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Conserved domains on  [gi|2080773313|ref|WP_220401411|]
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universal stress protein [Escherichia coli]

Protein Classification

universal stress protein( domain architecture ID 10456835)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0016208|GO:0005524
PubMed:  12732303
SCOP:  4003850

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 162-273 1.01e-18

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


:

Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.08  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 162 MFAFDGSEESRSNLERLTMSPLLRGLECHLAMV--------------------NGKKEELL-TAQQILRDAGIENSTTHL 220
Cdd:cd00293     3 LVAVDGSEESERALEWALELAKRPGAELTLLHVvdpppssslsggleeladelKEEAEELLeEAKKLAEEAGVEVETIVV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2080773313 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:cd00293    83 EG-DPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-152 5.43e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


:

Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.43  E-value: 5.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   5 VTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEIEgqrnrllmaqgkai 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALA-------------- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080773313  85 lescAEMLQKQGSPDVLLMQKHGTPDEIL---AELSDLRLMVLGRRG----SQHPVGSHLESVIRLQKKPLLVVP 152
Cdd:pfam00582  67 ----AAAAAEAGGVKVEVVVVVGDPAEEIlevAEEEDADLIVMGSRGrsglSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 162-273 1.01e-18

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.08  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 162 MFAFDGSEESRSNLERLTMSPLLRGLECHLAMV--------------------NGKKEELL-TAQQILRDAGIENSTTHL 220
Cdd:cd00293     3 LVAVDGSEESERALEWALELAKRPGAELTLLHVvdpppssslsggleeladelKEEAEELLeEAKKLAEEAGVEVETIVV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2080773313 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:cd00293    83 EG-DPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
160-273 1.07e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 79.96  E-value: 1.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 160 RAMFAFDGSEESRSNLERLTMSPLLRGLECHLAMV-------------------NGKKEELLTAQQILRDAGIENSTTHL 220
Cdd:COG0589     4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVvdpppsaaagpeeleeelrEEAEEALEEAAERLEEAGVEVETVVR 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2080773313 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:COG0589    84 EG-DPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 162-275 4.47e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.43  E-value: 4.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 162 MFAFDGSEESRSNLER----------------------LTMSPLLRGLECHLAMVNGKKEELLTAQQILRDAGIENSTTH 219
Cdd:pfam00582   2 LVAVDGSEESKRALEWaaelakargaelillhvidpppSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEVV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2080773313 220 LTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLILR 275
Cdd:pfam00582  82 VVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-152 5.43e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.43  E-value: 5.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   5 VTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEIEgqrnrllmaqgkai 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALA-------------- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080773313  85 lescAEMLQKQGSPDVLLMQKHGTPDEIL---AELSDLRLMVLGRRG----SQHPVGSHLESVIRLQKKPLLVVP 152
Cdd:pfam00582  67 ----AAAAAEAGGVKVEVVVVVGDPAEEIlevAEEEDADLIVMGSRGrsglSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-151 6.04e-14

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 66.99  E-value: 6.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   4 TVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLtgtlgidsqqlltdelveiEGQRNRLLMAQGKA 83
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGG-------------------LEELADELKEEAEE 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080773313  84 ILESCAEMLQKQGsPDVLLMQKHGTP-DEILAELSDLR--LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:cd00293    62 LLEEAKKLAEEAG-VEVETIVVEGDPaEAILEEAKELGadLIVMGSRGrsglKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-151 4.25e-12

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 62.25  E-value: 4.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   1 MNNTVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVvsdltgtlgiDSQQLLTDELVEiegqrnrllmaQ 80
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAA----------AGPEELEEELRE-----------E 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080773313  81 GKAILESCAEMLQKQGsPDVLLMQKHGTPDEILAELSDLR---LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:COG0589    60 AEEALEEAAERLEEAG-VEVETVVREGDPAEAILEAAEELdadLIVMGSRGrsglRRLLLGSVAERVLRHAPCPVLVV 136
 
Name Accession Description Interval E-value
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 162-273 1.01e-18

