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Conserved domains on  [gi|2119218104|ref|WP_226701680|]
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autorepressor SdpR family transcription factor [Priestia aryabhattai]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 5-82 1.27e-45

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


:

Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 140.63  E-value: 1.27e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLIQWFLIF 82
Cdd:NF033789   2 FKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 5-82 1.27e-45

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 140.63  E-value: 1.27e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLIQWFLIF 82
Cdd:NF033789   2 FKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
5-80 9.81e-30

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 100.73  E-value: 9.81e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLIQWFL 80
Cdd:COG0640   14 FKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLL 89
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-76 2.96e-28

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 96.76  E-value: 2.96e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2119218104  1 MNDKFKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLI 76
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-68 2.82e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 2.82e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSIN 68
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
16-80 1.09e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 1.09e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2119218104  16 ILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLIQWFL 80
Cdd:smart00418  2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 5-58 8.65e-15

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 62.17  E-value: 8.65e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2119218104  5 FKALADPTRRNILELLQKRD-LTAGEISSHFALTKPSVSNHLKILKQAEFIRSTR 58
Cdd:pfam12840  4 AEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 5-82 1.27e-45

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 140.63  E-value: 1.27e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLIQWFLIF 82
Cdd:NF033789   2 FKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
5-80 9.81e-30

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 100.73  E-value: 9.81e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLIQWFL 80
Cdd:COG0640   14 FKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLL 89
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-76 2.96e-28

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 96.76  E-value: 2.96e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2119218104  1 MNDKFKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLI 76
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-68 2.82e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 2.82e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSIN 68
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
16-80 1.09e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 1.09e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2119218104  16 ILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSVFEDLIQWFL 80
Cdd:smart00418  2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 5-58 8.65e-15

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 62.17  E-value: 8.65e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2119218104  5 FKALADPTRRNILELLQKRD-LTAGEISSHFALTKPSVSNHLKILKQAEFIRSTR 58
Cdd:pfam12840  4 AEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
5-58 1.15e-14

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 63.06  E-value: 1.15e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 2119218104  5 FKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTR 58
Cdd:COG4189   13 LKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEY 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 10-54 1.12e-13

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 58.99  E-value: 1.12e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 2119218104 10 DPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFI 54
Cdd:pfam01022  1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
3-79 6.42e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 58.89  E-value: 6.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119218104   3 DKFKALADPTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQ--------------FIIYSIN 68
Cdd:COG1777     9 RLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGRedgrarkyyrlsafRLEVTLT 88

                          90
                  ....*....|.
gi 2119218104  69 NSVFEDLIQWF 79
Cdd:COG1777    89 PDLFARLAREL 99
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
5-71 5.33e-10

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 52.19  E-value: 5.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2119218104   5 FKALADPTRRNIL-ELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYGQFIIYSINNSV 71
Cdd:COG3398    91 LAYLRRETPRRILlYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPE 158
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
1-58 9.11e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 49.54  E-value: 9.11e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2119218104   1 MND--KFKALADPTRRNILELLQKRD-LTAGEISSHFALTKPSVSNHLKILKQAEFIRSTR 58
Cdd:COG2345     1 MTDtpALAALADPTRRRILELLKRAGpVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
1-64 3.77e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 39.88  E-value: 3.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2119218104   1 MNDKFKALAD-----PTRRNILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRS-------TRYGQFII 64
Cdd:COG4742     1 MGSMKLDLLDflflsEKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIERddgeyelTTLGRLVV 76
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 16-58 1.71e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.03  E-value: 1.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 2119218104 16 ILELLQKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTR 58
Cdd:pfam12802 11 LLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
11-58 5.51e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.10  E-value: 5.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2119218104  11 PTRRNILELLQKRD-LTAGEISSHFALTKPSVSNHLKILKQAEFIRSTR 58
Cdd:COG1846    38 PAQFRVLAALAEAGgLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
11-60 3.31e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 34.02  E-value: 3.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2119218104  11 PTRRNILELL-----QKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTRYG 60
Cdd:COG1321     6 ESEEDYLKAIyelseEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYG 60
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
12-54 3.40e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 32.41  E-value: 3.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 2119218104 12 TRRNILELLQKR-DLTAGEISSHFALTKPSVSNHLKILKQAEFI 54
Cdd:pfam13412  2 TDRKILNLLQENpRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
10-60 6.45e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 33.21  E-value: 6.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2119218104  10 DPTRRNILELLQkRD--LTAGEISSHFALTKPSVSNHLKILKQAEFIRstRYG 60
Cdd:COG1522     4 DEIDRRILRLLQ-EDgrLSFAELAERVGLSESTVLRRVRRLEEAGVIR--GYG 53
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
16-58 6.47e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 32.57  E-value: 6.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2119218104   16 ILELL-QKRDLTAGEISSHFALTKPSVSNHLKILKQAEFIRSTR 58
Cdd:smart00347  15 VLRILyEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREP 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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