|
Name |
Accession |
Description |
Interval |
E-value |
| his_kin_PieS |
NF041210 |
two component system sensor histidine kinase PieS; |
2-462 |
4.31e-127 |
|
two component system sensor histidine kinase PieS;
Pssm-ID: 469114 [Multi-domain] Cd Length: 474 Bit Score: 377.21 E-value: 4.31e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 2 KYFYQQlvgFLSVVLVSVIVC---GLLFYNVMTNKIFLQRSQQLFGYAKAILV-------HDLTADEINSSLSLLKDEHL 71
Cdd:NF041210 4 KYQYQL---FLTQFIILLIAClmiGLLISHFLKDYFFESQVNDLTKYGVTISRdikymsdEDQTVPVLNTYQRILDVKNI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 72 GVAIFDKNNKMTYPATA--LNVKSTLTDDELQHLQDGSAINMKqAKHNFVGEaadLVTIYYPIFKNQTYNGFLAISSPLS 149
Cdd:NF041210 81 HYTILNNNNQIIYPNNNrpLPPDFKISDADMKKLEKGETVSIK-VDNRFNQE---MSVVYVPILNGDEFLGSIILNSPIS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 150 HIETEMAELRNSILVGFSSAAVVGVILSVLFANYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESL 229
Cdd:NF041210 157 GTEKVIGTINQYMFYTILLSITIALILSAILSKLQVNRINKLRKATKRVIRGNYETRLKENNFDEIGALAHDFNKMTETL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 230 QKSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKIRSDQ 309
Cdd:NF041210 237 AESKEEIERQEKRRRQFIADVSHEMRTPLTTISGLTEGLVNDIIPKSETDRCIALIDTEAKRLTKLVNENLDYERIRSNK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 310 IVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEDFTVYADYDRFIQILVNMTKNANQFTDKGHILIKGWNEETKA 389
Cdd:NF041210 317 IQLYKTRFGVHAFLDLIKEQLEPLASEKGNQIIVDAPLDLEVYADYDRLTQIVINIVKNSIQFTENGTITLTGRQDYKET 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2128734729 390 IVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:NF041210 397 ILTITDTGIGMDTGELEQIWERFYKADMSRTSTAFGESGIGLSIVKQLVEYHDGSIEVESEPNKGTTFTIRLP 469
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
151-466 |
1.89e-69 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 225.97 E-value: 1.89e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 151 IETEMAELRNSILVGFSSAAVVGVILSVLFANYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQ 230
Cdd:COG5002 73 LLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 231 KSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMI-PESRRERSLELITNETQRLIRLVNENLDYEKIRSDQ 309
Cdd:COG5002 153 RDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAAdDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 310 IVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPED-FTVYADYDRFIQILVNMTKNANQFTDKG-HILIKGWNEET 387
Cdd:COG5002 233 LKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGDPDRLEQVLTNLLDNAIKYTPEGgTITVSLREEDD 312
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2128734729 388 KAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFPGKEE 466
Cdd:COG5002 313 QVRISVRDTGIGIPEEDLPRIFERFYRVDKSR-SRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
229-462 |
2.66e-62 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 202.44 E-value: 2.66e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 229 LQKSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHM-IPESRRERSLELITNETQRLIRLVNENLDYEKIRS 307
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 308 DQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPED-FTVYADYDRFIQILVNMTKNANQFT-DKGHILIKGWNE 385
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSpPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2128734729 386 ETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKntkYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG---EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
139-462 |
3.49e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 197.44 E-value: 3.49e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 139 NGFLAISSPLSHIETEMAELRNSILVGFSSAAVVGVILSVLFANYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDL 218
Cdd:COG0642 6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 219 VMDFNKMAESLQKSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRerSLELITNETQRLIRLVNE 298
Cdd:COG0642 86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQRE--YLETILRSADRLLRLIND 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 299 NLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEDF-TVYADYDRFIQILVNMTKNANQFTDKG- 376
Cdd:COG0642 164 LLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGg 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 377 HILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKntkYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTT 456
Cdd:COG0642 244 TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR---GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTT 320
|
....*.
gi 2128734729 457 FTLTFP 462
Cdd:COG0642 321 FTVTLP 326
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
156-468 |
4.61e-44 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 159.74 E-value: 4.61e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 156 AELRNSILVGFSSAAVVGVILSV----LFANYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQK 231
Cdd:COG5000 1 SGLQILFLLLLLLIALLLLLLALwlalLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 232 SEQEIARQENL--------------------------------------------------------------------- 242
Cdd:COG5000 81 QREELEERRRYletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeei 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 243 ------RRQLMMD----------------------------------VAHEMRTPLTTMNGLLEGLIHHM---IPESRR- 278
Cdd:COG5000 161 eltrdgRRTLLVRasplrddgyvivfdditellraerlaawgelarrIAHEIKNPLTPIQLSAERLRRKLadkLEEDREd 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 279 -ERSLELITNETQRLIRLVNENLDYEKIRSdqivLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEDF-TVYADYD 356
Cdd:COG5000 241 lERALDTIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 357 RFIQILVNMTKNANQFT-DKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKvdvsrknTKYGESGIGLAIVH 435
Cdd:COG5000 317 QLEQVLINLLKNAIEAIeEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFT-------TKPKGTGLGLAIVK 389
|
410 420 430
....*....|....*....|....*....|...
gi 2128734729 436 SLMKSHHGTIQTESEVGKGTTFTLTFPGKEETE 468
Cdd:COG5000 390 KIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
162-462 |
4.07e-38 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 144.39 E-value: 4.07e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 162 ILVGFSS--AAVVGVILSV-LFANyqtrrINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQKSEQeiar 238
Cdd:PRK10549 168 LIVALSTllAALATFLLARgLLAP-----VKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQ---- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 239 qenLRRQLMMDVAHEMRTPLTTMNGLLEGL---IHHMIPEsrrerSLELITNETQRLIRLVNE----------NLDYEKI 305
Cdd:PRK10549 239 ---MRRDFMADISHELRTPLAVLRGELEAIqdgVRKFTPE-----SVASLQAEVGTLTKLVDDlhqlslsdegALAYRKT 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 306 RSDQIVLvkqnfsganaLQNVVDQLQELAVNKGNELRCECPEDFTVYADYDRFIQILVNMTKNANQFTDK-GHILIKGWN 384
Cdd:PRK10549 311 PVDLVPL----------LEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSgGSLHISAEQ 380
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2128734729 385 EETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRkNTKYGESGIGLAIVHSLMKSHHGTIQTE-SEVGkGTTFTLTFP 462
Cdd:PRK10549 381 RDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSR-NRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELP 457
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
155-462 |
1.14e-35 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 137.52 E-value: 1.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 155 MAELRNSILVgfssAAVVGVILSVLFANYQTRR----INRLRKATHEIAEGNYDISL-PTQKRDEFDDLVMDFNKMaesL 229
Cdd:TIGR01386 159 LDALRKWLIL----IAVLLVLLTALLGWWITRLglepLRRLSAVAARISPESLDQRLdPSRAPAELRELAQSFNAM---L 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 230 QKSEQEIARQEnlrrQLMMDVAHEMRTPLTTmngllegLIHHMIPESRRERSLE-----LITN--ETQRLIRLVNENLDY 302
Cdd:TIGR01386 232 GRLEDAFQRLS----QFSADLAHELRTPLTN-------LLGQTQVALSQPRTGEeyrevLESNleELERLSRMVSDMLFL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 303 EKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCEcpEDFTVYADYDRFIQILVNMTKNANQFT-DKGHILIK 381
Cdd:TIGR01386 301 ARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVE--GEGLVRGDPQMFRRAISNLLSNALRHTpDGGTITVR 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 382 GWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKYGeSGIGLAIVHSLMKSHHGTIQTESEVGKgTTFTLTF 461
Cdd:TIGR01386 379 IERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEG-TGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRF 456
|
.
gi 2128734729 462 P 462
Cdd:TIGR01386 457 P 457
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
224-466 |
4.08e-35 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 136.03 E-value: 4.08e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 224 KMAESLQKSEQEIARQ-ENLRRQLMMDVAHEMRTPLTTMNGLLEgLIHHMIPESRRERSLELITNETQRLIRLVNENLDY 302
Cdd:COG5808 221 KRKTLLERVIQEINTQkLELIGTFAASTAHEIRNPLTSIKGFIQ-LLQEKYPELEDQKYFDIIQEEIQRINQIVSEFLVL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 303 EKIRSDQIVLVKQNfsgaNALQNVVDQLQELAVNKGNELRCECPED-FTVYADYDRFIQILVNMTKNANQFT-DKGHILI 380
Cdd:COG5808 300 GKPTAKKLELDDLN----ELIEEILSIIDSEANLKNIRVEKQSLDEpLHIKCDKDRIKQVLLNLIKNAIEAMkEGGKLTI 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 381 KGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLT 460
Cdd:COG5808 376 SIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFV-------TTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIR 448
|
....*.
