|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
11-1041 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 798.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 11 IISWFARNSVAANLLMIAIIVAGIIGISKLRQQVFPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNS 90
Cdd:COG0841 3 LSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 91 SAREGSGSINIEVEEGYNVASVLDEVKIRIDSI-PNLPDLAERPVIYE-NRMQRQVMWISVFGD-AGERVLKEYA-NDIK 166
Cdd:COG0841 83 TSSEGSSSITVEFELGTDIDEALVDVQNAVDRArSDLPEDVEPPGVTKvNPSDFPVMVLALSSDdLDELELSDYAeRNIK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 167 TELLGQPNVSIVQVNGTRPYEVGIMVSDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIKTRGGDILVRTKNQAYTGLDFAQ 246
Cdd:COG0841 163 DRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFEN 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 247 IPLmTLPDGTTLLVGDIAAIDDGFAEYQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGD 326
Cdd:COG0841 243 IVI-RTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVYD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 327 GTYYLKGRLEMMQKNMIAGVILVFIVLALFLR-FKLAFWVMIGIPLCFLGAFALMYmypAFAMTINMITLFGFILVLGIV 405
Cdd:COG0841 322 QSEFIRASIEEVVKTLLEAILLVVLVVFLFLRsWRATLIPAVAIPVSLIGTFAVMY---LLGFSLNILTLFALVLAIGIV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 406 VDDAIIIAESAWSSIEKHGHSVDSVIKGARKVALPATFGVLTTMAAFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESK 485
Cdd:COG0841 399 VDDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVAL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 486 LILPAHLAHMKLNKVEDTKNPLLRKVKQFFRGIRlaisgalkrfisNVYAPGLKKLLNYRGLTVLSFICLLLITTVGFis 565
Cdd:COG0841 479 TLTPALCARLLKPHPKGKKGRFFRAFNRGFDRLT------------RGYGRLLRWALRHRKLTLLVALALLALSVLLF-- 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 566 gGLVKTTMMPNVPGDGVFVEVKMAEGSTAEQTIRSITIVEEKLNEIhEEVKAKYG-TGVkqhSVTWTNNNTGAyMWTELV 644
Cdd:COG0841 545 -GRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEV-PEVESVFSvVGF---SGGGSGSNSGT-IFVTLK 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 645 KSENMPINQYEFTDMWRDRVGQLPSVQEVSFGNGGPGGGGVG---YRLIGSDIDELQTVSEKIKTKLSEYDGVYDISDGL 721
Cdd:COG0841 619 PWDERDRSADEIIARLREKLAKIPGARVFVFQPPAGGLGSGApieVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDL 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 722 SGGKEEIVVDLK-PHGRNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPIRTPDGDYVT 800
Cdd:COG0841 699 QLGKPELQLDIDrEKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVP 778
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 801 FSDVATYKVSEGYSRISRIDGVRANRISADVSQQaaITPGEVhMDMMQNVIPDIlQEHPSVKLVPGGPSEDEQVLQDEMA 880
Cdd:COG0841 779 LSSVATIEEGTGPSSINRYNGQRSVTVSANLAPG--VSLGEA-LAAIEELAAEL-KLPPGVSIEFTGQAEEEQESFSSLG 854
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 881 LGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVDFIGRARE 960
Cdd:COG0841 855 LAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLRE 934
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 961 EGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFATLITLVWVPCLYVLMGNTRDW 1040
Cdd:COG0841 935 EGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRR 1014
|
.
gi 2100537107 1041 F 1041
Cdd:COG0841 1015 L 1015
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
44-1033 |
1.02e-131 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 424.78 E-value: 1.02e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 44 VFPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSAREGSGSINIEVEEGYNVASVLDEVKIRIDSI 123
Cdd:pfam00873 34 AFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQSSYGLSSITLTFELGTDIDIARQDVQNRLQLA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 124 -PNLPDLAERPVIY-ENRMQRQVMWISVFGDAGERV---LKEYA-NDIKTELLGQPNVSIVQVNGTRPYEVGIMVSDYQL 197
Cdd:pfam00873 114 tPLLPEGVQRPGISvIKTSLGPIMVLAVTSPDGSYTqtdLRDYAdTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 198 RKYGLTLQQVAQAIRSYSLDLPSGTIKTRGGDILVRTKNQAYTGLDFAQIPLMTlPDGTTLLVGDIAAIDDGFAEYQFIS 277
Cdd:pfam00873 194 ARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDFEKIIVKN-QDGSPVRLRDVATVELGSELYRGFA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 278 RFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDGTYYLKGRLEMMQKNMIAGVILVFIVLALFL 357
Cdd:pfam00873 273 TFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFL 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 358 R-FKLAFWVMIGIPLCFLGAFALMYmypAFAMTINMITLFGFILVLGIVVDDAIIIAESAWSSIEKHG-HSVDSVIKGAR 435
Cdd:pfam00873 353 QnWRATLIPAIAIPLSLLGTFAVMK---AFGFSINTLTLGGLVLAIGLVVDDAIVVVENIERVLEENGlKPLEAAYKSMG 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 436 KVALPATFGVLTTMAAFYPTLAISGpWTNAM-ASMGLVVIFCLMFSLVESKLILPAHLAHMklnkvedTKNPLLRKVKQF 514
Cdd:pfam00873 430 EIGGALVAIALVLSAVFLPILFLGG-LTGRIfRQFAITIVLAILLSVLVALTLTPALCATL-------LKPRREPKHGGF 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 515 FRGirlaiSGALKRFISNVYAPGLKKLLNYRGLTVLSFICLLLITTVGFISgglVKTTMMPNVpGDGVFV-EVKMAEGST 593
Cdd:pfam00873 502 FRW-----FNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVR---IPTEFLPEE-DEGVFVtSAQLPPGVS 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 594 AEQTIRSITIVEEKLNEiHEEVKAKYG-TGVKQHSVTWTNNNTGAYM----WTELVKSENmpiNQYEFTDMWRDRVGQLP 668
Cdd:pfam00873 573 LDQTQRVMKQVEKILKE-KPEVESVFAvTGFAFSGDNNGPNSGDAFIslkpWKERPGPEK---SVQALIERLRKALKQIP 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 669 SV-------QEVSFGNGGPGG-GGVGYRLIGSDIDELQTVSEKIKTKLSEYDGVYDI-SDGLSGGKEEIVVDLKPHGRNL 739
Cdd:pfam00873 649 GAnvflfqpIQLRGLGTISGFrSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVrSDGQEDQPQLQVNIDREKAARL 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 740 GLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPIRTPDGDYVTFSDVATYKVSEGYSRISRI 819
Cdd:pfam00873 729 GVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWGYGPPSINRY 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 820 DGVRANRISADVSqqaaitPGEVHMDMMQnVIPDILQEhpsVKLVPG------GPSEDEQVLQDEMALGGLIALLMIYGL 893
Cdd:pfam00873 809 NGFRSIVISGNVA------AGDSLGDAME-AMAQIAKQ---VKLPPGygytwtGQFEQEQLAGNSLPILIALALLVVFLV 878
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 894 MAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVDFIGRARE-EGMSRIDAAVNA 972
Cdd:pfam00873 879 LAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREqEGKSLEEAILEA 958
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2100537107 973 GTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFATLITLVWVPCLYVL 1033
Cdd:pfam00873 959 CRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVL 1019
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
165-1035 |
1.90e-93 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 320.82 E-value: 1.90e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 165 IKTELLGQPNVSIVQVNG--TRPYEVgiMVSDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIKTRGGDILVRTKNQAYTGL 242
Cdd:COG3696 164 IRPQLRSVPGVAEVNSFGgfVKQYQV--LVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSLE 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 243 DFAQIPLMTlPDGTTLLVGDIAAIDDGFAEYQFISRFDGKD-----AVNMRIQA-SLEsddllIAEEVYAYLDKKQSELP 316
Cdd:COG3696 242 DIENIVVKT-RNGTPVLLRDVAEVRIGPAPRRGAATLNGEGevvggIVLMLKGEnALE-----VIEAVKAKLAELKPSLP 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 317 HGISIDawgdgTYY----LKGR-LEMMQKNMIAGVILVFIVLALFLR-FKLAFWVMIGIPLCFLGAFALMYmypAFAMTI 390
Cdd:COG3696 316 EGVKIV-----PFYdrsdLIDRaIHTVTKNLLEGALLVILVLFLFLGnLRAALIVALAIPLSLLFAFIVMR---LFGISA 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 391 NMITLFGFILVLGIVVDDAIIIAESAWSSIEKHGHSV------DSVIKGARKVALPATFGVLTTMAAFYPTLAISG---- 460
Cdd:COG3696 388 NLMSLGGLAIDFGIIVDGAVVMVENILRRLEENRAAGtprerlEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGvegk 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 461 ---PwtnamasMGLVVIFCLMFSLVESKLILPAhLAHMKL-NKVEDTKNPLLRKVKqffrgirlaisgalkrfisNVYAP 536
Cdd:COG3696 468 lfrP-------MALTVIFALLGALLLSLTLVPV-LASLLLrGKVPEKENPLVRWLK-------------------RLYRP 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 537 GLKKLLNYRGLTVLSFICLLLITTVGFisgGLVKTTMMPNVP-GDgVFVEVKMAEGSTAEQTIRSITIVEEKLNEIhEEV 615
Cdd:COG3696 521 LLRWALRHPKLVLAVALVLLVLALALF---PRLGSEFLPELDeGD-LLVMATLPPGISLEESVELGQQVERILKSF-PEV 595
