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Conserved domains on  [gi|2044745871|ref|WP_213427868|]
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MULTISPECIES: 3-hydroxyacyl-CoA dehydrogenase family protein [Paenibacillus]

Protein Classification

3-hydroxyacyl-CoA dehydrogenase family protein( domain architecture ID 11441205)

3-hydroxyacyl-CoA dehydrogenase (HCDH) family protein such as mitochondrial HCDH, which plays an essential role in the beta-oxidation of short chain fatty acids

CATH:  3.40.50.720|1.10.1040.10
EC:  1.1.1.-
Gene Ontology:  GO:0003857|GO:0006635|GO:0070403
PubMed:  3479790
SCOP:  4000107

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 58-243 1.07e-55

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 179.92  E-value: 1.07e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:COG1250    96 KQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVATAVAFARRLGK 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 EVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERY 217
Cdd:COG1250   176 TPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELADLVGLDTALAVLEVLYEALGDPRY 255

                         170       180
                  ....*....|....*....|....*.
gi 2044745871 218 RPAPLLRKLVLAGRLGRRSGQGFYSY 243
Cdd:COG1250   256 RPPPLLKKLVEAGRLGRKTGRGFYDY 281
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 58-243 1.07e-55

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 179.92  E-value: 1.07e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:COG1250    96 KQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVATAVAFARRLGK 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 EVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERY 217
Cdd:COG1250   176 TPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELADLVGLDTALAVLEVLYEALGDPRY 255

                         170       180
                  ....*....|....*....|....*.
gi 2044745871 218 RPAPLLRKLVLAGRLGRRSGQGFYSY 243
Cdd:COG1250   256 RPPPLLKKLVEAGRLGRKTGRGFYDY 281
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
58-251 7.37e-54

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 175.36  E-value: 7.37e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:PRK09260   96 KKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSDETVQVAKEVAEQMGK 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 EVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGeERY 217
Cdd:PRK09260  176 ETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLGLNFPMGPLELGDLVGLDTRLNNLKYLHETLG-EKY 254

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2044745871 218 RPAPLLRKLVLAGRLGRRSGQGFYSYEIGGERDG 251
Cdd:PRK09260  255 RPAPLLEKYVKAGRLGRKTGRGVYDYTNRENVPG 288
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 152-243 1.82e-35

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 121.94  E-value: 1.82e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 152 RILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERYRPAPLLRKLVLAGR 231
Cdd:pfam00725   6 RLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGYHILEVLAEEFGDRAYRPPPLLEKLVEAGR 85

                          90
                  ....*....|..
gi 2044745871 232 LGRRSGQGFYSY 243
Cdd:pfam00725  86 LGRKTGKGFYKY 97
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 48-253 8.94e-21

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 91.05  E-value: 8.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  48 MEVTNDDAAEKQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRG 127
Cdd:TIGR02441 419 IEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKDTLAS 498

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 128 LEELFRTLGKEVEIVEDEAGLVFPRILALIVNEAAFALMEGTaSAADIDtAMKLGTGYPHGPLEWADRIGLDDVLAVLRG 207
Cdd:TIGR02441 499 AVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGV-DPKKLD-KLTTKFGFPVGAATLADEVGVDVAEHVAED 576

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2044745871 208 LHRDLGeERYR--PAPLLRKLVLAGRLGRRSGQGFYSYEIG--GERDGNT 253
Cdd:TIGR02441 577 LGKAFG-ERFGggSAELLSELVKAGFLGRKSGKGIFIYQEGkkGSKKVNS 625
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 58-243 1.07e-55

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 179.92  E-value: 1.07e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:COG1250    96 KQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVATAVAFARRLGK 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 EVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERY 217
Cdd:COG1250   176 TPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELADLVGLDTALAVLEVLYEALGDPRY 255

                         170       180
                  ....*....|....*....|....*.
gi 2044745871 218 RPAPLLRKLVLAGRLGRRSGQGFYSY 243
Cdd:COG1250   256 RPPPLLKKLVEAGRLGRKTGRGFYDY 281
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
58-251 7.37e-54

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 175.36  E-value: 7.37e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:PRK09260   96 KKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSDETVQVAKEVAEQMGK 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 EVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGeERY 217
Cdd:PRK09260  176 ETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLGLNFPMGPLELGDLVGLDTRLNNLKYLHETLG-EKY 254