gi 2128734729 461 FPGKEE 466
Cdd:COG5808 449 LPLKKE 454
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
231-462 |
8.88e-34 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 130.29 E-value: 8.88e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 231 KSEQEIARQENLR--RQLMMDVAHEMRTPLTTMNGLLEgLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKIRsd 308
Cdd:COG5807 133 EAEDKLLRSEKLSvaGELAAGIAHEIRNPLTSIKGFLQ-LLQESREDSEREEYFNIIISEIDRINTIITELLVLSKPK-- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 309 qivlvKQNFSGAN---ALQNVVDQLQELAVNKGNELRCECPEDFT-VYADYDRFIQILVNMTKNANQ-FTDKGHILIKGW 383
Cdd:COG5807 210 -----KFNFKKLNlndVLEDVIALLSTEAILKNISIKYDLADDEPvINGDKNQLKQVFINLIKNAIEaMETGGNITIKTY 284
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2128734729 384 NEETKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:COG5807 285 VEGDFVVISVKDEGIGIPEEVLEKIGEPFF-------TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
163-468 |
5.35e-33 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 128.04 E-value: 5.35e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 163 LVGFSSAAVVGVILSVLFANYQT--RRINRLRKATHEIAEGNYDISLPTQKR-------------DEFDDLVMDFNKMAE 227
Cdd:COG3852 39 LLGLSAEELLGRPLAELFPEDSPlrELLERALAEGQPVTEREVTLRRKDGEErpvdvsvsplrdaEGEGGVLLVLRDITE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 228 sLQKSEQEIARQENLR--RQLMMDVAHEMRTPLTTMNGLLEgLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKI 305
Cdd:COG3852 119 -RKRLERELRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQ-LLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 306 RSDQIVLVkqnfsganALQNVVDQLQELA---VNKGNELRCECPEDF-TVYADYDRFIQILVNMTKNANQ-FTDKGHILI 380
Cdd:COG3852 197 RPPEREPV--------NLHEVLERVLELLraeAPKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEaMPEGGTITI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 381 KGWNEETKAI----------VQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESE 450
Cdd:COG3852 269 RTRVERQVTLgglrprlyvrIEVIDNGPGIPEEILDRIFEPFF-------TTKEKGTGLGLAIVQKIVEQHGGTIEVESE 341
|
330
....*....|....*...
gi 2128734729 451 VGKGTTFTLTFPGKEETE 468
Cdd:COG3852 342 PGKGTTFRIYLPLEQAEE 359
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
121-462 |
4.57e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 122.98 E-value: 4.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 121 EAADLVTIYYPIFKNQTYNGFLAISSPLSHIETEMAELRNSILVGFSSAAVVGVILSVLFANYQTRRINRLRKATHEIAE 200
Cdd:COG4191 4 LLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 201 GNYDISLPTQKRDEFDDLVMDFNKMAESLQKS----EQEIARQENLRRQLMMD------------VAHEMRTPLTTMNGL 264
Cdd:COG4191 84 LLLLLLLEALLLLLLAALDAEENAELEELERDitelERAEEELRELQEQLVQSeklaalgelaagIAHEINNPLAAILGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 265 LEGLIHHMIPESRRE---RSLELITNETQRLIRLVNENLDYekirSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNEL 341
Cdd:COG4191 164 AELLRRRLEDEPDPEelrEALERILEGAERAAEIVRSLRAF----SRRDEEEREPVDLNELIDEALELLRPRLKARGIEV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 342 RCECPED-FTVYADYDRFIQILVNMTKNANQ-FTDK--GHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYkvdv 417
Cdd:COG4191 240 ELDLPPDlPPVLGDPGQLEQVLLNLLINAIDaMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF---- 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2128734729 418 SRKNTKYGeSGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:COG4191 316 TTKPVGKG-TGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
231-466 |
6.84e-30 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 122.77 E-value: 6.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 231 KSEQEIARQENLRR--QLMMDVAHEMRTPLTTMNGLLEgLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKIRSD 308
Cdd:PRK11360 376 RLQRRVARQERLAAlgELVAGVAHEIRNPLTAIRGYVQ-IWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRES 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 309 QIVLVKQNFsganALQNVVDQLQELAVNKGNELRCECPEDF-TVYADYDRFIQILVNMTKNANQ-FTDKGHILIKGWNE- 385
Cdd:PRK11360 455 QWQPVSLNA----LVEEVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQaISARGKIRIRTWQYs 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 386 ETKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFPGKE 465
Cdd:PRK11360 531 DGQVAVSIEDNGCGIDPELLKKIFDPFF-------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
.
gi 2128734729 466 E 466
Cdd:PRK11360 604 Q 604
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
231-462 |
1.13e-29 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 120.85 E-value: 1.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 231 KSEQEIARQENLRR--QLMMDVAHEMRTPLTTMNG---LLEGLIHhmipeSRRERSLELITNETQRLIRLVNENLDYEKI 305
Cdd:COG5809 256 KLEELLRKSEKLSVvgELAAGIAHEIRNPLTSLKGfiqLLKDTID-----EEQKTYLDIMLSELDRIESIISEFLVLAKP 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 306 RSDQIVLVkqNFSGAnaLQNVVDQLQELAVNKGNELRCECPEDFT-VYADYDRFIQILVNMTKNANQFTDK-GHILIK-G 382
Cdd:COG5809 331 QAIKYEPK--DLNTL--IEEVIPLLQPQALLKNVQIELELEDDIPdILGDENQLKQVFINLLKNAIEAMPEgGNITIEtK 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 383 WNEETKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:COG5809 407 AEDDDKVVISVTDEGCGIPEERLKKLGEPFY-------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
142-462 |
1.46e-29 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 120.65 E-value: 1.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 142 LAISSPLSHIETEMAELrnsilvgFSSAAVVG--VILSVLFANYQTRR-INRLRKATHEIAEGNYDISL-PTQKRDEFDD 217
Cdd:PRK09835 171 LSIDFHLHYINDLKNKL-------IMTASVISllIVFIVLLAVHKGHApIRSVSRQIQNITSKDLDVRLdPQTVPIELEQ 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 218 LVMDFNKMaesLQKSEQEIARQENLRrqlmMDVAHEMRTPLTtmNGLLEGLIhhMIPESRRERSLE--LITN--ETQRLI 293
Cdd:PRK09835 244 LVLSFNHM---IERIEDVFTRQSNFS----ADIAHEIRTPIT--NLITQTEI--ALSQSRSQKELEdvLYSNleELTRMA 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 294 RLVNENLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEdFTVYADYDRFIQILVNMTKNANQFT 373
Cdd:PRK09835 313 KMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDP-CQVAGDPLMLRRAISNLLSNALRYT 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 374 DKGHILIKGWNEETKAIVQIIDD-GIGIHEKEVEAIWERFYKVDVSRKNTKYGeSGIGLAIVHSLMKSHHGTIQTESEVg 452
Cdd:PRK09835 392 PAGEAITVRCQEVDHQVQLVVENpGTPIAPEHLPRLFDRFYRVDPSRQRKGEG-SGIGLAIVKSIVVAHKGTVAVTSDA- 469
|
330
....*....|
gi 2128734729 453 KGTTFTLTFP 462
Cdd:PRK09835 470 RGTRFVISLP 479
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
207-462 |
2.05e-29 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 122.06 E-value: 2.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 207 LPTQKRDEFDDLVMDFNKMAESLQKS-------------EQEIARQE----NLRRQL-MMDVAHEMRTPLTTMNGLLEGL 268
Cdd:PRK15347 344 LPENRLDELGSIAKAYNQLLDTLNEQydtlenkvaertqALAEAKQRaeqaNKRKSEhLTTISHEIRTPLNGVLGALELL 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 269 IH-HMIPESRRerSLELITNETQRLIRLVNENLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPE 347
Cdd:PRK15347 424 QNtPLTAEQMD--LADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGA 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 348 DFTVYADYD--RFIQILVNMTKNANQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTkyg 425
Cdd:PRK15347 502 HVPLYLHLDslRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGT--- 578
|
250 260 270
....*....|....*....|....*....|....*..
