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Conserved domains on  [gi|2062740989|ref|WP_217487369|]
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5-carboxymethyl-2-hydroxymuconate Delta-isomerase, partial [Acinetobacter oleivorans]

Protein Classification

5-carboxymethyl-2-hydroxymuconate Delta-isomerase( domain architecture ID 10790028)

5-carboxymethyl-2-hydroxymuconate Delta-isomerase transforms 5-carboxymethyl-2-hydroxy-muconic acid (CHM) into 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid (OPET) in the homoprotocatechuate pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HpaF COG3232
5-carboxymethyl-2-hydroxymuconate isomerase [Amino acid transport and metabolism];
2-94 3.73e-31

5-carboxymethyl-2-hydroxymuconate isomerase [Amino acid transport and metabolism];


:

Pssm-ID: 442464 [Multi-domain]  Cd Length: 121  Bit Score: 105.71  E-value: 3.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   2 TLIETELFSPEDIKSRARKDEVFLIGLG-ADQAYIHVKVYILSGRTAEQKQLIGDQLLTALsnKNYLQQEFNKEIQLCVE 80
Cdd:COG3232    27 ALAASGLFPLGDIKVRAIPLDHYLVGDGgPDDAFVHVTLRILAGRSDEQKQALSEALFAAL--RAHLAPVFARYVALSVE 104

                          90
                  ....*....|....
gi 2062740989  81 LVDMPREDYFKQVV 94
Cdd:COG3232   105 IREIDRASYAKRNN 118
 
Name Accession Description Interval E-value
HpaF COG3232
5-carboxymethyl-2-hydroxymuconate isomerase [Amino acid transport and metabolism];
2-94 3.73e-31

5-carboxymethyl-2-hydroxymuconate isomerase [Amino acid transport and metabolism];


Pssm-ID: 442464 [Multi-domain]  Cd Length: 121  Bit Score: 105.71  E-value: 3.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   2 TLIETELFSPEDIKSRARKDEVFLIGLG-ADQAYIHVKVYILSGRTAEQKQLIGDQLLTALsnKNYLQQEFNKEIQLCVE 80
Cdd:COG3232    27 ALAASGLFPLGDIKVRAIPLDHYLVGDGgPDDAFVHVTLRILAGRSDEQKQALSEALFAAL--RAHLAPVFARYVALSVE 104

                          90
                  ....*....|....
gi 2062740989  81 LVDMPREDYFKQVV 94
Cdd:COG3232   105 IREIDRASYAKRNN 118
CHMI cd00580
5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the ...
 2-87 3.50e-25

5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the homoprotocatechuate pathway, one of the microbial meta-fission pathways that degrade aromatic carbon sources to citric acid cycle intermediates. Despite the structural similarity of CHMI with 4-oxalocrotonate tautomerase (4-OT) and macrophage migration inhibitory factor (MIF), there is no significant sequence similarity among these protein families, and therefore, they are not combined in one hierarchy.


Pssm-ID: 238324 [Multi-domain]  Cd Length: 113  Bit Score: 90.32  E-value: 3.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   2 TLIETELFSPEDIKSRARKDEVFLIGLGA-DQAYIHVKVYILSGRTAEQKQLIGDQLLTALsnKNYLQQEFNKE-IQLCV 79
Cdd:cd00580    27 ALVASGLFPLGGIKVRAIRADHYRVGDGDeDDAFIHVTLRILAGRSEEQKQELSEALLAAL--RAHLAPVFAKRyLSLSV 104


                  ....*...
gi 2062740989  80 ELVDMPRE 87
Cdd:cd00580   105 EIRELDPA 112
CHMI pfam02962
5-carboxymethyl-2-hydroxymuconate isomerase;
2-92 6.61e-08

5-carboxymethyl-2-hydroxymuconate isomerase;


Pssm-ID: 427080  Cd Length: 124  Bit Score: 46.33  E-value: 6.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   2 TLIETELFSPEDIKSRARKDEVFLIGLG-ADQAYIHVKVYILSGRTAEQKQLIGDQLLTALsnKNYLQQEFNKE-IQLCV 79
Cdd:pfam02962  27 VLIATGVFPLGGIRVRAIRLDHYAVADGlPDDAFVHLTLKIGAGRSEEVKKAAGDALFAAI--KDHFAPLFARRyLALSL 104

                          90
                  ....*....|...
gi 2062740989  80 ELVDMPREDYFKQ 92
Cdd:pfam02962 105 EIREFDEALSWKH 117
PRK15031 PRK15031
5-carboxymethyl-2-hydroxymuconate Delta-isomerase;
1-74 1.76e-03

