|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
143-462 |
2.41e-76 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 243.28 E-value: 2.41e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 143 VFAEYVYVSDRIELMQAFDLLRQGEDKASAELRFETGAKSRPAQFMHARIEMTAIRSTAGRLRRVVAQLSDVTEIELLRR 222
Cdd:COG0642 15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 223 DVARKAAEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEyfgrlENDRQREYVGLIRQSGAHLLSVVNTMLDMSK 302
Cdd:COG0642 95 LLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-----LDEEQREYLETILRSADRLLRLINDLLDLSR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 303 LEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDA 382
Cdd:COG0642 170 LEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 383 AREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNeyTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPA 462
Cdd:COG0642 250 RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
224-465 |
2.00e-72 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 229.79 E-value: 2.00e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 224 VARKAAEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEyfGRLENDRQREYVGLIRQSGAHLLSVVNTMLDMSKL 303
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDE--EDLSPEERRELLEIIRESAERLLRLIEDLLDLSRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 304 EAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAA 383
Cdd:COG2205 80 ESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 384 REGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNeyTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPAD 463
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
..
gi 2105929845 464 GS 465
Cdd:COG2205 238 ES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
68-462 |
4.20e-69 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 226.36 E-value: 4.20e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 68 LVLALFLSAAAVSIAFSRPLHGSASSSAPAADDDLVAASQVPGLVLTINENGLVERVSGRDREKFPAELQACKDHVFAEY 147
Cdd:COG5002 1 LLLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 148 VYVSDRIELMQAFDLLRQGEDKASAELRFETGAksRPAQFMHARIEMTAIRSTAGRLRRVVAQLSDVTEIELLRRDVArk 227
Cdd:COG5002 81 LALLLLALLLLLLLLLLLLALLILLLLLALLIL--LAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDIT-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 228 aaEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEyfGRLENDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAGR 307
Cdd:COG5002 157 --ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDG--AADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 308 YELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGK 387
Cdd:COG5002 233 LKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDD 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2105929845 388 MLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPA 462
Cdd:COG5002 313 QVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
218-483 |
1.00e-52 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 192.30 E-value: 1.00e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 218 ELLRRDVARkaAEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEYFgrleNDRQREYVGLIRQSGAHLLSVVNTM 297
Cdd:TIGR02956 446 EVKNHAKAR--AEAEEANRAKSAFLATMSHEIRTPLNGILGTLELLGDTGL----TSQQQQYLQVINRSGESLLDILNDI 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 298 LDMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGE-ISADQRAIRQVLINLAGNAIKFTDAGG 376
Cdd:TIGR02956 520 LDYSKIEAGHLSISPRPFDLNALLDDVHHLMVSRAQLKGIQLRLNIPEQLPNwWQGDGPRIRQVLINLVGNAIKFTDRGS 599
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 377 VVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEytRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVV 456
Cdd:TIGR02956 600 VVLRVSLNDDSSLLFEVEDTGCGIAEEEQATLFDAFTQADGR--RRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCF 677
|
250 260
....*....|....*....|....*..
gi 2105929845 457 TIMLPADGSGMAggEDAETERMVEFPP 483
Cdd:TIGR02956 678 WFTLPLTRGKPA--EDSATLTVIDLPP 702
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
15-462 |
3.17e-49 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 176.51 E-value: 3.17e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 15 RWLARMEEDAERRAGTIARLRRLIAFGAVGLLVVPALFSLVFSPAIALPIGAALVLALFLSAAAVSIAFSRPLHGSASSS 94
Cdd:COG4251 55 LLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLAL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 95 APAADDDLVAASQVPGLVLTINENGLVERVSGRDREKFPAELQACKDHVFAEYVYVSDRIELMQAFDLLRQGEDKASAEL 174
Cdd:COG4251 135 LLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLE 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 175 RFETGAKSRPAQFMHARIEMTAIRSTAGRLRRVVAQLSDVTEIELLR----RDVARKAAEAESANDAKSRFLAAVSHELR 250
Cdd:COG4251 215 AELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELeeleEELEERTAELERSNEELEQFAYVASHDLR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 251 TPLNAVLGFSDILAGEYFGRLeNDRQREYVGLIRQSGAHLLSVVNTMLDMSKLeaGRYELLMESFPIAETISSCEAMLGL 330
Cdd:COG4251 295 EPLRKISGFSQLLEEDYGDKL-DEEGREYLERIRDAAERMQALIDDLLAYSRV--GRQELEFEPVDLNELLEEVLEDLEP 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 331 QAKEKGLTLTSriqRGIGEISADQRAIRQVLINLAGNAIKFTDAG--GVVSIDAAREGKMLKLTVSDTGIGIASDKIDLL 408
Cdd:COG4251 372 RIEERGAEIEV---GPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKI 448
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 2105929845 409 GQPFMQVQNEytRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPA 462
Cdd:COG4251 449 FEIFQRLHSR--DEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
217-477 |
7.90e-47 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 174.65 E-value: 7.90e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 217 IELlrrDVARKaaEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILageyfgrLE---NDRQREYVGLIRQSGAHLLSV 293
Cdd:PRK11107 277 VEL---DLAKK--RAQEAARIKSEFLANMSHELRTPLNGVIGFTRQT-------LKtplTPTQRDYLQTIERSANNLLAI 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 294 VNTMLDMSKLEAGRyeLLMES--FPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGE-ISADQRAIRQVLINLAGNAIK 370
Cdd:PRK11107 345 INDILDFSKLEAGK--LVLENipFSLRETLDEVVTLLAHSAHEKGLELTLNIDPDVPDnVIGDPLRLQQIITNLVGNAIK 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 371 FTDAGGV---VSIDAAREGKM-LKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGTFVI 446
Cdd:PRK11107 423 FTESGNIdilVELRALSNTKVqLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISF 502
|
250 260 270
....*....|....*....|....*....|.
gi 2105929845 447 ASQPGEGTVVTIMLPADGSGMAGGEDAETER 477
Cdd:PRK11107 503 HSQPNRGSTFWFHLPLDLNPNPIIDGLPTDC 533
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
104-461 |
2.17e-46 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 168.61 E-value: 2.17e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 104 AASQVPGLVLTINENGLVERVSGRDREKFPAELQACKDHVFAEYVYVSDRIELMQAFDLLRQGEDKASAELRFETGAKSR 183
Cdd:COG5809 146 IFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQLLKDGGIAQGEVRFWTKDGRW 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 184 paqfmharIEMTAIRSTAGRLRRVVAQLS---DVTE----IELLRRdvarkaaeAESANDAkSRFLAAVSHELRTPLNAV 256
Cdd:COG5809 226 --------RLLEASGAPIKKNGEVDGIVIifrDITErkklEELLRK--------SEKLSVV-GELAAGIAHEIRNPLTSL 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 257 LGFSDILAGEyfgrlENDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAGRYELlmesFPIAETISSCEAMLGLQAKEKG 336
Cdd:COG5809 289 KGFIQLLKDT-----IDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYEP----KDLNTLIEEVIPLLQPQALLKN 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 337 LTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAR-EGKMLKLTVSDTGIGIASDKIDLLGQPFmqv 415
Cdd:COG5809 360 VQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAeDDDKVVISVTDEGCGIPEERLKKLGEPF--- 436
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2105929845 416 qneYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:COG5809 437 ---YTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
225-461 |
1.61e-45 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 170.98 E-value: 1.61e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 225 ARKaaEAESANDAKSRFLAAVSHELRTPLNAVLGfsdilAGEYFGRLEND-RQREYVGLIRQSGAHLLSVVNTMLDMSKL 303
Cdd:PRK15347 387 AKQ--RAEQANKRKSEHLTTISHEIRTPLNGVLG-----ALELLQNTPLTaEQMDLADTARQCTLSLLAIINNLLDFSRI 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 304 EAGRYELLMESFPIAETISscEAMLGLQ--AKEKGLTLTSRIQRGIG-EISADQRAIRQVLINLAGNAIKFTDAGGvVSI 380
Cdd:PRK15347 460 ESGQMTLSLEETALLPLLD--QAMLTIQgpAQSKSLTLRTFVGAHVPlYLHLDSLRLRQILVNLLGNAVKFTETGG-IRL 536
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 381 DAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEytrrYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIML 460
Cdd:PRK15347 537 RVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612
|
.
