phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   6 LFVDDVAEDVELATLELGRWPaaWVSRRVDNEPQLRAALAEFAPDIVLCDLNLPGFDG-EAARAIvRAQAPASLFVFLTG 84
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGlELLRKL-RELPPDIPVIVLTA 77

                  ....*..
gi 2049861625  85 ATADATE 91
Cdd:cd00156    78 KADEEDA 84

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   6 LFVDDVAEDVELATLELGRWPaaWVSRRVDNEPQLRAALAEFAPDIVLCDLNLPGFDG-EAARAIvRAQAPASLFVFLTG 84
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGlELLRKL-RELPPDIPVIVLTA 77

                  ....*..
gi 2049861625  85 ATADATE 91
Cdd:cd00156    78 KADEEDA 84

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2049861625  34 VDNEPQLRAALAEFAPDIVLCDLNLPGFDG-EAARAIvRAQAPASLFVFLTGATADAT 90
Cdd:pfam00072  28 ADDGKEALELLKEERPDLILLDINMPGMDGlELLKRI-RRRDPTTPVIILTAHGDEDD 84

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   6 LFVDDVAEDVELATLELGRWPaaWVSRRVDNEPQLRAALAEFAPDIVLCDLNLPGFDG-EAARAIvRAQAPASLFVFLTG 84
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGlELLRKL-RELPPDIPVIVLTA 77

                  ....*..
gi 2049861625  85 ATADATE 91
Cdd:cd00156    78 KADEEDA 84

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   4 RLLFVDDVAEDVELATLELGRWpaAWVSRRVDNEPQLRAALAEFAPDIVLCDLNLPGFDG-EAARAIVRAQAPASL-FVF 81
Cdd:COG0784     7 RILVVDDNPDNRELLRRLLERL--GYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGlELLRRIRALPRLPDIpIIA 84

                          90
                  ....*....|.
gi 2049861625  82 LTGATADATEH 92
Cdd:COG0784    85 LTAYADEEDRE 95

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   4 RLLFVDDVAEDVELATLELGRwpAAWVSRRVDNEPQLRAALAEFAPDIVLCDLNLPGFDGEAARAIVRAQAPASLFVFLT 83
Cdd:COG2204     4 RILVVDDDPDIRRLLKELLER--AGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLT 81

                  .
gi 2049861625  84 G 84
Cdd:COG2204    82 G 82

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2049861625  44 LAEFAPDIVLCDLNLPGFDG-EAARAIvRAQAPASLFVFLTG 84
Cdd:cd17536    41 IEEHKPDIVITDIRMPGMDGlELIEKI-RELYPDIKIIILSG 81

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   4 RLLFVDDVAEDVELATLELGRWPAAWVSrrVDNEPQLRAALAEFAPDIVLCDLNLPGFDG-EAARAIVRAQAPASL-FVF 81
Cdd:COG3437     8 TVLIVDDDPENLELLRQLLRTLGYDVVT--AESGEEALELLLEAPPDLILLDVRMPGMDGfELLRLLRADPSTRDIpVIF 85

                          90
                  ....*....|
gi 2049861625  82 LTGATADATE 91
Cdd:COG3437    86 LTALADPEDR 95

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   2 TWRLLFVDDVAEDVELATLELGRwpAAWVSRRVDNEPQLRAALAEFAPDIVLCDLNLPGFDG-EAARAIVRAQAPASL-F 79
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEA--AGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGlELCRRLRADPRTADIpI 78

                  ....*
gi 2049861625  80 VFLTG 84
Cdd:COG3706    79 IFLTA 83

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2049861625  41 RAALAEFA---PDIVLCDLNLPGFDGEAARAIVRAQAPASLFVFLTGA--TADATEHLDETVWD 99
Cdd:cd17555    34 RQGLELFRseqPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSGAgvMSDAVEALRLGAWD 97

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   4 RLLFVDDVAEDVELATLELgRWPAAWVSRRVDNEPQLRAAlAEFAPDIVLCDLNLPGFDGEAARAIVRAQAPASLFVFLT 83
Cdd:cd17615     1 RVLVVDDEPNITELLSMAL-RYEGWDVETAADGAEALAAA-REFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLT 78

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2049861625   4 RLLFVDDVAEDVELATLELGRWpaawVSRRVDNEPQLRAALA---EFAPDIVLCDLNLPGFDG-EAARAIVRAQAPASL 78
Cdd:cd17530     2 RVLVLDDDPFQCMMAATILEDL----GPGNVDEADDGREALVillCNAPDIIICDLKMPDMDGiEFLRHLAESHSNAAV 76

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049861625   1 MTWRLLFVDDvaEDVELATLELG-RWPAAWVSRRVDNEPQLRAALAEFAPDIVLCDLNLPGFDGEAARAIVRAQAPASLf 79
Cdd:COG3707     2 RGLRVLVVDD--EPLRRADLREGlREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPV- 78

                  ....*
gi 2049861625  80 VFLTG 84
Cdd:COG3707    79 ILLTA 83

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2049861625  42 AALAEFAPDIVLCDLNLPGFDG-EAARAIvRAQAPASLFVFLT 83
Cdd:cd17574    35 ELAREEQPDLIILDVMLPGMDGfEVCRRL-REKGSDIPIIMLT 76