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Conserved domains on  [gi|2073796971|ref|WP_219245214|]
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MULTISPECIES: multidrug transporter subunit MdtD [Providencia]

Protein Classification

MFS transporter( domain architecture ID 1001490)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  9529885|26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10504 super family cl32521
putative transporter; Provisional
 13-446 1.76e-134

putative transporter; Provisional


The actual alignment was detected with superfamily member PRK10504:

Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 396.02  E-value: 1.76e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:PRK10504   13 WIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:PRK10504   93 ALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 173 IGVLGVFYALKHMPDFKMPKRKFDTLGFLLFGFGLVMLSVSLDLFGDKALPTSIPAAIVGGGFLFLLLYVFHARRIKHAI 252
Cdd:PRK10504  173 VGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 253 IPLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFV 332
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 333 ITVIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAI 412
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLL 412

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2073796971 413 LNFYDGQ------PNSNTVdnFHYTFITIGVITLVSAFVF 446
Cdd:PRK10504  413 LGLFGQQhvsvdsGATHTV--FMYTYLCMALIIALPALIF 450
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 13-446 1.76e-134

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 396.02  E-value: 1.76e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:PRK10504   13 WIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:PRK10504   93 ALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 173 IGVLGVFYALKHMPDFKMPKRKFDTLGFLLFGFGLVMLSVSLDLFGDKALPTSIPAAIVGGGFLFLLLYVFHARRIKHAI 252
Cdd:PRK10504  173 VGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 253 IPLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFV 332
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 333 ITVIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAI 412
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLL 412

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2073796971 413 LNFYDGQ------PNSNTVdnFHYTFITIGVITLVSAFVF 446
Cdd:PRK10504  413 LGLFGQQhvsvdsGATHTV--FMYTYLCMALIIALPALIF 450
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 15-450 3.62e-92

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 284.47  E-value: 3.62e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  15 AAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCAL 94
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  95 SPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIG 174
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 175 VLGVFYAlkhmpdfkmpkrkfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflllyvfharrikhAIIP 254
Cdd:cd17503   161 ILALLLA---------------------------------------------------------------------PLLD 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 255 LNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVIT 334
Cdd:cd17503   172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 335 VIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAILN 414
Cdd:cd17503   252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2073796971 415 -------------FYDGQPNSNTVDNFHYTFITIGVITLVSAFVFLLLS 450
Cdd:cd17503   332 nrtqfhhsrlselLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-413 2.42e-54

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 189.13  E-value: 2.42e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  17 MAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSP 96
Cdd:TIGR00711   9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  97 SLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 177 GVFYALKHMPDFKMP-KRKFDTLGFLLFGFGLVMLSVSLDLFGDKALPTS----IPAAIVGGGFLFLLLyvfHARRIKHA 251
Cdd:TIGR00711 169 VVVVAFFILPRDKPAaSENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSneilILSITGLVAIIAFVV---WELTDDNP 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 252 IIPLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLF 331
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVT 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 332 VITVIIGLMIAQFSLQ-SPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSA 410
Cdd:TIGR00711 326 IGLILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALIT 405


                  ...
gi 2073796971 411 AIL 413
Cdd:TIGR00711 406 TIL 408
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-403 6.98e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 149.35  E-value: 6.98e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971   1 MFKTAKNMSGLPWIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFIL 80
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  81 AVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTY 160
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 161 ATWHWIFIINIPIGVLGVFYALKHMPDFKMPKRkfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflll 240
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAAR----------------------------------------------- 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 241 yvfhaRRIKHAIipLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKI 320
Cdd:COG2814   194 -----ARLRGSL--RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 321 LTKYGYRNTLFVITVIIGLMIAQFSLQSpnmSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQL 400
Cdd:COG2814   267 ADRFGRRRLLLIGLLLLALGLLLLALAG---SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                  ...
gi 2073796971 401 SIS 403
Cdd:COG2814   344 GGP 346
MFS_1 pfam07690
Major Facilitator Superfamily;
16-405 7.75e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.59  E-value: 7.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQALDATILNTALP-DIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCAL 94
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  95 SPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIG 174
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 175 VLGVFYALKHMPDFKMPKRKfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflllyvFHARRIKHAIIP 254
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPK------------------------------------------------PAEEARLSLIVA 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 255 LNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVgFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVIT 334
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2073796971 335 VIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFG 405
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_effux_SdrM NF040895
multidrug efflux MFS transporter SdrM;
20-176 6.29e-22

multidrug efflux MFS transporter SdrM;


Pssm-ID: 468830 [Multi-domain]  Cd Length: 441  Bit Score: 97.73  E-value: 6.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  20 FMQALDATILNTALPDIAKSLH-HSPLAMQSAVvsYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSL 98
Cdd:NF040895   16 FMAAIETSIISLALPTIKEDLNaGSSISLVFTV--YFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSLMSGLSETF 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2073796971  99 NFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:NF040895   94 TMLIISRIIQGLGAGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFFINIPIAII 171
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 13-446 1.76e-134

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 396.02  E-value: 1.76e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:PRK10504   13 WIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:PRK10504   93 ALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 173 IGVLGVFYALKHMPDFKMPKRKFDTLGFLLFGFGLVMLSVSLDLFGDKALPTSIPAAIVGGGFLFLLLYVFHARRIKHAI 252
Cdd:PRK10504  173 VGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 253 IPLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFV 332
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 333 ITVIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAI 412
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLL 412

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2073796971 413 LNFYDGQ------PNSNTVdnFHYTFITIGVITLVSAFVF 446
Cdd:PRK10504  413 LGLFGQQhvsvdsGATHTV--FMYTYLCMALIIALPALIF 450
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 15-450 3.62e-92

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 284.47  E-value: 3.62e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  15 AAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCAL 94
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  95 SPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIG 174
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 175 VLGVFYAlkhmpdfkmpkrkfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflllyvfharrikhAIIP 254
Cdd:cd17503   161 ILALLLA---------------------------------------------------------------------PLLD 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 255 LNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVIT 334
Cdd:cd17503   172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 335 VIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAILN 414
Cdd:cd17503   252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2073796971 415 -------------FYDGQPNSNTVDNFHYTFITIGVITLVSAFVFLLLS 450
Cdd:cd17503   332 nrtqfhhsrlselLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-413 2.42e-54

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 189.13  E-value: 2.42e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  17 MAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSP 96
Cdd:TIGR00711   9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  97 SLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 177 GVFYALKHMPDFKMP-KRKFDTLGFLLFGFGLVMLSVSLDLFGDKALPTS----IPAAIVGGGFLFLLLyvfHARRIKHA 251
Cdd:TIGR00711 169 VVVVAFFILPRDKPAaSENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSneilILSITGLVAIIAFVV---WELTDDNP 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 252 IIPLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLF 331
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVT 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 332 VITVIIGLMIAQFSLQ-SPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSA 410
Cdd:TIGR00711 326 IGLILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALIT 405


                  ...
gi 2073796971 411 AIL 413
Cdd:TIGR00711 406 TIL 408
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 16-449 7.56e-54