gi 2105929845 461 P 461
Cdd:PRK15347 613 P 613
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
106-466 |
5.66e-43 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 157.82 E-value: 5.66e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 106 SQVPGLVLTINENGLVERVSGRDREKFPAELQACKDHVFAEyvyVSDRIELMQAFDLLRQGEDKASAELRFETGaksrpa 185
Cdd:COG5000 97 ENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEE---LLPELDLAELLREALERGWQEEIELTRDGR------ 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 186 qfmhariEMTAIRSTAGRLRRVVAQLSDVTEieLLRRDvaRKAAEAEsandaksrfLAA-VSHELRTPLNAVLGFSDILA 264
Cdd:COG5000 168 -------RTLLVRASPLRDDGYVIVFDDITE--LLRAE--RLAAWGE---------LARrIAHEIKNPLTPIQLSAERLR 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 265 GEYFGRLENDRQ--REYVGLIRQSGAHLLSVVNTMLDMSKLEagryELLMESFPIAETISSCEAMLGLQAKEKGLTLTSR 342
Cdd:COG5000 228 RKLADKLEEDREdlERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELD 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 343 IQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRR 422
Cdd:COG5000 304 LDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPF------FTTK 377
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2105929845 423 YEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPADGSG 466
Cdd:COG5000 378 PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
107-462 |
2.89e-42 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 154.23 E-value: 2.89e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 107 QVPGLVLTINENGLV-------ERVSGRDREkfpaELQACK-DHVFAEYVYVSDRIElmqafDLLRQGEDKASAELRFET 178
Cdd:COG3852 15 SLPDAVIVLDADGRItyvnpaaERLLGLSAE----ELLGRPlAELFPEDSPLRELLE-----RALAEGQPVTEREVTLRR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 179 GAKSRpaqfMHARIEMTAIRSTAGRlRRVVAQLSDVTEIELLRRDVARKAAeAESAndakSRFLAAVSHELRTPLNAVLG 258
Cdd:COG3852 86 KDGEE----RPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRRAEK-LAAV----GELAAGLAHEIRNPLTGIRG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 259 FSDILAGEyfgrLENDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAGRyellMESFPIAETISSCEAMLGLQAKeKGLT 338
Cdd:COG3852 156 AAQLLERE----LPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPE----REPVNLHEVLERVLELLRAEAP-KNIR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 339 LTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSI----------DAAREGKMLKLTVSDTGIGIASDKIDLL 408
Cdd:COG3852 227 IVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIrtrverqvtlGGLRPRLYVRIEVIDNGPGIPEEILDRI 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2105929845 409 GQPFmqvqneYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPA 462
Cdd:COG3852 307 FEPF------FTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPL 354
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
111-462 |
5.68e-42 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 153.42 E-value: 5.68e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 111 LVLTINENGLVERVSGRDREKFPAELQACKDHVFAEYVYVSDRIELMQAFDLLRQGEDKASAELRFETGAKSRPAQFMHA 190
Cdd:COG4191 3 RLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 191 RIEMTAIRSTAGRLRRVVAQLSDVTEIELLRRDVARKAAEAESANDAKSRFL------------AAVSHELRTPLNAVLG 258
Cdd:COG4191 83 GLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVqseklaalgelaAGIAHEINNPLAAILG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 259 FSDILAGEYFGRLENDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAGRyellMESFPIAETISSCEAMLGLQAKEKGLT 338
Cdd:COG4191 163 NAELLRRRLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALELLRPRLKARGIE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 339 LTSRIQRGIGEISADQRAIRQVLINLAGNAIkftDA-----GGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFm 413
Cdd:COG4191 239 VELDLPPDLPPVLGDPGQLEQVLLNLLINAI---DAmeegeGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPF- 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2105929845 414 qvqneYT--RRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPA 462
Cdd:COG4191 315 -----FTtkPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
357-461 |
1.30e-41 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 144.56 E-value: 1.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFTDAGGV---VSIDAAREGK-MLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSL 432
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVtlrVSLEEEEEDGvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 2105929845 433 VKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
207-458 |
1.24e-38 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 143.50 E-value: 1.24e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 207 VVAQlsDVTEIELL---RRDvarkaaeaesandaksrFLAAVSHELRTPLNAVLGFSDILAGEyfGRLENDRQREYVGLI 283
Cdd:TIGR02966 99 LVAR--DVTRLRRLeqmRRD-----------------FVANVSHELRTPLTVLRGYLETLADG--PDEDPEEWNRALEIM 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 284 RQSGAHLLSVVNTMLDMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIgEISADQRAIRQVLIN 363
Cdd:TIGR02966 158 LEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGV-DVLGDEDELRSAFSN 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 364 LAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGT 443
Cdd:TIGR02966 237 LVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHAR 316
|
250
....*....|....*
gi 2105929845 444 FVIASQPGEGTVVTI 458
Cdd:TIGR02966 317 LEIESELGKGSTFSF 331
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
222-479 |
1.97e-36 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 143.54 E-value: 1.97e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 222 RDVA-RKAAE--AESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEyfgRLeNDRQREYVGLIRQSGAHLLSVVNTML 298
Cdd:PRK11091 264 RDITeRKRYQdaLEKASRDKTTFISTISHELRTPLNGIVGLSRILLDT---EL-TAEQRKYLKTIHVSAITLGNIFNDII 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 299 DMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGE-ISADQRAIRQVLINLAGNAIKFTDAGGV 377
Cdd:PRK11091 340 DMDKMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLPHkVITDGTRLRQILWNLISNAVKFTQQGGV 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 378 VSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEY-TRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVV 456
Cdd:PRK11091 420 TVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHgGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCF 499
|
250 260
....*....|....*....|...