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 616 K---AKYGT-----------------GVKQHSvTWTNNNTGAYMWTELVKS-ENMPINQYEFTDMWRDRVGQLPS--VQE 672
Cdd:COG3696 596 EsvvSRTGRaedatdpmgvnmsetfvILKPRS-EWRSGRTKEELIAEMREAlEQIPGVNFNFSQPIQMRVDELLSgvRAD 674
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 673 VSFgnggpggggvgyRLIGSDIDELQTVSEKIKTKLSEYDGVYDISDGLSGGKEEIVVDLKPH--GRnLGLTVQGLSTQV 750
Cdd:COG3696 675 VAV------------KIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDaaAR-YGLNVADVQDVV 741
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 751 RNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPIRTPDGDYVTFSDVATYKVSEGYSRISRIDGVRANRISAD 830
Cdd:COG3696 742 ETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQAN 821
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 831 VSQ----------QAAITpGEVHMDmmqnvipdilqehPSVKLVPGGPSEDEQVLQDEMALGGLIALLMIYGLMAIPLKS 900
Cdd:COG3696 822 VRGrdlgsfvaeaQAKVA-EQVKLP-------------PGYYIEWGGQFENLQRATARLAIVVPLALLLIFLLLYLAFGS 887
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 901 YVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVDFIGRAREEGMSRIDAAVNAGTQRFRAI 980
Cdd:COG3696 888 VRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIEGALERLRPV 967
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 2100537107 981 ILTSLTTFFGLLPITMETSLQAQLVIPMA-VSLGfGIVFATLITLVWVPCLYVLMG 1035
Cdd:COG3696 968 LMTALVAALGLLPMALSTGPGSEVQRPLAtVVIG-GLITSTLLTLLVLPALYLLFG 1022
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
13-1033 |
2.27e-93 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 320.42 E-value: 2.27e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 13 SWFARNSVAANLLMIAIIVAGIIGISKLRQQVFPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSA 92
Cdd:NF033617 2 DVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 93 REGSGSINIEVEEGYNVASVLDEVKIRIDSIPN-LPDLAERPVIYENR--MQRQVMWISVFGDAGERV-LKEYANDIKTE 168
Cdd:NF033617 82 SLGYSTITLQFRLGTDLDVALSEVQAAINAAQSlLPSEAPDPPVYRKAnsADTPIMYIGLTSEEMPRGqLTDYAERVLAP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 169 LLGQ-PNVSIVQVNGTRPYEVGIMVSDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIKTRGGDILVRTKNQAYTGLDFAQI 247
Cdd:NF033617 162 KLSQiNGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYEDL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 248 PLMTLPDGTTLLVGDIAAIDDGFAEYQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDG 327
Cdd:NF033617 242 VIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYDR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 328 TYYLKGRLEMMQKNMIAGVILVFIVLALFLR-FKLAFWVMIGIPLCFLGAFALMYMypaFAMTINMITLFGFILVLGIVV 406
Cdd:NF033617 322 TRFIRASIDEVESTLLEAVALVILVVFLFLRnLRATLIPAVTVPLSLIGTFAVMYL---FGFSINLLTLMALVLAIGLVV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 407 DDAIIIAESAWSSIEKHGHSVDSVIKGARKVALPATFGVLTTMAAFYPTLAISG---------PWTNAMAsmglvVIFCL 477
Cdd:NF033617 399 DDAIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGltgrlfrefAVTLAGA-----VIISG 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 478 MFSLVesklilpahLAHM---KLNKVEDTKNPLLRKVKQFFRGIRLAisgalkrfisnvYAPGLKKLLNYRGLTVLSFIC 554
Cdd:NF033617 474 IVALT---------LTPMmcsRLLKANEKPGRFARAVDRFFDGLTAR------------YGRGLKWVLKHRPLTLVVALA 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 555 LLLITTVGFIsggLVKTTMMPNVPGDGVFVEVKMAEGSTAEQTIRSITIVEEKLNEIHEEVKAKYGTGVKqhsvTWTNNN 634
Cdd:NF033617 533 TLALLPLLYV---FIPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVG----GNPGDN 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 635 TGaYMWTELVKSENMPINQYEFTDMWRDRVGQLPSVQEVSFGNGGPGGG------GVGYRLIGSDIDELQTVSEKIKTKL 708
Cdd:NF033617 606 TG-FGIINLKPWDERDVSAQEIIDRLRPKLAKVPGMDLFLFPLQDLPGGagsslpQYQVTLTPSDYDSLFTWAEKLKEKL 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 709 SEYDGVYDISDGLSGGKEEIVVDL-KPHGRNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLE 787
Cdd:NF033617 685 RKSPQFADVDSDLQDKGPELNVDIdRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALN 764
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 788 QMPIRTPDGDYVTFSDVATYKVSEGYSRISRIDGVRANRISADVSQQAAITPG-EVHMDMMQNVIPDilqehpSVKLVPG 866
Cdd:NF033617 765 QIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAiEALDQAAKELLPS------GISGSFQ 838
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 867 GPSEDEQVLQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVN 946
Cdd:NF033617 839 GAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKK 918
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 947 DSLLMVDFIGRA-REEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFATLITLV 1025
Cdd:NF033617 919 NGILMVEFANELqRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLF 998
|
....*...
gi 2100537107 1026 WVPCLYVL 1033
Cdd:NF033617 999 VLPVVYLL 1006
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
45-1033 |
7.40e-64 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 235.39 E-value: 7.40e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 45 FPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNS-SAREGSGSINIEVEEGYN--VASVldEVKIRID 121
Cdd:TIGR00915 35 YPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSsSDSDGSMTITLTFEQGTDpdIAQV--QVQNKLQ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 122 S-IPNLPDLAERPVIYENRMQRQ-VMWISVFGDAGERV---LKEYAN-DIKTELLGQPNVSIVQVNGTrPYEVGIMVSDY 195
Cdd:TIGR00915 113 LaTPLLPQEVQRQGVRVEKASSNfLMVIGLVSDDGSMTkedLSDYAAsNMVDPLSRLEGVGDVQLFGS-QYAMRIWLDPA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 196 QLRKYGLTLQQVAQAIRSYSLDLPSGTI---KTRGGDIL---VRTKNQAYTGLDFAQIPLMTLPDGTTLLVGDIAAIDDG 269
Cdd:TIGR00915 192 KLNSYQLTPADVISAISAQNAQISAGQLgglPAVPGQQLnatIIAQTRLQTPEQFENILLKVNTDGSQVRLKDVARVELG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 270 FAEYQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDGTYYLKGRLEMMQKNMIAGVILV 349
Cdd:TIGR00915 272 GENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLV 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 350 FIVLALFLR-FKLAFWVMIGIPLCFLGAFALMymyPAFAMTINMITLFGFILVLGIVVDDAIIIAESAWSSI-EKHGHSV 427
Cdd:TIGR00915 352 FLVMYLFLQnFRATLIPTIAVPVVLLGTFAVL---AAFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVMaEEGLPPK 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 428 DSVIKGARKV--ALPATFGVLttMAAFYPtLAISGPWTNAM-ASMGLVVIFCLMFSLVESKLILPAHLAHMkLNKVEDTK 504
Cdd:TIGR00915 429 EATRKSMGQIqgALVGIAMVL--SAVFVP-MAFFGGSTGAIyRQFSITIVSAMALSVLVALILTPALCATM-LKPIEKGE 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 505 NPllRKVKQFFrgirlaisGALKRF---ISNVYAPGLKKLLNYRGLTVLSFICLLLITTVGFISgglVKTTMMPNVPGDG 581
Cdd:TIGR00915 505 HH--EKKGGFF--------GWFNRMfdsSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR---LPTSFLPDEDQGV 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 582 VFVEVKMAEGSTAEQTIRSITIVEEK-LNEIHEEVKAKYgtgvkqhSVTWTNNNTgaymwtelvKSENMPINQYEFTDmW 660
Cdd:TIGR00915 572 FMTIVQLPAGATAERTQAVLAQVTKYlLAKEKANVESVF-------TVNGFSFAG---------RGQNMGMAFIRLKD-W 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 661 RDRVGQLPSVQEVSFGNGGPGGGGVGYRLI--------------GSDI---DELQTVSEKIKTKLSEYDGVYDISDGLS- 722
Cdd:TIGR00915 635 EERTGKENSVFAIAGRATGHFMQIKDAMVIafvppailelgnatGFDFflqDRAGLGHEALLQARNQLLGLAAQNPALTr 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 723 ---GGKE-----EIVVDlKPHGRNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPIRTP 794
Cdd:TIGR00915 715 vrpNGLEdepqlKIDID-REKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNA 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 795 DGDYVTFSDVATYKVSEGYSRISRIDGVRANRISAdvsqQAAitPGEVHMDMMqNVIPDILQEHPS-VKLVPGGPSEDEQ 873
Cdd:TIGR00915 794 SGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILG----SAA--PGVSTGQAM-AAMEAIAQKLPPgFGFSWTGMSYEER 866
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 874 VLQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVD 953
Cdd:TIGR00915 867 LSGSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVE 946
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 954 FIGRAREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMET--SLQAQLVIPMAVSlgFGIVFATLITLVWVPCLY 1031
Cdd:TIGR00915 947 FAKELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTgaGSGSQHAIGTGVF--GGMVTATVLAIFFVPLFY 1024
|
..