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 184.68  E-value: 7.56e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALS 95
Cdd:cd17321     2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  96 PSLNFLVTSRVIQGIGGAMMMPVArLALIRA-YPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIG 174
Cdd:cd17321    82 PSLAFLIAARALQGIGAAAIMPAS-LALIAAtFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 175 VLGVFYAlkhmpdfkmpkrkfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflllyvfharrikhaiip 254
Cdd:cd17321   161 LVALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 255 lnlfktRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVIT 334
Cdd:cd17321   168 ------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 335 VIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAIL- 413
Cdd:cd17321   242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLt 321

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2073796971 414 ------------NFYDGQPNSNTVDNFHYTFITIGVITLVSAFVFLLL 449
Cdd:cd17321   322 aglsanlgdsgvAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLL 369
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-403 6.98e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 149.35  E-value: 6.98e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971   1 MFKTAKNMSGLPWIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFIL 80
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  81 AVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTY 160
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 161 ATWHWIFIINIPIGVLGVFYALKHMPDFKMPKRkfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflll 240
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAAR----------------------------------------------- 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 241 yvfhaRRIKHAIipLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKI 320
Cdd:COG2814   194 -----ARLRGSL--RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 321 LTKYGYRNTLFVITVIIGLMIAQFSLQSpnmSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQL 400
Cdd:COG2814   267 ADRFGRRRLLLIGLLLLALGLLLLALAG---SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                  ...
gi 2073796971 401 SIS 403
Cdd:COG2814   344 GGP 346
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 13-301 5.39e-36

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 134.94  E-value: 5.39e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:COG0477    17 LALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:COG0477    97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 173 IGVLGVFYALkhmpdfkmpkRKFDTLGFLLFGFGLVMLSVSLDLFGDKALPTSIPAAIVGGGFLFLLLYVFHARRIKHAI 252
Cdd:COG0477   177 LGLLALVLRL----------RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2073796971 253 IPLNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGM 301
Cdd:COG0477   247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 17-411 6.60e-34

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 129.99  E-value: 6.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  17 MAFFMQALDATILNTALPDIAKSLHHSPLaMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSP 96
Cdd:cd17502     3 LALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  97 SLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:cd17502    82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 177 gvfyalkhmpdfkmpkrkfdtlgfllfgfglvmlsvsldlfgdkalptsipAAIVGGGFLFLLLYVFharrikhaiipln 256
Cdd:cd17502   162 ---------------------------------------------------ALALLRTILLSSIFGF------------- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 257 lfktrTFSIGISGNIatrlgtgsipFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVITVI 336
Cdd:cd17502   178 -----LFGGALFGLI----------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTI 242

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2073796971 337 IGLM-IAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAA 411
Cdd:cd17502   243 LMSVgAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDV 318
MFS_1 pfam07690
Major Facilitator Superfamily;
16-405 7.75e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.59  E-value: 7.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQALDATILNTALP-DIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCAL 94
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  95 SPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIG 174
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 175 VLGVFYALKHMPDFKMPKRKfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflllyvFHARRIKHAIIP 254
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPK------------------------------------------------PAEEARLSLIVA 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 255 LNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVgFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVIT 334
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2073796971 335 VIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFG 405
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 16-449 1.56e-26

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 110.36  E-value: 1.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALS 95
Cdd:cd17504     2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  96 PSLNFLVTSRVIQGIGGAmMMPVArLALIRAYPRSELLPI-LNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIG 174
Cdd:cd17504    82 PNLPVLIAGRALQGIGGA-VFPLA-FALVREEFPPERVPVaQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 175 VLGVFYAlkhmpdfkmpkrkfdtlgfllfgfglvmlsvsldlfgdkalptsipaaivgggflflllyvfharrikhAIIP 254
Cdd:cd17504   160 VLLAALV---------------------------------------------------------------------PLID 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 255 LNLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQ----VGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTL 330
Cdd:cd17504   171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 331 FVITVIIGLMIAQFSLQSPnmSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSA 410
Cdd:cd17504   251 LIGLVISAVGLLLLALLHS--SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2073796971 411 AILNFYDGQPNSNTVDN---FHYTFITIGVITLVSAFVFLLL 449
Cdd:cd17504   329 AILTTYTVSITSGGVPTegaYVLAFLIGAALALAALLLSLLI 370
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 11-446 1.59e-23

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 101.88  E-value: 1.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  11 LPWIAAMAFFMQaLDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSL 90
Cdd:cd17320     1 LLLLALLVALGP-LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  91 LCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIIN 170
Cdd:cd17320    80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 171 IPIGVLGVFYALKHMPDFKMPKRkfdtlgflLFGFGLVMLSVSLDLFGDKALPTSipAAIVGGGFLFLLLYVFHArrikh 250
Cdd:cd17320   160 ALLGLLLLLLVLLFLPETLPEEK--------RKPLLSSLLRAYKRVLKNRRFLGY--ALALGLSFAGLFAYLAAA----- 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 251 aiiplnlfktrtfsigisgniatrlgtgsipflmPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTL 330
Cdd:cd17320   225 ----------------------------------PFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 331 ---FVITVIIGLMIAQFSLQSPnMSIYLLVVPLFILGMVMSVQFTAMNTICLADLtDNNASAGNSMLAVTQQLSISFGIA 407
Cdd:cd17320   271 rlgLLLLLAAALVLLLAALLGG-LSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGALAGA 348

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 2073796971 408 VSAAILNfydgqpnsNTVDNFHYTFITIGVITLVSAFVF 446
Cdd:cd17320   349 LVGLLPN--------GTALPMGLLILVLGLLALLLLILL 379
PRK14995 PRK14995
SmvA family efflux MFS transporter;
23-310 1.11e-22

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 100.57  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  23 ALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLV 102
Cdd:PRK14995   19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 103 TSRVIQGIGGAMMMPvARLALIRAY---PRSELLPILNFVTIpGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVF 179
Cdd:PRK14995   99 ATRALLAIGAAMIVP-ATLAGIRATfteEKQRNMALGVWAAV-GSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 180 YALKHMPDFKM-PKRKFDTLGFLLFGFGLVML--SVSLDLFGDKALPTSIPAAIVGGGFLFllLYVFHARRIKHAIIPLN 256
Cdd:PRK14995  177 LTARYVPRQAGrRDQPLNLGHALMLIVAILLLvySAKTALKGFLSLWVTSLTLLTGALLLG--LFIRTQLAASRPMIDMR 254

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2073796971 257 LFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGS 310
Cdd:PRK14995  255 LFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVAS 308
MFS_effux_SdrM NF040895
multidrug efflux MFS transporter SdrM;
20-176 6.29e-22

multidrug efflux MFS transporter SdrM;


Pssm-ID: 468830 [Multi-domain]  Cd Length: 441  Bit Score: 97.73  E-value: 6.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  20 FMQALDATILNTALPDIAKSLH-HSPLAMQSAVvsYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSL 98
Cdd:NF040895   16 FMAAIETSIISLALPTIKEDLNaGSSISLVFTV--YFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSLMSGLSETF 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2073796971  99 NFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:NF040895   94 TMLIISRIIQGLGAGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFFINIPIAII 171
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 13-377 2.09e-20