gi 2105929845 457 TIMLPADGSGMAGGEDAETERMV 479
Cdd:PRK11091 500 TLTIHAPAVAEEVEDAFDEDDMP 522
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
352-461 |
1.20e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 125.84 E-value: 1.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 352 ADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEyTRRYEGTGLGLS 431
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKR-SRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 2105929845 432 LVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
194-461 |
1.60e-34 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 138.11 E-value: 1.60e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 194 MTAIRSTAGRLRRVVAQLSD-----VTEIELLRRDVARKAAEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEYF 268
Cdd:PRK11466 395 MDAFRSNVHALNRHREQLAAqvkarTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPA 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 269 grleNDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAGRYELLM--ESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRG 346
Cdd:PRK11466 475 ----LNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVsdEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADD 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 347 I-GEISADQRAIRQVLINLAGNAIKFTDAgGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVqneyTRRYEG 425
Cdd:PRK11466 551 LpTALMGDPRRIRQVITNLLSNALRFTDE-GSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGG 625
|
250 260 270
....*....|....*....|....*....|....*.
gi 2105929845 426 TGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:PRK11466 626 TGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
228-461 |
1.10e-33 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 135.87 E-value: 1.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 228 AAEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEyfgRLENDRQReYVGLIRQSGAHLLSVVNTMLDMSKLEAGR 307
Cdd:PRK10841 437 AQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTK---ELPKGVDR-LVTAMNNSSSLLLKIISDILDFSKIESEQ 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 308 YELLMESFPIAETISSCEA-MLGLQAKeKGLTLTSRIQRGIGE-ISADQRAIRQVLINLAGNAIKFTDAGGVVsIDAARE 385
Cdd:PRK10841 513 LKIEPREFSPREVINHITAnYLPLVVK-KRLGLYCFIEPDVPVaLNGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVD 590
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2105929845 386 GKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:PRK10841 591 GDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
109-461 |
6.10e-31 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 125.61 E-value: 6.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 109 PGLVLTINENGLVERVSgrdrEKFPAELQACKDHV----FAEYVYVSDRIELMQAFDLLRQGEDKASAELRFETgaKSRP 184
Cdd:COG5805 167 PDLICVIDTDGRILFIN----ESIERLFGAPREELigknLLELLHPCDKEEFKERIESITEVWQEFIIEREIIT--KDGR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 185 AQFMHARIemTAIRSTAGRLRRVVAQLSDVTEiellrrdvaRKAAEAESANDAKSRF---LAA-VSHELRTPLNAVLGFS 260
Cdd:COG5805 241 IRYFEAVI--VPLIDTDGSVKGILVILRDITE---------KKEAEELMARSEKLSIagqLAAgIAHEIRNPLTSIKGFL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 261 DILageyfgRLENDRQREYVglirqsgahllsvvNTMLD-MSKLEAGRYELLMESFP---------IAETISSCEAMLGL 330
Cdd:COG5805 310 QLL------QPGIEDKEEYF--------------DIMLSeLDRIESIISEFLALAKPqavnkekenINELIQDVVTLLET 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 331 QAKEKGLTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQ 410
Cdd:COG5805 370 EAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGE 449
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2105929845 411 PFmqvqneYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:COG5805 450 PF------FTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
213-488 |
1.29e-30 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 126.77 E-value: 1.29e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 213 DVTEIELLRRDVARKAAEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILAGEyfgRLENDRQREYVGLIRQSGAHLLS 292
Cdd:PRK09959 687 DITETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGS---GLSKEQRVEAISLAYATGQSLLG 763
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 293 VVNTMLDMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLT-SRIQRGIGEISADQRAIRQVLINLAGNAIKF 371
Cdd:PRK09959 764 LIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScSSTFPDHYLVKIDPQAFKQVLSNLLSNALKF 843
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 372 TDAGGV------VSIDAARegKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNeyTRRYEGTGLGLSLVKGLVALHGGTFV 445
Cdd:PRK09959 844 TTEGAVkittslGHIDDNH--AVIKMTIMDSGSGLSQEEQQQLFKRYSQTSA--GRQQTGSGLGLMICKELIKNMQGDLS 919
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2105929845 446 IASQPGEGTVVTIMLPADGSGMAGGEDAETERMVEFPPRIRQL 488
Cdd:PRK09959 920 LESHPGIGTTFTITIPVEISQQVATVEAKAEQPITLPEKLSIL 962
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
352-463 |
3.84e-29 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 110.54 E-value: 3.84e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 352 ADQRAIRQVLINLAGNAIKFTDAGGVVSIDAaREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVqneYTRRYEGTGLGLS 431
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTA---DKRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|..
gi 2105929845 432 LVKGLVALHGGTFVIASQPGEGTVVTIMLPAD 463
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
357-460 |
1.39e-28 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 108.84 E-value: 1.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNeyTRRYEGTGLGLSLVKGL 436
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 2105929845 437 VALHGGTFVIASQPGEGTVVTIML 460
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
208-461 |
6.39e-27 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 114.46 E-value: 6.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 208 VAQLSDVTE---IELLRRDvarkaaeaesandaksrFLAAVSHELRTPLNAVLGFSDIL----------AGEYFG--RLE 272
Cdd:NF033092 356 IAVLHDVTEqekIEQERRE-----------------FVANVSHELRTPLTTMRSYLEALadgawkdpelAPRFLGvtQNE 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 273 NDRqreyvgLIRqsgahllsVVNTMLDMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGEISA 352
Cdd:NF033092 419 TER------MIR--------LVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRDLWVEI 484
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSL 432
Cdd:NF033092 485 DTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAI 564
|
250 260
....*....|....*....|....*....
gi 2105929845 433 VKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:NF033092 565 AKEVVEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
218-464 |
1.60e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 112.19 E-value: 1.60e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 218 ELLRRDVARKAAEAESANDAksrflAAVSHELRTPLNAVLGFSdilagEYFGRL--ENDRQREYVGLIRQSGAHLLSVVN 295
Cdd:PRK10364 222 QLLQDEMKRKEKLVALGHLA-----AGVAHEIRNPLSSIKGLA-----KYFAERapAGGEAHQLAQVMAKEADRLNRVVS 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 296 TMLDMSKLEagryELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAG 375
Cdd:PRK10364 292 ELLELVKPT----HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQH 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 376 GVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTV 455
Cdd:PRK10364 368 GVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPY------FTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGAT 441
|
....*....
gi 2105929845 456 VTIMLPADG 464
Cdd:PRK10364 442 FTLWLPVNI 450
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
210-461 |
1.19e-24 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 105.42 E-value: 1.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 210 QLSDvtEIELLRRDVARKAAEAESandaKSRFLAAVSHELRTPLNAVLgfsdiLAGEyfgRLENDRQREYVGLIRQSGAH 289
Cdd:PRK09303 129 QLSD--ELFVLRQENETLLEQLKF----KDRVLAMLAHDLRTPLTAAS-----LALE---TLELGQIDEDTELKPALIEQ 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 290 LLSVVNTMLD----MSK--LEAGRY---ELLMESFPIAETISSCEAMLGLQA--KEKGLTLTSRIQRGIGEISADQRAIR 358
Cdd:PRK09303 195 LQDQARRQLEeierLITdlLEVGRTrweALRFNPQKLDLGSLCQEVILELEKrwLAKSLEIQTDIPSDLPSVYADQERIR 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINLAGNAIKFTDAGGVVSIDAA-REGKMLKLTVSDTGIGIASDKID--LLGQPFMQvQNEYTrryEGTGLGLSLVKG 435
Cdd:PRK09303 275 QVLLNLLDNAIKYTPEGGTITLSMLhRTTQKVQVSICDTGPGIPEEEQEriFEDRVRLP-RDEGT---EGYGIGLSVCRR 350
|
250 260
....*....|....*....|....*.