gi 2100537107 1032 VL 1033
Cdd:TIGR00915 1025 VV 1026
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
44-1047 |
1.81e-62 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 231.19 E-value: 1.81e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 44 VFPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSAREGSGSINIEVEEGYNVASVLDEVKIRIDSI 123
Cdd:TIGR00914 38 AVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 124 -PNLPDLAER---PV------IY----ENRMQRQVMWISVFGDAGERVLKEYAndIKTELLGQPNVSIVQVNGTRPYEVG 189
Cdd:TIGR00914 118 rDNLPEGVSPemgPIstglgeIFlytvEAEEGARKKDGGAYTLTDLRTIQDWI--IRPQLRTVPGVAEVNSIGGYVKQFL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 190 IMVSDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIKTRGGDILVRTKNQAYTGLDFAQIPLMTLpDGTTLLVGDIAAIDDG 269
Cdd:TIGR00914 196 VAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQSMDDIRNIVIATG-EGVPIRIRDVARVQIG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 270 FAEYQFISRFDGKDAVN----MRIQASLESddllIAEEVYAYLDKKQSELPHGISIDAWGDGTYYLKGRLEMMQKNMIAG 345
Cdd:TIGR00914 275 KELRTGAATENGKEVVLgtvfMLIGENSRT----VAQAVGDKLETINKTLPEGVEIVTTYDRSQLVDAAIATVKKNLLEG 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 346 VILVFIVLALFL-RFKLAFWVMIGIPLCFLGAFALMYMYpafAMTINMITLFGfiLVLGIVVDDAIIIAESAWSSIE--- 421
Cdd:TIGR00914 351 ALLVIVILFLFLgNIRAALIAATVIPLSLLITFIGMVFQ---GISANLMSLGA--LDFGLIVDGAVVIVENAHRRLAeaq 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 422 -KHGHSVD------SVIKGARKVALPATFGVLTTMAAFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESKLILPAHLAH 494
Cdd:TIGR00914 426 hHHGRQLTlkerlhEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVAL 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 495 MKLNKVEDTKNPLLrkvkqffrgirlaisgalkRFISNVYAPGLKKLLNYRgLTVLSFICLLLITTVGFISggLVKTTMM 574
Cdd:TIGR00914 506 FIRGKVAEKENRLM-------------------RVLKRRYEPLLERVLAWP-AVVLGAAAVSIVLVVWIAS--RVGGEFI 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 575 PNV-PGDGVFVEVKMAeGSTAEQTIRSITIVEEKLNEIHE--EVKAKYGTG-----------------VKQHSvTWTN-- 632
Cdd:TIGR00914 564 PSLnEGDLAYQALRIP-GTSLAQSVAMQQTLEKLIKSFPEvaRVFAKTGTAeiatdpmppnasdtyiiLKPES-QWPEgk 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 633 NNTGAYMWTELVKSENMPINQYEFTDMWRDRVGQLPSvqevsfgnggPGGGGVGYRLIGSDIDELQTVSEKIKTKLSEYD 712
Cdd:TIGR00914 642 KTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELIS----------GVRSDVAVKVFGDDLDDLDATAEKISAVLKGVP 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 713 GVYDISDGLSGGKEEIVVDL-KPHGRNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPI 791
Cdd:TIGR00914 712 GAADVKVEQTTGLPYLTVEIdREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPI 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 792 RTPDG-----DYVTFSDVATYKVSEGYSRISRIDGVRANRISADVSQQAaitpgevhmdmMQNVIPDILQE-HPSVKLVP 865
Cdd:TIGR00914 792 PLPLSedarkQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRD-----------LGSFVDDAKKAiAEQVKLPP 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 866 G------GPSEDEQVLQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIA 939
Cdd:TIGR00914 861 GywitwgGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIA 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 940 LSGVVVNDSLLMVDFIGRAREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFA 1019
Cdd:TIGR00914 941 LSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITA 1020
|
1050 1060
....*....|....*....|....*...
gi 2100537107 1020 TLITLVWVPCLYvlmgntrDWFLKRDAK 1047
Cdd:TIGR00914 1021 TLLTLFVLPALY-------RLVHRRRHK 1041
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
45-1035 |
2.75e-52 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 199.69 E-value: 2.75e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 45 FPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSAREGSGSINIEVEEGYNVASVLDEVKIRIDSI- 123
Cdd:PRK09577 35 YPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTFKQGVNADLAAVEVQNRLKTVe 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 124 PNLPDLAERPVIY----ENRMQRQVMWISVFGDAGERVLKEYAN-DIKTELLGQPNVSIVQVNGTRpYEVGIMVSDYQLR 198
Cdd:PRK09577 115 ARLPEPVRRDGIQvekaADNIQLIVSLTSDDGRLTGVELGEYASaNVLQALRRVEGVGKVQFWGAE-YAMRIWPDPVKLA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 199 KYGLTLQQVAQAIRSYSLDLPSGTIKTRG----GDILVRTKNQA--YTGLDFAQIPLMTLPDGTTLLVGDIAAIDDGFAE 272
Cdd:PRK09577 194 ALGLTASDIASAVRAHNARVTIGDIGRSAvpdsAPIAATVFADAplKTPEDFGAIALRARADGSALYLRDVARIEFGGND 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 273 YQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDGTYYLKGRLEMMQKNMIAGVILVFIV 352
Cdd:PRK09577 274 YNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPGVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLV 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 353 LALFLR-FKLAFWVMIGIPLCFLGAFALMYmypAFAMTINMITLFGFILVLGIVVDDAIIIAESAWSSIEKHGHS-VDSV 430
Cdd:PRK09577 354 MFLFMQnFRATLIPTLVVPVALLGTFGVML---AAGFSINVLTMFGMVLAIGILVDDAIVVVENVERLMVEEGLSpYDAT 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 431 IKGARKV--ALPATFGVLTTMaaFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESKLILPAHLAhmklnkvedtknPLL 508
Cdd:PRK09577 431 VKAMKQIsgAIVGITVVLTSV--FVPMAFFGGAVGNIYRQFALSLAVSIGFSAFLALSLTPALCA------------TLL 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 509 RKVKQFFRGIRlAISGALKRFISNV---YAPGLKKLLN--YRGLTVLSficlLLITTVGFISGGLvKTTMMPNVPGDGVF 583
Cdd:PRK09577 497 KPVDGDHHEKR-GFFGWFNRFVARStqrYATRVGAILKrpLRWLVVYG----ALTAAAALLFTRL-PTAFLPDEDQGNFM 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 584 VEVKMAEGSTAEQTIRSITIVEEKLNEiHEEVKAKYGTGvkQHSVTWTNNNTGAYM-----WTE----------LVKSEN 648
Cdd:PRK09577 571 VMVIRPQGTPLAETMQSVREVESYLRR-HEPVAYTFALG--GFNLYGEGPNGGMIFvtlkdWKErkaardhvqaIVARIN 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 649 MPINQYEFTDMWRDRVGQLPSVQEVSfgnggpgggGVGYRLI---GSDIDELQTVSEKIKTKLSEYDGVYDISdgLSGGK 725
Cdd:PRK09577 648 ERFAGTPNTTVFAMNSPALPDLGSTS---------GFDFRLQdrgGLGYAAFVAAREQLLAEGAKDPALTDLM--FAGTQ 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 726 EEIVVDL---KPHGRNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPIRTPDGDYVTFS 802
Cdd:PRK09577 717 DAPQLKLdidRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEMVPLA 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 803 DVATYKVSEGYSRISRIDGVRANRISAdvsqQAAitPGEVHMDMMQNVipdilqEHPSVKLVPG------GPSEDEQVLQ 876
Cdd:PRK09577 797 AFATLHWTLGPPQLTRYNGYPSFTING----SAA--PGHSSGEAMAAI------ERIAATLPAGigyawsGQSFEERLSG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 877 DEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVDFIG 956
Cdd:PRK09577 865 AQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAK 944
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 957 RAREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQ--AQLVIPMAVsLGfGIVFATLITLVWVPCLYVLM 1034
Cdd:PRK09577 945 DLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAAsgAQIAIGTGV-LG-GVITATVLAVFLVPLFFVVV 1022
|
.
