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Conserved domains on  [gi|2049896151|ref|WP_215529683|]
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MULTISPECIES: phosphopyruvate hydratase [unclassified Cupriavidus]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-428 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 885.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIM 80
Cdd:COG0148     1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSL 160
Cdd:COG0148    81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 161 DIQEFMIMPVSQTSFREALRCGAEVFHALKKILADKGMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLA 240
Cdd:COG0148   161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 241 LDCAASEFYHeaEDVYALEGEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTN 320
Cdd:COG0148   241 LDVAASEFYK--DGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 321 TKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRI 400
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                         410       420
                  ....*....|....*....|....*...
gi 2049896151 401 AKYNQLIRIEEDLGDIATYPGKSAFYNL 428
Cdd:COG0148   399 AKYNQLLRIEEELGDAARYAGRSAFKRL 426
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-428 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 885.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIM 80
Cdd:COG0148     1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSL 160
Cdd:COG0148    81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 161 DIQEFMIMPVSQTSFREALRCGAEVFHALKKILADKGMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLA 240
Cdd:COG0148   161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 241 LDCAASEFYHeaEDVYALEGEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTN 320
Cdd:COG0148   241 LDVAASEFYK--DGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 321 TKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRI 400
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                         410       420
                  ....*....|....*....|....*...
gi 2049896151 401 AKYNQLIRIEEDLGDIATYPGKSAFYNL 428
Cdd:COG0148   399 AKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
 1-429 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 864.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIM 80
Cdd:PRK00077    1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSL 160
Cdd:PRK00077   81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 161 DIQEFMIMPVSQTSFREALRCGAEVFHALKKILADKGMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLA 240
Cdd:PRK00077  161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 241 LDCAASEFYHeaEDVYALEGEGlkLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTN 320
Cdd:PRK00077  241 LDCAASEFYK--DGKYVLEGEG--LTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTN 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 321 TKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRI 400
Cdd:PRK00077  317 TKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 396

                         410       420
                  ....*....|....*....|....*....
gi 2049896151 401 AKYNQLIRIEEDLGDIATYPGKSAFYNLR 429
Cdd:PRK00077  397 AKYNQLLRIEEELGDAARYAGKKAFKNLK 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-428 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 733.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   4 IVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIMGLD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  84 ASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSLDIQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 164 EFMIMPVSQTSFREALRCGAEVFHALKKILADKGMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLALDC 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 244 AASEFYHEAEDVYALEGEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTNTKI 323
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTEI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 324 LKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRIAKY 403
Cdd:TIGR01060 321 LREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAKY 400

                         410       420
                  ....*....|....*....|....*
gi 2049896151 404 NQLIRIEEDLGDIATYPGKSAFYNL 428
Cdd:TIGR01060 401 NQLLRIEEELGDSARYAGKNSFYRF 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-412 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 716.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   6 DIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIMGLDAS 85
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  86 EQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSLDIQEF 165
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 166 MIMPVSQTSFREALRCGAEVFHALKKILADKG--MSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLALDC 243
Cdd:cd03313   161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 244 AASEFYHEAEDVYALEgEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTNTKI 323
Cdd:cd03313   241 AASEFYDEGKYVYDSD-EGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 324 LKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRIAKY 403
Cdd:cd03313   320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399


                  ....*....
gi 2049896151 404 NQLIRIEED 412
Cdd:cd03313   400 NQLLRIEEE 408
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
142-428 9.89e-159

