|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
1-541 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1182.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 1 MPEFAYTDLLPQGEDTTPYRLVTTEGVSTAEGpDGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDPEASG 80
Cdd:PRK15389 2 MPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEF-EGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 81 NDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDEKNTG 160
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 161 SNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYA 240
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 241 LKTAKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSAD 320
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 321 RQAVAKITAEGVFLEQLETDPARFLPETTEETLSegdeaGDVVKIDLNQPMDDILAALTKYPVKTRLSLTGPLVVARDIA 400
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLE-----GEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIA 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 401 HAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNA 480
Cdd:PRK15389 396 HAKLKERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKK 475
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2125509725 481 HGGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFKD 541
Cdd:PRK15389 476 HGGFYLGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
40-340 |
2.01e-136 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 397.53 E-value: 2.01e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 40 KVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDpEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQN 119
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 120 VITEGGDEAALSRGIYDAYKNLNLRYSQMAPLnmwDEKNTGSNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYqetk 199
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPL---TRKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 200 aVLNEG----SMMKFLEEKIRSLGTAACPPYHLAIVVGGTsAEYALKTAKYASAHYLDEIPAEgselghgFRDKELEEKV 275
Cdd:COG1951 155 -MLNPSegleGVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2125509725 276 FELTQKIGIGAQ-FGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQAVAKITAEGVFleQLETD 340
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
331-541 |
3.06e-127 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 370.65 E-value: 3.06e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 331 GVFLEQLETDPARFLPETTEetlsegDEAGDVVKIDLNQPmdDILAALTKYPVKTRLSLTGPLVVARDIAHAKIKERLDA 410
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEE------DDLAEAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 411 GEEMPQYLKD--HPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNAHGGFYLGS 488
Cdd:pfam05683 73 GEPLPEYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGA 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2125509725 489 IGGpAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFKD 541
Cdd:pfam05683 153 IGG-AAYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
378-540 |
7.04e-70 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 221.93 E-value: 7.04e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 378 LTKYPVKTRLSLTGPLVVARDIAHAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYA-SGSFGPTTAGRMDSYVEQFQ 456
Cdd:TIGR00723 3 ILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPELL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 457 AAGGSKVMLAKGNRSQQVTDACNAHGGFYLGSIGGPAARLAQDcIKKVEVVEYEELGM-EAVWKIEVEDF-PAFVVVDDK 534
Cdd:TIGR00723 83 EKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQS-VKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAIDSH 161
|
....*.
gi 2125509725 535 GNDFFK 540
Cdd:TIGR00723 162 GNSIFQ 167
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
1-541 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1182.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 1 MPEFAYTDLLPQGEDTTPYRLVTTEGVSTAEGpDGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDPEASG 80
Cdd:PRK15389 2 MPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEF-EGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 81 NDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDEKNTG 160
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 161 SNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYA 240
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 241 LKTAKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSAD 320
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 321 RQAVAKITAEGVFLEQLETDPARFLPETTEETLSegdeaGDVVKIDLNQPMDDILAALTKYPVKTRLSLTGPLVVARDIA 400
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLE-----GEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIA 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 401 HAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNA 480
Cdd:PRK15389 396 HAKLKERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKK 475
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2125509725 481 HGGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFKD 541
Cdd:PRK15389 476 HGGFYLGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| PTZ00226 |
PTZ00226 |