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 92.63  E-value: 2.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:cd17474     2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYAtWHWIF---II 169
Cdd:cd17474    82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRYPFfllAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 170 NIPIGVLGVFYALKHMPDFKMPKRKFDTLGFLLFGFGLVMLSVSLdlfgdkalptsipaaivgGGFLFLLLYvfharrik 249
Cdd:cd17474   161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLV------------------SAFLYFFLY-------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 250 haiiplnlfktrtfsigisgniatrlgtGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTK-YGYRN 328
Cdd:cd17474   215 ----------------------------FAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARR 266

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2073796971 329 TLFVITVIIGLMIAQFSLQSpnmSIYLLVVPLFILGMVMSVQFTAMNTI 377
Cdd:cd17474   267 ILVIGLLLYALSLLLLGFVP---SLALLLIAIVLFGLGLGLNLPLLTTL 312
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-182 8.29e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 90.70  E-value: 8.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:COG2271    13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:COG2271    93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                         170
                  ....*....|
gi 2073796971 173 IGVLGVFYAL 182
Cdd:COG2271   173 PGLLLALLRF 182
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 16-450 1.21e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 84.16  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALS 95
Cdd:cd17325     2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  96 PSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGV 175
Cdd:cd17325    82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 176 LGVFYALKHMPDFKMPKRKFDTLGFLLFGFGLVMLSvsldlfgDKALPTSIPAAIVGGgflflllyvfharrikhaiipl 255
Cdd:cd17325   162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLR-------DRRLLALFLAIFVLA---------------------- 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 256 nlfktrtfsigisgniatrLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVITV 335
Cdd:cd17325   213 -------------------FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 336 IIGLMIAQFSLQSpnmSIYLLVVPLFILGMVMSVQFTAMNTIcLADLTDNNA-SAGNSMLAVTQQLSISFGIAVSAAILN 414
Cdd:cd17325   274 LSAVALLLLPLAT---SFWLLLLLLALLGLGLGLVFPATLAL-LADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYD 349

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2073796971 415 FYdgqpnsntvdNFHYTFITIGVITLVSAFVFLLLS 450
Cdd:cd17325   350 AF----------GFATPFLAAAALLLLAAVLFLLLR 375
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 14-179 6.49e-17

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 81.92  E-value: 6.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCA 93
Cdd:cd17476     2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  94 LSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYP---RSELLPILNFVTIPglIGPILGPLLGGILVTYATWHWIF--- 167
Cdd:cd17476    82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPpgpRKNIVFSLFGATAP--LGFALGGVFGGLFAQLAWWPWIFwfl 159

                         170
                  ....*....|...
gi 2073796971 168 -IINIPIGVLGVF 179
Cdd:cd17476   160 aILAAIVAVAAIF 172
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 14-414 1.22e-16

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 82.29  E-value: 1.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQsAVVSYTLTVALLIPISGWFADRFGtRRIFILAVSLFSF-GSLLC 92
Cdd:cd06179     2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTW-ISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGVvGSIVA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAM--MMPVARLALIrayPRSELLPILNFVTIPGLIGPILGPLLGGILV--TYATWHWIFI 168
Cdd:cd06179    80 GTAKSVNMLIGGQALIGIGAGTqgLGAAVASELV---PNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 169 INIPIGVLGV--FYALKHMPDFKMPK--------RKFDTLGFLLFGFGLVMLSVSLDLFGDKALPTSIP--AAIVGGGFL 236
Cdd:cd06179   157 INAIFNALALilLFFFYHPPPRPQLHgsstrqklKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHviAPLVIGGVL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 237 FLLLYVFHAR-RIKHAIIPLNLFKTRTFSIgisgnIATRLGTGSIPF-----LMPLMLQVGFGYEAVVAGMMMAPLAIGS 310
Cdd:cd06179   237 LIAFGLYEWKgTKDGLLPPRLLFRGRNFAL-----ILIVAFVEGMIFyslniFWPQQISLLFTTDPLKAGLYQLPFGLGT 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 311 ITAKSGVTKILTKYGY-RNTLFVITVIIGLMIAQFSLQSPNMSIyLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASA 389
Cdd:cd06179   312 LFGAILAGLLLTKIKHiKWQLVAGFVLFTAFLALLALITPDNKA-LAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGT 390

                         410       420
                  ....*....|....*....|....*
gi 2073796971 390 GNSMLAVTQQLSISFGIAVSAAILN 414
Cdd:cd06179   391 ASGLLGSARALGGAVGTAIFTSILS 415
2_A_01_02 TIGR00880
Multidrug resistance protein;
51-187 2.04e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 75.76  E-value: 2.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  51 VVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRS 130
Cdd:TIGR00880   4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2073796971 131 ELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALKHMPD 187
Cdd:TIGR00880  84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 32-450 1.83e-15

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 77.61  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  32 ALPDIAKSLH-HSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGI 110
Cdd:cd17473    21 ALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 111 GGAMMMPVArLALIRAYPR-SELLPILNFVTIPGLIGPILGPLLGGILVTYaTWHWIFII---NIPIGVLGVFYALKHMP 186
Cdd:cd17473   101 GVAGIMTLA-TALIGDYFEgEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVyllALPVLILVLLFLPEPAR 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 187 DFKMPKRKFDTLGfllfgfglvmlsvsldlfgdKALPTSIPAAIVGGGFL-FLLLYVfharrikhaiiplnlfktrtfsi 265
Cdd:cd17473   179 KSKSAASPGAATA--------------------AALPWKRVLPIYFLAFLaMLLFYV----------------------- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 266 gisgniatrlgtgsIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVITVIIGLMIAQFS 345
Cdd:cd17473   216 --------------IPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 346 LQSpnmSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLavtqQLSISFGIAVSAAILnfydgQPNSNTV 425
Cdd:cd17473   282 LAS---GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV----TSAFFLGQFLSPLVL-----GPLVNLT 349

                         410       420
                  ....*....|....*....|....*
gi 2073796971 426 DNFHYTFITIGVITLVSAFVFLLLS 450
Cdd:cd17473   350 GGLSGAFLILGVLALVLAIVLLLLR 374
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 13-176 2.36e-15

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 77.42  E-value: 2.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:TIGR00710   8 LLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:TIGR00710  88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167