gi 2128734729 426 esGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:PRK15347 579 --GLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
227-464 |
8.41e-29 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 117.28 E-value: 8.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 227 ESLQKSE---QEIARQENLR--RQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNENLD 301
Cdd:COG5806 180 ENLIENIllrKELQRAEKLEvvSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLT 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 302 YEKIRSDQIvlvkQNFSGANALQNVVDQLQELAVNKGNELRCECPEDFTVYADYDRFIQILVNMTKNA-NQFTDKGHILI 380
Cdd:COG5806 260 FAKPQPEKL----EKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGiEAMPNGGTLTI 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 381 KGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLT 460
Cdd:COG5806 336 DVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF-------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTIT 408
|
....
gi 2128734729 461 FPGK 464
Cdd:COG5806 409 LPLA 412
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
353-462 |
4.93e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 107.35 E-value: 4.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 353 ADYDRFIQILVNMTKNANQFTDK-GHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDvsRKNTKYGESGIGL 431
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD--KRSRKIGGTGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 2128734729 432 AIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:smart00387 79 SIVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
86-466 |
4.54e-27 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 113.73 E-value: 4.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 86 ATALNVKSTLTDDELQHLQDGSAINMKQAKHNFVGEAADLVTIYYPIFKNQTYNGFLAISSPLSHIETEMAELRNSILVG 165
Cdd:COG4251 125 LLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLR 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 166 FSSAAVVGVILSVLFANYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQKSEQEIARQENLRRQ 245
Cdd:COG4251 205 LLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 246 LMMDVAHEMRTPLTTMNG----LLEGLIHHMIPESRRerSLELITNETQRLIRLVNENLDYekIRSDQIVLVKQNFSGAN 321
Cdd:COG4251 285 FAYVASHDLREPLRKISGfsqlLEEDYGDKLDEEGRE--YLERIRDAAERMQALIDDLLAY--SRVGRQELEFEPVDLNE 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 322 ALQNVVDQLQELAVNKGNELRCEcpEDFTVYADYDRFIQILVNMTKNANQFTDKG---HILIKGWNEETKAIVQIIDDGI 398
Cdd:COG4251 361 LLEEVLEDLEPRIEERGAEIEVG--PLPTVRGDPTLLRQVFQNLISNAIKYSRPGeppRIEIGAEREGGEWVFSVRDNGI 438
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2128734729 399 GIHEKEVEAIWERFYKVDvsrKNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFPGKEE 466
Cdd:COG4251 439 GIDPEYAEKIFEIFQRLH---SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
358-462 |
2.41e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 102.57 E-value: 2.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 358 FIQILVNMTKNANQFTDKGHILIKGW-----NEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRkNTKYGESGIGLA 432
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSST-TRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 2128734729 433 IVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
240-462 |
2.50e-26 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 110.49 E-value: 2.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 240 ENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKIRSdqivlvkqnfSG 319
Cdd:PRK11006 201 EGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEA----------AP 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 320 ANALQNVVD------QLQELAV---NKGNELRCECPEDFTVYADYDRFIQILVNMTKNANQFTDKG-HILIKGWNEETKA 389
Cdd:PRK11006 271 TIDLNEKVDvpmmlrVLEREAQtlsQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGtHITVRWQRVPQGA 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2128734729 390 IVQIIDDGIGIHEKEVEAIWERFYKVDVSR-KNTkyGESGIGLAIV-HSLmkSHHGT-IQTESEVGKGTTFTLTFP 462
Cdd:PRK11006 351 EFSVEDNGPGIAPEHIPRLTERFYRVDKARsRQT--GGSGLGLAIVkHAL--SHHDSrLEIESEVGKGTRFSFVLP 422
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
131-462 |
3.65e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 110.70 E-value: 3.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 131 PIFKNQTYNGFLAISSPLS----HIETEMAELRNSILVGFSSAAVVGVILSVLFanyqTRRINRLRKATHEIAEGNyDIS 206
Cdd:PRK11100 153 PIRDGGRIIGVLSVGKPNSsmapFIKRSERRILWAGALLLGIALLIGAGVVWWL----NRSIRRLTRYADAVTEGK-PVP 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 207 LPTQKRDEFDDLvmdfnkmAESLqkseqeiarqENLRRQL---------MMDVAHEMRTPLTTMNGLLEGLIHHMiPESR 277
Cdd:PRK11100 228 LPKLGSSELREL-------AQAL----------ESMRVKLegkayveqyVQTLTHELKSPLAAIRGAAELLQEDP-PPED 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 278 RERSLELITNETQRLIRLVNENLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCEcPEDFTVYADYDR 357
Cdd:PRK11100 290 RARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLR-PDDARVLGDPFL 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 358 FIQILVNMTKNANQFT-DKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVdvSRKNTKYGESGIGLAIVHS 436
Cdd:PRK11100 369 LRQALGNLLDNAIDFSpEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSL--PRPANGRKSTGLGLAFVRE 446
|
330 340
....*....|....*....|....*.
gi 2128734729 437 LMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:PRK11100 447 VARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
358-461 |
9.12e-25 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 98.06 E-value: 9.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 358 FIQILVNMTKNANQFTDK-GHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRkntKYGESGIGLAIVHS 436
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPgGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSR---EGGGTGLGLAIVRR 77
|
90 100
....*....|....*....|....*
gi 2128734729 437 LMKSHHGTIQTESEVGKGTTFTLTF 461
Cdd:cd00075 78 IVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
117-466 |
1.23e-24 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 105.87 E-value: 1.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 117 NFVGEAADLVTIYYPIFKNQTYNGFLAISSPLSHIETEMAELRNSILVGFSSAAVVGVILSVLFANYQTRRINRLRKATH 196
Cdd:COG2972 114 LLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMK 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 197 EIAEGNYdISLPTQKRDEFDDLVMDFNKMAESLQKSEQEIARQENLRRQLMMDvAHEMR-TP---LTTMNGlleglIHHM 272
Cdd:COG2972 194 KVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELK-ALQAQiNPhflFNTLNS-----IRWL 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 273 IPESRRERSLELITNetqrLIRLVNENLDyekiRSDQIVLVKQNFsgaNALQNVVDqLQELAVNKGNELRCECPEDFTVY 352
Cdd:COG2972 267 AELEDPEEAEEMLEA----LSKLLRYSLS----KGDELVTLEEEL---ELIKSYLE-IQKLRFGDRLEVEIEIDEELLDL 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 353 ADYDRFIQILVNmtkNA-----NQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFykvdvsrkNTKYGES 427
Cdd:COG2972 335 LIPKLILQPLVE---NAiehgiEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL--------SSKGEGR 403
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2128734729 428 GIGLAIVHSLMKSHHG---TIQTESEVGKGTTFTLTFPGKEE 466
Cdd:COG2972 404 GIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
243-462 |
4.38e-24 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 105.97 E-value: 4.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 243 RRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKIRSDQIVLVKQNFSGANA 322
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 323 LQNVVDQLQELAVNKGNELRCEC--PEDFTVYADYDRFIQILVNMTKNANQFTDKGHILIKG---WNEETKAIVQ--IID 395
Cdd:PRK09959 792 VQNTCHSFGAIAASKSIALSCSStfPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTslgHIDDNHAVIKmtIMD 871
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2128734729 396 DGIGIHEKEVEAIWERFYKVDVSRKNTKygeSGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:PRK09959 872 SGSGLSQEEQQQLFKRYSQTSAGRQQTG---SGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
231-462 |
4.72e-24 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 104.81 E-value: 4.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 231 KSEQEIARQENLR--RQLMMDVAHEMRTPLTTMNGLLEGLIHHMIpesRRERSLELITNETQRLIRLVNENLDYEKIRSD 308
Cdd:COG5805 273 EAEELMARSEKLSiaGQLAAGIAHEIRNPLTSIKGFLQLLQPGIE---DKEEYFDIMLSELDRIESIISEFLALAKPQAV 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 309 QivlvKQNFSGANALQNVVDQLQELAVNKGNELRCEC-PEDFTVYADYDRFIQILVNMTKNA-NQFTDKGHILIKGWNEE 386
Cdd:COG5805 350 N----KEKENINELIQDVVTLLETEAILHNIQIRLELlDEDPFIYCDENQIKQVFINLIKNAiEAMPNGGTITIHTEEED 425
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2128734729 387 TKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:COG5805 426 NSVIIRVIDEGIGIPEERLKKLGEPFF-------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
222-462 |
5.65e-24 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 104.10 E-value: 5.65e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 222 FNKMAESLQKSEQEIARQENLRR--QLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNEN 299
Cdd:PRK10364 214 YRRYLRSRQLLQDEMKRKEKLVAlgHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSEL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 300 LdyEKIRSDQIVLVKQNFsgaNALQNVVDQLQEL-AVNKGNELRCECPEDF-TVYADYDRFIQILVNMTKNANQFTDK-G 376
Cdd:PRK10364 294 L--ELVKPTHLALQAVDL---NDLINHSLQLVSQdANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQhG 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 377 HILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTT 456
Cdd:PRK10364 369 VISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF-------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGAT 441
|
....*.