fumarate hydratase; Provisional |
2-541 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 240319 [Multi-domain] Cd Length: 570 Bit Score: 1016.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 2 PEFAYTDLLP--QGEDTTPYRLVT--TEGVSTAE-GPDGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDP 76
Cdd:PTZ00226 27 PEFNFVPIFQpvDPHDTEEYRRLEdlSDYVEVVEvGGGGKEILKVPPEALTKLTSYAFSDIQHFLRKSHLAQLRRILDDP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 77 EASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDE 156
Cdd:PTZ00226 107 EASDNDRFVAMTLLKNACIAAGRVLPGCQDTGTAIVLGKRGELIWTGGEDEKALSKGVYNAYTNRNLRYSQLAPLDMFDE 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 157 KNTGSNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTS 236
Cdd:PTZ00226 187 KNTGCNLPAQIDLYATPGNEYEFLFIAKGGGSANKTFLYQQTKSLLNPKSLRKFLEEKIKTIGTSACPPYHLAVVIGGLS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 237 AEYALKTAKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVS 316
Cdd:PTZ00226 267 AEMTLKTVKLASCRYYDSLPTSGDEYGRAFRDLEWEEIILEKTQNIGIGAQFGGKYFAHDVRVIRLPRHGASCPIGIGVS 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 317 CSADRQAVAKITAEGVFLEQLETDPARFLPETTEETLSEGDEagdvVKIDLNQPMDDILAALTKYPVKTRLSLTGPLVVA 396
Cdd:PTZ00226 347 CSADRQILAKINKDGVYLEQLEHDPAQYLPDITEDDLSKTPV----VKIDLNQPMEEILKQLSKYPVKTRLSLTGTLIVA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 397 RDIAHAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTD 476
Cdd:PTZ00226 423 RDIAHAKIVEMLENGEPLPEYMKNHPIYYAGPAKTPDGYASGSFGPTTAGRMDSYVDLFMENGGSFITLAKGNRSKAVTN 502
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2125509725 477 ACNAHGGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFKD 541
Cdd:PTZ00226 503 ACKKYGGFYLGSIGGPAAILAKDNIKKVEVLDFPELGMEAVWKIEVENFPAFIVVDDKGNDFYSQ 567
|
|
| PLN00133 |
PLN00133 |
class I-fumerate hydratase; Provisional |
2-540 |
0e+00 |
|
class I-fumerate hydratase; Provisional
Pssm-ID: 215068 [Multi-domain] Cd Length: 576 Bit Score: 961.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 2 PEFAYTDLL-PQGEDTTPYRLVTTEGVSTAEGPdGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDPEASG 80
Cdd:PLN00133 39 PAFDYQPLFdSNAKKTVPWRKLTGDHVSVVEAA-GEKYLKVAPEALTLLSDTAMRDVAHLLRPGHLQQLRNILDDPEASD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 81 NDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDEKNTG 160
Cdd:PLN00133 118 NDRFVALELLKNANIAAGRVLPGCQDTGTAIVMGKRGQRVLTDGEDEEHLSRGVYDAYTDTNLRYSQVAPLDMFEEKNTG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 161 SNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYA 240
Cdd:PLN00133 198 TNLPAQIDLYAAKGDEYHFQFIAKGGGSANKTFLYQQTKALLNEGSLEAFLEEKIKTIGTSACPPYHLAIVIGGLSAEQN 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 241 LKTAKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSAD 320
Cdd:PLN00133 278 LKTVKLASTRYYDTLPTSGNALGRAFRDLEWEEKILKMTRGLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 321 RQAVAKITAEGVFLEQLETDPARFLPETTEETLSEgdeagDVVKIDLNQPMDDILAALTKYPVKTRLSLTGPLVVARDIA 400
Cdd:PLN00133 358 RQALGKITKDGVFLEALETDPSKYLPDVTEDSLSD-----DVVKVDLNRPMSEIRETLSAHPVRTRLSLTGTLVVARDIA 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 401 HAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNA 480
Cdd:PLN00133 433 HAKLLERLEAGEGLPQYAKDHIIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDRFMAAGGSFVTLAKGNRSAQVTNACKK 512
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 481 HGGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFK 540
Cdd:PLN00133 513 HGGFYLGSIGGPAAILAQNCIKKVEVLENPELGMEAVWKIEVEDFPAFIVVDDKGNDFFK 572
|
|
| PRK15391 |
PRK15391 |
class I fumarate hydratase; |
3-540 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185289 [Multi-domain] Cd Length: 548 Bit Score: 830.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 3 EFAYTDLLPQGEDTTPYRLVTTEGVSTAEGpDGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDPEASGND 82
Cdd:PRK15391 5 PFIYQAPFPMGKDNTEYYLLTSDYVSVADF-DGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASEND 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 83 KFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDEKNTGSN 162
Cdd:PRK15391 84 KYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEEALSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 163 LPAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYALK 242
Cdd:PRK15391 164 LPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 243 TAKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQ 322
Cdd:PRK15391 244 TVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRN 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 323 AVAKITAEGVFLEQLETDPARFLPETTEEtlsEGDeaGDVVKIDLNQPMDDILAALTKYPVKTRLSLTGPLVVARDIAHA 402
Cdd:PRK15391 324 IKAKINREGIWIEKLEHNPGQYIPQELRQ---AGE--GEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 403 KIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNAHG 482
Cdd:PRK15391 399 KLKELIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 2125509725 483 GFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFK 540
Cdd:PRK15391 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
|
|
| PRK15390 |
PRK15390 |
fumarate hydratase FumA; Provisional |
4-540 |
0e+00 |
|
fumarate hydratase FumA; Provisional
Pssm-ID: 185288 [Multi-domain] Cd Length: 548 Bit Score: 765.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 4 FAYTDLLPQGEDTTPYRLVTTEGVSTAEGpDGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDPEASGNDK 83
Cdd:PRK15390 6 FHYQAPFPLKKDDTEYYLLTSEHVSVSEF-EGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEASENDK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 84 FVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDEKNTGSNL 163
Cdd:PRK15390 85 YVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNTGTNL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 164 PAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYALKT 243
Cdd:PRK15390 165 PAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 244 AKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQA 323
Cdd:PRK15390 245 VKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNI 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 324 VAKITAEGVFLEQLETDPARFLPetteETLSEGDEaGDVVKIDLNQPMDDILAALTKYPVKTRLSLTGPLVVARDIAHAK 403
Cdd:PRK15390 325 KAKINRQGIWIEKLEHNPGKYIP----EELRKAGE-GEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 404 IKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNAHGG 483
Cdd:PRK15390 400 LKERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGG 479
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 2125509725 484 FYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFK 540
Cdd:PRK15390 480 FYLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
|
|
| PRK15392 |
PRK15392 |
class I fumarate hydratase; |
4-539 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185290 [Multi-domain] Cd Length: 550 Bit Score: 732.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 4 FAYTDLLPQGEDTTPYRLVTTEGVSTAEgPDGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDPEASGNDK 83
Cdd:PRK15392 5 FIWQEPFLQNKDGTEYTLISDQHITVTE-LDGEEVIKIAPEALTLLARQAFYEASFFLRSAHLQQVASILNDPQASSNDK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 84 FVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDEKNTGSNL 163
Cdd:PRK15392 84 YVALQLLRNAEVSAKGVLPNCQDTGTATIVASKGQQIWTGGNDAEALSKGIYSTFQENNLRFSQNAPLDMYTEVNTQTNL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 164 PAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYALKT 243
Cdd:PRK15392 164 PAQIDISAVAGDEYHFLCVNKGGGSANKAALYQETKSLLQPEKLTAFLIEKMKSLGTAACPPYHIAFVVGGLSADQTLKV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 244 AKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQA 323
Cdd:PRK15392 244 AKLASTKYYDNLPTSGNEQGQAFRDIELEKVLLEASQQFGIGAQFGGKYFAHDIRVIRLPRHGGSCPIAMALSCSADRNI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 324 VAKITAEGVFLEQLETDPARFLPETTEEtlsegDEAGDVVKIDLNQPMDDILAALTKYPVKTRLSLTGPLVVARDIAHAK 403
Cdd:PRK15392 324 KAKINKHGIWLEKLEHNPGQYIPASLRE-----ENHAQHVQLDLNRPLRDVMQDLARLPVGTRVSLSGPIVVARDIAHAK 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 404 IKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNAHGG 483
Cdd:PRK15392 399 IKARLDSGEPMPEYLKHHIVYYAGPAKTPENMACGSLGPTTGGRMDGYVDTFQAAGGSLVMLSKGNRSQQVTDACHKHGG 478
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 2125509725 484 FYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFF 539
Cdd:PRK15392 479 FNLGSIGGAAALLAQEYVKSLRCLEYPELGMEAVWMMEVENLPAFILVDDKGNNFF 534
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
40-340 |
2.01e-136 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 397.53 E-value: 2.01e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 40 KVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDpEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQN 119
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 120 VITEGGDEAALSRGIYDAYKNLNLRYSQMAPLnmwDEKNTGSNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYqetk 199
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPL---TRKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 200 aVLNEG----SMMKFLEEKIRSLGTAACPPYHLAIVVGGTsAEYALKTAKYASAHYLDEIPAEgselghgFRDKELEEKV 275
Cdd:COG1951 155 -MLNPSegleGVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2125509725 276 FELTQKIGIGAQ-FGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQAVAKITAEGVFleQLETD 340
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
331-541 |
3.06e-127 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 370.65 E-value: 3.06e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 331 GVFLEQLETDPARFLPETTEetlsegDEAGDVVKIDLNQPmdDILAALTKYPVKTRLSLTGPLVVARDIAHAKIKERLDA 410
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEE------DDLAEAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 411 GEEMPQYLKD--HPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNAHGGFYLGS 488
Cdd:pfam05683 73 GEPLPEYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGA 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2125509725 489 IGGpAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFKD 541
Cdd:pfam05683 153 IGG-AAYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| Fumerase |
pfam05681 |
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase ... |
48-323 |
4.44e-116 |
|
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.
Pssm-ID: 461713 Cd Length: 267 Bit Score: 344.78 E-value: 4.44e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 48 KLAEEAIHDIQHYLRPAHLAQLRRIIDDpEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGD- 126
Cdd:pfam05681 2 EAVAELIIEASTYLPPDVLEALKKALEK-EESPNAKFVLEQILENAEIAAEEKLPICQDTGMAVVFVKIGQDVHIEGGDl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 127 EAALSRGIYDAYKNLNLRYSQMAPLnmWDEKNTGSNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYqetkaVLNEG- 205
Cdd:pfam05681 81 EEAINEGVRRAYTEGPLRKSVVADP--LTRKNTGDNTPAVIHIEIVPGDELKITVAPKGGGSENMSALK-----MLNPAd 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 206 ---SMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYALKtAKYASahyLDEIPAEGSElghgFRDKELEEKVFELTQKI 282
Cdd:pfam05681 154 gleGVKKFVLETVKEAGPNACPPYIVGVGIGGTFEKAALL-AKKAL---LRPLGTRNPD----PRGAELEEELLEAINKL 225
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2125509725 283 GIGAQ-FGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQA 323
Cdd:pfam05681 226 GIGPQgLGGKTTALDVHIERAPTHIASLPVAVNVQCWADRHA 267
|
|
| FumA |
COG1838 |
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ... |
365-541 |
3.77e-98 |
|
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441443 Cd Length: 190 Bit Score: 295.86 E-value: 3.77e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 365 IDLNQPMDDIlaALTKYPVKTRLSLTGPLVVARDIAHAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTT 444
Cdd:COG1838 4 IRLNTPLTEE--DVRKLKAGDRVLLSGTIYTARDAAHKRLVELLDRGEPLPVDLKGQVIYYVGPAPAKPGYVIGSAGPTT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 445 AGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACNAHGGFYLGSIGGPAARLAQdCIKKVEVVEYEELGMEAVWKIEVED 524
Cdd:COG1838 82 STRMDKYTPELLEELGLKGMIGKGGRSPEVIEAMKKHGAVYLAAVGGAAALLAK-AIKKVEVVAYEDLGPEAIWKLEVED 160
|
170
....*....|....*..
gi 2125509725 525 FPAFVVVDDKGNDFFKD 541
Cdd:COG1838 161 FPLIVAIDSKGNSLYEQ 177
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
378-540 |
7.04e-70 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 221.93 E-value: 7.04e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 378 LTKYPVKTRLSLTGPLVVARDIAHAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYA-SGSFGPTTAGRMDSYVEQFQ 456
Cdd:TIGR00723 3 ILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPELL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 457 AAGGSKVMLAKGNRSQQVTDACNAHGGFYLGSIGGPAARLAQDcIKKVEVVEYEELGM-EAVWKIEVEDF-PAFVVVDDK 534
Cdd:TIGR00723 83 EKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQS-VKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAIDSH 161
|
....*.
