|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
1-874 |
0e+00 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 1834.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 1 MSFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQERR 80
Cdd:PRK09532 1 MSFVGLHIHSDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAIELLKVCRNKGIKPIIGNEMYVINGDIEKQKRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 81 PKYHQVVLAKNTKGYKNLVKLTTISHLQGVQGKGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARKVA 160
Cdd:PRK09532 81 RKYHQVVLAKNTQGYKNLVKLTTISHLQGVQGKGIFARPCINKELLEQYHEGLIVTSACLGGEIPQAILSGRPDAARKVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 161 KWYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMRYSG 240
Cdd:PRK09532 161 KWYKKLFGDDFYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLITEDKRLRYSG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TEYLKSAEEMQMLFRDHLPDDVITEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLERLNRKSR 320
Cdd:PRK09532 241 TEYLKSAEEMRLLFRDHLPDDVIAEAIANTLEVADKIEPYNILGEPRIPNYPVPSGHTPDTYVEEVAWQGLLERLNCKSR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 321 NEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLNP 400
Cdd:PRK09532 321 SEVEPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIPVGPGRGSAAGSLVAYCLKITNIDPVHHGLLFERFLNP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 401 ERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVVRGKPTKLK 480
Cdd:PRK09532 401 ERKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADKMAKLIPVSRGKPTKLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 481 VMISNETPEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNNDGSVITQYFMEDLESMG 560
Cdd:PRK09532 481 VMISDETPEPEFKEKYDNDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQKNNDGAVITQYFMEDLESLG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 561 LLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEITGQERKAQKILAKGEHSTLPKDVQKSYELLEAGELEGIFQLESSG 640
Cdd:PRK09532 561 LLKMDFLGLRNLTTIQKTADLIKENRGVEIDLDQLPLDERKALKILAKGEAKKLPKDVQKTHKLLERGDLEGIFQLESSG 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 641 MRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMAGY 720
Cdd:PRK09532 641 MKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPIDYEHQLLEPILNETYGVLVYQEQIMKMAQDLAGY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 721 TLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEYCLSYDTEVLTVEYGLMPIGKIVEKNI 800
Cdd:PRK09532 721 SLGEADLLRRAMGKKKISEMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEYCLSYDTEVLTVEYGLLPIGKIVEENI 800
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2046693488 801 ECTVYSVDSNGNVYTQPVAQWHNRGQQEVFEYCLDDGSIIRATKDHKFMTTDGEMLPIDEIFERGLDLIQVKGL 874
Cdd:PRK09532 801 ECTVYSVDPNGFVYTQPIAQWHHRGEQEVFEYCLEDGSIIRATKDHKFMTTDGEMLPIDEIFERGLELKQIKLP 874
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
2-774 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1128.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 2 SFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQErrp 81
Cdd:COG0587 4 SFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDAG--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 82 kYHQVVLAKNTKGYKNLVKLTTISHLQGvQGKGifsRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARKVAK 161
Cdd:COG0587 81 -YHLVLLAKNREGYRNLCRLLSRAYLEG-FYKG---KPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 162 WYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMR-YSG 240
Cdd:COG0587 156 RLKDIFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRfANA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TEYLKSAEEMQMLFRDHlPddvitEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLERLNrksr 320
Cdd:COG0587 236 ERYLKSPEEMAELFADL-P-----EALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYP---- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 321 NEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLNP 400
Cdd:COG0587 306 EGIPEEYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNP 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 401 ERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPvvRGKPTKLK 480
Cdd:COG0587 386 ERVSMPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIP--NDPGITLE 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 481 VMISNetpEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNND-GSVITQYFMEDLESM 559
Cdd:COG0587 464 KALEE---EPELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMgGRPVTQFDKDDVEAL 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 560 GLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEItgqerkaqkilakgehstlPKDVQKSYELLEAGELEGIFQLESS 639
Cdd:COG0587 541 GLLKFDFLGLRTLTVIRDALDLIKENRGIDIDLADI-------------------PLDDPKTYELLQRGDTIGVFQLESR 601
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 640 GMRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMAG 719
Cdd:COG0587 602 GMRSLLKRLKPDCFEDLVALVALYRPGPMQGGMVPPYIRRKHGREPVEYPHPELEPILKETYGVIVYQEQVMQIAQVLAG 681
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*
gi 2046693488 720 YTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:COG0587 682 FSLGEADLLRRAMGKKKKEEMAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGY 736
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
3-777 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1114.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 3 FVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDI----EKQE 78
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGSRfdkkRISK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 79 RRPKYHQVVLAKNTKGYKNLVKLTTISHLqgvqgKGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARK 158
Cdd:TIGR00594 81 GKEAYHLILLAKNNTGYRNLMKLSSLAYL-----EGFYYKPRIDKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 159 VAKWYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMR- 237
Cdd:TIGR00594 156 AALKYQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKf 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 238 YSGTEYLKSAEEMQMLFRDHlpddviTEAIATTEEVANKVEPYHI-MGEPQIPTPPIPSGHTP-DTYAEEVAWQGLLERL 315
Cdd:TIGR00594 236 YSDEFYLKSPEEMAELFADI------PEALANTVEIAERCNLVDVkLGPPRLPSYQIPPDFTSqEDYLRHLADEGLRERL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 316 NRKSRNEVD-PVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLF 394
Cdd:TIGR00594 310 AAGPPGYKRrAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLF 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 395 ERFLNPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVVRG 474
Cdd:TIGR00594 390 ERFLNPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPG 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 475 KPTKLKVMisnetPEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNND-GSVITQYFM 553
Cdd:TIGR00594 470 KTLKEALE-----ASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEgGAISTQYDM 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 554 EDLESMGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDpdeitgqerkaqkilakgeHSTLPKDVQKSYELLEAGELEGI 633
Cdd:TIGR00594 545 DDLEAVGLLKMDFLGLKTLTLIQDATELIRKRRGIDLD-------------------IASIPLDDKKTFSLLQEGDTTGV 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 634 FQLESSGMRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKI 713
Cdd:TIGR00594 606 FQLESRGMQDLLKRLKPDGFEDIIAVNALYRPGPMESGMIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQEQVMQI 685
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2046693488 714 AQDMAGYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEYCLS 777
Cdd:TIGR00594 686 AQRLAGFSLGEADLLRRAMGKKKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFN 749
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
2-289 |
1.43e-132 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 397.58 E-value: 1.43e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 2 SFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQERRP 81
Cdd:cd12113 1 DFVHLHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCEVYVAPGSRFDKKDKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 82 K----YHQVVLAKNTKGYKNLVKLTTISHLQgvqgkGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAAR 157
Cdd:cd12113 81 GdkryYHLVLLAKNEEGYRNLMKLVSLAYLE-----GFYYKPRIDKELLAKYSEGLIALSACLAGEIPQLLLNGDEEEAR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 158 KVAKWYKDIFG-DDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRM 236
Cdd:cd12113 156 EAALEYRDIFGkDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATNDVHYLNKEDAEAHDVLLCIQTGKTLDDPNRM 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2046693488 237 RYSGTE-YLKSAEEMQMLFRDHLpddvitEAIATTEEVANKVEPYHIMGEPQIP 289
Cdd:cd12113 236 RFDTDEfYLKSPEEMRELFPDVP------EALENTLEIAERCNVELDFGKLHLP 283
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
302-568 |
6.92e-127 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 381.85 E-value: 6.92e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 302 YAEEVAWQGLLERLnrksRNEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMR 381
Cdd:pfam07733 2 YLRKLVEEGLKERY----GEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSLVAYLLG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 382 ITNIDPVHHGLLFERFLNPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGE 461
Cdd:pfam07733 78 ITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 462 ADKMAKLIPVVRGkptklkvMISNET-PEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQ 540
Cdd:pfam07733 158 IDRLAKLIPFELG-------ILEKALeEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLY 230
|
250 260
....*....|....*....|....*....