gi 2100537107 1035 G 1035
Cdd:PRK09577 1023 G 1023
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
15-1034 |
3.15e-52 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 199.68 E-value: 3.15e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 15 FARNSVAANLLMIAIIVAGIIGISKLRQQVFPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSARE 94
Cdd:PRK09579 7 FIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 95 GSGSINIEVEEGYNVASVLDEVKIRIDSIPN-LPDLAERPVIY-ENRMQRQVMWISVFGD--AGERVLKEYANDIKTELL 170
Cdd:PRK09579 87 NFSIISIYARIGADSDRLFTELLAKANEVKNqLPQDAEDPVLSkEAADASALMYISFYSEemSNPQITDYLSRVIQPKLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 171 GQPNVSIVQVNGTRPYEVGIMVSDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIKTRggdiLVRTKNQAYTGLD----FAQ 246
Cdd:PRK09579 167 TLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGE----YVVTSINASTELKsaeaFAA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 247 IPLMTLPDgTTLLVGDIAAIDDGFAEYQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGD 326
Cdd:PRK09579 243 IPVKTSGD-SRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAYD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 327 GTYYLKGRLEMMQKNMIAGVILVFIVLALFL-RFKLAFWVMIGIPLCFLGAFALMYMypaFAMTINMITLFGFILVLGIV 405
Cdd:PRK09579 322 ATLFIQASIDEVVKTLGEAVLIVIVVVFLFLgALRSVLIPVVTIPLSMIGVLFFMQM---MGYSINLLTLLAMVLAIGLV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 406 VDDAIIIAESAWSSIEKHGHSVDSVIKGARKVALPATFGVLTTMAAFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESK 485
Cdd:PRK09579 399 VDDAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVAL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 486 LILPAHLAhmKLNKVEDTKNPLLRKVKQFFRGIRlaisgalKRfisnvYAPGLKKLLNYR------GLTVLSFICLLLIT 559
Cdd:PRK09579 479 TLSPMMCA--LLLRHEENPSGLAHRLDRLFERLK-------QR-----YQRALHGTLNTRpvvlvfAVIVLALIPVLLKF 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 560 TvgfisgglvKTTMMPNVPGDGVFvevkMAEGSTAEQTIRSITIVEEKLNEIHEEVkAKYGTGVKQHSVTWTNNNTGAYM 639
Cdd:PRK09579 545 T---------QSELAPEEDQGIIF----MMSSSPQPANLDYLNAYTDEFTPIFKSF-PEYYSSFQINGFNGVQSGIGGFL 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 640 ---WTELVKSenmpinQYEFTDMWRDRVGQLPSVQEVSFGNGGPGGGGVGYRL-----IGSDIDELQTVSEKIKTKLSEY 711
Cdd:PRK09579 611 lkpWNERERT------QMELLPLVQAKLEEIPGLQIFGFNLPSLPGTGEGLPFqfvinTANDYESLLQVAQRVKQRAQES 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 712 DGVYDISDGLSGGKEEIVVDL-KPHGRNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMP 790
Cdd:PRK09579 685 GKFAFLDIDLAFDKPEVVVDIdRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYY 764
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 791 IRTPDGDYVTFSDVatykvsegysrISRIDGVRANRISADVSQQAAITPGE--VHMDMMQNVIPDILQEHpsvklVPGGP 868
Cdd:PRK09579 765 VKNEQGQLLPLSTL-----------ITLSDRARPRQLNQFQQLNSAIISGFpiVSMGEAIETVQQIAREE-----APEGF 828
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 869 SED-----EQVLQDEMALGGL--IALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGhLLLGLD-LSMFSLFGIIAL 940
Cdd:PRK09579 829 AFDyagasRQYVQEGSALWVTfgLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIP-LFLGVSsMNIYTQVGLVTL 907
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 941 SGVVVNDSLLMVDFIGRAREE-GMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFA 1019
Cdd:PRK09579 908 IGLISKHGILIVEFANQLRHEqGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIG 987
|
1050
....*....|....*
gi 2100537107 1020 TLITLVWVPCLYVLM 1034
Cdd:PRK09579 988 TLFTLFVLPCIYTLL 1002
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
45-1034 |
1.10e-47 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 185.42 E-value: 1.10e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 45 FPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNS-SAREGSGSINIEVEEGYNVASVLDEVKIRIDS- 122
Cdd:PRK10555 35 YPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSqSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSa 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 123 IPNLPDLAERPVIYENRMQRQ----VMWISVFGDAGERVLKEY-ANDIKTELLGQPNVSIVQVNGTRpYEVGIMVSDYQL 197
Cdd:PRK10555 115 MRKLPQAVQNQGVTVRKTGDTniltIAFVSTDGSMDKQDIADYvASNIQDPLSRVNGVGDIDAYGSQ-YSMRIWLDPAKL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 198 RKYGLTLQQVAQAIRSYSLDLPSG------TIKTRGGDILVRTKNQAYTGLDFAQIPLMTLPDGTTLLVGDIAAIDDGFA 271
Cdd:PRK10555 194 NSFQMTTKDVTDAIESQNAQIAVGqlggtpSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEVTLGDVATVELGAE 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 272 EYQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDGTYYLKGRLEMMQKNMIAGVILVFI 351
Cdd:PRK10555 274 KYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFL 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 352 VLALFLR-FKLAFWVMIGIPLCFLGAFALMYmypAFAMTINMITLFGFILVLGIVVDDAIIIAESAWSSIEKHGHSVDSV 430
Cdd:PRK10555 354 VMYLFLQnFRATLIPTIAVPVVLMGTFSVLY---AFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLTPREA 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 431 IKGARKVALPATFGVLTTMAAFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESKLILPAHLAHMKLNKVEDTKNpllRK 510
Cdd:PRK10555 431 TRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSVLVAMILTPALCATLLKPLKKGEH---HG 507
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 511 VKQFFRGIRLAISGALKRfisnvYAPGLKKLLNYRGLTVLSFICLLLITTVGFISgglVKTTMMPnVPGDGVFV-EVKMA 589
Cdd:PRK10555 508 QKGFFGWFNRMFNRNAER-----YEKGVAKILHRSLRWILIYVLLLGGMVFLFLR---LPTSFLP-LEDRGMFTtSVQLP 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 590 EGSTAEQTIRSITIVE------EKLNEihEEVKAKYGTGvkqhsvTWTNNNTGAYM------WTELVKSENMPINQYE-- 655
Cdd:PRK10555 579 SGSTQQQTLKVVEKVEkyyfthEKDNV--MSVFATVGSG------PGGNGQNVARMfirlkdWDERDSKTGTSFAIIEra 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 656 ---FTDMWRDRV--GQLPSV----QEVSFGNGGPGGGGVGYRLIGSDIDELQTVSEKiKTKLS--EYDGVYDISdglsgg 724
Cdd:PRK10555 651 tkaFNKIKEARViaSSPPAIsglgSSAGFDMELQDHAGAGHDALMAARNQLLALAAK-NPELTrvRHNGLDDSP------ 723
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 725 keEIVVDLKPH-GRNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPIRTPDGDYVTFSD 803
Cdd:PRK10555 724 --QLQIDIDQRkAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSA 801
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 804 VATYKVSEGYSRISRIDGVRANRISADVSQqaAITPGEVhMDMMQNVIpdilQEHPS-VKLVPGGPSEDEQVLQDEMALG 882
Cdd:PRK10555 802 FATSRWETGSPRLERYNGYSAVEIVGEAAP--GVSTGTA-MDIMESLV----KQLPNgFGLEWTAMSYQERLSGAQAPAL 874
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 883 GLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVDFIGRAREEG 962
Cdd:PRK10555 875 YAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKG 954
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2100537107 963 MSRIDAAVNAGTQRFRAIILTSLTTFFGLLPitMETSLQAQLVIPMAVSLGF--GIVFATLITLVWVPCLYVLM 1034
Cdd:PRK10555 955 HDLFEATLHASRQRLRPILMTSLAFIFGVLP--MATSTGAGSGSQHAVGTGVmgGMISATILAIFFVPLFFVLV 1026
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
39-1034 |
6.54e-45 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 176.63 E-value: 6.54e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 39 KLRQQVFPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSA-REGSGSINIEVEEGYN--VASVLDE 115
Cdd:PRK15127 29 KLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQITLTFESGTDadIAQVQVQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 116 VKIRIdSIPNLP-DLAERPVIYENRMQRQVMWISVFGDAG----ERVLKEYANDIKTELLGQPNVSIVQVNGTRpYEVGI 190
Cdd:PRK15127 109 NKLQL-AMPLLPqEVQQQGVSVEKSSSSFLMVVGVINTDGtmtqEDISDYVAANMKDPISRTSGVGDVQLFGSQ-YAMRI 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 191 MVSDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIktrGGDILVRTKNQ-----AYTGL----DFAQIPLMTLPDGTTLLVG 261
