|
Name |
Accession |
Description |
Interval |
E-value |
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
146-365 |
2.14e-51 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 171.73 E-value: 2.14e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 146 LALLEAIAFQIGTTIQRIQLVEKERKYVVVAERNRLARDLHDSVKQLLFSIMLTAKGTLNMTQDR--GLQEMLSYIGELS 223
Cdd:COG4585 22 LALVLLRARRAERAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDADpeAAREELEEIRELA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 224 QEALQEMTLLIWQLRPEGLEK-GLAEAIQNY----GKLLGVQVEVRIDGM-VSIGDEIEEVLWRISQEALHNCKKHASCE 297
Cdd:COG4585 102 REALAELRRLVRGLRPPALDDlGLAAALEELaerlLRAAGIRVELDVDGDpDRLPPEVELALYRIVQEALTNALKHAGAT 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080646197 298 KVHVLLKIENNQLHFYIEDNGIGFIQEQVRGSALGLKSMKERIQLMKGSFQITTELKKGTKIEIQLPI 365
Cdd:COG4585 182 RVTVTLEVDDGELTLTVRDDGVGFDPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
279-364 |
4.83e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 88.76 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 279 LWRISQEALHNCKKHASCEKVHVLLKIENNQLHFYIEDNGIGFIQEQV-RGSALGLKSMKERIQLMKGSFQITTELKKGT 357
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPpGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80
|
....*..
gi 2080646197 358 KIEIQLP 364
Cdd:cd16917 81 RVTARLP 87
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
130-364 |
4.55e-17 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 82.33 E-value: 4.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 130 LLNVAAPHKTHFSEEELA-LLEAIAFQ------IGTTIQR---------IQLVEKER--KYVVVAE---RNRLARDLHDS 188
Cdd:PRK11644 233 LLNAIALIASQTWHDHPVdLLLSLLAQsltgllLGAGIQRqrelnqslqKELARNRHlaERLLETEesvRRDVARELHDE 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 189 VKQLLFSIMlTAKGTLNM--TQDRGLQEMLSYIGELSQEALQEMTLLIWQLRPEGLEK-GLAEAIQNYGKLLGVQ---VE 262
Cdd:PRK11644 313 IGQTITAIR-TQAGIIKRlaADNASVKQSAQLIEQLSLGVYDTVRRLLGRLRPRQLDDlTLEQAIRSLMREMELEdrgIV 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 263 VRIDGMV--SIGDEIEEV-LWRISQEALHNCKKHASCEKVHVLLKIENNQLHFYIEDNGIGF-IQEQVRGsaLGLKSMKE 338
Cdd:PRK11644 392 SHLDWRIdeSALSETQRVtLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLpPGSGQQG--FGLRGMRE 469
|
250 260
....*....|....*....|....*.
gi 2080646197 339 RIQLMKGSFQITTElkKGTKIEIQLP 364
Cdd:PRK11644 470 RVTALGGTLTISCT--HGTRLSVSLP 493
|
|
| GAF |
COG2203 |
GAF domain [Signal transduction mechanisms]; |
1-287 |
8.99e-15 |
|
GAF domain [Signal transduction mechanisms];
Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 75.62 E-value: 8.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 1 MHRLEALKEIAELLNEATNLQDMLEKVLHTLLQVMNLQTGWIFFIDESGKHRMLVdenLPPALTWQEKKPMCEGDCWCVE 80
Cdd:COG2203 189 LERLALLNEISQALRSALDLEELLQRILELAGELLGADRGAILLVDEDGGELELV---AAPGLPEEELGRLPLGEGLAGR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 81 RFVNGRLEKATNIIECKRIEDAIECNWGEtEDVTHHATIPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTI 160
Cdd:COG2203 266 ALRTGEPVVVNDASTDPRFAPSLRELLLA-LGIRSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQAAIAI 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 161 QRIQLVEKERKyvvvAERNRLARDLHDSVKQLLFSIMLTAKGTLNMTQDRGLQEMLSYIGELSQEALQEMTLLIWQLRPE 240
Cdd:COG2203 345 ERARLYEALEA----ALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALEG 420
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2080646197 241 GLEKGLAEAIQNYGKLLGVQVEVRIDGMVSIGDEIEEVLWRISQEAL 287
Cdd:COG2203 421 LLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEI 467
|
|
| HisKA_3 |
pfam07730 |
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ... |
177-242 |
2.42e-14 |
|
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.