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2044745871 218 RPAPLLRKLVLAGRLGRRSGQGFYSYEIGGERDG 251
Cdd:PRK09260  255 RPAPLLEKYVKAGRLGRKTGRGVYDYTNRENVPG 288
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 65-243 5.54e-53

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 172.84  E-value: 5.54e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  65 MDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIVED 144
Cdd:PRK05808  104 LDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRGLATSDATHEAVEALAKKIGKTPVEVKN 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 145 EAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERYRPAPLLR 224
Cdd:PRK05808  184 APGFVVNRILIPMINEAIFVLAEGVATAEDIDEGMKLGCNHPIGPLALADLIGLDTCLAIMEVLYEGFGDSKYRPCPLLR 263

                         170
                  ....*....|....*....
gi 2044745871 225 KLVLAGRLGRRSGQGFYSY 243
Cdd:PRK05808  264 KMVAAGWLGRKTGRGFYDY 282
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 63-243 2.36e-51

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 169.14  E-value: 2.36e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  63 VRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIV 142
Cdd:PLN02545  103 SELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVEIIRGADTSDEVFDATKALAERFGKTVVCS 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 143 EDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERYRPAPL 222
Cdd:PLN02545  183 QDYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLGTNHPMGPLHLADFIGLDTCLSIMKVLHEGLGDSKYRPCPL 262

                         170       180
                  ....*....|....*....|.
gi 2044745871 223 LRKLVLAGRLGRRSGQGFYSY 243
Cdd:PLN02545  263 LVQYVDAGRLGRKSGRGVYHY 283
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 69-243 1.07e-43

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 149.39  E-value: 1.07e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  69 LGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIVEDEAGL 148
Cdd:PRK07530  109 LKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIATDEATFEAAKEFVTKLGKTITVAEDFPAF 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 149 VFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERYRPAPLLRKLVL 228
Cdd:PRK07530  189 IVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLELADFIGLDTCLSIMQVLHDGLADSKYRPCPLLVKYVE 268

                         170
                  ....*....|....*
gi 2044745871 229 AGRLGRRSGQGFYSY 243
Cdd:PRK07530  269 AGWLGRKTGRGFYDY 283
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 83-231 1.19e-43

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 154.23  E-value: 1.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  83 AATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIVEDEAGLVFPRILALIVNEAA 162
Cdd:PRK08268  352 TTTAAAREGLDAARVVLIDLLLDYAAAKRRTLMAAPATSPAARDAAHALFQQDGKAVSVIRDSPGFVAQRTVAMIVNEAA 431

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2044745871 163 FALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERYRPAPLLRKLVLAGR 231
Cdd:PRK08268  432 DIAQQGIASPADIDLAMRLGLNYPLGPLAWGDRLGAARILRVLENLQALYGDPRYRPSPWLRRRAALGL 500
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 152-243 1.82e-35

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 121.94  E-value: 1.82e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 152 RILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERYRPAPLLRKLVLAGR 231
Cdd:pfam00725   6 RLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGYHILEVLAEEFGDRAYRPPPLLEKLVEAGR 85

                          90
                  ....*....|..
gi 2044745871 232 LGRRSGQGFYSY 243
Cdd:pfam00725  86 LGRKTGKGFYKY 97
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 48-243 4.68e-34

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 123.94  E-value: 4.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  48 MEVTNDDAAEKQANIVRMDRLLG-PAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVR 126
Cdd:PRK07819   89 IEAVVEDEAVKTEIFAELDKVVTdPDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPTLVTSEATVA 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 127 GLEELFR-TLGKEVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVL 205
Cdd:PRK07819  169 RAEEFASdVLGKQVVRAQDRSGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAHPMGPLRLSDLVGLDTVKAIA 248

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2044745871 206 RGLHRDLGEERYRPAPLLRKLVLAGRLGRRSGQGFYSY 243
Cdd:PRK07819  249 DSMYEEFKEPLYAPPPLLLRMVEAGLLGKKSGRGFYTY 286
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 58-244 4.27e-26

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 103.70  E-value: 4.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:PRK06130   94 KRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKTSPQTVATTMALLRSIGK 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 E-VEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYP---HGPLEWADRIGLDDVLAVLRGLHRDLg 213
Cdd:PRK06130  174 RpVLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRlalTGPLEQRDMNGLDVHLAVASYLYQDL- 252

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2044745871 214 EERYRPAPLLRKLVLAGRLGRRSGQGFYSYE 244
Cdd:PRK06130  253 ENRTTPSPLLEEKVEAGELGAKSGQGFYAWP 283
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 58-249 8.64e-26

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 105.31  E-value: 8.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:PRK08268  101 KQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGLATDPAVADALYALARAWGK 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 EVEIVEDEAGLvfprilalIVN--------EAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLH 209
Cdd:PRK08268  181 TPVRAKDTPGF--------IVNraarpyytEALRVLEEGVADPATIDAILREAAGFRMGPFELMDLIGLDVNHAVMESVY 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2044745871 210 RDL-GEERYRPAPLLRKLVLAGRLGRRSGQGFYSYEIGGER 249
Cdd:PRK08268  253 RQFyQEPRFRPSLIQQELVAAGRLGRKSGQGFYRYADGAKQ 293
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
78-247 1.58e-25

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 104.98  E-value: 1.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  78 TSlALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIVEDEAGLVFPRILALI 157
Cdd:PRK11154  425 TS-SLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEVIPHAKTSAETIATTVALAKKQGKTPIVVRDGAGFYVNRILAPY 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 158 VNEAAFALMEGtASAADIDTAMkLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGeERYRPAPLLRKLVLAGRLGRRSG 237
Cdd:PRK11154  504 INEAARLLLEG-EPIEHIDAAL-VKFGFPVGPITLLDEVGIDVGTKIIPILEAALG-ERFSAPAAFDKLLNDDRKGRKNG 580

                         170
                  ....*....|
gi 2044745871 238 QGFYSYEIGG 247
Cdd:PRK11154  581 RGFYLYGQKG 590
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 58-243 4.38e-24

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 98.21  E-value: 4.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGK 137
Cdd:PRK08269   94 KREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPAVVDRLAALLERIGK 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 138 EVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPH---GPLEWADRIGLDDVLAVLRGLHRDLGE 214
Cdd:PRK08269  174 VPVVCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRFavlGLLEFIDWGGCDILYYASRYLAGEIGP 253

                         170       180
                  ....*....|....*....|....*....
gi 2044745871 215 ERYRPAPLLRKLVLAGRLGRRSGQGFYSY 243
Cdd:PRK08269  254 DRFAPPAIVVRNMEEGRDGLRTGAGFYDY 282
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 48-243 7.81e-21

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 89.16  E-value: 7.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  48 MEVTNDDAAEKQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRG 127
Cdd:PRK06035   90 VEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAALTSEETFNT 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 128 LEELFRTLGKEVEIVEDEAGLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRG 207
Cdd:PRK06035  170 TVELSKKIGKIPIEVADVPGFFTTRFIEGWLLEAIRSFEIGIATIKDIDEMCKLAFGFPMGPFELMDIIGIDTVYHIAEY 249

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2044745871 208 LHRDLGEERYRPAPLLRKLVLAGRLGRR-----SGQGFYSY 243
Cdd:PRK06035  250 LYEETGDPQFIPPNSLKQMVLNGYVGDKkvkygSKGGWFDY 290
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 48-253 8.94e-21

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 91.05  E-value: 8.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  48 MEVTNDDAAEKQANIVRMDRLLGPAVPITATSLALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRG 127
Cdd:TIGR02441 419 IEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKDTLAS 498

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 128 LEELFRTLGKEVEIVEDEAGLVFPRILALIVNEAAFALMEGTaSAADIDtAMKLGTGYPHGPLEWADRIGLDDVLAVLRG 207
Cdd:TIGR02441 499 AVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGV-DPKKLD-KLTTKFGFPVGAATLADEVGVDVAEHVAED 576

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2044745871 208 LHRDLGeERYR--PAPLLRKLVLAGRLGRRSGQGFYSYEIG--GERDGNT 253
Cdd:TIGR02441 577 LGKAFG-ERFGggSAELLSELVKAGFLGRKSGKGIFIYQEGkkGSKKVNS 625
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
71-243 4.26e-13

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 67.27  E-value: 4.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  71 PAVPITAT-SLALAATEIASWSARPERICGFgTFA-PIEDRGLIELAPALQTSKEAVRGLEELFRTLGK-EVEIVEDEAG 147
Cdd:PRK08293  111 PEKTIFATnSSTLLPSQFAEATGRPEKFLAL-HFAnEIWKNNTAEIMGHPGTDPEVFDTVVAFAKAIGMvPIVLKKEQPG 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 148 LVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLDDVLAVLRGLHRDLGEERYRP-APLLRKL 226
Cdd:PRK08293  190 YILNSLLVPFLSAALALWAKGVADPETIDKTWMIATGAPMGPFGILDIVGLDTAYNITSNWAEATDDENAKKaAALLKEY 269

                         170
                  ....*....|....*..
gi 2044745871 227 VLAGRLGRRSGQGFYSY 243
Cdd:PRK08293  270 IDKGKLGVATGEGFYNY 286
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 7-221 1.59e-12

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 65.83  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871   7 LLAGASPfrdglHALLERSGYrVVSLAEAEESggslpVRYGMEVTNDDAAEKQANIVRMDRLLGPAVPITATSLALAATE 86
Cdd:PRK06129   57 LLDGEAP-----DAVLARIRV-TDSLADAVAD-----ADYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  87 IASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIVEDE-AGLVFPRILALIVNEAAFAL 165
Cdd:PRK06129  126 FTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLARAEALYRAAGQSPVRLRREiDGFVLNRLQGALLREAFRLV 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2044745871 166 MEGTASAADIDTAMKLGTGYP---HGPLEWAD---RIGLDDVLAVLRGLHRDLGEERYRPAP 221
Cdd:PRK06129  206 ADGVASVDDIDAVIRDGLGLRwsfMGPFETIDlnaPGGVADYAQRYGPMYRRMAAERGQPVP 267
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
85-245 6.39e-08

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 52.94  E-value: 6.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  85 TEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIVEDEAGLVFPRILALIVneAAFA 164
Cdd:PRK11730  434 SLLAKALKRPENFCGMHFFNPVHRMPLVEVIRGEKTSDETIATVVAYASKMGKTPIVVNDCPGFFVNRVLFPYF--AGFS 511

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 165 -LMEGTASAADIDTAMKLGTGYPHGPLEWADRIGLD------DVLAVlrGLHRDLGEErYRPAplLRKLVLAGRLGRRSG 237
Cdd:PRK11730  512 qLLRDGADFRQIDKVMEKQFGWPMGPAYLLDVVGIDtahhaqAVMAE--GFPDRMKKD-YRDA--IDVLFEAKRFGQKNG 586


                  ....*...
gi 2044745871 238 QGFYSYEI 245
Cdd:PRK11730  587 KGFYRYEE 594
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 58-144 3.54e-07

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 49.07  E-value: 3.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  58 KQANIVRMDRLLGP-AVPITATSlALAATEIASWSARPERICGFGTFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLG 136
Cdd:pfam02737  93 KRKLFAELDAIAPPdAILATNTS-SLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVATTVELAKKIG 171


                  ....*...
gi 2044745871 137 KEVEIVED 144
Cdd:pfam02737 172 KTPVVVKD 179
PRK07066 PRK07066
L-carnitine dehydrogenase;
64-184 3.25e-06

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 47.52  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871  64 RMDRLLGPAVPITATSLALAATEIASWSARPERiCGFG-TFAPIEDRGLIELAPALQTSKEAVRGLEELFRTLGKEVEIV 142
Cdd:PRK07066  104 RISRAAKPDAIIASSTSGLLPTDFYARATHPER-CVVGhPFNPVYLLPLVEVLGGERTAPEAVDAAMGIYRALGMRPLHV 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2044745871 143 EDEA-GLVFPRILALIVNEAAFALMEGTASAADIDTAMKLGTG 184
Cdd:PRK07066  183 RKEVpGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAG 225
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
158-242 4.88e-06

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 47.16  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044745871 158 VNEAAFALMEG-TASAADIDTAMKLGTGYPH---GPLEWADRIGLDDVLAvLRGLHRDLGeERYRPAPLLRKLVlagrlg 233
Cdd:PRK11730  636 INEVVRCLEEGiVASPAEADMALVYGLGFPPfrgGAFRYLDTLGVANYVA-LADKYAHLG-PLYQVPEGLREMA------ 707


                  ....*....
gi 2044745871 234 rRSGQGFYS 242
Cdd:PRK11730  708 -ANGESYYP 715
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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