53.93 E-value: 2.78e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2037276277 132 ITPSVASSIAGNAVTFTGASSDPSGgkLTYSWDFGD--GSKDTGTTVSHSFATAGTYAVVLTVTNDLG 197
Cdd:pfam00801 1 VSASGTVVAAGQPVTFTATLADGSN--VTYTWDFGDspGTSGSGPTVTHTYLSPGTYTVTLTASNAVG 66
|
|
| PKD |
pfam00801 |
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ... |
44-111 |
9.16e-09 |
|
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.
Pssm-ID: 395646 [Multi-domain] Cd Length: 70 Bit Score: 52.77 E-value: 9.16e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2037276277 44 ISTSGLPVMyTGRSVSLSATGTSSANLalTYSWDFGDSTAA-GTGVTSAHTFAKAGTYTVKVTATDTNG 111
Cdd:pfam00801 1 VSASGTVVA-AGQPVTFTATLADGSNV--TYTWDFGDSPGTsGSGPTVTHTYLSPGTYTVTLTASNAVG 66
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
46-123 |
9.69e-09 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 52.84 E-value: 9.69e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2037276277 46 TSGLPVMYTGRSVSLSATGTSSANlALTYSWDFGDSTAAgTGVTSAHTFAKAGTYTVKVTATDTNGTkASASGTVTIV 123
Cdd:smart00089 5 SASPTVGVAGESVTFTATSSDDGS-IVSYTWDFGDGTSS-TGPTVTHTYTKPGTYTVTLTVTNAVGS-ASATVTVVVQ 79
|
|
| COG3291 |
COG3291 |
Uncharacterized conserved protein, PKD repeat domain [Function unknown]; |
132-385 |
4.18e-08 |
|
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
Pssm-ID: 442520 [Multi-domain] Cd Length: 333 Bit Score: 55.83 E-value: 4.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 132 ITPSVASSIAGNAVTFTGASSdpsGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATTTLNYSVSAA 211
Cdd:COG3291 1 FTATPTSGCAPLTVQFTDTSS---GNATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTITVGAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 212 AGAPSTPVISANNTTVLPNAAVTFNASAQDSLPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAAT 291
Cdd:COG3291 78 NPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 292 QVTVMQAVSNALAPSCSGAGCSASSATTYAGSGVGAWQYKNTGSVPASLNFAISGVKAGQVATLVFTNTSDTSSLTAPGF 371
Cdd:COG3291 158 SVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTG 237
|
250
....*....|....
gi 2037276277 372 GAVPVAIPAASTGA 385
Cdd:COG3291 238 ISTGDAGTPGTNTV 251
|
|
| COG3291 |
COG3291 |
Uncharacterized conserved protein, PKD repeat domain [Function unknown]; |
66-381 |
5.31e-08 |
|
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
Pssm-ID: 442520 [Multi-domain] Cd Length: 333 Bit Score: 55.83 E-value: 5.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 66 SSANLALTYSWDFGDSTAAgTGVTSAHTFAKAGTYTVKVTATDTNGTKASASGTVTIVDAVLTAPTITPSVASSIAGNAV 145
Cdd:COG3291 19 TSSGNATSYEWDFGDGTTS-TEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 146 TFTGASSDPSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAVVLTVTNDLGTKATTTLNYSVSAAAGAPSTPVISANNT 225
Cdd:COG3291 98 NGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 226 TVLPNAAVTFNASAQDSLPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAATQVTVMQAVSNALAP 305
Cdd:COG3291 178 VTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGAN 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2037276277 306 SCSGAGCSASSATTYAGSGVGAWQYKNTGSVPASLNFAISGVKAGQVATLVFTNTSDTSSLTAPGFGAVPVAIPAA 381
Cdd:COG3291 258 TAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNVSTTADVTGGTATLAVSSTLTTNDTTGSSSTGTVF 333
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
132-208 |
7.86e-08 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 50.19 E-value: 7.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 132 ITPSVASSIAGNAVTFTGASSDPSGGK-LTYSWDFGDGSKDT--GTTVSHSFATAGTYAVVLTVTNDLGTKATTTLNYSV 208
Cdd:cd00146 2 TASVSAPPVAELGASVTFSASDSSGGSiVSYKWDFGDGEVSSsgEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
59-297 |
8.04e-08 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 56.24 E-value: 8.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 59 SLSATGTSSANLALTYSwdfGDSTAA-GTGVTSAHTFAKAGTYTVKVTATDtNGTKASASGTVTIVDAVlTAPTITPSVA 137
Cdd:TIGR00864 1888 QILLAAGSAVNFRLQIG---GAAPEVlQPGPRFSHSFPRVDDHMVNLRAKN-EVSCAQANLHIEVLEAV-RGLQIPDCCA 1962
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 138 SSIA-GNAVTFTGASSdpSGGKLTYSWDFG--DGSKDT-----GTTVSHSFATAGTYAVVLTVTNDLGTKATTTlnysVS 209
Cdd:TIGR00864 1963 AGIAtGEEKNFTANVQ--RGKPVAFAWTFDlhHLHGDSlvihmGKDVSYTAEAAGLLEIQLGAFNALGAENITL----QL 2036
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 210 AAAGAPSTPVISANNTTVLPNAAVTFNA-SAQDSLPLTYSWDFGDGTTG---TGASVQKSYTAAGTYSVVVTATNTQNKS 285
Cdd:TIGR00864 2037 EAQDALMDAALQAGPQDCFTNKMAQFEAaTSPKPNFMACHWDFGDGSAGqdtDEPRAEHEYLHPGDYRVQVNASNLVSFF 2116
|
250
....*....|..