                  ....
gi 2073796971 173 IGVL 176
Cdd:TIGR00710 168 AGIL 171
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-449 3.88e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 76.84  E-value: 3.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:COG2223     8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:COG2223    88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 173 IGVLGVFYALKHMPDfkmpkrkfdtlgfllfgfglvmlsvsldlfgdkaLPTSIPAAivgggflflllyvfHARRIKHAI 252
Cdd:COG2223   168 LLLVVAVLAWLFLRD----------------------------------PPAGAAAA--------------AKASLRDQL 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 253 IPLNLFKTRTFSIGISGNIATRLGTGSIpflMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFV 332
Cdd:COG2223   200 EALRDPRFWLLSLLYFGTFGSFIGFSSW---LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 333 ITVIIGLMIAQFSLQSPNMSIYLLVVplFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAI 412
Cdd:COG2223   277 VFALMALGLLLLALALGSLWLFLVLF--LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2073796971 413 LNFYdgqpnsntvDNFHYTFITIGVITLVSAFVFLLL 449
Cdd:COG2223   355 LDAT---------GSYTAAFLVFAVLALVALVLTLLL 382
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-447 6.87e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 75.93  E-value: 6.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  15 AAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCAL 94
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  95 SPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTY--ATWHWIFIINIP 172
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 173 IGVLGVFYALKHMPDFKMPKRKFDTLGFLLFGFGLVMLsvsldlfgdkalptsipaaivgggflflllyvfharrikhai 252
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKR------------------------------------------ 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 253 iplnLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFV 332
Cdd:cd06174   199 ----VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 333 ITVIIglMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAI 412
Cdd:cd06174   275 IGLLL--MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2073796971 413 LnfydgqpnsNTVDNFHYTFITIGVITLVSAFVFL 447
Cdd:cd06174   353 L---------AATFGLTGAFLVLAVLLLLAAILLL 378
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 13-174 3.01e-14

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 74.15  E-value: 3.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:cd17323     2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:cd17323    82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161


                  ..
gi 2073796971 173 IG 174
Cdd:cd17323   162 IS 163
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 13-182 7.68e-14

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 72.60  E-value: 7.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFM---QALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGS 89
Cdd:cd17319     3 RIIPLLFLAyviNYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  90 LLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFII 169
Cdd:cd17319    83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162

                         170
                  ....*....|...
gi 2073796971 170 nipIGVLGVFYAL 182
Cdd:cd17319   163 ---EGLLGLLLAV 172
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
32-179 1.47e-13

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 71.87  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  32 ALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIG 111
Cdd:PRK11102   13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2073796971 112 GAMMMPVARlALIR-AYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVF 179
Cdd:PRK11102   93 AAAASVVIN-ALMRdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 27-449 2.18e-13

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 71.49  E-value: 2.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  27 TILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFIL-----AVSLFSFGSLLCALSPSLNFL 101
Cdd:cd06173    16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 102 VTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINipigvlGVFYA 181
Cdd:cd06173    96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN------ALSFL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 182 LkhmpdfkmpkrkfdtlgfllfgFGLVMLSVSLDLFGDKALPTSIPAAIVGGGFlfllLYVFHARRIKHAIIPLNLFktr 261
Cdd:cd06173   170 L----------------------SALLLLFIRRPPPAAPGESSSLLLRDLREGL----RYLRRSPLLRLLLLALALF--- 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 262 tfsigisgniatRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVITVIIGLMI 341
Cdd:cd06173   221 ------------ALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 342 AQFSLQSpnmSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAILNFYDGQPn 421
Cdd:cd06173   289 LVLGLSP---SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA- 364

                         410       420
                  ....*....|....*....|....*...
gi 2073796971 422 sntvdnfhyTFITIGVITLVSAFVFLLL 449
Cdd:cd06173   365 ---------VFLLAGALLLLAALLLLLL 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 13-189 2.46e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 71.04  E-value: 2.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:cd17324     2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIP 172
Cdd:cd17324    82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161

                         170
                  ....*....|....*..
gi 2073796971 173 IGVLGVFYALKHMPDFK 189
Cdd:cd17324   162 LALLAALLLWRLLPSLP 178
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
4-189 4.16e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 67.57  E-value: 4.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971   4 TAKNMSGLPWIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVS 83
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  84 LFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSElLPILNFVTIPGLIGPILGPLLGGILVTY--- 160
Cdd:COG0738    82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILLgls 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 2073796971 161 ATWHWIFIIN-IPIGVLGVFYALKHMPDFK 189
Cdd:COG0738   161 LSWHLPYLILaVLLLLLALLFLRSKLPEIE 190
emrD PRK11652
multidrug transporter EmrD;
27-186 5.34e-11

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 64.16  E-value: 5.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  27 TILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRV 106
Cdd:PRK11652   25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 107 IQGIG----GAMMMPVARlaliRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYAL 182
Cdd:PRK11652  105 IQGLGtgvgGVMARTLPR----DLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMA 180


                  ....
gi 2073796971 183 KHMP 186
Cdd:PRK11652  181 RWMP 184
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 14-187 1.84e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 62.37  E-value: 1.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCA 93
Cdd:TIGR00895  21 LSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  94 LSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPI 173
Cdd:TIGR00895 101 LATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIA 180

                         170
                  ....*....|....
gi 2073796971 174 GVLGVFYALKHMPD 187
Cdd:TIGR00895 181 PLLLLLLLMRFLPE 194
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 14-179 5.61e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 60.69  E-value: 5.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIP--ISGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:cd17316     3 LAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGalLFGYLGDRIGRKKALILTLLLFGLATLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  92 CALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYAT----WHWIF 167
Cdd:cd17316    83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILF 162

                         170
                  ....*....|..
gi 2073796971 168 IINIPIGVLGVF 179
Cdd:cd17316   163 LIGALPALLALL 174
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
31-176 1.26e-09

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 60.04  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  31 TALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGI 110
Cdd:PRK10473   24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 111 GGAMMMPVArLALIR----AYPRSELLPILNFVTIpglIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:PRK10473  104 GAGCCYVVA-FAILRdtldDRRRAKVLSLLNGITC---IIPVLAPVLGHLIMLKFPWQSLFYTMAAMGIL 169
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 17-182 2.10e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 59.14  E-value: 2.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  17 MAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSP 96
Cdd:cd17489     3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  97 SLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:cd17489    83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162


                  ....*.
gi 2073796971 177 GVFYAL 182
Cdd:cd17489   163 ALLLVF 168
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 14-111 6.22e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 57.58  E-value: 6.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCA 93
Cdd:cd17359     5 VAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84

                          90
                  ....*....|....*...
gi 2073796971  94 LSPSLNFLVTSRVIQGIG 111
Cdd:cd17359    85 FSPNFTIFIIARIIGGLA 102
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 16-182 7.49e-09

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 57.18  E-value: 7.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQALDATILNTALPDIAK----SLHHSPLAMQSAVVSYTLTVAllipISGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:cd17380     5 FLATCICYADRVNMPIAIVPMAKefgwSKTDQGLVLSSFFWGYALTQV----LGGYLADRFGGKKVLLLAVALWSLATLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  92 C--ALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFII 169
Cdd:cd17380    81 TplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160

