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Conserved domains on  [gi|2072564767|ref|WP_218964336|]
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sensor histidine kinase [Bacillus sp. AFS031507]

Protein Classification

sensor histidine kinase( domain architecture ID 11459466)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to a signal; may contain an N-terminal HAMP signaling domain

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
155-602 4.99e-96

Sensor histidine kinase YesM [Signal transduction mechanisms];


:

Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 301.55  E-value: 4.99e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 155 EEYWYSSVPLNGMSMLVMRKLKLENKEQPVISLVRRLYNPQTLLPVGMLIIDINFRRIEEISNKVTISKNGYFSILDANG 234
Cdd:COG2972     7 LLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 235 HYIYHPDYLKLGKRVEFKQLSNLKTEGSSTEILENERRDFVTYTFSRNLGWRFLSAVPYRDLTGGIVQIEKAISLTILVS 314
Cdd:COG2972    87 LLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 315 LIIAYLIGFGFATSIIRPIRRLQHFMKEVEIGKLdGRVRVDSNDEIGQLTAGFNNTVEKLSNLLEEVYvsklkeaEMSLK 394
Cdd:COG2972   167 LLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVY-------ELELE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 395 QKEVELKMLQSQMNPHFLYNSLETIRGMALEENQENIATMSFSLGKLLRYNLNNHSSTVSFREEVNFCEMYLQIQKFRFE 474
Cdd:COG2972   239 KKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 475 DRFEYMFDIPQWVMELEMVKFSLQPLVENCFVHGFGPNTRKLKIVISAFRhSESSVVIRISDTGEGIKDHILEEIKKRMD 554
Cdd:COG2972   319 DRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRK-EGDRLVITVEDNGVGMPEEKLEKLLEELS 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2072564767 555 LKtatSDGKNIGIVNVHQRIHYLFGPEYGITIQSEQGSGTEVLIHLPI 602
Cdd:COG2972   398 SK---GEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPL 442
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
155-602 4.99e-96

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 301.55  E-value: 4.99e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 155 EEYWYSSVPLNGMSMLVMRKLKLENKEQPVISLVRRLYNPQTLLPVGMLIIDINFRRIEEISNKVTISKNGYFSILDANG 234
Cdd:COG2972     7 LLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 235 HYIYHPDYLKLGKRVEFKQLSNLKTEGSSTEILENERRDFVTYTFSRNLGWRFLSAVPYRDLTGGIVQIEKAISLTILVS 314
Cdd:COG2972    87 LLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 315 LIIAYLIGFGFATSIIRPIRRLQHFMKEVEIGKLdGRVRVDSNDEIGQLTAGFNNTVEKLSNLLEEVYvsklkeaEMSLK 394
Cdd:COG2972   167 LLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVY-------ELELE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 395 QKEVELKMLQSQMNPHFLYNSLETIRGMALEENQENIATMSFSLGKLLRYNLNNHSSTVSFREEVNFCEMYLQIQKFRFE 474
Cdd:COG2972   239 KKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 475 DRFEYMFDIPQWVMELEMVKFSLQPLVENCFVHGFGPNTRKLKIVISAFRhSESSVVIRISDTGEGIKDHILEEIKKRMD 554
Cdd:COG2972   319 DRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRK-EGDRLVITVEDNGVGMPEEKLEKLLEELS 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2072564767 555 LKtatSDGKNIGIVNVHQRIHYLFGPEYGITIQSEQGSGTEVLIHLPI 602
Cdd:COG2972   398 SK---GEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPL 442
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 399-477 4.89e-30

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 112.92  E-value: 4.89e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2072564767 399 ELKMLQSQMNPHFLYNSLETIRGMAlEENQENIATMSFSLGKLLRYNLNNHSSTVSFREEVNFCEMYLQIQKFRFEDRF 477
Cdd:pfam06580   2 ELKALQAQINPHFLFNTLNSISSLA-IEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 494-601 4.93e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 96.75  E-value: 4.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 494 KFSLQPLVENCFVHGFGPNTRKLKIVISAfRHSESSVVIRISDTGEGIKDHILEEIKKRMDlktatsDGKNIGIVNVHQR 573
Cdd:cd16924     3 PFTLQPLVENAIQHGLSPLTDKGVVTISA-LKEDNHVMIEVEDNGRGIDPKVLNILGKKPK------EGNGIGLYNVHQR 75