Cdd:PRK15127 187 WMNPNELNKFQLTPVDVINAIKAQNAQVAAGQL---GGTPPVKGQQLnasiiAQTRLtsteEFGKILLKVNQDGSRVRLR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 262 DIAAIDDGFAEYQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDGTYYLKGRLEMMQKN 341
Cdd:PRK15127 264 DVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKT 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 342 MIAGVILVFIVLALFLR-FKLAFWVMIGIPLCFLGAFALMymyPAFAMTINMITLFGFILVLGIVVDDAIIIAESAWSSI 420
Cdd:PRK15127 344 LVEAIILVFLVMYLFLQnFRATLIPTIAVPVVLLGTFAVL---AAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 421 EKHGHSVDSVIKGARKVALPATFGVLTTMAAFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESKLILPAHLAHMKLNKV 500
Cdd:PRK15127 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPI 500
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 501 EdtKNPLLRKVKQFFrgirlaisGALKRFI---SNVYAPGLKKLLNYRGLTVLSFICLLLITTVGFISgglVKTTMMPNv 577
Cdd:PRK15127 501 A--KGDHGEGKKGFF--------GWFNRMFeksTHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFVR---LPSSFLPD- 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 578 PGDGVFV-EVKMAEGSTAEQTirsitivEEKLNEIHEEVKAKYGTGVKQhsvTWTNNNTGAYMwtelvKSENMPINQYEF 656
Cdd:PRK15127 567 EDQGVFLtMVQLPAGATQERT-------QKVLNEVTDYYLTKEKNNVES---VFAVNGFGFAG-----RGQNTGIAFVSL 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 657 TDmWRDRVG---QLPSVQEVSFGNGGPGGGGVGYRLIGSDIDELQTVS----EKIKTKLSEYDGVYDISD---GLSGGKE 726
Cdd:PRK15127 632 KD-WADRPGeenKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATgfdfELIDQAGLGHEKLTQARNqllGEAAKHP 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 727 EIVVDLKPHG----------------RNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMP 790
Cdd:PRK15127 711 DMLVGVRPNGledtpqfkididqekaQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWY 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 791 IRTPDGDYVTFSDVATYKVSEGYSRISRIDGVRanriSADVSQQAAitPGEVHMDMMQnvipdiLQEHPSVKLVPG---- 866
Cdd:PRK15127 791 VRAADGQMVPFSAFSSSRWEYGSPRLERYNGLP----SMEILGQAA--PGKSTGEAME------LMEELASKLPTGvgyd 858
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 867 --GPSEDEQVLQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVV 944
Cdd:PRK15127 859 wtGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLS 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 945 VNDSLLMVDFIGRARE-EGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFATLIT 1023
Cdd:PRK15127 939 AKNAILIVEFAKDLMDkEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLA 1018
|
1050
....*....|.
gi 2100537107 1024 LVWVPCLYVLM 1034
Cdd:PRK15127 1019 IFFVPVFFVVV 1029
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
38-1051 |
3.87e-37 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 151.80 E-value: 3.87e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 38 SKLRQQVFPdmvvnSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSAREGSGSINIEVEEGYNVASVLDEVK 117
Cdd:PRK10614 35 APLPQVDFP-----VIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILQFDFDRDINGAARDVQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 118 IRIDSIPNL--PDLAERPVIYE-NRMQRQVMWISVFGDA-GERVLKEYANDIKTELLGQPN-VSIVQVNGTRPYEVGIMV 192
Cdd:PRK10614 110 AAINAAQSLlpSGMPSRPTYRKaNPSDAPIMILTLTSDTySQGQLYDFASTQLAQTISQIDgVGDVDVGGSSLPAVRVGL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 193 SDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIKTRGGDILVRTKNQAYTGLDFAQIpLMTLPDGTTLLVGDIAAIDDGFAE 272
Cdd:PRK10614 190 NPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPL-IIHYNNGAAVRLGDVATVTDSVQD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 273 YQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDGTYYLKGRLEMMQKNMIAGVILVFIV 352
Cdd:PRK10614 269 VRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIAQDRSPTIRASLEEVEQTLAISVALVILV 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 353 LALFLRFKLAFWV-MIGIPLCFLGAFALMYMypaFAMTINMITLFGFILVLGIVVDDAIIIAESAWSSIEKHGHSVDSVI 431
Cdd:PRK10614 349 VFLFLRSGRATLIpAVAVPVSLIGTFAAMYL---CGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAAL 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 432 KGARKVALPATFGVLTTMAAFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESKLILPAHLAHMkLNKVEDTKNPLLRKv 511
Cdd:PRK10614 426 QGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMMCAWL-LKSSKPREQKRLRG- 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 512 kqfFRGIRLAISGAlkrfisnvYAPGLKKLLNYRGLTVLSFICLLLITTVGFISgglVKTTMMPNvPGDGVFVEVKMAEG 591
Cdd:PRK10614 504 ---FGRMLVALQQG--------YGRSLKWVLNHTRWVGVVLLGTIALNVWLYIS---IPKTFFPE-QDTGRLMGFIQADQ 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 592 STAEQTIRSItiVEEKLNEIHEEVKAKYGTGVKQHSVTwtnnNTGAyMWTELVKSENMPINQYEFTDMWRDRVGQLP--- 668
Cdd:PRK10614 569 SISFQAMRGK--LQDFMKIIRDDPAVDNVTGFTGGSRV----NSGM-MFITLKPLSERSETAQQVIDRLRVKLAKEPgan 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 669 ----SVQEVSfGNGGPGGGGVGYRLIGSDIDELQTVSEKIKTKLSEYDGVYDI-SDGLSGGKEEIVVDLKPHGRNLGLTV 743
Cdd:PRK10614 642 lflmAVQDIR-VGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVnSDQQDKGAEMALTYDRDTMARLGIDV 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 744 QGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMPIRTPDGDYVTFSDVATYKVS--------EGYSR 815
Cdd:PRK10614 721 QAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPAnaplsvnhQGLSA 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 816 ISRIdgvrANRISADVSQQAAItpGEVHMDMMQNVIPdilqehPSVKLVPGGPSEDEQVLQDEMALGGLIALLMIYGLMA 895
Cdd:PRK10614 801 ASTI----SFNLPTGKSLSDAS--AAIERAMTQLGVP------STVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLG 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 896 IPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVDFIGRA-REEGMSRIDAAVNAGT 974
Cdd:PRK10614 869 ILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAqRNGNLTAQEAIFQACL 948
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2100537107 975 QRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFATLITLVWVPCLYVLMGNTRDWFLKRDAKSLEA 1051
Cdd:PRK10614 949 LRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
20-1051 |
1.09e-33 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 140.64 E-value: 1.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 20 VAANLLMIAIIVAGIIGISKLRQQVFPDMVVNSISVQVPYPGAAPQEVEEGIIILIEENIKEIEGIKKLNSSAREGSGSI 99
Cdd:PRK10503 21 VATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 100 NIEVEEGYNVASVLDEVKIRIDSIPN-LPDLAERPVIYE--NRMQRQVMWISVFGDAgeRVLKEYANDIKTELLGQpnvs 176
Cdd:PRK10503 101 TLQFQLTLPLDVAEQEVQAAINAATNlLPSDLPNPPVYSkvNPADPPIMTLAVTSTA--MPMTQVEDMVETRVAQK---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 177 IVQVNGT---------RPyEVGIMVSDYQLRKYGLTLQQVAQAIRSYSLDLPSGTIKTRGGDILVRTKNQAYTGLDFAQI 247
Cdd:PRK10503 175 ISQVSGVglvtlsggqRP-AVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 248 pLMTLPDGTTLLVGDIAAIDDGFAEYQFISRFDGKDAVNMRIQASLESDDLLIAEEVYAYLDKKQSELPHGISIDAWGDG 327
Cdd:PRK10503 254 -IIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDR 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 328 TYYLKGRLEMMQKNMIAGVILVFIVLALFLRFKLAFWV-MIGIPLCFLGAFALMYMypaFAMTINMITLFGFILVLGIVV 406
Cdd:PRK10503 333 TTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIpGVAVPLSLIGTFAVMVF---LDFSINNLTLMALTIATGFVV 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 407 DDAIIIAESAWSSIEKHGHSVDSVIKGARKVALPATFGVLTTMAAFYPTLAISGPWTNAMASMGLVVIFCLMFSLVESKL 486
Cdd:PRK10503 410 DDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLT 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 487 ILPAHLAHMKLNKVEDTKNPLLRKVKQFFrgirlaisgalKRFISnVYAPGLKKLLNYRGLTVLSFICLLLITTV----- 561
