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Conserved domains on  [gi|2155095816|ref|WP_229800130|]
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MULTISPECIES: acyltransferase [Shewanella]

Protein Classification

acyltransferase( domain architecture ID 11487035)

acyltransferase such as lysophospholipid acyltransferase (LPLAT) involved in glycerophospholipid biosynthesis

EC:  2.3.-.-
Gene Ontology:  GO:0016746
PubMed:  9259571|18369234

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK14014 PRK14014
putative acyltransferase; Provisional
1-295 1.56e-180

putative acyltransferase; Provisional


:

Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 499.38  E-value: 1.56e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816   1 MSLIRGCLAFSGYVINTLFWSLPILLGSLLKLLP-IKPLQRLCSHFLDICASAWISVNGGIEKLFHPLKMHIDELPELSE 79
Cdd:PRK14014    6 LAPLRGLLSILLLILNTLFWSVPIIILGLLKLLLpIPAIRRACSRLLNFIAEAWISINNVILRLLPRTQWDVEGLEGLSK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  80 QEWYMVVANHQSWVDILILQRLLNRRIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYSTAELKKNPKLRGKDIEITRK 159
Cdd:PRK14014   86 KGWYLVISNHQSWVDILVLQYVFNRRIPMLKFFLKQELIWVPFLGLAWWALDFPFMKRYSKAYLAKNPELKGKDLETTRR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 160 ACAKFKHKPVSVMNFVEGTRFQPSKHQKQNSPFKHLLRPKAGGMAFALSAMGEQIHKLVDVTIYYPGKIPSFWDYISGRL 239
Cdd:PRK14014  166 ACEKFKRMPTTIVNFVEGTRFTPEKHQQQQSPYQHLLKPKAGGIAFALNAMGEQFDGLLDVTIVYPDGRPSFWDLLSGRV 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2155095816 240 PEVYLHLEVKEIDPGMRGDYANDRQFKQAFQERLNALWQHKDEVLERLAAKANHSQ 295
Cdd:PRK14014  246 KKIVVHVRLLPIPEELIGDYFNDKEFRRRFQQWLNQLWQEKDQLIEQLLAQYNQNK 301
 
Name Accession Description Interval E-value
PRK14014 PRK14014
putative acyltransferase; Provisional
1-295 1.56e-180

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 499.38  E-value: 1.56e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816   1 MSLIRGCLAFSGYVINTLFWSLPILLGSLLKLLP-IKPLQRLCSHFLDICASAWISVNGGIEKLFHPLKMHIDELPELSE 79
Cdd:PRK14014    6 LAPLRGLLSILLLILNTLFWSVPIIILGLLKLLLpIPAIRRACSRLLNFIAEAWISINNVILRLLPRTQWDVEGLEGLSK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  80 QEWYMVVANHQSWVDILILQRLLNRRIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYSTAELKKNPKLRGKDIEITRK 159
Cdd:PRK14014   86 KGWYLVISNHQSWVDILVLQYVFNRRIPMLKFFLKQELIWVPFLGLAWWALDFPFMKRYSKAYLAKNPELKGKDLETTRR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 160 ACAKFKHKPVSVMNFVEGTRFQPSKHQKQNSPFKHLLRPKAGGMAFALSAMGEQIHKLVDVTIYYPGKIPSFWDYISGRL 239
Cdd:PRK14014  166 ACEKFKRMPTTIVNFVEGTRFTPEKHQQQQSPYQHLLKPKAGGIAFALNAMGEQFDGLLDVTIVYPDGRPSFWDLLSGRV 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2155095816 240 PEVYLHLEVKEIDPGMRGDYANDRQFKQAFQERLNALWQHKDEVLERLAAKANHSQ 295
Cdd:PRK14014  246 KKIVVHVRLLPIPEELIGDYFNDKEFRRRFQQWLNQLWQEKDQLIEQLLAQYNQNK 301
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
81-247 4.41e-44

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 148.54  E-value: 4.41e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  81 EWYMVVANHQSWVDILILQRLLNR--RIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYSTaelkknpklrgKDIEITR 158
Cdd:cd07990    24 ERALIISNHRSEVDWLVLWMLADRfgRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWE-----------KDEKTIK 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 159 KACAKFK--HKPVSVMNFVEGTRFQPSKHQKQNS--------PFKHLLRPKAGGMAFALSAMGEQIHKLVDVTIYYPGKI 228
Cdd:cd07990    93 RQLKRLKdsPEPFWLLIFPEGTRFTEEKKERSQEfaeknglpPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIAYPDGK 172
                         170       180
                  ....*....|....*....|.
gi 2155095816 229 PSFW-DYISGRLP-EVYLHLE 247
Cdd:cd07990   173 PPSEqRLLLGGKPrEVHVHVR 193
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
67-276 3.69e-24

