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Conserved domains on  [gi|2103680396|ref|WP_224222065|]
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4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [Streptomyces olivaceus]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11479886)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 3-286 9.77e-123

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


:

Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 353.04  E-value: 9.77e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   3 VTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATPdADGLRVTCEGPDAGQVPLDRTNLAARAALALAERYG 82
Cdd:PRK03188    1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTA-ADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  83 RAPDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGERLTELQV 162
Cdd:PRK03188   80 RAPDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 163 GGDFHWVFALAARGLSTPAVFREFDRLGEGLDIPEPAADQAVLDALAKGDPAALAVAVTNDLQPAALSLFPELSDTLAAG 242
Cdd:PRK03188  160 RGTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2103680396 243 RAAGALAALVSGSGPTTAFLAPDARSASDIAGVLRASGTCRDVR 286
Cdd:PRK03188  240 EEAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVR 283
 
Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 3-286 9.77e-123

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 353.04  E-value: 9.77e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   3 VTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATPdADGLRVTCEGPDAGQVPLDRTNLAARAALALAERYG 82
Cdd:PRK03188    1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTA-ADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  83 RAPDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGERLTELQV 162
Cdd:PRK03188   80 RAPDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 163 GGDFHWVFALAARGLSTPAVFREFDRLGEGLDIPEPAADQAVLDALAKGDPAALAVAVTNDLQPAALSLFPELSDTLAAG 242
Cdd:PRK03188  160 RGTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2103680396 243 RAAGALAALVSGSGPTTAFLAPDARSASDIAGVLRASGTCRDVR 286
Cdd:PRK03188  240 EEAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVR 283
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-283 5.22e-71

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 220.76  E-value: 5.22e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   2 SVTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATP-DADGLRVTCEGPDagqVPLDRTNLAARAALALAER 80
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPaDDGSISLTGPGAG---VPTDEDNLVYRAARLLQEA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  81 YGRAPDVHLHIAKDIPVAGGmaggsadgagaLLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGERLTEL 160
Cdd:COG1947    78 TGIPPGVDIHLEKRIPVGAGlgggssdaaatLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 161 QVGGDFHWVFALAARGLSTPAVFREFDRlgegLDIPEPAADQAVLDALAKGDpAALAVAVTNDLQPAALSLFPELSDTLA 240
Cdd:COG1947   158 PPLPELWLVLVKPGVGVSTAEVYRALDL----TRDTPPPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLE 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2103680396 241 AGRAAGALAALVSGSGPTTAFLAPDARSASDIAGVLRASGTCR 283
Cdd:COG1947   233 ALLEAGALAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVF 275
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-258 9.25e-30

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 114.15  E-value: 9.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   1 MSVTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATPDADGL-RVTCEGPDagqVPLDRtNLAARAALALAE 79
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDiRLLKGDFD---VPLEE-NLAYRAAQLLKN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  80 RYGRAPD----VHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGE 155
Cdd:TIGR00154  77 FANSKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 156 RLTELQVGGDFHWVFALAARGLSTPAVFREFDrlgegLDIPEPAADQAVLDALAKGDPAALAVAVTNDLQPAALSLFPEL 235
Cdd:TIGR00154 157 IITPFEDPPEKWVVIAKPHVSVSTPVVYQAYK-----LPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEV 231

                         250       260
                  ....*....|....*....|...
gi 2103680396 236 SDTLAAGRAAGALAALVSGSGPT 258
Cdd:TIGR00154 232 AQALNWLLEYGLAPERMSGSGPC 254
 
Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 3-286 9.77e-123

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 353.04  E-value: 9.77e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   3 VTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATPdADGLRVTCEGPDAGQVPLDRTNLAARAALALAERYG 82
Cdd:PRK03188    1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTA-ADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  83 RAPDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGERLTELQV 162
Cdd:PRK03188   80 RAPDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 163 GGDFHWVFALAARGLSTPAVFREFDRLGEGLDIPEPAADQAVLDALAKGDPAALAVAVTNDLQPAALSLFPELSDTLAAG 242
Cdd:PRK03188  160 RGTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2103680396 243 RAAGALAALVSGSGPTTAFLAPDARSASDIAGVLRASGTCRDVR 286
Cdd:PRK03188  240 EEAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVR 283
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-283 5.22e-71

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 220.76  E-value: 5.22e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   2 SVTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATP-DADGLRVTCEGPDagqVPLDRTNLAARAALALAER 80
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPaDDGSISLTGPGAG---VPTDEDNLVYRAARLLQEA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  81 YGRAPDVHLHIAKDIPVAGGmaggsadgagaLLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGERLTEL 160
Cdd:COG1947    78 TGIPPGVDIHLEKRIPVGAGlgggssdaaatLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 161 QVGGDFHWVFALAARGLSTPAVFREFDRlgegLDIPEPAADQAVLDALAKGDpAALAVAVTNDLQPAALSLFPELSDTLA 240
Cdd:COG1947   158 PPLPELWLVLVKPGVGVSTAEVYRALDL----TRDTPPPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLE 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2103680396 241 AGRAAGALAALVSGSGPTTAFLAPDARSASDIAGVLRASGTCR 283
Cdd:COG1947   233 ALLEAGALAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVF 275
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-258 9.25e-30