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 449.62  E-value: 9.89e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 142 MPVPMMNIVNGGAHANNSLDIQEFMIMPVSQTSFREALRCGAEVFHALKKILADKG--MSTAVGDEGGFAPNFSSNEECL 219
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNKEAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 220 NTIVQAVEKAGYKvgEDVLLALDCAASEFYHEAEDVYALEGEGL------KLSSTQFADYLANLCDKFPIVSIEDGMAEG 293
Cdd:pfam00113  84 DLIVEAIEKAGYK--GKIKIAMDVASSEFYNKKDGKYDLDFKGEksdkskKLTSAQLADLYEELVKKYPIVSIEDPFDED 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 294 DWEGWKTLTEKLGKRVQLVGDDLFVTNTKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETE 373
Cdd:pfam00113 162 DWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGETE 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2049896151 374 DSTIADIAVGTNAGQIKTGSLSRSDRIAKYNQLIRIEEDLGDIATYPGKSAFYNL 428
Cdd:pfam00113 242 DTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-428 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 885.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIM 80
Cdd:COG0148     1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSL 160
Cdd:COG0148    81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 161 DIQEFMIMPVSQTSFREALRCGAEVFHALKKILADKGMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLA 240
Cdd:COG0148   161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 241 LDCAASEFYHeaEDVYALEGEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTN 320
Cdd:COG0148   241 LDVAASEFYK--DGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 321 TKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRI 400
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                         410       420
                  ....*....|....*....|....*...
gi 2049896151 401 AKYNQLIRIEEDLGDIATYPGKSAFYNL 428
Cdd:COG0148   399 AKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
 1-429 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 864.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIM 80
Cdd:PRK00077    1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSL 160
Cdd:PRK00077   81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 161 DIQEFMIMPVSQTSFREALRCGAEVFHALKKILADKGMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLA 240
Cdd:PRK00077  161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 241 LDCAASEFYHeaEDVYALEGEGlkLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTN 320
Cdd:PRK00077  241 LDCAASEFYK--DGKYVLEGEG--LTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTN 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 321 TKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRI 400
Cdd:PRK00077  317 TKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 396

                         410       420
                  ....*....|....*....|....*....
gi 2049896151 401 AKYNQLIRIEEDLGDIATYPGKSAFYNLR 429
Cdd:PRK00077  397 AKYNQLLRIEEELGDAARYAGKKAFKNLK 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-428 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 733.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   4 IVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIMGLD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  84 ASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSLDIQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 164 EFMIMPVSQTSFREALRCGAEVFHALKKILADKGMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLALDC 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 244 AASEFYHEAEDVYALEGEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTNTKI 323
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTEI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 324 LKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRIAKY 403
Cdd:TIGR01060 321 LREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAKY 400

                         410       420
                  ....*....|....*....|....*
gi 2049896151 404 NQLIRIEEDLGDIATYPGKSAFYNL 428
Cdd:TIGR01060 401 NQLLRIEEELGDSARYAGKNSFYRF 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-412 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 716.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   6 DIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIMGLDAS 85
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  86 EQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGGAHANNSLDIQEF 165
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 166 MIMPVSQTSFREALRCGAEVFHALKKILADKG--MSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKVGEDVLLALDC 243
Cdd:cd03313   161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 244 AASEFYHEAEDVYALEgEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKLGKRVQLVGDDLFVTNTKI 323
Cdd:cd03313   241 AASEFYDEGKYVYDSD-EGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 324 LKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRIAKY 403
Cdd:cd03313   320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399