                          90       100
                  ....*....|....*....|....*...
gi 2072564767 574 IHYLFGPEYGITIQSEQGSGTEVLIHLP 601
Cdd:cd16924    76 LILLFGEDYGIHIASEPDKGTRITFTIP 103
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
328-379 1.78e-09

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 53.79  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2072564767  328 SIIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGFNNTVEKLSNLLE 379
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 513-610 1.64e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 48.01  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 513 TRKLKIVISAFRHSESSVVIRISDTGEGIKDHILEEI-------KKRMDLKTATsdGKNIGIVnVHQRIHYLFGPEygIT 585
Cdd:PRK11091  414 TQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIfamyyqvKDSHGGKPAT--GTGIGLA-VSKRLAQAMGGD--IT 488

                          90       100
                  ....*....|....*....|....*..
gi 2072564767 586 IQSEQGSGT--EVLIHLPILDHHVEEE 610
Cdd:PRK11091  489 VTSEEGKGScfTLTIHAPAVAEEVEDA 515
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
155-602 4.99e-96

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 301.55  E-value: 4.99e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 155 EEYWYSSVPLNGMSMLVMRKLKLENKEQPVISLVRRLYNPQTLLPVGMLIIDINFRRIEEISNKVTISKNGYFSILDANG 234
Cdd:COG2972     7 LLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 235 HYIYHPDYLKLGKRVEFKQLSNLKTEGSSTEILENERRDFVTYTFSRNLGWRFLSAVPYRDLTGGIVQIEKAISLTILVS 314
Cdd:COG2972    87 LLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 315 LIIAYLIGFGFATSIIRPIRRLQHFMKEVEIGKLdGRVRVDSNDEIGQLTAGFNNTVEKLSNLLEEVYvsklkeaEMSLK 394
Cdd:COG2972   167 LLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVY-------ELELE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 395 QKEVELKMLQSQMNPHFLYNSLETIRGMALEENQENIATMSFSLGKLLRYNLNNHSSTVSFREEVNFCEMYLQIQKFRFE 474
Cdd:COG2972   239 KKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 475 DRFEYMFDIPQWVMELEMVKFSLQPLVENCFVHGFGPNTRKLKIVISAFRhSESSVVIRISDTGEGIKDHILEEIKKRMD 554
Cdd:COG2972   319 DRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRK-EGDRLVITVEDNGVGMPEEKLEKLLEELS 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2072564767 555 LKtatSDGKNIGIVNVHQRIHYLFGPEYGITIQSEQGSGTEVLIHLPI 602
Cdd:COG2972   398 SK---GEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPL 442
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
274-602 6.33e-50

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 176.98  E-value: 6.33e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 274 FVTYTFSRNLGWRFLSAVPYRDLTGGIVQIEKAISLTILVSLIIAYLIGFGFATSIIRPIRRLQHFMKEVEIGKLDGRVR 353
Cdd:COG3275    35 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 354 VDSNDEIGQLTAGFNNTVEKLSNLLEEVYVSKLKEAEMSLKQKEVELKMLQSQMNPHFLYNSLETIRGMALEeNQENIAT 433
Cdd:COG3275   115 LLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIRE-DPEKARE 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 434 MSFSLGKLLRYNL-NNHSSTVSFREEVNFCEMYLQIQKFRFEDRFEYMFDIPQWVMELEMVKFSLQPLVENCFVHGFGPN 512
Cdd:COG3275   194 LLLKLSDLLRYSLyESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSK 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 513 TRKLKIVISaFRHSESSVVIRISDTGEGIKdhileeikkrmdlKTATSDGKNIGIVNVHQRIHYLFGPEYGITIQSEQGS 592
Cdd:COG3275   274 EGGGTISIS-IEVEGDRLVIEVENNGVGIQ-------------PKKKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGG 339

