|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
1-474 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 860.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 1 MRRLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSF 80
Cdd:PRK06247 1 MKRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 81 AEGSIQLKNGESFVLDSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVS 160
Cdd:PRK06247 81 ADGKVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 161 LPDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRASVMAKIEKPQAIDRLPEIIEVSDALMVA 240
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 241 RGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPVE 320
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 321 AVSTMNRIGEEVERDPTYRGVLTAQRAEPEPTVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAITP 400
Cdd:PRK06247 321 AVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTP 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2050194471 401 NLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRIASVGPDG 474
Cdd:PRK06247 401 NPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDD 474
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
3-470 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 734.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 3 RLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAE 82
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 83 GSIQLKNGESFVLDSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVSLP 162
Cdd:COG0469 81 GPVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 163 DTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIR---GRASVMAKIEKPQAIDRLPEIIEVSDALMV 239
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEeagGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 240 ARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPV 319
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 320 EAVSTMNRIGEEVERDPTYRGVLTAQRAEPEPTVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAIT 399
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2050194471 400 PNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRIASV 470
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
5-467 |
2.14e-167 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 480.24 E-value: 2.14e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 5 RRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEGS 84
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 85 IQLKNGESFVLDSD--KTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVSLP 162
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 163 DTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIR----GRASVMAKIEKPQAIDRLPEIIEVSDALM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGekgaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 239 VARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 319 VEAVSTMNRIGEEVERDPTYRGVLT-AQRAEPEP-TVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVV 396
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNdRKNSDPKPsTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2050194471 397 AITPNLATGRKLSAVWGVHCVVAED-AKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRI 467
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
4-470 |
1.18e-150 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 437.90 E-value: 1.18e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 4 LRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEG 83
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 84 S-IQLKNGESFVLDSD--KTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAV-TRVVIGGKMSDRKGV 159
Cdd:cd00288 81 KdISLKAGDKFLVTTDpaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTLvCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 160 SLPDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRAS---VMAKIEKPQAIDRLPEIIEVSDA 236
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKdikIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 237 LMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGK 316
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 317 FPVEAVSTMNRIGEEVERDPTYRGVLTAQR-AEPEPT-VGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPP 394
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRrLTPRPTsTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 395 VVAITPNLATGRKLSAVWGVHCVVAEDAK-----DLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTpGTTNMVRIAS 469
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRILT 479
|
.
gi 2050194471 470 V 470
Cdd:cd00288 480 V 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
4-342 |
3.22e-114 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 340.11 E-value: 3.22e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 4 LRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEG 83
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 84 S--IQLKNGESFVLDSD---KTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPE-RAVTRVVIGGKMSDRK 157
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDakyKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 158 GVSLPDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRG---RASVMAKIEKPQAIDRLPEIIEVS 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEagkNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 235 DALMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAA 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|....*...
gi 2050194471 315 GKFPVEAVSTMNRIGEEVERDPTYRGVL 342
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
1-474 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 860.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 1 MRRLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSF 80
Cdd:PRK06247 1 MKRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 81 AEGSIQLKNGESFVLDSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVS 160
Cdd:PRK06247 81 ADGKVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 161 LPDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRASVMAKIEKPQAIDRLPEIIEVSDALMVA 240
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 241 RGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPVE 320
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 321 AVSTMNRIGEEVERDPTYRGVLTAQRAEPEPTVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAITP 400
Cdd:PRK06247 321 AVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTP 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2050194471 401 NLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRIASVGPDG 474
Cdd:PRK06247 401 NPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDD 474
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
3-470 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 734.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 3 RLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAE 82
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 83 GSIQLKNGESFVLDSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVSLP 162
Cdd:COG0469 81 GPVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 163 DTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIR---GRASVMAKIEKPQAIDRLPEIIEVSDALMV 239
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEeagGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 240 ARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPV 319
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 320 EAVSTMNRIGEEVERDPTYRGVLTAQRAEPEPTVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAIT 399
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2050194471 400 PNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRIASV 470
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
2-460 |
6.93e-180 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 511.62 E-value: 6.93e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 2 RRLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFA 81
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 82 EGSIQLKNGESFVLD-SDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVS 160
Cdd:PRK05826 81 EGKITLKTGDKFTLDtDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 161 LPDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIR----GRASVMAKIEKPQAIDRLPEIIEVSDA 236
