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Conserved domains on  [gi|2089868553|ref|WP_222737115|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Vibrio]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-135 9.43e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 102.36  E-value: 9.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089868553   2 SRQKFGIQFSIAARLWRRHLDQRLAHAGIKDISWAPLLHLDEFGdGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQA 81
Cdd:COG1846     8 AEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG-GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2089868553  82 DSHDRRAKRIYLTDAGREQVGALRAELLQIETEMLADVSDEQIDVMLEVLDGLI 135
Cdd:COG1846    87 DPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-135 9.43e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 102.36  E-value: 9.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089868553   2 SRQKFGIQFSIAARLWRRHLDQRLAHAGIKDISWAPLLHLDEFGdGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQA 81
Cdd:COG1846     8 AEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG-GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2089868553  82 DSHDRRAKRIYLTDAGREQVGALRAELLQIETEMLADVSDEQIDVMLEVLDGLI 135
Cdd:COG1846    87 DPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 15-140 3.25e-25

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 93.15  E-value: 3.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089868553  15 RLWRRHLDQRLAHAGIKDISWAPLLHLDEFGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRAKRIYLT 94
Cdd:PRK03573   14 RIWRALIDHRLKPLELTQTHWVTLHNIHQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLT 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2089868553  95 DAGREQVGALRAELLQIETEMLADVSDEQIDvmleVLDGLITKFKH 140
Cdd:PRK03573   94 EKAEPLISEVEAVINKTRAEILHGISAEEIE----QLITLIAKLEK 135
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
46-124 8.66e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 70.32  E-value: 8.66e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2089868553   46 DGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRAKRIYLTDAGREQVGALRAELLQIETEMLADVSDEQI 124
Cdd:smart00347  23 GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-88 1.50e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 45.27  E-value: 1.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089868553  29 GIKDISWAPLLHLDEfGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRA 88
Cdd:pfam12802   2 GLTPAQFRVLLALAR-NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-135 9.43e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 102.36  E-value: 9.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089868553   2 SRQKFGIQFSIAARLWRRHLDQRLAHAGIKDISWAPLLHLDEFGdGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQA 81
Cdd:COG1846     8 AEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG-GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2089868553  82 DSHDRRAKRIYLTDAGREQVGALRAELLQIETEMLADVSDEQIDVMLEVLDGLI 135
Cdd:COG1846    87 DPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 15-140 3.25e-25

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 93.15  E-value: 3.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089868553  15 RLWRRHLDQRLAHAGIKDISWAPLLHLDEFGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRAKRIYLT 94
Cdd:PRK03573   14 RIWRALIDHRLKPLELTQTHWVTLHNIHQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLT 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2089868553  95 DAGREQVGALRAELLQIETEMLADVSDEQIDvmleVLDGLITKFKH 140
Cdd:PRK03573   94 EKAEPLISEVEAVINKTRAEILHGISAEEIE----QLITLIAKLEK 135
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
46-124 8.66e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 70.32  E-value: 8.66e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2089868553   46 DGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRAKRIYLTDAGREQVGALRAELLQIETEMLADVSDEQI 124
Cdd:smart00347  23 GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-88 1.50e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 45.27  E-value: 1.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089868553  29 GIKDISWAPLLHLDEfGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRA 88
Cdd:pfam12802   2 GLTPAQFRVLLALAR-NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 46-89 1.55e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.92  E-value: 1.55e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2089868553  46 DGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRAK 89
Cdd:pfam01047  16 GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_27 pfam13463
Winged helix DNA-binding domain;
35-97 9.36e-06

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 41.12  E-value: 9.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2089868553  35 WAPLLHLDEFGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRAKRIYLTDAG 97
Cdd:pfam13463   6 ALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
62-117 1.42e-05

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 41.08  E-value: 1.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2089868553  62 STLVRLLDTLEQKGQIE-RQADSHDRRAKRIY-LTDAGREQVGALRAELLQIETEMLA 117
Cdd:COG1695    45 GTLYPALKRLEKEGLVEsEWEESEGGPRRKYYrLTEAGREELAEWLEEWEKLAEALEA 102
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 48-99 1.40e-04

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 39.73  E-value: 1.40e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2089868553  48 ISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADSHDRRAKRIYLTDAGRE 99
Cdd:PRK10870   72 IQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHE 123
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
38-99 3.83e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.18  E-value: 3.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2089868553  38 LLHLDEFGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQADshdrraKRIYLTDAGRE 99
Cdd:COG1321    15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPY------GGITLTEEGRE 70
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
38-87 4.71e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 35.57  E-value: 4.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2089868553  38 LLHLDEFGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERqaDSHDRR 87
Cdd:COG1414    15 LEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVER--DPEGGR 62
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 38-99 7.77e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.35  E-value: 7.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2089868553  38 LLHLDEFGDGISQKDLAASVGMEGSTLVRLLDTLEQKGQIERQadsHDRRAKRIYLTDAGRE 99
Cdd:COG2512    21 LELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE---RVGRENVVELPEDEPE 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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