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Conserved domains on  [gi|2102977156|ref|WP_224039291|]
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tripartite tricarboxylate transporter substrate-binding protein [Cupriavidus sp.]

Protein Classification

type 2 periplasmic-binding domain-containing protein( domain architecture ID 229383)

type 2 periplasmic-binding protein (PBP2) is typically comprised of two globular subdomains connected by a flexible hinge; it binds its ligand in the cleft between these domains in a manner resembling a Venus flytrap; similar to the ligand-binding domains found in solute binding proteins that serve as initial receptors in the transport, signal transduction and channel gating

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Periplasmic_Binding_Protein_Type_2 super family cl21456
Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent ...
 13-212 2.70e-89

Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent the ligand-binding domains found in solute binding proteins that serve as initial receptors in the transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1 (PBP1), but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The origin of PBP module can be traced across the distant phyla, including eukaryotes, archebacteria, and prokaryotes. The majority of PBP2 proteins are involved in the uptake of a variety of soluble substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction. The substrate binding domain of the LysR transcriptional regulators and the oligopeptide-like transport systems also contain the type 2 periplasmic binding fold and thus they are significantly homologous to that of the PBP2; however, these two families are grouped into a separate hierarchy of the PBP2 superfamily due to the large number of protein sequences.


The actual alignment was detected with superfamily member cd13578:

Pssm-ID: 473866  Cd Length: 291  Bit Score: 264.36  E-value: 2.70e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:cd13578    93 SLIASSPLVLVVNPSSPAKTLAELIAAAKANPGKLNYASSGNGSSPHLAGELFKSAAGIDMVHVPYKGSGPALTDLLGGQ 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:cd13578   173 VDLMFDSLPSALPHVKAGKLRALAVTSAKRSPLLPDVPTVAEA-GLPGFEVSSWYGLFAPAGTPAAIVARLNAAVNKALA 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVADS 212
Cdd:cd13578   252 DPDVRARLAAQGVEPVGSTPAEFGAFVAAEIARWAKVVKE 291
 
Name Accession Description Interval E-value
PBP2_Bug27 cd13578
Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the ...
 13-212 2.70e-89

Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold; Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.


Pssm-ID: 270296  Cd Length: 291  Bit Score: 264.36  E-value: 2.70e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:cd13578    93 SLIASSPLVLVVNPSSPAKTLAELIAAAKANPGKLNYASSGNGSSPHLAGELFKSAAGIDMVHVPYKGSGPALTDLLGGQ 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:cd13578   173 VDLMFDSLPSALPHVKAGKLRALAVTSAKRSPLLPDVPTVAEA-GLPGFEVSSWYGLFAPAGTPAAIVARLNAAVNKALA 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVADS 212
Cdd:cd13578   252 DPDVRARLAAQGVEPVGSTPAEFGAFVAAEIARWAKVVKE 291
TctC COG3181
Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC [Energy ...
 13-216 4.14e-87

Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC [Energy production and conversion];


Pssm-ID: 442414  Cd Length: 324  Bit Score: 260.08  E-value: 4.14e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:COG3181   122 ALLATDPLVLVVNPDSPAKTLAELIAAAKANPGKLNYGSSGVGSSDHLAGELFKKAAGIDMTHVPYKGGGPALTDLLGGQ 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:COG3181   202 VDAMFDSLSEALPQIKAGKLRALAVTSPERSPALPDVPTLAEA-GLPGFEASSWRGLFAPAGTPPAVVAKLNAALAKALA 280

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVADSAKVR 216
Cdd:COG3181   281 DPEVRERLAALGLEPVGSTPEEFAAFIAAEIARWGEVIKAAGIK 324
TctC pfam03401
Tripartite tricarboxylate transporter family receptor; These probable extra-cytoplasmic solute ...
 13-209 8.98e-57

Tripartite tricarboxylate transporter family receptor; These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria. This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families. The TctABC system has been characterized in S. typhimurium, and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria.


Pssm-ID: 397461  Cd Length: 274  Bit Score: 181.14  E-value: 8.98e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:pfam03401  73 SLLATYPFVLVVPADSPFKTLTELIAYAKANPGKLSYASPGIGTSNHLAMELLASKAGVQLSHIPYKGSSPAVQDLLAGH 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:pfam03401 153 VDSMIASLPSWLPYIEAGKLRALGVTSEDRSARLPDVPTVAES-GYKGFEVTSWFGLFAPKGTPPAVVQKLHDAFKKAMD 231

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRV 209
Cdd:pfam03401 232 APAVVEALANFGMEPYYGNPQQLADFIQDEVKRWGAL 268
 
Name Accession Description Interval E-value
PBP2_Bug27 cd13578
Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the ...
 13-212 2.70e-89

Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold; Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.


Pssm-ID: 270296  Cd Length: 291  Bit Score: 264.36  E-value: 2.70e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:cd13578    93 SLIASSPLVLVVNPSSPAKTLAELIAAAKANPGKLNYASSGNGSSPHLAGELFKSAAGIDMVHVPYKGSGPALTDLLGGQ 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:cd13578   173 VDLMFDSLPSALPHVKAGKLRALAVTSAKRSPLLPDVPTVAEA-GLPGFEVSSWYGLFAPAGTPAAIVARLNAAVNKALA 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVADS 212
Cdd:cd13578   252 DPDVRARLAAQGVEPVGSTPAEFGAFVAAEIARWAKVVKE 291
TctC COG3181
Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC [Energy ...
 13-216 4.14e-87

Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC [Energy production and conversion];


Pssm-ID: 442414  Cd Length: 324  Bit Score: 260.08  E-value: 4.14e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:COG3181   122 ALLATDPLVLVVNPDSPAKTLAELIAAAKANPGKLNYGSSGVGSSDHLAGELFKKAAGIDMTHVPYKGGGPALTDLLGGQ 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:COG3181   202 VDAMFDSLSEALPQIKAGKLRALAVTSPERSPALPDVPTLAEA-GLPGFEASSWRGLFAPAGTPPAVVAKLNAALAKALA 280

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVADSAKVR 216
Cdd:COG3181   281 DPEVRERLAALGLEPVGSTPEEFAAFIAAEIARWGEVIKAAGIK 324
PBP2_Bug_TTT cd07012
Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains ...
 13-212 6.67e-85

Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold; The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.


