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Conserved domains on  [gi|2059325136|ref|WP_217084766|]
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phenylalanine--tRNA ligase subunit beta [Burkholderia multivorans]

Protein Classification

phenylalanine--tRNA ligase subunit beta( domain architecture ID 11479069)

phenylalanine--tRNA ligase subunit beta is part of the enzyme complex that catalyzes the attachment of phenylalanine to tRNA(Phe)

CATH:  2.40.50.140|3.50.40.10|3.30.56.10|3.30.930.10|3.30.70.380
EC:  6.1.1.20
Gene Ontology:  GO:0005737|GO:0000049|GO:0005524|GO:0006432|GO:0000287|GO:0004826
PubMed:  14665676|8274143|11310981

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
 1-809 0e+00

phenylalanyl-tRNA synthetase subunit beta; Reviewed


:

Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 1057.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTTDELSHALTMAGLEVESLSKAAPPTSKIVVGRVLEVVKHPDADKLNVCQVDAGAGaTLNIVCG 80
Cdd:PRK00629    1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVGEE-PLQIVCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  81 APNVAPGIKVPVALVGAELPpaeeGGkpFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNLD 160
Cdd:PRK00629   80 APNVRAGDKVPVALPGAVLP----GG--FKIKKAKLRGVESEGMLCSASELGLSDDHDGIIELPEDAPVGTDAREYLGLD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 161 DTIFEIKLTPNKADCLSVFGIARETAAITGAPLTPVEIRPAPVELDETLPVRISAPDLCGRFSGRVIRGVNARAKTPQWM 240
Cdd:PRK00629  154 DTVIEISLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 241 VERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVESLA 320
Cdd:PRK00629  234 QERLRAAGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 321 GIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGGKAGPVDDQ 400
Cdd:PRK00629  314 GVMGGEDSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEVVEGVVD 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 401 AVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFER-DGDVFSVTPPSHRFdieieedlieeVARIYGFEKIP 479
Cdd:PRK00629  394 VYPLPKEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVTEvDGDGLTVTVPSWRFdieieedlveeVARIYGYDNIP 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 480 ARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAEWERDFAGNDNPIRLLNPIASQLSVMRTTLFGSLIAV 559
Cdd:PRK00629  474 STPPVAALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEA 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 560 LRHNLNRRADRVRVFETGRVFIADpsvkageltVEGYAQPKRVGALAYGPAFDEQWGIAtRAVDFFDVKGD----LEALL 635
Cdd:PRK00629  554 VAYNLNRGNKDVALFEIGRVFLPD---------GDLPREPEHLAGVLTGNRVEESWGGK-RPVDFFDLKGDvealLEALG 623

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 636 APAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALI--ARALPALTDVSKFPPVR 713
Cdd:PRK00629  624 LPEVEFVAEFEAAALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALLeaARKLPKYKPISKFPAVR 703

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 714 RDIAVVVDQAVEVQTLFDEMKQAladdACRFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQDEVVDQAI 793
Cdd:PRK00629  704 RDLALVVDEDVPAADILKAIKKA----GGKLLESVELFDVYEGK-----GIGEGKKSLAFRLTFQDPDRTLTDEEINAAM 774

                         810
                  ....*....|....*..
gi 2059325136 794 QTLVERMARA-GARLRG 809
Cdd:PRK00629  775 DKIVAALEEKfGAELRG 791
 
Name Accession Description Interval E-value
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
 1-809 0e+00

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 1057.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTTDELSHALTMAGLEVESLSKAAPPTSKIVVGRVLEVVKHPDADKLNVCQVDAGAGaTLNIVCG 80
Cdd:PRK00629    1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVGEE-PLQIVCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  81 APNVAPGIKVPVALVGAELPpaeeGGkpFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNLD 160
Cdd:PRK00629   80 APNVRAGDKVPVALPGAVLP----GG--FKIKKAKLRGVESEGMLCSASELGLSDDHDGIIELPEDAPVGTDAREYLGLD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 161 DTIFEIKLTPNKADCLSVFGIARETAAITGAPLTPVEIRPAPVELDETLPVRISAPDLCGRFSGRVIRGVNARAKTPQWM 240
Cdd:PRK00629  154 DTVIEISLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 241 VERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVESLA 320
Cdd:PRK00629  234 QERLRAAGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 321 GIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGGKAGPVDDQ 400
Cdd:PRK00629  314 GVMGGEDSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEVVEGVVD 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 401 AVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFER-DGDVFSVTPPSHRFdieieedlieeVARIYGFEKIP 479
Cdd:PRK00629  394 VYPLPKEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVTEvDGDGLTVTVPSWRFdieieedlveeVARIYGYDNIP 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 480 ARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAEWERDFAGNDNPIRLLNPIASQLSVMRTTLFGSLIAV 559
Cdd:PRK00629  474 STPPVAALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEA 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 560 LRHNLNRRADRVRVFETGRVFIADpsvkageltVEGYAQPKRVGALAYGPAFDEQWGIAtRAVDFFDVKGD----LEALL 635
Cdd:PRK00629  554 VAYNLNRGNKDVALFEIGRVFLPD---------GDLPREPEHLAGVLTGNRVEESWGGK-RPVDFFDLKGDvealLEALG 623

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 636 APAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALI--ARALPALTDVSKFPPVR 713
Cdd:PRK00629  624 LPEVEFVAEFEAAALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALLeaARKLPKYKPISKFPAVR 703