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLReagcPHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 237 LMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGK 316
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 317 FPVEAVSTMNRIGEEVERDPTYrgVLTAQRA-EPEPTVGDAIADAARQIAETL-DLSAIICWTSSGSTALRVARERPKPP 394
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKEFSI--NLSKHRLdRQFDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAP 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2050194471 395 VVAITPNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPG 460
Cdd:PRK05826 399 IFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
5-471 |
9.46e-177 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 508.31 E-value: 9.46e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 5 RRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEGS 84
Cdd:PRK06354 8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDGP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 85 IQLKNGESFVLDSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPE--RAVTRVVIGGKMSDRKGVSLP 162
Cdd:PRK06354 88 IELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKAdgELHCKVLVGGVLSNKKGVNFP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 163 DTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRAS----VMAKIEKPQAIDRLPEIIEVSDALM 238
Cdd:PRK06354 168 GVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGkhipIIAKIEKQEAIDNIDAILELCDGLM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 239 VARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFP 318
Cdd:PRK06354 248 VARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDYP 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 319 VEAVSTMNRIGEEVERDPTYRGVLTaQRAEPEPTVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAI 398
Cdd:PRK06354 328 VEAVQTMATIAVRIEKDLPYRDILS-KRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILAV 406
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2050194471 399 TPNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRIASVG 471
Cdd:PRK06354 407 TPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVG 479
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
5-467 |
2.14e-167 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 480.24 E-value: 2.14e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 5 RRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEGS 84
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 85 IQLKNGESFVLDSD--KTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVSLP 162
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 163 DTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIR----GRASVMAKIEKPQAIDRLPEIIEVSDALM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGekgaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 239 VARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 319 VEAVSTMNRIGEEVERDPTYRGVLT-AQRAEPEP-TVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVV 396
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNdRKNSDPKPsTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2050194471 397 AITPNLATGRKLSAVWGVHCVVAED-AKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRI 467
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
4-470 |
1.18e-150 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 437.90 E-value: 1.18e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 4 LRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEG 83
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 84 S-IQLKNGESFVLDSD--KTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAV-TRVVIGGKMSDRKGV 159
Cdd:cd00288 81 KdISLKAGDKFLVTTDpaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTLvCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 160 SLPDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRAS---VMAKIEKPQAIDRLPEIIEVSDA 236
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKdikIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 237 LMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGK 316
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 317 FPVEAVSTMNRIGEEVERDPTYRGVLTAQR-AEPEPT-VGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPP 394
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRrLTPRPTsTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 395 VVAITPNLATGRKLSAVWGVHCVVAEDAK-----DLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTpGTTNMVRIAS 469
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRILT 479
|
.
gi 2050194471 470 V 470
Cdd:cd00288 480 V 480
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
4-467 |
7.40e-117 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 351.28 E-value: 7.40e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 4 LRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEG 83
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 84 S-IQLKNGESFVLDSDKT-PGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVSL 161
Cdd:PRK09206 81 NdVSLKAGQTFTFTTDKSvVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 162 PDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRG----RASVMAKIEKPQAIDRLPEIIEVSDAL 237
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhggeNIQIISKIENQEGLNNFDEILEASDGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 238 MVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKF 317
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 318 PVEAVSTMNRIGEEVERDPTYRgvLTAQRAEPEPTVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVA 397
Cdd:PRK09206 321 PLEAVSIMATICERTDRVMNSR--LESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 398 ITPNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVpLGTPGTTNMVRI 467
Cdd:PRK09206 399 LTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGA-LVPSGTTNTASV 467
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
4-342 |
3.22e-114 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 340.11 E-value: 3.22e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 4 LRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEG 83
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 84 S--IQLKNGESFVLDSD---KTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPE-RAVTRVVIGGKMSDRK 157
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDakyKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 158 GVSLPDTDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRG---RASVMAKIEKPQAIDRLPEIIEVS 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEagkNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 235 DALMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAA 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|....*...
gi 2050194471 315 GKFPVEAVSTMNRIGEEVERDPTYRGVL 342
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
3-470 |
1.41e-101 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 313.62 E-value: 1.41e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 3 RLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRnvESSYGRP---IGILVDLQGPKLRLGS 79
Cdd:PTZ00066 36 RQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVR--EAAKARPnanLGILLDTKGPEIRTGF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 80 FAEGS-IQLKNGESFVLDSDKT-PGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRK 157
Cdd:PTZ00066 114 LKNHKpITLKEGQTLKITTDYTfLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 158 GVSLPD--TDLPVsaMTPKDRAD-LEAALVTGIDWVALSFVQRAEDVIEAKKLI--RGR-ASVMAKIEKPQAIDRLPEII 231
Cdd:PTZ00066 194 NMNLPGvkVELPV--IGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLgeRGRhIKIIPKIENIEGLINFDEIL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 232 EVSDALMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAE 311
Cdd:PTZ00066 272 AESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGE 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 312 SAAGKFPVEAVSTMNRIGEEVERDPTYRGVLTAQRAEPEP--TVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARE 389
Cdd:PTZ00066 352 TANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTpvSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKY 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 390 RPKPPVVAITPNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRIAS 469
Cdd:PTZ00066 432 RPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKVVK 511
|
.