Pssm-ID: 429624 [Multi-domain] Cd Length: 68 Bit Score: 67.26 E-value: 2.42e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080646197 177 ERNRLARDLHDSVKQLLFSIMLTAKGTLNMTQDR--GLQEMLSYIGELSQEALQEMTLLIWQLRPEGL 242
Cdd:pfam07730 1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDpeEAREQLDAIRELAREALQELRRLLGDLRPPAL 68
|
|
| GAF_2 |
pfam13185 |
GAF domain; The GAF domain is named after some of the proteins it is found in, including ... |
17-161 |
7.88e-13 |
|
GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433019 [Multi-domain] Cd Length: 137 Bit Score: 65.18 E-value: 7.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 17 ATNLQDMLEKVLHTLLQVMNLQTGWIFFIDESGkhRMLVDENLPPALTWQEKKPMCEGDCWcvERFVNGRLEKATNIIEC 96
Cdd:pfam13185 1 AADLEELLDAVLEAAVELGASAVGFILLVDDDG--RLAAWGGAADELSAALDDPPGEGLVG--EALRTGRPVIVNDLAAD 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080646197 97 KRIEDAIEcnwgETEDVTHHATIPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTIQ 161
Cdd:pfam13185 77 PAKKGLPA----GHAGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAIE 137
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
272-365 |
8.96e-13 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 64.21 E-value: 8.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 272 GDEIEevLWRISQEALHNCKKHA-SCEKVHVLLKIENNQLHFYIEDNGIGFIQEQV-----------------RGSALGL 333
Cdd:smart00387 1 GDPDR--LRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVEITVEDNGPGIPPEDLekifepffrtdkrsrkiGGTGLGL 78
|
90 100 110
....*....|....*....|....*....|..
gi 2080646197 334 KSMKERIQLMKGSFQITTELKKGTKIEIQLPI 365
Cdd:smart00387 79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| GAF |
smart00065 |
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ... |
19-170 |
1.19e-06 |
|
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.
Pssm-ID: 214500 [Multi-domain] Cd Length: 149 Bit Score: 47.76 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 19 NLQDMLEKVLHTLLQVMNLQTGWIFFIDESgkhrmlvDENLPPALTWQEKKPMCEGDCWCVERFVNGRlekatnIIECKR 98
Cdd:smart00065 1 DLEELLQTILEELRQLLGADRVLIYLVDEN-------DRGELVLVAADGLTLPTLGIRFPLDEGLAGR------VAETGR 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 99 ---IEDAIECNWGETEDVTHH------ATIPLRSGSEKFGLLNVAAPHK-THFSEEELALLEAIAFQIGTTIQRIQLVEK 168
Cdd:smart00065 68 plnIPDVEADPLFAEDLLGRYqgvrsfLAVPLVADGELVGVLALHNKKSpRPFTEEDEELLQALANQLAIALANAQLYEE 147
|
..