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 714 RDIAVVVDQAVEVQTLFDEMKQAladdACRFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQDEVVDQAI 793
Cdd:PRK00629  704 RDLALVVDEDVPAADILKAIKKA----GGKLLESVELFDVYEGK-----GIGEGKKSLAFRLTFQDPDRTLTDEEINAAM 774

                         810
                  ....*....|....*..
gi 2059325136 794 QTLVERMARA-GARLRG 809
Cdd:PRK00629  775 DKIVAALEEKfGAELRG 791
PheT COG0072
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ...
 1-809 0e+00

Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439842 [Multi-domain]  Cd Length: 793  Bit Score: 993.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTTDELSHALTMAGLEVESLSKAAPPTSKIVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCG 80
Cdd:COG0072     1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  81 APNVAPGIKVPVALVGAELPpaeeggKPFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNLD 160
Cdd:COG0072    81 AANVAVGVVVVAAPGGAVLP------GGFKIKKAKIRGVESSGMLCSEEELGLGEDHDGIIVLPPDAPVGGDAREYLGLD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 161 DTIFEIKLTPNKADCLSVFGIARETAAITGAPLTPVEIRP-APVELDETLPVRISAPDLCGRFSGRVIRGVNArAKTPQW 239
Cdd:COG0072   155 DTVLEIDLTPNRADCLSVRGVARELAALLGAPLKLPAIEPeVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKV-GPSPLW 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 240 MVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVESL 319
Cdd:COG0072   234 MQERLRAAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLAL 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 320 AGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGGKAGP-VD 398
Cdd:COG0072   314 AGVMGGEDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIV 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 399 DQAVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFERDGDVFSVTPPSHRFdieieedlieeVARIYGFEKI 478
Cdd:COG0072   394 DVYPEPPEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFdieieadlieeVARIYGYDNI 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 479 PARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAEWERDFAGNDNPIRLLNPIASQLSVMRTTLFGSLIA 558
Cdd:COG0072   474 PSTLPRAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLE 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 559 VLRHNLNRRADRVRVFETGRVFIADPSvkageltvEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGDLE---ALL 635
Cdd:COG0072   554 AAAYNLNRGQKDVRLFEIGRVFLPDEG--------EEPREPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEallAAL 625

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 636 APAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALI--ARALPALTDVSKFPPVR 713
Cdd:COG0072   626 GVPKLEFEAAEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALLelARKVPKYKPISKFPAVR 705

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 714 RDIAVVVDQAVEVQTLFDEMKQAladdACRFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQDEVVDQAI 793
Cdd:COG0072   706 RDLALVVDEDVPAADVLDAIRKA----AGKLLEDVRLFDVYEGK-----GVPEGKKSLAFSLTLQDPDRTLTDEEIDAAM 776

                         810
                  ....*....|....*..
gi 2059325136 794 QTLVERMARA-GARLRG 809
Cdd:COG0072   777 DKIVAALEKKfGAELRG 793
pheT_bact TIGR00472
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ...
 1-808 0e+00

phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273097 [Multi-domain]  Cd Length: 797  Bit Score: 764.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTT-DELSHALTMAGLEVESLSKAAPPTSKIVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVC 79
Cdd:TIGR00472   1 MKISLKWLREYVPLSEIDnEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  80 GAPNVAPGIKVPVALVGAELPpaeeggKPFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNL 159
Cdd:TIGR00472  81 GAPNVEAGKKVAVALPGAKLP------NGLKIKKSKLRGVESEGMLCSESELGLDEKSDGIIVLDEDAPLGTDIAEYLGL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 160 DDTIFEIKLTPNKADCLSVFGIARETAAITGAPL-TPVEIRPAPVE-LDETLPVRISAPDLCGRFSGRVIRGVNArAKTP 237
Cdd:TIGR00472 155 DDDIIEVSITPNRGDCLSILGIARELAALFDLNLeTPVPFEPETTEtIDEGFKIEIEDPEVCPFYLGRVIKGVKV-KPSP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 238 QWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVE 317
Cdd:TIGR00472 234 LWLKERLRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPL 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 318 SLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGG-KAGP 396
Cdd:TIGR00472 314 AIAGVMGGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGeVISV 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 397 VDDQAVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFERDGDVFSVTPPSHRFDIEIEEDLIEEVARIYGFE 476
Cdd:TIGR00472 394 VSDNYKEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYD 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 477 KIPARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAE--WERDFAGNDNPIRLLNPIASQLSVMRTTLFG 554
Cdd:TIGR00472 474 NIPAEPLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPEkaEKFNFPKLENLVEIKNPLSNERSVLRTSLLP 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 555 SLIAVLRHNLNRRADRVRVFETGRVFIADPsvkageltvEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGD---- 630
Cdd:TIGR00472 554 SLLEVLAYNQNRKNKDVKIFEIGKVFAKDG---------EAVKEQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDvesl 624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 631 -LEALLAPAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALI--ARALPALTDVS 707
Cdd:TIGR00472 625 lELLGLSDDVYFKNTAENEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLLesLKKVPKYRPIS 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 708 KFPPVRRDIAVVVDQAVEVQTLFDEMKQALADdacrFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQDE 787
Cdd:TIGR00472 705 KFPAVTRDISFLVPKDVPANEIIKLIKKSGLE----LLEEVELFDVYQGK-----NIGEGKKSLALRLVLRDKERTLTDE 775

                         810       820
                  ....*....|....*....|..
gi 2059325136 788 VVDQAIQTLVERMAR-AGARLR 808
Cdd:TIGR00472 776 EINKIVEKVLNALKEkLGAELR 797
B3_4 pfam03483
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 218-391 3.87e-82

