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Conserved domains on  [gi|2096273302|ref|WP_223223800|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Staphylococcus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
2-58 6.03e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 48.45  E-value: 6.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2096273302   2 RKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQLIYGD 58
Cdd:COG1396    16 RKARGLTQEELAERL--GVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGA 70
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
2-58 6.03e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 48.45  E-value: 6.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2096273302   2 RKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQLIYGD 58
Cdd:COG1396    16 RKARGLTQEELAERL--GVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGA 70
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
1-54 1.27e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 1.27e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2096273302    1 MRKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQL 54
Cdd:smart00530   5 LREEKGLTQEELAEKL--GVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 1-54 2.11e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 43.31  E-value: 2.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2096273302   1 MRKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQL 54
Cdd:cd00093     7 LRKEKGLTQEELAEKL--GVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 1-54 3.96e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 42.53  E-value: 3.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2096273302   1 MRKELGLTMEEFGEKFTHkaHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQL 54
Cdd:pfam01381   4 LREELGLSQEELAEKLGV--SRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 2-58 3.59e-03

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 36.37  E-value: 3.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2096273302   2 RKELGLTMEEFGeKFTHKAHKSiVSKWEKGLTKPSNERLKEIAKLGNISVHQLIYGD 58
Cdd:PRK09706   14 RKQLKLSQRSLA-KAVKVSHVS-ISQWERDETEPTGKNLFALAKALQCSPTWLLFGD 68
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
2-58 6.03e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 48.45  E-value: 6.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2096273302   2 RKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQLIYGD 58
Cdd:COG1396    16 RKARGLTQEELAERL--GVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGA 70
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
1-54 1.27e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 1.27e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2096273302    1 MRKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQL 54
Cdd:smart00530   5 LREEKGLTQEELAEKL--GVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 1-54 2.11e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 43.31  E-value: 2.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2096273302   1 MRKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQL 54
Cdd:cd00093     7 LRKEKGLTQEELAEKL--GVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 1-54 3.96e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 42.53  E-value: 3.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2096273302   1 MRKELGLTMEEFGEKFTHkaHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQL 54
Cdd:pfam01381   4 LREELGLSQEELAEKLGV--SRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-58 2.45e-05

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 40.99  E-value: 2.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2096273302   1 MRKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNISVHQLIYGD 58
Cdd:COG1476    12 LRKERGLTQEELAELL--GVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLE 67
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 2-50 3.10e-05

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 40.69  E-value: 3.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2096273302   2 RKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPSNERLKEIAKLGNIS 50
Cdd:COG1813    21 REARGLSQEELAEKL--GVSESTIRRIERGEATPSLDTLRKLEKALGIS 67
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
1-36 9.32e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 36.45  E-value: 9.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2096273302   1 MRKELGLTMEEFGEKFthKAHKSIVSKWEKGLTKPS 36
Cdd:COG2944    14 LRERLGLSQAEFAALL--GVSVSTVRRWEQGRRKPS 47
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 2-58 3.59e-03

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 36.37  E-value: 3.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2096273302   2 RKELGLTMEEFGeKFTHKAHKSiVSKWEKGLTKPSNERLKEIAKLGNISVHQLIYGD 58
Cdd:PRK09706   14 RKQLKLSQRSLA-KAVKVSHVS-ISQWERDETEPTGKNLFALAKALQCSPTWLLFGD 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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