                         170
                  ....*....|...
gi 2073796971 170 nipIGVLGVFYAL 182
Cdd:cd17380   161 ---FGLLGLLWAL 170
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 16-169 2.00e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 56.05  E-value: 2.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQAL---DATILNTALPDIAKSLHHSPlAMQSAVVSYTLtVALLIP--ISGWFADRFGTRRIFILAVSLFSFGSL 90
Cdd:cd17365     2 ALCFLIIVLdgfDLAVMGFVAPALAQDWGLSP-AQLGPVGSAAL-FGMAIGalLAGPLADRFGRKRVLLVSVALFGLFTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  91 LCALSPSLNFLVTSRVIQGIGGAMMMPVArLALIRAYPRSELLPILNFVTIPGL-IGPILGPLLGGILVTYATWHWIFII 169
Cdd:cd17365    80 LTAFAQSVLQLALLRFLTGLGLGAAMPNA-ITLVSEYAPARRRSLAVTLMFCGYpLGAALGGFLAAALIPAFGWRSVFLL 158
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 14-111 2.96e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 55.27  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLH-HSPLAMQSAVVSYTLTVALLIPI-SGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:cd17315     1 VAALGGLLFGYDLGVINGALLYIAKDLGfGLSTSLQGLVVSSLLLGAAIGSLfGGPLADRFGRRKSLLIAAVLYVIGALL 80

                          90       100
                  ....*....|....*....|
gi 2073796971  92 CALSPSLNFLVTSRVIQGIG 111
Cdd:cd17315    81 SALAPNVWVLIVGRFLLGLG 100
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 13-182 9.78e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 9.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVS-YTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:cd17325   202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGaQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  92 CALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINI 171
Cdd:cd17325   282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361

                         170
                  ....*....|.
gi 2073796971 172 PIGVLGVFYAL 182
Cdd:cd17325   362 ALLLLAAVLFL 372
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
60-186 1.03e-07

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 53.79  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  60 LLIPISgwfaDRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFV 139
Cdd:PRK15402   67 LLGPLS----DRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALM 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2073796971 140 TIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALKHMP 186
Cdd:PRK15402  143 ANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMP 189
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 13-182 3.24e-07

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 52.78  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAmQSAVVSYTLtvallipISGWF--------ADRFGTRRIFILAVSL 84
Cdd:PRK03893   23 SAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQ-AASLISAAF-------ISRWFgglllgamGDRYGRRLAMVISIVL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  85 FSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWH 164
Cdd:PRK03893   95 FSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWR 174

                         170
                  ....*....|....*...
gi 2073796971 165 WIFIinipIGVLGVFYAL 182
Cdd:PRK03893  175 ALFF----IGILPIIFAL 188
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 13-176 3.45e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 52.24  E-value: 3.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSP----LAMQSAVVSYTLtvalLIPISGWFADRFGTRRIFILAVSLFSFG 88
Cdd:cd17328     2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDslagLLQTVFIISYMV----LSPIFGYLGDRYNRKWILAVGILIWSAA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  89 SLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYA-TWHWIF 167
Cdd:cd17328    78 TLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAF 157


                  ....*....
gi 2073796971 168 IINIPIGVL 176
Cdd:cd17328   158 RVTGVLGVL 166
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 50-160 3.74e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 52.23  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  50 AVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPR 129
Cdd:cd17329    40 VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP 119

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2073796971 130 SELLPILNFVTIPGLIGPILGPLLGGILVTY 160
Cdd:cd17329   120 ENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 14-118 5.72e-07

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 51.50  E-value: 5.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPLA--MQSAVVSYTLTVALLIP-ISGWFADRFGTRRIFILAVSLFSFGSL 90
Cdd:cd17360     1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLStgWQELIVSSTVAGAAVGAaIGGWLNDRFGRRPCILLADALFTIGAI 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2073796971  91 LCALSPSLNFLVTSRVIQGIG---GAMMMPV 118
Cdd:cd17360    81 VMAAAPNKEVLIVGRVLVGLGvgiASMTVPL 111
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 17-187 5.98e-07

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 51.57  E-value: 5.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  17 MAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSP 96
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  97 SLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILN-FVTIPGLIGPILGPLLGGILVTYaTWHWIFIINIPIGV 175
Cdd:TIGR00893  81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSiFNSAQGLGGIIGGPLVGWILIHF-SWQWAFIIEGVLGI 159

                         170
                  ....*....|..
gi 2073796971 176 LGVFYALKHMPD 187
Cdd:TIGR00893 160 IWGVLWLKFIPD 171
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
9-182 8.31e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.03  E-value: 8.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971   9 SGLPWIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFG 88
Cdd:COG2807   214 SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  89 SLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILN-FVTIPGLIGPILGPLLGGILVTYA-TWHWI 166
Cdd:COG2807   294 GLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSgMAQSVGYLLAALGPLLVGALHDATgSWTAA 373

                         170
                  ....*....|....*.
gi 2073796971 167 FIINIPIGVLGVFYAL 182
Cdd:COG2807   374 LLLLAALAVLMLVAGL 389
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
70-194 1.82e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 49.89  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  70 DRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIgGAMMMPVARLAL-IRAYPRSELLPIlnFVTIPGLIG-- 146
Cdd:PRK11043   66 DRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAV-GVCSAAVIWQALvIDRYPAQKANRV--FATIMPLVAls 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2073796971 147 PILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALKHMPDFKMPKRK 194
Cdd:PRK11043  143 PALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQS 190
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
60-187 1.95e-06

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 49.82  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  60 LLIPISgwfaDRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFV 139
Cdd:PRK15403   70 LLGPLS----DRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAII 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2073796971 140 TIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALKHMPD 187
Cdd:PRK15403  146 TSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPE 193
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 13-413 2.12e-06

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 50.13  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMA----FFMQALDATILNTalpdiakSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFG 88
Cdd:pfam05977  16 WIASLAsnlgTLMQDVAASWLMT-------SLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  89 SLLCALSPSLNFLVTSRVI-----QGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATW 163
Cdd:pfam05977  89 STLLTLLAGLGLLSPWLLLgltflGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 164 HWIFIINIpIGVLGVFYALKHMPdfkmpkrkfdtlgfllfgfglvmlsvsldlfgDKALPTSIPAAIVGGGFLFLLLYVF 243
Cdd:pfam05977 169 AFTFALNA-LSYFAVIAALWRWK--------------------------------RAAPASPLPRERIFGAVRAGLRFTA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 244 HARRIKHAIIplnlfktRTFSIGisgniatrLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTK 323
Cdd:pfam05977 216 MSRELRSVLV-------RAFAFG--------LSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRER 280

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 324 YGYRNTLFVITVIIGLMIAQFSLQSPnmsIYLLVVPLFILGMVMSVQFTAMNTICLADLTD--------------NNASA 389
Cdd:pfam05977 281 LGSDRLVLLASVVTALVLLSLALAPN---LWLAIPVLLLGGAAWITALTTLNVAVQLSVPRwvrgralavyqtvfFGGMA 357

                         410       420
                  ....*....|....*....|....*.
gi 2073796971 390 GNSML--AVTQQLSISFGIAVSAAIL 413
Cdd:pfam05977 358 AGSWLwgAVAEALSVTGALLGAAAAL 383
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 51-176 3.98e-06