gi 2105929845 436 LVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:PRK09303 351 IVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
207-461 |
1.29e-24 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 107.36 E-value: 1.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 207 VVAQLSDVTEIELLRRDVARKAAEAesandAKSRFLAAVSHELRTPLNAVLGFSDILAGEYFGRlendRQREYVGLIRQS 286
Cdd:PRK11360 364 ALVIFSDLTERKRLQRRVARQERLA-----ALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP----PSQEYLSVVLRE 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 287 GAHLLSVVNTMLDMSKLEAGRyellMESFPIAETIsscEAMLGLQA---KEKGLTLTSRIQRGIGEISADQRAIRQVLIN 363
Cdd:PRK11360 435 VDRLNKVIDQLLEFSRPRESQ----WQPVSLNALV---EEVLQLFQtagVQARVDFETELDNELPPIWADPELLKQVLLN 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 364 LAGNAIKFTDAGGVVSIDAAREG-KMLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRYEGTGLGLSLVKGLVALHGG 442
Cdd:PRK11360 508 ILINAVQAISARGKIRIRTWQYSdGQVAVSIEDNGCGIDPELLKKIFDPF------FTTKAKGTGLGLALSQRIINAHGG 581
|
250
....*....|....*....
gi 2105929845 443 TFVIASQPGEGTVVTIMLP 461
Cdd:PRK11360 582 DIEVESEPGVGTTFTLYLP 600
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
247-464 |
2.88e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 105.70 E-value: 2.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 247 HELRTPLNAVLGFSDILAGEYfgrLENDRQReYVGLIRQSGAHLLSVVNTMLDMSKLEAGRYELLMESFPIAETISSCEA 326
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDP---PPEDRAR-FTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVE 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 327 MLGLQAKEKGLTLTSRIQRGigEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKID 406
Cdd:PRK11100 341 AREAQAAAKGITLRLRPDDA--RVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALP 418
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2105929845 407 LLGQPFMQVQNEYTRRyEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPADG 464
Cdd:PRK11100 419 RIFERFYSLPRPANGR-KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
225-461 |
8.19e-24 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 105.50 E-value: 8.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 225 ARKAAEAESANDAksrFLAAVSHELRTPLNAVLGFSDILAGEYfgRLENDRQREYVGLIRQsgaHLLS---VVNTMLDMS 301
Cdd:PRK10490 654 ARLASEREQLRNA---LLAALSHDLRTPLTVLFGQAEILTLDL--ASEGSPHARQASEIRQ---QVLNttrLVNNLLDMA 725
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 302 KLEAGRYELLMESFPIAETISSCEAMLglqakEKGL---TLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVV 378
Cdd:PRK10490 726 RIQSGGFNLRKEWLTLEEVVGSALQML-----EPGLsghPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEI 800
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 379 SIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTrrYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTI 458
Cdd:PRK10490 801 GIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878
|
...
gi 2105929845 459 MLP 461
Cdd:PRK10490 879 TLP 881
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
206-461 |
2.62e-23 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 102.60 E-value: 2.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 206 RVVAQLSDvtEIELLRRDVARKAAEAESANDAKSRFLAAVSHELRTPLnAVLGfsdilageyfGRLE--NDRQREY---- 279
Cdd:NF012163 210 RVTPTSND--ELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPL-AVLR----------AELEaiQDGIRKFtpes 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 280 -VGLIRQSGAhLLSVVNTMLDMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQrGIGEISADQRAIR 358
Cdd:NF012163 277 lDSLQAEVGT-LTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLP-DSSLVFGDRDRLM 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVA 438
Cdd:NF012163 355 QLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQ 434
|
250 260
....*....|....*....|...
gi 2105929845 439 LHGGTFVIASQPGEGTVVTIMLP 461
Cdd:NF012163 435 AHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
353-461 |
6.54e-21 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 87.93 E-value: 6.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFTDAGGVVS--IDAAREGKMLkLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGL 430
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRciLEKFRLNRFL-LTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 2105929845 431 SLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-461 |
8.62e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 87.52 E-value: 8.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSL 432
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 2105929845 433 VKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
204-461 |
1.06e-19 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 91.68 E-value: 1.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 204 LRRVVAQLSDVTEIELLRR-DVARKAAE----AESANDA----------KSRFLAAVSHELRTPLNAVLGFSDILageyf 268
Cdd:TIGR01386 192 LRRLSAVAARISPESLDQRlDPSRAPAElrelAQSFNAMlgrledafqrLSQFSADLAHELRTPLTNLLGQTQVA----- 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 269 grLENDR-QREYVGLIRQSGAHL--LS-VVNTMLDMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTsriQ 344
Cdd:TIGR01386 267 --LSQPRtGEEYREVLESNLEELerLSrMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIR---V 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 345 RGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYE 424
Cdd:TIGR01386 342 EGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGE 421
|
250 260 270
....*....|....*....|....*....|....*..
gi 2105929845 425 GTGLGLSLVKGLVALHGGTfVIASQPGEGTVVTIMLP 461
Cdd:TIGR01386 422 GTGLGLAIVRSIMEAHGGR-ASAESPDGKTRFILRFP 457
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
45-465 |
1.15e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 90.68 E-value: 1.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 45 LLVVPALFSLVFSPAIALPIGAALVLALFLSAAAVSIAFSRPLHGSASSSAPAADDDLVAASQVPGLVLTINENGlverv 124
Cdd:COG3290 6 LLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIA----- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 125 sgRDREKFPAELQACKDHVFAeyVYVSDRIELM-----QAFDLLRQGEDKASAELRFETGAKSRPAQFMHARIEMTAIR- 198
Cdd:COG3290 81 --RLVEEREAVLESIREGVIA--VDRDGRITLIndaarRLLGLDAIGRPIDEVLAEVLETGERDEEILLNGRVLVVNRVp 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 199 -STAGRLRRVVAQLSDVTEIELLrrdvARKAAEAESANDAksrfLAAVSHELRTPLNAVLGFSDIL----AGEYFGRLEN 273
Cdd:COG3290 157 iRDDGRVVGAVATFRDRTELERL----EEELEGVKELAEA----LRAQRHDFRNHLHTISGLLQLGeydeALEYIDEISE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 274 DRQREYVGLIRQSGahllsvvNTMLD---MSKLEagryellmesfpiaetissceamlglQAKEKGLTLTSRIQRGIGEI 350
Cdd:COG3290 229 ELQELIDSLLSRIG-------NPVLAallLGKAA--------------------------RARERGIDLTIDIDSDLPDL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 351 SADQRAIRQVLINLAGNAI----KFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPfmqvqNEYTRRYEGT 426
Cdd:COG3290 276 PLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFER-----GFSTKLGEGR 350
|
410 420 430
....*....|....*....|....*....|....*....
gi 2105929845 427 GLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPADGS 465
Cdd:COG3290 351 GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
215-462 |
4.51e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 89.30 E-value: 4.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 215 TEIELLRrdVARKAAEAESANDAKSRFLAAVSHELRTPLNAVLGFsdilageyfgrLENDRQREYVGLIRQSGAHLL--- 291
Cdd:PRK11006 183 TEGQLLM--VARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGY-----------LEMMQDQPLEGALREKALHTMreq 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 292 -----SVVNTMLDMSKLEAGRYELLMESFPIAetissceAMLGLQAKEkGLTLTSRIQRGIGEIS------ADQRAIRQV 360
Cdd:PRK11006 250 tqrmeGLVKQLLTLSKIEAAPTIDLNEKVDVP-------MMLRVLERE-AQTLSQGKHTITFEVDnslkvfGNEDQLRSA 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 361 LINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALH 440
Cdd:PRK11006 322 ISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHH 401
|
250 260
....*....|....*....|..
gi 2105929845 441 GGTFVIASQPGEGTVVTIMLPA 462
Cdd:PRK11006 402 DSRLEIESEVGKGTRFSFVLPE 423
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
2.62e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 80.16 E-value: 2.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRY--EGTGLGLSLVK 434
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPF------FTTKPvgEGTGLGLSLSY 77
|
90 100
....*....|....*....|....*..
gi 2105929845 435 GLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
206-462 |
6.09e-18 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 85.05 E-value: 6.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 206 RVVAQLSDVTEIELLRRDVARKAAEAESANDAKSRFLAAVSHELRTPLNAVLG-FSDILAGEY------FGRLENdrQRE 278
Cdd:NF012226 106 RAEDSQIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQGrLQGILDGVFepdpalFKSLLN--QVE 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 279 yvGLirqsgAHLLSVVNTmldMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIgeISADQRAIR 358
Cdd:NF012226 184 --GL-----SHLVEDLRT---LSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNLTATP--VFCDRRRIE 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINLAGNAIKFTDAgGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVA 438
Cdd:NF012226 252 QVLIALIDNAIRYANA-GKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVI 330
|
250 260
....*....|....*....|....
gi 2105929845 439 LHGGTfVIASQPGEGTVVTIMLPA 462
Cdd:NF012226 331 AHKGS-IEYSNSQGNSVFTIKLPA 353
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
245-477 |
6.71e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 87.04 E-value: 6.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 245 VSHELRTPLNAVLGFSDIlAGEYFGRleNDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAGRYELLMESFPIAETISSC 324
Cdd:PRK13837 457 IAHNFNNILGAILGYAEM-ALNKLAR--HSRAARYIDEIISAGARARLIIDQILAFGRKGERNTKPFDLSELVTEIAPLL 533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 325 EAMLGlqakeKGLTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAARE---------------GKML 389
Cdd:PRK13837 534 RVSLP-----PGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAklrapkvlshgvlppGRYV 608
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 390 KLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPAdGSGMAG 469
Cdd:PRK13837 609 LLRVSDTGAGIDEAVLPHIFEPF------FTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP-SSKVPV 681
|
....*...
gi 2105929845 470 GEDAETER 477
Cdd:PRK13837 682 APQAFFGP 689
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
1.93e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 77.75 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFT--DAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLgqpFMQVQNEYTR-RYEGTGLGLSLV 433
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKV---FGIFQRLHSReEYEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 2105929845 434 KGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
195-462 |
4.91e-17 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 83.54 E-value: 4.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 195 TAIRSTAGRL-RRVVAQLSDvtEIELLRR-------DVARKAAEAESANDAKSRFLAAVSHELRTPLNAVLGFSDILage 266
Cdd:NF040691 222 TAERFAAGDLsERMPVKGED--DLARLARsfnqmadSLQRQIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVI--- 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 267 YFGRLEND-RQREYVGLIRQSGAHLLSVVNTMLDMSKLEAGRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQR 345
Cdd:NF040691 297 HDSRDDFDpATARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPG 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 346 GIGEISADQRAIRQVLINLAGNAIKFTDAGGVVsIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEG 425
Cdd:NF040691 377 TPVVAEVDPRRVERVLRNLVVNAIEHGEGKPVV-VTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGG 455
|
250 260 270
....*....|....*....|....*....|....*..
gi 2105929845 426 TGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPA 462
Cdd:NF040691 456 TGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPR 492
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
2.53e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 74.55 E-value: 2.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGL 436
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 2105929845 437 VALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
246-461 |
6.36e-16 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 80.56 E-value: 6.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 246 SHELRTPLNAVLGFSDILAgeyFGRLENDRQrEYVGLIRQSGAHLLSVVNTMLDMSKLEAGRYELLMESFPIAETISSCE 325
Cdd:TIGR03785 493 SHELRTPVAVVRSSLENLE---LQALEQEKQ-KYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCM 568
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 326 A---------MLGLQAKEKGLTLtsriqRGIGEIsadqraIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDT 396
Cdd:TIGR03785 569 QgyqmtyppqRFELNIPETPLVM-----RGSPEL------IAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNE 637
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2105929845 397 GIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGTFVIASQP-GEGTVVTIMLP 461
Cdd:TIGR03785 638 GPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISLP 703
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
237-306 |
8.60e-16 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 71.86 E-value: 8.60e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 237 AKSRFLAAVSHELRTPLNAVLGFSDILAGEyfgrLENDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAG 306
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDE----KLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-460 |
1.37e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 72.82 E-value: 1.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFTDAGGVVSID-AAREGKMLKltVSDTGIGIASDKIDLLGQPFMQVQneyTRRYEGTGLGLSLVKG 435
Cdd:cd16940 14 LFLLLRNLVDNAVRYSPQGSRVEIKlSADDGAVIR--VEDNGPGIDEEELEALFERFYRSD---GQNYGGSGLGLSIVKR 88
|
90 100
....*....|....*....|....*
gi 2105929845 436 LVALHGGTFVIASQPGEGTVVTIML 460
Cdd:cd16940 89 IVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
235-302 |
2.18e-15 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 70.70 E-value: 2.18e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2105929845 235 NDAKSRFLAAVSHELRTPLNAVLGFSDILAGEyfgRLENDRQREYVGLIRQSGAHLLSVVNTMLDMSK 302
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEE---LLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
237-306 |
1.18e-14 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 68.36 E-value: 1.18e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 237 AKSRFLAAVSHELRTPLNAVLGFSDILAGEYFgrleNDRQREYVGLIRQSGAHLLSVVNTMLDMSKLEAG 306
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTEL----SEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
2.64e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 68.96 E-value: 2.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFTDAGGV----VSIDAAREGK-MLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRYEGTGLGLS 431
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPF------YTTKSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 2105929845 432 LVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
3.83e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 68.24 E-value: 3.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFtdAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNeyTRRYEGTGLGLSLVKGL 436
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDN--ARGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 2105929845 437 VALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-462 |
4.74e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 68.12 E-value: 4.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINLAGNAIKFTDagGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVA 438
Cdd:cd16949 3 RALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 2105929845 439 LHGGTFVIASQPGEGTVVTIMLPA 462
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
359-461 |
4.85e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 68.56 E-value: 4.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINLAGNA---------------IKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRY 423
Cdd:cd16919 3 LAILNLAVNArdampeggrltietsNQRVDADYALNYRDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPF------FTTKE 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2105929845 424 EG--TGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16919 77 VGkgTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
206-461 |
9.41e-14 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 73.13 E-value: 9.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 206 RVVAQLSDvtEIELLRRDVARKAAEAESANDAKSRFLAAVSHELRTPLnAVLGfsdilageyfGRLE--NDRQREyvgLI 283
Cdd:PRK10549 210 RVTPTSRD--ELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPL-AVLR----------GELEaiQDGVRK---FT 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 284 RQSGAHLLSVVNTM---------LDMSKLEAGRYEllMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIgEISADQ 354
Cdd:PRK10549 274 PESVASLQAEVGTLtklvddlhqLSLSDEGALAYR--KTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSA-TVFGDP 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 355 RAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVK 434
Cdd:PRK10549 351 DRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICL 430
|
250 260
....*....|....*....|....*..
