NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2162112566|ref|WP_231358575|]
View 

F0F1 ATP synthase subunit A [Merdimmobilis hominis]

Protein Classification

F0F1 ATP synthase subunit A( domain architecture ID 10001246)

F0F1 ATP synthase subunit A is part of the membrane proton channel of the F-type ATPase that produces ATP from ADP in the presence of a proton gradient across the membrane; it plays a direct role in the translocation of protons across the membrane

Gene Ontology:  GO:0045263|GO:0046933|GO:0005886|GO:0015986
PubMed:  28001127|11533110|12370007

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 22-235 7.48e-54

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


:

Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 172.18  E-value: 7.48e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  22 ETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNMLGLF-GL 100
Cdd:COG0356     1 DTVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIpGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 101 RAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDPP------IVTPLNLISEFSTPVSMAFRHFGNIAAGLIIT 174
Cdd:COG0356    81 FPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHLFFPPfpwlapLMLPIEIISELARPLSLSLRLFGNMFAGHIIL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2162112566 175 TLLYGALTGLTHMVFGANFQIPILaiglpavlsvYFDLFTAFMQAFIISMLTMVFTSMAMD 235
Cdd:COG0356   161 LLLAGLAPFLLLGVLSLLLPVAWT----------AFELLVGFLQAYIFTMLTAVYISLAVE 211
 
Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 22-235 7.48e-54

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 172.18  E-value: 7.48e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  22 ETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNMLGLF-GL 100
Cdd:COG0356     1 DTVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIpGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 101 RAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDPP------IVTPLNLISEFSTPVSMAFRHFGNIAAGLIIT 174
Cdd:COG0356    81 FPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHLFFPPfpwlapLMLPIEIISELARPLSLSLRLFGNMFAGHIIL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2162112566 175 TLLYGALTGLTHMVFGANFQIPILaiglpavlsvYFDLFTAFMQAFIISMLTMVFTSMAMD 235
Cdd:COG0356   161 LLLAGLAPFLLLGVLSLLLPVAWT----------AFELLVGFLQAYIFTMLTAVYISLAVE 211
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 12-235 8.58e-46

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 151.87  E-value: 8.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  12 IPVLGGIPISETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFF 91
Cdd:PRK05815    6 IIGFGGFNFDSLLLSVLLGVLILLLFALVATRKLSGVPGGLQNFVEMIVEFVRGQVKDNIGGKGKKFAPLAFTLFLFILL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  92 SNMLGLF--GLRAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDPP--IVTPLNLISEFSTPVSMAFRHFGNI 167
Cdd:PRK05815   86 MNLLGLIpyLLFPPTADINVTLALALIVFVLVIYYGIKKKGLGGYLKEFYLQPhpLLLPIEIISEFSRPISLSLRLFGNM 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2162112566 168 AAGLIITTLLYgaltglthMVFGANFQIPILAIGLPAVLSvYFDLFTAFMQAFIISMLTMVFTSMAMD 235
Cdd:PRK05815  166 LAGELILALIA--------LLGGAGLLLALAPLILPVAWT-IFEIFVGTLQAYIFMMLTIVYISMAVE 224
ATP-synt_A pfam00119
ATP synthase A chain;
24-231 1.90e-42

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 143.01  E-value: 1.90e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  24 VVNSWIVMAILVIGSMLLTRNLQK-VPKGAQVLVEKVVETLYSFVESTMG-KDKVFFAPYIGTLFLFSFFSNMLGLF--- 98
Cdd:pfam00119   1 LLMSLIVALILLLFLLLATRKTKKlVPGRLQNFVEMLVEFVDNIVKDNIGkKKGRKFFPLLLTLFFFILVSNLLGLIpks 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  99 -GLRAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDP-------PIVTPLNLISEFSTPVSMAFRHFGNIAAG 170
Cdd:pfam00119  81 pGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFVPpvplplvPLLLPIEIISEFARPVSLSLRLFGNMLAG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2162112566 171 LIITTLLYGALTGLTHMVFGANFQIPILAIGLpavlsVYFDLFTAFMQAFIISMLTMVFTS 231
Cdd:pfam00119 161 HLLLLLLAGLIFALLSAGFLLGVIPPLLGVAW-----TLFELLVAFIQAYVFTMLTAVYIS 216
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 26-231 1.04e-18

