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Conserved domains on  [gi|2073083126|ref|WP_219024024|]
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IS3-like element IS3 family transposase [Escherichia coli]

Protein Classification

transposase family protein( domain architecture ID 1750059)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0006313
PubMed:  11774877

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
18-382 8.43e-147

IS3 family transposase;


:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 420.43  E-value: 8.43e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  18 EFRSEALKLAERIGVTAA--ARELSLYESQLYNWRSKQQNQQTSSERE------LEMSTEIARLKRQLAERDEELAILPK 89
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAevARELGISPSTLYRWRKKYRGGGEAADAGrlkellTPEEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  90 GRDILReaPEMKYVFIEKHQAEFSIKAMCRVLRVAHSGWYTWCQRRTriSTRQQFRQHCDSVVLAAFTRSKQRYGAPRLT 169
Cdd:NF033516   81 ARKLLR--PAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWRKRPP--SRRAPDDAELRARIREIFEESRGRYGYRRIT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 170 DELRAQGYPFNVKTVAASLRRQGLRAKASRKFSPV-SYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLA 248
Cdd:NF033516  157 ALLRREGIRVNHKRVYRLMRELGLLARRRRKRRPYtTDSGHVHPVAPNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 249 VVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSMSAKGCCYDNAC 328
Cdd:NF033516  237 VVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAV 316

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2073083126 329 VESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSPEQFE 382
Cdd:NF033516  317 AESFFGTLKRECLYRRRFRTLEEARQAIEEYIE-FYNHERPHSSLGYLTPAEFE 369
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
18-382 8.43e-147

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 420.43  E-value: 8.43e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  18 EFRSEALKLAERIGVTAA--ARELSLYESQLYNWRSKQQNQQTSSERE------LEMSTEIARLKRQLAERDEELAILPK 89
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAevARELGISPSTLYRWRKKYRGGGEAADAGrlkellTPEEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  90 GRDILReaPEMKYVFIEKHQAEFSIKAMCRVLRVAHSGWYTWCQRRTriSTRQQFRQHCDSVVLAAFTRSKQRYGAPRLT 169
Cdd:NF033516   81 ARKLLR--PAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWRKRPP--SRRAPDDAELRARIREIFEESRGRYGYRRIT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 170 DELRAQGYPFNVKTVAASLRRQGLRAKASRKFSPV-SYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLA 248
Cdd:NF033516  157 ALLRREGIRVNHKRVYRLMRELGLLARRRRKRRPYtTDSGHVHPVAPNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 249 VVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSMSAKGCCYDNAC 328
Cdd:NF033516  237 VVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAV 316

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2073083126 329 VESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSPEQFE 382
Cdd:NF033516  317 AESFFGTLKRECLYRRRFRTLEEARQAIEEYIE-FYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
76-387 1.68e-97

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 292.83  E-value: 1.68e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  76 QLAERDEELAILPKGRDILREAPEMKYVFIEKHQAEFSIKAMCRVLRVAHSGWYTWCQRRTRISTRQQFRQHCDSVVLAA 155
Cdd:COG2801     1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAELLERIKEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 156 FTRSKqRYGAPRLTDELRAQGYPFNVKTVAASLRRQGLRAKASRKFSPVSYRAHGLPVSENLLeqdFYASGPNQKWAGDI 235
Cdd:COG2801    81 FAESP-RYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGPIAPNLL---FTATAPNQVWVTDI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 236 TYLRTDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRG 315
Cdd:COG2801   157 TYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPPKPLILHSDNGSQYTSKAYQELLKKLGITQ 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2073083126 316 SMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSPEQFENKNLA 387
Cdd:COG2801   237 SMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIE-FYNHERPHSSLGYLTPAEYEKQLAA 307
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 121-387 2.40e-65

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 209.34  E-value: 2.40e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 121 LRVAHSGWYTWCQRRTRISTRQQFRQHCD---SVVLAAFTRSKQRYGAPRLTDELRAQGYPFNVKTVAASLRRQGLRA-- 195
Cdd:PHA02517    1 LGIAPSTYYRCQQQRHHPDKRRARAQHDDwlkSEILRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGvl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 196 KASRKFSPVSYRAHGLPvseNLLEQDFYASGPNQKWAGDITYLRTDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDA 275
Cdd:PHA02517   81 RGKKVRTTISRKAVAAP---DRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 276 LQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRAT 355
Cdd:PHA02517  158 LEQALWARGRPGGLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELA 237

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2073083126 356 VFNYIECdYNRWRRHSWCGGLSPEQFENKNLA 387
Cdd:PHA02517  238 TLEWVAW-YNNRRLHERLGYTPPAEAEKAYYA 268
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 227-323 2.59e-27