gi 2128734729 457 FTLTFP 462
Cdd:PRK10364 442 FTLWLP 447
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
226-462 |
1.22e-23 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 101.95 E-value: 1.22e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 226 AESLQKSEQEIA-RQEN--LRRQL--------MmdVAHEMRTPLTTMNGLLEGLIHHMIPESR------RERSLELITNE 288
Cdd:PRK09303 125 QELLQLSDELFVlRQENetLLEQLkfkdrvlaM--LAHDLRTPLTAASLALETLELGQIDEDTelkpalIEQLQDQARRQ 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 289 TQRLIRLVNENLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEDF-TVYADYDRFIQILVNMTK 367
Cdd:PRK09303 203 LEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLD 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 368 NANQFT-DKGHILIKGWNEETKAI-VQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKYGesgIGLAIVHSLMKSHHGTI 445
Cdd:PRK09303 283 NAIKYTpEGGTITLSMLHRTTQKVqVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYG---IGLSVCRRIVRVHYGQI 359
|
250
....*....|....*..
gi 2128734729 446 QTESEVGKGTTFTLTFP 462
Cdd:PRK09303 360 WVDSEPGQGSCFHFTLP 376
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
353-462 |
5.45e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 93.20 E-value: 5.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 353 ADYDRFIQILVNMTKNANQFTDK-GHILIKGWNEETkAIVQIIDDGIGIHEKEVEAIWERFYKVDvsrkNTKYGESGIGL 431
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKaGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTAD----KRGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|.
gi 2128734729 432 AIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
162-462 |
2.18e-22 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 98.14 E-value: 2.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 162 ILVGFssaaVVGVILSVLFANYQTRRINRLRKATHEIAEGnyDISLPTQKRD----EFDDLVMDFNKMAESLQKSEQEiA 237
Cdd:NF012226 66 ILCGS----VISLIIGMKLAQRFIVPINFLADAAKKISQG--DLSARAEDSQihsaEISELMHNFNDMAQKLESSVKN-A 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 238 RQENlrrqlmMDVAHEMRTPLTTMNGLLEGLIHHM-IPESRRERSL----ELITN--ETQRLIRLVnEN----LDYEKIR 306
Cdd:NF012226 139 QVWN------AAIAHELRTPITILQGRLQGILDGVfEPDPALFKSLlnqvEGLSHlvEDLRTLSLV-ENqqlrLNYESVD 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 307 SDQIVlvkqnfsganalQNVVDQLQELAVNKGNELRCECPEDFtVYADYDRFIQILVNMTKNANQFTDKGHILIKGWNEE 386
Cdd:NF012226 212 LKDSI------------EKVLKMFEDRLEQAQLTIVLNLTATP-VFCDRRRIEQVLIALIDNAIRYANAGKLKISSSVIQ 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2128734729 387 TKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGkGTTFTLTFP 462
Cdd:NF012226 279 DDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSR-NKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQG-NSVFTIKLP 352
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
190-462 |
7.39e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 94.67 E-value: 7.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 190 RLRKATHEIAEGNYD--ISLPtqKRDEFDDLVMDFNKMAESLQkseQEIARqenlRRQLMMDVAHEMRTPLTTMnglleg 267
Cdd:PRK10604 166 KLEAAAQRLGDGHLAerIHFD--EGSSLERLGVAFNQMADNIN---ALIAS----KKQLIDGIAHELRTPLVRL------ 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 268 lihhmipESRRERSLELITNETQRLIR-------LVNENLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQelAVNKGNE 340
Cdd:PRK10604 231 -------RYRLEMSDNLSAAESQALNRdigqleaLIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQ--AVTPEKT 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 341 LRCECP--EDFtVYADYDRFIQILVNMTKNANQFTDkGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVS 418
Cdd:PRK10604 302 VRLDTPhqGDY-GALDMRLMERVLDNLLNNALRYAH-SRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPS 379
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2128734729 419 RkNTKYGESGIGLAIVHSLMKSHHGTIQ-TESEVGkGTTFTLTFP 462
Cdd:PRK10604 380 R-DRATGGCGLGLAIVHSIALAMGGSVNcDESELG-GARFSFSWP 422
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-462 |
3.48e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 85.33 E-value: 3.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 364 NMTKNANQFT-DKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKYGeSGIGLAIVHSLMKSHH 442
Cdd:cd16952 7 NLVSNAVKYTpPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGG-TGLGLAIVKHVMSRHD 85
|
90 100
....*....|....*....|
gi 2128734729 443 GTIQTESEVGKGTTFTLTFP 462
Cdd:cd16952 86 ARLLIASELGKGSRFTCLFP 105
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
73-462 |
6.66e-19 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 89.91 E-value: 6.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 73 VAIFDKNNK-------------MTYPATalnvKSTLTDDELQHLQDgsainmkqakhnfvgeaadLVTIYYPIFKNQTYN 139
Cdd:PRK11107 86 IAVFDENNQlfvtsnyhldfesMRLPEG----LPIPRLLSVERDGD-------------------SLILRTPIISESYSP 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 140 GFLAISS------PLSHIETEMAelRNSILVG-----FSSAAVV--GVILSVLFAnYQ-----TRRINRLRKATHEIAEG 201
Cdd:PRK11107 143 DESASSDaknsqnMLGYIAIELD--LKSVRLQqyreiFIAFLMLllGIGLALLFA-FRlmrdvTGPIRNMVNTVDRIRRG 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 202 NYDISLPTQKRDEFDDLVMDFNKMAESLqkSEQEIARQEN-------LRRQL--M------MDVA--------------- 251
Cdd:PRK11107 220 QLDSRVEGNMLGELDMLKNGINAMAMSL--SAYHEEMQQNidqatsdLRETLeqMeiqnveLDLAkkraqeaariksefl 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 252 ----HEMRTPLttmNG-------LLEGLIHhmipESRR------ERSlelITNetqrLIRLVNENLDYEKIRSDQIVLVK 314
Cdd:PRK11107 298 anmsHELRTPL---NGvigftrqTLKTPLT----PTQRdylqtiERS---ANN----LLAIINDILDFSKLEAGKLVLEN 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 315 QNFSGANALQNVVDQLQELAVNKGNEL----RCECPEDFTvyADYDRFIQILVNMTKNANQFTDKGHILIKgwnEETKAI 390
Cdd:PRK11107 364 IPFSLRETLDEVVTLLAHSAHEKGLELtlniDPDVPDNVI--GDPLRLQQIITNLVGNAIKFTESGNIDIL---VELRAL 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 391 --------VQIIDDGIGIHEKEVEAIWERFYKVD--VSRKntkYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLT 460
Cdd:PRK11107 439 sntkvqleVQIRDTGIGISERQQSQLFQAFRQADasISRR---HGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFH 515
|
..
gi 2128734729 461 FP 462
Cdd:PRK11107 516 LP 517
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
227-468 |
9.95e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 89.32 E-value: 9.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 227 ESLQKSEQ-EIAR----QENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPE-SRRERSLELITNETQRLIRLVNENL 300
Cdd:PRK10490 643 ERLTLTASeEQARlaseREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEgSPHARQASEIRQQVLNTTRLVNNLL 722
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 301 DYEKIRSDQIVLVKQnfsgANALQNVV-DQLQELAVN-KGNELRCECPEDFT-VYADYDRFIQILVNMTKNANQFT-DKG 376
Cdd:PRK10490 723 DMARIQSGGFNLRKE----WLTLEEVVgSALQMLEPGlSGHPINLSLPEPLTlIHVDGPLFERVLINLLENAVKYAgAQA 798
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 377 HILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFykvdvSRKNTkygES-----GIGLAIVHSLMKSHHGTIQTESEV 451
Cdd:PRK10490 799 EIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF-----ARGNK---ESaipgvGLGLAICRAIVEVHGGTIWAENRP 870
|
250
....*....|....*..