                         330
                  ....*....|
gi 2072564767 593 GTEVLIHLPI 602
Cdd:COG3275   340 GTKVTLKIPL 349
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 399-477 4.89e-30

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 112.92  E-value: 4.89e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2072564767 399 ELKMLQSQMNPHFLYNSLETIRGMAlEENQENIATMSFSLGKLLRYNLNNHSSTVSFREEVNFCEMYLQIQKFRFEDRF 477
Cdd:pfam06580   2 ELKALQAQINPHFLFNTLNSISSLA-IEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 494-601 4.93e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 96.75  E-value: 4.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 494 KFSLQPLVENCFVHGFGPNTRKLKIVISAfRHSESSVVIRISDTGEGIKDHILEEIKKRMDlktatsDGKNIGIVNVHQR 573
Cdd:cd16924     3 PFTLQPLVENAIQHGLSPLTDKGVVTISA-LKEDNHVMIEVEDNGRGIDPKVLNILGKKPK------EGNGIGLYNVHQR 75

                          90       100
                  ....*....|....*....|....*...
gi 2072564767 574 IHYLFGPEYGITIQSEQGSGTEVLIHLP 601
Cdd:cd16924    76 LILLFGEDYGIHIASEPDKGTRITFTIP 103
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 53-290 9.80e-16

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 76.99  E-value: 9.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767  53 ELENVLRQSSSQVIDQVETHIEYYLQDFEITSLKIINSPELSSLLKLKTSENRDQFIEPTRntlkeaeySRADITNITIL 132
Cdd:pfam02743   2 AIKEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLESLLR--------SNPGISSIYLV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 133 LNNNQVIDTLGNRNFYPAAKMKEEYWYSSVPLNGMSMLVM--RKLKLENKEQPVISLVRRLYNPQTLlPVGMLIIDINFR 210
Cdd:pfam02743  74 DADGRVLASSDESPSYPGLDVSERPWYKEALKGGGGIIWVfsSPYPSSESGEPVLTIARPIYDDDGE-VIGVLVADLDLD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 211 RIEEISNKVTISKNGYFSILDANGHYIYHPDYLKLGKRVEFKQLSNLKTEGSSTEILE-----NERRDFVTYTFSRNLGW 285
Cdd:pfam02743 153 TLQELLSQIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFLGKSLADALPGSGITEiavdlDGEDYLVAYAPIPGTGW 232


                  ....*
gi 2072564767 286 RFLSA 290
Cdd:pfam02743 233 TLVVV 237
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 495-601 2.72e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 69.00  E-value: 2.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 495 FSLQPLVENCFVHGFGPNTRKLKIVISAfRHSESSVVIRISDTGEGIKDHILEEIKKRmdlktaTSDGknIGIVNVHQRI 574
Cdd:cd16956     4 LTLQPIVENAVKHGLSGLLDGGRVEITA-RLDGQHLLLEVEDNGGGMDPDTLARILIR------SSNG--LGLNLVDKRL 74

                          90       100
                  ....*....|....*....|....*..
gi 2072564767 575 HYLFGPEYGITIQSEQGSGTEVLIHLP 601
Cdd:cd16956    75 RQAFGNDYGLDIECAPGEGTRITIRLP 101
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 494-601 2.83e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 69.03  E-value: 2.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 494 KFSLQPLVENCFVHGFGPNTRKLKIVISAFRHSESSVVIRISDTGEGIKDHILEEikkrmdLKTATSDGKNIGIVNVHQR 573
Cdd:cd16955     3 KLMIQPLVENAIVHGIQEKKGKGVVKISVKKQLKNRLHIAVEDNGIGISPKVIER------VEQDEMPGNKIGLLNVHQR 76

                          90       100
                  ....*....|....*....|....*...
gi 2072564767 574 IHYLFGpeYGITIQSEQGSGTEVLIHLP 601
Cdd:cd16955    77 LKLGYG--EGLHIRSRPDPGTLIAFYIP 102
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
184-612 1.95e-13

