Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
763-827
1.44e-05
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
:
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 44.11 E-value: 1.44e-05
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
651-735
7.05e-14
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 67.61 E-value: 7.05e-14
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
763-827
1.44e-05
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 44.11 E-value: 1.44e-05
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
640-759
4.23e-05
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.
Pssm-ID: 468234 [Multi-domain] Cd Length: 533 Bit Score: 47.44 E-value: 4.23e-05
TQXA domain; This model describes a domain of about 40 residues with an invariant TQ dipeptide ...
100-132
5.22e-04
TQXA domain; This model describes a domain of about 40 residues with an invariant TQ dipeptide in an almost invariant TQxA[VI]W motif. This domain occurs in surface-expressed proteins of Gram-positive bacteria, many of which are anchored by LPXTG-containing sortase target domains. Numerous members of this family have domains pfam05738 (Cna protein B-type domain) and pfam08341 (fibronectin-binding protein signal sequence).
Pssm-ID: 274864 [Multi-domain] Cd Length: 42 Bit Score: 38.77 E-value: 5.22e-04
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
651-735
7.05e-14
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 67.61 E-value: 7.05e-14
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
325-391
3.10e-10
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 57.21 E-value: 3.10e-10
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
549-623
3.90e-09
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 54.13 E-value: 3.90e-09
Thioester domain; This domain is found near the N-terminus of a variety of bacterial surface ...
67-177
2.19e-07
Thioester domain; This domain is found near the N-terminus of a variety of bacterial surface proteins and pili. This domain contains an unusual covalent ester bond between a conserved cysteine and glutamine residue.
Pssm-ID: 462437 [Multi-domain] Cd Length: 105 Bit Score: 50.31 E-value: 2.19e-07
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
234-295
2.35e-06
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 46.04 E-value: 2.35e-06
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
763-827
1.44e-05
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 44.11 E-value: 1.44e-05
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
640-759
4.23e-05
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.
Pssm-ID: 468234 [Multi-domain] Cd Length: 533 Bit Score: 47.44 E-value: 4.23e-05
TQXA domain; This model describes a domain of about 40 residues with an invariant TQ dipeptide ...
100-132
5.22e-04
TQXA domain; This model describes a domain of about 40 residues with an invariant TQ dipeptide in an almost invariant TQxA[VI]W motif. This domain occurs in surface-expressed proteins of Gram-positive bacteria, many of which are anchored by LPXTG-containing sortase target domains. Numerous members of this family have domains pfam05738 (Cna protein B-type domain) and pfam08341 (fibronectin-binding protein signal sequence).
Pssm-ID: 274864 [Multi-domain] Cd Length: 42 Bit Score: 38.77 E-value: 5.22e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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