5-carboxymethyl-2-hydroxymuconate Delta-isomerase;


Pssm-ID: 184991  Cd Length: 126  Bit Score: 34.84  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   1 TTLIETELFSPEDIKSRARKDEVFLIGLGA-DQAYIHVKVYILSGRTAEQKQLIGDQLLT-------ALSNKNYLQQEFN 72
Cdd:PRK15031   27 QALAATGIFPLGGIRSRAHWLDTWQMADGKhDYAFVHMTLKIGAGRSLESRQEVGEMLFAlikahfaALMESRYLALSFE 106


                  ..
gi 2062740989  73 KE 74
Cdd:PRK15031  107 IE 108
 
Name Accession Description Interval E-value
HpaF COG3232
5-carboxymethyl-2-hydroxymuconate isomerase [Amino acid transport and metabolism];
2-94 3.73e-31

5-carboxymethyl-2-hydroxymuconate isomerase [Amino acid transport and metabolism];


Pssm-ID: 442464 [Multi-domain]  Cd Length: 121  Bit Score: 105.71  E-value: 3.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   2 TLIETELFSPEDIKSRARKDEVFLIGLG-ADQAYIHVKVYILSGRTAEQKQLIGDQLLTALsnKNYLQQEFNKEIQLCVE 80
Cdd:COG3232    27 ALAASGLFPLGDIKVRAIPLDHYLVGDGgPDDAFVHVTLRILAGRSDEQKQALSEALFAAL--RAHLAPVFARYVALSVE 104

                          90
                  ....*....|....
gi 2062740989  81 LVDMPREDYFKQVV 94
Cdd:COG3232   105 IREIDRASYAKRNN 118
CHMI cd00580
5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the ...
 2-87 3.50e-25

5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the homoprotocatechuate pathway, one of the microbial meta-fission pathways that degrade aromatic carbon sources to citric acid cycle intermediates. Despite the structural similarity of CHMI with 4-oxalocrotonate tautomerase (4-OT) and macrophage migration inhibitory factor (MIF), there is no significant sequence similarity among these protein families, and therefore, they are not combined in one hierarchy.


Pssm-ID: 238324 [Multi-domain]  Cd Length: 113  Bit Score: 90.32  E-value: 3.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   2 TLIETELFSPEDIKSRARKDEVFLIGLGA-DQAYIHVKVYILSGRTAEQKQLIGDQLLTALsnKNYLQQEFNKE-IQLCV 79
Cdd:cd00580    27 ALVASGLFPLGGIKVRAIRADHYRVGDGDeDDAFIHVTLRILAGRSEEQKQELSEALLAAL--RAHLAPVFAKRyLSLSV 104


                  ....*...
gi 2062740989  80 ELVDMPRE 87
Cdd:cd00580   105 EIRELDPA 112
CHMI pfam02962
5-carboxymethyl-2-hydroxymuconate isomerase;
2-92 6.61e-08

5-carboxymethyl-2-hydroxymuconate isomerase;


Pssm-ID: 427080  Cd Length: 124  Bit Score: 46.33  E-value: 6.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   2 TLIETELFSPEDIKSRARKDEVFLIGLG-ADQAYIHVKVYILSGRTAEQKQLIGDQLLTALsnKNYLQQEFNKE-IQLCV 79
Cdd:pfam02962  27 VLIATGVFPLGGIRVRAIRLDHYAVADGlPDDAFVHLTLKIGAGRSEEVKKAAGDALFAAI--KDHFAPLFARRyLALSL 104

                          90
                  ....*....|...
gi 2062740989  80 ELVDMPREDYFKQ 92
Cdd:pfam02962 105 EIREFDEALSWKH 117
PRK15031 PRK15031
5-carboxymethyl-2-hydroxymuconate Delta-isomerase;
1-74 1.76e-03

5-carboxymethyl-2-hydroxymuconate Delta-isomerase;


Pssm-ID: 184991  Cd Length: 126  Bit Score: 34.84  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062740989   1 TTLIETELFSPEDIKSRARKDEVFLIGLGA-DQAYIHVKVYILSGRTAEQKQLIGDQLLT-------ALSNKNYLQQEFN 72
Cdd:PRK15031   27 QALAATGIFPLGGIRSRAHWLDTWQMADGKhDYAFVHMTLKIGAGRSLESRQEVGEMLFAlikahfaALMESRYLALSFE 106


                  ..
gi 2062740989  73 KE 74
Cdd:PRK15031  107 IE 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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