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 81.48  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  26 NSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNMLGLFGLR-APT 104
Cdd:TIGR01131  18 LSLILLLSLLIFLISSSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIFTLFLFILISNLLGLIPYSfTPT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 105 ADINTTACWAFIEFMLVqIFSIKRKGVIGRIKGLCDP-------PIVTPLNLISEFSTPVSMAFRHFGNIAAGLIITTLL 177
Cdd:TIGR01131  98 SHLSFTLGLALPLWLGL-TISGFRKHPKGFLAHLVPSgtplpliPFLVIIETISYLARPISLSVRLFANISAGHLLLTLL 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2162112566 178 YGALTGLTHMVFGANFQIPILAIGLpavlsvyFDLFTAFMQAFIISMLTMVFTS 231
Cdd:TIGR01131 177 SGLLFSLMSSAIFALLLLILVALII-------LEIFVAFIQAYVFTLLTCLYLN 223
 
Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 22-235 7.48e-54

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 172.18  E-value: 7.48e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  22 ETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNMLGLF-GL 100
Cdd:COG0356     1 DTVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIpGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 101 RAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDPP------IVTPLNLISEFSTPVSMAFRHFGNIAAGLIIT 174
Cdd:COG0356    81 FPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHLFFPPfpwlapLMLPIEIISELARPLSLSLRLFGNMFAGHIIL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2162112566 175 TLLYGALTGLTHMVFGANFQIPILaiglpavlsvYFDLFTAFMQAFIISMLTMVFTSMAMD 235
Cdd:COG0356   161 LLLAGLAPFLLLGVLSLLLPVAWT----------AFELLVGFLQAYIFTMLTAVYISLAVE 211
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 12-235 8.58e-46

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 151.87  E-value: 8.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  12 IPVLGGIPISETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFF 91
Cdd:PRK05815    6 IIGFGGFNFDSLLLSVLLGVLILLLFALVATRKLSGVPGGLQNFVEMIVEFVRGQVKDNIGGKGKKFAPLAFTLFLFILL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  92 SNMLGLF--GLRAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDPP--IVTPLNLISEFSTPVSMAFRHFGNI 167
Cdd:PRK05815   86 MNLLGLIpyLLFPPTADINVTLALALIVFVLVIYYGIKKKGLGGYLKEFYLQPhpLLLPIEIISEFSRPISLSLRLFGNM 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2162112566 168 AAGLIITTLLYgaltglthMVFGANFQIPILAIGLPAVLSvYFDLFTAFMQAFIISMLTMVFTSMAMD 235
Cdd:PRK05815  166 LAGELILALIA--------LLGGAGLLLALAPLILPVAWT-IFEIFVGTLQAYIFMMLTIVYISMAVE 224
ATP-synt_A pfam00119
ATP synthase A chain;
24-231 1.90e-42

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 143.01  E-value: 1.90e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  24 VVNSWIVMAILVIGSMLLTRNLQK-VPKGAQVLVEKVVETLYSFVESTMG-KDKVFFAPYIGTLFLFSFFSNMLGLF--- 98
Cdd:pfam00119   1 LLMSLIVALILLLFLLLATRKTKKlVPGRLQNFVEMLVEFVDNIVKDNIGkKKGRKFFPLLLTLFFFILVSNLLGLIpks 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  99 -GLRAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDP-------PIVTPLNLISEFSTPVSMAFRHFGNIAAG 170
Cdd:pfam00119  81 pGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFVPpvplplvPLLLPIEIISEFARPVSLSLRLFGNMLAG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2162112566 171 LIITTLLYGALTGLTHMVFGANFQIPILAIGLpavlsVYFDLFTAFMQAFIISMLTMVFTS 231
Cdd:pfam00119 161 HLLLLLLAGLIFALLSAGFLLGVIPPLLGVAW-----TLFELLVAFIQAYVFTMLTAVYIS 216
PRK13421 PRK13421
F0F1 ATP synthase subunit A; Provisional
 15-234 3.22e-35

