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Conserved domains on  [gi|2173715845|ref|WP_233610633|]
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helix-turn-helix transcriptional regulator [Leuconostoc sp. S51]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10054599)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-60 1.46e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


:

Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 38.30  E-value: 1.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2173715845   5 EKFIKTRKHLRISQVTLCAGI-CTQATLSKFEKHQQIPSFEIMVALCERIGLTLNDV 60
Cdd:cd00093     2 ERLKELRKEKGLTQEELAEKLgVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-60 1.46e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 38.30  E-value: 1.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2173715845   5 EKFIKTRKHLRISQVTLCAGI-CTQATLSKFEKHQQIPSFEIMVALCERIGLTLNDV 60
Cdd:cd00093     2 ERLKELRKEKGLTQEELAEKLgVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-61 2.94e-04

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 38.44  E-value: 2.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2173715845  11 RKHLRISQVTLC--AGIcTQATLSKFEKHQQIPSFEIMVALCERIGLTLNDVF 61
Cdd:COG1396    16 RKARGLTQEELAerLGV-SRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 11-60 5.02e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.05  E-value: 5.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2173715845  11 RKHLRISQVTLCAGIC-TQATLSKFEKHQQIPSFEIMVALCERIGLTLNDV 60
Cdd:pfam01381   5 REELGLSQEELAEKLGvSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-57 6.29e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.03  E-value: 6.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2173715845   11 RKHLRISQVTLCAGI-CTQATLSKFEKHQQIPSFEIMVALCERIGLTL 57
Cdd:smart00530   6 REEKGLTQEELAEKLgVSRSTLSRIENGKRKPSLETLKKLAKALGVSL 53
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-60 1.46e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 38.30  E-value: 1.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2173715845   5 EKFIKTRKHLRISQVTLCAGI-CTQATLSKFEKHQQIPSFEIMVALCERIGLTLNDV 60
Cdd:cd00093     2 ERLKELRKEKGLTQEELAEKLgVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-61 2.94e-04

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 38.44  E-value: 2.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2173715845  11 RKHLRISQVTLC--AGIcTQATLSKFEKHQQIPSFEIMVALCERIGLTLNDVF 61
Cdd:COG1396    16 RKARGLTQEELAerLGV-SRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
11-61 5.96e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 37.13  E-value: 5.96e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2173715845  11 RKHLRISQVTL--CAGIcTQATLSKFEKHQQIPSFEIMVALCERIGLTLNDVF 61
Cdd:COG1476    13 RKERGLTQEELaeLLGV-SRQTISAIENGKYNPSLELALKIARALGVSLEELF 64
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 11-60 5.02e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.05  E-value: 5.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2173715845  11 RKHLRISQVTLCAGIC-TQATLSKFEKHQQIPSFEIMVALCERIGLTLNDV 60
Cdd:pfam01381   5 REELGLSQEELAEKLGvSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-57 6.29e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.03  E-value: 6.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2173715845   11 RKHLRISQVTLCAGI-CTQATLSKFEKHQQIPSFEIMVALCERIGLTL 57
Cdd:smart00530   6 REEKGLTQEELAEKLgVSRSTLSRIENGKRKPSLETLKKLAKALGVSL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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