gi 2080646197 169 ER 170
Cdd:smart00065 148 LR 149
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
146-365 |
2.14e-51 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 171.73 E-value: 2.14e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 146 LALLEAIAFQIGTTIQRIQLVEKERKYVVVAERNRLARDLHDSVKQLLFSIMLTAKGTLNMTQDR--GLQEMLSYIGELS 223
Cdd:COG4585 22 LALVLLRARRAERAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDADpeAAREELEEIRELA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 224 QEALQEMTLLIWQLRPEGLEK-GLAEAIQNY----GKLLGVQVEVRIDGM-VSIGDEIEEVLWRISQEALHNCKKHASCE 297
Cdd:COG4585 102 REALAELRRLVRGLRPPALDDlGLAAALEELaerlLRAAGIRVELDVDGDpDRLPPEVELALYRIVQEALTNALKHAGAT 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080646197 298 KVHVLLKIENNQLHFYIEDNGIGFIQEQVRGSALGLKSMKERIQLMKGSFQITTELKKGTKIEIQLPI 365
Cdd:COG4585 182 RVTVTLEVDDGELTLTVRDDGVGFDPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
130-364 |
2.32e-23 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 100.85 E-value: 2.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 130 LLNVAAPHKthFSEEELALLEAIAFQI------GTTIQRIQLVEKE------------RKYVVVAERNR--LARDLHDSV 189
Cdd:COG3851 227 ALIAARQIS--SFHPLADLLLFLAAQSltglllGAAIQRQRQLNQQleqelrenralaRQLVSAEESERreIARELHDEI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 190 KQLLFSIMLTAKGTLNMTQDRGLQEMLSYIGELSQEALQEMTLLIWQLRPEGLEK-GLAEAIQNYGKLL-----GVQVEV 263
Cdd:COG3851 305 GQNITAIRTQASILKRLAPQPEIEQSAQSIESLALRIYDTTRRLLDRLRPAVLDElGLEEALRELPRELafeepGISCQL 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 264 RIDGMVS-IGDEIEEVLWRISQEALHNCKKHASCEKVHVLLKIENNQLHFYIEDNGIGFIQEQVRGsALGLKSMKERIQL 342
Cdd:COG3851 385 DLRGDPSlLDDTLQLTLYRLVQEALTNILKHAEASQIRISLSQDKRLLSLEIRDDGIGLPPELRAK-GFGLRGMRERVRA 463
|
250 260
....*....|....*....|..
gi 2080646197 343 MKGSFQITTElKKGTKIEIQLP 364
Cdd:COG3851 464 LGGDFRLSSA-PKGTRLSVLLP 484
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
279-364 |
4.83e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 88.76 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 279 LWRISQEALHNCKKHASCEKVHVLLKIENNQLHFYIEDNGIGFIQEQV-RGSALGLKSMKERIQLMKGSFQITTELKKGT 357
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPpGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80
|
....*..
gi 2080646197 358 KIEIQLP 364
Cdd:cd16917 81 RVTARLP 87
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
130-364 |
4.55e-17 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 82.33 E-value: 4.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 130 LLNVAAPHKTHFSEEELA-LLEAIAFQ------IGTTIQR---------IQLVEKER--KYVVVAE---RNRLARDLHDS 188
Cdd:PRK11644 233 LLNAIALIASQTWHDHPVdLLLSLLAQsltgllLGAGIQRqrelnqslqKELARNRHlaERLLETEesvRRDVARELHDE 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 189 VKQLLFSIMlTAKGTLNM--TQDRGLQEMLSYIGELSQEALQEMTLLIWQLRPEGLEK-GLAEAIQNYGKLLGVQ---VE 262
Cdd:PRK11644 313 IGQTITAIR-TQAGIIKRlaADNASVKQSAQLIEQLSLGVYDTVRRLLGRLRPRQLDDlTLEQAIRSLMREMELEdrgIV 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 263 VRIDGMV--SIGDEIEEV-LWRISQEALHNCKKHASCEKVHVLLKIENNQLHFYIEDNGIGF-IQEQVRGsaLGLKSMKE 338
Cdd:PRK11644 392 SHLDWRIdeSALSETQRVtLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLpPGSGQQG--FGLRGMRE 469
|
250 260
....*....|....*....|....*.