                  ....*....
gi 2049896151 404 NQLIRIEED 412
Cdd:cd03313   400 NQLLRIEEE 408
PTZ00081 PTZ00081
enolase; Provisional
 1-423 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 546.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGVMgRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIM 80
Cdd:PTZ00081    1 MSTIKSIKAREILDSRGNPTVEVDLTTEKGVF-RAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVENVNEIIAPALI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIE-LDGTDN-----KGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGG-----SGAMQMPVPMMNI 149
Cdd:PTZ00081   80 GKDVTDQKKLDKLMVEqLDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQlagkpTDKFVLPVPCFNV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 150 VNGGAHANNSLDIQEFMIMPVSQTSFREALRCGAEVFHALKKILADK-GMS-TAVGDEGGFAPNFSSNEECLNTIVQAVE 227
Cdd:PTZ00081  160 INGGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKyGLDaTNVGDEGGFAPNIKDPEEALDLLVEAIK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 228 KAGYKvGEdVLLALDCAASEFYHEAEDVYALE------GEGLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTL 301
Cdd:PTZ00081  240 KAGYE-GK-VKICMDVAASEFYDKEKKVYDLDfknpnnDKSNKLTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAKL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 302 TEKLGKRVQLVGDDLFVTNTKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIA 381
Cdd:PTZ00081  318 TAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADLV 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2049896151 382 VGTNAGQIKTGSLSRSDRIAKYNQLIRIEEDLGDIATYPGKS 423
Cdd:PTZ00081  398 VGLGTGQIKTGAPCRSERLAKYNQLLRIEEELGSNAVYAGEN 439
PLN00191 PLN00191
enolase
 1-423 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 516.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGvMGRAAVPSGASTGSREAIELRDGDKsRYLGKGVLKAVEHINTEISEAIM 80
Cdd:PLN00191   25 MATITKVKARQIIDSRGNPTVEVDLHTSKG-MFRAAVPSGASTGIYEALELRDGDK-DYLGKGVLKAVKNVNEIIAPALI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYF---GGSGAMQMPVPMMNIVNGGAHAN 157
Cdd:PLN00191  103 GMDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIadlAGNKKLVLPVPAFNVINGGSHAG 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 158 NSLDIQEFMIMPVSQTSFREALRCGAEVFHALKKILADK--GMSTAVGDEGGFAPNFSSNEECLNTIVQAVEKAGYKvgE 235
Cdd:PLN00191  183 NKLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKygQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYT--G 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 236 DVLLALDCAASEFYHEaEDVYALEGE------GLKLSSTQFADYLANLCDKFPIVSIEDGMAEGDWEGWKTLTEKlgKRV 309
Cdd:PLN00191  261 KIKIGMDVAASEFYTK-DKKYDLDFKeenndgSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSL--EDV 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 310 QLVGDDLFVTNTKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQI 389
Cdd:PLN00191  338 QIVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQI 417

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2049896151 390 KTGSLSRSDRIAKYNQLIRIEEDLGDIATYPGKS 423
Cdd:PLN00191  418 KTGAPCRSERLAKYNQLLRIEEELGDEAVYAGEN 451
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
142-428 9.89e-159

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 449.62  E-value: 9.89e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 142 MPVPMMNIVNGGAHANNSLDIQEFMIMPVSQTSFREALRCGAEVFHALKKILADKG--MSTAVGDEGGFAPNFSSNEECL 219
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNKEAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 220 NTIVQAVEKAGYKvgEDVLLALDCAASEFYHEAEDVYALEGEGL------KLSSTQFADYLANLCDKFPIVSIEDGMAEG 293
Cdd:pfam00113  84 DLIVEAIEKAGYK--GKIKIAMDVASSEFYNKKDGKYDLDFKGEksdkskKLTSAQLADLYEELVKKYPIVSIEDPFDED 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 294 DWEGWKTLTEKLGKRVQLVGDDLFVTNTKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETE 373
Cdd:pfam00113 162 DWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGETE 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2049896151 374 DSTIADIAVGTNAGQIKTGSLSRSDRIAKYNQLIRIEEDLGDIATYPGKSAFYNL 428
Cdd:pfam00113 242 DTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
Enolase_N pfam03952
Enolase, N-terminal domain;
4-133 8.04e-78

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 237.27  E-value: 8.04e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   4 IVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVEHINTEISEAIMGLD 83
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2049896151  84 ASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRY 133
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRY 130
PRK08350 PRK08350
hypothetical protein; Provisional
 1-415 1.85e-23