gi 2128734729 452 GKGTTFTLTFPGKEETE 468
Cdd:PRK10490 871 EGGACFRVTLPLETPPE 887
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
250-462 |
1.13e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 89.19 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 250 VAHEMRTPLTTMNGLLEGLIHHMIPESRRErSLELITNETQRLIRLVNENLDYEKIR--SDQIVLVKQNFSGA----NAL 323
Cdd:PRK11466 451 MSHEIRTPLYGILGTAQLLADNPALNAQRD-DLRAITDSGESLLTILNDILDYSAIEagGKNVSVSDEPFEPRplleSTL 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 324 QNVVDQLQELAVNKGNELRCECPEdfTVYADYDRFIQILVNMTKNANQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEK 403
Cdd:PRK11466 530 QLMSGRVKGRPIRLATDIADDLPT--ALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPA 607
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2128734729 404 EVEAIWERFYKVDVSRkntkyGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:PRK11466 608 KLAEIFQPFVQVSGKR-----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
224-462 |
1.34e-18 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 88.88 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 224 KMAESLQKSEQEiARQENLRRQLMM-DVAHEMRTPLTTMNGLLEGLIHHMIPESRrERSLELITNETQRLIRLVNENLDY 302
Cdd:PRK10841 428 KMEESLQEMAQA-AEQASQSKSMFLaTVSHELRTPLYGIIGNLDLLQTKELPKGV-DRLVTAMNNSSSLLLKIISDILDF 505
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 303 EKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEDFTVYADYD--RFIQILVNMTKNANQFTDKGHILI 380
Cdd:PRK10841 506 SKIESEQLKIEPREFSPREVINHITANYLPLVVKKRLGLYCFIEPDVPVALNGDpmRLQQVISNLLSNAIKFTDTGCIVL 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 381 KGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDvSRKNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLT 460
Cdd:PRK10841 586 HVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVG-TGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIR 664
|
..
gi 2128734729 461 FP 462
Cdd:PRK10841 665 IP 666
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-462 |
1.35e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 78.27 E-value: 1.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 354 DYDRFIQILVNMTKNANQFTDKGHIL-IKGwnEETKAIVQII--DDGIGIHEKEVEAIWERFYKVDVSRkNTKYGESGIG 430
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLrIRA--AQTPQEVRLDveDSAPGVSDDQLARLFERFYRVESSR-NRASGGSGLG 77
|
90 100 110
....*....|....*....|....*....|...
gi 2128734729 431 LAIVHSLMKSHHGTIQTE-SEVGkGTTFTLTFP 462
Cdd:cd16946 78 LAICHNIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
250-462 |
2.00e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 84.99 E-value: 2.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 250 VAHEMRTPLttmNGLLeGLihhmipeSRRERSLELitNETQR------------LIRLVNENLDYEKIRSDQIVLVKQ-- 315
Cdd:PRK11091 290 ISHELRTPL---NGIV-GL-------SRILLDTEL--TAEQRkylktihvsaitLGNIFNDIIDMDKMERRKLQLDNQpi 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 316 NFSG-ANALQNVVDQLQElavNKGNELRCECPEDF--TVYADYDRFIQILVNMTKNANQFTDKGHILIKGWNEETKAIV- 391
Cdd:PRK11091 357 DFTDfLADLENLSGLQAE---QKGLRFDLEPLLPLphKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTf 433
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2128734729 392 QIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:PRK11091 434 EVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
188-462 |
4.29e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 83.44 E-value: 4.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 188 INRLRKATHEIAEGNYDI--SLPTQKRdEFDDLVMDFNKMAESLqksEQEIARQEnlrrQLMMDVAHEMRTPLTTMNgLL 265
Cdd:PRK09470 194 ARKLKNAADEVAQGNLRQhpELETGPQ-EFRQAGASFNQMVTAL---ERMMTSQQ----RLLSDISHELRTPLTRLQ-LA 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 266 EGLIHHMIPESRrerSLELITNETQRLIRLVNENLDYEKIRSDQiVLVKQNFSgANAL-QNVVDQLQELAVNKGNELRCE 344
Cdd:PRK09470 265 TALLRRRQGESK---ELERIETEAQRLDSMINDLLVLSRNQQKN-HLERETFK-ANSLwSEVLEDAKFEAEQMGKSLTVS 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 345 C-PEDFTVYADYDRFIQILVNMTKNANQFTdKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTK 423
Cdd:PRK09470 340 ApPGPWPINGNPNALASALENIVRNALRYS-HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRES 418
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2128734729 424 yGESGIGLAIVHSLMKSHHGTIQTE-SEVGkGTTFTLTFP 462
Cdd:PRK09470 419 -GGTGLGLAIVENAIQQHRGWVKAEdSPLG-GLRLTIWLP 456
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
7.39e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 75.92 E-value: 7.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 360 QILVNMTKNANQFTD-KGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTkygesGIGLAIVHSLM 438
Cdd:cd16943 6 QVLLNLLVNAAQAMEgRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGT-----GLGLSLSYRII 80
|
90 100
....*....|....*....|....
gi 2128734729 439 KSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILP 104
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
144-445 |
3.06e-16 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 80.72 E-value: 3.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 144 ISSPLSHI-ETEMAEL-RNSILVGfssaavvgvILSV----LFANYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDD 217
Cdd:PRK09467 140 VRVPLTEIhQGDFSPLfRYTLAIG---------LLSVaggwLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRS 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 218 LVMDFNKMAESLQKSEQEiarqenlRRQLMMDVAHEMRTPLTTMNgllegLIHHMIPEsrrERSL--ELITNETQRLIRL 295
Cdd:PRK09467 211 VTRAFNQMAAGIKQLEDD-------RTLLMAGVSHDLRTPLTRIR-----LATEMMSE---EDGYlaESINKDIEECNAI 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 296 VNENLDYekIRSDQivlvKQNFSGA--NALqnvvdqLQELAVNKGNELR------CECPEDFTVYAdydrfIQI---LVN 364
Cdd:PRK09467 276 IEQFIDY--LRTGQ----EMPMEMAdlNAL------LGEVIAAESGYEReietalQPGPIEVPMNP-----IAIkraLAN 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 365 MTKNANQFTdKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKygeSGIGLAIVHSLMKSHHGT 444
Cdd:PRK09467 339 LVVNAARYG-NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSG---TGLGLAIVKRIVDQHNGK 414
|
.
gi 2128734729 445 I 445
Cdd:PRK09467 415 V 415
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
150-448 |
3.54e-16 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 79.63 E-value: 3.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 150 HIETEMAELRNSILVgfssAAVVGVILSVLFANYQTRRINR-LRKATHEIAEGNYDISLPTQKR---DEFDDLVMDFNKM 225
Cdd:PRK10755 51 HVMKEIREAVASLLV----PSLVMVSLTLLICFQAVRWITRpLAELQKELEARTADNLTPIAIHsstLEIEAVTSALNQL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 226 AESLQKSEQeiarQEnlrRQLMMDVAHEMRTPLTtmnglleGLIHHmipesrrersLELI----TNETQRLIrlvnENLD 301
Cdd:PRK10755 127 VSRLTSTLD----QE---RLFTADVAHELRTPLA-------GIRLH----------LELLekqhHIDVAPLI----ARLD 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 302 YEKIRSDQIVL---VKQNFSGANA-----LQNVV----DQLQELAVNKGNELR-CECPEDFTVYADYDRFIQILVNMTKN 368
Cdd:PRK10755 179 QMMHTVEQLLQlarAGQSFSSGHYqtvklLEDVIlpsqDELSEMLEQRQQTLLlPESAADITVQGDATLLRLLLRNLVEN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 369 ANQFTDKG-HILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDvsrknTKYGESGIGLAIVHSLMKSHHGTIQT 447
Cdd:PRK10755 259 AHRYSPEGsTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD-----SRYGGIGLGLSIVSRITQLHHGQFFL 333
|
.
gi 2128734729 448 E 448
Cdd:PRK10755 334 Q 334
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
116-466 |
3.84e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 76.81 E-value: 3.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 116 HNFVGEAADLVTIYYPIFKNQTYNGFLAISSPLSHIETEMAELRNSILVGFSSAAVvGVIL-----SVLFANYQTRRINR 190
Cdd:COG3290 40 LLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIRE-GVIAvdrdgRITLINDAARRLLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 191 LRKATHEIAEGNYDIsLPTQKRDE---FDDLVMDFNKMAESL------------QKSEQEIARQE---------NLRRQl 246
Cdd:COG3290 119 LDAIGRPIDEVLAEV-LETGERDEeilLNGRVLVVNRVPIRDdgrvvgavatfrDRTELERLEEElegvkelaeALRAQ- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 247 mmdvAHEMRTPLTTMNGLLEgLIHHmipesrrERSLELITNETQRLIRLvnenLDYEKIRSDQIVLvkqnfsgANALQNV 326
Cdd:COG3290 197 ----RHDFRNHLHTISGLLQ-LGEY-------DEALEYIDEISEELQEL----IDSLLSRIGNPVL-------AALLLGK 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 327 VDQLQELAVnkgnELRCECPEDFTVY--ADYDrFIQILVNMTKNA-----NQFTDKGHILIKGWNEETKAIVQIIDDGIG 399
Cdd:COG3290 254 AARARERGI----DLTIDIDSDLPDLplSDTD-LVTILGNLLDNAieaveKLPEEERRVELSIRDDGDELVIEVEDSGPG 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2128734729 400 IHEKEVEAIWERfykvDVSrknTKYGE-SGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFPGKEE 466
Cdd:COG3290 329 IPEELLEKIFER----GFS---TKLGEgRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-462 |
1.66e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 69.24 E-value: 1.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 357 RFI--QILVNMTKNANQftdKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKygESGIGLAIV 434
Cdd:cd16948 7 SFIigQIVSNALKYSKQ---GGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE--STGMGLYLV 81
|
90 100
....*....|....*....|....*...