gi 2046693488 541 -RNNDGSVITQYFMEDLESMGLLKMDFLG 568
Cdd:pfam07733 231 kADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
6-71 |
1.31e-23 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 94.64 E-value: 1.31e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2046693488 6 LHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIIN 71
Cdd:smart00481 2 LHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIVD 67
|
|
| CehA_McbA_metalo |
NF038032 |
CehA/McbA family metallohydrolase domain; This domain, a branch of the PHP superfamily, is ... |
6-53 |
1.80e-04 |
|
CehA/McbA family metallohydrolase domain; This domain, a branch of the PHP superfamily, is found in several partially characterized metallohydrolases, including McbA and CehA. Both were studied as hydrolases of carbaryl, a xenobiotic compound that does not contain a phosphate group, suggesting that presuming members of this family to be phosphoesterases (like many PHP domain-containing proteins) may be incorrect.
Pssm-ID: 468321 [Multi-domain] Cd Length: 315 Bit Score: 44.62 E-value: 1.80e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKI 53
Cdd:NF038032 7 LHIHTNHS--DGPTTPEELARAALAEGLDVIALTDHNTISGRAYFAEL 52
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
1-874 |
0e+00 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 1834.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 1 MSFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQERR 80
Cdd:PRK09532 1 MSFVGLHIHSDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAIELLKVCRNKGIKPIIGNEMYVINGDIEKQKRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 81 PKYHQVVLAKNTKGYKNLVKLTTISHLQGVQGKGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARKVA 160
Cdd:PRK09532 81 RKYHQVVLAKNTQGYKNLVKLTTISHLQGVQGKGIFARPCINKELLEQYHEGLIVTSACLGGEIPQAILSGRPDAARKVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 161 KWYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMRYSG 240
Cdd:PRK09532 161 KWYKKLFGDDFYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLITEDKRLRYSG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TEYLKSAEEMQMLFRDHLPDDVITEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLERLNRKSR 320
Cdd:PRK09532 241 TEYLKSAEEMRLLFRDHLPDDVIAEAIANTLEVADKIEPYNILGEPRIPNYPVPSGHTPDTYVEEVAWQGLLERLNCKSR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 321 NEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLNP 400
Cdd:PRK09532 321 SEVEPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIPVGPGRGSAAGSLVAYCLKITNIDPVHHGLLFERFLNP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 401 ERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVVRGKPTKLK 480
Cdd:PRK09532 401 ERKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADKMAKLIPVSRGKPTKLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 481 VMISNETPEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNNDGSVITQYFMEDLESMG 560
Cdd:PRK09532 481 VMISDETPEPEFKEKYDNDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQKNNDGAVITQYFMEDLESLG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 561 LLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEITGQERKAQKILAKGEHSTLPKDVQKSYELLEAGELEGIFQLESSG 640
Cdd:PRK09532 561 LLKMDFLGLRNLTTIQKTADLIKENRGVEIDLDQLPLDERKALKILAKGEAKKLPKDVQKTHKLLERGDLEGIFQLESSG 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 641 MRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMAGY 720
Cdd:PRK09532 641 MKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPIDYEHQLLEPILNETYGVLVYQEQIMKMAQDLAGY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 721 TLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEYCLSYDTEVLTVEYGLMPIGKIVEKNI 800
Cdd:PRK09532 721 SLGEADLLRRAMGKKKISEMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEYCLSYDTEVLTVEYGLLPIGKIVEENI 800
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2046693488 801 ECTVYSVDSNGNVYTQPVAQWHNRGQQEVFEYCLDDGSIIRATKDHKFMTTDGEMLPIDEIFERGLDLIQVKGL 874
Cdd:PRK09532 801 ECTVYSVDPNGFVYTQPIAQWHHRGEQEVFEYCLEDGSIIRATKDHKFMTTDGEMLPIDEIFERGLELKQIKLP 874
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
1-775 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 1555.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 1 MSFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIE--KQE 78
Cdd:PRK07374 1 MAFVPLHNHSDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAIELLKLCKGKGIKPIIGNEMYVINGSIDdpQPK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 79 RRPKYHQVVLAKNTKGYKNLVKLTTISHLQGVQGKGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARK 158
Cdd:PRK07374 81 KEKRYHLVVLAKNATGYKNLVKLTTISHLNGMRGRGIFSRPCIDKELLKQYSEGLIVSTACLGGEIPQAILRGRPDVARD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 159 VAKWYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMRY 238
Cdd:PRK07374 161 VAAWYKEVFGDDFYLEIQDHGSIEDRIVNVELVRIAKELGIKLIATNDAHYLSKNDVEAHDALLCVLTGKLISDEKRLRY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 239 SGTEYLKSAEEMQMLFRDHLPDDVITEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLERLNRK 318
Cdd:PRK07374 241 TGTEYIKSEEEMLRLFRDHLDPEVIQEAIANTVEVAEKVEEYDILGTYRMPRFPIPEGHTAVSYLTEVTEQGLLKRLKLN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 319 SRNEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFL 398
Cdd:PRK07374 321 SLDEIDENYKERLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIPVGPGRGSAAGSLVAYALGITNIDPVKNGLLFERFL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 399 NPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVVRGKPTK 478
Cdd:PRK07374 401 NPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQIITFNRMTSKAVLKDVARVLDIPYGEADRLAKLIPVVRGKPAK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 479 LKVMISNETPEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNNDGSVITQYFMEDLES 558
Cdd:PRK07374 481 LKAMIGKESPSPEFREKYEKDPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDELVPLQRNNDGQVITQYFMEDIES 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 559 MGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEitgqerkaqkilakgehstLPKDVQKSYELLEAGELEGIFQLES 638
Cdd:PRK07374 561 LGLLKMDFLGLKNLTMIEKTLELVEQSTGERIDPDN-------------------LPLDDEKTFELLARGDLEGIFQLES 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 639 SGMRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMA 718
Cdd:PRK07374 622 SGMRQVVRDLKPSSLEDISSILALYRPGPLDAGLIPKFINRKHGREAIDFAHPLLEPILTETYGIMVYQEQIMKIAQDLA 701
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 2046693488 719 GYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEYC 775
Cdd:PRK07374 702 GYSLGQADLLRRAMGKKKVSEMQKHRGIFVEGASKRGVDEKVADELFDQMVLFAEYC 758
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
2-774 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1128.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 2 SFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQErrp 81
Cdd:COG0587 4 SFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDAG--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 82 kYHQVVLAKNTKGYKNLVKLTTISHLQGvQGKGifsRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARKVAK 161
Cdd:COG0587 81 -YHLVLLAKNREGYRNLCRLLSRAYLEG-FYKG---KPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 162 WYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMR-YSG 240
Cdd:COG0587 156 RLKDIFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRfANA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TEYLKSAEEMQMLFRDHlPddvitEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLERLNrksr 320
Cdd:COG0587 236 ERYLKSPEEMAELFADL-P-----EALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYP---- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 321 NEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLNP 400
Cdd:COG0587 306 EGIPEEYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNP 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 401 ERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPvvRGKPTKLK 480
