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Conserved domains on  [gi|2173120549|ref|WP_233421931|]
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metalloregulator ArsR/SmtB family transcription factor [Ruegeria profundi]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-85 2.39e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.93  E-value: 2.39e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHWLSEPEshfppqvdgdlvkdgVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPDQV 80
Cdd:COG0640   17 LADPTRLRILRLLAEGE---------------LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81


                 ....*
gi 2173120549 81 ENVLR 85
Cdd:COG0640   82 AELLE 86
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-85 2.39e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.93  E-value: 2.39e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHWLSEPEshfppqvdgdlvkdgVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPDQV 80
Cdd:COG0640   17 LADPTRLRILRLLAEGE---------------LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81


                 ....*
gi 2173120549 81 ENVLR 85
Cdd:COG0640   82 AELLE 86
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-84 1.07e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 70.18  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHWLSEPEshfppqvdgdlvkdgVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPDQV 80
Cdd:NF033788   8 LADPTRLRILELLAEGE---------------LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHV 72


                 ....
gi 2173120549 81 ENVL 84
Cdd:NF033788  73 AELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-87 1.28e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 1.28e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  28 LVKDGVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPDQVENVLRKV 87
Cdd:smart00418  6 LAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-87 5.12e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 60.78  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHwlsepeshfppqvdgDLVKDGVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRP-DQ 79
Cdd:cd00090    4 LSDPTRLRILR---------------LLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaER 68


                 ....*...
gi 2173120549 80 VENVLRKV 87
Cdd:cd00090   69 LLALLESL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 1-64 1.51e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 46.38  E-value: 1.51e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2173120549  1 MAHENRLRIVHWLSEPESHFPPQvdgdlvkdgvcvgfITEKIGLKQPTVTNHMQILQEAGLVES 64
Cdd:pfam12840  7 LADPTRLRILRALVGDEPLTASE--------------LARRLDISRNTLSYHLRKLEEAGLVEV 56
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-77 9.59e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.27  E-value: 9.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2173120549   1 MAHENRLRIVHWLSEpeshfppqvDGDLvkdgvCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRP 77
Cdd:PRK10141   13 LSDETRLGIVLLLRE---------SGEL-----CVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSP 75
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-85 2.39e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.93  E-value: 2.39e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHWLSEPEshfppqvdgdlvkdgVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPDQV 80
Cdd:COG0640   17 LADPTRLRILRLLAEGE---------------LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81


                 ....*
gi 2173120549 81 ENVLR 85
Cdd:COG0640   82 AELLE 86
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-84 1.07e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 70.18  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHWLSEPEshfppqvdgdlvkdgVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPDQV 80
Cdd:NF033788   8 LADPTRLRILELLAEGE---------------LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHV 72


                 ....
gi 2173120549 81 ENVL 84
Cdd:NF033788  73 AELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-87 1.28e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 1.28e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  28 LVKDGVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPDQVENVLRKV 87
Cdd:smart00418  6 LAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-87 5.12e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 60.78  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHwlsepeshfppqvdgDLVKDGVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRP-DQ 79
Cdd:cd00090    4 LSDPTRLRILR---------------LLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaER 68


                 ....*...
gi 2173120549 80 VENVLRKV 87
Cdd:cd00090   69 LLALLESL 76
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
1-86 4.22e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 48.80  E-value: 4.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  1 MAHENRLRIVHWLSEpeshfppqvdgdlvkDGVCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIK----NWVFYKLR 76
Cdd:COG4189   16 LASETRLRILRLLAE---------------EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPgkrgRQKICYLR 80

                         90
                 ....*....|
gi 2173120549 77 PDQVENVLRK 86
Cdd:COG4189   81 VDKILIVLPG 90
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 1-64 1.51e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 46.38  E-value: 1.51e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2173120549  1 MAHENRLRIVHWLSEPESHFPPQvdgdlvkdgvcvgfITEKIGLKQPTVTNHMQILQEAGLVES 64
Cdd:pfam12840  7 LADPTRLRILRALVGDEPLTASE--------------LARRLDISRNTLSYHLRKLEEAGLVEV 56
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
38-78 2.77e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 45.25  E-value: 2.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2173120549  38 ITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRPD 78
Cdd:COG3398   117 LAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-86 4.62e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 43.87  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549   1 MAHENRLRIVHWLSEpESHFPPQvdgdlvkdgvcvgfITEKIGLKQPTVTNHMQILQEAGLVESK-----KIKNWVFYKL 75
Cdd:COG1777    14 LGNPTRRRILALLSE-EPAYVSE--------------LARELGVSRQAVYKHLRKLEEAGLVESYregreDGRARKYYRL 78

                          90
                  ....*....|.
gi 2173120549  76 RPDQVENVLRK 86
Cdd:COG1777    79 SAFRLEVTLTP 89
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-77 9.59e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.27  E-value: 9.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2173120549   1 MAHENRLRIVHWLSEpeshfppqvDGDLvkdgvCVGFITEKIGLKQPTVTNHMQILQEAGLVESKKIKNWVFYKLRP 77
Cdd:PRK10141   13 LSDETRLGIVLLLRE---------SGEL-----CVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSP 75
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 3-62 1.20e-04

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 36.27  E-value: 1.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173120549  3 HENRLRIVHWLSEpeshfppqvdGDLvkdgvCVGFITEKIGLKQPTVTNHMQILQEAGLV 62
Cdd:pfam01022  1 DPTRLKILKLLAE----------GEL-----CVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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