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.08  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 162 MFAFDGSEESRSNLERLTMSPLLRGLECHLAMV--------------------NGKKEELL-TAQQILRDAGIENSTTHL 220
Cdd:cd00293     3 LVAVDGSEESERALEWALELAKRPGAELTLLHVvdpppssslsggleeladelKEEAEELLeEAKKLAEEAGVEVETIVV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2080773313 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:cd00293    83 EG-DPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
160-273 1.07e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 79.96  E-value: 1.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 160 RAMFAFDGSEESRSNLERLTMSPLLRGLECHLAMV-------------------NGKKEELLTAQQILRDAGIENSTTHL 220
Cdd:COG0589     4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVvdpppsaaagpeeleeelrEEAEEALEEAAERLEEAGVEVETVVR 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2080773313 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:COG0589    84 EG-DPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 162-275 4.47e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.43  E-value: 4.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 162 MFAFDGSEESRSNLER----------------------LTMSPLLRGLECHLAMVNGKKEELLTAQQILRDAGIENSTTH 219
Cdd:pfam00582   2 LVAVDGSEESKRALEWaaelakargaelillhvidpppSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEVV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2080773313 220 LTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLILR 275
Cdd:pfam00582  82 VVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-152 5.43e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.43  E-value: 5.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   5 VTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEIEgqrnrllmaqgkai 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALA-------------- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080773313  85 lescAEMLQKQGSPDVLLMQKHGTPDEIL---AELSDLRLMVLGRRG----SQHPVGSHLESVIRLQKKPLLVVP 152
Cdd:pfam00582  67 ----AAAAAEAGGVKVEVVVVVGDPAEEIlevAEEEDADLIVMGSRGrsglSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-151 6.04e-14

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 66.99  E-value: 6.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   4 TVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLtgtlgidsqqlltdelveiEGQRNRLLMAQGKA 83
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGG-------------------LEELADELKEEAEE 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080773313  84 ILESCAEMLQKQGsPDVLLMQKHGTP-DEILAELSDLR--LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:cd00293    62 LLEEAKKLAEEAG-VEVETIVVEGDPaEAILEEAKELGadLIVMGSRGrsglKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-151 4.25e-12

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 62.25  E-value: 4.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   1 MNNTVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVvsdltgtlgiDSQQLLTDELVEiegqrnrllmaQ 80
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAA----------AGPEELEEELRE-----------E 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080773313  81 GKAILESCAEMLQKQGsPDVLLMQKHGTPDEILAELSDLR---LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:COG0589    60 AEEALEEAAERLEEAG-VEVETVVREGDPAEAILEAAEELdadLIVMGSRGrsglRRLLLGSVAERVLRHAPCPVLVV 136
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 224-275 3.44e-06

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 45.69  E-value: 3.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2080773313 224 SVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLILR 275
Cdd:cd23659    92 DPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 193-275 4.98e-05

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 42.26  E-value: 4.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313 193 MVNGKKEELLTAQQILRDA-GIENSTTHLTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPL 271
Cdd:cd23660    64 YVDAIRGRHLEAMKALRQKfGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDL 143


                  ....
gi 2080773313 272 LILR 275
Cdd:cd23660   144 LALK 147
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 8-128 2.47e-03

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 37.60  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080773313   8 CVDGSlstrSVCEYA-AWAARTL---QSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEiegqrnrllmaqgkA 83
Cdd:cd23659     6 AVDGS----EESEYAlEWALENLhrpGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKAE--------------K 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2080773313  84 ILESCAEMLQKQGSPDVLLMQKHGTPDEILAELSD---LRLMVLGRRG 128
Cdd:cd23659    68 LLEKYEKKLKEEKGIKVKVEVVAGDPGEVICKAAEelkADLIVMGSRG 115
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 211-275 5.89e-03

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 36.13  E-value: 5.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2080773313 211 AGIENSTTHLTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQffIGSHTSEMLQKTQQPLLILR 275
Cdd:cd23657    75 AGYPVDHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLSL--LGSSARAVLNSAPCDVLIVP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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