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 114.15  E-value: 9.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   1 MSVTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATPDADGL-RVTCEGPDagqVPLDRtNLAARAALALAE 79
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDiRLLKGDFD---VPLEE-NLAYRAAQLLKN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  80 RYGRAPD----VHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGE 155
Cdd:TIGR00154  77 FANSKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 156 RLTELQVGGDFHWVFALAARGLSTPAVFREFDrlgegLDIPEPAADQAVLDALAKGDPAALAVAVTNDLQPAALSLFPEL 235
Cdd:TIGR00154 157 IITPFEDPPEKWVVIAKPHVSVSTPVVYQAYK-----LPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEV 231

                         250       260
                  ....*....|....*....|...
gi 2103680396 236 SDTLAAGRAAGALAALVSGSGPT 258
Cdd:TIGR00154 232 AQALNWLLEYGLAPERMSGSGPC 254
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-278 3.40e-25

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 101.85  E-value: 3.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   1 MSVTVRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATP-DADGLRVTceGPDAGQVPLDRTNLAARAALALAE 79
Cdd:PRK14608    5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPaEALSLTVS--GPFAAGLGDGDDNLVLRAARALRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  80 RYGR-APDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGERLT 158
Cdd:PRK14608   83 RVGPgLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 159 ELQVGGDFHWVFALAARGLSTPAVFREFD-RLGEGLDIPEPAADQAvlDALAkgdpAALAvAVTNDLQPAALSLFPELSD 237
Cdd:PRK14608  163 PLPGLPSLPAVLVNPGVPVATPDVFRALGlRDGPPLPGAPDPLASA--DALL----AALA-ATRNDLEPPALALAPVIGE 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2103680396 238 TLAAGRAAGALAAL-VSGSGPTTAFLAPDARSASDIAGVLRA 278
Cdd:PRK14608  236 VLAALRAQPGALLArMSGSGATCFALFADEAAAEAAAAAIAA 277
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
5-235 2.50e-19

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 85.58  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   5 VRVPAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATPdADGLRVTCEGPDAGQvpldRTNLAARAALALAERYGRA 84
Cdd:PRK14611    4 LLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKE-HHTLEVKTSSPQIKE----EENIVYKALRLFERYTGID 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  85 PDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALGTGRGERLTELQVGG 164
Cdd:PRK14611   79 INYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLEKPI 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2103680396 165 DFHWVFALAARGLSTPAVFREFDRlgEGLDIPEpaADQAVLDALAKGDPAALAVAVTNDLQPAALSLFPEL 235
Cdd:PRK14611  159 SREITLVYPNIKSSTGRVYSKVTK--QILTNKE--DLNIIISLLREGEEKKIEEVIENTLGEIALELYPEI 225
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
8-256 3.31e-16

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 77.25  E-value: 3.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   8 PAKVNVQLAVGAARADGFHDLANVFLAVSLYDEVTATPDADGLRV-----------------TCEGPDAGQVPLDRTnla 70
Cdd:PRK14613    4 PAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFElfstneiilekrklydqVSERGDIKQNILYKT--- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  71 araALALAERYGRAPDVHLHIAKDIPvAGGMAGGSADGAGALLACDALWGTGASRDELLALCAELGSDVPFSLVGGAALG 150
Cdd:PRK14613   81 ---FIKARSLFPELPGVKIHLTKRIS-PAGGLGGGSTNAASLLNFLFSWRNFFTSDEMQVFAKEIGSDVPFFLGEGHAFV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 151 TGRGERLTELQVGGDFHwVFALAARGLSTPAVFREFDRlgeglDIPEPAAD-------QAVLDALAKGDPAALAVAVTND 223
Cdd:PRK14613  157 TGKGEIMEEIEVHKGQG-ILALTPQVMNTGEMYALLKK-----PLQESASQkngntlsEDLISSLKVGDWVSLQGRLEND 230

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2103680396 224 LQPAALSLFPELSDTLAAGRAAGALAALVSGSG 256
Cdd:PRK14613  231 FEPVAFQLHPELGVLKDKFLEFGSSYCSLTGSG 263
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 1-278 2.16e-11