Cdd:PRK10503 490 LTPMMCARMLSQESLRKQNRFSRASERMF-----------DRVIA-AYGRGLAKVLNHPWLTLSVALSTLLLTVLlwifi 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 562 ----------GFISGGL-----------------VKTTMM--PNVPGDGVFVEVkmaEGSTAEQTIRSITIVEEKLNEIH 612
Cdd:PRK10503 558 pkgffpvqdnGIIQGTLqapqsssfanmaqrqrqVADVILqdPAVQSLTSFVGV---DGTNPSLNSARLQINLKPLDERD 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 613 EEVKAkygtgVKQHSVTWTNNNTGAYMWTELVksENMPI------NQYEFTdmwrdrvgqlpsvqevsfgnggpggggvg 686
Cdd:PRK10503 635 DRVQK-----VIARLQTAVAKVPGVDLYLQPT--QDLTIdtqvsrTQYQFT----------------------------- 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 687 yrLIGSDIDELQTVSEKIKTKLSEYDGVYDI-SDGLSGGKEEIV-VDLKPHGRnLGLTVqglsTQVRNAFYGAEAQRFLR 764
Cdd:PRK10503 679 --LQATSLDALSTWVPKLMEKLQQLPQLSDVsSDWQDKGLVAYVnVDRDSASR-LGISM----ADVDNALYNAFGQRLIS 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 765 ----DTEEVKVFVRYPLEDRRSIGNLEQMPIRTPDGDYVTFSDVATYKVSEGYSRISRIDGVRANRISADVSQQA----- 835
Cdd:PRK10503 752 tiytQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGYslgda 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 836 --AITPGEVHMDMMQNVipdILQEHPSvklvpggpsedeqVLQDEMALGGLI-----ALLMIYGLMAIPLKSYVKPAVVM 908
Cdd:PRK10503 832 vqAIMDTEKTLNLPADI---TTQFQGS-------------TLAFQSALGSTVwlivaAVVAMYIVLGVLYESFIHPITIL 895
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 909 SAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLLMVDFIGRA-REEGMSRIDAAVNAGTQRFRAIILTSLTT 987
Cdd:PRK10503 896 STLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAeREQGMSPRDAIYQACLLRFRPILMTTLAA 975
|
1050 1060 1070 1080 1090 1100
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2100537107 988 FFGLLPITMETSLQAQLVIPMAVSLGFGIVFATLITLVWVPCLYVLMGNTRDWFLKRDAKSLEA 1051
Cdd:PRK10503 976 LLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEE 1039
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
327-1034 |
1.19e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 78.75 E-value: 1.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 327 GTYYLKGRL-EMMQKNM--IAGVILVFIVLALFLRFKLAFWVMIGIPLCFLGAFALMYMYPAFAMTINMITLFGFILVLG 403
Cdd:COG1033 204 GFPVLRGDIaEAIQSDLaiFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 404 IVVDDAIIIAESAWSSIEKHGHSVDSVIKGARKVALPATFGVLTTMAAFYpTLAISGpwTNAMASMGLVVIFCLMFSLVE 483
Cdd:COG1033 284 IGIDYGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFL-SLLFSD--IPPIRDFGIVAAIGVLLAFLT 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 484 SKLILPAHLAHMKLNKVEDTKNPLLRKVKQFFRGIRlaisgalkRFIsnvyapglkklLNYRGLTVLSFICLLLITTVGf 563
Cdd:COG1033 361 SLTLLPALLSLLPRPKPKTRRLKKPPELGRLLAKLA--------RFV-----------LRRPKVILVVALVLAVVSLYG- 420
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 564 isgglvkttmmpnvpgdgvfvevkmaegstaeqtirsitiveeklneiheevkakyGTGVKqhsvtwTNNNTGAYMWtel 643
Cdd:COG1033 421 --------------------------------------------------------ISRLK------VEYDFEDYLP--- 435
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 644 vksENMPINQ-YEFTDmwrDRVGQLPSVqEVSFGNGGPGGGgvgyrligSDIDELQTVsEKIKTKLSEYDGVYDIsdgls 722
Cdd:COG1033 436 ---EDSPIRQdLDFIE---ENFGGSDPL-EVVVDTGEPDGL--------KDPEVLKEI-DRLQDYLESLPEVGKV----- 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 723 ggkeeivvdlkphgrnlgLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPLEDRRSIGNLEQMpiRTPDGDYVTFS 802
Cdd:COG1033 495 ------------------LSLADLVKELNQALNEGDPKYYALPESRELLAQLLLLLSSPPGDDLSRF--VDEDYSAARVT 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 803 dvATYKVSEGySRISRIdgvrANRISADVSQQAAITPGEVHM----DMMQNVIpdilqehpsvklvpggpsedeQVLQDE 878
Cdd:COG1033 555 --VRLKDLDS-EEIKAL----VEEVRAFLAENFPPDGVEVTLtgsaVLFAAIN---------------------ESVIES 606
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 879 MALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGII---GAMFghlLLGLDLSMFSLFgIIALS-GVVVNDSLLMVDF 954
Cdd:COG1033 607 QIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILltfGLMG---LLGIPLNIATAV-VASIAlGIGVDYTIHFLSR 682
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 955 IGRAREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITM-ETSLQAQlvipMAVSLGFGIVFATLITLVWVPCLYVL 1033
Cdd:COG1033 683 YREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFsSFPPLAD----FGLLLALGLLVALLAALLLLPALLLL 758
|
.
gi 2100537107 1034 M 1034
Cdd:COG1033 759 L 759
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
870-1039 |
2.78e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 74.13 E-value: 2.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 870 EDEQVLQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGII---GAMFghlLLGLDLSMFSLFGIIALSGVVVN 946
Cdd:COG1033 211 DIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIwtlGLMG---LLGIPLSPLTILVPPLLLAIGID 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 947 DSLLMVDFIGRAREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLpiTMETSlQAQLVIPMAVSLGFGIVFATLITLVW 1026
Cdd:COG1033 288 YGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFL--SLLFS-DIPPIRDFGIVAAIGVLLAFLTSLTL 364
|
170
....*....|...
gi 2100537107 1027 VPCLYVLMGNTRD 1039
Cdd:COG1033 365 LPALLSLLPRPKP 377
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
147-490 |
2.59e-12 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 71.21 E-value: 2.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 147 ISVFGDAGErVLKEYANDIKTELLGQP---NVSIVQVNGTRPYEVGImvsDYQ-LRKYGLTLQQVAQAIRSysldlpsgt 222
Cdd:COG3696 677 VKIFGDDLD-VLRRLAEQIEAVLKTVPgaaDVQVERVTGLPQLDIRI---DRDaAARYGLNVADVQDVVET--------- 743
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 223 ikTRGG-------------DILVRTKNQAYTGLD-FAQIPLMTlPDGTTLLVGDIAAID--DGFAeyqFISRFDGKdavn 286
Cdd:COG3696 744 --AIGGkavgqvyegerrfDIVVRLPEELRDDPEaIRNLPIPT-PSGAQVPLSQVADIEvvEGPN---QISRENGR---- 813
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 287 mR---IQASLESDDL---------LIAEEVyayldkkqsELPHGISIDaWGdGTY-YLKgrlEMMQKNMIAGVI-LVFIV 352
Cdd:COG3696 814 -RrivVQANVRGRDLgsfvaeaqaKVAEQV---------KLPPGYYIE-WG-GQFeNLQ---RATARLAIVVPLaLLLIF 878
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 353 LALFLRF---KLAFWVMIGIPLCFLGAFALMYMYpafAMTINMITLFGFILVLGIVVDDAIIIAeSAWSSIEKHGHSV-D 428
Cdd:COG3696 879 LLLYLAFgsvRDALLILLNVPFALIGGVLALWLR---GMPLSVSAGVGFIALFGVAVLNGVVLV-SYINQLRAEGLDLrE 954
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2100537107 429 SVIKGARKVALPATFGVLTTMAAFYPtLAIS-GPWTNAMASMGLVVIFCLMFSLVESKLILPA 490
Cdd:COG3696 955 AIIEGALERLRPVLMTALVAALGLLP-MALStGPGSEVQRPLATVVIGGLITSTLLTLLVLPA 1016
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
700-1034 |
9.73e-12 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 69.25 E-value: 9.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 700 VSEKIKTKLSEYDGVYDISdgLSGGKE-EIVVDLKPHG-RNLGLTVQGLSTQVRNAFYGAEAQRFLRDTEEVKVFVRYPL 777
Cdd:pfam00873 157 ADTNIKPQLSRVPGVGDVQ--LFGGSEyAMRIWLDPQKlARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 778 EdrrSIGNLEQMPIRTPDGDYVTFSDVATYKV-SEGYSRISRIDGVRANRISadVSQQAAITPGEVhMDMMQNVIPDILQ 856
Cdd:pfam00873 235 Q---SAEDFEKIIVKNQDGSPVRLRDVATVELgSELYRGFATFNGKPAVGLG--VQKLPGANAIET-ADAVRAKLAELKP 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 857 EHP-SVKLVPggPSEDEQVLQ---DEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMF 932
Cdd:pfam00873 309 TFPqGVEIVV--VYDTTPFIRasiEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTL 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 933 SLFGIIALSGVVVNDSLLMVDFIGR-AREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVS 1011
Cdd:pfam00873 387 TLGGLVLAIGLVVDDAIVVVENIERvLEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAIT 466
|
330 340
....*....|....*....|...