gi 2050194471 470 V 470
Cdd:PTZ00066 512 I 512
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
1-404 |
1.48e-90 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 284.95 E-value: 1.48e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 1 MRRLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSF 80
Cdd:PLN02461 17 GLRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 81 AEGS-IQLKNGESFVLDSD-KTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVI--GGKMSDR 156
Cdd:PLN02461 97 KDGKpVQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCenSAMLGER 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 157 KGVSLPDT--DLPvsAMTPKDRAD-LEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRA---SVMAKIEKPQAIDRLPEI 230
Cdd:PLN02461 177 KNVNLPGVvvDLP--TLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAksiLLISKVENQEGLDNFDDI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 231 IEVSDALMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSA 310
Cdd:PLN02461 255 LAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 311 ESAAGKFPVEAVSTMNRIGEEVER----DPTYRGVLTAQRAEPEPTvgDAIADAARQIAETLDLSAIICWTSSGSTALRV 386
Cdd:PLN02461 335 ETAAGAYPELAVKTMARICREAEAsldyGALFKEIMRSAPLPMSPL--ESLASSAVRTANKVKASLIVVLTRGGTTARLV 412
|
410
....*....|....*....
gi 2050194471 387 ARERPKPPVVA-ITPNLAT 404
Cdd:PLN02461 413 AKYRPAVPILSvVVPEITT 431
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-333 |
1.83e-90 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 279.52 E-value: 1.83e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 7 IKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSygrpIGILVDLQGPKLRLGSFAEGSIQ 86
Cdd:PRK06739 3 IDRICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----IKILGDVQGPKIRLGEIKGEQIT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 87 LKNGESFVLDSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVSLPDTDL 166
Cdd:PRK06739 79 LQAGDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 167 PVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGR----ASVMAKIEKPQAIDRLPEIIEVSDALMVARG 242
Cdd:PRK06739 159 RLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYketsPNLIAKIETMEAIENFQDICKEADGIMIARG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 243 DLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPVEAV 322
Cdd:PRK06739 239 DLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESV 318
|
330
....*....|.
gi 2050194471 323 STMNRIGEEVE 333
Cdd:PRK06739 319 STLRLVSEFAE 329
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
33-451 |
1.07e-85 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 270.77 E-value: 1.07e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 33 VFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFAEGSIQLKNGESFVLDSD---KTPGDHSRIQL 109
Cdd:PTZ00300 3 VARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDpafADKGTKDKFYI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 110 PHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGK-MSDRKGVSLPDTDLPVSAMTPKDRADLEAALVTGID 188
Cdd:PTZ00300 83 DYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQTLKCTVTNAHtISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQGVD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 189 WVALSFVQRAEDVIEAKKLIRGRAS---VMAKIEKPQAIDRLPEIIEVSDALMVARGDLGVELPLERVPSLQKQMTRLAR 265
Cdd:PTZ00300 163 MIFASFIRSAEQVGEVRKALGAKGGdimIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCN 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 266 RAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPVEAVSTMNRIGEEVERDPT-YRGVLTA 344
Cdd:PTZ00300 243 VAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNeYVFFNSI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 345 QRAEPEP-TVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAITPNLATGRKLSAVWGVHCVVAeDAK 423
Cdd:PTZ00300 323 KKLQPIPmSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF-DAE 401
|
410 420 430
....*....|....*....|....*....|....
gi 2050194471 424 DL------DDMVSRAGSIAFRDGFARAGQRVIIV 451
Cdd:PTZ00300 402 RLghdegkEQRVAMGVGFAKSKGYVQSGDLMVVV 435
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
2-458 |
1.05e-84 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 269.69 E-value: 1.05e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 2 RRLRRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSF- 80
Cdd:PLN02762 22 RSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLg 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 81 AEGSIQLKNGESFVLDSDKTPGDHSR--IQLPHPEILAALRPGHALLLDDGKVRL-IAEETSPE-------------RAV 144
Cdd:PLN02762 102 GASSAKAEDGEEWTFTVRKFDGSRPEftIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPDvkckctdpglllpRAN 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 145 TRVVIGGKMSDRKGVSLPdtdlpvsAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRAS-----VMAKIE 219
Cdd:PLN02762 182 LTFWRDGSLVRERNAMLP-------TISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRdsdigVIAKIE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 220 KPQAIDRLPEIIEVSDALMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAV 299
Cdd:PLN02762 255 SLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAV 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 300 YDGADAIMLSAESAAGKFPVEAVSTMNRIGEEVERdptYRGVLTAQRAEPEPTVGDAIAD--------AARQIAETLDLS 371
Cdd:PLN02762 335 RQRADALMLSGESAMGLYPEKALSVLRSVSLRMEL---WSREEKRHEALELPQLSSSLSDriseeicnSAAKMANNLGVD 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 372 AIICWTSSGSTALRVARERPKPPVVAITPNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIV 451
Cdd:PLN02762 412 AIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAV 491
|
....*..