Cdd:COG0587 386 ERVSMPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIP--NDPGITLE 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 481 VMISNetpEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNND-GSVITQYFMEDLESM 559
Cdd:COG0587 464 KALEE---EPELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMgGRPVTQFDKDDVEAL 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 560 GLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEItgqerkaqkilakgehstlPKDVQKSYELLEAGELEGIFQLESS 639
Cdd:COG0587 541 GLLKFDFLGLRTLTVIRDALDLIKENRGIDIDLADI-------------------PLDDPKTYELLQRGDTIGVFQLESR 601
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 640 GMRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMAG 719
Cdd:COG0587 602 GMRSLLKRLKPDCFEDLVALVALYRPGPMQGGMVPPYIRRKHGREPVEYPHPELEPILKETYGVIVYQEQVMQIAQVLAG 681
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*
gi 2046693488 720 YTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:COG0587 682 FSLGEADLLRRAMGKKKKEEMAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGY 736
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
3-777 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1114.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 3 FVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDI----EKQE 78
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGSRfdkkRISK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 79 RRPKYHQVVLAKNTKGYKNLVKLTTISHLqgvqgKGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARK 158
Cdd:TIGR00594 81 GKEAYHLILLAKNNTGYRNLMKLSSLAYL-----EGFYYKPRIDKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 159 VAKWYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMR- 237
Cdd:TIGR00594 156 AALKYQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKf 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 238 YSGTEYLKSAEEMQMLFRDHlpddviTEAIATTEEVANKVEPYHI-MGEPQIPTPPIPSGHTP-DTYAEEVAWQGLLERL 315
Cdd:TIGR00594 236 YSDEFYLKSPEEMAELFADI------PEALANTVEIAERCNLVDVkLGPPRLPSYQIPPDFTSqEDYLRHLADEGLRERL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 316 NRKSRNEVD-PVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLF 394
Cdd:TIGR00594 310 AAGPPGYKRrAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLF 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 395 ERFLNPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVVRG 474
Cdd:TIGR00594 390 ERFLNPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPG 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 475 KPTKLKVMisnetPEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNND-GSVITQYFM 553
Cdd:TIGR00594 470 KTLKEALE-----ASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEgGAISTQYDM 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 554 EDLESMGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDpdeitgqerkaqkilakgeHSTLPKDVQKSYELLEAGELEGI 633
Cdd:TIGR00594 545 DDLEAVGLLKMDFLGLKTLTLIQDATELIRKRRGIDLD-------------------IASIPLDDKKTFSLLQEGDTTGV 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 634 FQLESSGMRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKI 713
Cdd:TIGR00594 606 FQLESRGMQDLLKRLKPDGFEDIIAVNALYRPGPMESGMIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQEQVMQI 685
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2046693488 714 AQDMAGYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEYCLS 777
Cdd:TIGR00594 686 AQRLAGFSLGEADLLRRAMGKKKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFN 749
|
|
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
2-774 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 1090.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 2 SFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQERRP 81
Cdd:PRK05673 1 RFVHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPEKKDDVSGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 82 KY-HQVVLAKNTKGYKNLVKLTTISHLQGVQGKgifsRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARKVA 160
Cdd:PRK05673 81 AYtHLTLLAKNETGYRNLFKLSSRAYLEGQYGY----KPRIDREWLAEHSEGLIALSGCPSGEVGTALLAGQYDEAEEAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 161 KWYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMRYSG 240
Cdd:PRK05673 157 AEYQEIFGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDPDRFRFYS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TE-YLKSAEEMQMLFRDhLPddvitEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLERLNRKS 319
Cdd:PRK05673 237 PEqYLKSAEEMRELFAD-LP-----EALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEEDYLRKEAKEGLEERLAFLF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 320 RNEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLN 399
Cdd:PRK05673 311 PDEERPEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLN 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 400 PERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVvrgkptKL 479
Cdd:PRK05673 391 PERVSMPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPYGFVDRITKLIPP------DP 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 480 KVMIS---NEtpEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPL-QRNNDGSVITQYFMED 555
Cdd:PRK05673 465 GITLAkayEE--EPELRELYESDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPLyRDPDSGMPVTQFDMKD 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 556 LESMGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDpdeitgqerkaqkilakgeHSTLPKDVQKSYELLEAGELEGIFQ 635
Cdd:PRK05673 543 VEAAGLVKFDFLGLRTLTIIDDALKLIKKRRGIDVD-------------------LEAIPLDDPKTYELLQRGETLGVFQ 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 636 LESSGMRQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQ 715
Cdd:PRK05673 604 LESRGMRDLLKRLKPDCFEDIIALVALYRPGPMESGMIPNFIDRKHGREEIEYPHPELEPILKETYGIIVYQEQVMQIAQ 683
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 2046693488 716 DMAGYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:PRK05673 684 VLAGYSLGGADLLRRAMGKKKPEEMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGY 742
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
1-774 |
0e+00 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 984.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 1 MSFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDieKQERR 80
Cdd:PRK06826 3 MSFVHLHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKQGIKPIIGCEVYVAPRS--RFDKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 81 PK-----YHQVVLAKNTKGYKNLVKLTTISHLQGvqgkgIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDA 155
Cdd:PRK06826 81 PDidnetYHLVLLAKNETGYKNLMKIVSKAFTEG-----FYYKPRVDHELLKEHSEGLIALSACLAGEVPRYILKGNYEK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 156 ARKVAKWYKDIFG-DDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDN 234
Cdd:PRK06826 156 AKEAALFYKDIFGkENFYLELQDHGIPEQRKVNEELIKLSKELGIPLVATNDVHYIRKEDAKAHDVLLCIQTGKTVDDEN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 235 RMRYSGTE-YLKSAEEMQMLFrDHLPddvitEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLE 313
Cdd:PRK06826 236 RMRFPSDEfYLKSPEEMYELF-SYVP-----EALENTVKIAERCNVEFEFGKSKLPKFPLPEGYDPYEYLRELCYEGLKK 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 314 RLNrksrnEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLL 393
Cdd:PRK06826 310 RYP-----NPSEELIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVGPGRGSAAGSLVAYTLGITKIDPIKYNLL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 394 FERFLNPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVVR 473
Cdd:PRK06826 385 FERFLNPERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGRALNYPYAEVDRIAKMIPTEL 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 474 GKpTKLKVMISNetpePEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRnNDGSVITQYFM 553
Cdd:PRK06826 465 GI-TIDKALELN----PELKEAYENDERVRELIDTARALEGLPRHASTHAAGVVISSEPLVEYVPLQK-NDGSIVTQFTM 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 554 EDLESMGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEItgqerkaqkilakgehstlPKDVQKSYELLEAGELEGI 633