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237383  Cd Length: 223  Bit Score: 124.81  E-value: 3.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  15 LGGIPISETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNM 94
Cdd:PRK13421   14 LGPVPISAPVVVTWAIMAVLAAGSALATRRLSLAPGRLQSVLELVVTTIDAQIRDTMQTDPAPYRALIGTLFLFVLVANW 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  95 LGLF-GLRAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDP-PIVTPLNLISEFSTPVSMAFRHFGNIAAGLI 172
Cdd:PRK13421   94 SSLVpGVEPPTAHLETDAALALIVFLATIYYGVRARGVRGYLATFAEPtWVMIPLNLVEQLTRTFSLIVRLFGNVMSGVF 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2162112566 173 ITTLLYgALTGLThmvfganFQIPILAIglpavlsvyfDLFTAFMQAFIISMLTMVFTSMAM 234
Cdd:PRK13421  174 VIGIVL-SLAGLL-------VPIPLMAL----------DLLTGAVQAYIFAVLAMVFIGAAV 217
PRK13420 PRK13420
F0F1 ATP synthase subunit A; Provisional
 15-234 4.77e-30

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237382 [Multi-domain]  Cd Length: 226  Bit Score: 111.37  E-value: 4.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  15 LGGIPISETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNM 94
Cdd:PRK13420   11 IGPLPITESVLTTWGIMIVLVLASWLTTRRLSLDPGRFQVALEGVVSTIEDAIKEVLPRHARLVLPFVGTLWIFILVANL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  95 LGLF-GLRAPTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCDP-PIVTPLNLISEFSTPVSMAFRHFGNIAAGLI 172
Cdd:PRK13420   91 IGLIpGFHSPTADLSVTAALALLVFFSVHWFGIRAEGLREYLKHYLSPsPFLLPFHLISEITRTLALAVRLFGNIMSLEL 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2162112566 173 ITTLLYgaltglthMVFGANFQIPILAIglpavlsvyfDLFTAFMQAFIISMLTMVFTSMAM 234
Cdd:PRK13420  171 AALLVL--------LVAGFLVPVPILML----------HIIEALVQAYIFGMLALIYIAGGI 214
atpI CHL00046
ATP synthase CF0 A subunit
 22-226 1.56e-26

ATP synthase CF0 A subunit


Pssm-ID: 176987  Cd Length: 228  Bit Score: 102.32  E-value: 1.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  22 ETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVF-FAPYIGTLFLFSFFSNMLG-LFG 99
Cdd:CHL00046   24 QVLITSWVVIAILLGSALLATRNLQTIPTGGQNFFEYVLEFIRDLAKTQIGEEEYRpWVPFIGTMFLFIFVSNWSGaLLP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 100 LR----------APTADINTTACWAfiefMLVQIFS----IKRKGvIGRIKGLCDP-PIVTPLNLISEFSTPVSMAFRHF 164
Cdd:CHL00046  104 WKlielphgelaAPTNDINTTVALA----LLTSVAYfyagLSKKG-LGYFGKYIQPtPILLPINILEDFTKPLSLSFRLF 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2162112566 165 GNIAAgliiTTLLYGALTGLTHMVfganFQIPILAIGlpavlsvyfdLFTAFMQAFIISMLT 226
Cdd:CHL00046  179 GNILA----DELVVAVLVSLVPLV----VPIPVMFLG----------LFTSGIQALIFATLA 222
PRK13419 PRK13419
F0F1 ATP synthase subunit A; Provisional
 14-233 6.09e-21