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 2.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 227 PNQKWAGDITYLR--TDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKrPRNVIVHTDRGGQYCSADY 304
Cdd:pfam00665   1 PNQLWQGDFTYIRipGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRG-GVPLIIHSDNGSEYTSKAF 79

                          90
                  ....*....|....*....
gi 2073083126 305 QAQLKRHNLRGSMSAKGCC 323
Cdd:pfam00665  80 REFLKDLGIKPSFSRPGNP 98
transpos_IS481 NF033577
IS481 family transposase; null
 158-378 1.40e-12

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 67.62  E-value: 1.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 158 RSKQRYGAPRLTDELRAQGYPFNVKTVAASLRRQGL---RAKASRKFSPVSY-RAHglpvsenlleqdfyasgPNQKWAG 233
Cdd:NF033577   71 RRELRLGPRRIAYELERQGPGVSRSTVHRILRRHGLsrlRALDRKTGKVKRYeRAH-----------------PGELWHI 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 234 DITYLRT--DEGWLYLAVVIDLWSRAVIGwSMSPRMTAQLACDALQMALwrRKRP-RNVIVHTDRGGQYCS--ADYQAQL 308
Cdd:NF033577  134 DIKKLGRipDVGRLYLHTAIDDHSRFAYA-ELYPDETAETAADFLRRAF--AEHGiPIRRVLTDNGSEFRSraHGFELAL 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 309 KRHNLRGSMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSP 378
Cdd:NF033577  211 AELGIEHRRTRPYHPQTNGKVERFHRTLKDEFAYARPYESLAELQAALDEWLH-HYNHHRPHSALGGKTP 279
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
18-382 8.43e-147

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 420.43  E-value: 8.43e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  18 EFRSEALKLAERIGVTAA--ARELSLYESQLYNWRSKQQNQQTSSERE------LEMSTEIARLKRQLAERDEELAILPK 89
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAevARELGISPSTLYRWRKKYRGGGEAADAGrlkellTPEEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  90 GRDILReaPEMKYVFIEKHQAEFSIKAMCRVLRVAHSGWYTWCQRRTriSTRQQFRQHCDSVVLAAFTRSKQRYGAPRLT 169
Cdd:NF033516   81 ARKLLR--PAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWRKRPP--SRRAPDDAELRARIREIFEESRGRYGYRRIT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 170 DELRAQGYPFNVKTVAASLRRQGLRAKASRKFSPV-SYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLA 248
Cdd:NF033516  157 ALLRREGIRVNHKRVYRLMRELGLLARRRRKRRPYtTDSGHVHPVAPNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 249 VVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSMSAKGCCYDNAC 328
Cdd:NF033516  237 VVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAV 316

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2073083126 329 VESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSPEQFE 382
Cdd:NF033516  317 AESFFGTLKRECLYRRRFRTLEEARQAIEEYIE-FYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
76-387 1.68e-97

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 292.83  E-value: 1.68e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126  76 QLAERDEELAILPKGRDILREAPEMKYVFIEKHQAEFSIKAMCRVLRVAHSGWYTWCQRRTRISTRQQFRQHCDSVVLAA 155
Cdd:COG2801     1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAELLERIKEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 156 FTRSKqRYGAPRLTDELRAQGYPFNVKTVAASLRRQGLRAKASRKFSPVSYRAHGLPVSENLLeqdFYASGPNQKWAGDI 235
Cdd:COG2801    81 FAESP-RYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGPIAPNLL---FTATAPNQVWVTDI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 236 TYLRTDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRG 315
Cdd:COG2801   157 TYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPPKPLILHSDNGSQYTSKAYQELLKKLGITQ 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2073083126 316 SMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSPEQFENKNLA 387
Cdd:COG2801   237 SMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIE-FYNHERPHSSLGYLTPAEYEKQLAA 307
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 121-387 2.40e-65

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 209.34  E-value: 2.40e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 121 LRVAHSGWYTWCQRRTRISTRQQFRQHCD---SVVLAAFTRSKQRYGAPRLTDELRAQGYPFNVKTVAASLRRQGLRA-- 195
Cdd:PHA02517    1 LGIAPSTYYRCQQQRHHPDKRRARAQHDDwlkSEILRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGvl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 196 KASRKFSPVSYRAHGLPvseNLLEQDFYASGPNQKWAGDITYLRTDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDA 275
Cdd:PHA02517   81 RGKKVRTTISRKAVAAP---DRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 276 LQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRAT 355
Cdd:PHA02517  158 LEQALWARGRPGGLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELA 237

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2073083126 356 VFNYIECdYNRWRRHSWCGGLSPEQFENKNLA 387
Cdd:PHA02517  238 TLEWVAW-YNNRRLHERLGYTPPAEAEKAYYA 268
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 227-323 2.59e-27