Cdd:PRK06826 539 TTLEELGLLKMDFLGLRTLTVIRDAVDLIKKNRGIEIDLDKI-------------------DYDDKKVYKMIGEGKTVGV 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 634 FQLESSGMRQIVRDLKPSNIEDISSILALYRPGPLDAglIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKI 713
Cdd:PRK06826 600 FQLESAGMRSFMKELKPDSLEDIIAGISLYRPGPMDS--IPRYIKNKNNPEKIEYLHPKLEPILKVTYGCIVYQEQVMQI 677
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2046693488 714 AQDMAGYTLGQADLLRRAMGKKKVSEMQKQREKFV--------DGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:PRK06826 678 VRDLAGYSMGRSDLVRRAMSKKKHDVMEEERKNFIygivdeggPGCIRNGIDEETANKIFDSMMDFASY 746
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
1-774 |
0e+00 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 697.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 1 MSFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQerr 80
Cdd:PRK06920 1 MKFVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACKKHGIHPIIGLTASIFSEEEEKS--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 81 pkYHQVVLAKNTKGYKNLVKLTTIshlqgVQGKgifSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARKVA 160
Cdd:PRK06920 78 --YPLVLLAENEIGYQNLLKISSS-----IMTK---SKEGIPKKWLAHYAKGLIAISPGKDGEIEQLLLEDKESQAEEVA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 161 KWYKDIFGDdFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMRYSG 240
Cdd:PRK06920 148 RAYQNMFGN-FYMSLQHHAIQDELLLQEKLPEFSNRVNIPVVATNDVRYINQSDALVHECLLSVESGTKMTDPDRPRLKT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TE-YLKSAEEMQMLFRDHlpddviTEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLlerlnRKS 319
Cdd:PRK06920 227 DQyYLKSSDEMEALFSHV------PEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETADMYLRRVCEEGL-----QKR 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 320 RNEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLN 399
Cdd:PRK06920 296 YGTPKEVHINRLNHELNVISRMGFSDYFLIVWDFMKYAHENHILTGPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLN 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 400 PERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPvvrGKP-TK 478
Cdd:PRK06920 376 PERVTLPDIDIDFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKLIP---SKLgIT 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 479 LKvmiSNETPEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNNDGSVITQYFMEDLES 558
Cdd:PRK06920 453 LK---DAYEESQSLREFIQGNLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAIQEGHNDVYVTQYPADALEE 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 559 MGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEITGQErkaqkilakgehstlpkdvQKSYELLEAGELEGIFQLES 638
Cdd:PRK06920 530 LGLLKMDFLGLRNLTLLENIIKFIEQKTGKEIDIRNLPLQD-------------------EKTFQLLGRGDTTGVFQLES 590
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 639 SGMRQIVRDLKPSNIEDISSILALYRPGPLDAglIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMA 718
Cdd:PRK06920 591 SGMRNVLRGLKPNEFEDIVAVNSLYRPGPMEQ--IPTFIESKHGKRKIEYLHPDLKPILERTYGVIVYQEQIMQIASKLA 668
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*.
gi 2046693488 719 GYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:PRK06920 669 GFSLGEADLLRRAVSKKNRDILDQERKHFVQGCLQNGYDETSAEKIYDLIVRFANY 724
|
|
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
3-774 |
5.15e-169 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 518.26 E-value: 5.15e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 3 FVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEkqerrPK 82
Cdd:PRK05672 5 YAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAAEAAKELGLRLVIGAELSLGPDPDP-----GG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 83 YHQVVLAKNTKGYKNLVKLTTISHLQGVQGKGIFSRPcinkDLLKQYHEGLIVTSACLGGEIPQAIL-SGRPDAARKVAK 161
Cdd:PRK05672 80 PHLLVLARDREGYGRLSRLITRARLRAGKGEYRLDLD----DLAEPAGGHWAILTGCRKGFVILALPyGGDAAALAALAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 162 WYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAE-DNRMRYSG 240
Cdd:PRK05672 156 LLDAFFADRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEaGGWLAPNG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TEYLKSAEEMQMLFRDHLpddvitEAIATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEVAWQGLLERLnrksR 320
Cdd:PRK05672 236 ERHLRSGAEMARLFPDYP------EALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRY----G 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 321 NEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIpVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLNP 400
Cdd:PRK05672 306 PGIPPKARAQIEHELALIAELGYEGYFLTVHDIVRFARSQGI-LCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSP 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 401 ERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIPVVRGKPTKLK 480
Cdd:PRK05672 385 ERDEPPDIDVDFEHDRREEVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVSRWSGSADDLQ 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 481 VmISNETPEPEfkerydnNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQ--RNNDGSVItQYFMEDLES 558
Cdd:PRK05672 465 R-LRQAGLDPE-------SPIPRRVVELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVEnaAMEGRSVI-QWDKDDCAA 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 559 MGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDpdeitgqerkaqkiLAkgehsTLPKDVQKSYELLEAGELEGIFQLES 638
Cdd:PRK05672 536 VGLVKVDVLALGMLSALHRAFDLIAEHRGRRLT--------------LA-----SIPLDDPAVYDMLCRADSVGVFQVES 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 639 SG-MRQIVRdLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDM 717
Cdd:PRK05672 597 RAqMAMLPR-LRPRTFYDLVVEVAIVRPGPIQGGMVHPYLRRRNGQEPVTYPHPELEKVLERTLGVPLFQEQVMQIAIDA 675
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 2046693488 718 AGYTLGQADLLRRAMG-KKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:PRK05672 676 AGFTPGEADQLRRAMAaWRRKGRLERLRERLYDGMLARGYTGEFADRIFEQIKGFGEY 733
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
3-774 |
1.40e-159 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 493.40 E-value: 1.40e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 3 FVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMyiingDIEKQERrpK 82
Cdd:PRK07279 2 FAQLDTKTVYSFMDSLIDLEKYVERAKELGYQTIGIMDKDNLYGAYHFIEGAQKNGLQPILGLEL-----NIFVEEQ--E 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 83 YHQVVLAKNTKGYKNLVKLTTishlQGVQGKGIFSrpcinkdLLKQYHEGLIVTsaclggeIPqailsgrpdaarkVAKW 162
Cdd:PRK07279 75 VTLRLIAKNTQGYKNLLKIST----AKMSGKKQFS-------DLSQYLEGIAVI-------VP-------------YFDW 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 163 YKDI-FGDDFYLEIQDHGSQEDriVNVEIVKIAReleIKFVATNDshfiscfdVEAHDALLCIQTGKLIAEDNRMrySGT 241
Cdd:PRK07279 124 SETLeLPFDYYIGVDQETPGSD--FKRPILPLRT---VRYFESAD--------RETLQMLHAIRDNLSLREVPLV--SSD 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 242 EYLKSAEEMQMLFRDHLPddvitEAIATTEEVANKVEpYHIMGEPQIP--TPPIPSGHtpdtYAEEVAWQGLLERLNRKS 319
Cdd:PRK07279 189 QELISCQSLETLFQERFP-----QALDNLEKLVSGIS-YDFDTDLKLPrfNRDRPAVE----ELRELAELGLKEKGLWSS 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 320 rnevdpVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFLN 399
Cdd:PRK07279 259 ------PYQERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYMGMGRGSAAGSLVAYALDITGIDPVKHNLLFERFLN 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 400 PERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIpVVRGKPTKL 479
Cdd:PRK07279 333 KERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGAKQAIRDVFKRFGVPEYELSNLTKKI-SFRDSLASV 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 480 kvmisnetpepefkerYDNNPHVRHWL----------DMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLqRNNDGSVIT 549
Cdd:PRK07279 412 ----------------YEKNISFRQIInskleyqkafEIAKRIEGNPRQTSIHAAGVVMSDDDLTNHIPL-KYGDDMMIT 474
