|
Name |
Accession |
Description |
Interval |
E-value |
| TrmN6 |
COG4123 |
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
12-247 |
2.20e-109 |
|
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 315.16 E-value: 2.20e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 12 ERIDDLLTHELGIIQSEEVFSFSMDAVLLARFASIPRRGRILDMCTGNGVVPILLSTRTGAL-IEGIEIQPRLADMARRS 90
Cdd:COG4123 1 ERLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPGArITGVEIQPEAAELARRN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 91 VEMNNLQDQITIHEGDLRELYKEQGYGAYDLITVNPPYMPMNGSDLKLNEHQAIARHEIHCTLEEVIESCAKLLRQGGKM 170
Cdd:COG4123 81 VALNGLEDRITVIHGDLKEFAAELPPGSFDLVVSNPPYFKAGSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2048586036 171 SMVHKPLRLAEIITLMSKYRIEPKVIRFVHPRVNMEANMVLIEGIRDGKPEVRLKPPLIVYDEQGNYGPNFMEIYYG 247
Cdd:COG4123 161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRILPPLVIHDEDGEYTPEVKALLRD 237
|
|
| PRK14968 |
PRK14968 |
putative methyltransferase; Provisional |
28-130 |
2.01e-11 |
|
putative methyltransferase; Provisional
Pssm-ID: 237872 [Multi-domain] Cd Length: 188 Bit Score: 61.07 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 28 EEVFSFSMDAVLLARFASIPRRGRILDMCTGNGVVPILLSTRtGALIEGIEIQPRLADMARRSVEMNNLQDQ-ITIHEGD 106
Cdd:PRK14968 3 DEVYEPAEDSFLLAENAVDKKGDRVLEVGTGSGIVAIVAAKN-GKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSD 81
|
90 100
....*....|....*....|....
gi 2048586036 107 LRELYKEqgyGAYDLITVNPPYMP 130
Cdd:PRK14968 82 LFEPFRG---DKFDVILFNPPYLP 102
|
|
| L3_gln_methyl |
TIGR03533 |
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ... |
51-128 |
9.66e-11 |
|
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]
Pssm-ID: 274633 [Multi-domain] Cd Length: 284 Bit Score: 60.60 E-value: 9.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 51 RILDMCTGNGVVPILLSTR-TGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDL-RELYKEQgygaYDLITVNPPY 128
Cdd:TIGR03533 124 RILDLCTGSGCIAIACAYAfPEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLfAALPGRK----YDLIVSNPPY 199
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
51-170 |
1.69e-09 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 53.97 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 51 RILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRsVEMNNLQDQITIHEGDLRELYKEQGyGAYDLITVNPPYmp 130
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARK-AAAALLADNVEVLKGDAEELPPEAD-ESFDVIISDPPL-- 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2048586036 131 mngsdlklnehqaiarHEIHCTLEEVIESCAKLLRQGGKM 170
Cdd:cd02440 77 ----------------HHLVEDLARFLEEARRLLKPGGVL 100
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
52-168 |
4.40e-09 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 52.57 E-value: 4.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 52 ILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRSVEMNNLqdQITIHEGDLRELykEQGYGAYDLITVNPPYMPM 131
Cdd:pfam13649 1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDL--PFPDGSFDLVVSSGVLHHL 76
|
90 100 110
....*....|....*....|....*....|....*..
gi 2048586036 132 NGSDlklnehqaiarheihctLEEVIESCAKLLRQGG 168
Cdd:pfam13649 77 PDPD-----------------LEAALREIARVLKPGG 96
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TrmN6 |
COG4123 |
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
12-247 |
2.20e-109 |
|
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 315.16 E-value: 2.20e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 12 ERIDDLLTHELGIIQSEEVFSFSMDAVLLARFASIPRRGRILDMCTGNGVVPILLSTRTGAL-IEGIEIQPRLADMARRS 90
Cdd:COG4123 1 ERLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPGArITGVEIQPEAAELARRN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 91 VEMNNLQDQITIHEGDLRELYKEQGYGAYDLITVNPPYMPMNGSDLKLNEHQAIARHEIHCTLEEVIESCAKLLRQGGKM 170
Cdd:COG4123 81 VALNGLEDRITVIHGDLKEFAAELPPGSFDLVVSNPPYFKAGSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2048586036 171 SMVHKPLRLAEIITLMSKYRIEPKVIRFVHPRVNMEANMVLIEGIRDGKPEVRLKPPLIVYDEQGNYGPNFMEIYYG 247
Cdd:COG4123 161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRILPPLVIHDEDGEYTPEVKALLRD 237
|
|
| Trm11 |
COG1041 |
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ... |
31-200 |
2.60e-13 |
|
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440663 [Multi-domain] Cd Length: 172 Bit Score: 66.13 E-value: 2.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 31 FSFSMD---AVLLARFASIPRRGRILDMCTGNGVVPI---LLstrtGALIEGIEIQPRLADMARRSVEMNNLQDqITIHE 104
Cdd:COG1041 6 YPGSLDprlARALVNLAGAKEGDTVLDPFCGTGTILIeagLL----GRRVIGSDIDPKMVEGARENLEHYGYED-ADVIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 105 GDLRELykEQGYGAYDLITVNPPYmpmnGSDLKlnehqaIARHEIHCTLEEVIESCAKLLRQGGKMSMVhKPLRLAEIIT 184
Cdd:COG1041 81 GDARDL--PLADESVDAIVTDPPY----GRSSK------ISGEELLELYEKALEEAARVLKPGGRVVIV-TPRDIDELLE 147
|
170
....*....|....*.