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 73.22  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 184 VISLVRRLYNPQTLLPVGMLIIDINFRRIEEISNKVTISKNGYFSILDANGHYIYHPDYLKLGKRVEFKQLSNLKTEGSS 263
Cdd:COG2770    91 LLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 264 TEILENERRDFVTYTFSRNLGWRFLSAVPYRDLTGGIVQIEKAISLTILVSLIIAYLIGFGFATSIIRPIRRLQHFMKEV 343
Cdd:COG2770   171 GELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRI 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 344 EIGKLDGRVRVDSNDEIGQLTAGFNNTVEKLSNLLEEVYVSKLKEAEMSLKQKEVELKMLQSQMNPHFLYNSLETIRGMA 423
Cdd:COG2770   251 AAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLL 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 424 LEENQENIATMSFSLGKLLRYNLNNHSSTVSFREEVNFCEMYLQIQKFRFEDRFEYmFDIPQWVMELEMVKFSLQPLVEN 503
Cdd:COG2770   331 ELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEA-ELAAVLALLAALAAALLLLELAL 409

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 504 CFVHGFGPNTRKLKIVISAFRHSESSVVIRISDTGEGIKDHILEEIKKRMDLKTATSDGKNIGIVNVHQRIHYLFGPEYG 583
Cdd:COG2770   410 EELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALEL 489

                         410       420
                  ....*....|....*....|....*....
gi 2072564767 584 ITIQSEQGSGTEVLIHLPILDHHVEEERV 612
Cdd:COG2770   490 LLLEEEEEAGAAAEELAEELLLLEGLLLL 518
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 495-601 2.80e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 63.21  E-value: 2.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 495 FSLQPLVENCFVHGFGPNTRKLKIVISAFRhSESSVVIRISDTGEGIKDHILEEIKKrmdlKTATSD-GKNIGIVNVHQR 573
Cdd:cd16957     4 FALQVLVENAIRHAFPKRKENNEVRVVVKK-DQHKVHVSVSDNGQGIPEERLDLLGK----TTVTSEkGTGTALENLNRR 78

                          90       100
                  ....*....|....*....|....*...
gi 2072564767 574 IHYLFGPEYGITIQSEQGSGTEVLIHLP 601
Cdd:cd16957    79 LIGLFGSEACLHIESEVHGGTEVWFVIP 106
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
300-381 7.33e-12

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 68.12  E-value: 7.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 300 IVQIEKAISLTILVSLIIAYLIGFGFATSIIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGFNNTVEKLSNLLE 379
Cdd:COG0840   177 AALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVG 256


                  ..
gi 2072564767 380 EV 381
Cdd:COG0840   257 QV 258
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 330-374 2.18e-11

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 59.00  E-value: 2.18e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2072564767 330 IRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGFNNTVEKL 374
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 288-457 2.90e-11

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 66.06  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 288 LSAVPYRDLTGGIVQIEKAISLTILVSLIIAYLIGFGFATSIIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGF 367
Cdd:COG3850   101 LLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAF 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 368 NNTVEKLSNLLEEvyvskLKEAEMSLKQKEVELKMLQSQMNPHFLYNSLETIRGMALEENQENIATMSFSLGKLLRYNLN 447
Cdd:COG3850   181 NRMADELQELYAE-----LEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLA 255

                         170
                  ....*....|
gi 2072564767 448 NHSSTVSFRE 457
Cdd:COG3850   256 LNILAGLLEL 265
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 306-381 3.69e-11

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 65.37  E-value: 3.69e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2072564767 306 AISLTILVSLIIAYLIGFGFATSIIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGFNNTVEKLSNLLEEV 381
Cdd:COG5000    10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREEL 85
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
328-379 1.78e-09