gi 2128734729 435 HSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16948 82 KKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
48-468 |
5.62e-14 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 74.38 E-value: 5.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 48 AILVHDLTADEINSSLSLLKDEHLGVAIFDKNNKMTYPATALNVKSTLTDDELQHLQDGSAINMKQAKHNFVGEAADLVT 127
Cdd:COG2770 101 ALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLA 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 128 IYYPIFKNQTYNGFLAISSPLSHIETEMAELRNSILVGFSsAAVVGVILSVLFANYQTRRINRLRKATHEIAEGNYDISL 207
Cdd:COG2770 181 AAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALL-ALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRI 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 208 PTQKRDEFDDLVMDFNKMAESLQKSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITN 287
Cdd:COG2770 260 PVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLA 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 288 ETQRLIRLVNENLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEDFTVYADYDRFIQILVNMTK 367
Cdd:COG2770 340 LLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLAL 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 368 NANQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKYGESGIGLAIVHSLMKSHHGTIQT 447
Cdd:COG2770 420 ALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAG 499
|
410 420
....*....|....*....|.
gi 2128734729 448 ESEVGKGTTFTLTFPGKEETE 468
Cdd:COG2770 500 AAAEELAEELLLLEGLLLLLL 520
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
168-462 |
5.74e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 74.34 E-value: 5.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 168 SAAVVGVILSVLFANYQ-----TRRINRLRKATHEIAEGNYDISLPTQKRDEFDDL---VMDF-NKMAESLQKSEQEI-- 236
Cdd:COG4192 330 AIALLSLLLAVLINYFYvrrrlVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIarlLRVFrDQAIEKTQELETEIee 409
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 237 --ARQENLRR---------------QLMMDVAHEMRTPLTTMNGLLEGLIHHMIPES--RRERSLELITNETQRLIRLVN 297
Cdd:COG4192 410 rkRIEKNLRQtqdeliqaakmavvgQTMTSLAHELNQPLNAMSMYLFSAKKALEQENyaQLPTSLDKIEGLIERMDKIIK 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 298 eNLDYEKIRSD---QIVLVKQNFSGANALQNVVDQLQELAVNkgnelrceCPEDFTVYADYDRFIQILVNMTKNA-NQFT 373
Cdd:COG4192 490 -SLRQFSRKSDtplQPVDLRQVIEQAWELVESRAKPQQITLH--------IPDDLMVQGDQVLLEQVLVNLLVNAlDAVA 560
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 374 DKGHILIKGWNEETKAIVQIIDDGIGIheKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGK 453
Cdd:COG4192 561 TQPQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFT-------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLER 631
|
....*....
gi 2128734729 454 GTTFTLTFP 462
Cdd:COG4192 632 GAMVILEFN 640
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
43-468 |
1.68e-13 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 72.22 E-value: 1.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 43 FGYAKAILVHDLTADEINSSLSLLKDEHLGVAIFDKNNKMTYPATALNVKSTLTDDELQHLQDGSAINMKQAKHNFVGEA 122
Cdd:COG3850 1 LRELLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 123 ADLVTIYYPIFKNQTYNGFLAISSPLSHIETEMAELRNSILVGFSSAAVVGVILSVLFANYQTRRINRLRKATHEIAEGN 202
Cdd:COG3850 81 LLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 203 YDISLPTQKRDEFDDLVMDFNKMAESLQKSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHmipESRRERSL 282
Cdd:COG3850 161 FDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLAL---LLAALLAA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 283 ELITNETQRLIRLVNENLDYEKIRSDQIVLVKQNFSGANALQNVVDQLQELAVNKGNELRCECPEDFTVYADYDRFIQIL 362
Cdd:COG3850 238 LLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 363 VNMTKNANQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKYGESGIGLAIVHSLMKSHH 442
Cdd:COG3850 318 LLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAA 397
|
410 420
....*....|....*....|....*.
gi 2128734729 443 GTIQTESEVGKGTTFTLTFPGKEETE 468
Cdd:COG3850 398 GQGAGLVDVEGGVAGEGGLVVLIVSI 423
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
240-304 |
3.32e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 64.16 E-value: 3.32e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2128734729 240 ENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEK 304
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
5.94e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 65.04 E-value: 5.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 360 QILVNMTKNANQFTDKG-----HILIKGWNEETKAIVQiiDDGIGIHEKEVEAIWERFYKVDvSRKntKYGESGIGLAIV 434
Cdd:cd16921 3 QVLTNLLGNAIKFRRPRrppriEVGAEDVGEEWTFYVR--DNGIGIDPEYAEKVFGIFQRLH-SRE--EYEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 2128734729 435 HSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-461 |
7.53e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 64.73 E-value: 7.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 347 EDFTVYADYDRFIQILVNMTKNANQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDvsrkNTKYGE 426
Cdd:cd16940 3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSD----GQNYGG 78
|
90 100 110
....*....|....*....|....*....|....*
gi 2128734729 427 SGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTF 461
Cdd:cd16940 79 SGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
185-229 |
5.76e-12 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 60.15 E-value: 5.76e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2128734729 185 TRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESL 229
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-460 |
9.66e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.15 E-value: 9.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 347 EDFTVYA--DYDRFIQILVNMTKNANQFTDKGHIL-IKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTK 423
Cdd:cd16947 8 PDRPIYAnaNTEALQRILKNLISNAIKYGSDGKFLgMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAK 87
|
90 100 110
....*....|....*....|....*....|....*..
gi 2128734729 424 YGeSGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLT 460
Cdd:cd16947 88 QG-NGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVT 123
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
243-307 |
1.40e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.53 E-value: 1.40e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2128734729 243 RRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRErSLELITNETQRLIRLVNENLDYEKIRS 307
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQRE-YLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-462 |
1.44e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 60.80 E-value: 1.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 364 NMTKNANQFTDkGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRkNTKYGESGIGLAIVHSLMKSHHG 443
Cdd:cd16949 7 NVLRNALRYSP-SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSAR-DRESGGTGLGLAIAERAIEQHGG 84
|
90
....*....|....*....
gi 2128734729 444 TIQTESEVGKGTTFTLTFP 462
Cdd:cd16949 85 KIKASNRKPGGLRVRIWLP 103
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
227-462 |
2.67e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 64.72 E-value: 2.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 227 ESLQKSEQEIARQenLRRQLmmdvAHEMRTPLTTMNGLLEgLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKir 306
Cdd:PRK11073 120 EQLQHAQQVAARD--LVRGL----AHEIKNPLGGLRGAAQ-LLSKALPDPALTEYTKVIIEQADRLRNLVDRLLGPQR-- 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 307 sdqivlvkqnfSGANALQNV------VDQLQELavnkgnelrcECPEDFTVYADYDRFI-----------QILVNMTKNA 369
Cdd:PRK11073 191 -----------PGTHVTESIhkvaerVVQLVSL----------ELPDNVRLIRDYDPSLpelahdpdqieQVLLNIVRNA 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 370 NQFTDKGH------------ILIKGWNEETKAIVQIIDDGIGIHEKEVEAIwerFYKVdVSRKNtkyGESGIGLAIVHSL 437
Cdd:PRK11073 250 LQALGPEGgtitlrtrtafqLTLHGERYRLAARIDIEDNGPGIPPHLQDTL---FYPM-VSGRE---GGTGLGLSIARNL 322
|
250 260
....*....|....*....|....*
gi 2128734729 438 MKSHHGTIQTESEVGKgTTFTLTFP 462
Cdd:PRK11073 323 IDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
243-307 |
7.44e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.58 E-value: 7.44e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2128734729 243 RRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRErSLELITNETQRLIRLVNENLDYEKIRS 307
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQRE-YLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HAMP |
pfam00672 |
HAMP domain; |
179-231 |
1.17e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 56.86 E-value: 1.17e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2128734729 179 LFANYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQK 231
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
1.28e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 58.18 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 360 QILVNMTKNA----NQFTDKGHILIKGWNEETKAIVQII--DDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAI 433
Cdd:cd16920 3 QVLINLVRNGieamSEGGCERRELTIRTSPADDRAVTISvkDTGPGIAEEVAGQLFDPFY-------TTKSEGLGMGLSI 75
|
90 100
....*....|....*....|....*....