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 427327 [Multi-domain]  Cd Length: 174  Bit Score: 260.17  E-value: 3.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 218 LCGRFSGRVIRGVNARAKTPQWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLN 297
Cdd:pfam03483   1 ACPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 298 GNTVELDETVGVIADDRQVESLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVE 377
Cdd:pfam03483  81 GKERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEA 160

                         170
                  ....*....|....
gi 2059325136 378 HVERITQLILEICG 391
Cdd:pfam03483 161 ALDRATALLLELCG 174
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 219-391 5.23e-68

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 222.52  E-value: 5.23e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  219 CGRFSGRVIRGVNARAKTPQWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGG-IEVRWGKRGESLKLLN 297
Cdd:smart00873   1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  298 GNTVELDETVGVIADDRQVESLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVE 377
Cdd:smart00873  81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160

                          170
                   ....*....|....
gi 2059325136  378 HVERITQLILEICG 391
Cdd:smart00873 161 ALDRAAALLLEICG 174
PheRS_beta_core cd00769
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ...
 502-695 2.59e-60

Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.


Pssm-ID: 238392 [Multi-domain]  Cd Length: 198  Bit Score: 202.49  E-value: 2.59e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 502 IRHALAARDYAETVNFSFVDAEWERDFA-GNDNPIRLLNPIASQLSVMRTTLFGSLIAVLRHNLNRRADRVRVFETGRVF 580
Cdd:cd00769     9 LRRLLAGLGFQEVITYSLTSPEEAELFDgGLDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLRLFEIGRVF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 581 IADPsvkageltvEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGDLEA--LLAPAAARFVKAEHPA--LHPGRSA 656
Cdd:cd00769    89 LKDE---------DGPEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEAllRALGIIVEFELEELDAdlFHPGRSA 159

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2059325136 657 RIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADAL 695
Cdd:cd00769   160 KIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
 
Name Accession Description Interval E-value
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
 1-809 0e+00

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 1057.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTTDELSHALTMAGLEVESLSKAAPPTSKIVVGRVLEVVKHPDADKLNVCQVDAGAGaTLNIVCG 80
Cdd:PRK00629    1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVGEE-PLQIVCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  81 APNVAPGIKVPVALVGAELPpaeeGGkpFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNLD 160
Cdd:PRK00629   80 APNVRAGDKVPVALPGAVLP----GG--FKIKKAKLRGVESEGMLCSASELGLSDDHDGIIELPEDAPVGTDAREYLGLD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 161 DTIFEIKLTPNKADCLSVFGIARETAAITGAPLTPVEIRPAPVELDETLPVRISAPDLCGRFSGRVIRGVNARAKTPQWM 240
Cdd:PRK00629  154 DTVIEISLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 241 VERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVESLA 320
Cdd:PRK00629  234 QERLRAAGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 321 GIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGGKAGPVDDQ 400
Cdd:PRK00629  314 GVMGGEDSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEVVEGVVD 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 401 AVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFER-DGDVFSVTPPSHRFdieieedlieeVARIYGFEKIP 479
Cdd:PRK00629  394 VYPLPKEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVTEvDGDGLTVTVPSWRFdieieedlveeVARIYGYDNIP 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 480 ARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAEWERDFAGNDNPIRLLNPIASQLSVMRTTLFGSLIAV 559
Cdd:PRK00629  474 STPPVAALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEA 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 560 LRHNLNRRADRVRVFETGRVFIADpsvkageltVEGYAQPKRVGALAYGPAFDEQWGIAtRAVDFFDVKGD----LEALL 635
Cdd:PRK00629  554 VAYNLNRGNKDVALFEIGRVFLPD---------GDLPREPEHLAGVLTGNRVEESWGGK-RPVDFFDLKGDvealLEALG 623

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 636 APAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALI--ARALPALTDVSKFPPVR 713
Cdd:PRK00629  624 LPEVEFVAEFEAAALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALLeaARKLPKYKPISKFPAVR 703

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 714 RDIAVVVDQAVEVQTLFDEMKQAladdACRFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQDEVVDQAI 793
Cdd:PRK00629  704 RDLALVVDEDVPAADILKAIKKA----GGKLLESVELFDVYEGK-----GIGEGKKSLAFRLTFQDPDRTLTDEEINAAM 774

                         810
                  ....*....|....*..
gi 2059325136 794 QTLVERMARA-GARLRG 809
Cdd:PRK00629  775 DKIVAALEEKfGAELRG 791
PheT COG0072
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ...
 1-809 0e+00

Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439842 [Multi-domain]  Cd Length: 793  Bit Score: 993.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTTDELSHALTMAGLEVESLSKAAPPTSKIVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCG 80
Cdd:COG0072     1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  81 APNVAPGIKVPVALVGAELPpaeeggKPFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNLD 160
Cdd:COG0072    81 AANVAVGVVVVAAPGGAVLP------GGFKIKKAKIRGVESSGMLCSEEELGLGEDHDGIIVLPPDAPVGGDAREYLGLD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 161 DTIFEIKLTPNKADCLSVFGIARETAAITGAPLTPVEIRP-APVELDETLPVRISAPDLCGRFSGRVIRGVNArAKTPQW 239
Cdd:COG0072   155 DTVLEIDLTPNRADCLSVRGVARELAALLGAPLKLPAIEPeVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKV-GPSPLW 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 240 MVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVESL 319
Cdd:COG0072   234 MQERLRAAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLAL 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 320 AGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGGKAGP-VD 398
Cdd:COG0072   314 AGVMGGEDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIV 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 399 DQAVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFERDGDVFSVTPPSHRFdieieedlieeVARIYGFEKI 478
Cdd:COG0072   394 DVYPEPPEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFdieieadlieeVARIYGYDNI 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 479 PARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAEWERDFAGNDNPIRLLNPIASQLSVMRTTLFGSLIA 558
Cdd:COG0072   474 PSTLPRAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLE 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 559 VLRHNLNRRADRVRVFETGRVFIADPSvkageltvEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGDLE---ALL 635
Cdd:COG0072   554 AAAYNLNRGQKDVRLFEIGRVFLPDEG--------EEPREPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEallAAL 625