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 550 QYFMEDLESMGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDPDEITGQERKaqkilakgehsTLpkdvqksyELLEAGE 629
Cdd:PRK07279 475 QYDAHAVEANGLLKMDFLGLRNLTFVQKMQEKVAKDYGIHIDIEAIDLEDKE-----------TL--------ALFAAGD 535
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 630 LEGIFQLESSGMRQIVRDLKPSNIEDISSILALYRPGPLDagLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQ 709
Cdd:PRK07279 536 TKGIFQFEQPGAINLLKRIKPVCFEDIVATTSLNRPGASD--YTDNFVKRRHGQEKVDLIDPVIAPILEPTYGIMLYQEQ 613
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2046693488 710 IMKIAQDMAGYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:PRK07279 614 VMQIAQVFAGFSLGKADLLRRAMSKKNASEMQKMEEDFLQGALELGHSEEKARELFDRMEKFAGY 678
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
1-774 |
4.26e-146 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 456.46 E-value: 4.26e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 1 MSFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINgdiekqerr 80
Cdd:PRK07135 1 MKLINLHTNTEYSFLSSTIKLDSLIKYAKENNLKTLVLTDHNNMFGVPKFYKLCKKNNIKPIIGLDLEVEN--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 81 pkYHQVVLAKNTKGYKNLVKLTtishLQGVQGKGIFSRPCINKDLLkqyheglIVTSACLGgeipqailsgrpdaarkva 160
Cdd:PRK07135 72 --FRFILLAKNYSGYKLLNELS----SKKSKNKEIELNDLDSDNII-------IIDHPKNG------------------- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 161 kwykdifgddFYLEIQDHGSQEDRIVNVEIVKIARELeikFVATNdshfiSCFDVEAHDALLCIQTgklIAEDNRMRYSG 240
Cdd:PRK07135 120 ----------FYAKNKEQLELKNYYINSNDPKIENAV---YVQER-----KLLFAEDNEYLKILNK---IGNNKEENSNF 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 241 TEYlksaeEMQMLFRDhLPDDVIteaiATTEEVANKVEPYHIMGEPQIPTPPIPSGHTPDTYAEEvawqgLLERLNRKSR 320
Cdd:PRK07135 179 KFF-----DFEKWFED-IDEKIL----KRTNYLVENINIEFPKKEFNLPDFDNNLGLESDLFLKK-----ILKESVINKK 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 321 NEV--DPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFERFL 398
Cdd:PRK07135 244 AELkyYPNVKERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIGPGRGSASGSLVSYLLNITSVNPLKYDLLFERFL 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 399 NPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIP-------V 471
Cdd:PRK07135 324 NPDRITMPDIDIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPESDVNAISKLIPnnqsleeA 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 472 VRGKPTKLKVMISNEtpEPEFKERYDNnphvrhwldmAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNNDGSVITQY 551
Cdd:PRK07135 404 YDKNKSFFRELISKG--DPIYKKLYKI----------AKKLEGLPRQSGTHAAGIIISNKPITNYVPTFESKDNYNQVQY 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 552 FMEDLESMGLLKMDFLGLRNLTLIQKTIDLIEETngYRIDPDEITGQerkaqkilakgehstLPKDVQKSYELLEAGELE 631
Cdd:PRK07135 472 SMEFLEDFGLLKIDLLGLKNLTIIKNIEEKINKE--LLFDHLINFND---------------LPIIDKKTNNLLSNGKTE 534
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 632 GIFQLESSGMRQIVRDLKPSNIEDISSILALYRPGPLDagLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIM 711
Cdd:PRK07135 535 GIFQLESPGMKSTIKKVGIDSFEDIVAIISLYRPGPIQ--YIPIYAKNKKNPKNIEKIHPEYDEIVAPTYGIIIYQEQIM 612
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2046693488 712 KIAQDMAGYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:PRK07135 613 QIAQKVAGFSFAQADLLRRAISKKDETKLDKIKDKFIEGGIKNGYSKKVLEKIYSLIEKFADY 675
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
3-774 |
7.42e-144 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 450.45 E-value: 7.42e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 3 FVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEmyiingdIEKQErrPK 82
Cdd:PRK05898 2 FINLNTHSHYSLLSSTLSIDDIIKFALDNNQPYVCLTDLNNLYGCIEFYDKAKAHNLIPIIGLE-------IEYQS--TN 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 83 YHQVVLAKNTKGYKNLVKlttishlqgvqgkgIFSRPCINKDL-LKQYHEGLIVTsaCLGGEI----PQAILSGRPDAAR 157
Cdd:PRK05898 73 ATLVLYAKNYNGYLNLIK--------------ISSFIMTNKEFeIQDYLDDLFIV--CKKGTFvfksPNFYQTHNQNAPN 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 158 KVAkwykdiFGDDFYLEiqdhgsQEDRIVNVEIVKIARELEIkfvatndSHFISCFDVEAHdallciqtgkliaednrmr 237
Cdd:PRK05898 137 AIA------FNSVFYAN------KNDKIVFNAMLAIKNDLKI-------DELKNCQDFDNN------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 238 ysgteYLKSAEEMQMLFRDhlpddvitEAIATTEEVANKVEpYHIMGEP-QIPTPPIPSGHTPDTYAEEVAWQGLLERLN 316
Cdd:PRK05898 179 -----HFLNDNEAQSLFSP--------IQLDNLNKVLNELK-VEIHDLPiNIIKYDKQNSIISSEILKQLCISGLNKRLN 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 317 RKSRNeVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMRITNIDPVHHGLLFER 396
Cdd:PRK05898 245 ANDGQ-VKKIYVKRLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIGPGRGSAAGSLIAYLLHITDIDPIKYNLIFER 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 397 FLNPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGEADKMAKLIpvvrgkp 476
Cdd:PRK05898 324 FLNPTRKSMPDIDTDIMDERRDEVVEYLFEKYGNDHVAHIITFQRIKAKMAIRDVGRILGIDLKVIDKICKNI------- 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 477 tklkvmisnetpEPEFKERYDNNPHVRHWL-----------DMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQRNNDG 545
Cdd:PRK05898 397 ------------KPDYEEDLDLAIKKNTILkemyvlhkelfDLAKKIINAPRQIGTHAAGVVLSNSLLTNIIPIQLGIND 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 546 SVITQYFMEDLESMGLLKMDFLGLRNLTLIQKTIDLIEETNGYRIDpdeitgqerkaqkiLAKgehstLPKDVQKSYELL 625
Cdd:PRK05898 465 RPLSQYSMEYLERFGLIKMDLLGLKNLTIIDNVLKLIKENQNKKID--------------LFN-----INLNDKNVFEDL 525
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 626 EAGELEGIFQLESSGMRQIVRDLKPSNIEDISSILALYRPGPLDAglIPKFINRKHGREAIDYQNPILEPVLNETYGIMV 705
Cdd:PRK05898 526 AKGRTNGIFQLESPGMKKVLKKVKPQNIEDISIVSALFRPGPQQN--IKTFVERRFKREEFSYWNEATKKILEPTHGIIV 603
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2046693488 706 YQEQIMKIAQDMAGYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVADELFEQMLKFAEY 774
Cdd:PRK05898 604 YQEQVINLVKTIANFDIATADNFRRAISKKDEKILIQLKKDFIEGALKNNYKQPLVNQIFEYIFSFADY 672
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
2-289 |
1.43e-132 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 397.58 E-value: 1.43e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 2 SFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQERRP 81
Cdd:cd12113 1 DFVHLHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCEVYVAPGSRFDKKDKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 82 K----YHQVVLAKNTKGYKNLVKLTTISHLQgvqgkGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAAR 157
Cdd:cd12113 81 GdkryYHLVLLAKNEEGYRNLMKLVSLAYLE-----GFYYKPRIDKELLAKYSEGLIALSACLAGEIPQLLLNGDEEEAR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 158 KVAKWYKDIFG-DDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRM 236
Cdd:cd12113 156 EAALEYRDIFGkDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATNDVHYLNKEDAEAHDVLLCIQTGKTLDDPNRM 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2046693488 237 RYSGTE-YLKSAEEMQMLFRDHLpddvitEAIATTEEVANKVEPYHIMGEPQIP 289
Cdd:cd12113 236 RFDTDEfYLKSPEEMRELFPDVP------EALENTLEIAERCNVELDFGKLHLP 283
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
302-568 |
6.92e-127 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 381.85 E-value: 6.92e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 302 YAEEVAWQGLLERLnrksRNEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNNIPVGPGRGSAAGSLVAYAMR 381
Cdd:pfam07733 2 YLRKLVEEGLKERY----GEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSLVAYLLG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 382 ITNIDPVHHGLLFERFLNPERKSMPDIDTDFCIEKRDKVIEYVTEKYGKDRVAQIITFNRLTSKAVLKDVARVLNIPYGE 461
Cdd:pfam07733 78 ITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 462 ADKMAKLIPVVRGkptklkvMISNET-PEPEFKERYDNNPHVRHWLDMAMRIEGTNKTFGVHAAGVVISADPLDEIVPLQ 540
Cdd:pfam07733 158 IDRLAKLIPFELG-------ILEKALeEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLY 230
|
250 260
....*....|....*....|....*....