gi 2037276277 286 TKSAATQVTVMQ 297
Cdd:TIGR00864 2117 SAHAEINVQVLA 2128
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
219-295 |
1.47e-07 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 49.42 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 219 VISANNTTVLPNAAVTFNASAQDSL-PLTYSWDFGDGT--TGTGASVQKSYTAAGTYSVVVTATNTQNKSTkSAATQVTV 295
Cdd:cd00146 3 ASVSAPPVAELGASVTFSASDSSGGsIVSYKWDFGDGEvsSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSS-TKTTTVVV 81
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
99-295 |
4.08e-06 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 50.14 E-value: 4.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 99 TYTVKVTATDTNGTKASASGTVTIVDAVLTAPTIT--PSVASSIAGNAVTFTGASSDPSGGKLTYSWDFGDGSKDTGTTV 176
Cdd:COG3469 1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTaaTATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 177 SHSFATAGTYAVVLTVTNDLGTKATTTLNYSV---SAAAGAPSTPVISANNTTVLPNAAVTFNASAQDSLPLTYSWDFGD 253
Cdd:COG3469 81 TATAAAAAATSTSATLVATSTASGANTGTSTVtttSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETAT 160
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2037276277 254 GTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAATQVTV 295
Cdd:COG3469 161 GGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTA 202
|
|
| COG3291 |
COG3291 |
Uncharacterized conserved protein, PKD repeat domain [Function unknown]; |
220-549 |
1.53e-05 |
|
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
Pssm-ID: 442520 [Multi-domain] Cd Length: 333 Bit Score: 48.13 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 220 ISANNTTVLPNAAVTFNASAQDSlPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAAT-QVTVMQA 298
Cdd:COG3291 1 FTATPTSGCAPLTVQFTDTSSGN-ATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTiTVGAPNP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 299 VSNALAPSCSGAGCSASSATTYAGSGVGAWQYKNTGSVPASLNFAISGVKAGQVATLVFTNTSDTSSLTAPGFGAVPVAI 378
Cdd:COG3291 80 GVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 379 PAASTGALSLNMQALNRHAQMDTAHQSMHQRNHDLIQQMRAKPATIRAAGVKAANVPPVRAVAVGDTKVWVDTYDSANPV 458
Cdd:COG3291 160 STTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGIS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 459 SYTLKVAQICKLKTGRNAVIWGDPNGGATAADLLALANTFCSNGGAGTAGFDALTDIMGDAYGTKSYSNTIGDTNGLLDI 538
Cdd:COG3291 240 TGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNVSTTADVTGGTATLAVSSTLT 319
|
330
....*....|.