gi 2080646197 339 RIQLMKGSFQITTElkKGTKIEIQLP 364
Cdd:PRK11644 470 RVTALGGTLTISCT--HGTRLSVSLP 493
|
|
| GAF |
COG2203 |
GAF domain [Signal transduction mechanisms]; |
1-287 |
8.99e-15 |
|
GAF domain [Signal transduction mechanisms];
Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 75.62 E-value: 8.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 1 MHRLEALKEIAELLNEATNLQDMLEKVLHTLLQVMNLQTGWIFFIDESGKHRMLVdenLPPALTWQEKKPMCEGDCWCVE 80
Cdd:COG2203 189 LERLALLNEISQALRSALDLEELLQRILELAGELLGADRGAILLVDEDGGELELV---AAPGLPEEELGRLPLGEGLAGR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 81 RFVNGRLEKATNIIECKRIEDAIECNWGEtEDVTHHATIPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTI 160
Cdd:COG2203 266 ALRTGEPVVVNDASTDPRFAPSLRELLLA-LGIRSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQAAIAI 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 161 QRIQLVEKERKyvvvAERNRLARDLHDSVKQLLFSIMLTAKGTLNMTQDRGLQEMLSYIGELSQEALQEMTLLIWQLRPE 240
Cdd:COG2203 345 ERARLYEALEA----ALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALEG 420
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2080646197 241 GLEKGLAEAIQNYGKLLGVQVEVRIDGMVSIGDEIEEVLWRISQEAL 287
Cdd:COG2203 421 LLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEI 467
|
|
| HisKA_3 |
pfam07730 |
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ... |
177-242 |
2.42e-14 |
|
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.
Pssm-ID: 429624 [Multi-domain] Cd Length: 68 Bit Score: 67.26 E-value: 2.42e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080646197 177 ERNRLARDLHDSVKQLLFSIMLTAKGTLNMTQDR--GLQEMLSYIGELSQEALQEMTLLIWQLRPEGL 242
Cdd:pfam07730 1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDpeEAREQLDAIRELAREALQELRRLLGDLRPPAL 68
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
128-362 |
3.53e-14 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 73.55 E-value: 3.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 128 FGLLNVAAPHKTHFSEEELALLEAIAFQIGTTIQRIQLVEKERKYVVVAERNRLARDLHDSVKQLLfSIMLTAKGTLNMT 207
Cdd:PRK10600 312 YGILLATLPQGRHLSHDQQQLVDTLVEQLTATLALERQQERQQQLIVMEERATIARELHDSIAQSL-SCMKMQVSCLQMQ 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 208 QDRGLQEMLSYIGELSQE------ALQEM-TLLIWQLRPEGLEKGLAEAIQNYGKLLGVQVEVRID---GMVSIGDEIEe 277
Cdd:PRK10600 391 GDALPESSRELLSQIRNElnaswrQLRELlTTFRLQLTEPGLRPALEASCEEFSARFGFPVKLDYQlppRLVPSHQAIH- 469
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 278 vLWRISQEALHNCKKHASCEKVHVLLKIENNQLHFYIEDNGIGFIQEQVRGSALGLKSMKERIQLMKGSFQITTELKKGT 357
Cdd:PRK10600 470 -LLQIAREALSNALKHAQASEVVVTVAQNQNQVKLSVQDNGCGVPENAERSNHYGLIIMRDRAQSLRGDCRVRRRESGGT 548
|
....*
gi 2080646197 358 KIEIQ 362
Cdd:PRK10600 549 EVVVT 553
|
|
| GAF_2 |
pfam13185 |
GAF domain; The GAF domain is named after some of the proteins it is found in, including ... |
17-161 |
7.88e-13 |
|
GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433019 [Multi-domain] Cd Length: 137 Bit Score: 65.18 E-value: 7.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 17 ATNLQDMLEKVLHTLLQVMNLQTGWIFFIDESGkhRMLVDENLPPALTWQEKKPMCEGDCWcvERFVNGRLEKATNIIEC 96
Cdd:pfam13185 1 AADLEELLDAVLEAAVELGASAVGFILLVDDDG--RLAAWGGAADELSAALDDPPGEGLVG--EALRTGRPVIVNDLAAD 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080646197 97 KRIEDAIEcnwgETEDVTHHATIPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTIQ 161
Cdd:pfam13185 77 PAKKGLPA----GHAGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAIE 137
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
272-365 |
8.96e-13 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 64.21 E-value: 8.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 272 GDEIEevLWRISQEALHNCKKHA-SCEKVHVLLKIENNQLHFYIEDNGIGFIQEQV-----------------RGSALGL 333
Cdd:smart00387 1 GDPDR--LRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVEITVEDNGPGIPPEDLekifepffrtdkrsrkiGGTGLGL 78
|
90 100 110
....*....|....*....|....*....|..