gi 2125509725 535 GNDFFK 540
Cdd:TIGR00723 162 GNSIFQ 167
|
|
| PRK06842 |
PRK06842 |
Fe-S-containing hydro-lyase; |
389-540 |
7.40e-42 |
|
Fe-S-containing hydro-lyase;
Pssm-ID: 180724 [Multi-domain] Cd Length: 185 Bit Score: 148.78 E-value: 7.40e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 389 LTGPLVVARDIAHAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAgGSKVMLAKG 468
Cdd:PRK06842 25 ISGYIYTARDAAHKRLIELLDKGEELPIDIKDQIIYYVGPSPAKPGKVIGSAGPTTSYRMDAYAPRLLDI-GLKGMIGKG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2125509725 469 NRSQQVTDACNAHGGFYLGSIGGPAARLAQDcIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFK 540
Cdd:PRK06842 104 ARSDEVIESIKKNKAVYFGAIGGAAALIAKS-IKKSEVIAYEDLGAEAIRKLEVKDFPVVVIIDSEGNNLYE 174
|
|
| PRK06246 |
PRK06246 |
fumarate hydratase; Provisional |
44-327 |
1.28e-40 |
|
fumarate hydratase; Provisional
Pssm-ID: 180486 Cd Length: 280 Bit Score: 148.39 E-value: 1.28e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 44 EALRKLAEEAihdiQHYLRPAHLAQLRRIIDDpEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITE 123
Cdd:PRK06246 11 EAVAELCIEA----NYYLPDDVKEALKKAYEK-EESPIGKEILKAILENAEIAKEEQVPLCQDTGMAVVFVEIGQDVHIE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 124 GGD-EAALSRGIYDAYKNLNLRYSQMA-PLNmwdEKNTGSNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAV 201
Cdd:PRK06246 86 GGDlEDAINEGVRKGYEEGYLRKSVVAdPLT---RKNTGDNTPAVIHTEIVPGDKLKITVAPKGGGSENMSALKMLKPAD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 202 LNEGsMMKFLEEKIRSLGTAACPPYHLAIVVGGTsAEYALKTAKYASAHYLDEiPAEGSELghgfrdKELEEKVFELTQK 281
Cdd:PRK06246 163 GLEG-IKKFVLETVKEAGGNPCPPIIVGVGIGGT-FDKAAKLAKKALLRPIGE-RNPDPEI------AALEEELLEEINK 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2125509725 282 IGIGAQ-FGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQAVAKI 327
Cdd:PRK06246 234 LGIGPMgLGGKTTALDVKIETYPCHIASLPVAVNIQCHAARHAEVVL 280
|
|
| ttdA_fumA_fumB |
TIGR00722 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S ... |
75-327 |
7.86e-32 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase alpha chain and the N-terminal region of the class I fumarase (where the C-terminal region is homologous to the tartrate dehydratase beta chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 273234 Cd Length: 273 Bit Score: 124.11 E-value: 7.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 75 DPEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNLRYSQMAPLnmw 154
Cdd:TIGR00722 29 DREESEIAKINLEAILDNIEIAEKLGVPVCQDTGVPIFFVKVGSRFVLIGKLYEAIKQGVEEATEEVPLRPNAVHPL--- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 155 DEKNTGSNL---PAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGsMMKFLEEKIRSLGTAACPPyhlaIV 231
Cdd:TIGR00722 106 TRENTGDNTglgVPQIHVEIVPGDELEIVVFPKGAGSENPSALKMLKPSDGIEG-VKKFVLETVKNAGGKPCPP----II 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 232 VG---GTSAEYALKTAKYAsahYLDEIpaegSELGHGFRDKELEEKVFELTQKIGIGAQ-FGGKYFCHDVRVVRLPRHGA 307
Cdd:TIGR00722 181 VGvgiGGSFETAAKLAKKA---LLRPI----GERHPNPKIAKLELELLEEINSLGIGPMgLGGKTTALDVKIESAHCHTA 253
|
250 260
....*....|....*....|
gi 2125509725 308 SCPVAIAVSCSADRQAVAKI 327
Cdd:TIGR00722 254 SLPVAVNIQCWAHRRATLVV 273
|
|
| PRK06043 |
PRK06043 |
fumarate hydratase; Provisional |
389-540 |
1.32e-26 |
|