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 97.39  E-value: 3.69e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  67 LKMHIDELPELSEQEWYMVVANHQSWVDILILQRLLNRRIpflKFFLKKELIYVPVLGLAWWALDFPFMRRYStaelkkn 146
Cdd:COG0204    29 VRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPV---RFVAKKELFKIPLLGWLLRALGAIPVDRSK------- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 147 pklRGKDIEITRKACAKFKhKPVSVMNFVEGTRfqpskhqkqnSPFKHLLRPKAGGMAFALSAmGEQIhklVDVTIYYPG 226
Cdd:COG0204    99 ---RRAALRALRQAVEALK-AGESLVIFPEGTR----------SPDGRLLPFKTGAARLALEA-GVPI---VPVAIDGTE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2155095816 227 KIPSFWDYISGRLPEVYLHlevKEIDPGMRGDyANDRQFKQAFQERLNAL 276
Cdd:COG0204   161 RALPKGFLPRPGKVTVRIG---PPIDPSDLEG-EDRRELAERLRAAIEAL 206
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
83-224 9.73e-21

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 85.48  E-value: 9.73e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816   83 YMVVANHQSWVDILILQRLLNRRIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYStaelkknpklRGKDIEITRKACA 162
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSN----------GRKARAALREAVE 70
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2155095816  163 KFKhKPVSVMNFVEGTRFQPSKhqkqnspfkhLLRPKAGgmAFALSAMGEqiHKLVDVTIYY 224
Cdd:smart00563  71 LLK-EGEWLLIFPEGTRSRPGK----------LLPFKKG--AARLALEAG--VPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
85-193 1.50e-10

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 58.06  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  85 VVANHQSWVDILILQRLLNRRIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYStaelkknpklrgkdieitRKACAKF 164
Cdd:pfam01553  18 VVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKN------------------RKDAAGT 79
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2155095816 165 KHKPVSVMN-------FVEGTRFQPSKHqkqnSPFK 193
Cdd:pfam01553  80 LEYLVELLRegklvviFPEGTRSREGEL----LPFK 111
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
83-179 2.23e-10

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 57.36  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  83 YMVVANHQSWVDILILQRLLNRRIPFLKfflKKELIYVPVLGLAWWALDFPFMRRYSTaelkknpklrgKDIEITRKACA 162
Cdd:TIGR00530  18 VLVVANHQSNLDPLTLSAAFPPPIVFIA---KKELKWIPFFGIMLWLTGAIFIDRENI-----------RAIATALKAAI 83
                          90
                  ....*....|....*..
gi 2155095816 163 KFKHKPVSVMNFVEGTR 179
Cdd:TIGR00530  84 EVLKQGRSIGVFPEGTR 100
 
Name Accession Description Interval E-value
PRK14014 PRK14014
putative acyltransferase; Provisional
1-295 1.56e-180

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 499.38  E-value: 1.56e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816   1 MSLIRGCLAFSGYVINTLFWSLPILLGSLLKLLP-IKPLQRLCSHFLDICASAWISVNGGIEKLFHPLKMHIDELPELSE 79
Cdd:PRK14014    6 LAPLRGLLSILLLILNTLFWSVPIIILGLLKLLLpIPAIRRACSRLLNFIAEAWISINNVILRLLPRTQWDVEGLEGLSK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  80 QEWYMVVANHQSWVDILILQRLLNRRIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYSTAELKKNPKLRGKDIEITRK 159
Cdd:PRK14014   86 KGWYLVISNHQSWVDILVLQYVFNRRIPMLKFFLKQELIWVPFLGLAWWALDFPFMKRYSKAYLAKNPELKGKDLETTRR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 160 ACAKFKHKPVSVMNFVEGTRFQPSKHQKQNSPFKHLLRPKAGGMAFALSAMGEQIHKLVDVTIYYPGKIPSFWDYISGRL 239
Cdd:PRK14014  166 ACEKFKRMPTTIVNFVEGTRFTPEKHQQQQSPYQHLLKPKAGGIAFALNAMGEQFDGLLDVTIVYPDGRPSFWDLLSGRV 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2155095816 240 PEVYLHLEVKEIDPGMRGDYANDRQFKQAFQERLNALWQHKDEVLERLAAKANHSQ 295
Cdd:PRK14014  246 KKIVVHVRLLPIPEELIGDYFNDKEFRRRFQQWLNQLWQEKDQLIEQLLAQYNQNK 301
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
81-247 4.41e-44