gi 2080646197 334 KSMKERIQLMKGSFQITTELKKGTKIEIQLPI 365
Cdd:smart00387 79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| PtsP |
COG3605 |
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; |
3-170 |
2.88e-11 |
|
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
Pssm-ID: 442824 [Multi-domain] Cd Length: 188 Bit Score: 61.84 E-value: 2.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 3 RLEALKEIAELLNEATNLQDMLEKVLHTLLQVMNLQTGWIFFIDESGKH-RMLVDENLPPALTWQEKKPMCEGDC-WCVE 80
Cdd:COG3605 2 MLKALRRISEAVASALDLDEALDRIVRRIAEALGVDVCSIYLLDPDGGRlELRATEGLNPEAVGKVRLPLGEGLVgLVAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 81 RfvngrlEKATNIieckriedaiecnwgetEDVTHH-----------------ATIPLRSGSEKFGLLNVAAPHKTHFSE 143
Cdd:COG3605 82 R------GEPLNL-----------------ADAASHprfkyfpetgeegfrsfLGVPIIRRGRVLGVLVVQSREPREFTE 138
|
170 180
....*....|....*....|....*..
gi 2080646197 144 EELALLEAIAFQIGTTIQRIQLVEKER 170
Cdd:COG3605 139 EEVEFLVTLAAQLAEAIANAELLGELR 165
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
272-364 |
3.07e-10 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 56.99 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 272 GDEIEevLWRISQEALHNCKKHAS-CEKVHVLLKiENNQLHFYIEDNGIGFIQEQV---------------RGSALGLKS 335
Cdd:pfam02518 1 GDELR--LRQVLSNLLDNALKHAAkAGEITVTLS-EGGELTLTVEDNGIGIPPEDLprifepfstadkrggGGTGLGLSI 77
|
90 100
....*....|....*....|....*....
gi 2080646197 336 MKERIQLMKGSFQITTELKKGTKIEIQLP 364
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| GAF |
pfam01590 |
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl ... |
19-160 |
3.17e-08 |
|
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460259 [Multi-domain] Cd Length: 133 Bit Score: 51.71 E-value: 3.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 19 NLQDMLEKVLHTLLQVMNLQTGWIFFIDESGKHRmlvdenLPPALTWQEKKPMCEGDCWCVERFVNGRLEKATNIIECKR 98
Cdd:pfam01590 1 DLEEILQTILEELRELLGADRCALYLPDADGLEY------LPPGARWLKAAGLEIPPGTGVTVLRTGRPLVVPDAAGDPR 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2080646197 99 IEDAIEcnWGETEDVTHHATIPLRSGSEKFGLLNVAAPhKTHFSEEELALLEAIAFQIGTTI 160
Cdd:pfam01590 75 FLDPLL--LLRNFGIRSLLAVPIIDDGELLGVLVLHHP-RPPFTEEELELLEVLADQVAIAL 133
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
209-365 |
1.69e-07 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 52.22 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 209 DRGLQEMLSYIGELSQEALQEMTLLIWQLRPEGLEKGLAEAIQNYGKLL---GVQVEVRIDGMVSI--GDE--IEEVLWR 281
Cdd:COG0642 151 LRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAeekGIELELDLPDDLPTvrGDPdrLRQVLLN 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 282 IsqeaLHNCKKHA-SCEKVHVLLKIENNQLHFYIEDNGIGF---IQEQV-------------RGSALGLKSMKERIQLMK 344
Cdd:COG0642 231 L----LSNAIKYTpEGGTVTVSVRREGDRVRISVEDTGPGIppeDLERIfepffrtdpsrrgGGTGLGLAIVKRIVELHG 306
|
170 180
....*....|....*....|.
gi 2080646197 345 GSFQITTELKKGTKIEIQLPI 365
Cdd:COG0642 307 GTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
209-365 |
3.87e-07 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 50.68 E-value: 3.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 209 DRGLQEMLSYIGELSQEALQEMTLLIWQLRPEGLEKGLAEAIQNYGKLL---GVQVEVRIDG--MVSIGDE--IEEVLWR 281
Cdd:COG2205 60 RESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAELLEEAVEELRPLAeekGIRLELDLPPelPLVYADPelLEQVLAN 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 282 IsqeaLHNCKKHASCE-KVHVLLKIENNQLHFYIEDNGIGFIQEQ----------------VRGSALGL---KSMkerIQ 341
Cdd:COG2205 140 L----LDNAIKYSPPGgTITISARREGDGVRISVSDNGPGIPEEEleriferfyrgdnsrgEGGTGLGLaivKRI---VE 212
|
170 180
....*....|....*....|....