gi 2128734729 434 VHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16920 76 CRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
250-462 |
1.42e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 63.54 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 250 VAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKIRSdqivLVKQNFSGANALQNVVDQ 329
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGE----RNTKPFDLSELVTEIAPL 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 330 LQ-------ELAVNkgnelrcECPEDFTVYADYDRFIQILVNMTKNANQ-FTDKGHILI---KGWNEETKA--------- 389
Cdd:PRK13837 533 LRvslppgvELDFD-------QDQEPAVVEGNPAELQQVLMNLCSNAAQaMDGAGRVDIslsRAKLRAPKVlshgvlppg 605
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2128734729 390 -IVQI--IDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:PRK13837 606 rYVLLrvSDTGAGIDEAVLPHIFEPFF-------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
1.91e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.97 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 360 QILVNMTKNANQFT--DKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKvdvSR-KNTKYGE-SGIGLAIVH 435
Cdd:cd16953 3 QVLRNLIGNAISFSppDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYT---ERpANEAFGQhSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 2128734729 436 SLMKSHHGTI----QTESEVGKGTTFTLTFP 462
Cdd:cd16953 80 QIIEAHGGISvaenHNQPGQVIGARFTVQLP 110
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
354-462 |
9.65e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 55.96 E-value: 9.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 354 DYDRFIQILVNMTKNANQFTDKGHiLIKGWNEETK---AIVQIIDDGIGIHEKEVEAIWERFYKVDVSrKNTKYGESGIG 430
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGG-RIRCILEKFRlnrFLLTVSDSGPGIPPNLREEIFERFRQGDGS-STRAHGGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 2128734729 431 LAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16925 79 LSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-461 |
1.81e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 55.72 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 323 LQNVVDQLQELAVNKGNELRCECPEDFTVYADYDRFIQILVNMTKNANQFTDKgHILIKGWNEETKAIVQIIDDGIGIHE 402
Cdd:cd16954 3 LDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLE-FVEVTARQTDGGLHLIVDDDGPGVPE 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 403 KEVEAIWERFYKVDVSRKNtkygeSGIGLAIVHSLMKSHHGTIQ-TESEVGkGTTFTLTF 461
Cdd:cd16954 82 SQRSKIFQRGQRLDEQRPG-----QGLGLAIAKEIVEQYGGELSlSDSPLG-GARFEVVF 135
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-454 |
3.06e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 54.38 E-value: 3.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 360 QILVNMTKNANQFTdKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNtkyGESGIGLAIVHSLMK 439
Cdd:cd16950 3 RVLSNLVDNALRYG-GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT---SGTGLGLAIVQRISD 78
|
90
....*....|....*
gi 2128734729 440 SHHGTIQTESEVGKG 454
Cdd:cd16950 79 AHGGSLTLANRAGGG 93
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-462 |
3.30e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 54.36 E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 362 LVNMTKNANQFTDKgHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTKyGESGIGLAIVHSLMKSH 441
Cdd:cd16939 5 LDNLLRNALRYAHR-TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRAT-GGFGLGLAIVHRVALWH 82
|
90 100
....*....|....*....|..
gi 2128734729 442 HGTIQ-TESEVGkGTTFTLTFP 462
Cdd:cd16939 83 GGHVEcDDSELG-GACFRLTWP 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-462 |
4.65e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 53.54 E-value: 4.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 364 NMTKNANQFT-DKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRkNTkyGESGIGLAIVHSLMKSHH 442
Cdd:cd16923 7 NLLSNAIKYSpENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR-NT--EGAGLGLSIAKAIIELHG 83
|
90 100
....*....|....*....|
gi 2128734729 443 GTIQTESEvGKGTTFTLTFP 462
Cdd:cd16923 84 GSASAEYD-DNHDLFKVRLP 102
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
24-237 |
9.13e-09 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 57.72 E-value: 9.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 24 LLFYNVMTNKIFLQRSQQLFGYAKAILVHDLTADEINSSLSLLKDEHLGVAIFDKNNKMTYPATALNVKSTLTDDELQHL 103
Cdd:COG0840 47 LLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 104 QDGsAINMKQAKHNFVGEAADLVTIYYPIFKNQTYNGFLAISSPLSHIETEMAELRNSILVGFSSAAVVGVILSVLFANY 183
Cdd:COG0840 127 LAI-ALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRS 205
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2128734729 184 QTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQKSEQEIA 237
Cdd:COG0840 206 ITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVR 259
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
182-234 |
1.20e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 51.09 E-value: 1.20e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2128734729 182 NYQTRRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQKSEQ 234
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-462 |
3.81e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 51.25 E-value: 3.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 359 IQILVNMTKNANQFTDKGH--ILIKGWNEETKAI----------VQIIDDGIGIHEKEVEAIwerFYKVDVSRKNTkyge 426
Cdd:cd16918 2 IQVFLNLVRNAAQALAGSGgeIILRTRTQRQVTLghprhrlalrVSVIDNGPGIPPDLQDTI---FYPMVSGRENG---- 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 2128734729 427 SGIGLAIVHSLMKSHHGTIQTESEVGKgTTFTLTFP 462
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
359-467 |
1.10e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 54.15 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 359 IQILVNMTKNA-----NQftDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYkvdvsrkNTKYGESGIGLAI 433
Cdd:PRK11086 435 ITILGNLIENAleavgGE--EGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY-------STKGSNRGVGLYL 505
|
90 100 110
....*....|....*....|....*....|....*.
gi 2128734729 434 VHSLMKSHHGTIQTESEVGKGTTFTLTFP--GKEET 467
Cdd:PRK11086 506 VKQSVENLGGSIAVESEPGVGTQFFVQIPwdGERSN 541
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-461 |
1.44e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 49.77 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 354 DYDRFIQILVNMTKNANQFT-DKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRknTKYGESGIGLA 432
Cdd:cd16975 1 DTLLLSRALINIISNACQYApEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR--RSGGHYGMGLY 78
|
90 100
....*....|....*....|....*....
gi 2128734729 433 IVHSLMKSHHGTIQTESEVGKGTTFTLTF 461
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
186-462 |
1.62e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 53.37 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 186 RRINRLRKATHEIAEGNYDISLPTQKRDEFDDLVMDFNKMAESLQKSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLL 265
Cdd:COG3920 238 LEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKNNLQVVSSLL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 266 eglihHMipESRRERSLELIT--NETQRLIR---LVNENLdYEKIRSDQIVLvkqnfsgANALQNVVDQLQELAVNKGNE 340
Cdd:COG3920 318 -----RL--QARRADDPEAREalEESQNRIQalaLVHELL-YQSEDWEGVDL-------RDYLRELLEPLRDSYGGRGIR 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 341 LRCECPEdftVYADYDRFIQI-------LVNMTKNANQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEkeveaiwerfy 413
Cdd:COG3920 383 IELDGPD---VELPADAAVPLglilnelVTNALKHAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPE----------- 448
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2128734729 414 kvDVSRKNTKygesGIGLAIVHSLMKSHHGTIQTESEvgKGTTFTLTFP 462
Cdd:COG3920 449 --DVDPPARK----GLGLRLIRALVRQLGGTLELDRP--EGTRVRITFP 489
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
389-462 |
2.09e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 49.21 E-value: 2.09e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2128734729 389 AIVQIIDDGIGIHEKEVEAIWERFYkvdvSRKNTkyGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16915 37 LVIEVRDTGPGIAPELRDKVFERGV----STKGQ--GERGIGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
391-462 |
2.46e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 49.30 E-value: 2.46e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2128734729 391 VQIIDDGIGIHEKEVEAIWERFYkvdvSRKNTKYGeSGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16919 50 LEVSDTGSGMPAEVLRRAFEPFF----TTKEVGKG-TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
3.46e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 45.61 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 360 QILVNMTKNANQ-----FTDKGHILIK-GWNEETKAIVQIIDDGIGIHEKEVEAIWERFykVDVSRKNTkygesGIGLAI 433
Cdd:cd16944 7 QVLTNILKNAAEaiegrPSDVGEVRIRvEADQDGRIVLIVCDNGKGFPREMRHRATEPY--VTTRPKGT-----GLGLAI 79
|
90 100
....*....|....*....|....*....
gi 2128734729 434 VHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16944 80 VKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-446 |
3.92e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 45.53 E-value: 3.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 360 QILVNMTKNANQFT-DKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVdvSRKNTKYGESGIGLAIVHSLM 438
Cdd:cd16945 7 QAINNLLDNAIDFSpEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL--PRPHSGQKSTGLGLAFVQEVA 84
|
....*...