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 53.79  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2072564767  328 SIIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGFNNTVEKLSNLLE 379
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
PDC2_MCP_like cd12912
second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains; ...
 212-295 2.29e-09

second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the second PDC domain of Methyl-accepting chemotaxis proteins (MCPs), Histidine kinases (HKs), and other similar domains. Many members contain both HAMP (HK, Adenylyl cyclase, MCP, and Phosphatase) and MCP domains, which are signalling domains that interact with protein partners to relay a signal. MCPs are part of a transmembrane protein complex that controls bacterial chemotaxis. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350337 [Multi-domain]  Cd Length: 92  Bit Score: 54.70  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 212 IEEISNKVTISKNGYFSILDANGHYIYHPDYLKLGKRVEFKQLSNLKT--------EGSSTEILENERRdFVTYTFSRNL 283
Cdd:cd12912     2 LSEIISSIKIGETGYAFLVDKDGTIIAHPDKELVGKKISDDEAAEEELakkmlagkSGSVEYTFNGEKK-YVAYAPIPGT 80

                          90
                  ....*....|..
gi 2072564767 284 GWRFLSAVPYRD 295
Cdd:cd12912    81 GWSLVVVVPESE 92
HAMP pfam00672
HAMP domain;
325-374 1.90e-08

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 50.70  E-value: 1.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2072564767 325 FATSIIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGFNNTVEKL 374
Cdd:pfam00672   2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 497-602 7.33e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 50.73  E-value: 7.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767  497 LQPLVENCFVHGFGPNTrklkIVISAFRHSESsVVIRISDTGEGIKDHILEEIKKRM---DLKTATSDGKNIGIVNVHQR 573
Cdd:smart00387  10 LSNLLDNAIKYTPEGGR----ITVTLERDGDH-VEITVEDNGPGIPPEDLEKIFEPFfrtDKRSRKIGGTGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....*....
gi 2072564767  574 IHYLFGpeyGITIQSEQGSGTEVLIHLPI 602
Cdd:smart00387  85 VELHGG---EISVESEPGGGTTFTITLPL 110
PDC2_HK_sensor cd18774
second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, ...
 212-293 2.38e-07

second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.


Pssm-ID: 350342 [Multi-domain]  Cd Length: 89  Bit Score: 48.98  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 212 IEEISNKVTISKNGYFSILDANGHYIYHPDYLKLGKRV------EFKQLSNLKTEGSSTEILENERRDFVTYTFSRNLGW 285
Cdd:cd18774     2 LSDLLSSIKLGETGYAFLVDSDGTILAHPPKELVGKGKslddlaLLAALLLAGESGTFEYTSDDGVERLVAYRPVPGTPW 81


                  ....*...
gi 2072564767 286 RFLSAVPY 293
Cdd:cd18774    82 VVVVGVPE 89
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 497-601 7.31e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 48.13  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 497 LQPLVENCFVHGFGPNTRKLKIvisafrHSESSVVIRISDTGEGIKDHILEEIKKR-MDLKTATSDGKNIGIVNVHQRIH 575
Cdd:pfam02518  10 LSNLLDNALKHAAKAGEITVTL------SEGGELTLTVEDNGIGIPPEDLPRIFEPfSTADKRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....*.
gi 2072564767 576 YLFGPeygITIQSEQGSGTEVLIHLP 601
Cdd:pfam02518  84 LLGGT---ITVESEPGGGTTVTLTLP 106
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 513-610 1.64e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 48.01  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 513 TRKLKIVISAFRHSESSVVIRISDTGEGIKDHILEEI-------KKRMDLKTATsdGKNIGIVnVHQRIHYLFGPEygIT 585
Cdd:PRK11091  414 TQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIfamyyqvKDSHGGKPAT--GTGIGLA-VSKRLAQAMGGD--IT 488

                          90       100
                  ....*....|....*....|....*..
gi 2072564767 586 IQSEQGSGT--EVLIHLPILDHHVEEE 610
Cdd:PRK11091  489 VTSEEGKGScfTLTIHAPAVAEEVEDA 515
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 492-600 2.91e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 43.55  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 492 MVKFSLQPLVENcfVHGFGPNTRKLKIVISAFRHSessvVIRISDTGEGIKDHILEEIKK---RMDLKTATSDGKNIGIV 568
Cdd:cd16940    13 LLFLLLRNLVDN--AVRYSPQGSRVEIKLSADDGA----VIRVEDNGPGIDEEELEALFErfyRSDGQNYGGSGLGLSIV 86