gi 2100537107 1012 LGFGIVFATLITLVWVPCLYVLM 1034
Cdd:pfam00873 467 IVLAILLSVLVALTLTPALCATL 489
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
231-490 |
2.69e-10 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 64.50 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 231 LVRTKNQAYTGLDFAQIPLMTLPDGTTLLVGDIAAIDDGFAEyQFISrFDGKDA-VNMRIqASLESDDLL-IAEEVYAYL 308
Cdd:COG1033 500 LVKELNQALNEGDPKYYALPESRELLAQLLLLLSSPPGDDLS-RFVD-EDYSAArVTVRL-KDLDSEEIKaLVEEVRAFL 576
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 309 DKKQSelPHGISIDAWGDGTYYLKGrLEMMQKNMIAGVILVFIVLALFL-----RFKLAFWVMIGIPLCFLGAFALMYMy 383
Cdd:COG1033 577 AENFP--PDGVEVTLTGSAVLFAAI-NESVIESQIRSLLLALLLIFLLLllafrSLRLGLISLIPNLLPILLTFGLMGL- 652
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 384 paFAMTINMITLFGFILVLGIVVDDAI-----IIAEsawssIEKHGHSVDSVIKGARKVALPATFGVLTTMAAFYpTLAI 458
Cdd:COG1033 653 --LGIPLNIATAVVASIALGIGVDYTIhflsrYREE-----RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFG-VLLF 724
|
250 260 270
....*....|....*....|....*....|..
gi 2100537107 459 SGpwTNAMASMGLVVIFCLMFSLVESKLILPA 490
Cdd:COG1033 725 SS--FPPLADFGLLLALGLLVALLAALLLLPA 754
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
346-493 |
4.00e-07 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 54.23 E-value: 4.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 346 VILVFIVLALFLRFKLAFWVMIGIPLCFlgafalmymypafamtINMITLfgfILVLGIVVDDAIIIAEsAWSSIEKHGH 425
Cdd:TIGR03480 739 VLLVLAPLLLAGLLTVAAMVLLGIPFNF----------------ANIIAL---PLLLGLGVDFGIYMVH-RWRNGVDSGN 798
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2100537107 426 SVDSvikgarKVALPATFGVLTTMAAFyPTLAISG-PwtnAMASMGLVVIFCLMFSLVESKLILPAHLA 493
Cdd:TIGR03480 799 LLQS------STARAVFFSALTTATAF-GSLAVSShP---GTASMGILLSLGLGLTLLCTLIFLPALLG 857
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
906-1047 |
5.91e-06 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 50.41 E-value: 5.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 906 VVMSAIPFGIIGAMFGHLLLGLDLSMFSLfGIIALS-GVVVNDSLLMVDFIGRAREEgmsriDAAVNAGTQRFRAIILTS 984
Cdd:COG3696 364 IVALAIPLSLLFAFIVMRLFGISANLMSL-GGLAIDfGIIVDGAVVMVENILRRLEE-----NRAAGTPRERLEVVLEAA 437
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2100537107 985 L----TTFFGL-------LPITMETSLQAQLVIPMAVSLGFGIVFATLITLVWVPclyVLMGntrdWFLKRDAK 1047
Cdd:COG3696 438 RevrrPIFFATliiilvfLPIFTLEGVEGKLFRPMALTVIFALLGALLLSLTLVP---VLAS----LLLRGKVP 504
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
879-1048 |
6.93e-06 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 49.21 E-value: 6.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 879 MALGGLIALLMIYGLMAIPLKSYVKPA-----VVMS-AIPFGIIGAMFGHLLLGLDLSMFSLFGIIALsGVVVNDSLLmv 952
Cdd:pfam03176 144 LGLIEAVTLVVIFIILLIVYRSVVAALlplltVGLSlGAAQGLVAILAHILGIGLSTFALNLLVVLLI-AVGTDYALF-- 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 953 dFIGRAREE---GMSRIDAAVNAGTQRFRAII---LTSLTTFFGLLPITMeTSLQAqlvipMAVSLGFGIVFATLITLVW 1026
Cdd:pfam03176 221 -LVSRYREElraGEDREEAVIRAVRGTGKVVTaagLTVAIAMLALSFARL-PVFAQ-----VGPTIAIGVLVDVLAALTL 293
|
170 180
....*....|....*....|..
gi 2100537107 1027 VPCLYVLMGNTRDWFLKRDAKS 1048
Cdd:pfam03176 294 LPALLALLGRWGLWPPKRDRTA 315
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
344-490 |
9.24e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 49.85 E-value: 9.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 344 AGVILVFIVLALFLR-FKLAFWVMIGIPLCFLGAFALMYmypAFAMTINMITLFGFILVLGIVVDDAIIIAESAWSsiek 422
Cdd:COG4258 647 LALLLILLLLLLRLRsLRRALRVLLPPLLAVLLTLAILG---LLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLD---- 719
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2100537107 423 hghsvdsviKGARKVALPA-TFGVLTTMAAFyPTLAISGpwTNAMASMGLVVIFCLMFSLVESKLILPA 490
Cdd:COG4258 720 ---------KGELARTLLSiLLAALTTLLGF-GLLAFSS--TPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
338-525 |
1.37e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 49.23 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 338 MQKNMIAGVILVFIVLALFLR-FKLAFWVMIG--IPLCFLGAFALMymypaFAMTINMITLFGFILVLGIVVDDAIIIAE 414
Cdd:TIGR03480 271 ATVAGLLSFVLVLVLLWLALRsPRLVFAVLVTliVGLILTAAFATL-----AVGHLNLISVAFAVLFIGLGVDFAIQFSL 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 415 SAWSSIEKHGHSVDSVIKGARKVALPATFGVLTTMAAFY---PTlAISGpwtnaMASMGLVVIFCLMFSLVESKLILPAH 491
Cdd:TIGR03480 346 RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFaflPT-DYKG-----VSELGIIAGTGMFIALFVTLTVLPAL 419
|
170 180 190
....*....|....*....|....*....|....*
gi 2100537107 492 LAHMK-LNKVEDTKNPLLRKVKQFFRGIRLAISGA 525
Cdd:TIGR03480 420 LRLLRpPRRRKPPGYATLAPLDAFLRRHRRPVLGV 454
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
343-610 |
2.13e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 48.70 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 343 IAGVILVFIVLALFLRfKLAFWVMIGIPLCFLGAFALMYMYPAFAmTINMITL-FGFILvLGIVVDDAI-IIAESawssi 420
Cdd:COG4258 256 LISLLGILLLLLLVFR-SLRPLLLGLLPVAVGALAGLAAVSLVFG-SVHGITLgFGSSL-IGVAVDYSLhYLTHR----- 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 421 ekHGHSVDSVIKGARKVALPATFGVLTTMAAFYpTLAISG-PwtnAMASMGLVVIFCLMFSLVESKLILPAhlahmklnk 499
Cdd:COG4258 328 --RAAGEWDPRAALRRIWPTLLLGLLTTVLGYL-ALLFSPfP---GLRQLGVFAAAGLLAAALTTLLWLPL--------- 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 500 vedtknpLLRKVkqfFRGIRLAISGALKRFISnVYAPGLKKLLNyrGLTVLSFICLLLITTVGFiSGGLVKTTMMP---- 575
Cdd:COG4258 393 -------LLPRA---APRPPAPALALLARLLA-RWPRRLRWLLA--LLAVLALASLLGLNRLKW-NDDLRALNPVPaall 458
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2100537107 576 ----------NVPGDGVFVevkMAEGSTAEQTIRSITIVEEKLNE 610
Cdd:COG4258 459 aqearlrallGAPDVSQYL---VVYGPDAEQALQRNEALLPRLDA 500
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
873-1041 |
6.41e-05 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 47.07 E-value: 6.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 873 QVLQDEMALGGLIALLMIYGLMAIPLKSYVKP--AVVMSAIP----FGIIGAMF--GHLLLGLD----LSMFSLFGIIAL 940
Cdd:COG2409 513 DALADDLPLVIPVVLGLIFLLLLLLFRSVVAPlkAVLTNLLSlgaaLGVLVLVFqhGWLLLGFTpgplDSFVPLLLFVIL 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 941 SGVVVNDSLLMVdfiGRAREE---GMSrIDAAVNAGTQRFR------AIILTSLTTFFGLLPITMetslqaqlVIPMAVS 1011
Cdd:COG2409 593 FGLGMDYEVFLV---SRIREEydrGGG-TREAVIRGLARTGrvitsaALIMAAVFAAFATSPLVF--------LKQIGFG 660
|
170 180 190
....*....|....*....|....*....|.
