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Conserved domains on  [gi|2104000359|ref|WP_224433327|]
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MULTISPECIES: methionine ABC transporter permease [Corynebacterium]

Protein Classification

methionine ABC transporter permease( domain architecture ID 10005172)

methionine ABC transporter permease is the transmembrane (TM) subunit of the ABC transporter complex, such as MetNPQ, that is involved in methionine import, and is responsible for the translocation of the substrate across the membrane

EC:  7.4.2.11
Gene Ontology:  GO:0033232|GO:0048473|GO:0042626
PubMed:  22095702|11421270|25750732|24638992
TCDB:  3.A.1.24

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 1-210 1.97e-92

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 441614  Cd Length: 220  Bit Score: 269.62  E-value: 1.97e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   1 MLGEAFGQTLYMVCVAMLIGGVAGLAIGVLLYTTRDGGVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVGTTI 80
Cdd:COG2011    11 LLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRPGGLLPNPVLYRVLGVIVNIFRSIPFIILLVALIPLTRLIVGTSI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  81 GTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMAGYI 160
Cdd:COG2011    91 GTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISLIGYSAMAGAV 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2104000359 161 GGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKIMRR 210
Cdd:COG2011   171 GGGGLGDLAIRYGYQRFDTDVMLVTVVILIVLVQIIQFLGDRLARRLDHR 220
 
Name Accession Description Interval E-value
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 1-210 1.97e-92

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 269.62  E-value: 1.97e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   1 MLGEAFGQTLYMVCVAMLIGGVAGLAIGVLLYTTRDGGVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVGTTI 80
Cdd:COG2011    11 LLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRPGGLLPNPVLYRVLGVIVNIFRSIPFIILLVALIPLTRLIVGTSI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  81 GTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMAGYI 160
Cdd:COG2011    91 GTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISLIGYSAMAGAV 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2104000359 161 GGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKIMRR 210
Cdd:COG2011   171 GGGGLGDLAIRYGYQRFDTDVMLVTVVILIVLVQIIQFLGDRLARRLDHR 220
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
8-210 1.76e-40

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 137.17  E-value: 1.76e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   8 QTLYMVCVAMLIGGVAGLAIGVLLYTTRDGGVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVGTTIGTEAAVF 87
Cdd:PRK10782   15 ETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIIANAKLYRTLSALVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  88 VMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMAGYIGGGGLGN 167
Cdd:PRK10782   95 PLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQ 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2104000359 168 FAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKIMRR 210
Cdd:PRK10782  175 IGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGDRIVRAVTHK 217
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 5-207 5.91e-11

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 59.86  E-value: 5.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   5 AFGQTLYMVCVAMLIGGVAGLAIGVLlyttRDGGVLRNKFVYQVLNVLINFVRPIP----FIILVTAIGPltknvvgtti 80
Cdd:TIGR01097  59 ALLETLAMAILGTVLAAVLAVPLALL----AARNITPSPWLYGLARLLLNFLRAIPelvwALIFVAAVGL---------- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  81 GTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALgPLVLGYTFAFIAVVDMSAMAGYI 160
Cdd:TIGR01097 125 GPFAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVL-PQFLSYTLYRFEINVRAAAVLGL 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2104000359 161 GGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKI 207
Cdd:TIGR01097 204 VGAGGIGLELDTAIGLFDYDEVSAIILVILVVVVIIDLISARLRRRL 250
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 38-210 9.28e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 53.07  E-value: 9.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  38 GVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVgTTIGTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAAR 117
Cdd:pfam00528   9 ALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSI-LGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAAR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359 118 AMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMAGYIGGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQ 197
Cdd:pfam00528  88 ALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLN 167

                         170
                  ....*....|...
gi 2104000359 198 IFGNWLSKKIMRR 210
Cdd:pfam00528 168 LLVDILQRLLDPR 180
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 6-193 2.61e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 51.90  E-value: 2.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   6 FGQTLYMVCVAMLIGGVAGLAIGVLLyttrdggVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVGTTIG---T 82
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIIL-------ARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  83 EAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMA----- 157
Cdd:cd06261    74 LPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVsflgg 153

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2104000359 158 GYIGGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIV 193
Cdd:cd06261   154 GEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
 
Name Accession Description Interval E-value
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 1-210 1.97e-92

