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Conserved domains on  [gi|2155127853|ref|WP_229822681|]
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SLATT domain-containing protein [Streptomyces netropsis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLATT_2 pfam18183
SMODS and SLOG-associating 2TM effector domain 2; The SLATT domain contains two transmembrane ...
 22-213 4.21e-120

SMODS and SLOG-associating 2TM effector domain 2; The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is the only prokaryotic SLATT family to exist as a standalone domain, with no as-yet discernable genome associations.


:

Pssm-ID: 436332  Cd Length: 192  Bit Score: 339.81  E-value: 4.21e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853  22 DLRGRTFPLGNWGEPAERLDELYRWVEDGALYLADWYLADRAWKRRWARGLRVGAALCAVVGAALPLLELTKVVRTGSAW 101
Cdd:pfam18183   1 DLTGRPFPLGDWGEPAERLDELYRWVEEGALRTADWYLADRVWKRRGARALRAGAAVGAVAGAALPLLDLTGVLPGAAPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853 102 GFLALLGAAACVACDRYFGLTTGWMRAVATAQAVQRRLEALQFDWASECVREVLGPTEGTASEAAERCLSVLRRFSEDVS 181
Cdd:pfam18183  81 GYLALLLAAACVACDRFFGLTSGWMRDVATAQAVQRRLQALQFDWASECVREVLGPTEGTASEAAERCLGVLRRFSEDVT 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2155127853 182 ELVRAETADWMVEFRAGPAPLLTQSLVSWGPR 213
Cdd:pfam18183 161 ELVRAETADWMVEFRSGPAPLATQALVPWGPR 192
 
Name Accession Description Interval E-value
SLATT_2 pfam18183
SMODS and SLOG-associating 2TM effector domain 2; The SLATT domain contains two transmembrane ...
 22-213 4.21e-120

SMODS and SLOG-associating 2TM effector domain 2; The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is the only prokaryotic SLATT family to exist as a standalone domain, with no as-yet discernable genome associations.


Pssm-ID: 436332  Cd Length: 192  Bit Score: 339.81  E-value: 4.21e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853  22 DLRGRTFPLGNWGEPAERLDELYRWVEDGALYLADWYLADRAWKRRWARGLRVGAALCAVVGAALPLLELTKVVRTGSAW 101
Cdd:pfam18183   1 DLTGRPFPLGDWGEPAERLDELYRWVEEGALRTADWYLADRVWKRRGARALRAGAAVGAVAGAALPLLDLTGVLPGAAPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853 102 GFLALLGAAACVACDRYFGLTTGWMRAVATAQAVQRRLEALQFDWASECVREVLGPTEGTASEAAERCLSVLRRFSEDVS 181
Cdd:pfam18183  81 GYLALLLAAACVACDRFFGLTSGWMRDVATAQAVQRRLQALQFDWASECVREVLGPTEGTASEAAERCLGVLRRFSEDVT 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2155127853 182 ELVRAETADWMVEFRAGPAPLLTQSLVSWGPR 213
Cdd:pfam18183 161 ELVRAETADWMVEFRSGPAPLATQALVPWGPR 192
SLATT_2 NF033633
SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally ...
 23-204 7.68e-94

SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is the only prokaryotic SLATT family to exist as a standalone domain, with no as-yet discernable genome associations.


Pssm-ID: 468119  Cd Length: 181  Bit Score: 273.09  E-value: 7.68e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853  23 LRGRTFPLGNWGEPAERLDELYRWVEDGALYLADWYLADRAWKRRWARGLRVGAALCAVVGAALPLLELTKVVRtGSAWG 102
Cdd:NF033633    1 LAGRPFPLGDWGEPAERLDELYRWAEAEALETIDWYLADRRVKRRASRVLRALAALGAVAGALLPLLALTGVPG-LTQWG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853 103 FLALLGAAACVACDRYFGLTTGWMRAVATAQAVQRRLEALQFDWASECVREVLGPTEGTASEAAERCLSVLRRFSEDVSE 182
Cdd:NF033633   80 YVALALAAGCVAADRYFGLSSGWMRDIATAQALQRRLEAFQFDWASESVREVLGPTEGTASEAAERCLGVLRRFSEDVSE 159

                         170       180
                  ....*....|....*....|..
gi 2155127853 183 LVRAETADWMVEFRAGPAPLLT 204
Cdd:NF033633  160 LVRAETADWMSEFRAGLEPLPT 181
SLATT_1 NF033634
SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally ...
 56-192 1.67e-05

SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is often C-terminally fused to the SLATT_3 family, and is typically operonically linked to either inactive TIR domains or SLOG domains which could act as regulators of the SLATT channels. In relatively rare instances, it is genomically linked as a standalone domain to the RelA/SpoT nucleotide synthetase and the predicted NA37/YejK sensor domain.