gi 2080646197 342 LMKGSFQITTELKKGTKIEIQLPI 365
Cdd:COG2205 213 AHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| GAF |
smart00065 |
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ... |
19-170 |
1.19e-06 |
|
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.
Pssm-ID: 214500 [Multi-domain] Cd Length: 149 Bit Score: 47.76 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 19 NLQDMLEKVLHTLLQVMNLQTGWIFFIDESgkhrmlvDENLPPALTWQEKKPMCEGDCWCVERFVNGRlekatnIIECKR 98
Cdd:smart00065 1 DLEELLQTILEELRQLLGADRVLIYLVDEN-------DRGELVLVAADGLTLPTLGIRFPLDEGLAGR------VAETGR 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 99 ---IEDAIECNWGETEDVTHH------ATIPLRSGSEKFGLLNVAAPHK-THFSEEELALLEAIAFQIGTTIQRIQLVEK 168
Cdd:smart00065 68 plnIPDVEADPLFAEDLLGRYqgvrsfLAVPLVADGELVGVLALHNKKSpRPFTEEDEELLQALANQLAIALANAQLYEE 147
|
..
gi 2080646197 169 ER 170
Cdd:smart00065 148 LR 149
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
298-365 |
4.20e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 48.48 E-value: 4.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 298 KVHVLLKIENNQLHFYIEDNGIGFIQEQV-----------RGSALGLKSMKERIQLM---KGSFQITTELKKGTKIEIQL 363
Cdd:COG2972 361 TIRISIRKEGDRLVITVEDNGVGMPEEKLeklleelsskgEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRI 440
|
..
gi 2080646197 364 PI 365
Cdd:COG2972 441 PL 442
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
118-364 |
7.51e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 47.54 E-value: 7.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 118 TIPLRSGSEKFGLLNVAAPHKThfseEELALLEAIAFQIGTTI-------QRIQLVEKErkyvvvaERNRLARDLHDSVK 190
Cdd:PRK10935 308 ILPLTMEDTVLGYLHWQASLPC----PDEPLMNNVAQMLGRGLyfnqaqkQQQQLLLME-------ERATIARELHDSLA 376
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 191 QLL--FSIMLTA-KGTLN---------MTQ-DRG-------LQEMLSY----IGELS-QEALQEMtllIWQLRPEG---- 241
Cdd:PRK10935 377 QVLsyLKIQLTLlKRSLDednakaqsiIAEfDQAlsdayrqLRELLTTfrltIQEANlGSALEEM---LDQLRNQTdaki 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 242 -LEKGLAEaiqnygKLLGVQVEVRIdgmvsigdeieevlWRISQEALHNCKKHASCEKVHVL-LKIENNQLHFYIEDNGI 319
Cdd:PRK10935 454 tLDCRLPS------QALDAQQQVHL--------------LQIIREATLNAIKHANASEIAVScVTNPDGEHTVSIRDDGI 513
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2080646197 320 GFIQEQVRGSALGLKSMKERIQLMKGSFQITTELKKGTKIEIQLP 364
Cdd:PRK10935 514 GIGELKEPEGHYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFP 558
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
286-365 |
2.83e-05 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 45.61 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 286 ALHNCKKHASCEK-VHVLLKIENNQLHFYIEDNGIG---FIQEQV----------RGSALGLKSMKERIQLMKGSFQITT 351
Cdd:COG3290 293 AIEAVEKLPEEERrVELSIRDDGDELVIEVEDSGPGipeELLEKIfergfstklgEGRGLGLALVKQIVEKYGGTIEVES 372
|
90
....*....|....