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237381  Cd Length: 342  Bit Score: 89.42  E-value: 6.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  14 VLGGIPISET--VVNSWIVMAILVI-----GSMLLTRNLQKVPKGAQVLVEKVVETLYSFV-ESTMGKDKVFFAPYIGTL 85
Cdd:PRK13419   98 VVGGFDISITkhVVMMWIASAILLVvflaaGRKYKKMTKSQAPKGLANAMEALVEFIRLDVaKSNIGHGYEKFLPYLLTV 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  86 FLFSFFSNMLGL--FGLRApTADINTTACWAFIEFMLVQIFSIKRKGVIGRIKGLCD--PP----IVTPLNLISEFSTPV 157
Cdd:PRK13419  178 FFFILVCNLLGLvpYGATA-TGNINVTLTLAVFTFFITQYAAIKAHGIKGYLAHLTGgtHWslwiIMIPIEFIGLFTKPF 256

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2162112566 158 SMAFRHFGNIAAGLIITTLLYGaltglthMVFGANFQIPILAIGLPAVLSVY-FDLFTAFMQAFIISMLTMVFTSMA 233
Cdd:PRK13419  257 ALTVRLFANMTAGHIVILSLIF-------ISFILKSYIVAVAVSVPFAIFIYlLELFVAFLQAYIFTMLSALFIGLA 326
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 26-231 1.04e-18

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 81.48  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  26 NSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNMLGLFGLR-APT 104
Cdd:TIGR01131  18 LSLILLLSLLIFLISSSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIFTLFLFILISNLLGLIPYSfTPT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 105 ADINTTACWAFIEFMLVqIFSIKRKGVIGRIKGLCDP-------PIVTPLNLISEFSTPVSMAFRHFGNIAAGLIITTLL 177
Cdd:TIGR01131  98 SHLSFTLGLALPLWLGL-TISGFRKHPKGFLAHLVPSgtplpliPFLVIIETISYLARPISLSVRLFANISAGHLLLTLL 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2162112566 178 YGALTGLTHMVFGANFQIPILAIGLpavlsvyFDLFTAFMQAFIISMLTMVFTS 231
Cdd:TIGR01131 177 SGLLFSLMSSAIFALLLLILVALII-------LEIFVAFIQAYVFTLLTCLYLN 223
ATP6 MTH00172
ATP synthase F0 subunit 6; Provisional
 26-229 2.58e-05

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214447  Cd Length: 232  Bit Score: 43.88  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  26 NSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNMLGLFG-LRAPT 104
Cdd:MTH00172   19 NSSIMMILVIIVVLLLFKGIKLIPKRWQSIIEIIYNHFHGVVKDNLGNEGLKYFPFIISLFFFIVFLNLLGLFPyVFTPT 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 105 ADINTTACWAFIEFMLVQIFSIKR--KGVIGRIKGLCDPPIVTPL----NLISEFSTPVSMAFRHFGNIAAGLIITTLLY 178
Cdd:MTH00172   99 THIVVTLGLSFSIIIGVTLAGFWRfkWDFFSILMPSGAPLGLAPLlvliETVSYISRAISLGVRLAANLSAGHLLFAILA 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2162112566 179 GaltglthmvFGANFQIPILAIGLPAVLSVYF----DLFTAFMQAFIISMLTMVF 229
Cdd:MTH00172  179 G---------FGFNMLCASGFLSLFPLLIMVFitllEIAVAVIQAYVFCLLTTIY 224
ATP6 MTH00175
ATP synthase F0 subunit 6; Provisional
 8-229 6.19e-03