gi 2105929845 435 GLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:PRK10549 431 NIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
346-461 |
1.74e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 72.25 E-value: 1.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 346 GIGEISADQRAIRQVLINLAGNAIKFTdaGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFmqVQNEYTRRYEG 425
Cdd:PRK09467 321 GPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPF--TRGDSARGSSG 396
|
90 100 110
....*....|....*....|....*....|....*.
gi 2105929845 426 TGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:PRK09467 397 TGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-461 |
1.99e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 66.26 E-value: 1.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 358 RQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNeyTRRYEGTGLGLSLVKGLV 437
Cdd:cd16923 2 QRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 2105929845 438 ALHGGTFVIASQpGEGTVVTIMLP 461
Cdd:cd16923 80 ELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-460 |
3.91e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 66.00 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 352 ADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLS 431
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLT 95
|
90 100
....*....|....*....|....*....
gi 2105929845 432 LVKGLVALHGGTFVIASQPGEGTVVTIML 460
Cdd:cd16947 96 ITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-461 |
4.96e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 65.38 E-value: 4.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 356 AIRQVLINlagnAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRyEGTGLGLSLVKG 435
Cdd:cd16948 9 IIGQIVSN----ALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQ-ESTGMGLYLVKK 83
|
90 100
....*....|....*....|....*.
gi 2105929845 436 LVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16948 84 LCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-461 |
1.73e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 63.71 E-value: 1.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFTDAG------GVVSIDAAREGKmLKLTVSDTGIGIASDKIDLLGQPFMqvqneyTRRYEGT 426
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRpsdvgeVRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYV------TTRPKGT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 2105929845 427 GLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-460 |
5.71e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 62.09 E-value: 5.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIkftDAGGVV-----SIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRY--EGTGLG 429
Cdd:cd16976 1 IQQVLMNLLQNAL---DAMGKVenpriRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPF------FTTKPvgKGTGLG 71
|
90 100 110
....*....|....*....|....*....|.
gi 2105929845 430 LSLVKGLVALHGGTFVIASQPGEGTVVTIML 460
Cdd:cd16976 72 LSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-451 |
1.02e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 61.71 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRyEGTGLGLSL 432
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAF 79
|
90
....*....|....*....
gi 2105929845 433 VKGLVALHGGTFVIASQPG 451
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPD 98
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
244-461 |
1.03e-11 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 66.94 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 244 AVSHELRTPLnAVLGFsdilageyfgRLE---NDRQREYVGLIRQSGAhLLSVVNTMLDMSKLEAGRYELLMESFPIAET 320
Cdd:PRK10604 218 GIAHELRTPL-VRLRY----------RLEmsdNLSAAESQALNRDIGQ-LEALIEELLTYARLDRPQNELHLSEPDLPAW 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 321 ISscEAMLGLQA----KEKGLTLTSRIQRGIgeisADQRAIRQVLINLAGNAIKFtdAGGVVSIDAAREGKMLKLTVSDT 396
Cdd:PRK10604 286 LS--THLADIQAvtpeKTVRLDTPHQGDYGA----LDMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDD 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2105929845 397 GIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:PRK10604 358 GPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
236-461 |
1.15e-11 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 66.88 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 236 DAKSRFLAAVSHELRTPLnAVLGFSDILA----GEY--FGRLENDRQReyvglirqsgahLLSVVNTMLDMSKLEAgRYE 309
Cdd:PRK09470 241 TSQQRLLSDISHELRTPL-TRLQLATALLrrrqGESkeLERIETEAQR------------LDSMINDLLVLSRNQQ-KNH 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 310 LLMESFPIAETISSCEAMLGLQAKEKGLTLTSRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGkmL 389
Cdd:PRK09470 307 LERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDG--L 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2105929845 390 KLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGTfVIASQ-PGEGTVVTIMLP 461
Cdd:PRK09470 385 TITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGW-VKAEDsPLGGLRLTIWLP 456
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
377-480 |
1.16e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 67.00 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 377 VVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYtrryEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVV 456
Cdd:PRK13557 313 LAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEG----KGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTV 388
|
90 100
....*....|....*....|....
gi 2105929845 457 TIMLPADgSGMAGGEDAETERMVE 480
Cdd:PRK13557 389 RLYFPAS-DQAENPEQEPKARAID 411
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
238-461 |
1.22e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 66.72 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 238 KSRFLAAVSHELRTPLNAVLGFSDILageyfgrLENDR-QREYVGLIRQS---GAHLLSVVNTMLDMSKLEAGRYELLME 313
Cdd:PRK09835 262 QSNFSADIAHEIRTPITNLITQTEIA-------LSQSRsQKELEDVLYSNleeLTRMAKMVSDMLFLAQADNNQLIPEKK 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 314 SFPIAETISSCEAMLGLQAKEKGLTLtsRIQRGIGEISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTV 393
Cdd:PRK09835 335 MLDLADEVGKVFDFFEAWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVV 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2105929845 394 SDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPgEGTVVTIMLP 461
Cdd:PRK09835 413 ENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-458 |
1.60e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 60.94 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQvqnEYTRRYEGT--GLGL 430
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYR---DDTSRRSGGhyGMGL 77
|
90 100
....*....|....*....|....*...
gi 2105929845 431 SLVKGLVALHGGTFVIASQPGEGTVVTI 458
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
241-463 |
4.06e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 64.60 E-value: 4.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 241 FLAAVSHELRTPLNAVlgfsdilageyfgrlendrqREYVGLIRQSGA-----------HLLSVVNTMLDMSKLE----A 305
Cdd:PRK10755 140 FTADVAHELRTPLAGI--------------------RLHLELLEKQHHidvapliarldQMMHTVEQLLQLARAGqsfsS 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 306 GRYE--LLMESFpIAETISSCEAMLglQAKEKGLTLTSRIQRGIgeISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAA 383
Cdd:PRK10755 200 GHYQtvKLLEDV-ILPSQDELSEML--EQRQQTLLLPESAADIT--VQGDATLLRLLLRNLVENAHRYSPEGSTITIKLS 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 384 REGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQneytRRYEGTGLGLSLVKGLVALHGGTFVIAS-QPGEGTVVTIMLPA 462
Cdd:PRK10755 275 QEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLPK 350
|
.
