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Conserved domains on  [gi|2073902719|ref|WP_219335986|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Chroococcidiopsis]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HTH_CRP super family cl46859
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
25-64 4.25e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


The actual alignment was detected with superfamily member cd00569:

Pssm-ID: 481199 [Multi-domain]  Cd Length: 42  Bit Score: 37.30  E-value: 4.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2073902719  25 KKLTEADRTEILDLYRNtGETTSTLADRYGVSNSTISRFL 64
Cdd:cd00569     4 PKLTPEQIAEARRLLAA-GESVAEIARELGVSRSTLYRYL 42
 
Name Accession Description Interval E-value
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
25-64 4.25e-04

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 37.30  E-value: 4.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2073902719  25 KKLTEADRTEILDLYRNtGETTSTLADRYGVSNSTISRFL 64
Cdd:cd00569     4 PKLTPEQIAEARRLLAA-GESVAEIARELGVSRSTLYRYL 42
HTH_38 pfam13936
Helix-turn-helix domain; This helix-turn-helix domain is often found in transferases and is ...
25-65 5.91e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.


Pssm-ID: 433591 [Multi-domain]  Cd Length: 44  Bit Score: 34.41  E-value: 5.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2073902719  25 KKLTEADRTEILDLYRNtGETTSTLADRYGVSNSTISRFLK 65
Cdd:pfam13936   3 KHLSLEEREEIARLLAE-GLSLREIARRLGRSPSTISRELR 42
 
Name Accession Description Interval E-value
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
25-64 4.25e-04

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 37.30  E-value: 4.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2073902719  25 KKLTEADRTEILDLYRNtGETTSTLADRYGVSNSTISRFL 64
Cdd:cd00569     4 PKLTPEQIAEARRLLAA-GESVAEIARELGVSRSTLYRYL 42
HTH_38 pfam13936
Helix-turn-helix domain; This helix-turn-helix domain is often found in transferases and is ...
25-65 5.91e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.


Pssm-ID: 433591 [Multi-domain]  Cd Length: 44  Bit Score: 34.41  E-value: 5.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2073902719  25 KKLTEADRTEILDLYRNtGETTSTLADRYGVSNSTISRFLK 65
Cdd:pfam13936   3 KHLSLEEREEIARLLAE-GLSLREIARRLGRSPSTISRELR 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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