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2072564767 569 nvhQRIHYLFGpeYGITIQSEQGSGTEVLIHL 600
Cdd:cd16940    87 ---KRIVELHG--GQIFLGNAQGGGLEAWVRL 113
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 500-602 3.67e-05

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 46.38  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 500 LVENCFVHGFGPNTRKLKIVISaFRHSESSVVIRISDTGEGIKDHILEEIKKRmdlKTATSDGKN--IGIVNVHQRIHyl 577
Cdd:COG3290   289 LLDNAIEAVEKLPEEERRVELS-IRDDGDELVIEVEDSGPGIPEELLEKIFER---GFSTKLGEGrgLGLALVKQIVE-- 362

                          90       100
                  ....*....|....*....|....*..
gi 2072564767 578 fgpEYG--ITIQSEQGSGTEVLIHLPI 602
Cdd:COG3290   363 ---KYGgtIEVESEEGEGTVFTVRLPK 386
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 297-399 2.56e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 43.91  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 297 TGGIVqiekaISLTILVSLIIAYLIGFGFA-TSIIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQltagfnntvekLS 375
Cdd:COG4192   323 QSGIL-----LLAIALLSLLLAVLINYFYVrRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGR-----------IA 386

                          90       100
                  ....*....|....*....|....
gi 2072564767 376 NLLeEVYVSKLKEAEMSLKQKEVE 399
Cdd:COG4192   387 RLL-RVFRDQAIEKTQELETEIEE 409
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 500-601 3.48e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 40.35  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 500 LVENCFvHGFGPNTRKLKIVISAFRHSESSVVIRISDTGEGIKDHILEEIKKRmDLKTATSDGKNIGIVNVHQRIHYLFG 579
Cdd:cd16915     8 LIDNAL-DALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFER-GVSTKGQGERGIGLALVRQSVERLGG 85

                          90       100
                  ....*....|....*....|..
gi 2072564767 580 peyGITIQSEQGSGTEVLIHLP 601
Cdd:cd16915    86 ---SITVESEPGGGTTFSIRIP 104
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
523-602 4.02e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 42.30  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 523 FRHSESSVVIRISDTGEGIkdhileeikkrmDLKTATSDGknIGIVNVHQRIHYLFGpeyGITIQSEQGSGTEVLIHLPI 602
Cdd:COG4585   187 LEVDDGELTLTVRDDGVGF------------DPEAAPGGG--LGLRGMRERAEALGG---TLTIGSAPGGGTRVRATLPL 249
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
500-602 4.66e-04

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 42.20  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 500 LVENCFVHGfGPNTRklkIVISAFRHsESSVVIRISDTGEGIKDHILEEIKKRMDLKTATSDGKNIG--------IVNVH 571
Cdd:COG2205   140 LLDNAIKYS-PPGGT---ITISARRE-GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGlglaivkrIVEAH 214

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2072564767 572 QrihylfgpeyG-ITIQSEQGSGTEVLIHLPI 602
Cdd:COG2205   215 G----------GtIWVESEPGGGTTFTVTLPL 236
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
416-602 1.06e-03

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 41.43  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 416 LETIRGMALEENQENIATMSFSLGKLLRY-------------NLNNHSSTVSFREEVNfcEMYLQIQKFRFEDRFEYMFD 482
Cdd:COG0642   132 LELLLEELDEEQREYLETILRSADRLLRLindlldlsrleagKLELEPEPVDLAELLE--EVVELFRPLAEEKGIELELD 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 483 IPQWVMELEMVKFSLQP----LVENCFVHGfGPNTRklkIVISAfRHSESSVVIRISDTGEGIKDHILEEIKKRMdlKTA 558
Cdd:COG0642   210 LPDDLPTVRGDPDRLRQvllnLLSNAIKYT-PEGGT---VTVSV-RREGDRVRISVEDTGPGIPPEDLERIFEPF--FRT 282