gi 2046693488 541 -RNNDGSVITQYFMEDLESMGLLKMDFLG 568
Cdd:pfam07733 231 kADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
2-289 |
3.00e-86 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 276.28 E-value: 3.00e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 2 SFVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDiekqeRRP 81
Cdd:cd07433 1 SFVHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPD-----DAD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 82 KYHQVVL-AKNTKGYKNLVKLTTISHLQGvQGKGifsRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDAARKVA 160
Cdd:cd07433 76 EPFRLTLlAQNEQGYKNLTELISRAYLEG-QRNG---GPHIKLEWLAEYSEGLIALSGGRDGDIGQLLLEGNPDLAEALL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 161 KWYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHFISCFDVEAHDALLCIQTGKLIAEDNRMR-YS 239
Cdd:cd07433 152 QFLKKIFPDRFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRrYS 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2046693488 240 GTEYLKSAEEMQMLFRDhLPddvitEAIATTEEVANK--VEPYhiMGEPQIP 289
Cdd:cd07433 232 PQQYFKSAEEMAELFAD-LP-----EAIENTVEIAKRcnVRIE--LGKPFLP 275
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
571-755 |
1.26e-75 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 243.59 E-value: 1.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 571 NLTLIQKTIDLIEETNGYRIDPDEItgqerkaqkilakgehstlPKDVQKSYELLEAGELEGIFQLESSGMRQIVRDLKP 650
Cdd:pfam17657 1 TLTIIRDALDLIKENRGIGIDLATI-------------------PLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKP 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 651 SNIEDISSILALYRPGPLDAGLIPKFINRKHGREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMAGYTLGQADLLRR 730
Cdd:pfam17657 62 DTFEDLVALSALYRPGPMQGGNVDDYIKRKHGKEKIEYPHPDLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRR 141
|
170 180
....*....|....*....|....*
gi 2046693488 731 AMGKKKVSEMQKQREKFVDGAAKNG 755
Cdd:pfam17657 142 AMGKKKPEEMEKLREKFIEGAKENG 166
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
6-178 |
6.91e-60 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 201.23 E-value: 6.91e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 6 LHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINGDIEKQE--RRPKY 83
Cdd:pfam02811 2 LHVHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKAGIKPIIGCEVYVAPGSREETEklLAKYF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 84 HQVVLAKNTKGYKNLVKLTTISHLQGvqgkgifSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILS-GRPDAARKVAKW 162
Cdd:pfam02811 82 DLVLLAVHEVGYKNLIKLSSRAYLEG-------FKPRIDKELLEEYFEGLIALSGCVLGHLDLILLApGDYEEAEELAEE 154
|
170
....*....|....*..
gi 2046693488 163 YKDIFGDD-FYLEIQDH 178
Cdd:pfam02811 155 YLEIFGEDgFYLEINTH 171
|
|
| PHP_PolIIIA_POLC |
cd07435 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
4-279 |
1.19e-42 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; DNA polymerase III alphas (PolIIIAs) that contain a PHP domain have been classified into four basic groups based on phylogenetic and domain structural analyses: polC, dnaE1, dnaE2, and dnaE3. The PolC group is distinct from the other three and is clustered together. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in different location compare to dnaE1, 2, and 3. The PHP domain has four conserved sequence motifs and and contains an invariant histidine that is involved in metal ion coordination.The PHP domain of PolC is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. PHP domains found in dnaEs of thermophilic origin exhibit 3'-5' exonuclease activity. In contrast, PolC PHP lacks detectable nuclease activity.
Pssm-ID: 213990 [Multi-domain] Cd Length: 268 Bit Score: 156.48 E-value: 1.19e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 4 VPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIINgdiekqerrpKY 83
Cdd:cd07435 2 VELHAHTKMSAMDGVTSVKELVKRAAEWGHKAIAITDHGVVQAFPEAYEAAKKNGIKVIYGVEAYLVD----------PY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 84 HQVVLAKNTKGYKNLVKLTTISHLqgvqgKGIFSRPCINKDLLKQYHEGLIVTSACLGGEIPQAILSGRPDA-ARKVAKW 162
Cdd:cd07435 72 HITILVKNQTGLKNLYKLVSLSHT-----KYFYRVPRIPKSELEKYREGLLIGSACENGELFEAALNKKSDEeLEEIASF 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 163 YkDifgddfYLEIQDHGSQEDRI-------------VNVEIVKIARELEIKFVATNDSHFIscfdvEAHDALL--CIQTG 227
Cdd:cd07435 147 Y-D------YIEIQPLDNYQFLIekglikseeelkeINKRIIKLGKKLNKPVVATGDVHYL-----DPEDKIYreILLAG 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2046693488 228 KLIAEDNRMRYSGtEYLKSAEEMQMLFrDHLPDDVITEAIAT-TEEVANKVEP 279
Cdd:cd07435 215 QGGGDGRADEQPD-LYFRTTDEMLDEF-SYLGEEKAYEVVVTnTNKIADMIED 265
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
4-223 |
2.87e-39 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 143.50 E-value: 2.87e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 4 VPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIingdiekQERRPKY 83
Cdd:cd07431 1 AHLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTV-------EGDGEPY 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 84 HQVVLAKNTKGYKNLVKLTTISHLQGVQGKGIFsrpCINKDLLKQYHEGLIVTSACLggeipqailsgrpdaarkvakwy 163
Cdd:cd07431 74 PLLLLAKNNEGYQNLLRLSTAAMLGEEKDGVPY---LDLEELAEAASGLLVVLLGPL----------------------- 127
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 164 kdifgddfyleiqdhgsqedrivnveIVKIARELEIKFVATNDSHFISCFDVEAHDALLC 223
Cdd:cd07431 128 --------------------------LLLLAAEQGLPLVATNDVHYLNPEDAFAADVLTA 161
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
3-274 |
3.39e-26 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 108.70 E-value: 3.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 3 FVPLHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIING-DIekqerrp 81
Cdd:cd07434 1 YAELHCLSNFSFLRGASHPEELVARAAELGYRALAITDECSLAGVVRAHAAAKELGLKLIVGSELVLADGtRL------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 82 kyhqVVLAKNTKGYKNLVKLTTISHLQGVQGKGIFSRpcinKDLLkQYHEGLIvtsACLGGEIPQAIlsgrPDAARKVAK 161
Cdd:cd07434 74 ----VLLARDRAGYGRLCRLITLGRRRAEKGEYRLTL----ADLL-AHAEGLL---LILLPPDRLPA----AAALLAQLR 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 162 WYKDIFGDDFYLEIQDHGSQEDRIVNVEIVKIARELEIKFVATNDSHfiscFDVEA----HDALLCIQTGKLIAEDNRMR 237
Cdd:cd07434 138 WLARAFPGRLWLALELHLGGDDARRLARLAALAAALGLPLVATGDVL----MHSPSrrplQDVLTAIRLGTTVAEAGRRL 213
|
250 260 270
....*....|....*....|....*....|....*...