gi 2050194471 452 AGVPLGT 458
Cdd:PLN02762 492 SDLTPSS 498
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
5-451 |
9.99e-81 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 261.40 E-value: 9.99e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 5 RRIKILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVES-SYGRPIGILVDLQGPKLRLGSFAEg 83
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAqSKDNVIAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 84 SIQLKNGESFVLDSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVVIGGKMSDRKGVSLPD 163
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 164 TDLPVSAMTPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIRGRA---SVMAKIEKPQAIDRLPEIIEVSDALMVA 240
Cdd:PLN02623 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNadiHVIVKIESADSIPNLHSIITASDGAMVA 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 241 RGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPVE 320
Cdd:PLN02623 349 RGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 321 AVSTMNRIGEEVERDPTYRGVLTAQRAEPEPTVGDAIADAARQIAETLDlSAIICWTSSGSTALRVARERPKPPVVAITP 400
Cdd:PLN02623 429 AVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLG-TSIIVFTRTGFMAILLSHYRPSGTIFAFTN 507
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2050194471 401 NLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGSIAFRDGFARAGQRVIIV 451
Cdd:PLN02623 508 EKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALV 558
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-328 |
3.25e-63 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 212.95 E-value: 3.25e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 2 RRLRRIKILATL-GPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSF 80
Cdd:PRK08187 130 PAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 81 AE--GSIQLKNGESFVL----DSDKTPGDHSRIQLPHPEILAALRPGHALLLDDGKVRLIAEETSPERAVTRVV----IG 150
Cdd:PRK08187 210 AGplGKTRLYTGDRLALvaqgPPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTharpKG 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 151 GKMSDRKGVSLPDTDLPVSAMTPKDRADLeAALVTGIDWVALSFVQRAEDV------IEAKK-LIRGRASVMAKIEKPQA 223
Cdd:PRK08187 290 LKLKPEKGLNFPDTALDLPALTEKDRADL-DFVARHADLVGYSFVQSPGDVealqaaLAARRpDDWRKLGLVLKIETPRA 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 224 IDRLPEIIEVSD-----ALMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATA 298
Cdd:PRK08187 369 VANLPELIVQAAgrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA 448
|
330 340 350
....*....|....*....|....*....|
gi 2050194471 299 vyDGADAIMLSaesaAGKFPVEAVSTMNRI 328
Cdd:PRK08187 449 --ARAECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
8-467 |
2.62e-58 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 200.67 E-value: 2.62e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 8 KILATLGPASSDSAMIRRLFEAGADVFRINMSHTSHD----TMRELVKTIRNVEssygRPIGILVDLQGPKLRLGSFAEG 83
Cdd:PLN02765 31 KIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEyhqeTLENLKIAVKNTK----KLCAVMLDTVGPELQVINKTEK 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 84 SIQLKNGESFVLDSDKTPGDHSRIqLP--HPEILAALRPGHALLL--------DDGKVRLIAEETSPERAVTRV----VI 149
Cdd:PLN02765 107 PISLKAGNTVTLTPDQSKEASSEV-LPinFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVknsaTL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 150 GGKM----SDRKGVSLPdtdlpvsAMTPKDRADLEA-ALVTGIDWVALSFVQRAEDVIEAKKLIR----GRASVMAKIEK 220
Cdd:PLN02765 186 AGSLftlhVSQVRIDLP-------TLSEKDKEVISTwGVPNKIDFLSLSYTRHAEDVREAREFLSslglSQTQIFAKIEN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 221 PQAIDRLPEIIEVSDALMVARGDLGVELPLERVPSLQKQMTRLARRAGKPVVIaTQMLESMIQSPVPTRAEVSDVATAVY 300
Cdd:PLN02765 259 VEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 301 DGADAIMLSAESAAGKFPVEAVSTMNRIGEEVER----DPTYRGVLtaqraepePTVGD------AIADAARQIAETLDL 370
Cdd:PLN02765 338 DGADAILLGAETLRGLYPVETISTVGRICAEAEKvfnqDLYFKKTV--------KYVGEpmshleSIASSAVRAAIKVKA 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 371 SAIICWTSSGSTALRVARERPKPPVVA-ITPNLAT------------GRKLSAVWGVHCVVAEDAKDLDDMVSRAGSI-- 435
Cdd:PLN02765 410 SVIIVFTSSGRAARLIAKYRPTMPVLSvVIPRLKTnqlkwsftgafqARQCLIVRGLFPMLADPRHSAESTSATNESVlk 489
|
490 500 510
....*....|....*....|....*....|....*..