Pssm-ID: 270234  Cd Length: 291  Bit Score: 253.16  E-value: 6.67e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:cd07012    93 ALLATDPLVLVVNADSPYKTLAELVAAAKANPGKLTYGSAGAGSSSHLAGELLAQAAGIKLTHVPYKGGAPALTDLLGGQ 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:cd07012   173 VDAAFDSLSEALPQIKAGKLRALAVTSPERLPLLPDVPTLAEQ-GLPDFEVSSWRGLFAPAGTPPEVVAKLNAALAKALA 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVADS 212
Cdd:cd07012   252 DPEVRERLAALGLEPVYLTPAEFAAFLRAETARWGKLIKA 291
PBP2_BugD_Asp cd13576
Aspartic acid transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 ...
 14-210 2.07e-63

Aspartic acid transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold; The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.


Pssm-ID: 270294  Cd Length: 294  Bit Score: 198.75  E-value: 2.07e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  14 LVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQI 93
Cdd:cd13576    94 LIADTPMILVARKDFPAKDLKELVAWVKANPAKVTLGNAGVGSASHLCGVLLQSALGIKATLVPYKGTGPAMNDLIGGQV 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  94 NVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQD 173
Cdd:cd13576   174 DLMCDQTTNALPQIQAGKVRAYAVTSTERLASLPDVPTSAEA-GLPGFEATIWNGLFAPKGTPPAVIAKLNAALKTALND 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2102977156 174 PEVRDKLMAQGAQIAGG---TPEAFNALLRAEVSKWKRVA 210
Cdd:cd13576   253 PAVRKRFADLGLEPPPPeqlTPEALQQLVKAEVERWAPVI 292
PBP2_BugE_Glu cd13577
Glutamate transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 ...
 13-212 6.62e-60

Glutamate transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold; The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.


Pssm-ID: 270295  Cd Length: 292  Bit Score: 189.48  E-value: 6.62e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:cd13577    94 ANVVTVPNVLVVHPSVPAKDFKAFVAYLKANPGKYSYASPGAGTLGHLTAELFKQALGTKIVHVPYRGSGPALTDLLAGQ 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEaLGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:cd13577   174 VQVMFDNLPSSLPHIKSGKLRALAVAWPTRLAALPDVPTFAE-LGFPDLNQPSWYGLVAPAGTPADVVAKLHDAAVKALA 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVADS 212
Cdd:cd13577   253 DPAVRKRLEELGLVPPGNTPAQFAAQIQAQFAKWKPVADK 292
TctC pfam03401
Tripartite tricarboxylate transporter family receptor; These probable extra-cytoplasmic solute ...
 13-209 8.98e-57

Tripartite tricarboxylate transporter family receptor; These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria. This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families. The TctABC system has been characterized in S. typhimurium, and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria.


Pssm-ID: 397461  Cd Length: 274  Bit Score: 181.14  E-value: 8.98e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  13 SLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPSLTDVLGQQ 92
Cdd:pfam03401  73 SLLATYPFVLVVPADSPFKTLTELIAYAKANPGKLSYASPGIGTSNHLAMELLASKAGVQLSHIPYKGSSPAVQDLLAGH 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  93 INVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEAlGISGYEAVSWGGFMVPSGTSQAIIAKMNSEFNKALQ 172
Cdd:pfam03401 153 VDSMIASLPSWLPYIEAGKLRALGVTSEDRSARLPDVPTVAES-GYKGFEVTSWFGLFAPKGTPPAVVQKLHDAFKKAMD 231

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2102977156 173 DPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRV 209
Cdd:pfam03401 232 APAVVEALANFGMEPYYGNPQQLADFIQDEVKRWGAL 268
PBP2_Bug_NagM cd13579
Uncharacterized NagM-like protein of Bug (Bordetella uptake gene) protein family; contains the ...
 5-210 8.44e-55

Uncharacterized NagM-like protein of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold; The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.


Pssm-ID: 270297  Cd Length: 292  Bit Score: 176.70  E-value: 8.44e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156   5 AQTSLISNSLVTTVPLIIVTAANSPIKDLRQLVSMAKARPGQITFGCAGNGSGSHLAGELLSTMAGVKMNHVPYKGDAPS 84
Cdd:cd13579    86 PATDFTPVALVATFPLALAVGPASPVKTLKDFVAWAKAHPGQASVGVPAPGSLPHFLGLLLGKALGVDLTHVPYRGSAPM 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102977156  85 LTDVLGQQINVALPTSLAGMPQVKSGKLRALAVTSKTRLPSLPDVPTVDEaLGISGYEAVSWGGFMVPSGTSQAIIAKMN 164
Cdd:cd13579   166 VQDLLGGQIAAGVDTLGDLLPHHRAGKLRILAVSGAQRSAALPDVPTFAE-LGFKGLEASGWYGFFAPAGTPAAVVDRLS 244

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2102977156 165 SEFNKALQDPEVRDKLMAQGAQIAGGTPEAFNALLRAEVSKWKRVA 210
Cdd:cd13579   245 AAIRAALASPDVREKLAELGLEPAGGSPAELARRLKAERARWGPVV 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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