gi 2046693488 238 YSGTE-YLKSAEEMQMLFRDHLpddvitEAIATTEEVA 274
Cdd:cd07434 214 AANAErHLRSPAELARLFLYPP------EALAETLEIA 245
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
65-595 |
2.05e-25 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 113.78 E-value: 2.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 65 NEMYIINGDIEKQerRPkYHQVVLAKNTKGYKNLVKLTTISHLqgvqgKGIFSRPCINKDLLKQYHEGLIVTSACLGGEI 144
Cdd:PRK00448 596 NKKLGSEDAYKKA--RP-KHATILVKNQVGLKNLFKLVSLSNT-----KYFYRVPRIPRSLLDKYREGLLIGSACEEGEV 667
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 145 PQAILSGRPDAARKVAKWYkDifgddfYLEIQ-----------DHGSQEDRI--VNVEIVKIARELEIKFVATNDSHFIS 211
Cdd:PRK00448 668 FDAVLQKGDEELEEIAKFY-D------YIEIQppanyqhlierELVKDEEELkeIIKNLIELGKKLNKPVVATGDVHYLD 740
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 212 CFDVEAHDALLCIQTGKliAEDNRMRYSgTEYLKSAEEM--QMLFrdhLPDDVITEA-IATTEEVANKVEPYHimgepqi 288
Cdd:PRK00448 741 PEDKIYRKILVASQGGG--NPLNRHPLP-ELHFRTTDEMldEFAF---LGEELAKEIvVENTNKIADLIEEIE------- 807
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 289 ptpPIPSG-HTP--DTYAEEVAwqgllERLNRKSR----NEVDPVYKERLEYELKMLQQMGFSTYFLVVWDYIKFARDNN 361
Cdd:PRK00448 808 ---PIKDKlYTPkiEGAEEEIR-----ELTYKKAHeiygEPLPEIVEKRIEKELNSIIGNGFAVIYLISQKLVKKSLEDG 879
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 362 IPVGPgRGSAAGSLVAYAMRITNIDPV--H---------------------------------------HGLLFERFLNP 400
Cdd:PRK00448 880 YLVGS-RGSVGSSFVATMIGITEVNPLppHyvcpnckysefftdgsvgsgfdlpdkdcpkcgtklkkdgHDIPFETFLGF 958
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 401 ERKSMPDIDTDFCIEKRDKVIEYVTEKYGKD---RVAQIITFnrltskavlkdvarvlnipygeADKMAklIPVVRGkpt 477
Cdd:PRK00448 959 KGDKVPDIDLNFSGEYQPVAHNYTKVLFGEDhvfRAGTIGTV----------------------AEKTA--YGYVKK--- 1011
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 478 klkvmisnetpepefkerY--DNNPHVRH-WLD-MAMRIEGTNKTFGVHAAGVVISADPLD--EIVPLQR---NNDGSVI 548
Cdd:PRK00448 1012 ------------------YeeDTGKFYRNaEIDrLAQGCTGVKRTTGQHPGGIIVVPKYMDiyDFTPIQYpadDVNSEWK 1073
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 2046693488 549 TQYFmeDLESMG--LLKMDFLGLRNLTLIQKTIDLieeTNgyrIDPDEI 595
Cdd:PRK00448 1074 TTHF--DFHSIHdnLLKLDILGHDDPTMIRMLQDL---TG---IDPKTI 1114
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
6-71 |
1.31e-23 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 94.64 E-value: 1.31e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2046693488 6 LHIHSDYSLLDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIIN 71
Cdd:smart00481 2 LHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIVD 67
|
|
| PHP_HisPPase |
cd07432 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase ... |
6-67 |
1.55e-13 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. HisPPase can be classified into two types: the bifunctional HisPPase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213987 [Multi-domain] Cd Length: 129 Bit Score: 68.03 E-value: 1.55e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2046693488 6 LHIHSDYSllDGASQLP-ELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEM 67
Cdd:cd07432 3 LHIHSVFS--PDSDMTPeEIVERAIELGLDGIAITDHNTIDGAEEALKEAYKDGLLVIPGVEV 63
|
|
| Hop |
COG1372 |
Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, ... |
682-853 |
2.96e-12 |
|
Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, transposons];
Pssm-ID: 440983 [Multi-domain] Cd Length: 866 Bit Score: 70.69 E-value: 2.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 682 GREAIDYQNPILEPVLNETYGIMVYQEQIMKIAQDMAGYTLGQADLLRRAMGKKKVSEMQKQREKFVDGAAKNGVKKQVA 761
Cdd:COG1372 4 LKETEIVLVATLVTDALRLKLLELKEEGIELLKLELDLEELGEVLAEALVRAIDGASLILLAAGGGVLLVALTGLGREAA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 762 DELFEQMLKFAEY-CLSYDTEVLTVEYGLMPIGKIVEKNIECTVYSVDSNGN-VYTQPVAQWHNRGQQEVFEYCLDDGSI 839
Cdd:COG1372 84 AGLALAGGDTGTGvCLTGDTLVLTADGRLVPIGELVGSGEDVEVLSLDLDTGkLVWAPVTKVFKTGVKPVYRIRTRSGRE 163
|
170
....*....|....
gi 2046693488 840 IRATKDHKFMTTDG 853
Cdd:COG1372 164 IRATPDHPFLTLSG 177
|
|
| HintN |
smart00306 |
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ... |
774-853 |
4.31e-12 |
|
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.
Pssm-ID: 197642 [Multi-domain] Cd Length: 100 Bit Score: 63.06 E-value: 4.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 774 YCLSYDTEVLTVEYGLMPIGKIVEkniECTVYSVDSNGNVYT--QPVAQWHNRGQQEVFEYCLDDGSIIRATKDHKFMTT 851
Cdd:smart00306 1 GCFPGDTLVLTEDGGIKKIEELEE---GDKVLALDEGTLKYSpvKVFLVREPKGEKKFYRIKTENGREITLTPDHLLLVR 77
|
..
gi 2046693488 852 DG 853
Cdd:smart00306 78 DG 79
|
|
| YciV |
COG0613 |
5'-3' exoribonuclease TrpH/YciV (RNase AM), contains PHP domain [Nucleotide transport and ... |
6-67 |
2.45e-11 |
|
5'-3' exoribonuclease TrpH/YciV (RNase AM), contains PHP domain [Nucleotide transport and metabolism];
Pssm-ID: 440378 [Multi-domain] Cd Length: 188 Bit Score: 63.39 E-value: 2.45e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEM 67
Cdd:COG0613 6 LHVHTTAS--DGSLSPEELVARAKAAGLDVLAITDHDTVAGYEEAAEAAKELGLLVIPGVEI 65
|
|
| intein_Nterm |
TIGR01445 |
intein N-terminal splicing region; This model is based on interated search results, starting ... |
776-850 |
2.91e-11 |
|
intein N-terminal splicing region; This model is based on interated search results, starting with a curated collection of intein N-terminal splicing regions from InBase, the New England Biolabs Intein Database, as presented on its web site. It is designed to recognize inteins but not the related region of the sonic hedgehog protein.