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2072564767 559 TSDGKNIG----------IVNVHQrihylfgpeyG-ITIQSEQGSGTEVLIHLPI 602
Cdd:COG0642   283 DPSRRGGGtglglaivkrIVELHG----------GtIEVESEPGKGTTFTVTLPL 327
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 102-605 1.76e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 41.04  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 102 SENRDQFIEPTRNTLKEAEYSRADITNITILLNNNQVIDTLGNRNFYPAAKMKEEYWYSSVPLNGMSMLVMRKLKLENKE 181
Cdd:COG3920     3 LALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 182 QPVISLVRRLYNPQTLLPVGMLIIDINFRRIEEISNKVTISKNGYFSILDANGHYIYHPDYLKLGKRVEFKQLSNLKTEG 261
Cdd:COG3920    83 ALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 262 SSTEILENERRDFVTYTFSRNLGWRFLSAVPYRDLTGGIVQIEKAISLTILVSLIIAYLIGFGFATSIIRPIRRLQHFMK 341
Cdd:COG3920   163 LAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 342 EVEIGKLDGRVRVDSNDEIGQLTAGFnntvekLSNLLEEVYVSKLKEAEMSLKQKEVELKMLQSQMNpHFLYNSLETIRG 421
Cdd:COG3920   243 RRRRARGLGRLLLLLLLLLLLLRALL------LLAAGIRLVITERKRAEEELEASLEEKELLLRELH-HRVKNNLQVVSS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 422 M---------------ALEENQENIATMSFSLGKLLRynlNNHSSTVSFREevnfcemYLQ-----IQKFRFEDRFEYMF 481
Cdd:COG3920   316 LlrlqarraddpeareALEESQNRIQALALVHELLYQ---SEDWEGVDLRD-------YLRellepLRDSYGGRGIRIEL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 482 DIPQWVMELEMVkfslQP-------LVENCFVHGFgPNTRKLKIVISaFRHSESSVVIRISDTGEGIKDHIleeikkrmD 554
Cdd:COG3920   386 DGPDVELPADAA----VPlglilneLVTNALKHAF-LSGEGGRIRVS-WRREDGRLRLTVSDNGVGLPEDV--------D 451

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2072564767 555 LKTATSDGKNIgivnVHQRIHYLFGpeygiTIQSEQGSGTEVLIHLPILDH 605
Cdd:COG3920   452 PPARKGLGLRL----IRALVRQLGG-----TLELDRPEGTRVRITFPLAEL 493
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 500-601 2.14e-03

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 39.49  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 500 LVENCFVHGF-GPNTRKLK-------IVISAFrHSESSVVIRISDTGEGI-KDHILEE-----IKKRMDLKTATSD---- 561
Cdd:cd16916    46 LLRNAVDHGIeAPEERLAAgkppegtITLRAE-HQGNQVVIEVSDDGRGIdREKIREKaiergLITADEAATLSDDevln 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2072564767 562 -----------------GKNIGIVNVHQRIHYLFGpeyGITIQSEQGSGTEVLIHLP 601
Cdd:cd16916   125 lifapgfstaeqvtdvsGRGVGMDVVKRSIESLGG---TIEVESEPGQGTTFTIRLP 178
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
493-602 2.27e-03

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 40.69  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 493 VKFSLQPLVENCFVHGfgpNTRKLKIVIS-----AFRHS-------------ESSVVIRISDTGEGIKDHILEEIKKRMd 554
Cdd:COG5002   262 IELELDLPEDPLLVLG---DPDRLEQVLTnlldnAIKYTpeggtitvslreeDDQVRISVRDTGIGIPEEDLPRIFERF- 337

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072564767 555 LKTATSDGKNIG-----------IVNVHQrihylfgpeyG-ITIQSEQGSGTEVLIHLPI 602
Cdd:COG5002   338 YRVDKSRSRETGgtglglaivkhIVEAHG----------GrIWVESEPGKGTTFTITLPL 387
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
309-373 9.31e-03

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 38.85  E-value: 9.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2072564767 309 LTILVSLIIAYLIGFGFatsiIRPIRRLQHFMKEVEIGKLDGRVRVDSNDEIGQLTAGFN---NTVEK 373
Cdd:PRK10549  172 LSTLLAALATFLLARGL----LAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNqlaSTLEK 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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