Pssm-ID: 468120  Cd Length: 135  Bit Score: 43.14  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853  56 DWYLADRAWKRRWARGLRVGAALCAVVGAALPLLELTKVVRTGSAWGFLALLGA--AACVACDRYFGLTTGWMRAVATAQ 133
Cdd:NF033634   11 DWYRKKARRNRRRYRRLRVLTIVLSAAIPVLLALLRAGGPSAALLWDIALVLSAlvAALAAWLQLFRYQELWIAYRLTAE 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2155127853 134 avqrRLEALQFDWAsecvrevLGPTEGTASEAAerclsvLRRFSEDVSELVRAETADWM 192
Cdd:NF033634   91 ----ELKREKDLYE-------LLSGPYRADEEA------FALFVERVESIISREHTQWL 132
 
Name Accession Description Interval E-value
SLATT_2 pfam18183
SMODS and SLOG-associating 2TM effector domain 2; The SLATT domain contains two transmembrane ...
 22-213 4.21e-120

SMODS and SLOG-associating 2TM effector domain 2; The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is the only prokaryotic SLATT family to exist as a standalone domain, with no as-yet discernable genome associations.


Pssm-ID: 436332  Cd Length: 192  Bit Score: 339.81  E-value: 4.21e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853  22 DLRGRTFPLGNWGEPAERLDELYRWVEDGALYLADWYLADRAWKRRWARGLRVGAALCAVVGAALPLLELTKVVRTGSAW 101
Cdd:pfam18183   1 DLTGRPFPLGDWGEPAERLDELYRWVEEGALRTADWYLADRVWKRRGARALRAGAAVGAVAGAALPLLDLTGVLPGAAPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853 102 GFLALLGAAACVACDRYFGLTTGWMRAVATAQAVQRRLEALQFDWASECVREVLGPTEGTASEAAERCLSVLRRFSEDVS 181
Cdd:pfam18183  81 GYLALLLAAACVACDRFFGLTSGWMRDVATAQAVQRRLQALQFDWASECVREVLGPTEGTASEAAERCLGVLRRFSEDVT 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2155127853 182 ELVRAETADWMVEFRAGPAPLLTQSLVSWGPR 213
Cdd:pfam18183 161 ELVRAETADWMVEFRSGPAPLATQALVPWGPR 192
SLATT_2 NF033633
SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally ...
 23-204 7.68e-94

SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is the only prokaryotic SLATT family to exist as a standalone domain, with no as-yet discernable genome associations.


Pssm-ID: 468119  Cd Length: 181  Bit Score: 273.09  E-value: 7.68e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853  23 LRGRTFPLGNWGEPAERLDELYRWVEDGALYLADWYLADRAWKRRWARGLRVGAALCAVVGAALPLLELTKVVRtGSAWG 102
Cdd:NF033633    1 LAGRPFPLGDWGEPAERLDELYRWAEAEALETIDWYLADRRVKRRASRVLRALAALGAVAGALLPLLALTGVPG-LTQWG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853 103 FLALLGAAACVACDRYFGLTTGWMRAVATAQAVQRRLEALQFDWASECVREVLGPTEGTASEAAERCLSVLRRFSEDVSE 182
Cdd:NF033633   80 YVALALAAGCVAADRYFGLSSGWMRDIATAQALQRRLEAFQFDWASESVREVLGPTEGTASEAAERCLGVLRRFSEDVSE 159

                         170       180
                  ....*....|....*....|..
gi 2155127853 183 LVRAETADWMVEFRAGPAPLLT 204
Cdd:NF033633  160 LVRAETADWMSEFRAGLEPLPT 181
SLATT_1 NF033634
SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally ...
 56-192 1.67e-05

SLATT domain; The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is often C-terminally fused to the SLATT_3 family, and is typically operonically linked to either inactive TIR domains or SLOG domains which could act as regulators of the SLATT channels. In relatively rare instances, it is genomically linked as a standalone domain to the RelA/SpoT nucleotide synthetase and the predicted NA37/YejK sensor domain.


Pssm-ID: 468120  Cd Length: 135  Bit Score: 43.14  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2155127853  56 DWYLADRAWKRRWARGLRVGAALCAVVGAALPLLELTKVVRTGSAWGFLALLGA--AACVACDRYFGLTTGWMRAVATAQ 133
Cdd:NF033634   11 DWYRKKARRNRRRYRRLRVLTIVLSAAIPVLLALLRAGGPSAALLWDIALVLSAlvAALAAWLQLFRYQELWIAYRLTAE 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2155127853 134 avqrRLEALQFDWAsecvrevLGPTEGTASEAAerclsvLRRFSEDVSELVRAETADWM 192
Cdd:NF033634   91 ----ELKREKDLYE-------LLSGPYRADEEA------FALFVERVESIISREHTQWL 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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