gi 2048586036 185 LmSKYRIEPKVIRFVH 200
Cdd:COG1041 148 E-AGFKVLERHEQRVH 162
|
|
| HemK |
COG2890 |
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ... |
40-130 |
6.50e-13 |
|
Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442135 [Multi-domain] Cd Length: 282 Bit Score: 66.71 E-value: 6.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 40 LARFASiPRRGRILDMCTGNGVVPI-LLSTRTGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDLRElyKEQGYGA 118
Cdd:COG2890 105 LALLPA-GAPPRVLDLGTGSGAIALaLAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFE--PLPGDGR 181
|
90
....*....|..
gi 2048586036 119 YDLITVNPPYMP 130
Cdd:COG2890 182 FDLIVSNPPYIP 193
|
|
| PRK14968 |
PRK14968 |
putative methyltransferase; Provisional |
28-130 |
2.01e-11 |
|
putative methyltransferase; Provisional
Pssm-ID: 237872 [Multi-domain] Cd Length: 188 Bit Score: 61.07 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 28 EEVFSFSMDAVLLARFASIPRRGRILDMCTGNGVVPILLSTRtGALIEGIEIQPRLADMARRSVEMNNLQDQ-ITIHEGD 106
Cdd:PRK14968 3 DEVYEPAEDSFLLAENAVDKKGDRVLEVGTGSGIVAIVAAKN-GKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSD 81
|
90 100
....*....|....*....|....
gi 2048586036 107 LRELYKEqgyGAYDLITVNPPYMP 130
Cdd:PRK14968 82 LFEPFRG---DKFDVILFNPPYLP 102
|
|
| RsmC |
COG2813 |
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
17-178 |
4.97e-11 |
|
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 60.20 E-value: 4.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 17 LLTHELGIIQSEEVFSF-SMD--AVLLARFASIPRRGRILDMCTGNGVVPILLSTRTGAL-IEGIEIQPRLADMARRSVE 92
Cdd:COG2813 15 LAGRDLTFVTLPGVFSRdRLDigTRLLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEArVTLVDVNARAVELARANAA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 93 MNNLQDqITIHEGDLRELYKEqgyGAYDLITVNPPYmpmngsdlklneHQAIARH-EIhctLEEVIESCAKLLRQGGKMS 171
Cdd:COG2813 95 ANGLEN-VEVLWSDGLSGVPD---GSFDLILSNPPF------------HAGRAVDkEV---AHALIADAARHLRPGGELW 155
|
170
....*....|
gi 2048586036 172 MV---HKPLR 178
Cdd:COG2813 156 LVanrHLPYE 165
|
|
| L3_gln_methyl |
TIGR03533 |
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ... |
51-128 |
9.66e-11 |
|
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]
Pssm-ID: 274633 [Multi-domain] Cd Length: 284 Bit Score: 60.60 E-value: 9.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 51 RILDMCTGNGVVPILLSTR-TGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDL-RELYKEQgygaYDLITVNPPY 128
Cdd:TIGR03533 124 RILDLCTGSGCIAIACAYAfPEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLfAALPGRK----YDLIVSNPPY 199
|
|
| hemK_fam |
TIGR00536 |
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ... |
4-168 |
5.29e-10 |
|
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]
Pssm-ID: 273125 [Multi-domain] Cd Length: 284 Bit Score: 58.52 E-value: 5.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 4 KEVLLQSSERIDDLLTHELG------IIQSEEVFSFSM---DAVLLAR----------FASIPRRG---RILDMCTGNGV 61
Cdd:TIGR00536 48 EELTPDEKERIFRLVLRRVKgvpvayLLGSKEFYGLEFfvnEHVLIPRpeteelvekaLASLISQPpilHILDLGTGSGC 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 62 VPI-LLSTRTGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDLRELYKEQgygAYDLITVNPPYMPMNgsdlKLNE 140
Cdd:TIGR00536 128 IALaLAYEFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNLFEPLAGQ---KIDIIVSNPPYIDEE----DLAD 200
|
170 180 190
....*....|....*....|....*....|....*...
gi 2048586036 141 HQAIARHEIHCTL----------EEVIESCAKLLRQGG 168
Cdd:TIGR00536 201 LPNVVRFEPLLALvggddglnilRQIIELAPDYLKPNG 238
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
51-170 |
1.69e-09 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 53.97 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 51 RILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRsVEMNNLQDQITIHEGDLRELYKEQGyGAYDLITVNPPYmp 130
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARK-AAAALLADNVEVLKGDAEELPPEAD-ESFDVIISDPPL-- 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2048586036 131 mngsdlklnehqaiarHEIHCTLEEVIESCAKLLRQGGKM 170
Cdd:cd02440 77 ----------------HHLVEDLARFLEEARRLLKPGGVL 100
|
|
| PRK09328 |
PRK09328 |
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional |
36-168 |
2.82e-09 |
|
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
Pssm-ID: 236467 [Multi-domain] Cd Length: 275 Bit Score: 56.32 E-value: 2.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 36 DAVLLARFAsiPRRGRILDMCTGNGVVPI-LLSTRTGALIEGIEIQPRLADMARRSVEmNNLQDQITIHEGDlreLYKEQ 114
Cdd:PRK09328 98 EWALEALLL--KEPLRVLDLGTGSGAIALaLAKERPDAEVTAVDISPEALAVARRNAK-HGLGARVEFLQGD---WFEPL 171
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2048586036 115 GYGAYDLITVNPPYMPMNGSDLKLNEhqaIARHEIHCTL----------EEVIESCAKLLRQGG 168
Cdd:PRK09328 172 PGGRFDLIVSNPPYIPEADIHLLQPE---VRDHEPHLALfggedgldfyRRIIEQAPRYLKPGG 232
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
52-168 |
4.40e-09 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 52.57 E-value: 4.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 52 ILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRSVEMNNLqdQITIHEGDLRELykEQGYGAYDLITVNPPYMPM 131
Cdd:pfam13649 1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDL--PFPDGSFDLVVSSGVLHHL 76
|
90 100 110
....*....|....*....|....*....|....*..
gi 2048586036 132 NGSDlklnehqaiarheihctLEEVIESCAKLLRQGG 168
Cdd:pfam13649 77 PDPD-----------------LEAALREIARVLKPGG 96
|
|
| MTS |
pfam05175 |
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ... |
37-173 |
1.52e-08 |
|
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.
Pssm-ID: 428349 [Multi-domain] Cd Length: 170 Bit Score: 52.59 E-value: 1.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 37 AVLLARFASiPRRGRILDMCTGNGVVPILLSTRTG-ALIEGIEIQPRLADMARRSVEMNNLqDQITIHEGDLrelYKEQG 115
Cdd:pfam05175 21 RLLLEHLPK-DLSGKVLDLGCGAGVLGAALAKESPdAELTMVDINARALESARENLAANGL-ENGEVVASDV---YSGVE 95
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2048586036 116 YGAYDLITVNPPYmpmngsdlklneHQaiARHEIHCTLEEVIESCAKLLRQGGKMSMV 173
Cdd:pfam05175 96 DGKFDLIISNPPF------------HA--GLATTYNVAQRFIADAKRHLRPGGELWIV 139
|
|
| PRK14967 |
PRK14967 |
putative methyltransferase; Provisional |
36-177 |
2.25e-08 |
|
putative methyltransferase; Provisional
Pssm-ID: 184931 [Multi-domain] Cd Length: 223 Bit Score: 53.13 E-value: 2.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 36 DAVLLARF---ASIPRRGRILDMCTGNGVVPIlLSTRTGAL-IEGIEIQPRLADMARRSVEMNNLqdQITIHEGDLRELY 111
Cdd:PRK14967 21 DTQLLADAlaaEGLGPGRRVLDLCTGSGALAV-AAAAAGAGsVTAVDISRRAVRSARLNALLAGV--DVDVRRGDWARAV 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2048586036 112 KEqgyGAYDLITVNPPYMPMNGSDLklnEHQAIAR-----HEIHCTLEEVIESCAKLLRQGGKMSMVHKPL 177
Cdd:PRK14967 98 EF---RPFDVVVSNPPYVPAPPDAP---PSRGPARawdagPDGRAVLDRLCDAAPALLAPGGSLLLVQSEL 162
|
|
| hemK_rel_arch |
TIGR00537 |
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ... |
30-135 |
6.87e-08 |
|
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 129628 [Multi-domain] Cd Length: 179 Bit Score: 51.01 E-value: 6.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 30 VFSFSMDAVLLARFASIPRRGRILDMCTGNGVVPILLSTRtGALIEGIEIQPRLADMARRSVEMNNLQdqITIHEGDLRE 109
Cdd:TIGR00537 1 VYEPAEDSLLLEANLRELKPDDVLEIGAGTGLVAIRLKGK-GKCILTTDINPFAVKELRENAKLNNVG--LDVVMTDLFK 77
|
90 100
....*....|....*....|....*.