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 48.89  E-value: 3.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  51 VVSYTLTVALLIPISGWF-ADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQG--IGGAMMMPVARLALIRAY 127
Cdd:cd17362    44 VVSGSLLGALLGSLVAGAlIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGvgIGLAMHAAPVYIAETSPS 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2073796971 128 PRSELLPILN--FVTIPGLIGPILGPLLGGilvTYATWHWIFIINIPIGVL 176
Cdd:cd17362   124 HIRGLLVSLKelFIVLGILLGYVSGYAFAD---VVGGWRYMYGLAAPPALL 171
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 21-119 4.65e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 48.81  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  21 MQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNF 100
Cdd:PRK11551   26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105

                          90       100
                  ....*....|....*....|.
gi 2073796971 101 LVTSRVIQGI--GGAMMMPVA 119
Cdd:PRK11551  106 LLVARLLTGVglGGALPNLIA 126
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 28-214 4.65e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 48.71  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  28 ILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVI 107
Cdd:cd17478    14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 108 QGIGGAMMMPVArLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALKHMPD 187
Cdd:cd17478    94 AGIGSAAFHPEG-ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172

                         170       180
                  ....*....|....*....|....*..
gi 2073796971 188 FKMPKRKFDTLGFLLFGFGLVMLSVSL 214
Cdd:cd17478   173 KKPEAKKAAAKSSARSTLKGVWRALLL 199
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 14-263 5.04e-06

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 48.90  E-value: 5.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQAlDATILNTALPDIAKSLHHSPLAmqsavVSYTLTVALLIPISGWFADRFGtRRIFILAVSLFSF-GSLLC 92
Cdd:pfam06609  53 VCATYFVLQA-SASALPNILQDIGQSENQGLFS-----TLWTMGQAVSILMMGRLTDRFG-RRPFVIATHIIGLvGAIVG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  93 ALSPSLNFLVTSRVIQGI--GGAMMMPVARLALIRAypRSELLPILnFVTIPGLIGPILGPLLGGILVTYATWHWIFIIN 170
Cdd:pfam06609 126 CTANKFNTLLAAMTLLGVaaGPAGASPLFIGELMSN--KTKFLGLL-IVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIY 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 171 IPIGVLGVFYAL--KHMPDF-----KMPKRKFDTLGFLLFGFGLVMLSVSLDLFGDK--ALPTSI--PAAIVG------G 233
Cdd:pfam06609 203 IIMSAIAVLLIIiwYHPPSFaqlhgKKARKRDELAKLDWIGIFLVIAGTSLFLLGVSwgGKPNNPwnSAKIIGlissgaG 282

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2073796971 234 GFLFLLLYVFHARRIKhAIIPLNLFK-TRTF 263
Cdd:pfam06609 283 SLVIFALYEVFGKPEQ-PIIPPALFKdTRGF 312
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 29-187 5.45e-06

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 48.53  E-value: 5.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  29 LNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQ 108
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 109 GIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVT-YATWHWIFIINIPIGVLGVFYALKHMPD 187
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAIIVSLICFLLLRD 173
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 13-187 9.85e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.68  E-value: 9.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPlAMQSAVVSYTLTVALLIPI-SGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:cd17371     2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDE-AEAGLLGTVTLAGGAIGGIlGGILADRFGRVRVLVITILLFAVFTLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  92 CALSPSLNFLVTSRVIQGIG-------GAMMMPvarlALIRAYPRSELLPILN-FVTIPGLIGPILGPLLGGILVTYATW 163
Cdd:cd17371    81 CGFAQNYWQLLILRALAGLGfggewaaGAALMA----EYVPARHRGKALGYVQsGWAVGWLLATLLAALLFPLLPPEIAW 156

                         170       180
                  ....*....|....*....|....
gi 2073796971 164 HWIFIINIpIGVLGVFYALKHMPD 187
Cdd:cd17371   157 RVLFLLGA-LPALLVLFIRRFVKE 179
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
 13-157 1.04e-05

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 47.37  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:pfam06779 196 WILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLS 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2073796971  93 ALSPSLNFLVTSRViqGIGGAMMMPVAR-LALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGIL 157
Cdd:pfam06779 276 LLSPSPAGLAVSSL--LFGGTFMAITSLvMQLARELAPPAPRRLLGLMTASFGIGQILGPLLASLL 339
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 37-186 1.55e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.80  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  37 AKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAmMM 116
Cdd:cd17330    26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NV 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2073796971 117 PVARLALirAYPRSELLPILNFVTIPGL--IGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALKHMP 186
Cdd:cd17330   105 SVAQAYI--ADITDEEERAKAFGIISAAfgLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 13-164 2.97e-05

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 46.10  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:cd17393     2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2073796971  93 ALSPSLNFLVTSRVIQGIGGAMM---MPVARLALIRAYPRsellPILNFVTIPGLIGPILGPLLGGILV---TYATWH 164
Cdd:cd17393    82 GLAPSVPALALALFLFGAANGALdvaMNAQGVAVERAYGR----PIMSSLHAMWSLGGLAGALLGAAAIgagVSPGVH 155
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 37-187 3.08e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 46.05  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  37 AKSLHH-SPLAMQSAVVSYTLTVALL-IPIsGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIgGAM 114
Cdd:cd17472    23 AKSLPGaTPTLIGLALGIYGLTQAIFqIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 115 MMPVarLALIRAYPRSE-------LLPILNFVTIpgLIGPILGPLLGGILvtyaTWHWIFIINIPIGVLGVFYALKHMPD 187
Cdd:cd17472   101 SSVV--MALLADLTREEnrtkamaLIGASIGIAF--AISMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLFFVPD 172
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 65-176 3.83e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 45.69  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  65 SGWFADRFGTRRIFILAVSLfsfGSLLCALSP-----SLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFV 139
Cdd:cd17318    76 GGYLAEKYGAKRVLGYSILI---TALLTLLTPlaargGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2073796971 140 TIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVL 176
Cdd:cd17318   153 YSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLL 189
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 11-187 4.46e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 45.70  E-value: 4.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  11 LPWIAaMAFFMQALD-ATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGS 89
Cdd:cd17327     7 LPLLC-ILYFLQYLDkSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  90 LLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLG-GILV-----TYATW 163
Cdd:cd17327    86 LLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvgGLAGW 165

                         170       180
                  ....*....|....*....|....
gi 2073796971 164 HWIFIINIPIGVLGVFYALKHMPD 187
Cdd:cd17327   166 RWLFIIEGLITIIIGLVIFFWLPD 189
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 50-119 4.99e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 45.26  E-value: 4.99e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  50 AVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVA 119
Cdd:cd17317    30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG 99
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 12-169 6.51e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.95  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  12 PWIAAMAFFMQALDATILNTA---LPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFG 88
Cdd:cd17355     2 WVVLAVTFLILILSWGIRYYFgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  89 SLLCALSPSL-NFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIF 167
Cdd:cd17355    82 LVLLALATSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161


