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Conserved domains on  [gi|2125356255|ref|WP_227257899|]
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MULTISPECIES: plasmid segregation protein ParM domain-containing protein, partial [Gammaproteobacteria]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 1-37 2.07e-12

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member pfam06406:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 317  Bit Score: 58.23  E-value: 2.07e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2125356255   1 MNIYCDDGSTNVKLAWFEGDELQTRVSANSFRHGWKV 37
Cdd:pfam06406   1 MKIFIDDGSTNIKLAWLEDGEVKTLISPNSFKPEWSV 37
 
Name Accession Description Interval E-value
StbA pfam06406
StbA protein; This family consists of several bacterial StbA plasmid stability proteins.
 1-37 2.07e-12

StbA protein; This family consists of several bacterial StbA plasmid stability proteins.


Pssm-ID: 310773 [Multi-domain]  Cd Length: 317  Bit Score: 58.23  E-value: 2.07e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2125356255   1 MNIYCDDGSTNVKLAWFEGDELQTRVSANSFRHGWKV 37
Cdd:pfam06406   1 MKIFIDDGSTNIKLAWLEDGEVKTLISPNSFKPEWSV 37
ASKHA_NBD_ParM_R1-like cd24022
nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and ...
 3-38 3.33e-08

nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and similar proteins from ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Escherichia coli ParM, also called ParA locus 36 kDa protein, or protein StbA. It is a plasmid-encoded protein involved in the control of plasmid partition and required for accurate segregation of low-copy-number plasmid R1.


Pssm-ID: 466872 [Multi-domain]  Cd Length: 324  Bit Score: 46.50  E-value: 3.33e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2125356255   3 IYCDDGSTNVKLAWFEGD-ELQTRVSANSFRHGWKVA 38
Cdd:cd24022     1 VGIDDGSANIKVAWGEDDgKIKTFKIPSRARRGAAVS 37
PRK13320 PRK13320
type III pantothenate kinase;
1-31 1.45e-03

type III pantothenate kinase;


Pssm-ID: 237348 [Multi-domain]  Cd Length: 244  Bit Score: 33.30  E-value: 1.45e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2125356255   1 MNIYCDDGSTNVKLAWFEGDELQ--TRVSANSF 31
Cdd:PRK13320    3 MNLVIDIGNTTTKLAVFEGDELLevFVVSTEGV 35
 
Name Accession Description Interval E-value
StbA pfam06406
StbA protein; This family consists of several bacterial StbA plasmid stability proteins.
 1-37 2.07e-12

StbA protein; This family consists of several bacterial StbA plasmid stability proteins.


Pssm-ID: 310773 [Multi-domain]  Cd Length: 317  Bit Score: 58.23  E-value: 2.07e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2125356255   1 MNIYCDDGSTNVKLAWFEGDELQTRVSANSFRHGWKV 37
Cdd:pfam06406   1 MKIFIDDGSTNIKLAWLEDGEVKTLISPNSFKPEWSV 37
ASKHA_NBD_ParM_R1-like cd24022
nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and ...
 3-38 3.33e-08

nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and similar proteins from ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Escherichia coli ParM, also called ParA locus 36 kDa protein, or protein StbA. It is a plasmid-encoded protein involved in the control of plasmid partition and required for accurate segregation of low-copy-number plasmid R1.


Pssm-ID: 466872 [Multi-domain]  Cd Length: 324  Bit Score: 46.50  E-value: 3.33e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2125356255   3 IYCDDGSTNVKLAWFEGD-ELQTRVSANSFRHGWKVA 38
Cdd:cd24022     1 VGIDDGSANIKVAWGEDDgKIKTFKIPSRARRGAAVS 37
PRK13320 PRK13320
type III pantothenate kinase;
1-31 1.45e-03

type III pantothenate kinase;


Pssm-ID: 237348 [Multi-domain]  Cd Length: 244  Bit Score: 33.30  E-value: 1.45e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2125356255   1 MNIYCDDGSTNVKLAWFEGDELQ--TRVSANSF 31
Cdd:PRK13320    3 MNLVIDIGNTTTKLAVFEGDELLevFVVSTEGV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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