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 63.19  E-value: 2.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   1 MSVTVRVPAKVnvqlavgaaradgfhdlANV---F----LAVSLYDEVTATP-DADGLRVTCEGPDAGQVPLDRTNLAAR 72
Cdd:COG0083     1 KSVKVRVPATS-----------------ANLgpgFdslgLALSLYDEVEVERsDEPGLEIEIEGEGADELPTDEDNLVYQ 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  73 AALALAERYGRA-PDVHLHIAKDIP------------VAGgmaggsadgagaLLACDALWGTGASRDELLALCAELGS-- 137
Cdd:COG0083    64 AALALLEKLGKEpPGLRIEIEKGIPlgrglgssaaaiVAG------------LVAANALLGLPLSKEELLELATEGEGhp 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 138 D--VPfSLVGGAALGTGRGERL--TELQVGGDFHWVFALAARGLST-------PAVFREFD------RLGegldipepaa 200
Cdd:COG0083   132 DnvAP-ALLGGLVLSRSDGEPVrvVRLPVPPDLKAVVVIPDFELSTkearavlPKQVPLKDavfnssRAA---------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 201 dqAVLDALAKGDPAALAVAvTNDL--QPAALSLFPELSDTLAAGRAAGALAALVSGSGPTTAFLAPDaRSASDIAGVLRA 278
Cdd:COG0083   201 --LLVAALATGDYELLGRA-MEDRlhEPYRAKLIPGFDEVKEAALEAGALGAGISGAGPTVLALADD-EEAEAVAEAMKA 276
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 33-269 1.13e-08

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 55.10  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  33 LAVSLYDEVTATPD----ADGLRVTCEGPDAGQVPLDRT-NLAARAALALAERYG-RAPDVHLHIAKDIPVAGGMAGGSA 106
Cdd:TIGR00191  21 AALSLYLGLTVTDVvaqeSDDTEIEAEGEGVEKIPTEPTdNLIYQVAKRFLDQLGiRMPPVKVTLEKNIPLGRGLGSSAA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 107 DGAGALLACDALWGTGASRDELLALCAEL---GSDVPFSLVGGAALGTGRGERLTELQV--GGDFHWVFALAARGLSTpa 181
Cdd:TIGR00191 101 AIVAALAAANELCGLPLSKERLLDYASELeghPDNVAPALLGGFQLAFVEDDKLEVLKIpiFSKLDWVLAIPNIEVST-- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 182 vfrefdrlgegldipepAADQAVL-------DALAKGDPAALAV-AVTND-------------LQPAALSLFPELSDTLA 240
Cdd:TIGR00191 179 -----------------AEARAVLpkayprqDLVFNLSHLAGLVhAIYQKkpdlgaimmkdriHQPYRESLIPNLFKIKQ 241

                         250       260
                  ....*....|....*....|....*....
gi 2103680396 241 AGRAAGALAALVSGSGPTTAFLAPDARSA 269
Cdd:TIGR00191 242 AALEKGAYGITISGSGPTILAMADEEFAE 270
PRK01212 PRK01212
homoserine kinase; Provisional
 1-258 9.99e-06

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 46.29  E-value: 9.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396   1 MSVTVRVPAKVnvqlavgaaradgfhdlANV---F----LAVSLYDEVTATPDADGLR---VTCEGPDAGQVPLD-RTNL 69
Cdd:PRK01212    2 MMVKVRVPATS-----------------ANLgpgFdslgLALSLYDEVLVGDVVSVEAefsIEVIGEGADKLPLDpEKNL 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396  70 AARAALALAERYGRAPDVHLHIAKDIP------------VaggmaggsadgaGALLACDALWGTGASRDELLALCAELGS 137
Cdd:PRK01212   65 VYQAALKFLEKLGKPPGLRIELEKNIPlgrglgssaasiV------------AGLVAANELAGLPLSKEELLQLATEGEG 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 138 --D--VPfSLVGGAALG-TGRGERLTELQVGGDFHWVFALAARGLST-------PAVFrefdRLGEgldipepAADQ--- 202
Cdd:PRK01212  133 hpDnvAP-ALLGGLVLAlEENGVISVKIPVFDDLKWVVAIPNIELSTaearavlPKQY----SLKD-------AVFNssr 200

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 203 --AVLDALAKGDPaALAVAVTNDL--QPAALSLFPELSDTLAAGRAAGALAALVSGSGPT 258
Cdd:PRK01212  201 aaLLVAALYTGDY-ELAGRAMKDVlhEPYRAKLIPGFAEVRQAALEAGALGAGISGAGPT 259
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 112-237 7.71e-05

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 43.41  E-value: 7.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103680396 112 LLACDALWGTGASRDELLALCAELGSDVPFSLVG-GAALGTGRGE-------RLTELQVggDFHWVFAlaarglSTPAVF 183
Cdd:PRK04181  112 LLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEiveefeeEILNLEI--FTPNIFC------STKAVY 183

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2103680396 184 REFDRLGEGLDIPEPAA---DQAVLDALAKGDPAALavavtNDLQPAALSLFPELSD 237
Cdd:PRK04181  184 KAYREEFYDFISFNQAKellKLSSLELLKNFKNTEL-----NDLLAPALKLYPALKD 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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