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MULTISPECIES: GntR family transcriptional regulator [Streptomyces]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-238 1.20e-35

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 126.90  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739   8 TAPEPKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDS 86
Cdd:COG2188     1 SSPVPLYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  87 ----SDDQEWPGAADGEAWQAVDSEPAvpPAAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPELSAIDAP 162
Cdd:COG2188    81 ltsfTEELRARGREPSTRVLSAERVPA--DEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLE 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2125505739 163 SGPSRArvVLRELGRLGLEGQDRAVELGSARADDAKELDRLPGAPVLVVTTRFFSEGETAA-VSVATYRADTCRLTF 238
Cdd:COG2188   159 TGSLYE--LLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVeYSRSYYRGDRYRFVV 233
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-238 1.20e-35

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 126.90  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739   8 TAPEPKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDS 86
Cdd:COG2188     1 SSPVPLYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  87 ----SDDQEWPGAADGEAWQAVDSEPAvpPAAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPELSAIDAP 162
Cdd:COG2188    81 ltsfTEELRARGREPSTRVLSAERVPA--DEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLE 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2125505739 163 SGPSRArvVLRELGRLGLEGQDRAVELGSARADDAKELDRLPGAPVLVVTTRFFSEGETAA-VSVATYRADTCRLTF 238
Cdd:COG2188   159 TGSLYE--LLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVeYSRSYYRGDRYRFVV 233
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-76 5.93e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.17  E-value: 5.93e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2125505739  12 PKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVA 76
Cdd:cd07377     1 PLYEQIADQLREAILSgELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 23-237 8.44e-15

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 71.35  E-value: 8.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  23 EALDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDSSD-------DQEwpGA 95
Cdd:TIGR02325  20 EIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTrfsqnlaDQG--RE 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  96 ADGEAWQAVDsEPAVPpaAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPelsaiDAPSGPSRARVVLREL 175
Cdd:TIGR02325  98 PTGELLLSDL-EPASA--ELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFP-----GIGQAYAASGSITDAL 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2125505739 176 GRLGLEGQDRAVELGSARADDAKELDRL---PGAPVLVV-TTRFFSEGETAAVSVATYRADTCRLT 237
Cdd:TIGR02325 170 REQGVADYRRSSTRISARHADAKDCARLelpPGRPLLVVqALNHDGEGRPVQYSVSRFRADRVEFT 235
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
28-75 1.20e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.05  E-value: 1.20e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2125505739   28 EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTV 75
Cdd:smart00345  13 ELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 25-75 3.02e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 60.32  E-value: 3.02e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2125505739  25 LDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTV 75
Cdd:pfam00392  14 LSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 8-75 2.51e-10

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 59.02  E-value: 2.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2125505739   8 TAPEPKYWHLKTVLTEALDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTV 75
Cdd:PRK10079    8 TSYPTRYQEIAAKLEQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-238 1.20e-35

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 126.90  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739   8 TAPEPKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDS 86
Cdd:COG2188     1 SSPVPLYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  87 ----SDDQEWPGAADGEAWQAVDSEPAvpPAAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPELSAIDAP 162
Cdd:COG2188    81 ltsfTEELRARGREPSTRVLSAERVPA--DEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLE 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2125505739 163 SGPSRArvVLRELGRLGLEGQDRAVELGSARADDAKELDRLPGAPVLVVTTRFFSEGETAA-VSVATYRADTCRLTF 238
Cdd:COG2188   159 TGSLYE--LLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVeYSRSYYRGDRYRFVV 233
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-76 5.93e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.17  E-value: 5.93e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2125505739  12 PKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVA 76
Cdd:cd07377     1 PLYEQIADQLREAILSgELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 23-237 8.44e-15

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 71.35  E-value: 8.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  23 EALDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDSSD-------DQEwpGA 95
Cdd:TIGR02325  20 EIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTrfsqnlaDQG--RE 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  96 ADGEAWQAVDsEPAVPpaAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPelsaiDAPSGPSRARVVLREL 175
Cdd:TIGR02325  98 PTGELLLSDL-EPASA--ELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFP-----GIGQAYAASGSITDAL 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2125505739 176 GRLGLEGQDRAVELGSARADDAKELDRL---PGAPVLVV-TTRFFSEGETAAVSVATYRADTCRLT 237
Cdd:TIGR02325 170 REQGVADYRRSSTRISARHADAKDCARLelpPGRPLLVVqALNHDGEGRPVQYSVSRFRADRVEFT 235
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
25-86 1.09e-14

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 71.12  E-value: 1.09e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2125505739  25 LDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDS 86
Cdd:COG2186    21 LSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
28-75 1.20e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.05  E-value: 1.20e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2125505739   28 EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTV 75
Cdd:smart00345  13 ELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 25-75 3.02e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 60.32  E-value: 3.02e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2125505739  25 LDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTV 75
Cdd:pfam00392  14 LSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 8-75 2.51e-10

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 59.02  E-value: 2.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2125505739   8 TAPEPKYWHLKTVLTEALDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTV 75
Cdd:PRK10079    8 TSYPTRYQEIAAKLEQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 104-235 1.67e-09