fumarate hydratase; Provisional
Pssm-ID: 180366 Cd Length: 192 Bit Score: 106.77 E-value: 1.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 389 LTGPLVVARDIAHAKIKERLDAGEEMPQYLKDHPVYYAGP--AKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLA 466
Cdd:PRK06043 25 ISGEILTARDEAHARILEMKEKGKELPFSLEGAVIYHCGPlmKKTDEGWKVVSAGPTTSARMSKMTPKLLEKVEVRAIIG 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2125509725 467 KGNRsQQVTDACNAhGGFYLGSIGGPAArLAQDCIKKVEVVEYEELGM-EAVWKIEVEDF-PAFVVVDDKGNDFFK 540
Cdd:PRK06043 105 KGGM-KNVADALKG-KCVYLAYTGGCAA-LAAESIKRVKAVHWLDLGMpEAVWVLEVEEFgPLIVGIDAKGNDLYS 177
|
|
| PRK08228 |
PRK08228 |
L(+)-tartrate dehydratase subunit beta; Validated |
389-541 |
2.14e-24 |
|
L(+)-tartrate dehydratase subunit beta; Validated
Pssm-ID: 236192 Cd Length: 204 Bit Score: 100.90 E-value: 2.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 389 LTGPLVVARDIAHAKIKERldaGEEMPQYLKDHPVYYAGP----AKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVM 464
Cdd:PRK08228 26 LTGTLVTCRDVAHRRLIEL---GRELPVDLNGGAIFHAGPivrpKKNDDKFEMVSVGPTTSMRMEKFEKEFIEQTGVKLI 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2125509725 465 LAKGNRSQQVTDACNAHGGFYLGSIGGPAArLAQDCIKKVEVVEYEELGM-EAVWKIEVEDF-PAFVVVDDKGNDFFKD 541
Cdd:PRK08228 103 VGKGGMGPGTEEGCQEFKALHCVFPAGCAV-LAATQVEEIEDAQWRDLGMpETLWVCRVKEFgPLIVSIDTHGNNLFEE 180
|
|
| PRK08395 |
PRK08395 |
fumarate hydratase; Provisional |
371-540 |
6.82e-16 |
|
fumarate hydratase; Provisional
Pssm-ID: 169425 Cd Length: 162 Bit Score: 75.23 E-value: 6.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 371 MDDILaaltKYPVKTRLSLTGPLVVARDIAHAKIKErldagEEMPQYLKDHPVYYAGPAKTPEGYASGsfGPTTAGRMDS 450
Cdd:PRK08395 9 WEDVL----KLKAGDVVYLSGIIYTARDLAHRRFLS-----EGFPFNPEGAVIYHCGPLVKNKKIVSA--GPTTSARMNK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 451 YVEqFQAAGGSKVMLAKGNRSqqvtdacnaHGGF-----YLGSIGGpAARLAQDCIKKVEVVEYEELGM-EAVWKIEVED 524
Cdd:PRK08395 78 YLD-FLFSLGVRGIIGKGGMN---------AEPFkgravYFAFPGG-AGSLAAKSIKRVRDVYWEDLGMpDAVWELEVED 146
|
170
....*....|....*.
gi 2125509725 525 FPAFVVVDDKGNDFFK 540
Cdd:PRK08395 147 FPLLVAIDSKGRSLYR 162
|
|
| PRK08230 |
PRK08230 |
tartrate dehydratase subunit alpha; Validated |
64-330 |
3.36e-14 |
|
tartrate dehydratase subunit alpha; Validated
Pssm-ID: 181309 Cd Length: 299 Bit Score: 73.59 E-value: 3.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 64 AHLAQLRRIIDDPEAsgndKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVITEGGDEAALSRGIYDAYKNLNL 143
Cdd:PRK08230 31 AKLKELKDAETSPLA----KIIYDTMFENQQLAIDLNRPSCQDTGVIQFFVKVGARFPLLGELESILKEAVEEATVKAPL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 144 RYSQMAPlnmWDEKNTGSNLPAQI-----ELYATDGGAYKFLIMAKGG----GSANksflyqetkaVLNEGS----MMKF 210
Cdd:PRK08230 107 RHNAVET---FDEYNTGKNTGSGVpwvfwEIVPDSDDAEIEVYMAGGGctlpGRAK----------VLMPGEgyegVVKF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125509725 211 LEEKIRSLGTAACPPyhLAIVVG-GTSAEYALKTAKYASAHYLdeipaeGSELGHGfRDKELEEKVFELTQKIGIGAQ-F 288
Cdd:PRK08230 174 VFDVITSYGVNACPP--LLVGVGiATSVETAAVLSKKAILRPI------GSRNPNP-RAAELEKRLEEGLNRIGLGPQgL 244
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2125509725 289 GGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQAVAKITAE 330
Cdd:PRK08230 245 TGNSSVMGVNIESAARHPSTIGVAVSTGCWAHRRGTIVFDAD 286
|
|
| |