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 100.65  E-value: 1.85e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151   1 MSAIVDIIGREVLDSRGNPTVECDVLLESGvMGRAAVPSgastgsreaielrDGDKSRYLGKGvLKAVEHINTEISEAIM 80
Cdd:PRK08350    1 MTVIENIIGRVAVLRGGKYSVEVDVITDSG-FGRFAAPI-------------DENPSLYIAEA-HRAVSEVDEIIGPELI 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  81 GLDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQMPVPMMNIVNGgahannsl 160
Cdd:PRK08350   66 GFDASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTFTTELPVPILEFAED-------- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 161 DIQEFMIMpvsqtsFREALRCgAEVFHALKKILADkgmstavgdeggfapnfsSNEECLNTIVQAVEKAGYKVGEDVLLa 240
Cdd:PRK08350  138 ENFEYYVL------VRDLMEI-TDVVDAVNKILEN------------------SKEVSLEGLSKASEKAGDELGLEVAL- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 241 ldcaasefyheaedvyalegeGLKLSSTQFADYLANLCDKFPIVSIEdgmAEGDWEGWKTLTEKLgKRVQLVGDDLFVTN 320
Cdd:PRK08350  192 ---------------------GIAQKREMETEKVLNLVEDNNIAYIK---PIGDEELFLELIAGT-HGVFIDGEYLFRTR 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 321 TKilkegIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSGETEDSTIADIAVGTNAGQIktgsLSRSDRI 400
Cdd:PRK08350  247 NI-----LDRRYYNALSIKPINLGTLTDLYNLVNDVKSERITPILAEAKYESADEALPHLAVGLRCPAM----LIHKDSV 317

                         410
                  ....*....|....*
gi 2049896151 401 AKYNQLIRIEEDLGD 415
Cdd:PRK08350  318 EKINELNRIAEDLGE 332
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 223-391 5.15e-13

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 68.12  E-value: 5.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 223 VQAVEKAgykVGEDVLLALDCAASEFYHEAedvyalegeglklssTQFADYLAnlcdKFPIVSIEDGMAEGDWEGWKTLT 302
Cdd:cd00308    84 VRAVREA---FGPDARLAVDANGAWTPKEA---------------IRLIRALE----KYGLAWIEEPCAPDDLEGYAALR 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 303 EKLGkrVQLVGDDLFVTNTKILkEGIEKGIGNSILIKINQIGTLTETFAAIEMAKRAGYTAVISHRSG-ETEDSTIADIA 381
Cdd:cd00308   142 RRTG--IPIAADESVTTVDDAL-EALELGAVDILQIKPTRVGGLTESRRAADLAEAFGIRVMVHGTLEsSIGTAAALHLA 218

                         170
                  ....*....|.
gi 2049896151 382 VGT-NAGQIKT 391
Cdd:cd00308   219 AALpNDRAIET 229
PTZ00378 PTZ00378
hypothetical protein; Provisional
 82-413 1.07e-04

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 44.48  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151  82 LDASEQAFLDRTLIELDGTDNKGRLGANAMLAVSMAVAKAAAEEAGLPLYRY----FGGSGAMQ---MPVPMMNIVNGGA 154
Cdd:PTZ00378  122 LGARDQREFDSTLRAALSTSPLANVGSAVQWALSIVASLAAARCRSVPLFQYlralFGSLTSVEtfsMPQLCITFFGPGN 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 155 HANNSLDIQEFMIMPV--SQTSFREALRcgaEVFHALKKILadKGMSTAVGDEGGFA-PNFSSNEECLNTIVQAVEKAGY 231
Cdd:PTZ00378  202 PSTARLALKSVLFSPVmpSGTVLRERMQ---KIFAAFHHFC--QSHNSSVRSDGSLHwDGFANLTDAVKLATEALRAVQL 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 232 KVGEDVLLALDCAAS----------------EFYHEAEDVYALEGEGLKLSSTQFADYLANLCDKFP--IVSIEDGMAEG 293
Cdd:PTZ00378  277 TPGTDVCLGLRMAASttrvpatavadggawkEAKDDCEVLYSLFPGEPDVTGDQLSEYVREQLQAVPdiVVYVEDTHCDE 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049896151 294 DWEGWKTLTEKLGKRVQLVGDDLFV-TNTKILKEGIEKGIGNSILIKINQIGTLTETFAAIEMAKR-AGYTAVISHRSGE 371
Cdd:PTZ00378  357 DTFGLQRLQAALGDSIVLSGVDVYArSEYKKVESGLRGLWTSNIVLNPCAIGTLSDVVEIVRAVGEdEGRAVTVLVQTLA 436

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2049896151 372 TEDSTIADIAVGTNAGQIKTGSLSRSDRIAKYNQLIRIEEDL 413
Cdd:PTZ00378  437 GNAATAAHLAVAMGARFLCSGGLFSAHQCEVVSQLASRQDEL 478
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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