                  ..
gi 2073796971 168 II 169
Cdd:cd17355   162 LV 163
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 29-187 6.89e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.96  E-value: 6.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  29 LNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQ 108
Cdd:cd17312    22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2073796971 109 GIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALKHMPD 187
Cdd:cd17312   102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD 180
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
33-129 7.16e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 7.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  33 LPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGG 112
Cdd:COG2807    41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120

                          90
                  ....*....|....*..
gi 2073796971 113 AMMMPVARLALIRAYPR 129
Cdd:COG2807   121 AVGNVLLPGLIKRWFPD 137
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 31-179 7.17e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  31 TALPDIAK-SLHHSPLAMQSAVVSYTLTVALLIPISG-WFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQ 108
Cdd:cd17474   219 TYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLF 298

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2073796971 109 GIGGAMMMPVARLALIRAYP---RSELLPILNFVtipGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVF 179
Cdd:cd17474   299 GLGLGLNLPLLTTLVTELAPeeeRGTASSLYNFV---RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 13-157 7.48e-05

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 44.99  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLC 92
Cdd:cd06180   199 WRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLP 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2073796971  93 ALSPSLNFLVTSRVIQGiGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGIL 157
Cdd:cd06180   279 LLSPGPAGLVLSAVLFG-GTFMAITALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGWL 342
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 33-177 7.52e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 44.90  E-value: 7.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  33 LPDIAKSLHHSPLAMQSAVVSYTLTVALL-IPIsGWFADRFGTRRIFILAVSLFS-FGSLLCALSPSLNFLVTSRVIQGI 110
Cdd:cd17490    19 LSPYAESLGASLSMIGIILGAYGISQMLLrIPL-GILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGI 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2073796971 111 GGAMMMpVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINIPIGVLG 177
Cdd:cd17490    98 AAATWV-SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLG 163
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 63-188 1.52e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 43.75  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  63 PISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMpVARLALIRAYPRSELLPILNFVTIP 142
Cdd:cd17390    49 PLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQS-LCKAYLSDLVSEQERSRVLGRFNAA 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2073796971 143 GLIGPILGPLLGGILVTY--------ATWHWIFIINipigVLGVFYALKHMPDF 188
Cdd:cd17390   128 SSLGFILGPVVGGHLAETdggfyyvaLLCSAIFILN----AGLVWFLLSKLWDL 177
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 16-376 1.87e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 43.75  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  16 AMAFFMQaldatilNTALPDIAKSLhhsplAMQSAVVSYTLTVALLI-----PISGWFADRFGTRRIFILAVSLFSFGSL 90
Cdd:cd17331    13 ATCYWLQ-------QPVLPYLTKKL-----GVDSVVFGYLQTTFSVLqlvggPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  91 LCALSPSLNFLVTSRviqgIGGAMM--MPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFI 168
Cdd:cd17331    81 LLAFASSVPMLFLSR----LPSVFMhaMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAAL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 169 INIPIGVLGVFYALKHMPDFKMPKRKfdtlgfllfgfglvmlsvsldlfGDKALPTSIPAAIVGGGFLFLLlyvfharrI 248
Cdd:cd17331   157 VAAVGSLLSIVLVILLIPSNTKSKRE-----------------------KEAKESASPPSVFNLKEILRLL--------R 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 249 KHAIIPLNLFKTrtfsigISGniatrLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTK-YGYR 327
Cdd:cd17331   206 LPGVAFLLLVKL------LSG-----LPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKrFGER 274

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2073796971 328 NTLFVITVIIGLMIAQFSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNT 376
Cdd:cd17331   275 SLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLT 323
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 14-111 1.95e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 43.42  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPIS-----GWFADRFGTRRIFILAVSLFSFG 88
Cdd:cd17364     3 IAGMGFFTDAYDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAALVGTIIgqlffGFLGDRFGRKRVYGVELIIMIIG 82

                          90       100
                  ....*....|....*....|....*....
gi 2073796971  89 SLLCALSPS---LNFLVT---SRVIQGIG 111
Cdd:cd17364    83 TILSALSPGstpLGVMGWlifFRFLLGIG 111
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-119 4.21e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAV-VSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:COG2211   231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLlALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                          90       100       110
                  ....*....|....*....|....*....|
gi 2073796971  92 CALSPSLNF--LVTSRVIQGIGGAMMMPVA 119
Cdd:COG2211   311 LFFLGPGNLwlLLVLAALAGIGLGAILVLP 340
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 66-110 5.15e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 42.28  E-value: 5.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2073796971  66 GWFADRFGTRRIFILAVSLFSFGSLLCALSPSLN--------FLVTSRVIQGI 110
Cdd:cd17367    61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGL 113
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 265-449 6.56e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.83  E-value: 6.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 265 IGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVITVIIGLMIAQF 344
Cdd:cd17329     3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 345 SLQspnMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAILNFydgqpnsnt 424
Cdd:cd17329    83 GFA---HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY--------- 150

                         170       180
                  ....*....|....*....|....*
gi 2073796971 425 vdNFHYTFITIGVITLVSAFVFLLL 449
Cdd:cd17329   151 --SFRLLFLAAAVLFLLAALVLLFL 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-182 8.37e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 8.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971   1 MFKTAKNMSGLPWIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFIL 80
Cdd:cd17324   190 SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  81 AVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIpGLIGPILGPLLGGILVTY 160
Cdd:cd17324   270 LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAA-YNLGGALGAALGGLVLDH 348

                         170       180
                  ....*....|....*....|..
gi 2073796971 161 ATWHWIFIINIPIGVLGVFYAL 182
Cdd:cd17324   349 GGWAGVGWVGAALLLLALLLAL 370
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 33-187 9.36e-04

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 41.23  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  33 LPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGG 112
Cdd:PRK10091   26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2073796971 113 AMMMPVARLALIRAYPR---SELLPIL-NFVTIPGLIGPILGPLLGGILvtyaTWHWIFIINIPIGVLGVFYALKHMPD 187
Cdd:PRK10091  106 GAFFGVGAIVLSKIIKPgkvTAAVAGMvSGMTVANLLGIPLGTYLSQEF----SWRYTFLLIAVFNIAVLASIYFWVPD 180
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 20-406 1.03e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  20 FMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLN 99
Cdd:cd17477     6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 100 FLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYAtwhwifiiNIPIGVLGVF 179
Cdd:cd17477    86 VWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG--------ALPFLIAAVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 180 YALkhmpdfkmpkrkfdtlgfllfgfglvmlSVSLDLFGDKALPTSIPAAIVGGGFLFLllyvfharrikhaIIPLnlfk 259
Cdd:cd17477   158 LLL----------------------------ALVPLLLTRRAAPEIEEAESISLRRLLR-------------IAPL---- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 260 trtfsiGISGNIATRLGTGSIPFLMPLMLqVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVITVIIGL 339
Cdd:cd17477   193 ------ALLGAFVAGFLEGAFYSLLPLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGAL 265

