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Conserved domains on  [gi|2073457023|ref|WP_219143983|]
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MULTISPECIES: sulfurtransferase TusA family protein [Aeromonas]

Protein Classification

sulfurtransferase TusA family protein( domain architecture ID 10471957)

sulfurtransferase TusA family protein similar to sulfurtransferase TusA, which interacts with cysteine desulfurase IscS and acts as the first member in a sulfur relay mechanism, transfering sulfur to the TusBCD complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 3-61 3.18e-17

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


:

Pssm-ID: 426125  Cd Length: 64  Bit Score: 68.37  E-value: 3.18e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDVRPLEES 61
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEEE 59
 
Name Accession Description Interval E-value
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 3-61 3.18e-17

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 68.37  E-value: 3.18e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDVRPLEES 61
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEEE 59
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 4-55 5.32e-17

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 67.91  E-value: 5.32e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2073457023  4 LDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDV 55
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHEL 52
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 3-69 4.18e-16

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 65.65  E-value: 4.18e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDVRPLEESATRLSLLL 69
Cdd:cd00291    1 TLDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEVEEEGGVYRILI 67
PRK00299 PRK00299
sulfurtransferase TusA;
3-54 4.40e-09

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 48.09  E-value: 4.40e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHD 54
Cdd:PRK00299  11 TLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHE 62
 
Name Accession Description Interval E-value
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 3-61 3.18e-17

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 68.37  E-value: 3.18e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDVRPLEES 61
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEEE 59
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 4-55 5.32e-17

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 67.91  E-value: 5.32e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2073457023  4 LDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDV 55
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHEL 52
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 3-69 4.18e-16

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 65.65  E-value: 4.18e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDVRPLEESATRLSLLL 69
Cdd:cd00291    1 TLDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEVEEEGGVYRILI 67
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 3-53 1.78e-10

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 51.59  E-value: 1.78e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGH 53
Cdd:cd03423    1 ILDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGH 51
PRK00299 PRK00299
sulfurtransferase TusA;
3-54 4.40e-09

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 48.09  E-value: 4.40e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHD 54
Cdd:PRK00299  11 TLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHE 62
SirA_RHOD_Pry_redox cd03420
SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown ...
 3-62 3.73e-07

SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that corresponds to COG2210. This fold is referred to as a two-layered alpha/beta sandwich, structurally similar to that of translation initiation factor 3.


Pssm-ID: 239512  Cd Length: 69  Bit Score: 43.13  E-value: 3.73e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073457023  3 QLDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDVRPLEESA 62
Cdd:cd03420    1 EVDACGLQCPGPILKLKKEIDKLQDGEQLEVKASDPGFARDAQAWCKSTGNTLISLETEK 60
YedF cd03422
YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and ...
 4-69 4.72e-03

YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239514  Cd Length: 69  Bit Score: 32.40  E-value: 4.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2073457023  4 LDLTPWRCPEPLIRLKLWLRQARPGQSLLILLGDPGSRQDIPAYLRRQGHDVRPLEESATRLSLLL 69
Cdd:cd03422    2 LDLRGEPCPYPAIATLEALPSLKPGEILEVISDCPQSINNIPIDARNHGYKVLAIEQSGPTIRYLI 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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