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 636 APAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALI--ARALPALTDVSKFPPVR 713
Cdd:COG0072   626 GVPKLEFEAAEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALLelARKVPKYKPISKFPAVR 705

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 714 RDIAVVVDQAVEVQTLFDEMKQAladdACRFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQDEVVDQAI 793
Cdd:COG0072   706 RDLALVVDEDVPAADVLDAIRKA----AGKLLEDVRLFDVYEGK-----GVPEGKKSLAFSLTLQDPDRTLTDEEIDAAM 776

                         810
                  ....*....|....*..
gi 2059325136 794 QTLVERMARA-GARLRG 809
Cdd:COG0072   777 DKIVAALEKKfGAELRG 793
pheT_bact TIGR00472
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ...
 1-808 0e+00

phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273097 [Multi-domain]  Cd Length: 797  Bit Score: 764.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTT-DELSHALTMAGLEVESLSKAAPPTSKIVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVC 79
Cdd:TIGR00472   1 MKISLKWLREYVPLSEIDnEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  80 GAPNVAPGIKVPVALVGAELPpaeeggKPFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNL 159
Cdd:TIGR00472  81 GAPNVEAGKKVAVALPGAKLP------NGLKIKKSKLRGVESEGMLCSESELGLDEKSDGIIVLDEDAPLGTDIAEYLGL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 160 DDTIFEIKLTPNKADCLSVFGIARETAAITGAPL-TPVEIRPAPVE-LDETLPVRISAPDLCGRFSGRVIRGVNArAKTP 237
Cdd:TIGR00472 155 DDDIIEVSITPNRGDCLSILGIARELAALFDLNLeTPVPFEPETTEtIDEGFKIEIEDPEVCPFYLGRVIKGVKV-KPSP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 238 QWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVE 317
Cdd:TIGR00472 234 LWLKERLRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPL 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 318 SLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGG-KAGP 396
Cdd:TIGR00472 314 AIAGVMGGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGeVISV 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 397 VDDQAVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFERDGDVFSVTPPSHRFDIEIEEDLIEEVARIYGFE 476
Cdd:TIGR00472 394 VSDNYKEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYD 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 477 KIPARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAE--WERDFAGNDNPIRLLNPIASQLSVMRTTLFG 554
Cdd:TIGR00472 474 NIPAEPLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPEkaEKFNFPKLENLVEIKNPLSNERSVLRTSLLP 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 555 SLIAVLRHNLNRRADRVRVFETGRVFIADPsvkageltvEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGD---- 630
Cdd:TIGR00472 554 SLLEVLAYNQNRKNKDVKIFEIGKVFAKDG---------EAVKEQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDvesl 624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 631 -LEALLAPAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALI--ARALPALTDVS 707
Cdd:TIGR00472 625 lELLGLSDDVYFKNTAENEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLLesLKKVPKYRPIS 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 708 KFPPVRRDIAVVVDQAVEVQTLFDEMKQALADdacrFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQDE 787
Cdd:TIGR00472 705 KFPAVTRDISFLVPKDVPANEIIKLIKKSGLE----LLEEVELFDVYQGK-----NIGEGKKSLALRLVLRDKERTLTDE 775

                         810       820
                  ....*....|....*....|..
gi 2059325136 788 VVDQAIQTLVERMAR-AGARLR 808
Cdd:TIGR00472 776 EINKIVEKVLNALKEkLGAELR 797
EMAP COG0073
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
1-779 2.39e-147

tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439843 [Multi-domain]  Cd Length: 773  Bit Score: 451.62  E-value: 2.39e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136   1 MQFPESWLRTFVDPQMTTDELSHALTMAGLEVESLSKAAPPtSKIVVGRVLEVVKHPDADKLNVCQVDAGAGaTLNIVCG 80
Cdd:COG0073     1 MKVSLSWLKEYVDLDLSPEELAEKLTMAGIEVEDFEKVGGL-DGLRVGKVLEAEPHPNADKLLVLQVDVGEE-TRQIVCG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  81 APNVAPGIKVPVALVGAELPpaeeggKPFAIKLSKLRGVESQGMLCSARELKLSEDHSGLLILPEDTPVGQDIRDALNLD 160
Cdd:COG0073    79 APNVYAGDKVPEALVGAQVP------GVVNLKPRKIRGVESEGMLCSAEELGLGEDHDGILELPEDAPPGDDAEYLLLLD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 161 DTIFEIKLTPNKADCLSVFGIARETAAITGAPLTPvEIRPAPVELDETLPVRISAPDLCGRFSGRVIRGVNARAKTPQWM 240
Cdd:COG0073   153 DVIIEILTTPNRDDLLSVGGAAREAAALGGLLLKP-PAPPVVEGTDDAVLVVVVDDDACDRYYGRVVRGVVNVVVPPPPW 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 241 VERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVELDETVGVIADDRQVESLA 320
Cdd:COG0073   232 LRRLLRRGGRRRIINVVDINNVVLLLLGQPHHAFDDDDLGGGIVVRRRRAEELLLLLLGDTTLLLDDLLLIDDDDDALAA 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 321 GIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVEHVERITQLILEICGGKAGPV--- 397
Cdd:COG0073   312 AGGGGGGGGSSGSTTTTTLLLAAAAFFAAAGRRRRRRRLSSRSSRRRRREDDDDPRVAAAAAAAALLLIILGGGGGVagg 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 398 DDQAVNLPQRTPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFERDGDVFSVTPPSHRFDIEIEEDLIEEVARIYGFEK 477
Cdd:COG0073   392 VVDEGLPPPPPRIIRLRRRRRLLLLGIDIDEEELLLLLLLLGFEVEGEGESVVVPPPRRRDDVIEEDEEEEEARRYYYYD 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 478 IPARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAEWERDFAGNDNPIRLLNPIASQLSVMRTTLFGSLI 557
Cdd:COG0073   472 LPPPPPPAPPAVPEPPAARRRLRRRRRLLLLLGLEEAVTYSSFSELLLALLLLFEAALLLLLPPSSLSSSLLLSLLLLLL 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 558 AVLRHNLNRRADRVRVFETGRVFIADPSVKAGELTVEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGDleALLAP 637
Cdd:COG0073   552 LLVLLLLRRRNRNRRLFEGGEVFFGFEGGGLELLLAELEAGGALLLGGGGGAALGLAADDADDLAGVLLLLAL--LLGLL 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 638 AAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADALIARALPALTDVSKFPPVRRDIA 717
Cdd:COG0073   630 ALLALAAAAPAAAAPGAGGAGGLLLGGGGGLGGLLPVLLKLLLLLLLALLFEVLLDELLLPAAVLLALPLVARPLLRAIV 709

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2059325136 718 VVVDQAVEVQTLFDEMKQALADDACRFVQKVVLFDEFRAKSNTSGGLAAHEKSLAFRVTLQD 779
Cdd:COG0073   710 VDVAAAVAAALAAVAAALALVVALLAVVLLVVVVDVGVGKVLKKLLLSLDLEVTLLDLEELE 771
B3_4 pfam03483
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 218-391 3.87e-82

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 427327 [Multi-domain]  Cd Length: 174  Bit Score: 260.17  E-value: 3.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 218 LCGRFSGRVIRGVNARAKTPQWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLN 297
Cdd:pfam03483   1 ACPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 298 GNTVELDETVGVIADDRQVESLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVE 377
Cdd:pfam03483  81 GKERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEA 160

                         170
                  ....*....|....
gi 2059325136 378 HVERITQLILEICG 391
Cdd:pfam03483 161 ALDRATALLLELCG 174
tRNA_synthFbeta pfam17759
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic ...
 478-691 1.67e-70

Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic like domain (CLM) in the beta chain of phe tRNA synthetase.


Pssm-ID: 465487 [Multi-domain]  Cd Length: 214  Bit Score: 230.52  E-value: 1.67e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 478 IPARPPVATSEMRATNETRRSIHDIRHALAARDYAETVNFSFVDAEWERDFAGND---NPIRLLNPIASQLSVMRTTLFG 554
Cdd:pfam17759   1 IPSTLPKGPTTGGGLTPEQKLRRRVRDLLAAAGFTEVITYSFTSPKDLDKLLEDDprrKAVKLANPLSEELSVMRTSLLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 555 SLIAVLRHNLNRRADRVRVFETGRVFIADPSVkageltvEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGDLEA- 633
Cdd:pfam17759  81 GLLETLAYNLNRGNPDVRLFEIGRVFLPDELE-------ELPREPRRLAGLLTGKRLPESWQGKARPVDFYDLKGIVEAl 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 634 --LLAPAAARFVKAEHPALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEID 691
Cdd:pfam17759 154 laALGIDDYEFEAADHPALHPGRSAEILVGGKVIGFIGELHPEVAKNFDLPQPVYVFELD 213
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 219-391 5.23e-68

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 222.52  E-value: 5.23e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  219 CGRFSGRVIRGVNARAKTPQWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGG-IEVRWGKRGESLKLLN 297
Cdd:smart00873   1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  298 GNTVELDETVGVIADDRQVESLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVE 377
Cdd:smart00873  81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160

                          170
                   ....*....|....
gi 2059325136  378 HVERITQLILEICG 391
Cdd:smart00873 161 ALDRAAALLLEICG 174
PheRS_beta_core cd00769
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ...
 502-695 2.59e-60

Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.


Pssm-ID: 238392 [Multi-domain]  Cd Length: 198  Bit Score: 202.49  E-value: 2.59e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 502 IRHALAARDYAETVNFSFVDAEWERDFA-GNDNPIRLLNPIASQLSVMRTTLFGSLIAVLRHNLNRRADRVRVFETGRVF 580
Cdd:cd00769     9 LRRLLAGLGFQEVITYSLTSPEEAELFDgGLDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLRLFEIGRVF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 581 IADPsvkageltvEGYAQPKRVGALAYGPAFDEQWGIATRAVDFFDVKGDLEA--LLAPAAARFVKAEHPA--LHPGRSA 656
Cdd:cd00769    89 LKDE---------DGPEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEAllRALGIIVEFELEELDAdlFHPGRSA 159

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2059325136 657 RIEVDGRAVGWIGELHPRLMQKYELPHAPVMFEIDADAL 695
Cdd:cd00769   160 KIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
tRNA_bind_bactPheRS cd02796
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ...
 45-153 5.12e-52

tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.