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 54.99  E-value: 1.67e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  104 VDSEPAVPPAAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPELSAIDAPSGPSRarvVLRELGRLGLEGQ 183
Cdd:smart00866  11 LSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYE---YLEERLGLKIVRS 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2125505739  184 DRA---VELGSARADDAKELDRLPGAPVLVVT-TRFFSEGETAAVSVATYRADTCR 235
Cdd:smart00866  88 TRAeqtITAVLADEEEAELLGLPPGAPLLVVErVTYDDDGRPVEYSRSYYRGDRFR 143
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 8-79 1.58e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 54.45  E-value: 1.58e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2125505739   8 TAPEPKYWHLKTVLTEA-LDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPR 79
Cdd:COG1167     8 DSSGPLYLQLADALREAiLSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
8-77 2.58e-08

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 50.95  E-value: 2.58e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2125505739   8 TAPEPKYWHLKTVLTEA-LDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAP 77
Cdd:COG1725     6 DSGVPIYEQIADQIKEAiASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
PRK09764 PRK09764
GntR family transcriptional regulator;
9-80 5.69e-08

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 52.14  E-value: 5.69e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2125505739   9 APEPKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRV 80
Cdd:PRK09764    2 GHKPLYRQIADRIREQIARgELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERV 74
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
32-75 6.24e-08

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 51.95  E-value: 6.24e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2125505739  32 GEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTV 75
Cdd:PRK09464   31 GEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV 74
PRK11402 PRK11402
transcriptional regulator PhoB;
11-238 7.88e-08

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 51.76  E-value: 7.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  11 EPKYWHLKTVLTEALDSE-FAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVG---VAVDS 86
Cdd:PRK11402    8 QLLYATVRQRLLDDIAQGvYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEnalLTVSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739  87 SDDQewpGAADGEAWQA-VDSEPAVPPAAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPELSAIdaPSGP 165
Cdd:PRK11402   88 FTDF---GVSQGKATKEkVIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEI--YVEG 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2125505739 166 SRARVVLRELGRLGLEGQDRAVELGSARADDAKELDRLPGAPVLVVT-TRFFSEGETAAVSVATYRADtcRLTF 238
Cdd:PRK11402  163 SSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISkIAFDQNDKPVHVSELFCRAN--RVTL 234
PRK14999 PRK14999
histidine utilization repressor; Provisional
 1-79 1.09e-07

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 51.47  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739   1 MGTTQLETAPEPKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPR 79
Cdd:PRK14999    1 MYSSRSRSAPAPFYETVKQDICKKIAGgVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80
PRK10225 PRK10225
Uxu operon transcriptional regulator;
25-95 1.13e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 51.56  E-value: 1.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2125505739  25 LDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVapprvgvaVDSSDDQEWPGA 95
Cdd:PRK10225   23 IKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV--------LDSSGSHNTDSP 85
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 32-78 2.19e-07

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 50.54  E-value: 2.19e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2125505739  32 GEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPP 78
Cdd:PRK10421   23 GMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWR 69
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
25-78 3.97e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 49.54  E-value: 3.97e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2125505739  25 LDSEFAVGEILpNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPP 78
Cdd:COG1802    25 LSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL 77
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 104-232 4.07e-05

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 42.58  E-value: 4.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739 104 VDSEPAVPPAAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPELSAIDAPSGPSRArvVLRELGRLGLEGQ 183
Cdd:pfam07702  11 LSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYD--YLEERYGLPITRA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2125505739 184 DRAVELGSARADDAKELDRLPGAPVLVVTTRFFSEGETAA-VSVATYRAD 232
Cdd:pfam07702  89 EQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVeYSRSYYRGD 138
PRK11523 PRK11523
transcriptional regulator ExuR;
8-103 4.27e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 43.68  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125505739   8 TAPEPKYWHLKTVLTEALDS-EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDS 86
Cdd:PRK11523    4 TEPRRLYQQLAAELKERIEQgVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAA 83

                          90
                  ....*....|....*..
gi 2125505739  87 SDDQEWPGAADGEAWQA 103
Cdd:PRK11523   84 DNNMEFANYGPFELLQA 100
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 28-70 7.89e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 42.70  E-value: 7.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2125505739  28 EFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRG 70
Cdd:PRK03837   30 EFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG 72
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
29-65 3.04e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 41.01  E-value: 3.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2125505739  29 FAVGEILPNERDLAARFGVARATLRQALEQLELEGRL 65
Cdd:PRK04984   25 FPPGSILPAERELSELIGVTRTTLREVLQRLARDGWL 61
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 40-70 1.04e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 39.35  E-value: 1.04e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2125505739  40 DLAARFGVARATLRQALEQLELEGRLQRRRG 70
Cdd:COG1349    24 ELAERLGVSEETIRRDLAELEEQGLLRRVHG 54
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 25-77 4.58e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.44  E-value: 4.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2125505739  25 LDSEFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAP 77
Cdd:PRK09990   21 VDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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