gi 2105929845 463 D 463
Cdd:PRK10755 351 A 351
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
7.47e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 58.95 E-value: 7.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINLAGNAIKFTDAGG-----------VVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMqvqneyTRRYEGTG 427
Cdd:cd16918 3 QVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV------SGRENGTG 76
|
90 100 110
....*....|....*....|....*....|....
gi 2105929845 428 LGLSLVKGLVALHGGTFVIASQPGEgTVVTIMLP 461
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
367-461 |
1.07e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 63.50 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 367 NAIKF----TDAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDllgqpfmQVQNEYTRRYEGTGLGLSLVKGLVALH-- 440
Cdd:COG2972 347 NAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLE-------KLLEELSSKGEGRGIGLRNVRERLKLYyg 419
|
90 100
....*....|....*....|..
gi 2105929845 441 -GGTFVIASQPGEGTVVTIMLP 461
Cdd:COG2972 420 eEYGLEIESEPGEGTTVTIRIP 441
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
210-461 |
3.79e-10 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 62.64 E-value: 3.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 210 QLSDVTEIELLR-RD----VARKAAEAESAND----AKSRFLAAVSHELRTPLNAVlgfsDILAGEYFGRLENDRQREYV 280
Cdd:PRK10618 413 QLAPRTQLFLLRdQDrevlVNKKLQQAQREYEknqqARKAFLQNIGDELKQPLQSL----AQLAAQLRQTSDEEQQQPEL 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 281 GLIRQSGAHLLSVVNTMLDMSKLEAGRYELLMESFPIAETIsscEAMLG--LQA-KEKGLTLTSRIQRGIGEI-SADQRA 356
Cdd:PRK10618 489 DQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLI---DEVLPevLPAiKRKGLQLLIHNHLKAEQLrIGDRDA 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 357 IRQVLINLAGNAIKFTDAGGV---VSIDAAREGKmLKLTVSDTGIGIASDKIDLLGQPFM-QVQNEytRRYEGTGLGLSL 432
Cdd:PRK10618 566 LRKILLLLLNYAITTTAYGKItleVDQDESSPDR-LTIRILDTGAGVSIKELDNLHFPFLnQTQGD--RYGKASGLTFFL 642
|
250 260
....*....|....*....|....*....
gi 2105929845 433 VKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:PRK10618 643 CNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
215-461 |
4.46e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 62.01 E-value: 4.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 215 TEIE-LLRRDVARKAAEAESANDAKsrfLAAV-------SHELRTPLNAV--LGFSDILAGEYfgrlENDRQ-REYVGLI 283
Cdd:COG4192 405 TEIEeRKRIEKNLRQTQDELIQAAK---MAVVgqtmtslAHELNQPLNAMsmYLFSAKKALEQ----ENYAQlPTSLDKI 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 284 RQSGAHLLSVVNTMLDMSKleagRYELLMESFPIAETISSCEAMLGLQAKEKGLTLTsriQRGIGEISADQRAIRQVLIN 363
Cdd:COG4192 478 EGLIERMDKIIKSLRQFSR----KSDTPLQPVDLRQVIEQAWELVESRAKPQQITLH---IPDDLMVQGDQVLLEQVLVN 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 364 LAGNAIKFTDAGGVVSIDAAREGKMLKLTVSDTGIGIASdkIDLLGQPFmqvqneYTRRYEGTGLGLSLVKGLVALHGGT 443
Cdd:COG4192 551 LLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPF------TTTKEVGLGLGLSICRSIMQQFGGD 622
|
250
....*....|....*...
gi 2105929845 444 FVIASQPGEGTVVTIMLP 461
Cdd:COG4192 623 LYLASTLERGAMVILEFN 640
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
7.28e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 56.28 E-value: 7.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 360 VLINLAGNAIKFTDAggVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQNEYTRRYEGTGLGLSLVKGLVAL 439
Cdd:cd16939 4 ALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|...
gi 2105929845 440 HGGTFVIASQPGEGTVVTIMLPA 462
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
1.33e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.66 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINLAGNAIKFT-DAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFmqvqneYTRRYEG------TGLGLS 431
Cdd:cd16953 3 QVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRF------YTERPANeafgqhSGLGLS 76
|
90 100 110
....*....|....*....|....*....|....
gi 2105929845 432 LVKGLVALHGGTFV--IASQPGE--GTVVTIMLP 461
Cdd:cd16953 77 ISRQIIEAHGGISVaeNHNQPGQviGARFTVQLP 110
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-461 |
5.74e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 53.45 E-value: 5.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 363 NLAGNAIKFT----DAGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLlgqpfMQVQNEYTRRYEGTGLGLSLVKGLVA 438
Cdd:cd16915 7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDK-----VFERGVSTKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 2105929845 439 LHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
240-458 |
1.38e-08 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 56.97 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 240 RFLAAVSHELRTPLNAVLGFSDI--LAGEYFGRLENDRQREYVGLIRQSgahllSVVNTMLDMSKLEAGRYELLMESFPI 317
Cdd:PRK10337 239 RFTSDAAHELRSPLAALKVQTEVaqLSDDDPQARKKALLQLHAGIDRAT-----RLVDQLLTLSRLDSLDNLQDVAEIPL 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 318 AETISSCEAMLGLQAKEKGLTLTSRIQrgigeisaDQRAIRQ-------VLI-NLAGNAIKFTDAGGVVSID-AAREgkm 388
Cdd:PRK10337 314 EDLLQSAVMDIYHTAQQAGIDVRLTLN--------AHPVIRTgqplllsLLVrNLLDNAIRYSPQGSVVDVTlNARN--- 382
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2105929845 389 lkLTVSDTGIGIASDKIDLLGQPFM----QVQNeytrryeGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTI 458
Cdd:PRK10337 383 --FTVRDNGPGVTPEALARIGERFYrppgQEAT-------GSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
378-465 |
4.71e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.16 E-value: 4.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 378 VSIDAAREGKMLKLTVSDTGIGIASDKIdllgqpfmqvqneytrryEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVT 457
Cdd:COG4585 183 VTVTLEVDDGELTLTVRDDGVGFDPEAA------------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVR 244
|
....*...
gi 2105929845 458 IMLPADGS 465
Cdd:COG4585 245 ATLPLAAA 252
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
332-464 |
1.54e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 50.68 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 332 AKEKGLTLTsriqrgIGEIS----ADQRAIRQVLI----NLAGNAIkftDA-----GGVVSIDAAREGKMLKLTVSDTGI 398
Cdd:PRK11086 407 ARELGITLI------ISEDSqlpdSGDEDQVHELItilgNLIENAL---EAvggeeGGEISVSLHYRNGWLHCEVSDDGP 477
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2105929845 399 GIASDKIDllgQPFMQvqnEYTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLPADG 464
Cdd:PRK11086 478 GIAPDEID---AIFDK---GYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDG 537
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
240-461 |
1.94e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 50.08 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 240 RFLAavsHELRTPLNAVLGFSDILAGEyfgrLENDRQREYVGLIRQSGAHLLSVVNTMLDMSKLeaGRYellmesfpIAE 319
Cdd:PRK11073 135 RGLA---HEIKNPLGGLRGAAQLLSKA----LPDPALTEYTKVIIEQADRLRNLVDRLLGPQRP--GTH--------VTE 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 320 TISS-CEAMLGLQAKEKGLTLTsrIQR----GIGEISADQRAIRQVLINLAGNAIK-FTDAGGVVSI------DAAREGK 387
Cdd:PRK11073 198 SIHKvAERVVQLVSLELPDNVR--LIRdydpSLPELAHDPDQIEQVLLNIVRNALQaLGPEGGTITLrtrtafQLTLHGE 275
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2105929845 388 MLKLT----VSDTGIGIASDKIDLLGQPFMqvqneyTRRYEGTGLGLSLVKGLVALHGGTFVIASQPGEgTVVTIMLP 461
Cdd:PRK11073 276 RYRLAaridIEDNGPGIPPHLQDTLFYPMV------SGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
364-463 |
2.05e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.29 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 364 LAGNAIKF---TDAGGVVSIDAAREGKMLKLTVSDTGIGIASDkidllgqpfmqvqneyTRRYEGTGLGLSLVKGLVALH 440
Cdd:COG3920 407 LVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED----------------VDPPARKGLGLRLIRALVRQL 470
|
90 100
....*....|....*....|...
gi 2105929845 441 GGTFVIASqpGEGTVVTIMLPAD 463
Cdd:COG3920 471 GGTLELDR--PEGTRVRITFPLA 491
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
350-460 |
4.74e-06 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 45.91 E-value: 4.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 350 ISADQRAIRQVLINLAGNAIKFTDAGGVVSIDAAREG----------KMLKLTVSDTGIGIASD-KIDLLGQPF---MQV 415
Cdd:cd16938 5 VVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEGgsedrsdrdwGPWRPSMSDESVEIRFEvEINDSGSPSiesASM 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2105929845 416 QNEYTRRY----EGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIML 460
Cdd:cd16938 85 RNSLNRRYnlseLGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
6.03e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 45.11 E-value: 6.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 359 QVLINlagNAIK--FTD--AGGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQpfMQVQNEytrryEGTGLGL-SLV 433
Cdd:cd16957 7 QVLVE---NAIRhaFPKrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGK--TTVTSE-----KGTGTALeNLN 76
|
90 100 110
....*....|....*....|....*....|
gi 2105929845 434 KGLVALHG--GTFVIASQPGEGTVVTIMLP 461
Cdd:cd16957 77 RRLIGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-461 |
9.95e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 44.36 E-value: 9.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 364 LAGNAIK-----FTDAGgVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQvqneytrryeGTGLGLSLV-KGLV 437
Cdd:cd16924 9 LVENAIQhglspLTDKG-VVTISALKEDNHVMIEVEDNGRGIDPKVLNILGKKPKE----------GNGIGLYNVhQRLI 77
|
90 100
....*....|....*....|....*.
gi 2105929845 438 ALHGGTFV--IASQPGEGTVVTIMLP 461
Cdd:cd16924 78 LLFGEDYGihIASEPDKGTRITFTIP 103
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-461 |
5.21e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.77 E-value: 5.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 367 NAIKFTDAGGV-VSIDAAREgkMLKLTVSDTGIGIASDkidllgqpfmqvqneytRRYEGTGLGLSLVKGLVALHGGTFV 445
Cdd:cd16917 11 NALKHAGASRVrVTLSYTAD--ELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERAELLGGTLT 71
|
90
....*....|....*.
gi 2105929845 446 IASQPGEGTVVTIMLP 461
Cdd:cd16917 72 IGSRPGGGTRVTARLP 87
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-461 |
7.94e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 42.41 E-value: 7.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 330 LQAKEKGLTLTSRIQRGIGEISADQR-AIRQVLINLAGNAIK--FTD-AGGVVSIDAAREGKMLKLTVSDTGIGIASDKI 405
Cdd:cd16951 12 INAIHAVGDIRINITGDTGPVSSEVAtAIGLVVNELLQNALKhaFSDrEGGTITIRSVVDGDYLRITVIDDGVGLPQDED 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2105929845 406 DLlgqpfmqvqneytrryEGTGLGLSLVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16951 92 WP----------------NKGSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
376-461 |
1.30e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 42.95 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 376 GVVSIDAAREGKMLKLTVSDTGIGIASDKI------------------------DLLGQPFMQVQNEYTRrYEGTGLGLS 431
Cdd:cd16916 70 GTITLRAEHQGNQVVIEVSDDGRGIDREKIrekaierglitadeaatlsddevlNLIFAPGFSTAEQVTD-VSGRGVGMD 148
|
90 100 110
....*....|....*....|....*....|
gi 2105929845 432 LVKGLVALHGGTFVIASQPGEGTVVTIMLP 461
Cdd:cd16916 149 VVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-461 |
1.61e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 40.88 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 367 NAIKF----TDAGGVVSIDAAREGKMLKLTVSDTGIGIA-SDKIDLLGQPfmqvqneytrryeGTGLGLSLV-KGLVALH 440
Cdd:cd16956 12 NAVKHglsgLLDGGRVEITARLDGQHLLLEVEDNGGGMDpDTLARILIRS-------------SNGLGLNLVdKRLRQAF 78
|
90 100
....*....|....*....|...
gi 2105929845 441 GGTF--VIASQPGEGTVVTIMLP 461
Cdd:cd16956 79 GNDYglDIECAPGEGTRITIRLP 101
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
353-458 |
4.10e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.28 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFT---DAGGVVSIDAAREGKMLKLTVSDTGIGIasdkidllgqPFMQVQNEYTRRYEGtGLG 429
Cdd:COG2172 31 DADDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGF----------DPEDLPDPYSTLAEG-GRG 99
|
90 100
....*....|....*....|....*....
gi 2105929845 430 LSLVKGLVAlhggTFVIASQPGeGTVVTI 458
Cdd:COG2172 100 LFLIRRLMD----EVEYESDPG-GTTVRL 123
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-460 |
7.27e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 39.92 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 353 DQRAIRQVLINLAGNAIKFTDagGVVSIDAAREGKMLKLTVSDTGIGIASDKIDLLGQPFMQVQneytRRYEGTGLGLSL 432
Cdd:cd16954 34 ERNDLMELLGNLLDNACKWCL--EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLD----EQRPGQGLGLAI 107
|
90 100
....*....|....*....|....*...
gi 2105929845 433 VKGLVALHGGTFVIASQPGEGTVVTIML 460
Cdd:cd16954 108 AKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
373-458 |
1.07e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 39.44 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105929845 373 DAGGVVSIDAAREGKMLKLTVSDTGIGIasDKIDLLGQPFMQVQNEYTRryegTGLGLSLVKGLValhgGTFVIASQPGE 452
Cdd:cd16942 58 DPNGIVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTTKPELER----SGMGFTIMENFM----DEVIVESEVNK 127
|
....*.
gi 2105929845 453 GTVVTI 458
Cdd:cd16942 128 GTTVYL 133
|
|
| |