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 148.54  E-value: 4.41e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  81 EWYMVVANHQSWVDILILQRLLNR--RIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYSTaelkknpklrgKDIEITR 158
Cdd:cd07990    24 ERALIISNHRSEVDWLVLWMLADRfgRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWE-----------KDEKTIK 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 159 KACAKFK--HKPVSVMNFVEGTRFQPSKHQKQNS--------PFKHLLRPKAGGMAFALSAMGEQIHKLVDVTIYYPGKI 228
Cdd:cd07990    93 RQLKRLKdsPEPFWLLIFPEGTRFTEEKKERSQEfaeknglpPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIAYPDGK 172
                         170       180
                  ....*....|....*....|.
gi 2155095816 229 PSFW-DYISGRLP-EVYLHLE 247
Cdd:cd07990   173 PPSEqRLLLGGKPrEVHVHVR 193
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
67-276 3.69e-24

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 97.39  E-value: 3.69e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  67 LKMHIDELPELSEQEWYMVVANHQSWVDILILQRLLNRRIpflKFFLKKELIYVPVLGLAWWALDFPFMRRYStaelkkn 146
Cdd:COG0204    29 VRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPV---RFVAKKELFKIPLLGWLLRALGAIPVDRSK------- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 147 pklRGKDIEITRKACAKFKhKPVSVMNFVEGTRfqpskhqkqnSPFKHLLRPKAGGMAFALSAmGEQIhklVDVTIYYPG 226
Cdd:COG0204    99 ---RRAALRALRQAVEALK-AGESLVIFPEGTR----------SPDGRLLPFKTGAARLALEA-GVPI---VPVAIDGTE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2155095816 227 KIPSFWDYISGRLPEVYLHlevKEIDPGMRGDyANDRQFKQAFQERLNAL 276
Cdd:COG0204   161 RALPKGFLPRPGKVTVRIG---PPIDPSDLEG-EDRRELAERLRAAIEAL 206
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
83-224 9.73e-21

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 85.48  E-value: 9.73e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816   83 YMVVANHQSWVDILILQRLLNRRIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYStaelkknpklRGKDIEITRKACA 162
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSN----------GRKARAALREAVE 70
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2155095816  163 KFKhKPVSVMNFVEGTRFQPSKhqkqnspfkhLLRPKAGgmAFALSAMGEqiHKLVDVTIYY 224
Cdd:smart00563  71 LLK-EGEWLLIFPEGTRSRPGK----------LLPFKKG--AARLALEAG--VPIVPVAIRG 117
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
83-209 5.52e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 68.84  E-value: 5.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  83 YMVVANHQSWVDILILQRLLNRRIpflKFFLKKELIYVPVLGLAWWALDFPFMRRYStaelkknpklRGKDIEITRKACA 162
Cdd:cd07989    26 VIIVANHQSYLDPLVLGAALPRPI---RFVAKKELFKIPFLGWLLRLLGAIPIDRGN----------GRSAREALREAIE 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2155095816 163 KFKHKpVSVMNFVEGTRfqpskhqkqnSPFKHLLRPKAGGMAFALSA 209
Cdd:cd07989    93 ALKEG-ESVVIFPEGTR----------SRDGELLPFKSGAFRLAKEA 128
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
85-193 1.50e-10

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 58.06  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  85 VVANHQSWVDILILQRLLNRRIPFLKFFLKKELIYVPVLGLAWWALDFPFMRRYStaelkknpklrgkdieitRKACAKF 164
Cdd:pfam01553  18 VVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKN------------------RKDAAGT 79
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2155095816 165 KHKPVSVMN-------FVEGTRFQPSKHqkqnSPFK 193
Cdd:pfam01553  80 LEYLVELLRegklvviFPEGTRSREGEL----LPFK 111
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
83-179 2.23e-10