gi 2037276277 539 NVVVPNVPSTT 549
Cdd:COG3291 320 TNDTTGSSSTG 330
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
127-308 |
1.63e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 48.93 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 127 LTAPTItPSVASSIAGNAVTfTGASSDpSGGKLTYSWDFGDGSKD-----------------------TGTTVSHSFATA 183
Cdd:TIGR00864 983 LQVKGV-PAVLPPGATLALT-AGVLID-MAVEAAFLWSFGDGEQAlfefkppynesfpcpdpspaqvlLEHNVMHIYAAP 1059
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 184 GTYAVVLTVTNdlgtkATTTLNYSVSAAAGAPSTPV-ISANNTTVLPNAAVTFNASaqdSLP----LTYSWDFGDGT--- 255
Cdd:TIGR00864 1060 GEYLATVLASN-----AFENISQQINMSVRAILPRVaIGTEDGLLLAGKPADFEAH---PLPspggIHYEWDFGDGSall 1131
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2037276277 256 TGTGASVQKSYTAAGTYSVVVTATNTqnKSTKSAATQVTVMQAVSNALAPSCS 308
Cdd:TIGR00864 1132 QGRQPAAAHTFAKRGPFHVCLEVNNT--ISGAAACADMFAFEEIEGLSADMSL 1182
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
11-218 |
5.43e-05 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 46.67 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 11 VSTLSLAALTACGGGGGGDSTTAPAPlPTVSVSISTSGLPVMYTGRSVSLSATGTSSANLALTYSWDFGDSTAAGTGVTS 90
Cdd:COG3469 12 AGGASATAVTLLGAAATAASVTLTAA-TATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAAT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 91 AHTFAKAGTYTvkvTATDTNGTKASASGTVTIVDAVLTAPTITPSVASSIAGNAVTFTGASSDPSGGKLTYSWDFGDGSK 170
Cdd:COG3469 91 STSATLVATST---ASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTS 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2037276277 171 DTGTTVSHSFATAGTYAVvlTVTNDLGTKATTTLNYSVSAAAGAPSTP 218
Cdd:COG3469 168 TTTTTTSASTTPSATTTA--TATTASGATTPSATTTATTTGPPTPGLP 213
|
|
| ser_rich_anae_1 |
NF033849 |
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
39-323 |
1.14e-04 |
|
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.
Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 45.77 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 39 TVSVSISTSgLPVMYTGrsvslsATGTSSANlaltyswDFGDSTAAGTGVTSAHTFAKAGTYTVKV----TATDTNGTKA 114
Cdd:NF033849 218 QKSISFGVS-LPMMYAA------NLGQSAGT-------GYGESVGHSTSQGQSHSVGTSESHSVGTsqsqSHTTGHGSTR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 115 SASGTVTIVDAVLTAPTITPSVASSIaGNAVTFTGASSDPSGG--KLTYSWDFGDGskdTGTTVSHSFATAGTYAVVLTV 192
Cdd:NF033849 284 GWSHTQSTSESESTGQSSSVGTSESQ-SHGTTEGTSTTDSSSHsqSSSYNVSSGTG---VSSSHSDGTSQSTSISHSESS 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 193 TNDLGTKATTTLN--YSVSAAAGAPSTPVISANNTTVLPNAAVTFNASAQdSLPLTYSWDFGDGTTGTGASVQKSYTAAG 270
Cdd:NF033849 360 SESTGTSVGHSTSssVSSSESSSRSSSSGVSGGFSGGIAGGGVTSEGLGA-SQGGSEGWGSGDSVQSVSQSYGSSSSTGT 438
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2037276277 271 TYSVVVT---ATNTQNKSTKSAATQVTVMQAVSNALAPSCS-GAGCSASSATTYAGS 323
Cdd:NF033849 439 SSGHSDSsshSTSSGQADSVSQGTSWSEGTGTSQGQSVGTSeSWSTSQSETDSVGDS 495
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
38-210 |
2.43e-04 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 45.07 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 38 PTVSVSISTSGLPVMYTGRSVSLSATGTSSANLAltYSWDF------GDSTAAGTGVTSAHTFAKAGTYTVKVTATdtNG 111
Cdd:TIGR00864 1951 AVRGLQIPDCCAAGIATGEEKNFTANVQRGKPVA--FAWTFdlhhlhGDSLVIHMGKDVSYTAEAAGLLEIQLGAF--NA 2026
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 112 TKASASGTVTIVDAVLTAPTITPSVASSIAGNAVTFTGASSdPSGGKLTYSWDFGDGS--KDTG-TTVSHSFATAGTYAV 188
Cdd:TIGR00864 2027 LGAENITLQLEAQDALMDAALQAGPQDCFTNKMAQFEAATS-PKPNFMACHWDFGDGSagQDTDePRAEHEYLHPGDYRV 2105
|
170 180
....*....|....*....|...
gi 2037276277 189 VLTVTNDLG-TKATTTLNYSVSA 210
Cdd:TIGR00864 2106 QVNASNLVSfFSAHAEINVQVLA 2128
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
33-441 |
7.05e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 43.40 E-value: 7.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 33 APAPLPTVSVSISTSGLPVMYTGRSVSLSATGTSSAN-LALTYSWDFGDSTAAGTGVTSAHTF----AKAGTYTVKVTAT 107
Cdd:COG4733 527 VPPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGaVAYEVEWRRDDGNWVSVPRTSGTSFevpgIYAGDYEVRVRAI 606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 108 DTNGTKasaSGTVTIVDAVLTAPTITPSVASSIagnavtftgaSSDPSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYA 187
Cdd:COG4733 607 NALGVS---SAWAASSETTVTGKTAPPPAPTGL----------TATGGLGGITLSWSFPVDADTLRTEIRYSTTGDWASA 673
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 188 VVLTVTN------DLGTKATTTLNYSVSA-----------AAGAPSTPVIS---------------------ANNTTVLP 229
Cdd:COG4733 674 TVAQALYpgntytLAGLKAGQTYYYRARAvdrsgnvsawwVSGQASADAAGildaitgqiletelgqeldaiIQNATVAE 753
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 230 NAAVTFNASAQDSLPLTYSWDFGDGTTGTGASVQKSYTAAGTYSVVVTATNTQNKSTKSAATQVTVMQAVSNALAPSCSG 309
Cdd:COG4733 754 VVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGVTAGTSGTTGAGDTAASTT 833
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 310 AGCSASSATTYAGSGVGAWQYKNTGSVPASlNFAISGVKAGQVATLVFTNTSDTSSLTAPGFGAVPVAIPAASTGALSLN 389
Cdd:COG4733 834 RVAAAVVLAGVVVYGDAIIESGNTGDIVAT-GDIASAAAGAVATTVSGTTAADVSAVADSTAASLTAIVIAATTIIDAIG 912
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 2037276277 390 MQALNRHAQMDTAHQSMHQRNHDLIQQMRAKPATIRAAGVKAANVPPVRAVA 441
Cdd:COG4733 913 DGTTREPAGDIGASGGAQGFAVTIVGSFDGAGAVATVDAGQSVVDGVGTAVE 964
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
12-139 |
9.29e-03 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 39.68 E-value: 9.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 12 STLSLAALTACGGGGGGDSTTAPAPLPTVSVSISTSGLPVMYTGRSVSLSATGTSSANLAL---TYSWDFGDSTA----- 83
Cdd:TIGR00864 146 SEANFACESLCSGPPPPPAAACRGPQLLEHIFPALPGAPIQGPHGPIASGQLAAFHAAAPLaptAMRWDFGDGSAevdaa 225
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2037276277 84 -AGTGVTSAHTFAKAGTYTVKVTATDTNGtKASASGTVTIVDAVLTAPTITPSVASS 139
Cdd:TIGR00864 226 gAGGTTAASHKYGHPGRYHVSAMGALGAG-KALAGGDVQVEAAPAALELHCPSLVQA 281
|
|
| AidA |
COG3468 |
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ... |
29-367 |
9.81e-03 |
|
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442691 [Multi-domain] Cd Length: 846 Bit Score: 39.54 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 29 DSTTAPAPLPTVSVSISTSGLPVMYTGRSVSLSATGTSSANLALTYSwDFGDSTAAGTGVTSAHTFAKAGTYTVKVTATD 108
Cdd:COG3468 110 SGNGGGGGGGGGGGGTGGGGGGGTGSAGGGGGGGGGGTGVGGTGAAA-AGGGTGSGGGGSGGGGGAGGGGGGGAGGSGGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 109 TNGTKASASGTVTIVDAVLTAPTITPSVASSIAGNAVTFTGASSDPSGGKLTYSWDFGDGSKDTGTTVSHSFATAGTYAV 188
Cdd:COG3468 189 GSTGSGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGLTGGGAAGTGGGGGGT 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 189 VLTVTNDLGTKA-TTTLNYSVSAAAGAPSTPVISANNTTVLPNAAVTFNASAQDSLPLTYSWDFGDGTTGTGASVQKSYT 267
Cdd:COG3468 269 GTGSGGGGGGGAnGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTTLNGAGS 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037276277 268 AAGTYSVVVTATNTQNKSTKSAATQVTVMQAVSNALAPSCSGAGCSASSATTYAGSGVGAWQYKNTGSVPASLNFAISGV 347
Cdd:COG3468 349 AGGGTGAALAGTGGSGSGGGGGGGSGGGGGAGGGGANTGSDGVGTGLTTGGTGNNGGGGVGGGGGGGLTLTGGTLTVNGN 428
|
330 340
....*....|....*....|.
gi 2037276277 348 KAGQVATLVF-TNTSDTSSLT 367
Cdd:COG3468 429 YTGNNGTLVLnTVLGDDNSPT 449
|
|
| |
