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Conserved domains on  [gi|2087760997|ref|WP_222246771|]
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helix-turn-helix transcriptional regulator [Rhizobium leguminosarum]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-95 7.84e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.18  E-value: 7.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2087760997   1 METSDLADHttvAAALLSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYSSS 80
Cdd:COG0640     1 MSETKELEE---LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                          90
                  ....*....|....*
gi 2087760997  81 SEPVMKILATLEDIY 95
Cdd:COG0640    78 DEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-95 7.84e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.18  E-value: 7.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2087760997   1 METSDLADHttvAAALLSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYSSS 80
Cdd:COG0640     1 MSETKELEE---LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                          90
                  ....*....|....*
gi 2087760997  81 SEPVMKILATLEDIY 95
Cdd:COG0640    78 DEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-88 2.26e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.52  E-value: 2.26e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2087760997  13 AAALLSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYSSSSEPVMKIL 88
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-93 8.90e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.48  E-value: 8.90e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2087760997  17 LSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYS-SSSEPVMKILATLED 93
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSlTDAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-91 2.58e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.85  E-value: 2.58e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2087760997   28 ILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYSSSSEPVMKILATL 91
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 22-66 1.09e-09

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 49.36  E-value: 1.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2087760997  22 NPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLV 66
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 19-78 5.92e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 48.56  E-value: 5.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2087760997  19 AMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYS 78
Cdd:NF033789    4 ALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYS 63
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 2-67 2.99e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.02  E-value: 2.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2087760997   2 ETSDLADHTTVAAALLSAMANPKRLLILCSLV-KGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVK 67
Cdd:TIGR01884 122 ESEELISFIDLDLVPLLAGLSREELKILEVLKaTGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-95 7.84e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.18  E-value: 7.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2087760997   1 METSDLADHttvAAALLSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYSSS 80
Cdd:COG0640     1 MSETKELEE---LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                          90
                  ....*....|....*
gi 2087760997  81 SEPVMKILATLEDIY 95
Cdd:COG0640    78 DEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-88 2.26e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.52  E-value: 2.26e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2087760997  13 AAALLSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYSSSSEPVMKIL 88
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-93 8.90e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.48  E-value: 8.90e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2087760997  17 LSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYS-SSSEPVMKILATLED 93
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSlTDAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-91 2.58e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.85  E-value: 2.58e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2087760997   28 ILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYSSSSEPVMKILATL 91
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 22-66 1.09e-09

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 49.36  E-value: 1.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2087760997  22 NPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLV 66
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 19-78 5.92e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 48.56  E-value: 5.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2087760997  19 AMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKTRRDAQTIYYS 78
Cdd:NF033789    4 ALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYS 63
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
1-85 2.26e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 44.95  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2087760997   1 METSDLADhttvAAALLSAMANPKRLLILCSLVKGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVKT-----RRDAQTI 75
Cdd:COG4189     1 MVVLDDEE----SLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTeykpgKRGRQKI 76

                          90
                  ....*....|
gi 2087760997  76 YYSSSSEPVM 85
Cdd:COG4189    77 CYLRVDKILI 86
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 2-67 2.99e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.02  E-value: 2.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2087760997   2 ETSDLADHTTVAAALLSAMANPKRLLILCSLV-KGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVK 67
Cdd:TIGR01884 122 ESEELISFIDLDLVPLLAGLSREELKILEVLKaTGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 17-67 4.22e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 34.66  E-value: 4.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2087760997  17 LSAMANPKRLLILCSLV-KGEVAVGVLATQVGLSQSALSQHLSKLRAQKLVK 67
Cdd:cd09655   133 LLAGLSREELKILEVLKaKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVE 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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