Pssm-ID: 239196 [Multi-domain]  Cd Length: 103  Bit Score: 176.16  E-value: 5.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  45 IVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCGAPNVAPGIKVPVALVGAELPpaeeGGkpFAIKLSKLRGVESQGM 124
Cdd:cd02796     1 VVVGKVLEVEPHPNADKLNVCKVDIGENKPLQIVCGAPNVRAGDKVVVALPGAVLP----GG--LKIKKRKLRGVESEGM 74

                          90       100
                  ....*....|....*....|....*....
gi 2059325136 125 LCSARELKLSEDHSGLLILPEDTPVGQDI 153
Cdd:cd02796    75 LCSAKELGLGEDSDGIIELPEDAPVGTDI 103
syfB CHL00192
phenylalanyl-tRNA synthetase beta chain; Provisional
 160-796 7.95e-50

phenylalanyl-tRNA synthetase beta chain; Provisional


Pssm-ID: 214391 [Multi-domain]  Cd Length: 704  Bit Score: 187.22  E-value: 7.95e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 160 DDTIFEIKLTPNKADCLSVFGIARETAAITGApltpveirpAPVELD------------ETLPVRISAPDLCGRFSGRVI 227
Cdd:CHL00192   45 SDIILDISSTANRSDVLSIQGLSREISALFNS---------DPIKLKyynpsiswfdklKNLISNDSSKLNCSMFIAVII 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 228 RGVNARaKTPQWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHG-----GIEVRWGKRGESLK--LLNGNT 300
Cdd:CHL00192  116 ENIEIK-DSPKWLQNRLSSSGFKSLNNLTDIQNYIMLETGQPIEIYDLDKIYSknttsSLALSSKFALQKSSfiASNSKN 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 301 VELDETVGVIADDRQVESLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYATTVE-HV 379
Cdd:CHL00192  195 IELENNILVVQANNVIISIAGIISNEEIICDKNTKSILIEASIFDAAVIRKSSRKLGLRTDRSIRYEKSLKNDNLLEaYY 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 380 ERITQLILEICGGKAG------PVDDQAVNLpqrtpvKMRVSRANRIIG--------VQIDADEIANIFTRLGLPFERDG 445
Cdd:CHL00192  275 RLVSLLRILNPKLKCKfhfiykKIKNSSRRI------KLSYKKIKDILGpikintntRYLSPKEITNALKRLNFKITYDS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 446 D--VFSVTPPSHR-FDIEIEEDLIEEVARIYGFEKIPARPPVATSEMRAtNETRRSIHDIRHALAARDYAETVNFSFVDA 522
Cdd:CHL00192  349 LklNWEVLIPSYRkDDIVREIDVIEEIARIYGFNNFLSKLPNIKFIGRL-DIDYNTRDKIRSYLRNLGLTELIHYSLVKQ 427

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 523 EWErdfagNDNPIRLLNPIASQLSVMRTTLFGSLIAVLRHNLNRRADRVRVFETGRVFIADPSVKAGELTVegyaqpkrV 602
Cdd:CHL00192  428 ESF-----SKNEIKLKNPLIKDYSTLRSSLLPGLIEAVQENLKQGNSTLEGFEIGHVFNLDSSSIIEETEL--------A 494

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 603 GALAYGPAFDEQWGIATRAVDFFDVKGDLEALLAPAAARFVKAEHPAL------HPGRSARIEV-DGRAVGWIGELHPRL 675
Cdd:CHL00192  495 GGIFGGIDIRSSWSEKAQSLNWFEAKGIIENFFQKLNLPIYWKKYSDLdekinfHPYCTSEIFLsNGQKIGIFGQLHPLL 574

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 676 MQKYELPHAPVMFEIDADALIA----RALPALTDVSKFPPVRRDIAVVVDQAVEvqtlFDEMKQALADDACRFVQKVVLF 751
Cdd:CHL00192  575 ANKLNLNTEIYLFEINLDILQYsiqqNNLISYQPYSSYPKIIRDLSFIIKKSIS----ISKIKELIYQNGDNLLESITLF 650

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 2059325136 752 DEFRAKSntsggLAAHEKSLAFRVTLQDPAGTLQDEVVDQAIQTL 796
Cdd:CHL00192  651 DYYKGKS-----IPNGHTSLGLRLTFQSENKTLTNEEIDRIQQNL 690
tRNA_bindingDomain cd02153
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in ...
 45-153 8.88e-36

The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-tRNA synthetase(hTyrRS), Saccharomyces cerevisiae Arc1p, Thermus thermophilus CsaA, Aquifex aeolicus Trbp111, human p43 and human EMAP-II. PheRS, MetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. The molecular chaperones Trbp111 and CsaA also contain this domain. CsaA has export related activities; Trbp111 is structure-specific recognizing the L-shape of the tRNA fold. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. An EMAP-II-like cytokine is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain. For homodimeric members of this group which include CsaA, Trbp111 and Escherichia coli MetRS this domain acts as a dimerization domain.


Pssm-ID: 239066 [Multi-domain]  Cd Length: 99  Bit Score: 130.33  E-value: 8.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  45 IVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCGAPNVAP-----GIKVPVALVgaelppaeeggkpfaIKLSKLRGV 119
Cdd:cd02153     1 LRVGKIVEAEPHPNADKLYVLKVDIGEEKPRQIVSGAANVYPpeelvGKKVVVAVN---------------LKPKKLRGV 65

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2059325136 120 ESQGMLCSARELKLSEDHSGLLILPEDTPVGQDI 153
Cdd:cd02153    66 ESEGMLLSAEELGLEEGSVGILELPEDAPVGDRI 99
tRNA_bind pfam01588
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ...
 45-152 2.16e-26

Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.