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 2.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 227 PNQKWAGDITYLR--TDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKrPRNVIVHTDRGGQYCSADY 304
Cdd:pfam00665   1 PNQLWQGDFTYIRipGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRG-GVPLIIHSDNGSEYTSKAF 79

                          90
                  ....*....|....*....
gi 2073083126 305 QAQLKRHNLRGSMSAKGCC 323
Cdd:pfam00665  80 REFLKDLGIKPSFSRPGNP 98
rve_2 pfam13333
Integrase core domain;
330-386 2.03e-19

Integrase core domain;


Pssm-ID: 372570 [Multi-domain]  Cd Length: 52  Bit Score: 80.77  E-value: 2.03e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2073083126 330 ESFFHSLKVECIHGEHFISREIMRATVFNYIECdYNRWRRHswcgGLSPEQFENKNL 386
Cdd:pfam13333   1 ESFFGSLKTEMVYGEHFKTLEELELAIFDYIEW-YNNKRLK----GLSPVQYRNQSL 52
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
9-94 2.39e-13

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 65.33  E-value: 2.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126   9 KKPRKQHSPEFRSEALKLAERIGVT--AAARELSLYESQLYNWRSKQQNQQTSS----ERELEMSTEIARLKRQLAERDE 82
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASvaEVARELGISPSTLYRWVRQYREGGLGGfpgdGRTTPEQAEIRRLRKELRRLEM 81

                          90
                  ....*....|..
gi 2073083126  83 ELAILPKGRDIL 94
Cdd:COG2963    82 ENDILKKAAALL 93
transpos_IS481 NF033577
IS481 family transposase; null
 158-378 1.40e-12

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 67.62  E-value: 1.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 158 RSKQRYGAPRLTDELRAQGYPFNVKTVAASLRRQGL---RAKASRKFSPVSY-RAHglpvsenlleqdfyasgPNQKWAG 233
Cdd:NF033577   71 RRELRLGPRRIAYELERQGPGVSRSTVHRILRRHGLsrlRALDRKTGKVKRYeRAH-----------------PGELWHI 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 234 DITYLRT--DEGWLYLAVVIDLWSRAVIGwSMSPRMTAQLACDALQMALwrRKRP-RNVIVHTDRGGQYCS--ADYQAQL 308
Cdd:NF033577  134 DIKKLGRipDVGRLYLHTAIDDHSRFAYA-ELYPDETAETAADFLRRAF--AEHGiPIRRVLTDNGSEFRSraHGFELAL 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 309 KRHNLRGSMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSP 378
Cdd:NF033577  211 AELGIEHRRTRPYHPQTNGKVERFHRTLKDEFAYARPYESLAELQAALDEWLH-HYNHHRPHSALGGKTP 279
rve_3 pfam13683
Integrase core domain;
316-378 1.52e-08

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 51.06  E-value: 1.52e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2073083126 316 SMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIEcDYNRWRRHSWCGGLSP 378
Cdd:pfam13683   6 SYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWRE-DYNTERPHSSLGYRTP 67
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 151-201 7.91e-08

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 48.72  E-value: 7.91e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2073083126 151 VVLAAFTRSKQRYGAPRLTDELRAQGY-PFNVKTVAASLRRQGLRAKASRKF 201
Cdd:pfam13276   9 AIREIFEESRGTYGYRRITAELRREGGiRVNRKRVARLMRELGLRARRRRKR 60
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 9-78 1.57e-07

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 48.12  E-value: 1.57e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2073083126   9 KKPRKQHSPEFRSEALKLAERIGVTAA--ARELSLYESQLYNWRSKQQNQQTSSE---RELEMSTEIARLKRQLA 78
Cdd:pfam01527   1 MKKRRRFSEEFKLRAVKEVLEPGRTVKevARRHGVSPNTLYQWRRQYEGGMGASParpRLTALEEENRRLKRELA 75
DDE_Tnp_IS240 pfam13610
DDE domain; This DDE domain is found in a wide variety of transposases including those found ...
 231-370 5.17e-03

DDE domain; This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.


Pssm-ID: 433347 [Multi-domain]  Cd Length: 138  Bit Score: 36.96  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073083126 231 WAGDITYLRTDEGWLYLAVVIDLWSRaVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVhTDRGGQYCSAdyqaqLKR 310
Cdd:pfam13610   3 WRVDETYVKVKGKWHYVYRAVDKEGN-TLDFYVSKRRDTDAAKAFLRRALKNYKGRPEEIV-TDKAGAYLSA-----IKE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2073083126 311 HNLRGSMSAKGCCYD----NACVESFFHSLKVECIHGEHFISREIMRATVFNYiECDYNRWRRH 370
Cdd:pfam13610  76 LKPSGLLLDDIRHVTvkylNNRIESDHRPLKKRLRPMRGFKSFKSARKTIAGF-EVVHNLRKGH 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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