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2073796971 340 MIAQFSLQSPNMsiYLLVVPLFILGMVMsvqfTAMNTICLADLTDNnaSAGNSMLAVTQQLSISFGI 406
Cdd:cd17477   266 AALLLPLVPGLP--LALLVLLFLWGGAA----GPLYTLALALAGDR--LPGDELVAANAALLLLYGL 324
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 13-178 1.22e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.15  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAkslhHSPLAMQSAVVSYTLTVALLIPI-SGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:cd17333     2 YISFFSNGLTDALLGILGPSLEEAF----NLNVADVSVIFSSQNAGYLIGSLlAGFLMKRLGRRRTLILGLLLISLALAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  92 CALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSeLLPILNFVTIPGLIGPILGPLLGGILVT-YATWHWIFIIN 170
Cdd:cd17333    78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLII 156


                  ....*...
gi 2073796971 171 IPIGVLGV 178
Cdd:cd17333   157 GLIYLLLA 164
Sugar_tr pfam00083
Sugar (and other) transporter;
14-111 1.32e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.10  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  14 IAAMAFFMQALDATILNTALPDIAKSLHHSPL----AMQSAVVSYTLTVALLIP-------ISGWFADRFGTRRIFILAV 82
Cdd:pfam00083   4 VAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSksvsSLAALSVLSGLIVSIFSVgcfigslFAGKLGDRFGRKKSLLIAN 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2073796971  83 SLFSFGSLLCALSPSLNF---LVTSRVIQGIG 111
Cdd:pfam00083  84 VLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIG 115
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-451 1.76e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.66  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDI-AKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADR----FGTRRIFILAVS-LFS 86
Cdd:COG2211    13 LAYGLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRtrtrWGRRRPWILIGAiPLA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  87 FGSLLCALSPSLN-------FLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVT 159
Cdd:COG2211    93 LSFVLLFTAPDLSptgkliyALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 160 YatwhwiFIINIPIGVLGVFYALkhmpdfkmpkrkfdtlgfllfgfglvmlsvsldlfgdkalptsipAAIVGGGFLFLL 239
Cdd:COG2211   173 A------FGGDAALGYRLTALIF---------------------------------------------AVLGLLAFLLTF 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 240 LYVFHARRIKHAIIPL-----NLFKTRTFSIGISGNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAK 314
Cdd:COG2211   202 FGTKERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 315 SGVTKILTKYGYRNTLFVITVIIGLMIAQFSLqSPNMSIYLLVVPLFILGMVMSVQFTAMNTIcLADLTD--------NN 386
Cdd:COG2211   282 PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWAM-LADVVDydewktgrRR 359

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2073796971 387 ASAGNSMLAVTQQLSISFGIAVSAAILNFYDGQPNS----NTVDNFHYTFITIGVITLVSAFVFLLLSK 451
Cdd:COG2211   360 EGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAaqspSALTGIRLLFFLLPAVLLLLAALLLLFYP 428
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 34-169 1.91e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 40.47  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  34 PDIAKSLHHSPLAMQSAVVSYTLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTS-RVIQGIGG 112
Cdd:cd17314    27 QPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYAcFVFIGAGT 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2073796971 113 AMMMPVARLALIRAYPRSELLPiLNFVTIPGLIGPILGPLLGGILVTYATWHWIFII 169
Cdd:cd17314   107 GILYGSAVLVTTQYFPDTKGLA-LGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTI 162
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 13-186 2.35e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.95  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPlaMQSAVVSYTLTVALLI--PISGWFADRFGTRRIF--ILAVSLFSFG 88
Cdd:cd17355   213 WLLALAFFLCGFAVVGLIVHLVPYLADRGISP--AAAAVALALIGLFNIVgrLLSGWLGDRYSPRRLLaaSYALRALGLA 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  89 SLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLAlIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYA-TWHWIF 167
Cdd:cd17355   291 LLLLLPFPPLALLLFAALFGLGWGATVPLTAALA-ARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAW 369

                         170
                  ....*....|....*....
gi 2073796971 168 IInipIGVLGVFYALKHMP 186
Cdd:cd17355   370 AL---AVALGLIAALLVLP 385
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 64-183 3.27e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.48  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  64 ISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELLPILNFVTIPG 143
Cdd:cd17330   230 LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ 309

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2073796971 144 LIGPILGPLLGGILVTYATWHWIFIINIPIGVLGVFYALK 183
Cdd:cd17330   310 SLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 42-412 4.68e-03

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 39.21  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  42 HSPLAMQSAVVSytLTVALLIPISGWFADRFGTRRIFILAVSLFSFGSLLCALSPSLNFLVTSRVIQGIGGAMMMPVARL 121
Cdd:cd17322    36 HSLLSTINVVNN--IVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 122 ALIRAYPRSELLPILNFVTIPGLIGPILGPLLGGILVTYATWHW---IFIINIPIGVLGVFYALKHM-------PDFKMP 191
Cdd:cd17322   114 ILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWgygMWAIILPLSSLPLVLCLLYMqrkarkdGEIKEL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 192 KRKFDTLGFLLFGFGLVMLSVSLDLFG----------------------DKALPTSIPAAIVGGGFLFLLLYVFHARRIK 249
Cdd:cd17322   194 KNQETEEQTGGLSQNLVKLFWKLDIFGvilltaglglilvpltlaggakSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAK 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 250 HAIIPLNLFKTRTFsIGISGNIATRLGTGSIpFLMPL--MLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYR 327
Cdd:cd17322   274 YPFLPFRLLKDRTI-LAACLIDFFYFFSYYI-FSDYLytVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRY 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 328 NTLFVITVII-----GLMIaqfSLQSPNMSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSI 402
Cdd:cd17322   352 KVLVIIGVPLyivgmGLLI---RYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGG 428

                         410
                  ....*....|
gi 2073796971 403 SFGIAVSAAI 412
Cdd:cd17322   429 AVGAAISGAI 438
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-183 5.90e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  13 WIAAMAFFMQALDATILNTALPDIAKSLHHSPLAMQSAVVSYTLTVALLI-PISGWFADRFGTRRIFILAVSLFSFGSLL 91
Cdd:COG0738   213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGrFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971  92 CALSPSLNFLVTSRVIQGIGGAMMMPVARLALIRAYPRSELlPILNFVTIPGLIGPILGPLLGGILVTYATWHWIFIINI 171
Cdd:COG0738   293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTA-AAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPL 371

                         170
                  ....*....|..
gi 2073796971 172 PIGVLGVFYALK 183
Cdd:COG0738   372 VCYLLILLLALA 383
MFS_1 pfam07690
Major Facilitator Superfamily;
269-449 6.00e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 269 GNIATRLGTGSIPFLMPLMLQVGFGYEAVVAGMMMAPLAIGSITAKSGVTKILTKYGYRNTLFVITVIIGLMIAQFSLQS 348
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073796971 349 pnmSIYLLVVPLFILGMVMSVQFTAMNTICLADLTDNNASAGNSMLAVTQQLSISFGIAVSAAILNFYdgqpnsntvdNF 428
Cdd:pfam07690  84 ---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----------GW 150

                         170       180
                  ....*....|....*....|.
gi 2073796971 429 HYTFITIGVITLVSAFVFLLL 449
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLP 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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