Pssm-ID: 273629 [Multi-domain] Cd Length: 81 Bit Score: 60.02 E-value: 2.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 776 LSYDTEVLTvEYGLM-PIGKIVEKNIEC------TVYSVDSNGNVYTQPVAQWHNRGQQEVFEYCLDDGSIIRATKDHKF 848
Cdd:TIGR01445 1 LTGDTKVLT-EDGETvKIGELVEKEKDEkepikvKVLSLDGGKIVKARPVVVWKRRAEGKLIRIKTENGREIKATPDHPF 79
|
..
gi 2046693488 849 MT 850
Cdd:TIGR01445 80 LT 81
|
|
| PHP |
cd07309 |
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2 ... |
4-72 |
4.00e-10 |
|
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP in polymerases has trinuclear zinc/magnesium dependent proofreading activity. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213985 [Multi-domain] Cd Length: 88 Bit Score: 57.05 E-value: 4.00e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2046693488 4 VPLHIHSDYSLLDGASqLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKPIIGNEMYIING 72
Cdd:cd07309 1 VDLHTHTVFSDGDHAK-LTELVDKAKELGPDALAITDHGNLRGLAEFNTAGK*NHIKAAEAAGIKIIIG 68
|
|
| Hint |
cd00081 |
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ... |
775-856 |
4.36e-10 |
|
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.
Pssm-ID: 238035 [Multi-domain] Cd Length: 136 Bit Score: 58.43 E-value: 4.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 775 CLSYDTEVLTVEYGLMPIGKIVE-KNIEctVYSVDSNGNVYTQPVAQW-HNRGQQEVFEYCLDDGSIIRATKDHKFMTTD 852
Cdd:cd00081 1 CFTGDTLVLLEDGGRKKIEELVEkKGDK--VLALDETGKLVFSKVLKVlRRDYEKKFYKIKTESGREITLTPDHLLFVLE 78
|
....
gi 2046693488 853 GEML 856
Cdd:cd00081 79 DGEL 82
|
|
| PHP_HisPPase_AMP |
cd07438 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) ... |
6-75 |
5.01e-09 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; The PHP domain of this HisPPase family has an unknown function. It has a second domain inserted in the middle that binds adenosine 5-monophosphate (AMP). The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to give histidinol. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to the other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213993 [Multi-domain] Cd Length: 155 Bit Score: 55.86 E-value: 5.01e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKICRSKNIKpiignemyIINGdIE 75
Cdd:cd07438 3 LHTHSTAS--DGTLSPEELVELAKEAGLKVLAITDHDTVAGLEEALAAAKELGIE--------LIPG-VE 61
|
|
| HIS2 |
COG1387 |
Histidinol phosphatase or related hydrolase of the PHP family [Amino acid transport and ... |
6-42 |
5.34e-07 |
|
Histidinol phosphatase or related hydrolase of the PHP family [Amino acid transport and metabolism, General function prediction only]; Histidinol phosphatase or related hydrolase of the PHP family is part of the Pathway/BioSystem: Histidine biosynthesis
Pssm-ID: 440997 [Multi-domain] Cd Length: 232 Bit Score: 51.69 E-value: 5.34e-07
10 20 30
....*....|....*....|....*....|....*..
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDHG 42
Cdd:COG1387 5 LHTHTTYS--DGEGTIEEMVEAAIELGLEYIAITDHS 39
|
|
| PHP_PolX |
cd07436 |
Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; The bacterial/archaeal ... |
6-41 |
6.44e-06 |
|
Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; The bacterial/archaeal X-family DNA polymerases (PolXs) have a PHP domain at their C-terminus. The bacterial/archaeal PolX core domain and PHP domain interact with each other and together are involved in metal dependent 3'-5' exonuclease activity. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PolX is found in all kingdoms, however bacterial PolXs have a completely different domain structure from eukaryotic PolXs. Bacterial PolX has an extended conformation in contrast to the common closed 'right hand' conformation for DNA polymerases. This extended conformation is stabilized by the PHP domain. The PHP domain of PolX is structurally homologous to other members of the PHP family that has a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213991 [Multi-domain] Cd Length: 237 Bit Score: 48.18 E-value: 6.44e-06
10 20 30
....*....|....*....|....*....|....*.
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDH 41
Cdd:cd07436 9 LHVHTTWS--DGRNSIEEMAEAARALGYEYIAITDH 42
|
|
| PRK07945 |
PRK07945 |
PHP domain-containing protein; |
6-41 |
8.70e-05 |
|
PHP domain-containing protein;
Pssm-ID: 236135 [Multi-domain] Cd Length: 335 Bit Score: 45.74 E-value: 8.70e-05
10 20 30
....*....|....*....|....*....|....*.
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDH 41
Cdd:PRK07945 100 LHTHSDWS--DGGSPIEEMARTAAALGHEYCALTDH 133
|
|
| CehA_McbA_metalo |
NF038032 |
CehA/McbA family metallohydrolase domain; This domain, a branch of the PHP superfamily, is ... |
6-53 |
1.80e-04 |
|
CehA/McbA family metallohydrolase domain; This domain, a branch of the PHP superfamily, is found in several partially characterized metallohydrolases, including McbA and CehA. Both were studied as hydrolases of carbaryl, a xenobiotic compound that does not contain a phosphate group, suggesting that presuming members of this family to be phosphoesterases (like many PHP domain-containing proteins) may be incorrect.
Pssm-ID: 468321 [Multi-domain] Cd Length: 315 Bit Score: 44.62 E-value: 1.80e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDHGVMYGAVELIKI 53
Cdd:NF038032 7 LHIHTNHS--DGPTTPEELARAALAEGLDVIALTDHNTISGRAYFAEL 52
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
775-861 |
1.53e-03 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 42.43 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2046693488 775 CLSYDTEVLTVEYGL-MPIGKIV-EKNIEctVYSVD-SNGNVYTQPVAQWHNRGQQEVFEYCLDDGSIIRATKDHKFMTT 851
Cdd:PRK07773 398 CLTGDTLILRADTGAeVPIGELVgERPFA--VWALDeRTLRLVAAPVSNVFPTGRKPVFRLRTRSGREIRATANHPFLTF 475
|
90
....*....|
gi 2046693488 852 DGeMLPIDEI 861
Cdd:PRK07773 476 EG-WKRLDEL 484
|
|
| PRK08609 |
PRK08609 |
DNA polymerase/3'-5' exonuclease PolX; |
6-42 |
8.89e-03 |
|
DNA polymerase/3'-5' exonuclease PolX;
Pssm-ID: 236311 [Multi-domain] Cd Length: 570 Bit Score: 39.55 E-value: 8.89e-03
10 20 30
....*....|....*....|....*....|....*..
gi 2046693488 6 LHIHSDYSllDGASQLPELVDRAIALGIKAIALTDHG 42
Cdd:PRK08609 338 LHMHTTWS--DGAFSIEEMVEACIAKGYEYMAITDHS 372
|
|
| |
