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Conserved domains on  [gi|2067439411|ref|WP_218149768|]
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TetR/AcrR family transcriptional regulator [Variovorax sp. OV084]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
11-165 7.55e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.46  E-value: 7.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067439411  11 ERRAELGEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLIICSVKQYKARCVTRYDHAVESATTYDELmEG 90
Cdd:COG1309     6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERL-RA 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067439411  91 FLQSLGDTLCDEGHVHRLWYdlrSQALFEEAFRADVVQIDKSLEDMIWRIMSRFAELSGETPGMPPSATYALFDG 165
Cdd:COG1309    85 LLRAYLEFLAENPALARLLL---AEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
11-165 7.55e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.46  E-value: 7.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067439411  11 ERRAELGEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLIICSVKQYKARCVTRYDHAVESATTYDELmEG 90
Cdd:COG1309     6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERL-RA 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067439411  91 FLQSLGDTLCDEGHVHRLWYdlrSQALFEEAFRADVVQIDKSLEDMIWRIMSRFAELSGETPGMPPSATYALFDG 165
Cdd:COG1309    85 LLRAYLEFLAENPALARLLL---AEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-59 7.79e-05

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 38.93  E-value: 7.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2067439411  18 EAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLI 59
Cdd:pfam00440   3 DAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK00767 PRK00767
transcriptional regulator BetI; Validated
12-60 9.56e-04

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 38.67  E-value: 9.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2067439411  12 RRAELGEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLII 60
Cdd:PRK00767   10 RRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLE 58
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
12-58 4.29e-03

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 36.80  E-value: 4.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2067439411  12 RRAELgEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDL 58
Cdd:NF041196    8 RRAIL-EAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAL 53
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
11-165 7.55e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.46  E-value: 7.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067439411  11 ERRAELGEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLIICSVKQYKARCVTRYDHAVESATTYDELmEG 90
Cdd:COG1309     6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERL-RA 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067439411  91 FLQSLGDTLCDEGHVHRLWYdlrSQALFEEAFRADVVQIDKSLEDMIWRIMSRFAELSGETPGMPPSATYALFDG 165
Cdd:COG1309    85 LLRAYLEFLAENPALARLLL---AEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
11-196 7.93e-14

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 66.89  E-value: 7.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067439411  11 ERRAELGEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLIICSVKQYKARCVTRYDHAVESATTYDELMEG 90
Cdd:COG3226     8 ERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067439411  91 FLQSLGDTLCDEGHVHRLWYDLRSQALFEEAFRADVVQIDKSLEDMIWRImsrFAELSGETPGMPPSATYALFDGLFQQA 170
Cdd:COG3226    88 LADLLAELLPADRDRLLARYELYLEALRDPELRALLRRWRDRLREALARL---LAALGSPDPPETARALVALIDGLTLHA 164
                         170       180
                  ....*....|....*....|....*.
gi 2067439411 171 LLKHLSGDAkaidnmqADVRQAISRL 196
Cdd:COG3226   165 LLDPDPLTR-------EELRAALRRL 183
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-59 7.79e-05

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 38.93  E-value: 7.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2067439411  18 EAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLI 59
Cdd:pfam00440   3 DAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK00767 PRK00767
transcriptional regulator BetI; Validated
12-60 9.56e-04

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 38.67  E-value: 9.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2067439411  12 RRAELGEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDLII 60
Cdd:PRK00767   10 RRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLE 58
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
12-58 4.29e-03

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 36.80  E-value: 4.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2067439411  12 RRAELgEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDL 58
Cdd:NF041196    8 RRAIL-EAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAL 53
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
3-58 5.84e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 36.64  E-value: 5.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2067439411   3 KTRVDKFSERRaELGEAALTTLAALGYARTSLREIAQNSEFSHGVLHYYFSDKVDL 58
Cdd:PRK09975    4 KTKAEALKTRQ-ELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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