Pssm-ID: 396251 [Multi-domain]  Cd Length: 96  Bit Score: 103.48  E-value: 2.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  45 IVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCGAPNVAPGIKvPVALVGAELPpaeeggkpfAIKLSKLRGVESQGM 124
Cdd:pfam01588   1 LRVGKVVEAERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEE-LVGRLVVVVA---------NLKPAKLRGVESEGM 70

                          90       100
                  ....*....|....*....|....*...
gi 2059325136 125 LCSARElkLSEDHSGLLILPEDTPVGQD 152
Cdd:pfam01588  71 ILSAEE--LDGGSVGLLEPPADVPPGTK 96
FDX-ACB smart00896
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ...
 707-808 3.81e-26

Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2).


Pssm-ID: 214893 [Multi-domain]  Cd Length: 93  Bit Score: 102.89  E-value: 3.81e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  707 SKFPPVRRDIAVVVDQAVEVQTLFDEMKQALADdacrFVQKVVLFDEFRaksntsGGLAAHEKSLAFRVTLQDPAGTLQD 786
Cdd:smart00896   1 SKFPAVRRDLAFVVDEDVPAAELLDAIREAGGD----LLEDVRLFDVYE------GGIPEGKKSLAYRLTYQSPDRTLTD 70

                           90       100
                   ....*....|....*....|...
gi 2059325136  787 EVVDQAIQTLVERMARA-GARLR 808
Cdd:smart00896  71 EEVNAIHDKIVAALEKKfGAELR 93
FDX-ACB pfam03147
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ...
 707-808 8.82e-23

Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold.


Pssm-ID: 460826 [Multi-domain]  Cd Length: 94  Bit Score: 93.31  E-value: 8.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 707 SKFPPVRRDIAVVVDQAVEVQTLFDEMKQAladdACRFVQKVVLFDEFRAKsntsgGLAAHEKSLAFRVTLQDPAGTLQD 786
Cdd:pfam03147   1 SKYPAVRRDLAFVVDEDVPAADILKAIREA----GGELLESVELFDVYRGE-----KIPEGKKSLAFRLTFQSPERTLTD 71

                          90       100
                  ....*....|....*....|...
gi 2059325136 787 EVVDQAIQTLVERMA-RAGARLR 808
Cdd:pfam03147  72 EEVNAIIEKIVEALEkKFGAELR 94
PLN02265 PLN02265
probable phenylalanyl-tRNA synthetase beta chain
 309-696 2.90e-20

probable phenylalanyl-tRNA synthetase beta chain


Pssm-ID: 215149 [Multi-domain]  Cd Length: 597  Bit Score: 95.52  E-value: 2.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 309 VIAD-DRQVESLAGIMGGDSTAVTLDTTNIYLE--AAFWWPDSIRGRARKYNFSTDAAHRFErgvdyattVEHVERITql 385
Cdd:PLN02265  227 VIYDsNRTVLSLPPIINGAHSAITLDTKNVFIEctATDLTKAKIVLNTMVTMFSEYCARKFE--------VEPVEVVY-- 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 386 ileicggkagpVDDQAVNLPQRTPVKMRVSRA--NRIIGVQIDADEIANIFTRLGLPFER---DGDVFSVTPPSHRFDIE 460
Cdd:PLN02265  297 -----------PDGKSTVYPDLSVRTMEVDLSyiNSSIGVSLDAEEVASLLNKMQLQAEQssdDGCTIRVSVPPTRSDIL 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 461 IEEDLIEEVARIYGFEKIPAR-PPVATSEMRAT-NETRrsihD-IRHALAARDYAETV---------NFSFVDaeweRDF 528
Cdd:PLN02265  366 HPCDVAEDVAIAYGYNNIPKRkPKSMTVGKQQPlNQFS----DlLRAEVAMAGFTEVLtwilcshkeNFAMLN----RED 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 529 AGNDNPIrLLNPIASQLSVMRTTLFGSLIAVLRHNlnRRADR-VRVFETGRVFIADPSvkagelTVEGYAQPKRVGALAY 607
Cdd:PLN02265  438 DGNSAVI-IGNPRSADFEVVRTSLLPGLLKTLGHN--KDAPKpIKLFEVSDVVLLDES------KDVGARNSRRLAALYC 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 608 GP--AFDEQWGIATRavdFFDVKGDLEALLAPAAARFVKAEH-PALHPGRSARIEVDGRAVGWIGELHPRLMQKYELPHA 684
Cdd:PLN02265  509 GTtsGFEVIHGLVDR---IMEVLGIPFVEIGDNNGYYVEPSNePEYFPGRQASIIYKGKHVGTFGIVHPEVLNNFDIPDP 585

                         410
                  ....*....|..
gi 2059325136 685 PVMFEIDADALI 696
Cdd:PLN02265  586 CSFLELDLEPLL 597
B5 smart00874
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
 408-475 6.34e-14

tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.


Pssm-ID: 197942 [Multi-domain]  Cd Length: 68  Bit Score: 67.13  E-value: 6.34e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2059325136  408 TPVKMRVSRANRIIGVQIDADEIANIFTRLGLPFERDGDVFSVTPPSHRFDIEIEEDLIEEVARIYGF 475
Cdd:smart00874   1 RTITLRLERINRLLGLEILAEEIEEILKRLGFEVEVSGDTLEVTVPSYRFDILIEADLIEEVARIYGY 68
tRNA_bind_EMAP-II_like cd02799
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of ...
 45-153 6.77e-14

tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.