gi 2080646197 352 ELKKGTKIEIQLPI 365
Cdd:COG3290 373 EEGEGTVFTVRLPK 386
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-364 |
1.01e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 40.91 E-value: 1.01e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 304 KIENNQLHFYIEDNGIGF---IQEQVR-----GSALGLKSMKERIQLMKGS-FQITTELKKGTKIEIQLP 364
Cdd:cd16955 33 KQLKNRLHIAVEDNGIGIspkVIERVEqdempGNKIGLLNVHQRLKLGYGEgLHIRSRPDPGTLIAFYIP 102
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
19-162 |
2.26e-04 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 40.82 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 19 NLQDMLEKVLHTLLQVMNLQTGWIFFIDESGkhrmlvdENLPPALTWQEK---KPMCEGDCWCVERFVNGRLEKATNIIE 95
Cdd:pfam13492 1 SLDEILEALLKLLVRLLGAERAAVYLLDEDG-------NKLQVAAGYDGEpdpSESLDADSPLARRALSSGEPISGLGSA 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2080646197 96 CKriedaiecnwgETEDVTHHATIPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTIQR 162
Cdd:pfam13492 74 GE-----------DGLPDGPALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIEN 129
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-364 |
2.79e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 40.48 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 240 EGLEKgLAEAIQNYGKLLGVQVEVRID-GMVSIgdeieEVLWRIS---QEALHNCKKHASCEKVH--VLLKIE--NNQLH 311
Cdd:cd16951 3 EYINR-IASAINAIHAVGDIRINITGDtGPVSS-----EVATAIGlvvNELLQNALKHAFSDREGgtITIRSVvdGDYLR 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2080646197 312 FYIEDNGIGFIQEQ--VRGSALGLKSMKERIQLMKGSFQITTELKKGTKIEIQLP 364
Cdd:cd16951 77 ITVIDDGVGLPQDEdwPNKGSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| PRK13558 |
PRK13558 |
bacterio-opsin activator; Provisional |
95-229 |
5.50e-04 |
|
bacterio-opsin activator; Provisional
Pssm-ID: 237426 [Multi-domain] Cd Length: 665 Bit Score: 41.75 E-value: 5.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 95 ECKRIEDAIECNWGETEDVTHHATIPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTIQRIQlvekERKYVV 174
Cdd:PRK13558 370 ETEAVESTDVDGVSGTVDGSAVAAVPLVYRETTYGVLVVYTAEPDEIDDRERVVLEALGRAVGAAINALE----SRRTLT 445
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2080646197 175 VAERNRLARDLHDSVkqlLFSIMLTAKGTLNMTQ------DRGLQEMLSYIGELSQEALQE 229
Cdd:PRK13558 446 TDEVLELEVELSDPD---LFLVELAAATDCRLEYrgsiadDDGGVLVLFTVPGDDATALVD 503
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
298-365 |
5.54e-04 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 41.49 E-value: 5.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 298 KVHVLLKIENNQLHFYIEDNGIGF---IQEQV---------RGSALGLkSM-KERIQLMKGSFQITTELKKGTKIEIQLP 364
Cdd:COG5000 338 EIEVSTRREDGRVRIEVSDNGPGIpeeVLERIfepffttkpKGTGLGL-AIvKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
.
gi 2080646197 365 I 365
Cdd:COG5000 417 L 417
|
|
| FhlA |
COG3604 |
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ... |
119-161 |
7.45e-04 |
|
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 442823 [Multi-domain] Cd Length: 338 Bit Score: 40.99 E-value: 7.45e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2080646197 119 IPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTIQ 161
Cdd:COG3604 79 VPLRVGGEVLGVLTLDSRRPGAFSEEDLRLLETLASLAAVAIL 121
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
287-365 |
9.47e-04 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 40.69 E-value: 9.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 287 LHNCKKHASCE-KVHVLLKIENNQLHFYIEDNGIGFIQE------------------QVRGSALGLKSMKERIQLMKGSF 347
Cdd:COG5002 290 LDNAIKYTPEGgTITVSLREEDDQVRISVRDTGIGIPEEdlpriferfyrvdksrsrETGGTGLGLAIVKHIVEAHGGRI 369
|
90
....*....|....*...