gi 2050194471 436 -----AFRDGFARAGQRVIIVAGVplgtpGTTNMVRI 467
Cdd:PLN02765 490 valdhGKAAGVIKSHDRVVVCQKV-----GDSSVVKI 521
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
264-471 |
1.48e-57 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 193.19 E-value: 1.48e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 264 ARRAGKPVVIATQMLESMIQSPVPTRAEVSDVATAVYDGADAIMLSAESAAGKFPVEAVSTMNRIGEEVERDPTYRGVLT 343
Cdd:COG3848 2 CNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 344 AQRAEPEPTVGDAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAITPNLATGRKLSAVWGVHCVVAEDAK 423
Cdd:COG3848 82 PRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESA 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2050194471 424 DLDDMVSRAGSIAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRIASVG 471
Cdd:COG3848 162 STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVG 209
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
5-334 |
5.72e-50 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 179.76 E-value: 5.72e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 5 RRIKILATL-GPASSDSAMIRRLFEAGADVFRINMSHTSHDTMRELVKTIRNVESSYGRPIGILVDLQGPKLRLGSFA-- 81
Cdd:PRK14725 139 RPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIApg 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 --------------------------------------------------------------------------------
Cdd:PRK14725 219 prviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvtevddegvl 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 82 -------------------------------EGSIQLKNGESFVLDSDKTPGD--HSRIQLPH-----PEILAALRPGHA 123
Cdd:PRK14725 299 aegsqtaylangtllrlgrhdstrvgglppvEQKLRLKVGDRLVLTRDDAPGDpaQGDAPPARisctlPEAFRAARVGER 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 124 LLLDDGKVRLIAEETSPERAVTRVV----IGGKMSDRKGVSLPDTDLPVSAMTPKDRADLeAALVTGIDWVALSFVQRAE 199
Cdd:PRK14725 379 VWFDDGKIGAVVVKVEADEVELRITharpGGSKLKAGKGINLPDSHLPLPALTDKDLEDL-AFVAKHADIVALSFVRSPE 457
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 200 DVI----EAKKLIRGRASVMAKIEKPQAIDRLPEIIevSDAL-------MVARGDLGVELPLERVPSLQKQMTRLARRAG 268
Cdd:PRK14725 458 DVRllldALEKLGADDLGVVLKIETRRAFENLPRIL--LEAMrhprfgvMIARGDLAVEVGFERLAEVQEEILWLCEAAH 535
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2050194471 269 KPVVIATQMLESMIQSPVPTRAEVSDVATAVYdgADAIMLSaesaAGKFPVEAVSTMNRIGEEVER 334
Cdd:PRK14725 536 VPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE 595
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
355-467 |
1.66e-42 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 146.47 E-value: 1.66e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 355 DAIADAARQIAETLDLSAIICWTSSGSTALRVARERPKPPVVAITPNLATGRKLSAVWGVHCVVAEDAKDLDDMVSRAGS 434
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|...
gi 2050194471 435 IAFRDGFARAGQRVIIVAGVPLGTPGTTNMVRI 467
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
|
|
| CitE |
COG2301 |
Citrate lyase beta subunit [Carbohydrate transport and metabolism]; |
172-272 |
4.95e-03 |
|
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
Pssm-ID: 441876 Cd Length: 288 Bit Score: 38.98 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050194471 172 TPKDRADLEAALVTGIDWVALSFVQRAEDVIEAKKLIR------GRASVMAKIEKPQAIDRLPEIIEVSDALMVAR---- 241
Cdd:COG2301 74 TPWGLDDLAALVGAGLDGIVLPKVESAEDVRALAALLTeleaegGSIPLMALIETARGLLNAAEIAAASPRVEALVfgae 153
|
90 100 110
....*....|....*....|....*....|....*.
gi 2050194471 242 ---GDLGVELPLERVPSLQ-KQMTRLA-RRAGKPVV 272
Cdd:COG2301 154 dlaADLGARRTRDGDELLYaRSRIVLAaRAAGLAAI 189
|
|
| |