gi 2128734729 439 KSHHGTIQ 446
Cdd:cd16945 85 QLHGGRIT 92
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
375-462 |
4.20e-06 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 49.02 E-value: 4.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 375 KGHILIKGWNEETKAIVQIIDDGIGIHekeVEAIWER------------------------FY-------KV-DVS-Rkn 421
Cdd:COG0643 308 TGTITLSAYHEGGRVVIEVSDDGRGLD---LEKIRAKaiekglitaeeaaalsdeelleliFApgfstaeEVtDLSgR-- 382
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2128734729 422 tkygesGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:COG0643 383 ------GVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
391-468 |
4.66e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 48.90 E-value: 4.66e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2128734729 391 VQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTkygesGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFPGKEETE 468
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFTTKEEGKGT-----GLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAE 399
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
244-442 |
5.58e-06 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 48.49 E-value: 5.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 244 RQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITNETQRLIRLVNENLDYEKIRSDQIVLVKQNFSGANAL 323
Cdd:PRK10337 238 RRFTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 324 QNVVDQLQELAVNKGNELRCECPEDFTVYADYDRFIQILV-NMTKNANQFTDKGHILIKGWNEETkaiVQIIDDGIGIHE 402
Cdd:PRK10337 318 QSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVrNLLDNAIRYSPQGSVVDVTLNARN---FTVRDNGPGVTP 394
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2128734729 403 KEVEAIWERFYKvdvSRKNTKYGeSGIGLAIVHSLMKSHH 442
Cdd:PRK10337 395 EALARIGERFYR---PPGQEATG-SGLGLSIVRRIAKLHG 430
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
240-462 |
8.12e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 48.29 E-value: 8.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 240 ENLRrqlmmDVAHEMRTPLTTMNGLLEglihhmipESRRERSLELITNETQRLIRLVNENLDyekIRSDQIVlvkqnfsg 319
Cdd:PRK15053 340 ESLR-----TLRHEHLNWMSTLNGLLQ--------MKEYDRVLEMVQGESQAQQQLIDSLRE---AFADRQV-------- 395
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 320 ANALQNVVDQLQELAVN----KGNELRcECPEDFtvyaDYDRFIQILVNMTKNANQF---TDKGHILIKGW--NEETKAI 390
Cdd:PRK15053 396 AGLLFGKVQRARELGLKmvivPGSQLS-QLPPGL----DSTEFAAIVGNLLDNAFEAslrSDEGNKIVELFlsDEGDDVV 470
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2128734729 391 VQIIDDGIGIHEKEVEAIWERfykvDVSRKNTKYGESGIGLAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:PRK15053 471 IEVADQGCGVPESLRDKIFEQ----GVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
8.30e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 44.37 E-value: 8.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 359 IQILVNMTKNANQFTDK---GHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFYKVDVSRKNTkygesGIGLAIVH 435
Cdd:cd16976 2 QQVLMNLLQNALDAMGKvenPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGT-----GLGLSISY 76
|
90 100
....*....|....*....|....
gi 2128734729 436 SLMKSHHGTIQTESEVGKGTTFTL 459
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTF 100
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
162-462 |
7.20e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 44.22 E-value: 7.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 162 ILVGFSSAAVVGVILSVLFA--NYQTRRINRLRKATHEIAEgnydislptqkrdefddlvmdfnkmaeslqkseQEIARQ 239
Cdd:COG4585 4 LALLGALALLVGALLGLLLAlvLLRARRAERAAELERELAA---------------------------------RAEEAR 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 240 ENLRRQLMMD----VAHEmrtpLTTMNGLLEGLIHHM--IPESRRERsLELITNETQRLI----RLVNEnldyekIRSDQ 309
Cdd:COG4585 51 EEERRRIARElhdgVGQS----LSAIKLQLEAARRLLdaDPEAAREE-LEEIRELAREALaelrRLVRG------LRPPA 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 310 IvlvkQNFSGANALQNVVDQLQELAvnkGNELRCECPEDF---------TVYadydRFIQ-ILVNMTK--NANqftdkgH 377
Cdd:COG4585 120 L----DDLGLAAALEELAERLLRAA---GIRVELDVDGDPdrlppevelALY----RIVQeALTNALKhaGAT------R 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 378 ILIKGWNEETKAIVQIIDDGIGIHEKEVEAiwerfykvdvsrkntkygeSGIGLAIVHSLMKSHHGTIQTESEVGKGTTF 457
Cdd:COG4585 183 VTVTLEVDDGELTLTVRDDGVGFDPEAAPG-------------------GGLGLRGMRERAEALGGTLTIGSAPGGGTRV 243
|
....*
gi 2128734729 458 TLTFP 462
Cdd:COG4585 244 RATLP 248
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
156-231 |
9.16e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 44.84 E-value: 9.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 156 AELRNSILVGFSSAAVVGVILSVLFANYQTRR-----INRLRKATHEIAEGNYD-ISLPTQKRDEFDDLVMDFNKMAESL 229
Cdd:PRK10935 143 AERKLILLAAISLLGLILILTLVFFTVRFTRRqvvapLNQLVTASQQIEKGQFDhIPLDTTLPNELGLLAKAFNQMSSEL 222
|
..
gi 2128734729 230 QK 231
Cdd:PRK10935 223 HK 224
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
373-466 |
1.67e-04 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 43.70 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 373 TDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAiwerfykvdvsrkntkygESGIGLAIVH---SLMKSHHGTIQTES 449
Cdd:COG3275 274 EGGGTISISIEVEGDRLVIEVENNGVGIQPKKKKK------------------GSGIGLKNVRerlELLYGDKYSLEIES 335
|
90
....*....|....*..
gi 2128734729 450 EVGKGTTFTLTFPGKEE 466
Cdd:COG3275 336 TDGGGTKVTLKIPLKKE 352
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
361-462 |
4.97e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 39.90 E-value: 4.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 361 ILVNMTKNANQFTDKGHILIKGWNEETKAIVQIIDDGIGIHEKEVEAIWERFykvdvsrkntkyGESGIGLAIVHSLMKS 440
Cdd:COG2172 42 AVTNAVRHAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTL------------AEGGRGLFLIRRLMDE 109
|
90 100
....*....|....*....|..
gi 2128734729 441 hhgtIQTESEVGkGTTFTLTFP 462
Cdd:COG2172 110 ----VEYESDPG-GTTVRLVKR 126
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
229-462 |
9.77e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 41.84 E-value: 9.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 229 LQKSEQEIARQENLRRQLMMDVAHEMRTPLTTMNGLLEGLIHHMIPESRRERSLELITnETQRLIRLVNENLDYEKIRSD 308
Cdd:PRK10618 436 LQQAQREYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAE-QSDVLVRLVDNIQLLNMLETQ 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 309 QIVLVKQNFSGANALQNVVDQLQELAVNKGNEL--RCECPEDFTVYADYDRFIQILVNMTKNANQFTDKGHILIKGWNEE 386
Cdd:PRK10618 515 DWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLliHNHLKAEQLRIGDRDALRKILLLLLNYAITTTAYGKITLEVDQDE 594
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 387 TKA---IVQIIDDGIGIHEKEV---------EAIWERFYKvdvsrkntkygESGIGLAIVHSLMKSHHGTIQTESEVGKG 454
Cdd:PRK10618 595 SSPdrlTIRILDTGAGVSIKELdnlhfpflnQTQGDRYGK-----------ASGLTFFLCNQLCRKLGGHLTIKSREGLG 663
|
....*...
gi 2128734729 455 TTFTLTFP 462
Cdd:PRK10618 664 TRYSIHLK 671
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
375-462 |
2.03e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 39.10 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 375 KGHILIKGWNEETKAIVQIIDDGIGI-HEKEVEAIWERFYKVDVSRKNtkYGES-----------------------GIG 430
Cdd:cd16916 69 EGTITLRAEHQGNQVVIEVSDDGRGIdREKIREKAIERGLITADEAAT--LSDDevlnlifapgfstaeqvtdvsgrGVG 146
|
90 100 110
....*....|....*....|....*....|..
gi 2128734729 431 LAIVHSLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16916 147 MDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-462 |
4.35e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 36.63 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128734729 359 IQILV-NMTKNAnqFTDK---GHILIKGWNEETKAIVQIIDDGIGIHEKeveaiwerfyKVDVSRKNTKYGESGIGLAIV 434
Cdd:cd16957 6 LQVLVeNAIRHA--FPKRkenNEVRVVVKKDQHKVHVSVSDNGQGIPEE----------RLDLLGKTTVTSEKGTGTALE 73
|
90 100 110
....*....|....*....|....*....|...
gi 2128734729 435 H-----SLMKSHHGTIQTESEVGKGTTFTLTFP 462
Cdd:cd16957 74 NlnrrlIGLFGSEACLHIESEVHGGTEVWFVIP 106
|
|
| |