gi 2080646197 348 QITTELKKGTKIEIQLPI 365
Cdd:COG5002 370 WVESEPGKGTTFTITLPL 387
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
300-364 |
9.81e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 38.24 E-value: 9.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 300 HVLLKI-------ENNQLHFYIEDNGIGFIQEQVR------------------GSALGLKSMKERIQLMKGSFQITTELK 354
Cdd:cd16922 20 EVTLRVsleeeeeDGVQLRFSVEDTGIGIPEEQQArlfepfsqadssttrkygGTGLGLAISKKLVELMGGDISVESEPG 99
|
90
....*....|
gi 2080646197 355 KGTKIEIQLP 364
Cdd:cd16922 100 QGSTFTFTLP 109
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
285-365 |
1.57e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 40.27 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 285 EALHNCKKHASCE----KVHVLLKIENNQLHFYIEDNGIGF--IQEQVRGSALGLKSMKERIQLMKGSFQITTElkKGTK 358
Cdd:COG3920 406 ELVTNALKHAFLSgeggRIRVSWRREDGRLRLTVSDNGVGLpeDVDPPARKGLGLRLIRALVRQLGGTLELDRP--EGTR 483
|
....*..
gi 2080646197 359 IEIQLPI 365
Cdd:COG3920 484 VRITFPL 490
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
271-364 |
5.54e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 38.74 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 271 IGDEIEEVLwrisqEALHNCKKHasceKVHVLLKIENNQLHFYIEDNGIGF---IQEQV-----------RGsaLGLKSM 336
Cdd:PRK11086 438 LGNLIENAL-----EAVGGEEGG----EISVSLHYRNGWLHCEVSDDGPGIapdEIDAIfdkgystkgsnRG--VGLYLV 506
|
90 100
....*....|....*....|....*...
gi 2080646197 337 KERIQLMKGSFQITTELKKGTKIEIQLP 364
Cdd:PRK11086 507 KQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-364 |
5.93e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 36.25 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 289 NCKKHASCEK-----VHVLLKIENNQLHFYIEDNGIGfIQEQVR------------GSALGLKSMKERIQLMKGS---FQ 348
Cdd:cd16957 12 NAIRHAFPKRkenneVRVVVKKDQHKVHVSVSDNGQG-IPEERLdllgkttvtsekGTGTALENLNRRLIGLFGSeacLH 90
|
90
....*....|....*.
gi 2080646197 349 ITTELKKGTKIEIQLP 364
Cdd:cd16957 91 IESEVHGGTEVWFVIP 106
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
186-365 |
8.75e-03 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 37.86 E-value: 8.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 186 HDsVKQLLFSIMLTAKGTLNMTQDRGLQEMLSYIGELSQEALQEMTLLIWQL----RPEGLEKG---LAEAIQNYGKLL- 257
Cdd:COG4191 151 HE-INNPLAAILGNAELLRRRLEDEPDPEELREALERILEGAERAAEIVRSLrafsRRDEEEREpvdLNELIDEALELLr 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080646197 258 ------GVQVEVRIDG---MVSI-GDEIEEVLWRI---SQEALHNCKKHasceKVHVLLKIENNQLHFYIEDNGIGfIQE 324
Cdd:COG4191 230 prlkarGIEVELDLPPdlpPVLGdPGQLEQVLLNLlinAIDAMEEGEGG----RITISTRREGDYVVISVRDNGPG-IPP 304
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2080646197 325 QVR---------------GSALGLkSM-KERIQLMKGSFQITTELKKGTKIEIQLPI 365
Cdd:COG4191 305 EVLerifepffttkpvgkGTGLGL-SIsYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| MsrC |
COG1956 |
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, ... |
119-162 |
9.87e-03 |
|
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms];
Pssm-ID: 441559 [Multi-domain] Cd Length: 156 Bit Score: 36.34 E-value: 9.87e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 2080646197 119 IPLRSGSEKFGLLNVAAPHKTHFSEEELALLEAIAFQIGTTIQR 162
Cdd:COG1956 113 VPIFKDGEVIGVLDIDSPTPGRFDEEDQAGLEALAALLAEALDA 156
|
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