Pssm-ID: 239198 [Multi-domain]  Cd Length: 105  Bit Score: 68.41  E-value: 6.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  45 IVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCGAPNVAP-----GIKVpvaLVGAELPPAeeggkpfaiklsKLRGV 119
Cdd:cd02799     8 IRVGKILKVRKHPDADSLYVEEIDLGEEEPRTIVSGLVKFVPleqmqNRLV---VVLCNLKPR------------KMRGV 72

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2059325136 120 ESQGM-LCSArelklSEDHSG--LLILPEDTPVGQDI 153
Cdd:cd02799    73 KSQGMvLCAS-----NADHEKveLLEPPEGAKPGERV 104
B5 pfam03484
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
 410-475 2.92e-12

tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.


Pssm-ID: 460942 [Multi-domain]  Cd Length: 67  Bit Score: 62.41  E-value: 2.92e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2059325136 410 VKMRVSRANRIIGVQIDADEIANIFTRLGLPF-ERDGDVFSVTPPSHRFdieieedlieeVARIYGF 475
Cdd:pfam03484   1 ITLRLDRINRLLGIDLSAEEIVEILERLGFEVeEEDGDTLTVTVPSYRPdilheadlieeVARIYGY 67
PLN02610 PLN02610
probable methionyl-tRNA synthetase
 45-187 1.71e-08

probable methionyl-tRNA synthetase


Pssm-ID: 215329 [Multi-domain]  Cd Length: 801  Bit Score: 58.25  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  45 IVVGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCGAPNVAP-----GIKVPVAlvgAELPPAeeggkpfaiklsKLRGV 119
Cdd:PLN02610  645 IRVGLIVKAEKHPDADSLYVEEIDVGEGAPRTVVSGLVKYIPleemqNRKVCVL---CNLKPA------------AMRGI 709

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 120 ESQGMLCSARelklSEDHSGLLIL--PEDTPVGQDIR---------DALNLDDTIFEiKLTPN---KADCLSVF-GIARE 184
Cdd:PLN02610  710 KSQAMVLAAS----NSDHTKVELVepPESAAVGERVTfpgfegepdDVLNPKKKVWE-TLQPDlhtNSELVACYkDVPFT 784


                  ...
gi 2059325136 185 TAA 187
Cdd:PLN02610  785 TSA 787
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
 47-154 1.75e-08

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 57.89  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  47 VGRVLEVVKHPDADKLNVCQVDAGAGATLNIVCgapnvapGIK---VPVALVG------AELPPAeeggkpfaiklsKLR 117
Cdd:PRK12267  555 VAEVLEAEKVEKSDKLLKLQVDLGEEEPRQIVS-------GIAkfyPPEELVGkkvvvvANLKPA------------KLM 615

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2059325136 118 GVESQGMLCSARElklsEDHSGLLILPEDTPVGQDIR 154
Cdd:PRK12267  616 GEESQGMILAAED----DGKLTLLTVDKEVPNGSKVK 648
B3/B4 COG3382
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ...
 251-339 2.71e-06

B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];


Pssm-ID: 442609 [Multi-domain]  Cd Length: 233  Bit Score: 49.47  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136 251 SVSALVDISNYVMFELGRPSHVFDLDKIHGGIEVRWGKRGESLKLLNGNTVE-LDETVGVIADDrqveslAGIMG----- 324
Cdd:COG3382    97 RINPLVDLYNAVSLRYLLPIGGYDLDKIEGDLRLRLARGGESFLPIGGDEEEpPEPGEVVYADD------EGVFCrrwpw 170

                          90
                  ....*....|....*..
gi 2059325136 325 --GDSTAVTLDTTNIYL 339
Cdd:COG3382   171 rdSERTKVTEETKNALF 187
tRNA_bind_EcMetRS_like cd02800
tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like ...
 45-154 2.27e-05

tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine transfer RNAs (tRNAmet). AaTrbp111 is structure-specific molecular chaperone recognizing the L-shape of the tRNA fold. AaTrbp111 plays a role in nuclear trafficking of tRNAs. The functional unit of EcMetRs and AaTrbp111 is a homodimer, this domain acts as the dimerization domain.


Pssm-ID: 239199 [Multi-domain]  Cd Length: 105  Bit Score: 44.03  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  45 IVVGRVLEVVKHPDADKLNVCQVDAGaGATLNIVCG-----APNVAPGIKVpvaLVGAELPPAeeggkpfaiklsKLRGV 119
Cdd:cd02800    11 LRVGKVLEAERVEGSDKLLKLTVDLG-EEERQIVSGiakfyPPEELVGKKV---VVVANLKPR------------KLRGV 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2059325136 120 ESQGMLCSAR-ELKLSedhsgLLILPEDTPVGQDIR 154
Cdd:cd02800    75 ESQGMILAAEdGGKLK-----LLTPDEEVEPGSRVS 105
metG PRK00133
methionyl-tRNA synthetase; Reviewed
 47-139 1.64e-03

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 42.06  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059325136  47 VGRVLEVVKHPDADKLNVCQVDAGaGATLNIVCgapnvapGIKV---PVALVG------AELPPAeeggkpfaiklsKLR 117
Cdd:PRK00133  580 VAKIVEAEKVEGADKLLKLTLDLG-EETRQVFS-------GIKSaydPEELVGklvvmvANLAPR------------KMK 639

                          90       100
                  ....*....|....*....|....*.
gi 2059325136 118 GVESQGMLCSA----RELKLSEDHSG 139
Cdd:PRK00133  640 FGVSEGMVLAAgpggGDLFLLEPDEG 665
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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