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177228  Cd Length: 244  Bit Score: 36.91  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566   8 VIFTIPVLGGIPISeTVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFL 87
Cdd:MTH00175   13 RLITIQAFLGDWLV-TFTNSSMMMVLAVIIFWLLLKGDKLIPNRWQSIMELIYLNIRSVVHDNLGKSGQKYFPFILSLFL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  88 FSFFSNMLGLFG-LRAPTADINTTACWAF---IEFMLVQIFSIKRKGVIGRIKG---LCDPPIVTPLNLISEFSTPVSMA 160
Cdd:MTH00175   92 FIAILNILGLFPyVFTPTAHIIITFGLSLsiiIAVTLLGFLTFKWNFLSILMPGgapLVLAPFLVLIETLSYLIRAISLG 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2162112566 161 FRHFGNIAAGliitTLLYGALTGLTHMVFGANFQIPILAIGLPAVLSVYFDLFTAFMQAFIISMLTMVF 229
Cdd:MTH00175  172 VRLAANISAG----HLLFAILSGFAFNMLSNGLIILSLFPMLIMIFITLLEMAVAVIQAYVFCLLTTIY 236
PRK13417 PRK13417
F0F1 ATP synthase subunit A; Provisional
 20-234 6.36e-03

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237380  Cd Length: 352  Bit Score: 37.18  E-value: 6.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  20 ISETVVNSWIVMAILVIGSMLLTRNLQKVPKGAQVLVEKVVETLYSF-----VESTMGKDKVFFAPYIGTLFLFSFFSNM 94
Cdd:PRK13417   94 ITKRVTMMWIVAFFLFLIFIPAANIIAKNPLKVQSRFANTVEVFVNFlrkdiVDESMHGHGHSYYHYIFTLFFFILFCNL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  95 LGLF--------------GLRA----------------------PTADINTTACWAFIEFMLVQIFSIKRKGV------I 132
Cdd:PRK13417  174 MGLVpsvgeltvvasdygGLVAlgvmdhtphalptfakvwsgitVTGDISVTMTLALLTMFLIYGAGFSYQGPkfiwhsV 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 133 GRIKGLCDPPIVTPLNLI-SEFSTPVSMAFRHFGNIAAGLIITTLLYGALtglthMVFGANFQIPILAIGlpAVLSVYFD 211
Cdd:PRK13417  254 PNGVPLLLYPIMWPLEFIvSPMAKTFALTVRLLANMTAGHVIILALMGFI-----FQFQSWGIVPVSVIG--SGLIYVLE 326

                         250       260
                  ....*....|....*....|...
gi 2162112566 212 LFTAFMQAFIISMLTMVFTSMAM 234
Cdd:PRK13417  327 IFVAFLQAYIFVLLTSLFVGLSM 349
ATP6 MTH00176
ATP synthase F0 subunit 6; Provisional
 24-231 6.85e-03

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214449  Cd Length: 229  Bit Score: 36.55  E-value: 6.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566  24 VVNSWIVMAILVIgsmLLTRNLQKVPKGAQVLVEKVVETLYSFVESTMGKDKVFFAPYIGTLFLFSFFSNMLGLF-GLRA 102
Cdd:MTH00176   20 ISLSWITLLLFLL---LMPSSVWFCPSKLQVFMLMFSTFLPEMILRSNGSYILGSASIIISLFILVMSLNLSGLIpYVFT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2162112566 103 PTADINTTACWAFIEFMLVQIFSIKR--KGVIGRIKGLCDPPIVTPL----NLISEFSTPVSMAFRHFGNIAAGLIITTL 176
Cdd:MTH00176   97 STSHLVITLSLALPLWLGVILSGFINnfYSRLSHLVPQGTPPLLNPFlvliELVSLLIRPLTLAVRLAANLSAGHLLLGL 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2162112566 177 LYGALTGLTHMVFganfqIPILAIGLPAVLSVYFDLFTAFMQAFIISMLTMVFTS 231
Cdd:MTH00176  177 LGAAMWGLLPVSP-----LIGFLLLIVQILYFMFEIAVCMIQAYVFTLLLSLYLD 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH