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Conserved domains on  [gi|2110921575|ref|WP_225842451|]
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MULTISPECIES: DUF2087 domain-containing protein [Streptomyces]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3860 super family cl47334
Uncharacterized conserved protein, DUF2087 family [Function unknown];
22-191 1.35e-08

Uncharacterized conserved protein, DUF2087 family [Function unknown];


The actual alignment was detected with superfamily member COG3860:

Pssm-ID: 443069 [Multi-domain]  Cd Length: 170  Bit Score: 52.18  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2110921575  22 ALSALSTGRRLGILSAVAELNAAAGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTREGASLTARPEALGDLAASLAEh 101
Cdd:COG3860     5 LLLLASESLLALAAALLLSAASASTAALLLFLLRLKAKAALLLLLAALLLAELLLARAAALAAPREAAAADARAAITEA- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2110921575 102 talnrivPPDSPLRRYL-SHGRITGLPKRPEDLEALALALAALLPEDRSLTENEVNTLLAQAGDDVARLRRLLADFALVD 180
Cdd:COG3860    84 -------EREKVLRRFFdEDGRLKRIPAKRKKRLVVLEHLASRFEPGRKYSEKEVNEILKRIHEDYATLRRELVDYGLLT 156

                         170
                  ....*....|..
gi 2110921575 181 R-AGSAEYRRRP 191
Cdd:COG3860   157 RtADGSVYWRIE 168
 
Name Accession Description Interval E-value
COG3860 COG3860
Uncharacterized conserved protein, DUF2087 family [Function unknown];
22-191 1.35e-08

Uncharacterized conserved protein, DUF2087 family [Function unknown];


Pssm-ID: 443069 [Multi-domain]  Cd Length: 170  Bit Score: 52.18  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2110921575  22 ALSALSTGRRLGILSAVAELNAAAGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTREGASLTARPEALGDLAASLAEh 101
Cdd:COG3860     5 LLLLASESLLALAAALLLSAASASTAALLLFLLRLKAKAALLLLLAALLLAELLLARAAALAAPREAAAADARAAITEA- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2110921575 102 talnrivPPDSPLRRYL-SHGRITGLPKRPEDLEALALALAALLPEDRSLTENEVNTLLAQAGDDVARLRRLLADFALVD 180
Cdd:COG3860    84 -------EREKVLRRFFdEDGRLKRIPAKRKKRLVVLEHLASRFEPGRKYSEKEVNEILKRIHEDYATLRRELVDYGLLT 156

                         170
                  ....*....|..
gi 2110921575 181 R-AGSAEYRRRP 191
Cdd:COG3860   157 RtADGSVYWRIE 168
DUF2087 pfam09860
Uncharacterized protein conserved in bacteria (DUF2087); This domain, found in various ...
 145-189 8.60e-06

Uncharacterized protein conserved in bacteria (DUF2087); This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids.


Pssm-ID: 462919  Cd Length: 67  Bit Score: 42.09  E-value: 8.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2110921575 145 PEDRSLTENEVNTLLAQAGDDVARLRRLLADFALVDR--AGSaEYRR 189
Cdd:pfam09860  22 EPGREYSEKEVNEILKAHHDDYATLRRELVDYGLLTRtrDGS-VYWR 67
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 19-80 4.16e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 4.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2110921575  19 AADALSALSTGRRLGILSAVAElnaaaGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTRE 80
Cdd:NF033788    1 LAELFKALADPTRLRILELLAE-----GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 23-80 5.64e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.58  E-value: 5.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2110921575  23 LSALSTGRRLGILSAVAElnaaaGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTRE 80
Cdd:cd00090     1 LKALSDPTRLRILRLLLE-----GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
COG3860 COG3860
Uncharacterized conserved protein, DUF2087 family [Function unknown];
22-191 1.35e-08

Uncharacterized conserved protein, DUF2087 family [Function unknown];


Pssm-ID: 443069 [Multi-domain]  Cd Length: 170  Bit Score: 52.18  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2110921575  22 ALSALSTGRRLGILSAVAELNAAAGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTREGASLTARPEALGDLAASLAEh 101
Cdd:COG3860     5 LLLLASESLLALAAALLLSAASASTAALLLFLLRLKAKAALLLLLAALLLAELLLARAAALAAPREAAAADARAAITEA- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2110921575 102 talnrivPPDSPLRRYL-SHGRITGLPKRPEDLEALALALAALLPEDRSLTENEVNTLLAQAGDDVARLRRLLADFALVD 180
Cdd:COG3860    84 -------EREKVLRRFFdEDGRLKRIPAKRKKRLVVLEHLASRFEPGRKYSEKEVNEILKRIHEDYATLRRELVDYGLLT 156

                         170
                  ....*....|..
gi 2110921575 181 R-AGSAEYRRRP 191
Cdd:COG3860   157 RtADGSVYWRIE 168
DUF2087 pfam09860
Uncharacterized protein conserved in bacteria (DUF2087); This domain, found in various ...
 145-189 8.60e-06

Uncharacterized protein conserved in bacteria (DUF2087); This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids.


Pssm-ID: 462919  Cd Length: 67  Bit Score: 42.09  E-value: 8.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2110921575 145 PEDRSLTENEVNTLLAQAGDDVARLRRLLADFALVDR--AGSaEYRR 189
Cdd:pfam09860  22 EPGREYSEKEVNEILKAHHDDYATLRRELVDYGLLTRtrDGS-VYWR 67
COG4190 COG4190
Predicted transcriptional regulator, contains HTH domain [Transcription];
20-93 2.07e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443344  Cd Length: 121  Bit Score: 42.19  E-value: 2.07e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2110921575  20 ADALSALSTGRRLGILSAVAElnaaAGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTREGASLTARPEALGD 93
Cdd:COG4190    43 PESLARVLTPKRLELLRAIAE----EGPESIRELARRLGRDVKNVHRDLKTLEELGLVELEEDGRAKRPVVPYD 112
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-101 6.42e-05

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 40.26  E-value: 6.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2110921575  11 ADSVTFSKAADALSALSTGRRLGILSAVAElnaaaGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVT--REGASL--TA 86
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAE-----GELCVGELAEALGLSQSTVSHHLKVLREAGLVTsrREGRWVyyRL 76

                          90
                  ....*....|....*
gi 2110921575  87 RPEALGDLAASLAEH 101
Cdd:COG0640    77 ADEALAELLEWLLEL 91
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
34-87 1.71e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 39.80  E-value: 1.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2110921575  34 ILSAVAELNAAAGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTRE---GASLTAR 87
Cdd:COG1321    11 YLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEpygGITLTEE 67
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 19-80 4.16e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 4.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2110921575  19 AADALSALSTGRRLGILSAVAElnaaaGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTRE 80
Cdd:NF033788    1 LAELFKALADPTRLRILELLAE-----GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 23-80 5.64e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.58  E-value: 5.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2110921575  23 LSALSTGRRLGILSAVAElnaaaGPARLADVAQKVGLDLKTLSKEVVRLTEAGLVTRE 80
Cdd:cd00090     1 LKALSDPTRLRILRLLLE-----GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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