gi 2100537107 1012 LGFGIVF-ATLITLVWVPCLYVLMGntrDWF 1041
Cdd:COG2409 661 LAVGVLLdAFVVRMLLVPALMALLG---RWN 688
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
316-492 |
8.87e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.75 E-value: 8.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 316 PHGISIDAWGDGTYYLKgRLEMMQKNM--IAGVILVFIVLALFLRFKLAFWVMIGIPLCFLG-AFALMYMYpAFAMTINM 392
Cdd:TIGR00921 170 PSGKFLDVTGSPAINYD-IEREFGKDMgtTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGvAWVLGIMG-WLGIPLYA 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 393 ITLFGFILVLGIVVDDAIIIAESAWSSIEKhGHSVDSVIKGARKVALPATFGVLTTMAAFYPTLAISGpwTNAMASMGLV 472
Cdd:TIGR00921 248 TTLLAVPMLIGVGIDYGIQTLNRYEEERDI-GRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSE--FPMVSEFGLG 324
|
170 180
....*....|....*....|
gi 2100537107 473 VIFCLMFSLVESKLILPAHL 492
Cdd:TIGR00921 325 LVAGLITAYLLTLLVLPALL 344
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
336-492 |
2.48e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 45.21 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 336 EMMQKNMIAGVILVFIV-LALFLRFKLAFWVMIGIPLCFLGAFALMYM--YPAFAMTINMITLfgfilVLGIVVDDAIII 412
Cdd:TIGR00921 567 EGMRRMTIAGAILVLMIlLAVFRNPIKAVFPLIAIGSGILWAIGLMGLrgIPSFLAMATTISI-----ILGLGMDYSIHL 641
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 413 AESAWSSIEKHGhSVDSVIKGARKVALPATFGVLTTMAAFYPTLAISGPwtnAMASMGLVVIFCLMFSLVESKLILPAHL 492
Cdd:TIGR00921 642 AERYFEERKEHG-PKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFP---IMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
834-1033 |
2.95e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.83 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 834 QAAITPGEVHmDMMQNVIPDILQEHPS--VKLVPGGPSEDEQVLQDEMALG-GLIALLMIYGLMAIPLKSY--VKPAVVM 908
Cdd:TIGR00921 519 QVQLKQGEPK-VQGRKILRDVQHEHPPpgVKVGVTGLPVAFAEMHELVNEGmRRMTIAGAILVLMILLAVFrnPIKAVFP 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 909 SAIPFGIIGAMFGHL-LLGLDLSMFSLFGIIALSGVVVNDSLLMVDfigRAREE--GMSRIDAAVNAGTQRFRAIILTSL 985
Cdd:TIGR00921 598 LIAIGSGILWAIGLMgLRGIPSFLAMATTISIILGLGMDYSIHLAE---RYFEErkEHGPKEAITHTMERTGPGILFSGL 674
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2100537107 986 TTFFGLLPITMETslqaqlvIPMAVSLGF----GIVFATLITLVWVPCLYVL 1033
Cdd:TIGR00921 675 TTAGGFLSLLLSH-------FPIMRNFGLvqgiGVLSSLTAALVVFPALLVL 719
|
|
| 2A0604s01 |
TIGR00916 |
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ... |
881-1020 |
4.06e-04 |
|
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273336 [Multi-domain] Cd Length: 192 Bit Score: 42.63 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 881 LGGLIALLMIYGLMAIPLKSYVKPAVVmSAIPFGIIgAMFGHL-LLGLDLSMFSLFGIIALSGVVVNDSLLMVDfigRAR 959
Cdd:TIGR00916 51 IALLIGLVLVLLYMLLRYEWRGAIAAI-AALVHDVI-LILGVLsLFGATLTLPGIAGLLTIIGYSVDDTVVIFD---RIR 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2100537107 960 EE-----GMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSlqaQLVIPMAVSLGFGIVFAT 1020
Cdd:TIGR00916 126 EElrkykGRTFREAINLGINQTLSRIIDTNVTTLLAVLALYVFGG---GAIKGFALTLGIGVIAGT 188
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
864-1050 |
4.43e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.44 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 864 VPGGPSEDEQVLqdEMALGGLIALLMIYG-LMAIPL----KSYVKPAVVMSAIPFGII---GAMFghlLLGLDLSMFSLF 935
Cdd:TIGR00921 177 VTGSPAINYDIE--REFGKDMGTTMAISGiLVVLVLlldfKRWWRPLLPLVIILFGVAwvlGIMG---WLGIPLYATTLL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 936 GIIALSGVVVNDSLLMVDFIGRAREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLpiTMETSlqaqlVIPM----AVS 1011
Cdd:TIGR00921 252 AVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFA--ALALS-----EFPMvsefGLG 324
|
170 180 190
....*....|....*....|....*....|....*....
gi 2100537107 1012 LGFGIVFATLITLVWVPCLYVLMgntrDWFlkRDAKSLE 1050
Cdd:TIGR00921 325 LVAGLITAYLLTLLVLPALLQSI----DIG--REKVKKE 357
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
794-1034 |
4.45e-04 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 44.33 E-value: 4.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 794 PDGDYVTFSDVATYKV-SEGYSRISRIDGVRANRISADVSQQA-AITPGEV---HMDMMQNVIPD---ILQEHPSVKLVP 865
Cdd:TIGR00915 255 TDGSQVRLKDVARVELgGENYSISARFNGKPASGLAIKLATGAnALDTAKAvkaELAVLEPFFPQgmkYVYPYDTTPFVE 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 866 GGPSEDEQVLQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAipFGIIGAMfghlllGLDLSMFSLFGIIALSGVVV 945
Cdd:TIGR00915 335 ASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGT--FAVLAAF------GFSINTLTMFAMVLAIGLLV 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 946 NDSLLMVDFIGR-AREEGMSRIDAAVNAGTQRFRAIILTSLTTFFGLLPITMETSLQAQLVIPMAVSLGFGIVFATLITL 1024
Cdd:TIGR00915 407 DDAIVVVENVERvMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVAL 486
|
250
....*....|
gi 2100537107 1025 VWVPCLYVLM 1034
Cdd:TIGR00915 487 ILTPALCATM 496
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
875-1028 |
7.33e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 43.69 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 875 LQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLGLDLSMFSLFGIIALSGVVVNDSLlmvdF 954
Cdd:COG4258 637 YRNDALWLLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL----F 712
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2100537107 955 IGRAREEGMSRidaavnagTQRFRAIILTSLTTF--FGLLpITMETS-LQAqlvipMAVSLGFGIVFATLITLVWVP 1028
Cdd:COG4258 713 FTEGLLDKGEL--------ARTLLSILLAALTTLlgFGLL-AFSSTPaLRS-----FGLTVLLGILLALLLAPLLAP 775
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
859-1035 |
9.88e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 43.22 E-value: 9.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 859 PSVKLVPGGP----SEDEQVLQDEMALGGLIALLMIYGLMAIPLKSYVKPAVVMSAIPFGIIGAMFGHLLLG--LDLSMF 932
Cdd:COG2409 147 PGLTVYVTGPaalaADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAafTDVSSF 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2100537107 933 SLFGIIALS-GVVVNDSLLMVdfiGRAREE---GMSRIDAAVNAGTQRFRAIILTSLTTFFGLL-----PITMETSlqaq 1003
Cdd:COG2409 227 APNLLTMLGlGVGIDYALFLV---SRYREElraGEDREEAVARAVATAGRAVLFSGLTVAIALLglllaGLPFLRS---- 299
|
170 180 190
....*....|....*....|....*....|..
gi 2100537107 1004 lvipMAVSLGFGIVFATLITLVWVPCLYVLMG 1035
Cdd:COG2409 300 ----MGPAAAIGVAVAVLAALTLLPALLALLG 327
|
|
| |