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 269.62  E-value: 1.97e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   1 MLGEAFGQTLYMVCVAMLIGGVAGLAIGVLLYTTRDGGVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVGTTI 80
Cdd:COG2011    11 LLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRPGGLLPNPVLYRVLGVIVNIFRSIPFIILLVALIPLTRLIVGTSI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  81 GTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMAGYI 160
Cdd:COG2011    91 GTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISLIGYSAMAGAV 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2104000359 161 GGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKIMRR 210
Cdd:COG2011   171 GGGGLGDLAIRYGYQRFDTDVMLVTVVILIVLVQIIQFLGDRLARRLDHR 220
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
8-210 1.76e-40

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 137.17  E-value: 1.76e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   8 QTLYMVCVAMLIGGVAGLAIGVLLYTTRDGGVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVGTTIGTEAAVF 87
Cdd:PRK10782   15 ETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIIANAKLYRTLSALVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  88 VMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMAGYIGGGGLGN 167
Cdd:PRK10782   95 PLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQ 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2104000359 168 FAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKIMRR 210
Cdd:PRK10782  175 IGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGDRIVRAVTHK 217
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 2-210 3.39e-16

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 74.41  E-value: 3.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   2 LGEAFGQTLYMVCVAMLIGGVAGLAIGVLLYttrdggvlRNKFVYQVLNVLINFVRPIPFIilvtAIGPLTKNVVGttIG 81
Cdd:COG0600    59 LWEHLLASLLRVLLGFALAALLGVPLGLLLG--------LSRLLRRLLDPLLVFLRPIPPL----ALAPLLILWFG--IG 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  82 TEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLV----LGYTFAFIAVVdmsaMA 157
Cdd:COG0600   125 EASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFtglrIALGLAWIGLV----VA 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2104000359 158 GYIGGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKIMRR 210
Cdd:COG0600   201 ELLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGLLLDLLLRLLERRLLRW 253
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 2-145 7.95e-13

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 65.10  E-value: 7.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   2 LGEAFGQTLYMVCVAMLIGGVAGLAIGVLlyTTRdgGVLRNKFVYQVLNVLINFVRPIP----FIILVTAIGPltknvvg 77
Cdd:COG3639    49 LLSALLETLAIALLGTLLGAVLALPLAFL--AAR--NLAPNPWVRLLARRLLNVLRAIPelvwALIFVAAVGL------- 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2104000359  78 ttiGTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALgPLVLGYTF 145
Cdd:COG3639   118 ---GPFAGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVL-PQFLSYTL 181
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 2-142 4.83e-11

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 59.68  E-value: 4.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   2 LGEAFGQTLYMVCVAMLIGGVAGLAIGVLLYttrdggvlRNKFVYQVLNVLINFVRPIP----FIILVTAIGpltknvvg 77
Cdd:COG1174    16 ILALLLEHLLLVLLALLIALLIAVPLGILIT--------RRRRLAGLVLGVANILQTIPslalLALLIPLLG-------- 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2104000359  78 ttIGTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALgPLVLG 142
Cdd:COG1174    80 --IGPAPAIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLAL-PVILA 141
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 5-207 5.91e-11

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 59.86  E-value: 5.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   5 AFGQTLYMVCVAMLIGGVAGLAIGVLlyttRDGGVLRNKFVYQVLNVLINFVRPIP----FIILVTAIGPltknvvgtti 80
Cdd:TIGR01097  59 ALLETLAMAILGTVLAAVLAVPLALL----AARNITPSPWLYGLARLLLNFLRAIPelvwALIFVAAVGL---------- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  81 GTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALgPLVLGYTFAFIAVVDMSAMAGYI 160
Cdd:TIGR01097 125 GPFAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVL-PQFLSYTLYRFEINVRAAAVLGL 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2104000359 161 GGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQIFGNWLSKKI 207
Cdd:TIGR01097 204 VGAGGIGLELDTAIGLFDYDEVSAIILVILVVVVIIDLISARLRRRL 250
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 9-151 3.87e-10

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 3.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   9 TLYMVCVAMLIGGVAGLAIGVLlyttrdGGVLRnKFVYQVLNVLINFVRPIPFIILVTAIGPltknVVGTTIGTeaAVFV 88
Cdd:COG1173    81 SLLVGLLAVLIALVIGVLLGLL------AGYFG-GWVDAVLMRLVDVLLAFPSLLLAIALVA----VLGPGLLN--VILA 147

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2104000359  89 MSIAATFAIARLVEQNLMSI-DPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVV 151
Cdd:COG1173   148 LGLTGWPGYARLVRAQVLSLrEREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAI 211
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 38-210 9.28e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 53.07  E-value: 9.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  38 GVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVgTTIGTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAAR 117
Cdd:pfam00528   9 ALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSI-LGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAAR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359 118 AMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMAGYIGGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIVQLAQ 197
Cdd:pfam00528  88 ALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLN 167

                         170
                  ....*....|...
gi 2104000359 198 IFGNWLSKKIMRR 210
Cdd:pfam00528 168 LLVDILQRLLDPR 180
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-136 1.28e-08

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 52.77  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   1 MLGEAFGQTLYMVCVAMLIGGVAGLAIGVLLyttrdggVLRNKFVYQVLNVLINFVRPIPFIILVTAIG---PLtknvVG 77
Cdd:COG0765    14 LLLEGLLVTLLLTVLAIVLGLVLGLLLALAR-------LSPNPVLRWLATAYVEFFRGTPLLVQLFFIYfglPL----LG 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  78 TTIG-TEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEAL 136
Cdd:COG0765    83 IDLSpFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQAL 142
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 6-193 2.61e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 51.90  E-value: 2.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   6 FGQTLYMVCVAMLIGGVAGLAIGVLLyttrdggVLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVGTTIG---T 82
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIIL-------ARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  83 EAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSAMA----- 157
Cdd:cd06261    74 LPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVsflgg 153

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2104000359 158 GYIGGGGLGNFAITYGYQAFDWNVTLVTTLVIIFIV 193
Cdd:cd06261   154 GEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
2-151 1.16e-06

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 48.23  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   2 LGEAFGQTLYMVCVAMLIGGVAGLAIGVLLyttrdggVLRNKFVYQVLNVLINFVRPIPFIILVTA-IGPLTKNVVGTTI 80
Cdd:COG1178   336 LLRALLNSLLLALLAALLAVLLALLLAYLV-------RRRRGRLARLLDRLAMLPYAVPGIVLGLGlLLLFNRPLPLLLY 408

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2104000359  81 GTEAAVFVMSIAATFAIA-RLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVV 151
Cdd:COG1178   409 GTLAILVLAYVVRFLPFAlRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSM 480
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 74-147 5.63e-06

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 45.51  E-value: 5.63e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2104000359  74 NVVGTTIGTEAAVFVmsIAATFAIaRLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAF 147
Cdd:COG0555   131 KVAFTPLGIVLAQTF--VSLPFVV-RTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALAF 201
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
2-151 6.85e-06

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 45.92  E-value: 6.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   2 LGEAFGQTLYMVCVAMLIGGVAGLAIGVLLYTTRdggvLRNKFVYQVLnVLINFVrpIPFIILVTAI-------GPLTK- 73
Cdd:COG1178    52 LWRALGNTLLLALLVTLLSLLLGVPLAWLLARTD----FPGRRLLRWL-LLLPLA--LPPYVVALAWialfgpnGLLNTl 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  74 --NVVGTTI----GTEAAVFVMSIAATFAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAF 147
Cdd:COG1178   125 lrALFGLEPpdiyGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVF 204


                  ....
gi 2104000359 148 IAVV 151
Cdd:COG1178   205 LLCL 208
ssuC PRK11365
aliphatic sulfonate ABC transporter permease SsuC;
15-209 1.29e-05

aliphatic sulfonate ABC transporter permease SsuC;


Pssm-ID: 183100  Cd Length: 263  Bit Score: 44.54  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  15 VAMLIGGVAGLAIGVLLYTTRDGGVLrnkfvyqvLNVLINFVRPIPFIILVtaigPLTknVVGTTIGTEAAVFVMSIAAT 94
Cdd:PRK11365   71 IGFSIGGSLGLILGLISGLSRWGERL--------LDTSIQMLRNVPHLALI----PLV--ILWFGIDESAKIFLVALGTL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  95 FAIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAfiavvdMSAMAGYIGGGGLGNFAITYGY 174
Cdd:PRK11365  137 FPIYINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALPSIMVGVRFA------LGLMWLTLIVAETISANSGIGY 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2104000359 175 QAFDWNVTLVTTLVIIFIV------QLAQIFGNWLSKKIMR 209
Cdd:PRK11365  211 LAMNAREFLQTDVVVVAIIlyallgKLADVSAQLLERLWLR 251
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 104-148 2.25e-05

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 43.98  E-value: 2.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2104000359 104 NLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFI 148
Cdd:COG1176   176 ALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFI 220
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 108-142 7.10e-05

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 42.68  E-value: 7.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2104000359 108 IDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLG 142
Cdd:PRK15050  187 LDARQLEAAASLGASPWRVARRVILPEAWPALAAG 221
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 2-148 1.45e-04

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 41.64  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   2 LGEAFGQTLYMVCVAMLIGGVAGLAIGVLLYTTRdggvLRNKFVYQVLNVLINFVRPI----PFIILVTAIGpLTKNVVG 77
Cdd:COG1177    59 LLDALLNSLLIALLSTLLATVLGTPAALALARYR----FRGRRLLLALLLLPLVVPGIvlgvALLLLFSALG-LSGGLWG 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2104000359  78 TTIGTeaAVFVMSIAATFAIARLveqnlMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFI 148
Cdd:COG1177   134 LILAH--VVFTLPFVVLVVLARL-----QGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFT 197
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 18-136 8.54e-04

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 38.88  E-value: 8.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  18 LIGGVAGLAIGVLLYTTRDGGvlrNKFVYQVLNVLINFVRPIPFIILVTAIG-PLTKNVVGTTI-GTEAAVFVMSIAATF 95
Cdd:PRK09494   27 VLGLAGGLVIGLLAGFARAYG---GWIANHIALVFIELIRGTPIVVQVMFIYfALPMAFNDLRIdPFTAAVVTIMINSGA 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2104000359  96 AIARLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEAL 136
Cdd:PRK09494  104 YIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLAL 144
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-148 1.57e-03

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 38.51  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359   1 MLGEAFGQTLYMVCVAMLIGGVAGLAIGVLlyttrdGGVLRNKFVYQVLNVLINFVRPIP------FIILVTAIG----P 70
Cdd:COG0601    90 LIAERLPVTLELALLALLLALLIGIPLGIL------AALRRGSWLDRLITVLALLGISIPsfwlglLLILLFAVKlgwlP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  71 LTKNVVGTTIGTEAA------VFVMSIAATFAIARLVEQNLMS-IDPGVIEAARAMGASPWRIIRTVVVPEALGPLV--L 141
Cdd:COG0601   164 VSGRVSPWEDFLDALrhlilpALTLALGSLAGIARLTRSSMLEvLGQDYVRTARAKGLSERRVLLRHALRNALIPVVtvL 243


                  ....*..
gi 2104000359 142 GYTFAFI 148
Cdd:COG0601   244 GLQLGGL 250
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 105-147 1.83e-03

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 38.04  E-value: 1.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2104000359 105 LMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAF 147
Cdd:PRK09500  150 LKGFDVRMLEAAKDLGASEFTILRKIILPLALPAVAAGWLLSF 192
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
10-155 3.28e-03

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 37.49  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  10 LYMVCVAMLIGGVAGLAIGVLlyttrdGGVLrNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVgttigteAAVFVM 89
Cdd:PRK09881  101 LVVVAIAGMIGSLLGCLSGVL------GGRA-DAIIMRIMDIMLSIPSLVLTMALAAALGPSLFNAM-------LAIAIV 166

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2104000359  90 SIAATFAIARlvEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAFIAVVDMSA 155
Cdd:PRK09881  167 RIPFYVRLAR--GQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDIGSAILMAA 230
modB PRK09421
molybdate ABC transporter permease subunit;
99-147 5.73e-03

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 36.44  E-value: 5.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2104000359  99 RLVEQNLMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYTFAF 147
Cdd:PRK09421  109 RAIRLSLEAVDRKLEQAARTLGASPWRVFFTITLPLTLPGIIAGTVLAF 157
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 15-144 5.78e-03

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 37.02  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104000359  15 VAMLIGGVAGLAIGvLLYTTRDGgvLRNKFVYQVLNVLINFVRPIPFIILVTAIGPLTKNVVgttigteAAVFVMSIAAt 94
Cdd:PRK15082  108 FSVAIGAAIGTVLG-LLAGYYEG--WWDRIIMRICDVLFAFPGILLAIAVVAILGSGMANVI-------IAVAIFSIPA- 176

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2104000359  95 faIARLVEQN-LMSIDPGVIEAARAMGASPWRIIRTVVVPEALGPLVLGYT 144
Cdd:PRK15082  177 --FARLVRGNtLVLKQQTYIESARSIGASDWTILLRHILPGTVSSIVVYFT 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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