gi 2048586036 110 LYKeqgyGAYDLITVNPPYMPMNGSD 135
Cdd:TIGR00537 78 GVR----GKFDVILFNPPYLPLEDDL 99
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
39-170 |
2.08e-07 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 49.16 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 39 LLARFASIPRRGRILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDLRELYKEqgyGA 118
Cdd:COG2230 42 LILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPAD---GQ 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2048586036 119 YDLIT-------VNPPYMPmngsdlklnehqaiarheihctleEVIESCAKLLRQGGKM 170
Cdd:COG2230 119 FDAIVsigmfehVGPENYP------------------------AYFAKVARLLKPGGRL 153
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
37-168 |
3.42e-07 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 49.53 E-value: 3.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 37 AVLLARFASIPRRGRILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRSVEMNNLqDQITIHEGDLRELYKEQGy 116
Cdd:COG0500 15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELDPLPA- 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2048586036 117 GAYDLITVNppympmngsdlklNEHQAIARHEihctLEEVIESCAKLLRQGG 168
Cdd:COG0500 93 ESFDLVVAF-------------GVLHHLPPEE----REALLRELARALKPGG 127
|
|
| TrmA |
COG2265 |
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ... |
36-127 |
4.91e-07 |
|
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 441866 [Multi-domain] Cd Length: 377 Bit Score: 49.79 E-value: 4.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 36 DAVLlaRFASIPRRGRILDMCTGNGVVPILLSTRTGALIeGIEIQPRLADMARRSVEMNNLqDQITIHEGDL-RELYKEQ 114
Cdd:COG2265 223 AAAL--EWLDLTGGERVLDLYCGVGTFALPLARRAKKVI-GVEIVPEAVEDARENARLNGL-KNVEFVAGDLeEVLPELL 298
|
90
....*....|...
gi 2048586036 115 GYGAYDLITVNPP 127
Cdd:COG2265 299 WGGRPDVVVLDPP 311
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
39-170 |
1.10e-06 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 46.55 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 39 LLARFasIPRRGRILDMCTGNGVVPILLSTRtGALIEGIEIQPRLADMARRSVEMNNlqdqITIHEGDLRELykEQGYGA 118
Cdd:COG2227 17 LLARL--LPAGGRVLDVGCGTGRLALALARR-GADVTGVDISPEALEIARERAAELN----VDFVQGDLEDL--PLEDGS 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2048586036 119 YDLITvnppympMNGSdLklnEHQAiarheihcTLEEVIESCAKLLRQGGKM 170
Cdd:COG2227 88 FDLVI-------CSEV-L---EHLP--------DPAALLRELARLLKPGGLL 120
|
|
| Trm5 |
COG2520 |
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ... |
41-129 |
1.11e-06 |
|
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 442010 [Multi-domain] Cd Length: 333 Bit Score: 48.70 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 41 ARFASIPRRG-RILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDLRELyKEQGYGAY 119
Cdd:COG2520 172 LRIAELVKPGeRVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLNKVEDRVTPILGDAREV-APELEGKA 250
|
90
....*....|
gi 2048586036 120 DLITVNPPYM 129
Cdd:COG2520 251 DRIIMNLPHS 260
|
|
| TrmR |
COG4122 |
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ... |
35-122 |
2.58e-06 |
|
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443298 Cd Length: 173 Bit Score: 46.33 E-value: 2.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 35 MDAV--LLARFASIPRRGRILDMCTGNGVvpillST-------RTGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEG 105
Cdd:COG4122 1 MPEQgrLLYLLARLLGAKRILEIGTGTGY-----STlwlaralPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILG 75
|
90
....*....|....*..