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 57.36  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  83 YMVVANHQSWVDILILQRLLNRRIPFLKfflKKELIYVPVLGLAWWALDFPFMRRYSTaelkknpklrgKDIEITRKACA 162
Cdd:TIGR00530  18 VLVVANHQSNLDPLTLSAAFPPPIVFIA---KKELKWIPFFGIMLWLTGAIFIDRENI-----------RAIATALKAAI 83
                          90
                  ....*....|....*..
gi 2155095816 163 KFKHKPVSVMNFVEGTR 179
Cdd:TIGR00530  84 EVLKQGRSIGVFPEGTR 100
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
84-251 1.19e-09

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 58.56  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  84 MVVANHQSWVDILILQRLLNR--RIPFLKFFLKKELIYVPVLGLAWWALDF-PFMRRYSTaelkknpklrgkDIEITRKA 160
Cdd:PLN02510   95 LLIANHRTEVDWMYLWDLALRkgCLGYIKYVLKSSLMKLPVFGWAFHIFEFiPVERKWEV------------DEPNIRQM 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 161 CAKFKHK--PVSVMNFVEGTRFQPSKHQKQNS--------PFKHLLRPKAGGMAFALSAMGEQIHKLVDVTIYYPGKIPS 230
Cdd:PLN02510  163 LSSFKDPrdPLWLALFPEGTDYTEAKCQRSQKfaaehglpILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGYKHRCPS 242
                         170       180
                  ....*....|....*....|....*
gi 2155095816 231 FWDYISGRLP-EVYLH---LEVKEI 251
Cdd:PLN02510  243 FLDNVFGIDPsEVHIHirrIPLKQI 267
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
72-247 1.02e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 43.19  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  72 DELPELSEQEWYMVVANHQSWVDILILQrLLNRRIPFLKFFL---KKELIYVPVLGLAWWALDFPFMRRYstaelkknpk 148
Cdd:PLN02380   75 EETFELMGKEHALVISNHRSDIDWLVGW-ILAQRSGCLGSALavmKKSSKFLPVIGWSMWFSEYVFLERS---------- 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 149 lRGKDIEITRKACAKFKHKPVS--VMNFVEGTRFQPSK---HQK----QNSPF-KHLLRPKAGGMAFALSAMGEQIHKLV 218
Cdd:PLN02380  144 -WAKDENTLKSGFQRLKDFPRPfwLALFVEGTRFTQAKllaAQEyaasRGLPVpRNVLIPRTKGFVSAVSNMRSFVPAIY 222
                         170       180       190
                  ....*....|....*....|....*....|.
gi 2155095816 219 DVTIYYPGK--IPSFWDYISGRLPEVYLHLE 247
Cdd:PLN02380  223 DVTVAVPKGqpAPTMLRIFRGQSSVVHVHIK 253
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
45-179 1.19e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 42.41  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  45 FLDICASAWISVNggiEKLFHPLKMH-IDELPELSEQEWYmvVANHQSWVDILILQRLlnrRIPFlKFFLKKELIYVPVL 123
Cdd:PLN02901   18 AQHFINKVWATLS---TSPFYKIEVEgLENLPSPDEPAVY--VSNHQSFLDIYTLFHL---GRPF-KFISKTSIFLIPII 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2155095816 124 GLAWWALD-FPFMRRYSTAELKknpklrgkdieiTRKACAKFKHKPVSVMNFVEGTR 179
Cdd:PLN02901   89 GWAMYMTGhIPLKRMDRRSQLE------------CLKRCMELLKKGASVFFFPEGTR 133
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
83-245 6.67e-04

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 39.70  E-value: 6.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816  83 YMVVANHQSWVDILILQRLLNRRIPFLKFFLKKE--LIYVPVLGlawWALDFPFMRRystaelkkNPKLRGKDIeitRKA 160
Cdd:cd06551    28 VLFVSNHSSWWDGLILFLLLERGLRRDVYGLMDEelLERYPFFT---RLGAFSVDRD--------SPRSAAKSL---KYV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155095816 161 CAKFKHKPVSVMNFVEGTRfqpsKHQKqnspfKHLLRPKAGgmafaLSAMGEQIH-KLVDVTIYYpgkipSFWDYIsgRL 239
Cdd:cd06551    94 ARLLSKPGSVVWIFPEGTR----TRRD-----KRPLQFKPG-----VAHLAEKAGvPIVPVALRY-----TFELFE--QF 152

                  ....*.
gi 2155095816 240 PEVYLH 245
Cdd:cd06551   153 PEIFVR 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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