gi 2048586036 106 DLRELYKEQGYGAYDLI 122
Cdd:COG4122 76 DALEVLPRLADGPFDLV 92
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
1-123 |
9.34e-06 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 44.99 E-value: 9.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 1 MKLKEVLLQS----SERIDDLLTHELGIIQSEEVFsfsmdAVLLARFAsIPRRGRILDMCTGNGVVPILLSTRtGALIEG 76
Cdd:COG4976 1 MALDAYVEALfdqyADSYDAALVEDLGYEAPALLA-----EELLARLP-PGPFGRVLDLGCGTGLLGEALRPR-GYRLTG 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2048586036 77 IEIQPRLADMARRSvemnnlQDQITIHEGDLRELykEQGYGAYDLIT 123
Cdd:COG4976 74 VDLSEEMLAKAREK------GVYDRLLVADLADL--AEPDGRFDLIV 112
|
|
| PRK14966 |
PRK14966 |
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ... |
41-181 |
1.73e-05 |
|
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional
Pssm-ID: 184930 [Multi-domain] Cd Length: 423 Bit Score: 45.46 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 41 ARFASIPRRGRILDMCTGNGVVPILLS-TRTGALIEGIEIQPRLADMARRSVEmnNLQDQITIHEGDLRELyKEQGYGAY 119
Cdd:PRK14966 244 AVLARLPENGRVWDLGTGSGAVAVTVAlERPDAFVRASDISPPALETARKNAA--DLGARVEFAHGSWFDT-DMPSEGKW 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2048586036 120 DLITVNPPYMPMNGSDLKlnehQAIARHEIHCTLEEVIE--SCAKLLRQGGkmsmvhkPLRLAE 181
Cdd:PRK14966 321 DIIVSNPPYIENGDKHLL----QGDLRFEPQIALTDFSDglSCIRTLAQGA-------PDRLAE 373
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
40-125 |
1.63e-04 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 40.75 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 40 LARFASIPRRGRILDMCTGNGVVPILLStRTGALIEGIEIQPRLADMARRSVEMNNLqdQITIHEGDLREL-YKEqgyGA 118
Cdd:COG2226 14 LLAALGLRPGARVLDLGCGTGRLALALA-ERGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLpFPD---GS 87
|
....*..
gi 2048586036 119 YDLITVN 125
Cdd:COG2226 88 FDLVISS 94
|
|
| RlmL |
COG0116 |
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ... |
69-128 |
1.78e-04 |
|
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification
Pssm-ID: 439886 [Multi-domain] Cd Length: 369 Bit Score: 42.01 E-value: 1.78e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 69 RTGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDLRELYKEQGYGaydLITVNPPY 128
Cdd:COG0116 248 DPPLPIFGSDIDPRAIEAARENAERAGVADLIEFEQADFRDLEPPAEPG---LIITNPPY 304
|
|
| COG4076 |
COG4076 |
Predicted RNA methylase [General function prediction only]; |
31-110 |
5.33e-04 |
|
Predicted RNA methylase [General function prediction only];
Pssm-ID: 443253 [Multi-domain] Cd Length: 230 Bit Score: 40.02 E-value: 5.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 31 FSFSMDAVLLARF-ASIPRRGR----ILDMCTGNGVVPiLLSTRTGAL-IEGIEIQPRLADMARRSVEMNNLQDQITIHE 104
Cdd:COG4076 13 HPMLNDVERNDAFkAAIERVVKpgdvVLDIGTGSGLLS-MLAARAGAKkVYAVEVNPDIAAVARRIIAANGLSDRITVIN 91
|
....*.
gi 2048586036 105 GDLREL 110
Cdd:COG4076 92 ADATDL 97
|
|
| Cons_hypoth95 |
pfam03602 |
Conserved hypothetical protein 95; |
48-129 |
3.55e-03 |
|
Conserved hypothetical protein 95;
Pssm-ID: 427391 [Multi-domain] Cd Length: 179 Bit Score: 37.22 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048586036 48 RRGRILDMCTGNGVVPILLSTRTGALIEGIEIQPRLADMARRSVEMNNLQDQITIHEGDLRELYKEQGYGAYDLITVNPP 127
Cdd:pfam03602 41 EGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQILKENLQLLGLPGAVLVMDALLALLRLAGKGPVFDIVFLDPP 120
|
..
gi 2048586036 128 YM 129
Cdd:pfam03602 121 YA 122
|
|
| |
